[ { "uniprot_canonical_ac": "P40526-1", "uniprot_id": [ { "id": "DFG10_YEAST", "url": "https://www.uniprot.org/uniprot/P40526", "type": "external" } ], "mass": 30306.0, "length": 253, "protein_name": "Polyprenal reductase", "gene_name": "DFG10", "organism": "Yeast", "refseq_name": "putative polyprenol reductase", "refseq_ac": [ { "id": "NP_012215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012215", "type": "external" } ], "gene_names_uniprotkb": "DFG10", "gene_names_refseq": "DFG10", "protein_names_uniprotkb": "Polyprenal reductase; 1.3.1.94", "protein_names_refseq": "putative polyprenol reductase", "tax_id": 559292, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); Kahrizi syndrome (Disease Ontology:DOID:0050807); congenital disorder of glycosylation Iq (Disease Ontology:DOID:0080568)", "pathway": " (sce:YIL049W); (R-SCE-193048); (R-SCE-446199)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "20637498;24374639;38821050;9055077;9169870", "class_list": "", "function": "Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol (PubMed:20637498, PubMed:38821050). Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism (PubMed:38821050). Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation (PubMed:20637498, PubMed:38821050)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVN2", "ec_number_list": [ { "id": "1.3.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.94", "type": "external" } ], "go_molecular_function": "GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity;GO:0160198 polyprenal reductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0043048 dolichyl monophosphate biosynthetic process;GO:0007124 pseudohyphal growth", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P40526-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40527-1", "uniprot_id": [ { "id": "ATC7_YEAST", "url": "https://www.uniprot.org/uniprot/P40527", "type": "external" } ], "mass": 130218.0, "length": 1151, "protein_name": "Phospholipid-transporting ATPase NEO1", "gene_name": "NEO1", "organism": "Yeast", "refseq_name": "aminophospholipid-translocating P4-type ATPase NEO1", "refseq_ac": [ { "id": "NP_012216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012216", "type": "external" } ], "gene_names_uniprotkb": "NEO1", "gene_names_refseq": "NEO1", "protein_names_uniprotkb": "Phospholipid-transporting ATPase NEO1; 7.6.2.1", "protein_names_refseq": "aminophospholipid-translocating P4-type ATPase NEO1", "tax_id": 559292, "disease": "neurodevelopmental disorder with poor growth and behavioral abnormalities (Disease Ontology:DOID:0081444)", "pathway": " (sce:YIL048W); (R-SCE-936837)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "12631737;12960419;15314152;16847258;17330950;17563356;18407956;19684113;19779198;21177495;23749301;24374639;27235400;28404745;30824614;31786280;32597660;33481703;33491328;34645814;9169870", "class_list": "", "function": "Flippase that catalyzes the hydrolysis of ATP coupled to the transport of lysophosphatidylserine, phosphatidylethanolamine, and phosphatidylserine from the lumenal to the cytosolic leaflet of the Golgi apparatus membrane and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:27235400, PubMed:30824614, PubMed:34645814). Does not appear to transport phosphatidylcholine or sphingomyelin (PubMed:34645814). May be involved in recycling from endosomes by driving the formation of SNX3-dependent recycling tubules (PubMed:28404745). Required for COPI retrograde transport from the Golgi to the endoplasmic reticulum, Golgi-endosome trafficking, and Golgi-dependent protein glycosylation (PubMed:12960419, PubMed:15314152)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 24, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVN3", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0090555 phosphatidylethanolamine flippase activity;GO:0090556 phosphatidylserine floppase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005770 late endosome", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0045332 phospholipid translocation;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0007033 vacuole organization", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P40527-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40530-1", "uniprot_id": [ { "id": "PDK1_YEAST", "url": "https://www.uniprot.org/uniprot/P40530", "type": "external" } ], "mass": 45444.0, "length": 394, "protein_name": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial", "gene_name": "PKP1", "organism": "Yeast", "refseq_name": "protein kinase PKP1", "refseq_ac": [ { "id": "NP_012222", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012222", "type": "external" } ], "gene_names_uniprotkb": "PKP1", "gene_names_refseq": "PKP1", "protein_names_uniprotkb": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial; 2.7.11.2; PDC kinase 1; PDK 1; Protein kinase of PDH protein 1; Pyruvate dehydrogenase complex kinase 1; Pyruvate dehydrogenase kinase 1; [Pyruvate dehydrogenase [lipoamide]] kinase 1", "protein_names_refseq": "protein kinase PKP1", "tax_id": 559292, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); branched-chain keto acid dehydrogenase kinase deficiency (Disease Ontology:DOID:0090126); Charcot-Marie-Tooth disease X-linked dominant 6 (Disease Ontology:DOID:0110207); oligospermia (Disease Ontology:DOID:14228)", "pathway": " (sce:YIL042C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;15161972;16643908;16823961;17322287;18180296;24374639;9169870", "class_list": "", "function": "Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit (PDA1), thus contributing to the regulation of glucose metabolism. Also involved in telomere maintenance., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVP0", "ec_number_list": [ { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" } ], "go_molecular_function": "GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0010906 regulation of glucose metabolic process;GO:0010510 regulation of pyruvate decarboxylation to acetyl-CoA;GO:0065003 protein-containing complex assembly;GO:1901524 regulation of mitophagy", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P40530-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40535-1", "uniprot_id": [ { "id": "ACA2_YEAST", "url": "https://www.uniprot.org/uniprot/P40535", "type": "external" } ], "mass": 65264.0, "length": 587, "protein_name": "ATF/CREB activator 2", "gene_name": "CST6", "organism": "Yeast", "refseq_name": "Cst6p", "refseq_ac": [ { "id": "NP_012228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012228", "type": "external" } ], "gene_names_uniprotkb": "CST6; ACA2", "gene_names_refseq": "ACA2; CST6; SHF1", "protein_names_uniprotkb": "ATF/CREB activator 2; Chromosome stability protein CST6", "protein_names_refseq": "Cst6p", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL036W); (R-SCE-3214847); (R-SCE-450341)", "pathway_count": 3, "publication_count": 24, "publication_id_list": "10454593;10825197;14562106;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21177495;22218487;23749301;24374639;24909858;30516470;32597660;33229814;33481703;33491328;33502312;9169870", "class_list": "", "function": "Transcriptional activator of promoters containing ATF/CREB sites. Can independently stimulate transcription through ATF/CREB sites. Important for a variety of biological functions including growth on non-optimal carbon sources., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 20, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 20, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 20, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "D6VVP6", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0071400 cellular response to oleic acid;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0033554 cellular response to stress", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "P40535-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40540-1", "uniprot_id": [ { "id": "EMC5_YEAST", "url": "https://www.uniprot.org/uniprot/P40540", "type": "external" } ], "mass": 15907.0, "length": 141, "protein_name": "ER membrane protein complex subunit 5", "gene_name": "EMC5", "organism": "Yeast", "refseq_name": "Emc5p", "refseq_ac": [ { "id": "NP_012237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012237", "type": "external" } ], "gene_names_uniprotkb": "EMC5; KRE27", "gene_names_refseq": "EMC5; KRE27", "protein_names_uniprotkb": "ER membrane protein complex subunit 5; Killer toxin-resistance protein 27", "protein_names_refseq": "Emc5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL027C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;16847258;17322287;19325107;24374639;29809151;9169870", "class_list": "", "function": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29809151). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29809151). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVQ3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0072546 EMC complex;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0015914 phospholipid transport;GO:0006644 phospholipid metabolic process;GO:0034975 protein folding in endoplasmic reticulum;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P40540-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40541-1", "uniprot_id": [ { "id": "SCC3_YEAST", "url": "https://www.uniprot.org/uniprot/P40541", "type": "external" } ], "mass": 133009.0, "length": 1150, "protein_name": "Cohesin subunit SCC3", "gene_name": "IRR1", "organism": "Yeast", "refseq_name": "cohesin subunit IRR1", "refseq_ac": [ { "id": "NP_012238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012238", "type": "external" } ], "gene_names_uniprotkb": "IRR1; SCC3", "gene_names_refseq": "IRR1; SCC3", "protein_names_uniprotkb": "Cohesin subunit SCC3; Irregular cell behavior protein 1", "protein_names_refseq": "cohesin subunit IRR1", "tax_id": 559292, "disease": "Holoprosencephaly 13, X-linked (Disease Ontology:DOID:0060954); autosomal dominant intellectual developmental disorder 47 (Disease Ontology:DOID:0080238); primary ovarian insufficiency 8 (Disease Ontology:DOID:0080865); Mullegama-Klein-Martinez syndrome (Disease Ontology:DOID:0111845); spermatogenic failure 61 (Disease Ontology:DOID:0112350)", "pathway": " (sce:YIL026C); (R-SCE-2468052); (R-SCE-2500257); (R-SCE-3108214)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "11864574;11983169;12402242;14562106;17563356;18407956;19779198;20190278;21126336;23749301;24374639;30516470;32597660;33481703;33491328;7483852;9169870;9990856", "class_list": "", "function": "Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the MCD1/SCC1 subunit of the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVQ4;Q02511", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0030892 mitotic cohesin complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0006473 protein acetylation;GO:0034087 establishment of mitotic sister chromatid cohesion;GO:0007064 mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P40541-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40547-1", "uniprot_id": [ { "id": "VID28_YEAST", "url": "https://www.uniprot.org/uniprot/P40547", "type": "external" } ], "mass": 105491.0, "length": 921, "protein_name": "GID complex subunit 5", "gene_name": "VID28", "organism": "Yeast", "refseq_name": "glucose-induced degradation complex subunit VID28", "refseq_ac": [ { "id": "NP_012247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012247", "type": "external" } ], "gene_names_uniprotkb": "VID28; GID5", "gene_names_refseq": "GID5; VID28; YIL017W", "protein_names_uniprotkb": "GID complex subunit 5; Glucose-induced degradation protein 5; Vacuolar import and degradation protein 28", "protein_names_refseq": "glucose-induced degradation complex subunit VID28", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL017C); (R-SCE-6798695)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "12096123;12686616;14562095;16872538;18407956;18508925;19779198;22645139;23749301;24374639;31708416;32597660;33229814;33491328;33905682;35650207;9169870", "class_list": "", "function": "Component of the GID E3 ligase complex recruiting N termini and catalyzing ubiquitination of proteins targeted for degradation. GID E3 is regulated through assembly with interchangeable N-degron-binding substrate receptors induced by distinct environmental perturbations (PubMed:12686616, PubMed:31708416). Required for the adaptation to the presence of glucose in the growth medium; mediates in association with the substrate receptor VID24/GID4 the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616, PubMed:31708416). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1), malate dehydrogenase (MDH2), and other gluconeogenic enzymes (PubMed:12686616, PubMed:22645139)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VVR2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005773 vacuole;GO:0034657 GID complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045721 negative regulation of gluconeogenesis;GO:0007039 protein catabolic process in the vacuole;GO:0030437 ascospore formation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P40547-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40548-1", "uniprot_id": [ { "id": "SNL1_YEAST", "url": "https://www.uniprot.org/uniprot/P40548", "type": "external" } ], "mass": 18306.0, "length": 159, "protein_name": "HSP70 co-chaperone SNL1", "gene_name": "SNL1", "organism": "Yeast", "refseq_name": "Snl1p", "refseq_ac": [ { "id": "NP_012248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012248", "type": "external" } ], "gene_names_uniprotkb": "SNL1", "gene_names_refseq": "SNL1", "protein_names_uniprotkb": "HSP70 co-chaperone SNL1; Suppressor of NUP116-C lethal", "protein_names_refseq": "Snl1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL016W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12105220;14562106;17322287;24374639;33491328;9169870;9450961", "class_list": "", "function": "Stimulator of ATPase activity of molecular chaperones of the HSP70 family (principally of the SSA class). Stimulation is important for HSP70-substrate complex dissociation after folding of newly synthesized or refolded proteins. SNL1 is probably involved in nuclear pore biogenesis and in particular the folding or refolding of misfolded NUP116, GLE2 and NIC96., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVR3", "ec_number_list": [], "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005739 mitochondrion;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P40548-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40553-1", "uniprot_id": [ { "id": "DOT5_YEAST", "url": "https://www.uniprot.org/uniprot/P40553", "type": "external" } ], "mass": 24120.0, "length": 215, "protein_name": "Peroxiredoxin DOT5", "gene_name": "DOT5", "organism": "Yeast", "refseq_name": "thioredoxin peroxidase DOT5", "refseq_ac": [ { "id": "NP_012255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012255", "type": "external" } ], "gene_names_uniprotkb": "DOT5", "gene_names_refseq": "DOT5", "protein_names_uniprotkb": "Peroxiredoxin DOT5; 1.11.1.24; Disrupter of telomere silencing protein 5; Nuclear thiol peroxidase; Prx; Thioredoxin peroxidase; Thioredoxin-dependent peroxiredoxin DOT5; nTPx", "protein_names_refseq": "thioredoxin peroxidase DOT5", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL010W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10681558;12730197;12925864;14562095;14562106;16245326;16511121;17322287;18407956;24374639;33481703;33491328;9169870;9755194", "class_list": "", "function": "Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Has a role in telomere silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes. Also has a role in the regulation of telomere length. Acts as an alkyl-hydroperoxide reductase in the nucleus during post-diauxic growth. Preferentially reduces alkyl-hydroperoxides rather than hydrogen peroxide. Acts as an antioxidant necessary for stationary phase survival., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VVR9", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" } ], "go_molecular_function": "GO:0008379 thioredoxin peroxidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0034599 cellular response to oxidative stress;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P40553-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40554-1", "uniprot_id": [ { "id": "URM1_YEAST", "url": "https://www.uniprot.org/uniprot/P40554", "type": "external" } ], "mass": 11028.0, "length": 99, "protein_name": "Ubiquitin-related modifier 1", "gene_name": "URM1", "organism": "Yeast", "refseq_name": "ubiquitin-related modifier URM1", "refseq_ac": [ { "id": "NP_012258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012258", "type": "external" } ], "gene_names_uniprotkb": "URM1", "gene_names_refseq": "URM1", "protein_names_uniprotkb": "Ubiquitin-related modifier 1", "protein_names_refseq": "ubiquitin-related modifier URM1", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL008W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10713047;14551258;14555475;14562095;14562106;16864801;17322287;18260097;18491921;18664566;18755837;19017811;19145231;19151091;21209336;24374639;32004955;36102610;38942013;9169870", "class_list": "", "function": "Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation (By similarity) (PubMed:18664566, PubMed:18755837, PubMed:19017811, PubMed:19145231, PubMed:19151091). Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1 (PubMed:10713047, PubMed:14551258, PubMed:14555475, PubMed:21209336, PubMed:32004955). Conjugation does not depend on the canonical cascade of E2 ubiquitin-conjugating enzymes and/or E3 ligases. The conjugation reaction requires a thiocarboxylated C-terminus of URM1 and a peroxidatic cysteine in the target protein, as the sulfur atom of the URM1 thiocarboxyl group is transferred to redox-active cysteine residues in the target protein (PubMed:36102610). Oxidative stress specifically induces the formation of UBL-protein conjugates (PubMed:21209336). Covalent modification with URM1 promotes the phase separation of a wide range of proteins into condensates like stress granules (PubMed:38942013). Indirectly involved in regulation of budding and haploid invasive growth (PubMed:14551258)., [UniProtKB, PubMed, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVS2", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0031386 protein tag activity;GO:0097163 sulfur carrier activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation;GO:0034227 tRNA thio-modification;GO:0034599 cellular response to oxidative stress;GO:0002098 tRNA wobble uridine modification;GO:0032447 protein urmylation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P40554-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40556-1", "uniprot_id": [ { "id": "YIA6_YEAST", "url": "https://www.uniprot.org/uniprot/P40556", "type": "external" } ], "mass": 41954.0, "length": 373, "protein_name": "Mitochondrial nicotinamide adenine dinucleotide transporter 1", "gene_name": "YIA6", "organism": "Yeast", "refseq_name": "NAD+ transporter", "refseq_ac": [ { "id": "NP_012260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012260", "type": "external" } ], "gene_names_uniprotkb": "YIA6; NDT1", "gene_names_refseq": "NDT1; YIA6", "protein_names_uniprotkb": "Mitochondrial nicotinamide adenine dinucleotide transporter 1; Mitochondrial NAD(+) transporter 1", "protein_names_refseq": "NAD+ transporter", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL006W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12887330;16291748;16847258;24374639;32906142;33087354;9169870;9178508", "class_list": "", "function": "Mitochondrial inner membrane carrier protein that mediates the import of NAD(+) into mitochondria (PubMed:16291748, PubMed:32906142, PubMed:33087354). Can transport NAD(+) by unidirectional transport or by exchange with intramitochondrially generated dAMP and dGMP (PubMed:16291748). Also able to transport NAD(+) by exchange with AMP, GMP or deamido-NAD (+) in vitro (PubMed:16291748)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVS4", "ec_number_list": [], "go_molecular_function": "GO:0051724 NAD transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006850 pyruvate import into mitochondria;GO:1990549 mitochondrial NAD transmembrane transport;GO:0035352 NAD transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P40556-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40557-1", "uniprot_id": [ { "id": "EPS1_YEAST", "url": "https://www.uniprot.org/uniprot/P40557", "type": "external" } ], "mass": 81219.0, "length": 701, "protein_name": "ER-retained PMA1-suppressing protein 1", "gene_name": "EPS1", "organism": "Yeast", "refseq_name": "protein disulfide isomerase EPS1", "refseq_ac": [ { "id": "NP_012261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012261", "type": "external" } ], "gene_names_uniprotkb": "EPS1; YIA5W", "gene_names_refseq": "EPS1", "protein_names_uniprotkb": "ER-retained PMA1-suppressing protein 1; 5.3.4.1", "protein_names_refseq": "protein disulfide isomerase EPS1", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL005W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10545109;12881414;14562106;15848158;16002399;17322287;24374639;32597660;33481703;7762303;9169870", "class_list": "", "function": "Acts as a membrane-bound chaperone in endoplasmic reticulum quality control. Probably facilitates presentation of substrate to membrane-bound components of the degradation machinery., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VVS5", "ec_number_list": [], "go_molecular_function": "GO:0019153 protein-disulfide reductase (glutathione) activity;GO:0051082 unfolded protein binding;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006457 protein folding;GO:0036503 ERAD pathway;GO:0006621 protein retention in ER lumen", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P40557-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40558-1", "uniprot_id": [ { "id": "CFD1_YEAST", "url": "https://www.uniprot.org/uniprot/P40558", "type": "external" } ], "mass": 31922.0, "length": 293, "protein_name": "Cytosolic Fe-S cluster assembly factor CFD1", "gene_name": "CFD1", "organism": "Yeast", "refseq_name": "iron-sulfur cluster assembly protein CFD1", "refseq_ac": [ { "id": "NP_012263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012263", "type": "external" } ], "gene_names_uniprotkb": "CFD1; DRE3; RIX19; YIA3W", "gene_names_refseq": "CFD1; DRE3", "protein_names_uniprotkb": "Cytosolic Fe-S cluster assembly factor CFD1; Cytosolic Fe-S cluster-deficient protein 1; Ribosomal export protein 19", "protein_names_refseq": "iron-sulfur cluster assembly protein CFD1", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL003W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "12970194;15660135;17322287;17330950;17401378;17563356;19779198;19795423;19823750;20702584;21177495;22362766;23749301;24374639;31040179;32597660;33481703;33491328;7762303;9169870", "class_list": "", "function": "Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery (PubMed:12970194, PubMed:15660135, PubMed:17401378). Required for maturation of extramitochondrial Fe-S proteins (PubMed:12970194, PubMed:15660135, PubMed:17401378, PubMed:22362766, PubMed:31040179). The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (PubMed:17401378, PubMed:22362766). Nucleotide binding/hydrolysis seems to be critcal for loading of Fe-S clusters onto CFD1 and NBP35 (PubMed:22362766). Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export (PubMed:15660135)., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVS7", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051536 iron-sulfur cluster binding;GO:0140663 ATP-dependent FeS chaperone activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1904564 cytosolic [4Fe-4S] assembly scaffold complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0002098 tRNA wobble uridine modification", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P40558-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40562-1", "uniprot_id": [ { "id": "MPH1_YEAST", "url": "https://www.uniprot.org/uniprot/P40562", "type": "external" } ], "mass": 114058.0, "length": 993, "protein_name": "ATP-dependent DNA helicase MPH1", "gene_name": "MPH1", "organism": "Yeast", "refseq_name": "3'-5' DNA helicase", "refseq_ac": [ { "id": "NP_012267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012267", "type": "external" } ], "gene_names_uniprotkb": "MPH1; YIB2C", "gene_names_refseq": "MPH1", "protein_names_uniprotkb": "ATP-dependent DNA helicase MPH1; 5.6.2.4; DNA 3'-5' helicase MPH1; FANCM-like protein 1; Mutator phenotype protein 1", "protein_names_refseq": "3'-5' DNA helicase", "tax_id": 559292, "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); immunodeficiency 95 (Disease Ontology:DOID:0061065); primary ovarian insufficiency 15 (Disease Ontology:DOID:0080872); spermatogenic failure 28 (Disease Ontology:DOID:0111916); Fanconi anemia (Disease Ontology:DOID:13636); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (sce:YIR002C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10628851;10880470;14562095;15126389;15634678;16121259;18407956;19136626;19181670;20347428;22912599;24119400;24374639;27017623;27257873;32597660;33491328;7762303;9169870", "class_list": "", "function": "ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance (PubMed:10880470, PubMed:15126389, PubMed:15634678, PubMed:16121259). Capable of unwinding D-loops (PubMed:19136626). Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair (PubMed:19136626). Prevents crossovers between ectopic sequences by removing substrates for MUS81-MMS4 or RAD1-RAD10 cleavage (PubMed:24119400). Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (Probable) (PubMed:22912599). Binds to flap-structured DNA but not to non-flap nicked DNA, and participates in Okazaki fragment processing by stimulating the endonuclease activities of FEN1 and DNA2 (PubMed:19181670). Involved in recombination donor preference during mating-type switching via interaction with FKH1 (PubMed:27257873)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VVT2", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0033677 DNA/RNA helicase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0000400 four-way junction DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0036297 interstrand cross-link repair;GO:0000725 recombinational repair;GO:0033567 DNA replication, Okazaki fragment processing;GO:0045003 double-strand break repair via synthesis-dependent strand annealing;GO:0060543 negative regulation of strand invasion", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P40562-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40564-1", "uniprot_id": [ { "id": "DJP1_YEAST", "url": "https://www.uniprot.org/uniprot/P40564", "type": "external" } ], "mass": 48575.0, "length": 432, "protein_name": "DnaJ-like protein 1", "gene_name": "DJP1", "organism": "Yeast", "refseq_name": "Djp1p", "refseq_ac": [ { "id": "NP_012269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012269", "type": "external" } ], "gene_names_uniprotkb": "DJP1; ICS1; PAS22; YIB4W", "gene_names_refseq": "DJP1; ICS1; PAS22", "protein_names_uniprotkb": "DnaJ-like protein 1; Peroxisome assembly protein 22", "protein_names_refseq": "Djp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YIR004W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562106;15590828;17322287;20702584;21126336;23749301;24374639;32597660;33481703;33491328;7507454;7762303;9169870;9679141", "class_list": "", "function": "Required for peroxisomal protein import which maintains the function of peroxisomes., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVT4;Q6Q5N6", "ec_number_list": [], "go_molecular_function": "GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0071944 cell periphery;GO:0005933 cellular bud", "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0006626 protein targeting to mitochondrion;GO:0016558 protein import into peroxisome matrix", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P40564-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40565-1", "uniprot_id": [ { "id": "IST3_YEAST", "url": "https://www.uniprot.org/uniprot/P40565", "type": "external" } ], "mass": 17098.0, "length": 148, "protein_name": "U2 snRNP component IST3", "gene_name": "IST3", "organism": "Yeast", "refseq_name": "U2 snRNP complex subunit IST3", "refseq_ac": [ { "id": "NP_012270", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012270", "type": "external" } ], "gene_names_uniprotkb": "IST3; SNU17; YIB5W", "gene_names_refseq": "IST3; SNU17", "protein_names_uniprotkb": "U2 snRNP component IST3; Increased sodium tolerance protein 3; U2 snRNP protein SNU17", "protein_names_refseq": "U2 snRNP complex subunit IST3", "tax_id": 559292, "disease": "", "pathway": " (sce:YIR005W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "11287609;11804584;11884590;14517302;14562095;14562106;14973223;15565172;16618970;17322287;23118884;24374639;25160624;25218446;26212312;27445306;27562955;29794219;33491328;7762303;9169870", "class_list": "", "function": "Required for pre-mRNA splicing and spliceosome assembly. As part of the pre-mRNA retention and splicing (RES) complex, required for efficient splicing and nuclear retention of not properly spliced pre-mRNA (PubMed:11287609, PubMed:15565172). Required for MER1-activated splicing (PubMed:14973223)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVT5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005686 U2 snRNP;GO:0071011 precatalytic spliceosome;GO:0070274 RES complex", "go_biological_process": "GO:0000349 generation of catalytic spliceosome for first transesterification step;GO:0006406 mRNA export from nucleus;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:1903241 U2-type prespliceosome assembly", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P40565-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40571-1", "uniprot_id": [ { "id": "RPR2_YEAST", "url": "https://www.uniprot.org/uniprot/P40571", "type": "external" } ], "mass": 16344.0, "length": 144, "protein_name": "Ribonuclease P protein subunit RPR2", "gene_name": "RPR2", "organism": "Yeast", "refseq_name": "ribonuclease P protein subunit RPR2", "refseq_ac": [ { "id": "NP_012280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012280", "type": "external" } ], "gene_names_uniprotkb": "RPR2", "gene_names_refseq": "RPR2", "protein_names_uniprotkb": "Ribonuclease P protein subunit RPR2; 3.1.26.5; RNA-processing protein RPR2; RNase P 16.4 kDa subunit", "protein_names_refseq": "ribonuclease P protein subunit RPR2", "tax_id": 559292, "disease": "", "pathway": " (sce:YIR015W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14562095;14562106;17322287;24374639;9169870;9620854", "class_list": "", "function": "Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVU5", "ec_number_list": [ { "id": "2.1.1.309", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.309", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.26.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.5", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004526 ribonuclease P activity", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0001682 tRNA 5'-leader removal;GO:0034965 intronic box C/D snoRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P40571-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40581-1", "uniprot_id": [ { "id": "GPX3_YEAST", "url": "https://www.uniprot.org/uniprot/P40581", "type": "external" } ], "mass": 18641.0, "length": 163, "protein_name": "Glutathione peroxidase-like peroxiredoxin HYR1", "gene_name": "HYR1", "organism": "Yeast", "refseq_name": "peroxiredoxin HYR1", "refseq_ac": [ { "id": "NP_012303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012303", "type": "external" } ], "gene_names_uniprotkb": "HYR1; GPX3; ORP1", "gene_names_refseq": "GPX3; HYR1; ORP1", "protein_names_uniprotkb": "Glutathione peroxidase-like peroxiredoxin HYR1; 1.11.1.24; GPx 3; Glutathione peroxidase homolog 3; Hydrogen peroxide resistance protein 1; Oxidant receptor peroxidase 1; PHGPx3; Phospholipid hydroperoxide glutathione peroxidase 3", "protein_names_refseq": "peroxiredoxin HYR1", "tax_id": 559292, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); spondylometaphyseal dysplasia Sedaghatian type (Disease Ontology:DOID:0112298); pre-eclampsia (Disease Ontology:DOID:10591); nephrotic syndrome (Disease Ontology:DOID:1184); colon cancer (Disease Ontology:DOID:219); acute kidney failure (Disease Ontology:DOID:3021); gastric adenocarcinoma (Disease Ontology:DOID:3717); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YIR037W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10480913;11445588;12437921;12743123;14556853;14562095;14562106;15337745;17720812;18767166;19230722;19779198;22659048;22984289;24374639;33481703;33491328;9169870;9315326", "class_list": "", "function": "Involved in oxidative stress response and redox homeostasis. Functions as a sensor and transducer of hydroperoxide stress. In response to hydroperoxide stress it oxidizes (activates) the transcription activator YAP1, which is involved in transcription activation of genes of the oxidative stress response pathway. May also play a direct role in hydroperoxide scavenging, being the most active of three closely related S.cerevisiae peroxiredoxins (GPX1, GPX2, and HYR1/GPX3) with respect to peroxide and lipid hydroperoxide reduction. The three enzymes are not required for the glutaredoxin-mediated antioxidant function. In the presence of peroxides, HYR1/GPX3 is directly oxidized at Cys-36 to form a cysteine sulfenic acid (-SOH). Cys-36-SOH then forms either an intramolecular disulfide bond (Cys-36 with Cys-82) or a transient, intermolecular disulfide bond with 'Cys-598' of YAP1, which is further resolved into a YAP1 intramolecular disulfide bond ('Cys-303' with 'Cys-598'), which causes its nuclear accumulation and activation, and a reduced Cys-36 in HYR1/GPX3., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVW8", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" } ], "go_molecular_function": "GO:0004602 glutathione peroxidase activity;GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity;GO:0140824 thioredoxin-dependent peroxiredoxin activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005782 peroxisomal matrix;GO:0005829 cytosol", "go_biological_process": "GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P40581-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40825-1", "uniprot_id": [ { "id": "SYA_YEAST", "url": "https://www.uniprot.org/uniprot/P40825", "type": "external" } ], "mass": 110059.0, "length": 983, "protein_name": "Alanine--tRNA ligase, mitochondrial", "gene_name": "ALA1", "organism": "Yeast", "refseq_name": "alanine--tRNA ligase", "refseq_ac": [ { "id": "NP_014980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014980", "type": "external" } ], "gene_names_uniprotkb": "ALA1; CDC64", "gene_names_refseq": "ALA1; CDC64", "protein_names_uniprotkb": "Alanine--tRNA ligase, mitochondrial; 6.1.1.7; AlaRS; Alanyl-tRNA synthetase", "protein_names_refseq": "alanine--tRNA ligase", "tax_id": 559292, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); nonphotosensitive trichothiodystrophy 8 (Disease Ontology:DOID:0061023); progressive leukoencephalopathy with ovarian failure (Disease Ontology:DOID:0070396); developmental and epileptic encephalopathy 29 (Disease Ontology:DOID:0080451); Charcot-Marie-Tooth disease axonal type 2N (Disease Ontology:DOID:0110177); combined oxidative phosphorylation deficiency 8 (Disease Ontology:DOID:0111479); dermatomyositis (Disease Ontology:DOID:10223); leukodystrophy (Disease Ontology:DOID:10579); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); microcephaly (Disease Ontology:DOID:10907); axonal neuropathy (Disease Ontology:DOID:7319)", "pathway": " (sce:YOR335C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562095;14562106;14576278;15358761;16556230;18407956;19779198;24374639;32597660;33481703;33491328;7761427;8896263;9169874", "class_list": "", "function": "Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W330", "ec_number_list": [ { "id": "6.1.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.7", "type": "external" } ], "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:1990825 sequence-specific mRNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0070143 mitochondrial alanyl-tRNA aminoacylation;GO:0006419 alanyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P40825-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40850-1", "uniprot_id": [ { "id": "MKT1_YEAST", "url": "https://www.uniprot.org/uniprot/P40850", "type": "external" } ], "mass": 94495.0, "length": 830, "protein_name": "Post-transcriptional regulator MKT1", "gene_name": "MKT1", "organism": "Yeast", "refseq_name": "Mkt1p", "refseq_ac": [ { "id": "NP_014314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014314", "type": "external" } ], "gene_names_uniprotkb": "MKT1; N2302", "gene_names_refseq": "MKT1", "protein_names_uniprotkb": "Post-transcriptional regulator MKT1; Inactive endonuclease MKT1", "protein_names_refseq": "Mkt1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL085W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "11907579;14562106;15082763;15665377;16273108;17330950;18407956;19779198;20702584;21126336;22106047;22814378;23749301;24374639;30516470;32597660;33229814;33481703;33491328;7532890;8740422;9169873", "class_list": "", "function": "Involved in 3'-UTR mediated RNA regulation (PubMed:15082763). Binds to RNA-binding and RNA regulatory proteins (PubMed:15082763). Complexes with PAB1-binding protein to promote mRNA interactions with poly(A)-binding protein (PubMed:15082763). Promotes mating-type switching in mother cells by positively regulating HO expression (PubMed:15082763)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "D6W194;Q45T81;Q8TF89", "ec_number_list": [], "go_molecular_function": "GO:0004520 DNA endonuclease activity;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0005840 ribosome;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006417 regulation of translation;GO:0006974 DNA damage response;GO:0045727 positive regulation of translation;GO:0031494 regulation of mating type switching", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P40850-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40851-1", "uniprot_id": [ { "id": "AXL1_YEAST", "url": "https://www.uniprot.org/uniprot/P40851", "type": "external" } ], "mass": 138332.0, "length": 1208, "protein_name": "A-factor-processing protease AXL1", "gene_name": "AXL1", "organism": "Yeast", "refseq_name": "Axl1p", "refseq_ac": [ { "id": "NP_015447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015447", "type": "external" } ], "gene_names_uniprotkb": "AXL1; FUS5; P9642.4; STE22", "gene_names_refseq": "AXL1; FUS5; STE22", "protein_names_uniprotkb": "A-factor-processing protease AXL1; 3.4.24.-; Axial budding protein 1", "protein_names_refseq": "Axl1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR122W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12176366;14562106;17287358;21126336;24374639;33491328;7569998;7990931;9015298;9169875", "class_list": "", "function": "Involved in the N-terminal endoproteolytic cleavage of the P2 precursor of the a-factor mating pheromone (PubMed:7569998, PubMed:9015298). Involved in axial budding (PubMed:7990931). Contributes to axial budding through a nonproteolytic mechanism (Probable)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4C1", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005935 cellular bud neck;GO:0043332 mating projection tip", "go_biological_process": "GO:0051603 proteolysis involved in protein catabolic process;GO:0000755 cytogamy;GO:0007120 axial cellular bud site selection;GO:0007323 peptide pheromone maturation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P40851-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40892-1", "uniprot_id": [ { "id": "YJV8_YEAST", "url": "https://www.uniprot.org/uniprot/P40892", "type": "external" } ], "mass": 21480.0, "length": 196, "protein_name": "Putative acetyltransferase YJL218W", "gene_name": "HRA196; J0224", "organism": "Yeast", "refseq_name": "acetyltransferase", "refseq_ac": [ { "id": "NP_012317", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012317", "type": "external" } ], "gene_names_uniprotkb": "HRA196; J0224", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative acetyltransferase YJL218W; 2.3.1.-", "protein_names_refseq": "acetyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL218W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17322287;24374639;33491328;7725802;8641269", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVX8", "ec_number_list": [], "go_molecular_function": "GO:0008870 galactoside O-acetyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P40892-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40917-1", "uniprot_id": [ { "id": "YAP4_YEAST", "url": "https://www.uniprot.org/uniprot/P40917", "type": "external" } ], "mass": 32975.0, "length": 295, "protein_name": "AP-1-like transcription factor YAP4", "gene_name": "CIN5", "organism": "Yeast", "refseq_name": "Cin5p", "refseq_ac": [ { "id": "NP_014671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014671", "type": "external" } ], "gene_names_uniprotkb": "CIN5; HAL6; OR26.18; SDS15; YAP4", "gene_names_refseq": "CIN5; HAL6; YAP4", "protein_names_uniprotkb": "AP-1-like transcription factor YAP4; Chromosome instability protein 5; Transcription activator CIN5", "protein_names_refseq": "Cin5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR028C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11179441;12399584;14555958;14562095;18407956;19774548;19779198;20702584;21177495;23749301;24374639;32597660;33481703;33491328;9169874;9372930;9559673;9593122", "class_list": "", "function": "Transcription activator involved in the regulation of genes expressed in response to environmental changes and metabolic requirements. According to genome-wide promoter binding and gene expression studies it regulates, among others, genes involved in ribosome biogenesis, and protein synthesis. It may also be involved in pleiotropic drug resistance. When overexpressed it confers increased resistance to cisplatin, the DNA-alkylating agents methylmethanosulfonate, and mitomycin C, the antimalarial drugs quinidine, mefloquine, and chloroquine, and increases cellular tolerance to sodium and lithium. Preferentially binds 5'-TTACTAA-3'., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W294", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0043565 sequence-specific DNA binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009410 response to xenobiotic stimulus;GO:0042538 hyperosmotic salinity response;GO:0006972 hyperosmotic response", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P40917-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40959-1", "uniprot_id": [ { "id": "MVP1_YEAST", "url": "https://www.uniprot.org/uniprot/P40959", "type": "external" } ], "mass": 59657.0, "length": 511, "protein_name": "Sorting nexin MVP1", "gene_name": "MVP1", "organism": "Yeast", "refseq_name": "Mvp1p", "refseq_ac": [ { "id": "NP_013717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013717", "type": "external" } ], "gene_names_uniprotkb": "MVP1; YM8270.06", "gene_names_refseq": "MVP1", "protein_names_uniprotkb": "Sorting nexin MVP1", "protein_names_refseq": "Mvp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR004W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11557775;14562106;17563356;18407956;19779198;23749301;24374639;24567361;27883263;32198400;32597660;33491328;7862158;9169872", "class_list": "", "function": "Required for vacuolar protein sorting (PubMed:7862158). Component of the retromer-mediated endosome-to-Golgi retrograde pathway (PubMed:24567361, PubMed:27883263). Required for efficient cargo export from the endosome, promoting VPS1-mediated fission of retromer-coated tubules that bud from the endosome (PubMed:24567361)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZH9", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0010008 endosome membrane", "go_biological_process": "GO:0042147 retrograde transport, endosome to Golgi;GO:0097320 plasma membrane tubulation;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P40959-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40961-1", "uniprot_id": [ { "id": "PHB1_YEAST", "url": "https://www.uniprot.org/uniprot/P40961", "type": "external" } ], "mass": 31427.0, "length": 287, "protein_name": "Prohibitin-1", "gene_name": "PHB1", "organism": "Yeast", "refseq_name": "prohibitin subunit PHB1", "refseq_ac": [ { "id": "NP_011648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011648", "type": "external" } ], "gene_names_uniprotkb": "PHB1; PHB", "gene_names_refseq": "PHB1", "protein_names_uniprotkb": "Prohibitin-1", "protein_names_refseq": "prohibitin subunit PHB1", "tax_id": 559292, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); transitional cell carcinoma (Disease Ontology:DOID:2671); sporadic breast cancer (Disease Ontology:DOID:8029); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (sce:YGR132C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10207067;10835343;12237468;14562095;14562106;14576278;15525670;17322287;24374639;31522117;32597660;33491328;38964378;9169869", "class_list": "", "function": "Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins (PubMed:10835343). Involved in mitophagy; may act as an adapter for ATG8 that supports mitophagosome assembly (PubMed:38964378). Negatively regulates the proteolytic processing of ATG32 via the i-AAA protease (PubMed:38964378). Acts as a negative regulator of the m-AAA protease (PubMed:10207067)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUR4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0007005 mitochondrion organization;GO:0045861 negative regulation of proteolysis;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P40961-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40988-1", "uniprot_id": [ { "id": "FET4_YEAST", "url": "https://www.uniprot.org/uniprot/P40988", "type": "external" } ], "mass": 62792.0, "length": 552, "protein_name": "Low-affinity Fe(2+) transport protein", "gene_name": "FET4", "organism": "Yeast", "refseq_name": "Fet4p", "refseq_ac": [ { "id": "NP_014052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014052", "type": "external" } ], "gene_names_uniprotkb": "FET4; YM9924.11C", "gene_names_refseq": "FET4", "protein_names_uniprotkb": "Low-affinity Fe(2+) transport protein; Low-affinity Fe(II) transport protein", "protein_names_refseq": "Fet4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR319C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562106;16847258;19779198;22106047;23749301;24374639;32597660;33481703;7929320;9169872", "class_list": "", "function": "Required for Fe(2+) ion low affinity uptake., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0E7", "ec_number_list": [], "go_molecular_function": "GO:0005375 copper ion transmembrane transporter activity;GO:0005381 iron ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006829 zinc ion transport;GO:0034755 iron ion transmembrane transport;GO:0006825 copper ion transport;GO:0015677 copper ion import", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P40988-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40989-1", "uniprot_id": [ { "id": "FKS2_YEAST", "url": "https://www.uniprot.org/uniprot/P40989", "type": "external" } ], "mass": 216990.0, "length": 1895, "protein_name": "1,3-beta-glucan synthase component GSC2", "gene_name": "GSC2", "organism": "Yeast", "refseq_name": "1,3-beta-glucan synthase GSC2", "refseq_ac": [ { "id": "NP_011546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011546", "type": "external" } ], "gene_names_uniprotkb": "GSC2; FKS2; GLS2", "gene_names_refseq": "FKS2; GSC2", "protein_names_uniprotkb": "1,3-beta-glucan synthase component GSC2; 1,3-beta-D-glucan-UDP glucosyltransferase; 2.4.1.34; FK506 sensitivity protein 2; Glucan synthase of cerevisiae protein 2", "protein_names_refseq": "1,3-beta-glucan synthase GSC2", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR032W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "15166135;16116083;16273108;16847258;17158736;18407956;19779198;24374639;33491328;7565718;7649185;8662910;9169869;9290212", "class_list": "glycogene;glycosyltransferase", "function": "Alternate catalytic subunit of the 1,3-beta-glucan synthase (GS) complex. Synthesizes 1,3-beta-glucan, a major structural component of the yeast cell wall. Required for spore wall assembly. Negative regulation of activity by SMK1 is important for spore wall deposition. Activity is positively regulated by RHO1., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUG8;Q45U52", "ec_number_list": [ { "id": "2.4.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.34", "type": "external" } ], "go_molecular_function": "GO:0003843 1,3-beta-D-glucan synthase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0071944 cell periphery;GO:0000148 1,3-beta-D-glucan synthase complex;GO:0005628 prospore membrane", "go_biological_process": "GO:0006075 (1->3)-beta-D-glucan biosynthetic process;GO:0030476 ascospore wall assembly;GO:0051278 fungal-type cell wall polysaccharide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P40989-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40991-1", "uniprot_id": [ { "id": "NOP2_YEAST", "url": "https://www.uniprot.org/uniprot/P40991", "type": "external" } ], "mass": 69812.0, "length": 618, "protein_name": "25S rRNA (cytosine(2870)-C(5))-methyltransferase", "gene_name": "NOP2", "organism": "Yeast", "refseq_name": "rRNA (cytosine-C5-)-methyltransferase NOP2", "refseq_ac": [ { "id": "NP_014338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014338", "type": "external" } ], "gene_names_uniprotkb": "NOP2; N2428; YNA1; YNL2428W", "gene_names_refseq": "NOP2; YNA1", "protein_names_uniprotkb": "25S rRNA (cytosine(2870)-C(5))-methyltransferase; 2.1.1.310; Nucleolar protein 2", "protein_names_refseq": "rRNA (cytosine-C5-)-methyltransferase NOP2", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162); Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (sce:YNL061W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562106;15686447;17322287;17330950;19779198;21126336;22956767;23749301;23913415;24374639;32597660;33481703;33491328;7806561;8533472;9169873;9854021", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA. Required for 60S ribosomal subunit synthesis and processing., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W1B9;E9P914", "ec_number_list": [ { "id": "2.1.1.310", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.310", "type": "external" } ], "go_molecular_function": "GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0031167 rRNA methylation;GO:0042273 ribosomal large subunit biogenesis;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0070475 rRNA base methylation;GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P40991-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40992-1", "uniprot_id": [ { "id": "RRN7_YEAST", "url": "https://www.uniprot.org/uniprot/P40992", "type": "external" } ], "mass": 60357.0, "length": 514, "protein_name": "RNA polymerase I-specific transcription initiation factor RRN7", "gene_name": "RRN7", "organism": "Yeast", "refseq_name": "Rrn7p", "refseq_ac": [ { "id": "NP_012509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012509", "type": "external" } ], "gene_names_uniprotkb": "RRN7; J1273", "gene_names_refseq": "RRN7", "protein_names_uniprotkb": "RNA polymerase I-specific transcription initiation factor RRN7", "protein_names_refseq": "Rrn7p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL025W); (R-SCE-73772)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14562095;14562106;17322287;21921198;21940764;24374639;7958901;8641269;8702872;8887672;8895657", "class_list": "", "function": "Component of RNA polymerase I core factor complex (CF) that acts as a SUA7/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment. After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP-dependent manner to form a pre-initiation complex., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWF7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0017025 TBP-class protein binding;GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0070860 RNA polymerase I core factor complex", "go_biological_process": "GO:0042790 nucleolar large rRNA transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P40992-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40993-1", "uniprot_id": [ { "id": "RMRP_YEAST", "url": "https://www.uniprot.org/uniprot/P40993", "type": "external" } ], "mass": 22541.0, "length": 198, "protein_name": "Ribonuclease MRP protein subunit SNM1", "gene_name": "SNM1", "organism": "Yeast", "refseq_name": "Snm1p", "refseq_ac": [ { "id": "NP_010766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010766", "type": "external" } ], "gene_names_uniprotkb": "SNM1; D8035.21", "gene_names_refseq": "SNM1", "protein_names_uniprotkb": "Ribonuclease MRP protein subunit SNM1; RNA-processing protein SNM1; RNase MRP 22.5 kDa subunit", "protein_names_refseq": "Snm1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR478W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562095;14562106;14690591;15637077;17322287;17563356;18407956;22814378;24374639;30516470;33491328;7958920;9169867", "class_list": "", "function": "Essential component of the MRP ribonucleoprotein endoribonuclease that cleaves mitochondrial primer RNA sequences., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTA1;Q6B1P4", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0004518 nuclease activity;GO:0042134 rRNA primary transcript binding", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0000172 ribonuclease MRP complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008033 tRNA processing;GO:0006364 rRNA processing;GO:0000460 maturation of 5.8S rRNA;GO:0030541 plasmid partitioning", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P40993-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41056-1", "uniprot_id": [ { "id": "RL33B_YEAST", "url": "https://www.uniprot.org/uniprot/P41056", "type": "external" } ], "mass": 12168.0, "length": 107, "protein_name": "Large ribosomal subunit protein eL33B", "gene_name": "RPL33B", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL33 RPL33B", "refseq_ac": [ { "id": "NP_014877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014877", "type": "external" } ], "gene_names_uniprotkb": "RPL33B; O5224; RPL37B", "gene_names_refseq": "RPL33B; RPL37B", "protein_names_uniprotkb": "Large ribosomal subunit protein eL33B; 60S ribosomal protein L33-B; L37; RP47; YL37", "protein_names_refseq": "60S ribosomal protein eL33 RPL33B", "tax_id": 559292, "disease": "Diamond-Blackfan anemia 5 (Disease Ontology:DOID:0111883); glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (sce:YOR234C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;18782943;22096102;24374639;24524803;33481703;33491328;8082197;8972580;9169874;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2T8", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P41056-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41277-1", "uniprot_id": [ { "id": "GPP1_YEAST", "url": "https://www.uniprot.org/uniprot/P41277", "type": "external" } ], "mass": 27947.0, "length": 250, "protein_name": "Glycerol-1-phosphate phosphohydrolase 1", "gene_name": "GPP1", "organism": "Yeast", "refseq_name": "glycerol-1-phosphatase GPP1", "refseq_ac": [ { "id": "NP_012211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012211", "type": "external" } ], "gene_names_uniprotkb": "GPP1; RHR2", "gene_names_refseq": "GPP1; RHR2", "protein_names_uniprotkb": "Glycerol-1-phosphate phosphohydrolase 1; (DL)-glycerol-3-phosphatase 1; 3.1.3.21; Related to HOR2 protein 2", "protein_names_refseq": "glycerol-1-phosphatase GPP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL053W)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "10931288;11058591;11113971;14562095;14562106;15066826;15113568;15166219;16358322;17287358;17425669;18407956;18438874;19779198;20702584;20803479;21126336;22106047;24374639;30516470;32597660;33481703;33491328;7500933;7895733;8662716;9038161;9150920;9169870", "class_list": "", "function": "Major isoform of glycerol-1-phosphate phosphohydrolase involved in glycerol biosynthesis. Plays a role in osmoadaptation and required for adaptation to anaerobic conditions., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVM8;P38012", "ec_number_list": [ { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.50", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.50", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000121 sn-glycerol 1-phosphatase activity;GO:0043136 sn-glycerol 3-phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006970 response to osmotic stress;GO:0006114 glycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P41277-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41338-1", "uniprot_id": [ { "id": "ERG10_YEAST", "url": "https://www.uniprot.org/uniprot/P41338", "type": "external" } ], "mass": 41729.0, "length": 398, "protein_name": "Acetyl-CoA acetyltransferase", "gene_name": "ERG10", "organism": "Yeast", "refseq_name": "acetyl-CoA C-acetyltransferase", "refseq_ac": [ { "id": "NP_015297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015297", "type": "external" } ], "gene_names_uniprotkb": "ERG10; LPB3", "gene_names_refseq": "ERG10; LPB3; TSM0115", "protein_names_uniprotkb": "Acetyl-CoA acetyltransferase; 2.3.1.9; Acetoacetyl-CoA thiolase; Ergosterol biosynthesis protein 10", "protein_names_refseq": "acetyl-CoA C-acetyltransferase", "tax_id": 559292, "disease": "nephrotic syndrome (Disease Ontology:DOID:1184); beta-ketothiolase deficiency (Disease Ontology:DOID:14723); arteriosclerosis (Disease Ontology:DOID:2349); carbohydrate metabolic disorder (Disease Ontology:DOID:2978); end stage renal disease (Disease Ontology:DOID:783); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YPL028W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12039763;14562106;18407956;22218487;22814378;24374639;29372902;32679672;33481703;33491328;5571829;5571830;7989303;8754796;9169875", "class_list": "", "function": "Acetyl-CoA acetyltransferase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (PubMed:5571829, PubMed:7989303). ERG10 catalyzes the formation of acetoacetyl-CoA from acetyl-CoA (PubMed:5571829, PubMed:7989303). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10 that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 and HMG2 which are derived from a single ancestral HMGR gene by gene duplication (PubMed:32679672)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3Y5", "ec_number_list": [ { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003985 acetyl-CoA C-acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005773 vacuole", "go_biological_process": "GO:0006696 ergosterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P41338-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41546-2", "uniprot_id": [ { "id": "HAC1_YEAST", "url": "https://www.uniprot.org/uniprot/P41546", "type": "external" } ], "mass": 26905.0, "length": 238, "protein_name": "Transcriptional activator HAC1", "gene_name": "HAC1", "organism": "Yeast", "refseq_name": "transcription factor HAC1", "refseq_ac": [ { "id": "NP_116622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116622", "type": "external" } ], "gene_names_uniprotkb": "HAC1; ERN4; IRE15; IRE2", "gene_names_refseq": "ERN4; HAC1; IRE15", "protein_names_uniprotkb": "Transcriptional activator HAC1", "protein_names_refseq": "transcription factor HAC1", "tax_id": 559292, "disease": "", "pathway": " (sce:YFL031W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11595189;14562095;14562106;17108329;19779198;23749301;24374639;31208443;33481703;33491328;7670463;7816617;8898193;8898194;8932376;9077435;9323131;9348528", "class_list": "", "function": "Transcriptional activator involved in the unfolded protein response (UPR) pathway. Recognizes and binds to the UPR element (UPRE) in the promoter of UPR-regulated genes such as KAR2, PDI1, EUG1 and FKB2. Increases the synthesis of endoplasmic reticulum-resident proteins required for protein folding as well as components of the secretory pathway., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTJ9;P87040", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P41546-2", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41697-1", "uniprot_id": [ { "id": "BUD6_YEAST", "url": "https://www.uniprot.org/uniprot/P41697", "type": "external" } ], "mass": 88817.0, "length": 788, "protein_name": "Bud site selection protein 6", "gene_name": "BUD6", "organism": "Yeast", "refseq_name": "formin-mediated actin nucleation enhancer", "refseq_ac": [ { "id": "NP_013423", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013423", "type": "external" } ], "gene_names_uniprotkb": "BUD6; AIP3; L8543.5", "gene_names_refseq": "AIP3; BUD6", "protein_names_uniprotkb": "Bud site selection protein 6; Actin-interacting protein 3", "protein_names_refseq": "formin-mediated actin nucleation enhancer", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR319C)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "14562106;15665377;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20020052;20702584;21126336;21177495;22218487;23749301;24374639;31362951;31699995;32597660;33481703;33491328;41065574;8657162;9169871;9247651", "class_list": "", "function": "Together with AIP5, assembles filamentous actin (F-actin) to form filament seeds with free barbed ends, and recruits formins to processively elongate and protect these ends from capping protein (PubMed:31362951, PubMed:31699995, PubMed:41065574, PubMed:9247651). Recruits formin BNI1 (PubMed:31362951, PubMed:31699995, PubMed:41065574)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 43, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VYW2", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008047 enzyme activator activity;GO:0005519 cytoskeletal regulatory protein binding", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0051286 cell tip;GO:0005737 cytoplasm;GO:0005816 spindle pole body;GO:0000131 incipient cellular bud site", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0051017 actin filament bundle assembly;GO:0032880 regulation of protein localization;GO:0045010 actin nucleation;GO:0051127 positive regulation of actin nucleation", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P41697-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41735-1", "uniprot_id": [ { "id": "COQ7_YEAST", "url": "https://www.uniprot.org/uniprot/P41735", "type": "external" } ], "mass": 26060.0, "length": 233, "protein_name": "5-demethoxyubiquinone hydroxylase, mitochondrial", "gene_name": "CAT5", "organism": "Yeast", "refseq_name": "putative monooxygenase CAT5", "refseq_ac": [ { "id": "NP_014768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014768", "type": "external" } ], "gene_names_uniprotkb": "CAT5; COQ7; O3284; YOR3284C", "gene_names_refseq": "CAT5; COQ7", "protein_names_uniprotkb": "5-demethoxyubiquinone hydroxylase, mitochondrial; 1.14.13.253; 1.14.99.60; Catabolite repression protein 5; DMQ hydroxylase; NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase; Ubiquinone biosynthesis monooxygenase COQ7", "protein_names_refseq": "putative monooxygenase CAT5", "tax_id": 559292, "disease": "primary coenzyme Q10 deficiency 8 (Disease Ontology:DOID:0070245); autosomal recessive distal hereditary motor neuronopathy 9 (Disease Ontology:DOID:0081428)", "pathway": " (sce:YOR125C); (R-SCE-2142789)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "12748633;14576278;16624818;17391640;19002377;21812761;23940037;24374639;24406904;26497406;8557031;8621692;8904341;9169874;9200815;9452453", "class_list": "", "function": "Catalyzes the hydroxylation of 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis (PubMed:16624818, PubMed:23940037, PubMed:8621692, PubMed:9452453). Also catalyzes the hydroxylation of the 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone at the C6 position and participates in the biosynthesis of ubiquinone (By similarity). Also has a structural role in the COQ enzyme complex, stabilizing COQ3 and COQ4 polypeptides (PubMed:16624818)., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2I3", "ec_number_list": [ { "id": "4.1.1.130", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.130", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.114", "type": "external" }, { "id": "2.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.64", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "1.14.99.60", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.60", "type": "external" }, { "id": "1.14.13.253", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.253", "type": "external" }, { "id": "2.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.201", "type": "external" }, { "id": "3.5.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.-.-", "type": "external" }, { "id": "1.14.15.45", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.45", "type": "external" }, { "id": "1.14.15.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.46", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008682 3-demethoxyubiquinol 3-hydroxylase activity;GO:0004497 monooxygenase activity;GO:0160224 3-demethoxyubiquinone 3-hydroxylase (NADH) activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P41735-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41800-1", "uniprot_id": [ { "id": "MMM1_YEAST", "url": "https://www.uniprot.org/uniprot/P41800", "type": "external" } ], "mass": 48660.0, "length": 426, "protein_name": "Maintenance of mitochondrial morphology protein 1", "gene_name": "MMM1", "organism": "Yeast", "refseq_name": "ERMES complex subunit MMM1", "refseq_ac": [ { "id": "NP_013095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013095", "type": "external" } ], "gene_names_uniprotkb": "MMM1; L1357; YME6", "gene_names_refseq": "MMM1; YME6", "protein_names_uniprotkb": "Maintenance of mitochondrial morphology protein 1; Mitochondrial outer membrane protein MMM1; Yeast mitochondrial escape protein 6", "protein_names_refseq": "ERMES complex subunit MMM1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLL006W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11266455;12454062;12972421;13679517;14562095;14562106;14576278;14981098;16407407;17410204;19556461;22250200;24374639;26370498;27280386;27469264;8089172;8810043;9169871;9628893", "class_list": "", "function": "Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria (PubMed:19556461). Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria (PubMed:27469264, PubMed:8089172, PubMed:9628893). The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex (PubMed:17410204). Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids (PubMed:11266455, PubMed:12454062, PubMed:14981098)., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VXZ7", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0015914 phospholipid transport;GO:0055091 phospholipid homeostasis;GO:0007005 mitochondrion organization;GO:0120009 intermembrane lipid transfer", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P41800-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41805-1", "uniprot_id": [ { "id": "RL10_YEAST", "url": "https://www.uniprot.org/uniprot/P41805", "type": "external" } ], "mass": 25361.0, "length": 221, "protein_name": "Large ribosomal subunit protein uL16", "gene_name": "RPL10", "organism": "Yeast", "refseq_name": "60S ribosomal protein uL16 RPL10", "refseq_ac": [ { "id": "NP_013176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013176", "type": "external" } ], "gene_names_uniprotkb": "RPL10; GRC5; QSR1", "gene_names_refseq": "GRC5; QSR1; RPL10", "protein_names_uniprotkb": "Large ribosomal subunit protein uL16; 60S ribosomal protein L10; L9; Ubiquinol-cytochrome C reductase complex subunit VI-requiring protein", "protein_names_refseq": "60S ribosomal protein uL16 RPL10", "tax_id": 559292, "disease": "syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); syndromic X-linked mental retardation 35 (Disease Ontology:DOID:0080241); spermatogenic failure 63 (Disease Ontology:DOID:0112356); autistic disorder (Disease Ontology:DOID:12849); spondyloepiphyseal dysplasia congenita (Disease Ontology:DOID:14789); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (sce:YLR075W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 23, "publication_id_list": "10601260;11701127;14562095;14976550;17322287;17330950;18407956;19779198;20702584;21109664;22096102;22106047;23749301;24374639;24524803;32597660;33481703;33491328;7730379;8789260;9169871;9301022;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY76", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0006415 translational termination;GO:0006412 translation;GO:0002181 cytoplasmic translation;GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P41805-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41809-1", "uniprot_id": [ { "id": "HKR1_YEAST", "url": "https://www.uniprot.org/uniprot/P41809", "type": "external" } ], "mass": 188948.0, "length": 1802, "protein_name": "Signaling mucin HKR1", "gene_name": "HKR1", "organism": "Yeast", "refseq_name": "Hkr1p", "refseq_ac": [ { "id": "NP_010708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010708", "type": "external" } ], "gene_names_uniprotkb": "HKR1", "gene_names_refseq": "HKR1", "protein_names_uniprotkb": "Signaling mucin HKR1; Hansenula MRAKII killer toxin-resistant protein 1", "protein_names_refseq": "Hkr1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR420W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10564805;19439450;19779198;24374639;33481703;33491328;8113191;8550469;9169867", "class_list": "", "function": "Plasma membrane signaling mucin that promotes activation of the MAPK for the filamentous growth pathway. May regulate beta-glucan synthesis. Overexpression provides resistance to HM-1 killer toxin., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 5, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6VT50;Q04051", "ec_number_list": [], "go_molecular_function": "GO:0005034 osmosensor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030427 site of polarized growth", "go_biological_process": "GO:0006972 hyperosmotic response;GO:0000282 cellular bud site selection;GO:0001402 signal transduction involved in filamentous growth;GO:0006075 (1->3)-beta-D-glucan biosynthetic process;GO:0007232 osmosensory signaling pathway via Sho1 osmosensor", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P41809-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41810-1", "uniprot_id": [ { "id": "COPB_YEAST", "url": "https://www.uniprot.org/uniprot/P41810", "type": "external" } ], "mass": 109019.0, "length": 973, "protein_name": "Coatomer subunit beta", "gene_name": "SEC26", "organism": "Yeast", "refseq_name": "coatomer subunit beta", "refseq_ac": [ { "id": "NP_010524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010524", "type": "external" } ], "gene_names_uniprotkb": "SEC26; YD8419.05C", "gene_names_refseq": "SEC26", "protein_names_uniprotkb": "Coatomer subunit beta; Beta-COP; Beta-coat protein", "protein_names_refseq": "coatomer subunit beta", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR238C); (R-SCE-6798695); (R-SCE-6807878); (R-SCE-6811434)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "14562095;14562106;15356266;16135527;17563356;17954604;18407956;24374639;32597660;33481703;33491328;7929113;9169867", "class_list": "", "function": "The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for mitochondrial morphology., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSL9;Q03779", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030126 COPI vesicle coat", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0008298 intracellular mRNA localization;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P41810-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41812-1", "uniprot_id": [ { "id": "POP1_YEAST", "url": "https://www.uniprot.org/uniprot/P41812", "type": "external" } ], "mass": 100395.0, "length": 875, "protein_name": "Ribonucleases P/MRP protein subunit POP1", "gene_name": "POP1", "organism": "Yeast", "refseq_name": "ribonuclease P/MRP protein subunit POP1", "refseq_ac": [ { "id": "NP_014178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014178", "type": "external" } ], "gene_names_uniprotkb": "POP1; N1285", "gene_names_refseq": "POP1", "protein_names_uniprotkb": "Ribonucleases P/MRP protein subunit POP1; 3.1.26.5; RNA-processing protein POP1; RNases P/MRP 100.4 kDa subunit", "protein_names_refseq": "ribonuclease P/MRP protein subunit POP1", "tax_id": 559292, "disease": "anauxetic dysplasia 2 (Disease Ontology:DOID:0080962)", "pathway": " (sce:YNL221C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562095;14562106;14690591;15637077;18407956;21126336;23749301;24374639;32597660;33481703;33491328;7926742;9169873;9620854", "class_list": "", "function": "Required for processing of 5.8S rRNA (short form) at site A3 and for 5' and 3' processing of pre-tRNA., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0W9", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0004526 ribonuclease P activity", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0005737 cytoplasm;GO:0005697 telomerase holoenzyme complex;GO:0000172 ribonuclease MRP complex", "go_biological_process": "GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent;GO:0008033 tRNA processing;GO:0006364 rRNA processing;GO:0000460 maturation of 5.8S rRNA;GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P41812-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41816-1", "uniprot_id": [ { "id": "OYE3_YEAST", "url": "https://www.uniprot.org/uniprot/P41816", "type": "external" } ], "mass": 44920.0, "length": 400, "protein_name": "NADPH dehydrogenase 3", "gene_name": "OYE3", "organism": "Yeast", "refseq_name": "NADPH dehydrogenase", "refseq_ac": [ { "id": "NP_015154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015154", "type": "external" } ], "gene_names_uniprotkb": "OYE3; P2291", "gene_names_refseq": "OYE3; ZRG6", "protein_names_uniprotkb": "NADPH dehydrogenase 3; 1.6.99.1; Old yellow enzyme 3", "protein_names_refseq": "NADPH dehydrogenase", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL171C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17322287;17897954;24374639;33491328;7836424;8454584;8948103;9169875", "class_list": "", "function": "Flavin-dependent enoate reductase that catalyzes the chemo- and stereoslective hydrogenation of electron-poor alkenes. The enzyme is reduced by NADPH, and oxygen, quinones, and alpha,beta-unsaturated aldehydes and ketones can act as electron acceptors to complete catalytic turnover. The physiological oxidant remains elusive (By similarity). Has a prooxidant activity, increasing reactive oxygen species (ROS) levels when overexpressed. Formation of OYE2-OYE3 heterodimers contribute to the induction of programmed cell death upon oxidative stress (PubMed:17897954)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3J7;E9P937", "ec_number_list": [ { "id": "1.6.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.99.1", "type": "external" } ], "go_molecular_function": "GO:0010181 FMN binding;GO:0003959 NADPH dehydrogenase activity", "go_cellular_component": "", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P41816-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41821-1", "uniprot_id": [ { "id": "MID1_YEAST", "url": "https://www.uniprot.org/uniprot/P41821", "type": "external" } ], "mass": 61575.0, "length": 548, "protein_name": "Stretch-activated cation channel MID1", "gene_name": "MID1", "organism": "Yeast", "refseq_name": "Mid1p", "refseq_ac": [ { "id": "NP_014108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014108", "type": "external" } ], "gene_names_uniprotkb": "MID1; N0530", "gene_names_refseq": "MID1", "protein_names_uniprotkb": "Stretch-activated cation channel MID1; Mating pheromone-induced death protein 2", "protein_names_refseq": "Mid1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL291C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10436155;10958666;11796727;14562106;14697255;14729456;16202999;16223494;16950930;24374639;7526155;8553702;9169873", "class_list": "", "function": "Calcium-permeable, cation-selective stretch-activated channel (SAC) that functions together with CCH1 to mediate calcium entry into cells (PubMed:10436155, PubMed:10958666, PubMed:16223494, PubMed:7526155). Required during mating (PubMed:7526155). Together with CCH1, essential for tolerance to iron stress, which leads to an increased oxidative poise, and to cold stress (PubMed:16223494)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "D6W0Q2", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0015275 stretch-activated, monoatomic cation-selective, calcium channel activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0098703 calcium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P41821-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41833-1", "uniprot_id": [ { "id": "MTA70_YEAST", "url": "https://www.uniprot.org/uniprot/P41833", "type": "external" } ], "mass": 69396.0, "length": 600, "protein_name": "N(6)-adenosine-methyltransferase IME4", "gene_name": "IME4", "organism": "Yeast", "refseq_name": "mRNA (N6-adenosine)-methyltransferase", "refseq_ac": [ { "id": "NP_011323", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011323", "type": "external" } ], "gene_names_uniprotkb": "IME4; G1337; SPO8", "gene_names_refseq": "IME4; SPO8", "protein_names_uniprotkb": "N(6)-adenosine-methyltransferase IME4; 2.1.1.348", "protein_names_refseq": "mRNA (N6-adenosine)-methyltransferase", "tax_id": 559292, "disease": "infertility (Disease Ontology:DOID:5223)", "pathway": " (sce:YGL192W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12384598;1545790;22685417;24269006;24374639;33491328;36930734;9046087;9169869", "class_list": "", "function": "Catalytic component of the MIS complex, a complex that mediates N6-methyladenosine (m6A) methylation of meiotic mRNAs and is required for initiation of meiosis, progression through the meiotic divisions and sporulation (PubMed:12384598, PubMed:22685417, PubMed:24269006, PubMed:36930734). M6A, takes place on the adenosine of 5'-[AG]GAC-3' consensus sites of some mRNAs (PubMed:24269006). Positive regulator for IME2 (PubMed:12384598)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTW2", "ec_number_list": [ { "id": "2.1.1.348", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.348", "type": "external" } ], "go_molecular_function": "GO:0001734 mRNA m(6)A methyltransferase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016556 mRNA modification;GO:0032259 methylation;GO:0051321 meiotic cell cycle;GO:1902974 meiotic DNA replication initiation;GO:0030435 sporulation resulting in formation of a cellular spore", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P41833-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41835-1", "uniprot_id": [ { "id": "THI6_YEAST", "url": "https://www.uniprot.org/uniprot/P41835", "type": "external" } ], "mass": 58059.0, "length": 540, "protein_name": "Thiamine biosynthetic bifunctional enzyme", "gene_name": "THI6", "organism": "Yeast", "refseq_name": "bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase", "refseq_ac": [ { "id": "NP_015110", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015110", "type": "external" } ], "gene_names_uniprotkb": "THI6", "gene_names_refseq": "THI6", "protein_names_uniprotkb": "Thiamine biosynthetic bifunctional enzyme; 4-methyl-5-beta-hydroxyethylthiazole kinase; TH kinase; THZ kinase; TMP pyrophosphorylase; TMP-PPase; Thiamine-phosphate pyrophosphorylase", "protein_names_refseq": "bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL214C)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "24374639;7982968;9169875", "class_list": "", "function": "Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)., [UniProtKB]; Essential for thiamine biosynthesis. The kinase activity is involved in the salvage synthesis of TH-P from the thiazole., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3F6", "ec_number_list": [ { "id": "2.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.3", "type": "external" }, { "id": "2.7.1.50", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.50", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0004417 hydroxyethylthiazole kinase activity;GO:0004789 thiamine-phosphate diphosphorylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009229 thiamine diphosphate biosynthetic process;GO:0009228 thiamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P41835-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41895-1", "uniprot_id": [ { "id": "T2FA_YEAST", "url": "https://www.uniprot.org/uniprot/P41895", "type": "external" } ], "mass": 82194.0, "length": 735, "protein_name": "Transcription initiation factor IIF subunit alpha", "gene_name": "TFG1", "organism": "Yeast", "refseq_name": "transcription factor IIF subunit TFG1", "refseq_ac": [ { "id": "NP_011702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011702", "type": "external" } ], "gene_names_uniprotkb": "TFG1; G7526; SSU71", "gene_names_refseq": "RAP74; SSU71; TFG1", "protein_names_uniprotkb": "Transcription initiation factor IIF subunit alpha; P105; TFIIF large subunit; TFIIF-alpha; Transcription factor G 105 kDa subunit", "protein_names_refseq": "transcription factor IIF subunit TFG1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR186W); (R-SCE-113418); (R-SCE-674695); (R-SCE-6796648); (R-SCE-6807505); (R-SCE-72086); (R-SCE-72203); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-77075); (R-SCE-9018519)", "pathway_count": 13, "publication_count": 28, "publication_id_list": "1331085;14562106;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;24909858;30516470;31208443;32597660;33481703;33491328;33502312;33933450;7724527;7995524;9133739;9169869", "class_list": "", "function": "TFIIF is a general transcription initiation factor that binds to RNA polymerase II. Its functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex, decreasing the affinity of RNA polymerase II for non-specific DNA, allowing for the subsequent recruitment of TFIIE and TFIIH, and facilitating RNA polymerase II elongation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VUW9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0072542 protein phosphatase activator activity;GO:0001096 TFIIF-class transcription factor complex binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005674 transcription factor TFIIF complex", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P41895-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41901-1", "uniprot_id": [ { "id": "SPR3_YEAST", "url": "https://www.uniprot.org/uniprot/P41901", "type": "external" } ], "mass": 59845.0, "length": 512, "protein_name": "Sporulation-regulated protein 3", "gene_name": "SPR3", "organism": "Yeast", "refseq_name": "septin SPR3", "refseq_ac": [ { "id": "NP_011573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011573", "type": "external" } ], "gene_names_uniprotkb": "SPR3", "gene_names_refseq": "SPR3", "protein_names_uniprotkb": "Sporulation-regulated protein 3", "protein_names_refseq": "septin SPR3", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR059W); (R-SCE-111457)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "24374639;7590307;8636217;8885406;9169869", "class_list": "", "function": "Septins are GTPases involved in cytokinesis that assemble into filaments and form a ring at the cleavage site. May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage. Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUJ4", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005940 septin ring;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0031105 septin complex;GO:0032153 cell division site", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis;GO:0030437 ascospore formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P41901-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41903-1", "uniprot_id": [ { "id": "PTE1_YEAST", "url": "https://www.uniprot.org/uniprot/P41903", "type": "external" } ], "mass": 40260.0, "length": 349, "protein_name": "Peroxisomal acyl-coenzyme A thioester hydrolase 1", "gene_name": "TES1", "organism": "Yeast", "refseq_name": "palmitoyl-CoA hydrolase", "refseq_ac": [ { "id": "NP_012553", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012553", "type": "external" } ], "gene_names_uniprotkb": "TES1; J1456; PTE1", "gene_names_refseq": "PTE1; TES1", "protein_names_uniprotkb": "Peroxisomal acyl-coenzyme A thioester hydrolase 1; 3.1.2.2; Peroxisomal long-chain acyl-CoA thioesterase 1", "protein_names_refseq": "palmitoyl-CoA hydrolase", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR019C); (R-SCE-193368); (R-SCE-2046106); (R-SCE-389887); (R-SCE-390247); (R-SCE-9033241)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "10092594;24374639;8641269", "class_list": "", "function": "Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Contributes to growth on fatty acids., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWJ4", "ec_number_list": [ { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.4", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.56", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" } ], "go_molecular_function": "GO:0047617 fatty acyl-CoA hydrolase activity;GO:0052689 carboxylic ester hydrolase activity;GO:0008474 palmitoyl-(protein) hydrolase activity;GO:0052816 long-chain fatty acyl-CoA hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0006637 acyl-CoA metabolic process;GO:0009062 fatty acid catabolic process;GO:0019395 fatty acid oxidation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P41903-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41911-1", "uniprot_id": [ { "id": "GPD2_YEAST", "url": "https://www.uniprot.org/uniprot/P41911", "type": "external" } ], "mass": 49422.0, "length": 440, "protein_name": "Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, mitochondrial", "gene_name": "GPD2", "organism": "Yeast", "refseq_name": "glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2", "refseq_ac": [ { "id": "NP_014582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014582", "type": "external" } ], "gene_names_uniprotkb": "GPD2; GPD3; O1222", "gene_names_refseq": "GPD2; GPD3", "protein_names_uniprotkb": "Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, mitochondrial; 1.1.1.8", "protein_names_refseq": "glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2", "tax_id": 559292, "disease": "Brugada syndrome 2 (Disease Ontology:DOID:0110219)", "pathway": " (sce:YOL059W); (R-SCE-1483166)", "pathway_count": 2, "publication_count": 28, "publication_id_list": "11875433;14562095;14562106;14576278;15210723;15665377;17287358;17322287;17330950;17563356;18407956;19684113;19779198;20702584;21126336;21177495;22218487;23749301;24374639;27821475;32597660;33481703;33491328;7476212;8789261;8979347;9169874;9171333", "class_list": "", "function": "Catalyzes the production of glycerol under anaerobic growth conditions. Glycerol production serves as a redox sink by consuming the excess cytosolic NADH during anaerobic metabolism., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W208;P50905", "ec_number_list": [ { "id": "1.1.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.8", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051287 NAD binding;GO:0047952 glycerol-3-phosphate dehydrogenase [NAD(P)+] activity;GO:0141152 glycerol-3-phosphate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006071 glycerol metabolic process;GO:0006072 glycerol-3-phosphate metabolic process;GO:0046168 glycerol-3-phosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P41911-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41920-1", "uniprot_id": [ { "id": "YRB1_YEAST", "url": "https://www.uniprot.org/uniprot/P41920", "type": "external" } ], "mass": 22953.0, "length": 201, "protein_name": "Ran-specific GTPase-activating protein 1", "gene_name": "YRB1", "organism": "Yeast", "refseq_name": "Ran GTPase-binding protein YRB1", "refseq_ac": [ { "id": "NP_010285", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010285", "type": "external" } ], "gene_names_uniprotkb": "YRB1; CST20; HTN1; SFO1; YD8119.08", "gene_names_refseq": "CST20; HTN1; SFO1; STP52; YRB1", "protein_names_uniprotkb": "Ran-specific GTPase-activating protein 1; Chromosome stability protein 20; Perinuclear array-localized protein; RANBP1; Ran-binding protein 1", "protein_names_refseq": "Ran GTPase-binding protein YRB1", "tax_id": 559292, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); dilated cardiomyopathy (Disease Ontology:DOID:12930); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (sce:YDR002W)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10825193;17287358;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;24909858;32597660;33481703;33491328;7489726;7836422;7948031;8444853;9169867", "class_list": "", "function": "Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1 and GSP2., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRY9", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005737 cytoplasm", "go_biological_process": "GO:0000082 G1/S transition of mitotic cell cycle;GO:0051168 nuclear export;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0006405 RNA export from nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P41920-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41921-1", "uniprot_id": [ { "id": "GSHR_YEAST", "url": "https://www.uniprot.org/uniprot/P41921", "type": "external" } ], "mass": 53441.0, "length": 483, "protein_name": "Glutathione reductase", "gene_name": "GLR1", "organism": "Yeast", "refseq_name": "glutathione-disulfide reductase GLR1", "refseq_ac": [ { "id": "NP_015234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015234", "type": "external" } ], "gene_names_uniprotkb": "GLR1; LPG17W", "gene_names_refseq": "GLR1; LPG17", "protein_names_uniprotkb": "Glutathione reductase; 1.8.1.7; GRase; GR", "protein_names_refseq": "glutathione-disulfide reductase GLR1", "tax_id": 559292, "disease": "hemorrhagic cystitis (Disease Ontology:DOID:0050859); congenital nonspherocytic hemolytic anemia 10 (Disease Ontology:DOID:0051009); myoglobinuria (Disease Ontology:DOID:0080108); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Parkinsonism (Disease Ontology:DOID:0080855); Heinz body anemia (Disease Ontology:DOID:0111363); lymphoid leukemia (Disease Ontology:DOID:1037); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); osteoporosis (Disease Ontology:DOID:11476); diabetic angiopathy (Disease Ontology:DOID:11713); limb-girdle muscular dystrophy (Disease Ontology:DOID:11724); iron deficiency anemia (Disease Ontology:DOID:11758); beta thalassemia (Disease Ontology:DOID:12241); acute kidney tubular necrosis (Disease Ontology:DOID:12556); Huntington's disease (Disease Ontology:DOID:12858); dementia (Disease Ontology:DOID:1307); diabetic cataract (Disease Ontology:DOID:13328); transient cerebral ischemia (Disease Ontology:DOID:224); acute kidney failure (Disease Ontology:DOID:3021); coronary artery disease (Disease Ontology:DOID:3393); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); myocardial infarction (Disease Ontology:DOID:5844); nephrolithiasis (Disease Ontology:DOID:585); congenital hemolytic anemia (Disease Ontology:DOID:589); peptic ulcer disease (Disease Ontology:DOID:750); end stage renal disease (Disease Ontology:DOID:783); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); alcoholic gastritis (Disease Ontology:DOID:8680); polycythemia vera (Disease Ontology:DOID:8997); acute myeloid leukemia (Disease Ontology:DOID:9119); diabetes mellitus (Disease Ontology:DOID:9351); senile cataract (Disease Ontology:DOID:9669); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (sce:YPL091W); (R-SCE-3299685); (R-SCE-499943); (R-SCE-5628897)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "14562095;14562106;16823961;17554778;18407956;19049979;21126336;22814378;23242256;23613772;24374639;32597660;33481703;33491328;36164978;7737505;9169875", "class_list": "", "function": "Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 36, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W3S6", "ec_number_list": [ { "id": "1.8.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.7", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0050661 NADP binding;GO:0004362 glutathione-disulfide reductase (NADPH) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0045454 cell redox homeostasis;GO:0006749 glutathione metabolic process;GO:0010731 protein glutathionylation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P41921-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.1000100000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41939-1", "uniprot_id": [ { "id": "IDHC_YEAST", "url": "https://www.uniprot.org/uniprot/P41939", "type": "external" } ], "mass": 46562.0, "length": 412, "protein_name": "Isocitrate dehydrogenase [NADP] cytoplasmic", "gene_name": "IDP2", "organism": "Yeast", "refseq_name": "isocitrate dehydrogenase (NADP(+)) IDP2", "refseq_ac": [ { "id": "NP_013275", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013275", "type": "external" } ], "gene_names_uniprotkb": "IDP2; L9470.12", "gene_names_refseq": "IDP2", "protein_names_uniprotkb": "Isocitrate dehydrogenase [NADP] cytoplasmic; 1.1.1.42; IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase", "protein_names_refseq": "isocitrate dehydrogenase (NADP(+)) IDP2", "tax_id": 559292, "disease": "D-2-hydroxyglutaric aciduria (Disease Ontology:DOID:0050575); myelodysplastic syndrome (Disease Ontology:DOID:0050908); bone remodeling disease (Disease Ontology:DOID:0080005); D-2-hydroxyglutaric aciduria 2 (Disease Ontology:DOID:0111352); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); cancer (Disease Ontology:DOID:162); status epilepticus (Disease Ontology:DOID:1824); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); autoimmune disease (Disease Ontology:DOID:417); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); hepatocellular clear cell carcinoma (Disease Ontology:DOID:5016); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (sce:YLR174W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;22814378;24374639;33491328;8068643;9169871", "class_list": "", "function": "May function in the production of NADPH for fatty acid and sterol synthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYH8", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0051287 NAD binding;GO:0004450 isocitrate dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0006099 tricarboxylic acid cycle;GO:0006102 isocitrate metabolic process;GO:0006097 glyoxylate cycle", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P41939-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41948-1", "uniprot_id": [ { "id": "MEP2_YEAST", "url": "https://www.uniprot.org/uniprot/P41948", "type": "external" } ], "mass": 53401.0, "length": 499, "protein_name": "Ammonium transporter MEP2", "gene_name": "MEP2", "organism": "Yeast", "refseq_name": "ammonium permease MEP2", "refseq_ac": [ { "id": "NP_014257", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014257", "type": "external" } ], "gene_names_uniprotkb": "MEP2; AMT2; N1207; N1820", "gene_names_refseq": "MEP2", "protein_names_uniprotkb": "Ammonium transporter MEP2", "protein_names_refseq": "ammonium permease MEP2", "tax_id": 559292, "disease": "Rh deficiency syndrome (Disease Ontology:DOID:0050641); metabolic acidosis (Disease Ontology:DOID:0050758); overhydrated hereditary stomatocytosis (Disease Ontology:DOID:0111562); kidney failure (Disease Ontology:DOID:1074); renal tubular acidosis (Disease Ontology:DOID:14219); Rh isoimmunization (Disease Ontology:DOID:4175); hypokalemia (Disease Ontology:DOID:4500); hemolytic anemia (Disease Ontology:DOID:583)", "pathway": " (sce:YNL142W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11069679;11486013;16477434;16847258;18434596;20702584;24374639;24476960;27088325;27821475;32069286;33481703;33491328;34965436;8619318;9169873;9234685;9482721", "class_list": "", "function": "Transporter for ammonium (both charged and uncharged NH3 and NH4) to use as a nitrogen source (PubMed:11069679, PubMed:11486013, PubMed:16477434, PubMed:18434596, PubMed:24476960, PubMed:27088325, PubMed:9234685, PubMed:9482721). The affinity of MEP2 is about twenty times higher than that of MEP1 (PubMed:9482721). MEP3 has the lowest affinity (PubMed:9482721). Under ammonium limitation acts as an ammonium sensor, generating a signal that leads to pseudohyphal (filamentous) growth (PubMed:11069679, PubMed:16477434, PubMed:18434596, PubMed:32069286, PubMed:9482721)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W140", "ec_number_list": [], "go_molecular_function": "GO:0008519 ammonium channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0072488 ammonium transmembrane transport;GO:1900430 positive regulation of filamentous growth of a population of unicellular organisms;GO:0007124 pseudohyphal growth;GO:0019740 nitrogen utilization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P41948-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42835-1", "uniprot_id": [ { "id": "EGT2_YEAST", "url": "https://www.uniprot.org/uniprot/P42835", "type": "external" } ], "mass": 108525.0, "length": 1041, "protein_name": "Protein EGT2", "gene_name": "EGT2", "organism": "Yeast", "refseq_name": "Egt2p", "refseq_ac": [ { "id": "NP_014072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014072", "type": "external" } ], "gene_names_uniprotkb": "EGT2; N0320", "gene_names_refseq": "EGT2", "protein_names_uniprotkb": "Protein EGT2; Early G1 transcript 2", "protein_names_refseq": "Egt2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL327W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15452134;16086015;24374639;7645347;8668141;9169873;9613572", "class_list": "", "function": "Seems to be involved in the correct timing of cell separation after cytokinesis, as separation of mutant daughter cells is delayed. Could either be an enzyme necessary for glucans-degradation of the cell wall at the neck region between mother and daughter cells or a regulatory protein controlling this metabolic step., [UniProtKB, PubMed]", "predicted_glycosites": 19, "predicted_n_glycosites": 19, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "D6W0M0", "ec_number_list": [], "go_molecular_function": "GO:0008810 cellulase activity", "go_cellular_component": "GO:0030428 cell septum;GO:0000324 fungal-type vacuole;GO:0005621 cellular bud scar;GO:0005933 cellular bud;GO:0009277 fungal-type cell wall", "go_biological_process": "GO:0000920 septum digestion after cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P42835-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42836-1", "uniprot_id": [ { "id": "PFA3_YEAST", "url": "https://www.uniprot.org/uniprot/P42836", "type": "external" } ], "mass": 39184.0, "length": 336, "protein_name": "Palmitoyltransferase PFA3", "gene_name": "PFA3", "organism": "Yeast", "refseq_name": "palmitoyltransferase PFA3", "refseq_ac": [ { "id": "NP_014073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014073", "type": "external" } ], "gene_names_uniprotkb": "PFA3; N0325", "gene_names_refseq": "PFA3", "protein_names_uniprotkb": "Palmitoyltransferase PFA3; 2.3.1.225; Protein fatty acyltransferase 3", "protein_names_refseq": "palmitoyltransferase PFA3", "tax_id": 559292, "disease": "syndrome (Disease Ontology:DOID:225)", "pathway": " (sce:YNL326C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;16186255;16847258;19779198;23749301;24374639;32597660;33481703;33491328;7645347;9169873", "class_list": "", "function": "Palmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W0M1", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005774 vacuolar membrane;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0042144 vacuole fusion, non-autophagic;GO:0006612 protein targeting to membrane;GO:0018345 protein palmitoylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P42836-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42839-1", "uniprot_id": [ { "id": "VNX1_YEAST", "url": "https://www.uniprot.org/uniprot/P42839", "type": "external" } ], "mass": 102499.0, "length": 908, "protein_name": "Low affinity vacuolar monovalent cation/H(+) antiporter", "gene_name": "VNX1", "organism": "Yeast", "refseq_name": "calcium/hydrogen antiporter", "refseq_ac": [ { "id": "NP_014078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014078", "type": "external" } ], "gene_names_uniprotkb": "VNX1; N0339", "gene_names_refseq": "VNX1", "protein_names_uniprotkb": "Low affinity vacuolar monovalent cation/H(+) antiporter; Vacuolar Na(+)/H(+) exchanger", "protein_names_refseq": "calcium/hydrogen antiporter", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL321W)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "11875433;14562106;16847258;17330950;17563356;17588950;18407956;19520826;19684113;19779198;19795423;19823750;21177495;22814378;23749301;24374639;32597660;33229814;33481703;33491328;34965436;7502583;9169873", "class_list": "", "function": "Has a role in promoting intracellular monovalent cation sequestration via the exchange of monovalent cations and especially Na(+) for hydrogen ions across the vacuolar membrane., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 13, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "D6W0M5", "ec_number_list": [], "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015386 potassium:proton antiporter activity;GO:0015369 calcium:proton antiporter activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole;GO:1990816 vacuole-mitochondrion membrane contact site", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0006813 potassium ion transport;GO:0070588 calcium ion transmembrane transport;GO:0006814 sodium ion transport;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P42839-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42843-1", "uniprot_id": [ { "id": "SKP2_YEAST", "url": "https://www.uniprot.org/uniprot/P42843", "type": "external" } ], "mass": 88942.0, "length": 763, "protein_name": "F-box protein SKP2", "gene_name": "SKP2", "organism": "Yeast", "refseq_name": "putative SCF ubiquitin ligase complex subunit SKP2", "refseq_ac": [ { "id": "NP_014088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014088", "type": "external" } ], "gene_names_uniprotkb": "SKP2; N0376", "gene_names_refseq": "SKP2", "protein_names_uniprotkb": "F-box protein SKP2", "protein_names_refseq": "putative SCF ubiquitin ligase complex subunit SKP2", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL311C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562095;14562106;14747994;16432255;16702403;17322287;19779198;20936605;21126336;24374639;33481703;33491328;7502583;9169873", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). Regulates protein levels of sulfur metabolism enzymes. The SCF(SKP2) complex may regulate some transcription factors or regulators of cysteine and methionine biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W0N4;Q6B2L9", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0030163 protein catabolic process;GO:1901494 regulation of cysteine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P42843-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42844-1", "uniprot_id": [ { "id": "ZIM17_YEAST", "url": "https://www.uniprot.org/uniprot/P42844", "type": "external" } ], "mass": 19855.0, "length": 174, "protein_name": "Mitochondrial protein import protein ZIM17", "gene_name": "ZIM17", "organism": "Yeast", "refseq_name": "Zim17p", "refseq_ac": [ { "id": "NP_014089", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014089", "type": "external" } ], "gene_names_uniprotkb": "ZIM17; FMP28; HEP1; N0381; TIM15", "gene_names_refseq": "HEP1; TIM15; ZIM17", "protein_names_uniprotkb": "Mitochondrial protein import protein ZIM17; MMC; Mitochondrial import inner membrane translocase subunit TIM15; mtHsp70 escort protein 1; mtHsp70-associated motor and chaperone protein TIM15/ZIM17", "protein_names_refseq": "Zim17p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL310C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12748633;14562095;14562106;14576278;15383543;15642367;15719019;15992824;17322287;17571076;24374639;7502583;9169873", "class_list": "", "function": "Involved in protein import into mitochondria. Acts as a Hsp70-specific chaperone that prevents self-aggregation of the matrix Hsp70 chaperones SSC1 (mtHSP70) and SSQ1, thereby maintaining their function in mitochondrial protein import and Fe/S protein biosynthesis. May act together with PAM18 as co-chaperone to facilitate recognition and folding of imported proteins by SSC1 in the mitochondrial matrix., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0N5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0007005 mitochondrion organization;GO:0006986 response to unfolded protein;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P42844-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42845-1", "uniprot_id": [ { "id": "STB1_YEAST", "url": "https://www.uniprot.org/uniprot/P42845", "type": "external" } ], "mass": 45684.0, "length": 420, "protein_name": "Protein STB1", "gene_name": "STB1", "organism": "Yeast", "refseq_name": "Stb1p", "refseq_ac": [ { "id": "NP_014090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014090", "type": "external" } ], "gene_names_uniprotkb": "STB1; N0384", "gene_names_refseq": "STB1", "protein_names_uniprotkb": "Protein STB1; SIN3-binding protein 1", "protein_names_refseq": "Stb1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL309W)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10409718;12748633;12832490;14562095;14562106;14574415;15665377;17287358;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21177495;22218487;23749301;24374639;27821475;32597660;33229814;33481703;33491328;7502583;9169873;9393435", "class_list": "", "function": "Involved in the regulation and timing of MBF-dependent transcription in late G1 of the cell cycle., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 29, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "D6W0N6", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0070822 Sin3-type complex;GO:0030907 MBF transcription complex;GO:0033309 SBF transcription complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000082 G1/S transition of mitotic cell cycle;GO:0031496 positive regulation of mating type switching", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P42845-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42884-1", "uniprot_id": [ { "id": "AAD14_YEAST", "url": "https://www.uniprot.org/uniprot/P42884", "type": "external" } ], "mass": 41991.0, "length": 376, "protein_name": "Putative aryl-alcohol dehydrogenase AAD14", "gene_name": "AAD14", "organism": "Yeast", "refseq_name": "putative aryl-alcohol dehydrogenase", "refseq_ac": [ { "id": "NP_014068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014068", "type": "external" } ], "gene_names_uniprotkb": "AAD14; N0300", "gene_names_refseq": "AAD14", "protein_names_uniprotkb": "Putative aryl-alcohol dehydrogenase AAD14; 1.1.1.-", "protein_names_refseq": "putative aryl-alcohol dehydrogenase", "tax_id": 559292, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498)", "pathway": " (sce:YNL331C)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "24374639;33491328;8533474;9169873", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0L6", "ec_number_list": [], "go_molecular_function": "GO:0047681 aryl-alcohol dehydrogenase (NADP+) activity", "go_cellular_component": "", "go_biological_process": "GO:0006081 aldehyde metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P42884-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42945-1", "uniprot_id": [ { "id": "UTP10_YEAST", "url": "https://www.uniprot.org/uniprot/P42945", "type": "external" } ], "mass": 200082.0, "length": 1769, "protein_name": "U3 small nucleolar RNA-associated protein 10", "gene_name": "UTP10", "organism": "Yeast", "refseq_name": "snoRNA-binding rRNA-processing protein UTP10", "refseq_ac": [ { "id": "NP_012426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012426", "type": "external" } ], "gene_names_uniprotkb": "UTP10; J0808", "gene_names_refseq": "UTP10", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 10; U three protein 10; U3 protein 10 required for transcription; U3 snoRNA-associated protein 10; t-UTP10", "protein_names_refseq": "snoRNA-binding rRNA-processing protein UTP10", "tax_id": 559292, "disease": "glioblastoma (Disease Ontology:DOID:3068); pancreatic ductal carcinoma (Disease Ontology:DOID:3587)", "pathway": " (sce:YJL109C); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "12068309;14562095;14562106;14576278;15489292;16544271;17652137;18407956;21126336;22814378;24374639;33481703;33491328;7483851;8641269", "class_list": "", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs). Involved in ribosome biosynthesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW75", "ec_number_list": [], "go_molecular_function": "GO:0030515 snoRNA binding;GO:0034511 U3 snoRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0033553 rDNA heterochromatin;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0045943 positive regulation of transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P42945-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42951-1", "uniprot_id": [ { "id": "LSB6_YEAST", "url": "https://www.uniprot.org/uniprot/P42951", "type": "external" } ], "mass": 70217.0, "length": 607, "protein_name": "Phosphatidylinositol 4-kinase LSB6", "gene_name": "LSB6", "organism": "Yeast", "refseq_name": "1-phosphatidylinositol 4-kinase LSB6", "refseq_ac": [ { "id": "NP_012435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012435", "type": "external" } ], "gene_names_uniprotkb": "LSB6; J0834", "gene_names_refseq": "LSB6", "protein_names_uniprotkb": "Phosphatidylinositol 4-kinase LSB6; 2.7.1.67; LAS seventeen-binding protein 6; LAS17-binding protein 6; PI4-kinase; PtdIns-4-kinase", "protein_names_refseq": "1-phosphatidylinositol 4-kinase LSB6", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL100W); (R-SCE-1483248); (R-SCE-1660499); (R-SCE-1660514); (R-SCE-1660516)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "12361950;12523934;14562106;24374639;32597660;33481703;33491328;7483851;8641269", "class_list": "", "function": "May play a role in endocytic and/or exocytic pathways., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW84", "ec_number_list": [ { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004430 1-phosphatidylinositol 4-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005802 trans-Golgi network;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0007032 endosome organization;GO:0007030 Golgi organization;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P42951-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43122-1", "uniprot_id": [ { "id": "QRI7_YEAST", "url": "https://www.uniprot.org/uniprot/P43122", "type": "external" } ], "mass": 45543.0, "length": 407, "protein_name": "tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial", "gene_name": "QRI7", "organism": "Yeast", "refseq_name": "putative N(6)-L-threonylcarbamoyladenine synthase", "refseq_ac": [ { "id": "NP_010179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010179", "type": "external" } ], "gene_names_uniprotkb": "QRI7; D2366", "gene_names_refseq": "QRI7", "protein_names_uniprotkb": "tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; 2.3.1.234; N6-L-threonylcarbamoyladenine synthase; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein QRI7; tRNA threonylcarbamoyladenosine biosynthesis protein QRI7", "protein_names_refseq": "putative N(6)-L-threonylcarbamoyladenine synthase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL104C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;16823961;19578062;21183954;21285948;23620299;24374639;25084372;7725801;8896274;9169867", "class_list": "", "function": "Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance., [UniProtKB, HAMAP, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRP6", "ec_number_list": [ { "id": "2.3.1.234", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.234", "type": "external" } ], "go_molecular_function": "GO:0008252 nucleotidase activity;GO:0046872 metal ion binding;GO:0000049 tRNA binding;GO:0061711 tRNA N(6)-L-threonylcarbamoyladenine synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0002949 tRNA threonylcarbamoyladenosine modification;GO:0072670 mitochondrial tRNA threonylcarbamoyladenosine modification", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P43122-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43123-1", "uniprot_id": [ { "id": "UAP1_YEAST", "url": "https://www.uniprot.org/uniprot/P43123", "type": "external" } ], "mass": 53476.0, "length": 477, "protein_name": "UDP-N-acetylglucosamine pyrophosphorylase", "gene_name": "QRI1", "organism": "Yeast", "refseq_name": "UDP-N-acetylglucosamine diphosphorylase", "refseq_ac": [ { "id": "NP_010180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010180", "type": "external" } ], "gene_names_uniprotkb": "QRI1; D2362; UAP1", "gene_names_refseq": "QRI1; UAP1", "protein_names_uniprotkb": "UDP-N-acetylglucosamine pyrophosphorylase; 2.7.7.23", "protein_names_refseq": "UDP-N-acetylglucosamine diphosphorylase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL103C); (R-SCE-446210)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14562106;18407956;19779198;24374639;33491328;7725801;8896274;9169867;9603950", "class_list": "", "function": "UDP-N-acetylglucosamine pyrophosphorylase that utilizes N-acetylglucosamine-1-phosphate as substrate (PubMed:9603950). Together with AGM1, is involved in the production of UDP-N-acetylglucosamine from N-acetylglucosamine-6-phosphate (PubMed:9603950)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRP7", "ec_number_list": [ { "id": "2.7.7.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.23", "type": "external" } ], "go_molecular_function": "GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006048 UDP-N-acetylglucosamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P43123-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43132-1", "uniprot_id": [ { "id": "BRE2_YEAST", "url": "https://www.uniprot.org/uniprot/P43132", "type": "external" } ], "mass": 58347.0, "length": 505, "protein_name": "COMPASS component BRE2", "gene_name": "BRE2", "organism": "Yeast", "refseq_name": "Bre2p", "refseq_ac": [ { "id": "NP_013115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013115", "type": "external" } ], "gene_names_uniprotkb": "BRE2; CPS60", "gene_names_refseq": "BRE2; CPS60", "protein_names_uniprotkb": "COMPASS component BRE2; Brefeldin-A sensitivity protein 2; COMPASS protein 60; Complex proteins associated with SET1 protein BRE2; Set1C component BRE2", "protein_names_refseq": "Bre2p", "tax_id": 559292, "disease": "congenital heart disease (Disease Ontology:DOID:1682); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (sce:YLR015W); (R-SCE-9772755)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "11169758;11687631;11742990;11805083;14562106;17563356;18407956;19795423;19823750;21126336;23749301;24374639;25542209;29071121;30100186;31922488;33481703;33491328;7874498;9169871", "class_list": "", "function": "Component of the Set1C/COMPASS complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation (PubMed:11742990, PubMed:11805083). COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face (PubMed:31922488)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY17;E9PA88", "ec_number_list": [], "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0048188 Set1C/COMPASS complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0000723 telomere maintenance", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P43132-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43321-1", "uniprot_id": [ { "id": "SMD3_YEAST", "url": "https://www.uniprot.org/uniprot/P43321", "type": "external" } ], "mass": 11224.0, "length": 101, "protein_name": "Small nuclear ribonucleoprotein Sm D3", "gene_name": "SMD3", "organism": "Yeast", "refseq_name": "mRNA splicing protein SMD3", "refseq_ac": [ { "id": "NP_013248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013248", "type": "external" } ], "gene_names_uniprotkb": "SMD3; L9634.6", "gene_names_refseq": "SLT16; SMD3", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein Sm D3; Sm-D3; snRNP core protein D3", "protein_names_refseq": "mRNA splicing protein SMD3", "tax_id": 559292, "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (sce:YLR147C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10369684;10449419;10490028;11302706;11804584;11884590;14690591;17322287;1840635;1944264;24374639;7527560;7799953;9012791;9169871;9528767", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Also binds telomerase RNA and is required for its accumulation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYE2;E9P8W3", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0036261 7-methylguanosine cap hypermethylation;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P43321-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43497-1", "uniprot_id": [ { "id": "CWP2_YEAST", "url": "https://www.uniprot.org/uniprot/P43497", "type": "external" } ], "mass": 8911.0, "length": 92, "protein_name": "Cell wall protein CWP2", "gene_name": "CWP2", "organism": "Yeast", "refseq_name": "Cwp2p", "refseq_ac": [ { "id": "NP_012826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012826", "type": "external" } ], "gene_names_uniprotkb": "CWP2; LPR1; YKL096BW; YKL444", "gene_names_refseq": "CWP2; LPR1; YKL097W-A", "protein_names_uniprotkb": "Cell wall protein CWP2; Low pH resistance protein 1", "protein_names_refseq": "Cwp2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL096W-A)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11292809;14562106;14617149;16672383;17322287;24374639;7768807;8196765;8256524", "class_list": "", "function": "Component of the cell wall., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXJ1", "ec_number_list": [], "go_molecular_function": "GO:0005199 structural constituent of cell wall", "go_cellular_component": "GO:0005829 cytosol;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P43497-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43534-1", "uniprot_id": [ { "id": "THI5_YEAST", "url": "https://www.uniprot.org/uniprot/P43534", "type": "external" } ], "mass": 38592.0, "length": 340, "protein_name": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5", "gene_name": "THI5", "organism": "Yeast", "refseq_name": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase", "refseq_ac": [ { "id": "NP_116597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116597", "type": "external" } ], "gene_names_uniprotkb": "THI5; MOL2", "gene_names_refseq": "THI5", "protein_names_uniprotkb": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5; 2.-.-.-; HMP-P synthase; Hydroxymethylpyrimidine phosphate synthase; Thiamine biosynthesis protein 5; Thiamine pyrimidine synthase", "protein_names_refseq": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase", "tax_id": 559292, "disease": "", "pathway": " (sce:YFL058W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12777485;18388401;23048037;24374639;7670463;8528151", "class_list": "", "function": "Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTH2", "ec_number_list": [ { "id": "2.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0106344 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP", "go_cellular_component": "", "go_biological_process": "GO:0009229 thiamine diphosphate biosynthetic process;GO:0009228 thiamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P43534-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43555-1", "uniprot_id": [ { "id": "EMP47_YEAST", "url": "https://www.uniprot.org/uniprot/P43555", "type": "external" } ], "mass": 50330.0, "length": 445, "protein_name": "Protein EMP47", "gene_name": "EMP47", "organism": "Yeast", "refseq_name": "Emp47p", "refseq_ac": [ { "id": "NP_116606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116606", "type": "external" } ], "gene_names_uniprotkb": "EMP47", "gene_names_refseq": "EMP47", "protein_names_uniprotkb": "Protein EMP47; 47 kDa endomembrane protein; Endosomal P44 protein", "protein_names_refseq": "Emp47p", "tax_id": 559292, "disease": "autosomal dominant intellectual developmental disorder 69 (Disease Ontology:DOID:0061042); autosomal recessive intellectual developmental disorder 52 (Disease Ontology:DOID:0081215); factor XIII deficiency (Disease Ontology:DOID:2211); factor V deficiency (Disease Ontology:DOID:2216)", "pathway": " (sce:YFL048C); (R-SCE-9013106)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12134087;12857885;14562106;14627716;16439369;17322287;24374639;7490292;7670463;8314797", "class_list": "", "function": "Involved in the secretion of glycoproteins and in nucleus architecture and gene silencing. Required for the endoplasmic reticulum exit of EMP46., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTI2", "ec_number_list": [], "go_molecular_function": "GO:0005537 D-mannose binding;GO:0097367 carbohydrate derivative binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P43555-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43558-1", "uniprot_id": [ { "id": "OTU1_YEAST", "url": "https://www.uniprot.org/uniprot/P43558", "type": "external" } ], "mass": 33510.0, "length": 301, "protein_name": "Ubiquitin thioesterase OTU1", "gene_name": "OTU1", "organism": "Yeast", "refseq_name": "ubiquitin-specific protease OTU1", "refseq_ac": [ { "id": "NP_116610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116610", "type": "external" } ], "gene_names_uniprotkb": "OTU1", "gene_names_refseq": "OTU1", "protein_names_uniprotkb": "Ubiquitin thioesterase OTU1; 3.4.19.12; OTU domain-containing protein 1", "protein_names_refseq": "ubiquitin-specific protease OTU1", "tax_id": 559292, "disease": "", "pathway": " (sce:YFL044C); (R-SCE-5689896)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14562095;14562106;15755922;16427015;19779198;22106047;24374639;33491328;7670463", "class_list": "", "function": "Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Participates in the regulation of the ubiquitin conjugation pathway involving CDC48 by hindering multiubiquitination of substrates at the CDC48 chaperone. May be indirectly involved in PIS1 gene expression., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTI6", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016579 protein deubiquitination;GO:0006355 regulation of DNA-templated transcription;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P43558-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43561-1", "uniprot_id": [ { "id": "FET5_YEAST", "url": "https://www.uniprot.org/uniprot/P43561", "type": "external" } ], "mass": 70880.0, "length": 622, "protein_name": "Iron transport multicopper oxidase FET5", "gene_name": "FET5", "organism": "Yeast", "refseq_name": "ferroxidase FET5", "refseq_ac": [ { "id": "NP_116612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116612", "type": "external" } ], "gene_names_uniprotkb": "FET5", "gene_names_refseq": "FET5", "protein_names_uniprotkb": "Iron transport multicopper oxidase FET5; 1.-.-.-", "protein_names_refseq": "ferroxidase FET5", "tax_id": 559292, "disease": "", "pathway": " (sce:YFL041W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10608875;14562106;19779198;24374639;7670463;9413439", "class_list": "", "function": "Iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake. May be required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport., [UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "D6VTI9", "ec_number_list": [], "go_molecular_function": "GO:0005507 copper ion binding;GO:0004322 ferroxidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:1902495 transmembrane transporter complex;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0034755 iron ion transmembrane transport;GO:0006879 intracellular iron ion homeostasis;GO:0006826 iron ion transport;GO:0010106 cellular response to iron ion starvation;GO:0033215 reductive iron assimilation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P43561-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43563-1", "uniprot_id": [ { "id": "MOB2_YEAST", "url": "https://www.uniprot.org/uniprot/P43563", "type": "external" } ], "mass": 33276.0, "length": 287, "protein_name": "CBK1 kinase activator protein MOB2", "gene_name": "MOB2", "organism": "Yeast", "refseq_name": "Mob2p", "refseq_ac": [ { "id": "NP_116618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116618", "type": "external" } ], "gene_names_uniprotkb": "MOB2; YFL035C-A; YFL035C", "gene_names_refseq": "MOB2; YFL035C-A; YFL035C", "protein_names_uniprotkb": "CBK1 kinase activator protein MOB2; MPS1 binder 2; Maintenance of ploidy protein MOB2", "protein_names_refseq": "Mob2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YFL034C-B)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "11747810;12196508;14562106;16934835;17287358;17330950;19684113;19779198;19795423;19823750;20702584;21177495;23749301;24374639;30516470;32597660;33229814;33481703;33491328;7670463;9436989", "class_list": "", "function": "Functions as an activator subunit for the CBK1 protein kinase. Part of the regulation of ACE2 activity and cellular morphogenesis (RAM) signaling network. Required for coordinating polarized cell growth during interphase with the onset of mitosis. Required for mother/daughter cell separation after cytokinesis. Also has a role in the prevention of nuclear export of ACE2 from the daughter cell nucleus after mitotic exit. It coordinates ACE2-dependent transcription with mitotic exit network activation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6VTJ5", "ec_number_list": [], "go_molecular_function": "GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005933 cellular bud;GO:0005934 cellular bud tip;GO:0005935 cellular bud neck", "go_biological_process": "GO:0000920 septum digestion after cytokinesis;GO:0001934 positive regulation of protein phosphorylation;GO:0007165 signal transduction;GO:0051301 cell division;GO:0007163 establishment or maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P43563-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43564-1", "uniprot_id": [ { "id": "MIL1_YEAST", "url": "https://www.uniprot.org/uniprot/P43564", "type": "external" } ], "mass": 119510.0, "length": 1073, "protein_name": "Probable lipase MIL1", "gene_name": "MIL1", "organism": "Yeast", "refseq_name": "Mil1p", "refseq_ac": [ { "id": "NP_116583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116583", "type": "external" } ], "gene_names_uniprotkb": "MIL1", "gene_names_refseq": "MIL1", "protein_names_uniprotkb": "Probable lipase MIL1; 3.1.1.-; Medium adaptin-interacting ligand 1", "protein_names_refseq": "Mil1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YFL034W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562106;15286401;16847258;17330950;18407956;19779198;19795423;19823750;22218487;23749301;24374639;26658609;32597660;33481703;33491328;34965436;7670463", "class_list": "", "function": "Probable lipase that recruits the AP-1-related (AP-1R) complex to membranes via interaction with APM2 (PubMed:26658609). The AP-1R complex is an adapter protein complex that mediates of cargo protein SNC1 sorting in clathrin-coated vesicles (PubMed:26658609)., [UniProtKB, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "D6VTJ7", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0035650 AP-1 adaptor complex binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane;GO:0031901 early endosome membrane;GO:0030665 clathrin-coated vesicle membrane", "go_biological_process": "GO:0035652 clathrin-coated vesicle cargo loading", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P43564-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43567-1", "uniprot_id": [ { "id": "AGX1_YEAST", "url": "https://www.uniprot.org/uniprot/P43567", "type": "external" } ], "mass": 41907.0, "length": 385, "protein_name": "Alanine--glyoxylate aminotransferase 1", "gene_name": "AGX1", "organism": "Yeast", "refseq_name": "alanine--glyoxylate transaminase", "refseq_ac": [ { "id": "NP_116623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116623", "type": "external" } ], "gene_names_uniprotkb": "AGX1", "gene_names_refseq": "AGX1", "protein_names_uniprotkb": "Alanine--glyoxylate aminotransferase 1; 2.6.1.44", "protein_names_refseq": "alanine--glyoxylate transaminase", "tax_id": 559292, "disease": "primary hyperoxaluria type 1 (Disease Ontology:DOID:0111670); primary hyperoxaluria (Disease Ontology:DOID:2977)", "pathway": " (sce:YFL030W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;14745783;16226833;24374639;33491328;3933486;7670463", "class_list": "", "function": "Has alanine:glyoxylate aminotransferase activity., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VTK0", "ec_number_list": [ { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" } ], "go_molecular_function": "GO:0004760 L-serine-pyruvate transaminase activity;GO:0008453 alanine-glyoxylate transaminase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0019265 glycine biosynthetic process, by transamination of glyoxylate", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P43567-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43571-1", "uniprot_id": [ { "id": "BST1_YEAST", "url": "https://www.uniprot.org/uniprot/P43571", "type": "external" } ], "mass": 117755.0, "length": 1029, "protein_name": "GPI inositol-deacylase", "gene_name": "BST1", "organism": "Yeast", "refseq_name": "Bst1p", "refseq_ac": [ { "id": "NP_116628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116628", "type": "external" } ], "gene_names_uniprotkb": "BST1", "gene_names_refseq": "BST1; PER17", "protein_names_uniprotkb": "GPI inositol-deacylase; 3.1.-.-; Bypass of SEC30 protein 1", "protein_names_refseq": "Bst1p", "tax_id": 559292, "disease": "holoprosencephaly (Disease Ontology:DOID:4621)", "pathway": " (sce:YFL025C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11673477;14562095;14734546;16319176;23749301;24374639;33491328;7670463;8862519", "class_list": "", "function": "Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins. Required for the transport of misfolded protein to the Golgi, although dipensable for the transport of many normal proteins., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "D6VTK5", "ec_number_list": [], "go_molecular_function": "GO:0050185 phosphatidylinositol deacylase activity;GO:0160215 deacylase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0016050 vesicle organization;GO:0036503 ERAD pathway;GO:0006621 protein retention in ER lumen", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P43571-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43572-1", "uniprot_id": [ { "id": "EPL1_YEAST", "url": "https://www.uniprot.org/uniprot/P43572", "type": "external" } ], "mass": 96738.0, "length": 832, "protein_name": "Enhancer of polycomb-like protein 1", "gene_name": "EPL1", "organism": "Yeast", "refseq_name": "Epl1p", "refseq_ac": [ { "id": "NP_116629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116629", "type": "external" } ], "gene_names_uniprotkb": "EPL1", "gene_names_refseq": "EPL1", "protein_names_uniprotkb": "Enhancer of polycomb-like protein 1", "protein_names_refseq": "Epl1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YFL024C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10911987;12782659;14562095;14562106;14690591;14966276;15045029;15353583;15485911;17563356;24374639;33481703;33491328;7670463;9735366", "class_list": "", "function": "Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VTK6", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035267 NuA4 histone acetyltransferase complex;GO:0032777 piccolo histone acetyltransferase complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P43572-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43593-1", "uniprot_id": [ { "id": "UBP6_YEAST", "url": "https://www.uniprot.org/uniprot/P43593", "type": "external" } ], "mass": 57111.0, "length": 499, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 6", "gene_name": "UBP6", "organism": "Yeast", "refseq_name": "ubiquitin-specific protease UBP6", "refseq_ac": [ { "id": "NP_116665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116665", "type": "external" } ], "gene_names_uniprotkb": "UBP6", "gene_names_refseq": "UBP6", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 6; 3.4.19.12; Deubiquitinating enzyme 6; Ubiquitin thioesterase 6; Ubiquitin-specific-processing protease 6", "protein_names_refseq": "ubiquitin-specific protease UBP6", "tax_id": 559292, "disease": "prion disease (Disease Ontology:DOID:649)", "pathway": " (sce:YFR010W); (R-SCE-5689880)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10386876;10527495;11029046;12408819;14562106;14581483;17018280;17190603;17330950;17563356;18407956;19779198;21126336;22814378;23749301;24374639;30516470;32597660;33481703;33491328;7670463;9344467", "class_list": "", "function": "Predominant proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Has proteasome-inhibitory activity and delays the degradation of ubiquitinated proteins to provide a time window allowing gradual deubiquitination of the substrate. Stabilizes the association of HUL5 with proteasomes and works in opposition to polyubiquitin elongation activity of HUL5., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTP0", "ec_number_list": [ { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0070628 proteasome binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0000502 proteasome complex;GO:0005838 proteasome regulatory particle", "go_biological_process": "GO:0016579 protein deubiquitination;GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process;GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1901799 negative regulation of proteasomal protein catabolic process;GO:1904293 negative regulation of ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P43593-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43601-1", "uniprot_id": [ { "id": "ATG18_YEAST", "url": "https://www.uniprot.org/uniprot/P43601", "type": "external" } ], "mass": 55102.0, "length": 500, "protein_name": "Autophagy-related protein 18", "gene_name": "ATG18", "organism": "Yeast", "refseq_name": "phosphoinositide binding protein ATG18", "refseq_ac": [ { "id": "NP_444297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444297", "type": "external" } ], "gene_names_uniprotkb": "ATG18; AUT10; CVT18; NMR1; SVP1", "gene_names_refseq": "ATG18; AUT10; CVT18; NMR1; SVP1", "protein_names_uniprotkb": "Autophagy-related protein 18; Cytoplasm to vacuole targeting protein 18; Needed for premeiotic replication protein 1; Swollen vacuole phenotype protein 1", "protein_names_refseq": "phosphoinositide binding protein ATG18", "tax_id": 559292, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (sce:YFR021W); (R-SCE-1632852)", "pathway_count": 2, "publication_count": 36, "publication_id_list": "11470404;11536337;11707261;11739783;14536056;14562106;14723849;15103325;15155809;15194695;16876790;17699591;18407956;18497569;18586673;18769150;18829864;19037259;20154084;21126336;21536737;22108003;22333915;22704557;22728243;22753491;22787281;22889849;23749301;24374639;24440502;24905091;32809042;33481703;33491328;7670463", "class_list": "", "function": "Phosphoinositide binding protein that plays a key role in cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy (PubMed:11470404, PubMed:11536337, PubMed:11707261, PubMed:11739783, PubMed:15155809, PubMed:15194695, PubMed:16876790, PubMed:18769150, PubMed:20154084). Component of the PI(3,5)P2 regulatory complex that regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:18586673, PubMed:19037259). Involved in correct ATG9 trafficking to the pre-autophagosomal structure (PubMed:14723849, PubMed:18829864, PubMed:24905091). With ATG2, protects ATG8 from ATG4-mediated cleavage (PubMed:22108003, PubMed:22728243). May negatively regulate FAB1 activity by sequestering or masking VAC7 from FAB1 (PubMed:17699591). Plays an important role in osmotically-induced vacuole fragmentation (PubMed:22787281)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTQ1", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0010008 endosome membrane;GO:0071944 cell periphery;GO:0005774 vacuolar membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0016236 macroautophagy;GO:0034497 protein localization to phagophore assembly site;GO:0044090 positive regulation of vacuole organization;GO:0000422 autophagy of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P43601-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43602-1", "uniprot_id": [ { "id": "ROG3_YEAST", "url": "https://www.uniprot.org/uniprot/P43602", "type": "external" } ], "mass": 79709.0, "length": 733, "protein_name": "Protein ROG3", "gene_name": "ROG3", "organism": "Yeast", "refseq_name": "Rog3p", "refseq_ac": [ { "id": "NP_116677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116677", "type": "external" } ], "gene_names_uniprotkb": "ROG3", "gene_names_refseq": "ART7; ROG3", "protein_names_uniprotkb": "Protein ROG3; Revertant of glycogen synthase kinase mutation protein 3", "protein_names_refseq": "Rog3p", "tax_id": 559292, "disease": "stomach cancer (Disease Ontology:DOID:10534); Reye syndrome (Disease Ontology:DOID:14525); glaucoma (Disease Ontology:DOID:1686); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YFR022W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12163175;18407956;19779198;21126336;23749301;24374639;32597660;33481703;33491328;7670463", "class_list": "", "function": "Involved in resistance to GST substrate o-dinitrobenzene (o-DNB)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 28, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTQ2", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0002092 positive regulation of receptor internalization;GO:0070086 ubiquitin-dependent endocytosis;GO:0071444 cellular response to pheromone;GO:0000747 conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P43602-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43616-1", "uniprot_id": [ { "id": "DUG1_YEAST", "url": "https://www.uniprot.org/uniprot/P43616", "type": "external" } ], "mass": 52871.0, "length": 481, "protein_name": "Cys-Gly metallodipeptidase DUG1", "gene_name": "DUG1", "organism": "Yeast", "refseq_name": "metallodipeptidase", "refseq_ac": [ { "id": "NP_116702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116702", "type": "external" } ], "gene_names_uniprotkb": "DUG1", "gene_names_refseq": "DUG1", "protein_names_uniprotkb": "Cys-Gly metallodipeptidase DUG1; 3.4.13.-; Deficient in utilization of glutathione protein 1; GSH degradosomal complex subunit DUG1", "protein_names_refseq": "metallodipeptidase", "tax_id": 559292, "disease": "glomerulonephritis (Disease Ontology:DOID:2921)", "pathway": " (sce:YFR044C); (R-SCE-174403); (R-SCE-9753281)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "14562095;14562106;16823961;17179087;17322287;18407956;19346245;21126336;23749301;24374639;32597660;33481703;33491328;7670463;8686379;8962070", "class_list": "", "function": "Catalytic component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. Also functions in a DUG2-DUG3-independent manner as a dipeptidase with high specificity for Cys-Gly and no activity toward tri- or tetrapeptides., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTS7", "ec_number_list": [ { "id": "3.4.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.-", "type": "external" } ], "go_molecular_function": "GO:0008242 omega peptidase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0070573 metallodipeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006751 glutathione catabolic process;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P43616-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43633-1", "uniprot_id": [ { "id": "ALK1_YEAST", "url": "https://www.uniprot.org/uniprot/P43633", "type": "external" } ], "mass": 86087.0, "length": 760, "protein_name": "Serine/threonine-protein kinase Haspin homolog ALK1", "gene_name": "ALK1", "organism": "Yeast", "refseq_name": "protein kinase ALK1", "refseq_ac": [ { "id": "NP_011494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011494", "type": "external" } ], "gene_names_uniprotkb": "ALK1; G3686", "gene_names_refseq": "ALK1", "protein_names_uniprotkb": "Serine/threonine-protein kinase Haspin homolog ALK1; 2.7.11.1; DNA damage-responsive protein ALK1", "protein_names_refseq": "protein kinase ALK1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL021W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562106;16855400;17287358;18407956;19684113;19779198;19795423;19823750;23749301;24374639;30516470;32597660;33481703;33491328;9169869", "class_list": "", "function": "Serine/threonine haspin-like protein kinase involved in cell cycle regulation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 54, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUB6", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0072354 histone H3T3 kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0035556 intracellular signal transduction;GO:0006974 DNA damage response;GO:0044879 mitotic morphogenesis checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P43633-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43635-1", "uniprot_id": [ { "id": "CISY3_YEAST", "url": "https://www.uniprot.org/uniprot/P43635", "type": "external" } ], "mass": 53811.0, "length": 486, "protein_name": "Citrate synthase 3, mitochondrial", "gene_name": "CIT3", "organism": "Yeast", "refseq_name": "citrate (Si)-synthase CIT3", "refseq_ac": [ { "id": "NP_015325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015325", "type": "external" } ], "gene_names_uniprotkb": "CIT3; YP9723.01", "gene_names_refseq": "CIT3", "protein_names_uniprotkb": "Citrate synthase 3, mitochondrial; 2.3.3.1", "protein_names_refseq": "citrate (Si)-synthase CIT3", "tax_id": 559292, "disease": "limb ischemia (Disease Ontology:DOID:0050852); left ventricular failure (Disease Ontology:DOID:0051064); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); hypothyroidism (Disease Ontology:DOID:1459); bipolar disorder (Disease Ontology:DOID:3312); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hyperthyroidism (Disease Ontology:DOID:7998)", "pathway": " (sce:YPR001W)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17570335;24374639;9140965;9169875", "class_list": "", "function": "Dual specificity mitochondrial citrate and methylcitrate synthase with similar catalytic efficiency with both acetyl-CoA and propionyl-CoA., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W412", "ec_number_list": [ { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.16", "type": "external" } ], "go_molecular_function": "GO:0036440 citrate synthase activity;GO:0050440 2-methylcitrate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0005975 carbohydrate metabolic process;GO:0019629 propionate catabolic process, 2-methylcitrate cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P43635-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43682-1", "uniprot_id": [ { "id": "SFT1_YEAST", "url": "https://www.uniprot.org/uniprot/P43682", "type": "external" } ], "mass": 10961.0, "length": 97, "protein_name": "Protein transport protein SFT1", "gene_name": "SFT1", "organism": "Yeast", "refseq_name": "Sft1p", "refseq_ac": [ { "id": "NP_012919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012919", "type": "external" } ], "gene_names_uniprotkb": "SFT1; YKL006BC", "gene_names_refseq": "SFT1", "protein_names_uniprotkb": "Protein transport protein SFT1; P14", "protein_names_refseq": "Sft1p", "tax_id": 559292, "disease": "uterine fibroid (Disease Ontology:DOID:13223); endometrial adenocarcinoma (Disease Ontology:DOID:2870)", "pathway": " (sce:YKL006C-A); (R-SCE-6807878); (R-SCE-6811438)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11001058;15229219;23749301;24374639;33491328;7596416;8196765;8488728", "class_list": "", "function": "Vesicle SNARE required for retrograde transport within the Golgi complex., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXT0", "ec_number_list": [], "go_molecular_function": "GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:1990674 Golgi cis cisterna membrane;GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031201 SNARE complex;GO:0000138 Golgi trans cisterna", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006906 vesicle fusion;GO:0048280 vesicle fusion with Golgi apparatus;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P43682-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P45818-1", "uniprot_id": [ { "id": "ROK1_YEAST", "url": "https://www.uniprot.org/uniprot/P45818", "type": "external" } ], "mass": 63653.0, "length": 564, "protein_name": "ATP-dependent RNA helicase ROK1", "gene_name": "ROK1", "organism": "Yeast", "refseq_name": "RNA-dependent ATPase ROK1", "refseq_ac": [ { "id": "NP_011344", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011344", "type": "external" } ], "gene_names_uniprotkb": "ROK1; G1651", "gene_names_refseq": "ROK1", "protein_names_uniprotkb": "ATP-dependent RNA helicase ROK1; 3.6.4.13; Rescuer of KEM1 protein 1", "protein_names_refseq": "RNA-dependent ATPase ROK1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL171W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10373593;12054531;12628929;15013450;15358132;15523097;23749301;24374639;32597660;33481703;33491328;8529880;8896267;9154839;9169869;9848659", "class_list": "", "function": "ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. May also have a gene-specific regulatory function since it affects nuclear fusion by regulating KAR4 expression and contributes with KEM1 to ISP-1 sensitivity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VTY1", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.1.1.260", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.260", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0008186 ATP-dependent activity, acting on RNA", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030686 90S preribosome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0048254 snoRNA localization;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P45818-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P45978-1", "uniprot_id": [ { "id": "SCD6_YEAST", "url": "https://www.uniprot.org/uniprot/P45978", "type": "external" } ], "mass": 39190.0, "length": 349, "protein_name": "Protein SCD6", "gene_name": "SCD6", "organism": "Yeast", "refseq_name": "Scd6p", "refseq_ac": [ { "id": "NP_015454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015454", "type": "external" } ], "gene_names_uniprotkb": "SCD6; P9659.10", "gene_names_refseq": "LSM13; SCD6", "protein_names_uniprotkb": "Protein SCD6; Suppressor of clathrin deficiency protein 6", "protein_names_refseq": "Scd6p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR129W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562106;17322287;22284680;22814378;23749301;24374639;27613419;32597660;33481703;33491328;33566094;33856219;9169875", "class_list": "", "function": "Involved in regulation of translation and mRNA degradation. Represses translation by binding the eIF4G subunit (TIF4631 or TIF4632) of the eIF4F complex dependent on its RGG domain, forming an mRNP repressed for translation initiation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4C6", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0031370 eukaryotic initiation factor 4G binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0045947 negative regulation of translational initiation;GO:0033962 P-body assembly;GO:0034063 stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P45978-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46367-1", "uniprot_id": [ { "id": "ALDH4_YEAST", "url": "https://www.uniprot.org/uniprot/P46367", "type": "external" } ], "mass": 56724.0, "length": 519, "protein_name": "Potassium-activated aldehyde dehydrogenase, mitochondrial", "gene_name": "ALD4", "organism": "Yeast", "refseq_name": "aldehyde dehydrogenase (NADP(+)) ALD4", "refseq_ac": [ { "id": "NP_015019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015019", "type": "external" } ], "gene_names_uniprotkb": "ALD4; ALD7; ALDH2; O6730", "gene_names_refseq": "ALD4; ALD7", "protein_names_uniprotkb": "Potassium-activated aldehyde dehydrogenase, mitochondrial; 1.2.1.5; K(+)-ACDH; K(+)-activated acetaldehyde dehydrogenase", "protein_names_refseq": "aldehyde dehydrogenase (NADP(+)) ALD4", "tax_id": 559292, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); isolated microphthalmia 8 (Disease Ontology:DOID:0060841); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); DiGeorge syndrome (Disease Ontology:DOID:11198); heart disease (Disease Ontology:DOID:114); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); alcohol use disorder (Disease Ontology:DOID:1574); pancreatic cancer (Disease Ontology:DOID:1793); brain infarction (Disease Ontology:DOID:3454); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); liver disease (Disease Ontology:DOID:409); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (sce:YOR374W); (R-SCE-380612); (R-SCE-5365859); (R-SCE-70350); (R-SCE-71384); (R-SCE-9837999)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "11502169;14562106;15256563;17761666;19779198;1989592;21177495;24374639;33491328;9150920;9169874;9473035;9675847", "class_list": "", "function": "Potassium-activated aldehyde dehydrogenase involved in acetate formation during anaerobic growth on glucose., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W367;Q08898", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.4", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "1.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.64", "type": "external" } ], "go_molecular_function": "GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity;GO:0140088 acetaldehyde dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0019413 acetate biosynthetic process;GO:0006740 NADPH regeneration;GO:0006067 ethanol metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P46367-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46654-1", "uniprot_id": [ { "id": "RSSA2_YEAST", "url": "https://www.uniprot.org/uniprot/P46654", "type": "external" } ], "mass": 27962.0, "length": 252, "protein_name": "Small ribosomal subunit protein uS2B", "gene_name": "RPS0B", "organism": "Yeast", "refseq_name": "40S ribosomal protein uS2 RPS0B", "refseq_ac": [ { "id": "NP_013149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013149", "type": "external" } ], "gene_names_uniprotkb": "RPS0B; L2118; NAB1B; NAB4; YST2", "gene_names_refseq": "NAB1B; RPS0B; YST2", "protein_names_uniprotkb": "Small ribosomal subunit protein uS2B; 40S ribosomal protein S0-B; Nucleic acid-binding protein NAB1B", "protein_names_refseq": "40S ribosomal protein uS2 RPS0B", "tax_id": 559292, "disease": "arrhythmogenic right ventricular dysplasia 5 (Disease Ontology:DOID:0110074); sciatic neuropathy (Disease Ontology:DOID:11446); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (sce:YLR048W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10601260;14562095;14562106;14627813;15665377;21126336;22096102;24374639;24524803;30516470;33491328;8626693;9038161;9169871;9559554;9718729;9973221", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uS2 is required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits (PubMed:14627813, PubMed:9973221)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY50", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0000054 ribosomal subunit export from nucleus;GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0002181 cytoplasmic translation;GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P46654-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46655-1", "uniprot_id": [ { "id": "SYEC_YEAST", "url": "https://www.uniprot.org/uniprot/P46655", "type": "external" } ], "mass": 80843.0, "length": 708, "protein_name": "Glutamate--tRNA ligase, cytoplasmic", "gene_name": "GUS1", "organism": "Yeast", "refseq_name": "glutamate--tRNA ligase GUS1", "refseq_ac": [ { "id": "NP_011269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011269", "type": "external" } ], "gene_names_uniprotkb": "GUS1; G0583; HRB724", "gene_names_refseq": "GSN1; GUS1", "protein_names_uniprotkb": "Glutamate--tRNA ligase, cytoplasmic; (c)ERS; 6.1.1.17; GluRS; Glutamyl-tRNA synthetase; P85", "protein_names_refseq": "glutamate--tRNA ligase GUS1", "tax_id": 559292, "disease": "hypomyelinating leukodystrophy 15 (Disease Ontology:DOID:0070398)", "pathway": " (sce:YGL245W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11069915;11726524;12748633;14562095;14562106;16914447;17139087;18407956;19417106;21126336;22814378;23749301;24374639;33481703;33491328;8750240;8895587;8972578;9169869;9659920", "class_list": "", "function": "Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). In mitochondria, constitutes the nondiscriminating glutamyl-tRNA synthase that generates the mitochondrial mischarged glutamyl-tRNA(Gln) substrate for the tRNA-dependent amidotransferase (AdT), which generates mitochondrial glutaminyl-tRNA(Gln) by transamidation of glutamyl-tRNA(Gln)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV90", "ec_number_list": [ { "id": "6.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.17", "type": "external" } ], "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0004818 glutamate-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0017102 methionyl glutamyl tRNA synthetase complex;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006424 glutamyl-tRNA aminoacylation;GO:0006431 methionyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P46655-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46669-1", "uniprot_id": [ { "id": "RPA43_YEAST", "url": "https://www.uniprot.org/uniprot/P46669", "type": "external" } ], "mass": 36224.0, "length": 326, "protein_name": "DNA-directed RNA polymerase I subunit RPA43", "gene_name": "RPA43", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase I subunit RPA43", "refseq_ac": [ { "id": "NP_014985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014985", "type": "external" } ], "gene_names_uniprotkb": "RPA43; O6271; RRN12", "gene_names_refseq": "RPA43", "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit RPA43; A43; DNA-directed DNA-dependent RNA polymerase 36 kDa polypeptide", "protein_names_refseq": "DNA-directed RNA polymerase I subunit RPA43", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR340C); (R-SCE-73762); (R-SCE-73772)", "pathway_count": 3, "publication_count": 28, "publication_id_list": "11032814;11717393;12145213;12407181;12888498;14562095;14562106;15665377;17330950;18084032;18160037;18407956;19779198;19795423;19823750;20702584;21126336;22218487;23749301;24153182;24153184;24374639;32597660;33481703;33491328;7592632;8948102;9169874", "class_list": "", "function": "DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. Through its association with RRN3 is involved in recruitment of Pol I to rDNA promoters. In vitro, the A13-A43 subcomplex binds single-stranded RNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W335;Q99187", "ec_number_list": [], "go_molecular_function": "GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005736 RNA polymerase I complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042254 ribosome biogenesis;GO:0006362 transcription elongation by RNA polymerase I;GO:0006361 transcription initiation at RNA polymerase I promoter;GO:0006363 termination of RNA polymerase I transcription", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P46669-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46675-1", "uniprot_id": [ { "id": "STU2_YEAST", "url": "https://www.uniprot.org/uniprot/P46675", "type": "external" } ], "mass": 100918.0, "length": 888, "protein_name": "Protein STU2", "gene_name": "STU2", "organism": "Yeast", "refseq_name": "Stu2p", "refseq_ac": [ { "id": "NP_013146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013146", "type": "external" } ], "gene_names_uniprotkb": "STU2; L2108", "gene_names_refseq": "STU2", "protein_names_uniprotkb": "Protein STU2; Suppressor of tubulin 2", "protein_names_refseq": "Stu2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR045C)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "11309422;14562106;16567500;17287358;17330950;17355870;17563356;17889670;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22031224;22904013;23749301;24374639;25097237;25172511;27156448;32597660;33229814;33481703;33491328;9169871;9382872;9606209", "class_list": "", "function": "Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. May play a role in the attachment, organization, and/or dynamics of microtubule ends at the spindle pole body. Stabilizes both cytoplasmic and nuclear microtubules. Promotes mitotic spindle elongation in anaphase. Has microtubule polymerase activity by accelerating microtubule growth and inhibiting catastrophe. The polymerase activity is proposed to involve a tethering mechanism at the microtubule plus end: a curved, longitudinally microtubule lattice-associated tubulin heterodimer (that cannot be incorporated into the microtubule lattice) is bound via one TOG domain while the other TOG domain binds to an unpolymerized tubulin heterodimer leading to lateral association of these tubulin heterodimers; polymerization-induced straightening of the tubulin heterodimer releases the polymerase (PubMed:11309422, PubMed:16567500, PubMed:25097237, PubMed:25172511). Is involved in regulation of kinetochore-microtubule attachments in a tension-dependent manner involving its association with the NDC80 complex; the function may be independent of its microtubule polymerase activity. Can either stabilize or destabilize kinetochore attachments, depending on the level of kinetochore tension and whether the microtubule tip is assembling or disassembling (PubMed:27156448)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VY47", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0051010 microtubule plus-end binding;GO:0061863 microtubule plus end polymerase", "go_cellular_component": "GO:0000922 spindle pole;GO:0005938 cell cortex;GO:0000776 kinetochore;GO:0005876 spindle microtubule;GO:0005816 spindle pole body", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0099606 microtubule plus-end directed mitotic chromosome migration;GO:0007020 microtubule nucleation;GO:0007052 mitotic spindle organization;GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P46675-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46678-1", "uniprot_id": [ { "id": "TFC5_YEAST", "url": "https://www.uniprot.org/uniprot/P46678", "type": "external" } ], "mass": 67688.0, "length": 594, "protein_name": "Transcription factor TFIIIB component B''", "gene_name": "BDP1", "organism": "Yeast", "refseq_name": "transcription factor TFIIIB subunit BDP1", "refseq_ac": [ { "id": "NP_014359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014359", "type": "external" } ], "gene_names_uniprotkb": "BDP1; N2682; TFC5", "gene_names_refseq": "BDP1; TFC5; TFC7", "protein_names_uniprotkb": "Transcription factor TFIIIB component B''; TFIIIB90", "protein_names_refseq": "transcription factor TFIIIB subunit BDP1", "tax_id": 559292, "disease": "autosomal recessive nonsyndromic deafness 112 (Disease Ontology:DOID:0111637)", "pathway": " (sce:YNL039W); (R-SCE-76061); (R-SCE-76066)", "pathway_count": 3, "publication_count": 26, "publication_id_list": "12930823;15665377;17330950;17563356;18407956;1922038;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;25970584;30516470;32597660;33481703;33491328;33502312;7568218;8617241;8662956;9169873", "class_list": "", "function": "General activator of RNA polymerase III transcription., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1E0", "ec_number_list": [], "go_molecular_function": "GO:0001156 TFIIIC-class transcription factor complex binding;GO:0000995 RNA polymerase III general transcription initiation factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000126 transcription factor TFIIIB complex", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0070898 RNA polymerase III preinitiation complex assembly;GO:0006359 regulation of transcription by RNA polymerase III;GO:0001112 DNA-templated transcription open complex formation", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P46678-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46680-1", "uniprot_id": [ { "id": "AIP1_YEAST", "url": "https://www.uniprot.org/uniprot/P46680", "type": "external" } ], "mass": 67326.0, "length": 615, "protein_name": "Actin-interacting protein 1", "gene_name": "AIP1", "organism": "Yeast", "refseq_name": "Aip1p", "refseq_ac": [ { "id": "NP_013810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013810", "type": "external" } ], "gene_names_uniprotkb": "AIP1; YM9582.17C", "gene_names_refseq": "AIP1", "protein_names_uniprotkb": "Actin-interacting protein 1", "protein_names_refseq": "Aip1p", "tax_id": 559292, "disease": "hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)", "pathway": " (sce:YMR092C); (R-SCE-114608)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10366597;12807914;14562106;18407956;22814378;24374639;33491328;9169872", "class_list": "", "function": "Involved in the depolymerization of actin filaments. Enhances the filament disassembly activity of cofilin and restricts cofilin localization to cortical actin patches., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZR5", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0030864 cortical actin cytoskeleton;GO:0030479 actin cortical patch", "go_biological_process": "GO:0051016 barbed-end actin filament capping;GO:0032466 negative regulation of cytokinesis;GO:0030042 actin filament depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P46680-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46681-1", "uniprot_id": [ { "id": "DLD2_YEAST", "url": "https://www.uniprot.org/uniprot/P46681", "type": "external" } ], "mass": 59268.0, "length": 530, "protein_name": "D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2", "gene_name": "DLD2", "organism": "Yeast", "refseq_name": "D-lactate dehydrogenase", "refseq_ac": [ { "id": "NP_010103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010103", "type": "external" } ], "gene_names_uniprotkb": "DLD2; AIP2", "gene_names_refseq": "AIP2; DLD2", "protein_names_uniprotkb": "D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2; 1.1.2.4; 1.1.99.40; Actin-interacting protein 2; D-2HG--pyruvate transhydrogenase DLD2; D-LCR; D-lactate dehydrogenase [cytochrome] 2, mitochondrial; D-lactate ferricytochrome C oxidoreductase", "protein_names_refseq": "D-lactate dehydrogenase", "tax_id": 559292, "disease": "D-2-hydroxyglutaric aciduria 1 (Disease Ontology:DOID:0111351); cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YDL178W); (R-SCE-880009)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10509019;14562106;15158445;17322287;24374639;26774271;33491328;9169867", "class_list": "", "function": "Catalyzes the reversible oxidation of (R)-2-hydroxyglutarate to 2-oxoglutarate coupled to reduction of pyruvate to (R)-lactate. Can also use oxaloacetate as electron acceptor instead of pyruvate producing (R)-malate (PubMed:26774271). In addition to its enzymatic role it could play an important role in the yeast cell morphology (PubMed:10509019)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRH4;Q66RH8", "ec_number_list": [ { "id": "1.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.2.4", "type": "external" }, { "id": "1.1.99.40", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.99.40", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0071949 FAD binding;GO:0004458 D-lactate dehydrogenase (cytochrome) activity;GO:0051990 (R)-2-hydroxyglutarate dehydrogenase activity;GO:0099615 (R)-2-hydroxyglutarate-pyruvate transhydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:1903457 lactate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P46681-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46682-1", "uniprot_id": [ { "id": "AP3B_YEAST", "url": "https://www.uniprot.org/uniprot/P46682", "type": "external" } ], "mass": 91607.0, "length": 809, "protein_name": "AP-3 complex subunit beta", "gene_name": "APL6", "organism": "Yeast", "refseq_name": "AP-3 complex subunit beta", "refseq_ac": [ { "id": "NP_011777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011777", "type": "external" } ], "gene_names_uniprotkb": "APL6; G9331; YKS5", "gene_names_refseq": "APL6; YKS5", "protein_names_uniprotkb": "AP-3 complex subunit beta; Adaptor-related protein complex 3 subunit beta; Beta-3-adaptin; Clathrin assembly protein complex 3 beta large chain; Clathrin assembly protein large beta chain", "protein_names_refseq": "AP-3 complex subunit beta", "tax_id": 559292, "disease": "Hermansky-Pudlak syndrome 2 (Disease Ontology:DOID:0060540); developmental and epileptic encephalopathy 48 (Disease Ontology:DOID:0080448); neutropenia (Disease Ontology:DOID:1227); platelet storage pool deficiency (Disease Ontology:DOID:2223); interstitial lung disease (Disease Ontology:DOID:3082); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753); pulmonary fibrosis (Disease Ontology:DOID:3770)", "pathway": " (sce:YGR261C)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10559961;14562095;14562106;17330950;17873058;18407956;19779198;19795423;19823750;20702584;21126336;22218487;23749301;24374639;24909858;32597660;33229814;33481703;33491328;9090059;9169869;9250663;9335339", "class_list": "", "function": "Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. Required for the transport via the ALP pathway, which directs the transport of the cargo proteins PHO8 and VAM3 to the vacuole., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VV40", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030665 clathrin-coated vesicle membrane;GO:0030123 AP-3 adaptor complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0006623 protein targeting to vacuole;GO:0006896 Golgi to vacuole transport", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P46682-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46943-1", "uniprot_id": [ { "id": "GUF1_YEAST", "url": "https://www.uniprot.org/uniprot/P46943", "type": "external" } ], "mass": 73188.0, "length": 645, "protein_name": "Translation factor GUF1, mitochondrial", "gene_name": "GUF1", "organism": "Yeast", "refseq_name": "GTPase GUF1", "refseq_ac": [ { "id": "NP_013392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013392", "type": "external" } ], "gene_names_uniprotkb": "GUF1; L8003.7", "gene_names_refseq": "GUF1", "protein_names_uniprotkb": "Translation factor GUF1, mitochondrial; 3.6.5.-; EF-4; Elongation factor 4 homolog; GTPase GUF1; Ribosomal back-translocase", "protein_names_refseq": "GTPase GUF1", "tax_id": 559292, "disease": "West syndrome (Disease Ontology:DOID:0050562); developmental and epileptic encephalopathy 40 (Disease Ontology:DOID:0080427)", "pathway": " (sce:YLR289W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562095;14562106;16415861;18442968;24374639;8553703;9169871", "class_list": "", "function": "Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYT5;Q05891", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0097177 mitochondrial ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006412 translation;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P46943-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46944-1", "uniprot_id": [ { "id": "TRS85_YEAST", "url": "https://www.uniprot.org/uniprot/P46944", "type": "external" } ], "mass": 80495.0, "length": 698, "protein_name": "Trafficking protein particle complex III-specific subunit 85", "gene_name": "TRS85", "organism": "Yeast", "refseq_name": "Trs85p", "refseq_ac": [ { "id": "NP_010393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010393", "type": "external" } ], "gene_names_uniprotkb": "TRS85; GSG1; MUM1; YD9727.04", "gene_names_refseq": "GSG1; MUM1; TRS85", "protein_names_uniprotkb": "Trafficking protein particle complex III-specific subunit 85; Muddled meiosis protein 1; Sporulation protein GSG1; TRAPP III-specific subunit 85; Transport protein particle 85 kDa subunit", "protein_names_refseq": "Trs85p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR108W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10727015;11239471;14562106;16079147;16874038;18407956;19684113;19779198;19795423;19823750;20375281;21126336;21177495;23749301;24374639;32597660;33229814;33481703;33491328;8619313;9169867;9564032", "class_list": "", "function": "Specific subunit of the TRAPP III complex that acts as an autophagy-specific guanine nucleotide exchange factor (GEF) for YPT1. TRS85 directs the TRAPP III complex to the phagophore assembly site (PAS) that is involved in autophagosome formation. Required for membrane expansion during autophagy and the CVT pathway. Required for sporulation. Has a role late in meiosis following DNA replication., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VS94;Q04563", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0000407 phagophore assembly site;GO:1990072 TRAPPIII protein complex", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0016236 macroautophagy;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0034497 protein localization to phagophore assembly site;GO:0034727 piecemeal microautophagy of the nucleus", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P46944-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46947-1", "uniprot_id": [ { "id": "CWC26_YEAST", "url": "https://www.uniprot.org/uniprot/P46947", "type": "external" } ], "mass": 30472.0, "length": 266, "protein_name": "Pre-mRNA-splicing factor CWC26", "gene_name": "BUD13", "organism": "Yeast", "refseq_name": "Bud13p", "refseq_ac": [ { "id": "NP_011341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011341", "type": "external" } ], "gene_names_uniprotkb": "BUD13; CWC26; G1642; SLC7", "gene_names_refseq": "BUD13; CWC26", "protein_names_uniprotkb": "Pre-mRNA-splicing factor CWC26; Bud site selection protein 13; Complexed with CEF1 protein 26; Synthetic lethal with CLF1 protein 7", "protein_names_refseq": "Bud13p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL174W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "11452010;11884590;12871902;14562095;15565172;16618970;17322287;23118884;23749301;24374639;25160624;25218446;26212312;27445306;27562955;29794219;33481703;33491328;8619317;8657162;9169869", "class_list": "", "function": "Required for pre-mRNA splicing and spliceosome assembly. As part of the pre-mRNA retention and splicing (RES) complex, required for efficient splicing and nuclear retention of not properly spliced pre-mRNA (PubMed:12871902, PubMed:15565172). Indirectly involved in positioning the proximal bud pole signal by regulating the splicing of the MATa1 pre-mRNA, which encodes a repressor that normally blocks expression of haploid-specific genes in diploid cells. When Mata1 protein is lacking, Axl1, a haploid-specific protein critical for the choice between axial and bipolar budding, is expressed ectopically in diploid cells and disrupts bipolar budding (PubMed:11452010, PubMed:15565172, PubMed:23118884, PubMed:8657162)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTX8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0070274 RES complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:1903241 U2-type prespliceosome assembly;GO:0051237 maintenance of RNA location", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P46947-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46962-1", "uniprot_id": [ { "id": "CTK2_YEAST", "url": "https://www.uniprot.org/uniprot/P46962", "type": "external" } ], "mass": 37905.0, "length": 323, "protein_name": "CTD kinase subunit beta", "gene_name": "CTK2", "organism": "Yeast", "refseq_name": "Ctk2p", "refseq_ac": [ { "id": "NP_012528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012528", "type": "external" } ], "gene_names_uniprotkb": "CTK2; J1390", "gene_names_refseq": "CTK2", "protein_names_uniprotkb": "CTD kinase subunit beta; CTD kinase 38 kDa subunit; CTD kinase subunit 2; CTDK-I subunit beta", "protein_names_refseq": "Ctk2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL006C); (R-SCE-674695); (R-SCE-6796648); (R-SCE-6807505); (R-SCE-9018519)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10082518;11118453;12629047;12684377;14562095;14562106;15047695;15520468;16182287;16984969;24374639;7565723;8641269;9110987", "class_list": "", "function": "Cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTDK-I phosphorylates 'Ser-5' if the CTD substrate is not phosphorylated at 'Ser-5', but will phosphorylate 'Ser-2' of a CTD substrate if 'Ser-5' is already phosphorylated. CTDK-I is also more reactive toward substrates that are prephosphorylated at 'Ser-2' or 'Ser-5' compared with an unphosphorylated CTD substrate, therefore efficiently creating doubly phosphorylated CTD repeats. Involved in RNA polymerase II transcriptional elongation, and as part of the CTDK-I complex, pre-mRNA 3'-end processing and SET2 mediated H3K36 methylation. Together with CTK3, required for CTK1 CTD kinase activation. Required for DNA damage induced transcription. Involved in the adaptation to alternative carbon sources, including galactose, glycerol and ethanol, but not raffinose. Required for the integrity of the rDNA locus., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWG9", "ec_number_list": [], "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0008024 cyclin/CDK positive transcription elongation factor complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P46962-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46963-1", "uniprot_id": [ { "id": "CTK3_YEAST", "url": "https://www.uniprot.org/uniprot/P46963", "type": "external" } ], "mass": 34809.0, "length": 296, "protein_name": "CTD kinase subunit gamma", "gene_name": "CTK3", "organism": "Yeast", "refseq_name": "Ctk3p", "refseq_ac": [ { "id": "NP_013595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013595", "type": "external" } ], "gene_names_uniprotkb": "CTK3; YM8339.07", "gene_names_refseq": "CTK3", "protein_names_uniprotkb": "CTD kinase subunit gamma; CTD kinase 32 kDa subunit; CTD kinase subunit 3; CTDK-I gamma subunit", "protein_names_refseq": "Ctk3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YML112W)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "11118453;11875433;12629047;12684377;14562095;14562106;15047695;15520468;16182287;16984969;17322287;17563356;18407956;19779198;19795423;19823750;20489023;20702584;21126336;21177495;23749301;24374639;2670564;30516470;32597660;33481703;33491328;7565723;9110987;9169872", "class_list": "", "function": "Gamma subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTDK-I phosphorylates 'Ser-5' if the CTD substrate is not phosphorylated at 'Ser-5', but will phosphorylate 'Ser-2' of a CTD substrate if 'Ser-5' is already phosphorylated. CTDK-I is also more reactive toward substrates that are prephosphorylated at 'Ser-2' or 'Ser-5' compared with an unphosphorylated CTD substrate, therefore efficiently creating doubly phosphorylated CTD repeats. Involved in RNA polymerase I transcription and RNA polymerase II transcriptional elongation, and as part of the CTDK-I complex, pre-mRNA 3'-end processing and SET2 mediated H3K36 methylation. Together with CTK2, required for CTK1 CTD kinase activation. Required for DNA damage induced transcription. Involved in the adaptation to alternative carbon sources, including galactose, glycerol and ethanol, but not raffinose. Required for the integrity of the rDNA locus., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0H2;Q6LBS6", "ec_number_list": [], "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0070692 CTDK-1 complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P46963-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46971-1", "uniprot_id": [ { "id": "PMT4_YEAST", "url": "https://www.uniprot.org/uniprot/P46971", "type": "external" } ], "mass": 87966.0, "length": 762, "protein_name": "Dolichyl-phosphate-mannose--protein mannosyltransferase 4", "gene_name": "PMT4", "organism": "Yeast", "refseq_name": "dolichyl-phosphate-mannose-protein mannosyltransferase", "refseq_ac": [ { "id": "NP_012677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012677", "type": "external" } ], "gene_names_uniprotkb": "PMT4; J2176", "gene_names_refseq": "PMT4", "protein_names_uniprotkb": "Dolichyl-phosphate-mannose--protein mannosyltransferase 4; 2.4.1.109", "protein_names_refseq": "dolichyl-phosphate-mannose-protein mannosyltransferase", "tax_id": 559292, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Walker-Warburg syndrome (Disease Ontology:DOID:0050560); muscular dystrophy-dystroglycanopathy type B1 (Disease Ontology:DOID:0050588); cardiomyopathy (Disease Ontology:DOID:0050700); autosomal recessive limb-girdle muscular dystrophy type 2K (Disease Ontology:DOID:0110297); congenital muscular dystrophy-dystroglycanopathy type A1 (Disease Ontology:DOID:0111237); muscular dystrophy-dystroglycanopathy (Disease Ontology:DOID:0112374); cleft lip (Disease Ontology:DOID:9296); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (sce:YJR143C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10366591;12551906;14562106;14673142;14742720;16847258;17213653;17470820;24374639;8585318;8641269;8918452;9184828", "class_list": "glycogene;glycosyltransferase", "function": "Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a homodimeric complex to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins. Specifically acts on secretory proteins with an ER-luminally oriented Ser/Thr-rich region flanked by a membrane anchor such as FUS1, AXL2, GAS1, KEX2, MID2, WSC1, WSC2, OPY2, PRM5, RAX2, or YNL176., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VWW2", "ec_number_list": [ { "id": "2.4.1.109", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.109", "type": "external" } ], "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0097586 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0035269 protein O-linked glycosylation via mannose;GO:1900101 regulation of endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P46971-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46972-1", "uniprot_id": [ { "id": "IMP2_YEAST", "url": "https://www.uniprot.org/uniprot/P46972", "type": "external" } ], "mass": 19930.0, "length": 177, "protein_name": "Mitochondrial inner membrane protease subunit 2", "gene_name": "IMP2", "organism": "Yeast", "refseq_name": "endopeptidase catalytic subunit", "refseq_ac": [ { "id": "NP_013749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013749", "type": "external" } ], "gene_names_uniprotkb": "IMP2; YM9973.09", "gene_names_refseq": "IMP2", "protein_names_uniprotkb": "Mitochondrial inner membrane protease subunit 2; 3.4.21.-", "protein_names_refseq": "endopeptidase catalytic subunit", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR035W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10608835;15118906;17322287;24374639;8132591;8266095;9169872", "class_list": "", "function": "Catalytic component of the mitochondrial inner membrane peptidase (IMP) complex. IMP catalyzes the removal of signal peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. The two catalytic IMP subunits seem to have non-overlapping substrate specificities. IMP2 substrates include nuclear encoded CYB2, mitochondrially encoded COX2 and cytochrome c1. Required for the stability of IMP1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZL0", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0042720 mitochondrial inner membrane peptidase complex;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006627 protein processing involved in protein targeting to mitochondrion;GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P46972-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46989-1", "uniprot_id": [ { "id": "ATG27_YEAST", "url": "https://www.uniprot.org/uniprot/P46989", "type": "external" } ], "mass": 30201.0, "length": 271, "protein_name": "Autophagy-related protein 27", "gene_name": "ATG27", "organism": "Yeast", "refseq_name": "Atg27p", "refseq_ac": [ { "id": "NP_012357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012357", "type": "external" } ], "gene_names_uniprotkb": "ATG27; ETF1; J0490", "gene_names_refseq": "ATG27; ETF1", "protein_names_uniprotkb": "Autophagy-related protein 27; Enhancer of VPS34 missorting protein 1", "protein_names_refseq": "Atg27p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL178C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12186856;12844361;14536056;14562095;14562106;17135291;17322287;17426440;22826123;23129774;24374639;8641269", "class_list": "", "function": "Effector of VPS34 phosphatidylinositol 3-phosphate kinase signaling. Regulates the cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW11;Q86ZR9", "ec_number_list": [], "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0007034 vacuolar transport;GO:0000045 autophagosome assembly;GO:0016236 macroautophagy;GO:0034497 protein localization to phagophore assembly site;GO:0016050 vesicle organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P46989-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46990-1", "uniprot_id": [ { "id": "RL17B_YEAST", "url": "https://www.uniprot.org/uniprot/P46990", "type": "external" } ], "mass": 20551.0, "length": 184, "protein_name": "Large ribosomal subunit protein uL22B", "gene_name": "RPL17B", "organism": "Yeast", "refseq_name": "60S ribosomal protein uL22 RPL17B", "refseq_ac": [ { "id": "NP_012358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012358", "type": "external" } ], "gene_names_uniprotkb": "RPL17B; J0493; RPL20B", "gene_names_refseq": "RPL17B", "protein_names_uniprotkb": "Large ribosomal subunit protein uL22B; 60S ribosomal protein L17-B; L20; YL17", "protein_names_refseq": "60S ribosomal protein uL22 RPL17B", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL177W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14562095;14562106;15665377;17287358;18407956;18782943;20702584;22096102;22106047;23749301;24374639;24524803;32597660;33481703;8641269;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW12", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0030687 preribosome, large subunit precursor;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P46990-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46995-1", "uniprot_id": [ { "id": "SET2_YEAST", "url": "https://www.uniprot.org/uniprot/P46995", "type": "external" } ], "mass": 84461.0, "length": 733, "protein_name": "Histone-lysine N-methyltransferase, H3 lysine-36 specific", "gene_name": "SET2", "organism": "Yeast", "refseq_name": "histone methyltransferase SET2", "refseq_ac": [ { "id": "NP_012367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012367", "type": "external" } ], "gene_names_uniprotkb": "SET2; EZL1; J0520; KMT3", "gene_names_refseq": "EZL1; KMT3; SET2", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase, H3 lysine-36 specific; 2.1.1.359; Lysine N-methyltransferase 3; SET domain-containing protein 2", "protein_names_refseq": "histone methyltransferase SET2", "tax_id": 559292, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); autosomal dominant intellectual developmental disorder 70 (Disease Ontology:DOID:0061043); stomach cancer (Disease Ontology:DOID:10534); cancer (Disease Ontology:DOID:162); malignant mesothelioma (Disease Ontology:DOID:1790); liver cancer (Disease Ontology:DOID:3571); lung adenocarcinoma (Disease Ontology:DOID:3910); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); malignant pleural mesothelioma (Disease Ontology:DOID:7474); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YJL168C)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "10802733;11839797;12381723;12511561;12629047;12736296;12773564;12917322;14562106;15798214;16227595;16286474;16329992;18407956;19779198;19795423;19823750;20048053;20702584;21126336;21177495;23749301;24374639;32597660;33334889;33481703;33491328;35183557;8641269", "class_list": "", "function": "Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression. The methyltransferase activity requires the recruitment to the RNA polymerase II, which is CTK1 dependent., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW19", "ec_number_list": [ { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0046975 histone H3K36 methyltransferase activity;GO:0140955 histone H3K36 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0006355 regulation of DNA-templated transcription;GO:0006353 DNA-templated transcription termination;GO:0006283 transcription-coupled nucleotide-excision repair;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P46995-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47001-1", "uniprot_id": [ { "id": "CIS3_YEAST", "url": "https://www.uniprot.org/uniprot/P47001", "type": "external" } ], "mass": 23242.0, "length": 227, "protein_name": "Cell wall mannoprotein CIS3", "gene_name": "CIS3", "organism": "Yeast", "refseq_name": "Cis3p", "refseq_ac": [ { "id": "NP_012377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012377", "type": "external" } ], "gene_names_uniprotkb": "CIS3; CCW11; CCW5; J0561; PIR4; SCW8", "gene_names_refseq": "CCW11; CCW5; CIS3; PIR4; SCW8", "protein_names_uniprotkb": "Cell wall mannoprotein CIS3; Covalently-linked cell wall protein 5/11; Protein with internal repeats 4; Soluble cell wall protein 8", "protein_names_refseq": "Cis3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL158C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10407261;10438739;10594829;12776183;12898712;14562106;15116342;15470095;15781460;16495216;17322287;17617218;18407956;19756047;19779198;24374639;8641269;9301021;9748433", "class_list": "", "function": "Component of the outer cell wall layer. Required for stability of the cell wall and for optimal growth. Required for resistance against several antifungal and cell wall-perturbing agents., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 12, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 12, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 12, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "D6VW29", "ec_number_list": [], "go_molecular_function": "GO:0005199 structural constituent of cell wall", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P47001-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47002-1", "uniprot_id": [ { "id": "SSY5_YEAST", "url": "https://www.uniprot.org/uniprot/P47002", "type": "external" } ], "mass": 77527.0, "length": 699, "protein_name": "SPS-sensor serine protease component SSY5", "gene_name": "SSY5", "organism": "Yeast", "refseq_name": "Ssy5p", "refseq_ac": [ { "id": "NP_012379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012379", "type": "external" } ], "gene_names_uniprotkb": "SSY5; APF8; J0570", "gene_names_refseq": "RAA3; SSY5", "protein_names_uniprotkb": "SPS-sensor serine protease component SSY5; Endoprotease SSY5", "protein_names_refseq": "Ssy5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL156C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11154269;11489133;12502738;15509782;15947203;16524914;16778074;19779198;24374639;31461372;33481703;33491328;8641269;9483800", "class_list": "", "function": "Protease component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2. Catalyzes the activation of these transcription factors, which are synthesized as latent cytoplasmic precursors, by proteolytic removal of an N-terminal inhibitory domain containing cytoplasmic retention motifs. SSY5 binds as an inactive protease complex to STP1. In response to extracellular amino acids and dependent on the other SPS-sensor components, the inhibitory propeptide is induced to dissociate, and thereby enables the catalytic domain to process STP1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW31", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0016485 protein processing;GO:0016540 protein autoprocessing;GO:0043200 response to amino acid", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P47002-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47005-1", "uniprot_id": [ { "id": "DAS1_YEAST", "url": "https://www.uniprot.org/uniprot/P47005", "type": "external" } ], "mass": 77367.0, "length": 663, "protein_name": "F-box protein DAS1", "gene_name": "DAS1", "organism": "Yeast", "refseq_name": "SCF ubiquitin ligase complex subunit DAS1", "refseq_ac": [ { "id": "NP_012386", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012386", "type": "external" } ], "gene_names_uniprotkb": "DAS1; J0634", "gene_names_refseq": "DAS1; DUH1", "protein_names_uniprotkb": "F-box protein DAS1; DST1-delta 6-azauracil sensitivity protein 1", "protein_names_refseq": "SCF ubiquitin ligase complex subunit DAS1", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL149W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10385629;10582239;14562106;14747994;19882662;23749301;24374639;8641269;8813765", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW36", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0000409 regulation of transcription by galactose", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P47005-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47006-1", "uniprot_id": [ { "id": "RPA34_YEAST", "url": "https://www.uniprot.org/uniprot/P47006", "type": "external" } ], "mass": 26875.0, "length": 233, "protein_name": "DNA-directed RNA polymerase I subunit RPA34", "gene_name": "RPA34", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase I subunit RPA34", "refseq_ac": [ { "id": "NP_012387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012387", "type": "external" } ], "gene_names_uniprotkb": "RPA34; J0637", "gene_names_refseq": "CST21; RPA34", "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit RPA34; A34.5; A34; DNA-directed DNA-dependent RNA polymerase 34.5 kDa polypeptide", "protein_names_refseq": "DNA-directed RNA polymerase I subunit RPA34", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL148W)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "11717393;11918799;12145213;12407181;14562095;14562106;17330950;18084032;18160037;18407956;19684113;19779198;19795423;19823750;20797630;23749301;24153182;24153184;24374639;30516470;32597660;33481703;33491328;8641269;8813765;9121426", "class_list": "", "function": "DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. The heterodimer formed by RPA34 and RPA49 stimulates transcript elongation by Pol I., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW37", "ec_number_list": [], "go_molecular_function": "GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005736 RNA polymerase I complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042254 ribosome biogenesis;GO:0006362 transcription elongation by RNA polymerase I;GO:0006361 transcription initiation at RNA polymerase I promoter;GO:0006363 termination of RNA polymerase I transcription", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P47006-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47008-1", "uniprot_id": [ { "id": "SFH5_YEAST", "url": "https://www.uniprot.org/uniprot/P47008", "type": "external" } ], "mass": 34388.0, "length": 294, "protein_name": "Phosphatidylinositol transfer protein SFH5", "gene_name": "SFH5", "organism": "Yeast", "refseq_name": "Sfh5p", "refseq_ac": [ { "id": "NP_012390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012390", "type": "external" } ], "gene_names_uniprotkb": "SFH5; J0644", "gene_names_refseq": "SFH5", "protein_names_uniprotkb": "Phosphatidylinositol transfer protein SFH5; PITP SFH5; SEC14 homolog 5", "protein_names_refseq": "Sfh5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL145W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10848624;12869188;14562095;14562106;16709158;17322287;24374639;32780017;8641269;8813765", "class_list": "", "function": "Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses (PubMed:32780017)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW40;Q6Q535", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0008526 phosphatidylinositol transfer activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015914 phospholipid transport;GO:0043001 Golgi to plasma membrane protein transport;GO:0046488 phosphatidylinositol metabolic process;GO:2000114 regulation of establishment of cell polarity;GO:0017157 regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P47008-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47011-1", "uniprot_id": [ { "id": "GLG2_YEAST", "url": "https://www.uniprot.org/uniprot/P47011", "type": "external" } ], "mass": 44546.0, "length": 380, "protein_name": "Glycogenin-2", "gene_name": "GLG2", "organism": "Yeast", "refseq_name": "glycogenin glucosyltransferase GLG2", "refseq_ac": [ { "id": "NP_012398", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012398", "type": "external" } ], "gene_names_uniprotkb": "GLG2; J0663", "gene_names_refseq": "GLG2", "protein_names_uniprotkb": "Glycogenin-2; 2.4.1.186; Glycogen synthesis initiator protein 2; Glycogenin glucosyltransferase 2", "protein_names_refseq": "glycogenin glucosyltransferase GLG2", "tax_id": 559292, "disease": "glycogen storage disease XV (Disease Ontology:DOID:0050579)", "pathway": " (sce:YJL137C); (R-SCE-3322077); (R-SCE-6798695); (R-SCE-70221)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "14562095;14562106;15479227;24374639;38832010;8524228;8641269;8813765;8900126", "class_list": "", "function": "Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase (PubMed:15479227, PubMed:8524228, PubMed:8900126). Capable of transferring glucosyl residues to unbound acceptors such as free oligoglucans or oligoglucan derivatives (PubMed:8900126)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VW47", "ec_number_list": [ { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.4.23.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.25", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.4.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.11", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.7.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.59", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.3.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10", "type": "external" } ], "go_molecular_function": "GO:0008466 glycogenin glucosyltransferase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005773 vacuole", "go_biological_process": "GO:0005978 glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P47011-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47013-1", "uniprot_id": [ { "id": "DS1P1_YEAST", "url": "https://www.uniprot.org/uniprot/P47013", "type": "external" } ], "mass": 47372.0, "length": 409, "protein_name": "Dihydrosphingosine 1-phosphate phosphatase LCB3", "gene_name": "LCB3", "organism": "Yeast", "refseq_name": "sphinganine kinase LCB3", "refseq_ac": [ { "id": "NP_012401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012401", "type": "external" } ], "gene_names_uniprotkb": "LCB3; J0671; LBP1; YSR2", "gene_names_refseq": "LBP1; LCB3; YSR2", "protein_names_uniprotkb": "Dihydrosphingosine 1-phosphate phosphatase LCB3; 3.1.3.-; Long-chain base protein 3; Sphingolipid resistance protein 2", "protein_names_refseq": "sphinganine kinase LCB3", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL134W); (R-SCE-9845614)", "pathway_count": 2, "publication_count": 28, "publication_id_list": "10477278;10563329;10856228;11278643;11967828;12493772;12684378;12786943;15665377;16847258;17330950;17563356;18407956;19684113;19779198;20702584;21177495;22814378;24374639;25345524;32597660;33481703;33491328;8641269;8813765;9195906;9353337;9419344", "class_list": "", "function": "Dihydrosphingosine 1-phosphate phosphatase required for efficient ceramide synthesis from exogenous sphingoid bases (PubMed:10477278, PubMed:10563329, PubMed:10856228, PubMed:11278643, PubMed:11967828, PubMed:12493772, PubMed:12684378, PubMed:12786943, PubMed:25345524, PubMed:9195906, PubMed:9353337, PubMed:9419344). Involved in endocytosis and calcium-mediated signaling (PubMed:10856228, PubMed:11278643)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW50", "ec_number_list": [ { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0070780 dihydrosphingosine-1-phosphate phosphatase activity;GO:0042392 sphingosine-1-phosphate phosphatase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0030148 sphingolipid biosynthetic process;GO:0046839 phospholipid dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P47013-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47016-1", "uniprot_id": [ { "id": "NIT2_YEAST", "url": "https://www.uniprot.org/uniprot/P47016", "type": "external" } ], "mass": 34693.0, "length": 307, "protein_name": "Deaminated glutathione amidase", "gene_name": "NIT2", "organism": "Yeast", "refseq_name": "putative hydrolase", "refseq_ac": [ { "id": "NP_012409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012409", "type": "external" } ], "gene_names_uniprotkb": "NIT2; J0706", "gene_names_refseq": "NIT2", "protein_names_uniprotkb": "Deaminated glutathione amidase; 3.5.1.128; Nitrilase homolog 1; dGSH amidase", "protein_names_refseq": "putative hydrolase", "tax_id": 559292, "disease": "brain small vessel disease 4 (Disease Ontology:DOID:0061234)", "pathway": " (sce:YJL126W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10959838;23897470;24374639;28373563;33481703;8641269;8948101", "class_list": "", "function": "Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione (PubMed:28373563). Possesses amidase activity toward deaminated ophthalmate in vitro (PubMed:28373563)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW60;Q71SQ0", "ec_number_list": [ { "id": "3.5.1.128", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.128", "type": "external" } ], "go_molecular_function": "GO:0050406 [acetyl-CoA carboxylase]-phosphatase activity;GO:0110050 deaminated glutathione amidase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0043605 amide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P47016-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47024-1", "uniprot_id": [ { "id": "YJ41B_YEAST", "url": "https://www.uniprot.org/uniprot/P47024", "type": "external" } ], "mass": 207710.0, "length": 1803, "protein_name": "Transposon Ty4-J Gag-Pol polyprotein", "gene_name": "TY4B-J", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": [ { "id": "NP_012421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012421", "type": "external" } ], "gene_names_uniprotkb": "TY4B-J; J0780; YJLWTy4-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty4-J Gag-Pol polyprotein; TY4A-TY4B; Transposon Ty4 TYA-TYB polyprotein", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL113W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1328182;16093660;24374639;8641269;8948101;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VW70;P87192", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.26.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.4", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P47024-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47025-1", "uniprot_id": [ { "id": "MDV1_YEAST", "url": "https://www.uniprot.org/uniprot/P47025", "type": "external" } ], "mass": 80032.0, "length": 714, "protein_name": "Mitochondrial division protein 1", "gene_name": "MDV1", "organism": "Yeast", "refseq_name": "Mdv1p", "refseq_ac": [ { "id": "NP_012423", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012423", "type": "external" } ], "gene_names_uniprotkb": "MDV1; FIS2; GAG3; J0802; NET2", "gene_names_refseq": "GAG3; MDV1; NET2", "protein_names_uniprotkb": "Mitochondrial division protein 1; Mitochondria fission 2 protein", "protein_names_refseq": "Mdv1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL112W)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "11038180;11038182;11038183;12163467;14517324;14562095;14562106;15809300;16009724;16247028;16272155;16407407;16601120;16823961;18407956;19779198;19795423;19823750;20702584;21177495;23530241;23749301;24374639;30516470;32597660;33481703;33491328;7483851;8641269;8948101", "class_list": "", "function": "Involved in mitochondrial fission. Has a partially redundant function to CAF4 in acting as an adapter protein, binding to FIS1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase DNM1 to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW72", "ec_number_list": [], "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0016559 peroxisome fission;GO:0000266 mitochondrial fission;GO:0090141 positive regulation of mitochondrial fission", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P47025-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47026-1", "uniprot_id": [ { "id": "GWT1_YEAST", "url": "https://www.uniprot.org/uniprot/P47026", "type": "external" } ], "mass": 55466.0, "length": 490, "protein_name": "GPI-anchored wall transfer protein 1", "gene_name": "GWT1", "organism": "Yeast", "refseq_name": "glucosaminyl-phosphotidylinositol O-acyltransferase", "refseq_ac": [ { "id": "NP_012444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012444", "type": "external" } ], "gene_names_uniprotkb": "GWT1; J0916", "gene_names_refseq": "GWT1", "protein_names_uniprotkb": "GPI-anchored wall transfer protein 1; 2.3.-.-", "protein_names_refseq": "glucosaminyl-phosphotidylinositol O-acyltransferase", "tax_id": 559292, "disease": "hyperphosphatasia with impaired intellectual development syndrome 5 (Disease Ontology:DOID:0070432)", "pathway": " (sce:YJL091C); (R-SCE-162710)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12714589;12753194;14562095;14690591;16361252;16847258;24374639;7483841;8641269", "class_list": "", "function": "Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW93", "ec_number_list": [ { "id": "2.3.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.-.-", "type": "external" } ], "go_molecular_function": "GO:0032216 glucosaminyl-phosphatidylinositol O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P47026-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47029-1", "uniprot_id": [ { "id": "ALY2_YEAST", "url": "https://www.uniprot.org/uniprot/P47029", "type": "external" } ], "mass": 117216.0, "length": 1046, "protein_name": "Arrestin-related trafficking adapter 3", "gene_name": "ALY2", "organism": "Yeast", "refseq_name": "Aly2p", "refseq_ac": [ { "id": "NP_012451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012451", "type": "external" } ], "gene_names_uniprotkb": "ALY2; ART3; J0934", "gene_names_refseq": "ALY2; ART3", "protein_names_uniprotkb": "Arrestin-related trafficking adapter 3; Arrestin-like protein 2", "protein_names_refseq": "Aly2p", "tax_id": 559292, "disease": "stomach cancer (Disease Ontology:DOID:10534); Reye syndrome (Disease Ontology:DOID:14525); glaucoma (Disease Ontology:DOID:1686); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YJL084C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "12098764;14562095;14562106;15665377;17330950;17551511;17563356;18407956;18976803;19684113;19779198;20702584;21126336;21177495;23749301;24374639;24909858;30610170;32597660;33229814;33481703;33491328;7483841;8641269", "class_list": "", "function": "May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 70, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VW99;Q05742", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005770 late endosome", "go_biological_process": "GO:2000397 positive regulation of ubiquitin-dependent endocytosis;GO:0051453 regulation of intracellular pH;GO:1903577 cellular response to L-arginine;GO:0070086 ubiquitin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P47029-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47030-1", "uniprot_id": [ { "id": "TAX4_YEAST", "url": "https://www.uniprot.org/uniprot/P47030", "type": "external" } ], "mass": 68768.0, "length": 604, "protein_name": "Protein TAX4", "gene_name": "TAX4", "organism": "Yeast", "refseq_name": "Tax4p", "refseq_ac": [ { "id": "NP_012452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012452", "type": "external" } ], "gene_names_uniprotkb": "TAX4; J1002", "gene_names_refseq": "TAX4", "protein_names_uniprotkb": "Protein TAX4", "protein_names_refseq": "Tax4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL083W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;15265867;24374639;33481703;33491328;7483841;8641269;9822599", "class_list": "", "function": "With IRS4, acts as a positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover. Negatively regulates signaling through the cell integrity pathway, including the MAP kinase SLT2., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWA0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000407 phagophore assembly site", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006914 autophagy;GO:0009267 cellular response to starvation;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P47030-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47032-1", "uniprot_id": [ { "id": "PRY1_YEAST", "url": "https://www.uniprot.org/uniprot/P47032", "type": "external" } ], "mass": 30634.0, "length": 299, "protein_name": "Protein PRY1", "gene_name": "PRY1", "organism": "Yeast", "refseq_name": "sterol-binding protein", "refseq_ac": [ { "id": "NP_012456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012456", "type": "external" } ], "gene_names_uniprotkb": "PRY1; J1022", "gene_names_refseq": "PRY1", "protein_names_uniprotkb": "Protein PRY1; Pathogenesis-related protein 1", "protein_names_refseq": "sterol-binding protein", "tax_id": 559292, "disease": "pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498)", "pathway": " (sce:YJL079C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11935221;14562106;17322287;23027975;24374639;7483841;8641269", "class_list": "", "function": "Secreted protein required for efficient export of lipids such as acetylated sterols. Acts in detoxification of hydrophobic compounds., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWA4", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005504 fatty acid binding;GO:0032934 sterol binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0015908 fatty acid transport;GO:0015918 sterol transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P47032-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47033-1", "uniprot_id": [ { "id": "PRY3_YEAST", "url": "https://www.uniprot.org/uniprot/P47033", "type": "external" } ], "mass": 89153.0, "length": 881, "protein_name": "Cell wall protein PRY3", "gene_name": "PRY3", "organism": "Yeast", "refseq_name": "Pry3p", "refseq_ac": [ { "id": "NP_012457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012457", "type": "external" } ], "gene_names_uniprotkb": "PRY3; J1027", "gene_names_refseq": "PRY3", "protein_names_uniprotkb": "Cell wall protein PRY3; Pathogenesis-related protein 3", "protein_names_refseq": "Pry3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL078C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11747810;15781460;16420678;16940175;23027975;23038983;23523622;24374639;7483841;8641269;9613572", "class_list": "", "function": "The full-length isoform (isoform Long) is a daughter cell-specific cell wall protein required for efficient export of lipids such as acetylated sterols. Acts in detoxification of hydrophobic compounds. Involved in tolerance to organic solvents such as dimethyl sulfoxide (DMSO). Also plays a role as an inhibitor of mating. STE12 is utilized as a repressor of full-length PRY3 transcription, ensuring efficient mating., [UniProtKB]; There is no evidence that production of the short PRY3 transcript (isoform Short) is anything more than an adventitious by-product of the mechanism responsible for the repression of the full-length transcript. Moreover, no disadvantage is detectable for cells unable to make the short transcript (PubMed:16940175)., [UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6VWA5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0071944 cell periphery;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0015908 fatty acid transport;GO:0015918 sterol transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P47033-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47039-1", "uniprot_id": [ { "id": "BNA3_YEAST", "url": "https://www.uniprot.org/uniprot/P47039", "type": "external" } ], "mass": 50082.0, "length": 444, "protein_name": "Probable kynurenine--oxoglutarate transaminase BNA3", "gene_name": "BNA3", "organism": "Yeast", "refseq_name": "kynurenine--oxoglutarate transaminase", "refseq_ac": [ { "id": "NP_012475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012475", "type": "external" } ], "gene_names_uniprotkb": "BNA3; J1138", "gene_names_refseq": "BNA3", "protein_names_uniprotkb": "Probable kynurenine--oxoglutarate transaminase BNA3; 2.6.1.7; Biosynthesis of nicotinic acid protein 3; Kynurenine aminotransferase", "protein_names_refseq": "kynurenine--oxoglutarate transaminase", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL060W); (R-SCE-71240); (R-SCE-8964208); (R-SCE-8964539)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "14562095;14562106;16823961;18205391;18407956;24374639;33491328;8641269", "class_list": "", "function": "Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWC2", "ec_number_list": [ { "id": "2.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.7", "type": "external" }, { "id": "2.6.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.57", "type": "external" } ], "go_molecular_function": "GO:0016212 kynurenine-oxoglutarate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0047536 2-aminoadipate transaminase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0097053 L-kynurenine catabolic process;GO:0034276 kynurenic acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P47039-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47043-1", "uniprot_id": [ { "id": "ZAP1_YEAST", "url": "https://www.uniprot.org/uniprot/P47043", "type": "external" } ], "mass": 98866.0, "length": 880, "protein_name": "Zinc-responsive transcriptional regulator ZAP1", "gene_name": "ZAP1", "organism": "Yeast", "refseq_name": "Zap1p", "refseq_ac": [ { "id": "NP_012479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012479", "type": "external" } ], "gene_names_uniprotkb": "ZAP1; J1145", "gene_names_refseq": "ZAP1; ZRG10", "protein_names_uniprotkb": "Zinc-responsive transcriptional regulator ZAP1", "protein_names_refseq": "Zap1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL056C)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10899124;12549926;14517251;16045625;16483601;16720702;19779198;21126336;21177495;21177862;21799889;22950018;24374639;26711224;32597660;33481703;33491328;8641269;9271382;9786867", "class_list": "", "function": "Transcription regulator controlling zinc-responsive gene expression. Binds to zinc-responsive elements (ZREs) (consensus sequence 5'-ACCYYNAAGGT-3') in the promoter of target genes (PubMed:9786867). Recruits SWI/SNF, SAGA, and Mediator complexes as coactivators in a zinc-responsive manner (PubMed:22950018). Involved in zinc ion homeostasis by zinc-responsive transcriptional regulation of the zinc uptake system genes ZTR1 and ZTR2 (PubMed:9271382). Positively regulates ETR1 expression, affecting mitochondrial function (PubMed:26711224)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VWC6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034224 cellular response to zinc ion starvation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P47043-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47045-1", "uniprot_id": [ { "id": "TIM54_YEAST", "url": "https://www.uniprot.org/uniprot/P47045", "type": "external" } ], "mass": 54183.0, "length": 478, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM54", "gene_name": "TIM54", "organism": "Yeast", "refseq_name": "Tim22-complex subunit TIM54", "refseq_ac": [ { "id": "NP_012481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012481", "type": "external" } ], "gene_names_uniprotkb": "TIM54; J1150", "gene_names_refseq": "TIM54", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM54", "protein_names_refseq": "Tim22-complex subunit TIM54", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL054W); (R-SCE-1660661); (R-SCE-390471); (R-SCE-5218921); (R-SCE-9009391); (R-SCE-9833482)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "10397776;10637294;10648604;11864609;12637749;14562095;21126336;22814378;24374639;8641269;9412462", "class_list": "", "function": "Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force. Its precise function within the TIM22 complex is unclear., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWC8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0045039 protein insertion into mitochondrial inner membrane;GO:0071806 protein transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P47045-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47050-1", "uniprot_id": [ { "id": "CUL8_YEAST", "url": "https://www.uniprot.org/uniprot/P47050", "type": "external" } ], "mass": 99326.0, "length": 842, "protein_name": "Cullin-8", "gene_name": "RTT101", "organism": "Yeast", "refseq_name": "cullin RTT101", "refseq_ac": [ { "id": "NP_012488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012488", "type": "external" } ], "gene_names_uniprotkb": "RTT101; CUL8; J1166", "gene_names_refseq": "CUL8; RTT101", "protein_names_uniprotkb": "Cullin-8; Cullin-C; Regulator of Ty1 transposition protein 101", "protein_names_refseq": "cullin RTT101", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL047C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11779788;12676951;14519104;14562095;16631586;17978089;18321796;18704118;19390089;20139071;20634314;21593207;22814378;23749301;24209620;24374639;33481703;33491328;8641269", "class_list": "", "function": "Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes (CRLs), which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The CRL associates with CDC34 as the E2 ubiquitin-conjugating enzyme. The functional specificity of the CRL depends on the type of the associated substrate receptor protein. RTT101(MMS1-MMS22) promotes fork progression through damaged DNA or natural pause sites by stabilizing replication proteins like the replication fork-pausing complex (FPC) and leading-strand polymerase at stalled replication forks. RTT101(MMS1-MMS22) ubiquitinates the acetylated histones H3K56ac-H4 at lysine residues H3K121, H3K122 and H3K125. Ubiquitination is required for efficient histone deposition during replication-coupled nucleosome assembly, probably by facilitating the transfer of H3-H4 from ASF1 to other chaperones involved in histone deposition. RTT101(MMS1-CRT10) may regulate nucleotide synthesis through transcriptional regulation of ribonucleotide reductase. RTT101(MMS1) is also involved in the non-functional rRNA decay (NRD) of 25S rRNA through the selective, ubiquitination-dependent degradation of nonfunctional ribosomal particles. Ubiquitinates the FACT (facilitates chromatin transcription) complex subunit SPT16 in an MMS1-independent manner. Involved in regulation of Ty1 transposition and protects the genome from Ty1 integration upstream of tRNA genes., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWD7", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0160072 ubiquitin ligase complex scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0035361 Cul8-RING ubiquitin ligase complex", "go_biological_process": "GO:0070651 nonfunctional rRNA decay;GO:0006281 DNA repair;GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P47050-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47057-1", "uniprot_id": [ { "id": "SNX4_YEAST", "url": "https://www.uniprot.org/uniprot/P47057", "type": "external" } ], "mass": 49002.0, "length": 423, "protein_name": "Sorting nexin-4", "gene_name": "SNX4", "organism": "Yeast", "refseq_name": "Snx4p", "refseq_ac": [ { "id": "NP_012498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012498", "type": "external" } ], "gene_names_uniprotkb": "SNX4; ATG24; CVT13; J1244", "gene_names_refseq": "ATG24; CVT13; SNX4", "protein_names_uniprotkb": "Sorting nexin-4; Autophagy-related protein 24; Cytoplasm to vacuole targeting protein 13", "protein_names_refseq": "Snx4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL036W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12048214;12554655;14536056;14562095;14562106;15800066;17322287;17420293;18818209;19684113;19793921;20729555;20861302;21429936;24374639;38832010;8641269;8663607", "class_list": "", "function": "Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells (PubMed:12048214, PubMed:12554655, PubMed:15800066, PubMed:17420293, PubMed:18818209, PubMed:19793921, PubMed:20729555, PubMed:20861302, PubMed:21429936, PubMed:8663607). Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), and autophagy of large cargos including mitophagy, pexophagy and glycophagy (PubMed:12048214, PubMed:12554655, PubMed:15800066, PubMed:17420293, PubMed:18818209, PubMed:19793921, PubMed:20729555, PubMed:20861302, PubMed:21429936, PubMed:38832010, PubMed:8663607). Involved in proper sorting of the v-SNARE protein SNC1 (PubMed:12554655)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWE7;Q06794", "ec_number_list": [], "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0015031 protein transport;GO:0016236 macroautophagy;GO:0036010 protein localization to endosome;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P47057-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47058-1", "uniprot_id": [ { "id": "ADAT2_YEAST", "url": "https://www.uniprot.org/uniprot/P47058", "type": "external" } ], "mass": 28252.0, "length": 250, "protein_name": "tRNA-specific adenosine-34 deaminase catalytic subunit TAD2", "gene_name": "TAD2", "organism": "Yeast", "refseq_name": "tRNA(adenine34) deaminase", "refseq_ac": [ { "id": "NP_012499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012499", "type": "external" } ], "gene_names_uniprotkb": "TAD2; J1246", "gene_names_refseq": "TAD2", "protein_names_uniprotkb": "tRNA-specific adenosine-34 deaminase catalytic subunit TAD2; 3.5.4.33", "protein_names_refseq": "tRNA(adenine34) deaminase", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL035C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10550050;14562095;14562106;17322287;24374639;33272269;8641269;8893855", "class_list": "", "function": "Catalytic subunit of the tRNA-specific adenosine-34 deaminase complex, composed of the TAD2 catalytic subunit and the TAD3 regulatory subunit, which deaminates adenosine-34 (the first, also called wobble position of the anticodon) to inosine in many tRNAs. Inosine-34 allows the decoding of 3 different nucleotides at the third position of mRNA codons, as inosine is able to pair with U, C, and A., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWE8", "ec_number_list": [ { "id": "3.5.4.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.33", "type": "external" } ], "go_molecular_function": "GO:0008251 tRNA-specific adenosine deaminase activity;GO:0008270 zinc ion binding;GO:0052717 tRNA-specific adenosine-34 deaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0052718 tRNA-specific adenosine-34 deaminase complex", "go_biological_process": "GO:0002100 tRNA wobble adenosine to inosine editing;GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P47058-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47075-1", "uniprot_id": [ { "id": "VTC4_YEAST", "url": "https://www.uniprot.org/uniprot/P47075", "type": "external" } ], "mass": 83155.0, "length": 721, "protein_name": "Vacuolar transporter chaperone complex subunit 4", "gene_name": "VTC4", "organism": "Yeast", "refseq_name": "Vtc4p", "refseq_ac": [ { "id": "NP_012522", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012522", "type": "external" } ], "gene_names_uniprotkb": "VTC4; J1345; PHM3", "gene_names_refseq": "PHM3; VTC4; YJL012C-A", "protein_names_uniprotkb": "Vacuolar transporter chaperone complex subunit 4; 2.7.4.1; Phosphate metabolism protein 3; PolyP polymerase; Polyphosphate kinase; SPX-dependent polyphosphate polymerase VTC subunit 4; Vacuolar membrane polyphosphate polymerase catalytic subunit", "protein_names_refseq": "Vtc4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL012C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10480897;11102525;11823419;12584253;12844361;14562106;17079729;18407956;19390046;22106047;24114837;24374639;25315834;26928762;27080106;27587415;27774698;28186404;32597660;32776922;33481703;8641269", "class_list": "", "function": "Catalytic subunit of the vacuolar transporter chaperone (VTC) complex. The VTC complex acts as a vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP. VTC exposes its catalytic domain VTC4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation (PubMed:19390046). The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen (PubMed:19390046, PubMed:25315834). PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase (PubMed:25315834). The VTC complex also plays a role in vacuolar membrane fusion (PubMed:11102525, PubMed:11823419, PubMed:12584253). Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation (PubMed:11823419). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules. Inositol polyphosphate binding promotes vacuolar polyphosphate synthesis (PubMed:27080106). The VTC complex is required for microautophagy. It is a constituent of autophagic tubes and is required for scission of microautophagic vesicles from these tubes (PubMed:17079729)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWG5;Q7Z872;Q86ZR4", "ec_number_list": [ { "id": "2.7.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.1", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0000822 inositol hexakisphosphate binding;GO:0008976 polyphosphate kinase activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005783 endoplasmic reticulum;GO:0005938 cell cortex;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007034 vacuolar transport;GO:0061736 engulfment of target by autophagosome;GO:0006797 polyphosphate metabolic process;GO:0016237 microautophagy;GO:0006799 polyphosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P47075-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47077-1", "uniprot_id": [ { "id": "NOP9_YEAST", "url": "https://www.uniprot.org/uniprot/P47077", "type": "external" } ], "mass": 77722.0, "length": 666, "protein_name": "Nucleolar protein 9", "gene_name": "NOP9", "organism": "Yeast", "refseq_name": "RNA-binding RNA processing protein NOP9", "refseq_ac": [ { "id": "NP_012524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012524", "type": "external" } ], "gene_names_uniprotkb": "NOP9; J1357", "gene_names_refseq": "NOP9", "protein_names_uniprotkb": "Nucleolar protein 9; Pumilio domain-containing protein NOP9", "protein_names_refseq": "RNA-binding RNA processing protein NOP9", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL010C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;14690591;16544271;17956976;23749301;24374639;33491328;8641269", "class_list": "", "function": "RNA-binding nucleolar protein required for pre-rRNA processing. Component of the 90S pre-ribosome involved in production of 18S rRNA and assembly of small ribosomal subunit. Component of the pre-40S ribosome required for release from the nucleolus., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWG7", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0030688 preribosome, small subunit precursor;GO:0030686 90S preribosome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000056 ribosomal small subunit export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P47077-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47082-1", "uniprot_id": [ { "id": "AVT1_YEAST", "url": "https://www.uniprot.org/uniprot/P47082", "type": "external" } ], "mass": 65346.0, "length": 602, "protein_name": "Vacuolar amino acid transporter 1", "gene_name": "AVT1", "organism": "Yeast", "refseq_name": "Avt1p", "refseq_ac": [ { "id": "NP_012534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012534", "type": "external" } ], "gene_names_uniprotkb": "AVT1; J1409; YJR83.4", "gene_names_refseq": "AVT1", "protein_names_uniprotkb": "Vacuolar amino acid transporter 1", "protein_names_refseq": "Avt1p", "tax_id": 559292, "disease": "generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); alcohol use disorder (Disease Ontology:DOID:1574); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (sce:YJR001W); (R-SCE-442660); (R-SCE-888590)", "pathway_count": 3, "publication_count": 24, "publication_id_list": "11274162;14562106;16847258;17330950;18407956;19684113;19779198;19795423;19823750;21126336;21177495;22218487;23749301;24374639;24909858;25747199;30516470;31636363;32597660;32776922;33481703;33491328;34965436;8641269", "class_list": "", "function": "Amino acid/proton antiporter that moves various amino acids into the vacuole, with a preference for large neutral ones and histidine., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 28, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWH5", "ec_number_list": [], "go_molecular_function": "GO:0015188 L-isoleucine transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015186 L-glutamine transmembrane transporter activity;GO:0005290 L-histidine transmembrane transporter activity;GO:0005302 L-tyrosine transmembrane transporter activity", "go_cellular_component": "GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0007034 vacuolar transport;GO:0015824 proline transport;GO:0006865 amino acid transport;GO:0003333 amino acid transmembrane transport;GO:0090513 L-histidine transmembrane import into vacuole", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P47082-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47093-1", "uniprot_id": [ { "id": "LSM8_YEAST", "url": "https://www.uniprot.org/uniprot/P47093", "type": "external" } ], "mass": 12385.0, "length": 109, "protein_name": "LSM2-LSM8 complex subunit LSM8", "gene_name": "LSM8", "organism": "Yeast", "refseq_name": "U4/U6-U5 snRNP complex subunit LSM8", "refseq_ac": [ { "id": "NP_012556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012556", "type": "external" } ], "gene_names_uniprotkb": "LSM8; J1464; YJR83.16", "gene_names_refseq": "LSM8", "protein_names_uniprotkb": "LSM2-LSM8 complex subunit LSM8", "protein_names_refseq": "U4/U6-U5 snRNP complex subunit LSM8", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR022W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10449419;10747033;12077351;12438310;12748633;14562095;14562106;15075370;15485930;18953335;22814378;24240276;24374639;29717126;8619316;8641269", "class_list": "", "function": "Component of the nuclear LSM2-LSM8 complex, which is involved in spliceosome assembly (PubMed:10747033, PubMed:12077351, PubMed:12438310). The LSM2-LSM8 complex plays a role in the biogenesis of the spliceosomal U4/U6-U5 tri-snRNP complex by accelerating PRP24-mediated annealing of U4/U6 di-snRNA (PubMed:10747033, PubMed:24240276, PubMed:29717126). The LSM2-LSM8 complex binds U6 snRNA terminating with a non-cyclic 3' phosphate group (PubMed:29717126). LSM2-LSM8 is probably also involved in degradation of nuclear pre-mRNA by targeting them for decapping (PubMed:15485930). LSM2-LSM8 could be involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA, although involvement may be indirect (PubMed:12077351, PubMed:12438310, PubMed:15075370)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWJ6", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0071011 precatalytic spliceosome;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0000398 mRNA splicing, via spliceosome;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P47093-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47096-1", "uniprot_id": [ { "id": "3HAO_YEAST", "url": "https://www.uniprot.org/uniprot/P47096", "type": "external" } ], "mass": 20235.0, "length": 177, "protein_name": "3-hydroxyanthranilate 3,4-dioxygenase", "gene_name": "BNA1", "organism": "Yeast", "refseq_name": "3-hydroxyanthranilate 3,4-dioxygenase", "refseq_ac": [ { "id": "NP_012559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012559", "type": "external" } ], "gene_names_uniprotkb": "BNA1; HAD1; J1550", "gene_names_refseq": "BNA1; HAD1", "protein_names_uniprotkb": "3-hydroxyanthranilate 3,4-dioxygenase; 1.13.11.6; 3-HAO; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; Biosynthesis of nicotinic acid protein 1; HAD", "protein_names_refseq": "3-hydroxyanthranilate 3,4-dioxygenase", "tax_id": 559292, "disease": "Huntington's disease (Disease Ontology:DOID:12858); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (sce:YJR025C); (R-SCE-71240)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "14562095;14562106;15665377;16522801;17322287;17330950;18407956;19684113;19779198;19795423;19823750;21126336;23749301;24374639;24909858;33481703;33491328;8619316;8641269;9539135", "class_list": "", "function": "Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VWJ8", "ec_number_list": [ { "id": "1.13.11.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.6", "type": "external" } ], "go_molecular_function": "GO:0000334 3-hydroxyanthranilate 3,4-dioxygenase activity;GO:0008198 ferrous iron binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006569 L-tryptophan catabolic process;GO:0019805 quinolinate biosynthetic process;GO:0043420 anthranilate metabolic process;GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan;GO:0046874 quinolinate metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P47096-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47098-1", "uniprot_id": [ { "id": "YJ11B_YEAST", "url": "https://www.uniprot.org/uniprot/P47098", "type": "external" } ], "mass": 198652.0, "length": 1755, "protein_name": "Transposon Ty1-JR1 Gag-Pol polyprotein", "gene_name": "TY1B-JR1", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": [ { "id": "NP_012560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012560", "type": "external" } ], "gene_names_uniprotkb": "TY1B-JR1; J1560; YJRWTy1-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-JR1 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR027W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16093660;16093680;17287358;19779198;24374639;8619316;8641269;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VWJ9;P87194", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.26.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.4", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P47098-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47100-1", "uniprot_id": [ { "id": "YJ12B_YEAST", "url": "https://www.uniprot.org/uniprot/P47100", "type": "external" } ], "mass": 198618.0, "length": 1755, "protein_name": "Transposon Ty1-JR2 Gag-Pol polyprotein", "gene_name": "TY1B-JR2", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": [ { "id": "NP_012562", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012562", "type": "external" } ], "gene_names_uniprotkb": "TY1B-JR2; J1570; YJRWTy1-2 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-JR2 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR029W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16093660;16093680;17287358;24374639;33229814;8619316;8641269;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "D6VWK1;P87195", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.26.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.4", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P47100-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47112-1", "uniprot_id": [ { "id": "CDT1_YEAST", "url": "https://www.uniprot.org/uniprot/P47112", "type": "external" } ], "mass": 68405.0, "length": 604, "protein_name": "Cell division cycle protein CDT1", "gene_name": "TAH11", "organism": "Yeast", "refseq_name": "Tah11p", "refseq_ac": [ { "id": "NP_012580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012580", "type": "external" } ], "gene_names_uniprotkb": "TAH11; CDT1; J1641; SID2", "gene_names_refseq": "CDT1; SID2; TAH11", "protein_names_uniprotkb": "Cell division cycle protein CDT1; SIC1 indispensable protein 2; Topoisomerase-A hypersensitive protein 11", "protein_names_refseq": "Tah11p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR046W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11560884;11836525;11967159;14562106;16387651;16824194;17825064;18006685;18407956;19684113;19896182;21126336;23749301;24374639;33229814;33481703;33491328;7668047;8641269", "class_list": "", "function": "DNA replication licensing factor, required for pre-replication complex assembly. Faithful duplication of the genetic material requires 'once per cell cycle' DNA replication initiation and elongation. Central to this control is the tightly regulated formation of prereplicative complexes (preRCs) at future origins of DNA replication. Required for the recruitment of the MCM2-7 helicase complex to the replication origins., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VWL7", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding", "go_cellular_component": "GO:0005656 nuclear pre-replicative complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication;GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0051301 cell division;GO:0000727 double-strand break repair via break-induced replication", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P47112-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47114-1", "uniprot_id": [ { "id": "KCH1_YEAST", "url": "https://www.uniprot.org/uniprot/P47114", "type": "external" } ], "mass": 57517.0, "length": 497, "protein_name": "Low affinity K(+) transporter 1", "gene_name": "KCH1", "organism": "Yeast", "refseq_name": "Kch1p", "refseq_ac": [ { "id": "NP_012588", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012588", "type": "external" } ], "gene_names_uniprotkb": "KCH1; J1669", "gene_names_refseq": "KCH1", "protein_names_uniprotkb": "Low affinity K(+) transporter 1", "protein_names_refseq": "Kch1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR054W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562095;14562106;16847258;18407956;19779198;21252230;23204190;23749301;24374639;33481703;33491328;8641269;8840504", "class_list": "", "function": "Low affinity potassium transporter that, with PRM6/KCH2, participates in high-affinity Ca(2+) influx system (HACS) activation during the response to mating pheromone (PubMed:21252230, PubMed:23204190). Directly promotes K(+) influx and HACS may electrochemically respond to this K(+) influx (PubMed:23204190). KCH1 and KCH2 act at the apex of the calcium signaling pathway that is used for survival during prolonged exposures to mating pheromones (PubMed:23204190)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWM5", "ec_number_list": [], "go_molecular_function": "GO:0015079 potassium ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005774 vacuolar membrane;GO:0000324 fungal-type vacuole;GO:0005937 mating projection", "go_biological_process": "GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P47114-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47116-1", "uniprot_id": [ { "id": "PTK2_YEAST", "url": "https://www.uniprot.org/uniprot/P47116", "type": "external" } ], "mass": 91400.0, "length": 818, "protein_name": "Serine/threonine-protein kinase PTK2/STK2", "gene_name": "PTK2", "organism": "Yeast", "refseq_name": "protein kinase PTK2", "refseq_ac": [ { "id": "NP_012593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012593", "type": "external" } ], "gene_names_uniprotkb": "PTK2; J1725; STK2", "gene_names_refseq": "PTK2; STK2", "protein_names_uniprotkb": "Serine/threonine-protein kinase PTK2/STK2; 2.7.11.1", "protein_names_refseq": "protein kinase PTK2", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR059W)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "11003661;14562095;14562106;17287358;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33229814;33481703;33491328;34965436;8641269;8840504;8920934;9154797", "class_list": "", "function": "Essential determinant for high-affinity spermidine transport. Required for the activation of the plasma membrane proton pump PMA1 via phosphorylation of 'Ser-899'., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 12, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 12, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 12, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 66, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "D6VWN0;E9P962", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0000296 spermine transport;GO:0000086 G2/M transition of mitotic cell cycle;GO:0000082 G1/S transition of mitotic cell cycle;GO:0006873 intracellular monoatomic ion homeostasis;GO:0015847 putrescine transport", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "P47116-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47117-1", "uniprot_id": [ { "id": "ARP3_YEAST", "url": "https://www.uniprot.org/uniprot/P47117", "type": "external" } ], "mass": 49542.0, "length": 449, "protein_name": "Actin-related protein 3", "gene_name": "ARP3", "organism": "Yeast", "refseq_name": "actin-related protein 3", "refseq_ac": [ { "id": "NP_012599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012599", "type": "external" } ], "gene_names_uniprotkb": "ARP3; ACT4; J1760", "gene_names_refseq": "ACT4; ARP3", "protein_names_uniprotkb": "Actin-related protein 3; Actin-like protein 3; Actin-like protein ARP3", "protein_names_refseq": "actin-related protein 3", "tax_id": 559292, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); opisthorchiasis (Disease Ontology:DOID:13768); glioblastoma (Disease Ontology:DOID:3068); gallbladder carcinoma (Disease Ontology:DOID:4948); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (sce:YJR065C); (R-SCE-2029482); (R-SCE-5663213)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "14562106;18407956;21126336;24374639;33491328;8641269;8840501;8840504;9210376", "class_list": "", "function": "Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWN6", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0005885 Arp2/3 protein complex;GO:0030479 actin cortical patch", "go_biological_process": "GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0045010 actin nucleation;GO:0044396 actin cortical patch organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P47117-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47119-1", "uniprot_id": [ { "id": "ITPA_YEAST", "url": "https://www.uniprot.org/uniprot/P47119", "type": "external" } ], "mass": 22093.0, "length": 197, "protein_name": "Inosine triphosphate pyrophosphatase", "gene_name": "HAM1", "organism": "Yeast", "refseq_name": "nucleoside triphosphate pyrophosphohydrolase HAM1", "refseq_ac": [ { "id": "NP_012603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012603", "type": "external" } ], "gene_names_uniprotkb": "HAM1; J1811", "gene_names_refseq": "HAM1", "protein_names_uniprotkb": "Inosine triphosphate pyrophosphatase; 3.6.1.66; Hydroxylaminopurine sensitivity protein 1; ITPase; Inosine triphosphatase; NTPase; Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; XTP/dITP diphosphatase", "protein_names_refseq": "nucleoside triphosphate pyrophosphohydrolase HAM1", "tax_id": 559292, "disease": "developmental and epileptic encephalopathy 35 (Disease Ontology:DOID:0080458); thrombocytopenia (Disease Ontology:DOID:1588); hepatitis C (Disease Ontology:DOID:1883); anemia (Disease Ontology:DOID:2355); hemolytic anemia (Disease Ontology:DOID:583); rheumatoid arthritis (Disease Ontology:DOID:7148); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (sce:YJR069C); (R-SCE-74259); (R-SCE-9755088)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "14562095;14562106;17090528;17322287;17899088;21126336;23749301;24374639;33491328;8641269;8789257;8840504;9918490", "class_list": "", "function": "Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and 5-bromodeoxyuridine 5'-triphosphate (BrdUTP) to their respective monophosphate derivatives. Xanthosine 5'-triphosphate (XTP) is also a potential substrate. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions., [UniProtKB, HAMAP, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWP0", "ec_number_list": [ { "id": "3.6.1.66", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.66", "type": "external" } ], "go_molecular_function": "GO:0047840 dCTP diphosphatase activity;GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0036219 GTP diphosphatase activity;GO:0047429 nucleoside triphosphate diphosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0009117 nucleotide metabolic process;GO:0009143 nucleoside triphosphate catabolic process;GO:0009217 purine deoxyribonucleoside triphosphate catabolic process;GO:0009213 pyrimidine deoxyribonucleoside triphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P47119-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47122-1", "uniprot_id": [ { "id": "GPN1_YEAST", "url": "https://www.uniprot.org/uniprot/P47122", "type": "external" } ], "mass": 43195.0, "length": 385, "protein_name": "GPN-loop GTPase 1", "gene_name": "NPA3", "organism": "Yeast", "refseq_name": "GTPase NPA3", "refseq_ac": [ { "id": "NP_012606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012606", "type": "external" } ], "gene_names_uniprotkb": "NPA3; EPA1; GPN1; J1821", "gene_names_refseq": "EPA1; GPN1; NPA3", "protein_names_uniprotkb": "GPN-loop GTPase 1; 3.6.5.-; Essential PCL1-interacting ATPase 1; GPN-loop GTPase NPA3; Nucleolar preribosomal-associated protein 3", "protein_names_refseq": "GTPase NPA3", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR072C)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "14562095;14562106;15082539;15226434;17563356;18407956;19779198;20702584;20855544;21126336;21532343;21844196;22106047;23267056;23324351;23749301;24374639;26711263;32597660;33481703;33491328;8641269;8840504", "class_list": "", "function": "Small GTPase involved in the correct assembly of RNA polymerase II (RNAPII) complex, ensuring proper nuclear import of RNAPII (PubMed:20855544, PubMed:21844196, PubMed:23267056, PubMed:26711263). In vitro, exhibits a chaperone-like activity and a chaperone substrate protein can stimulate its GTPase activity (PubMed:26711263). It is proposed to bind exposed hydrophobic peptide regions of newly synthesized RNAP II subunit, triggering the opening of a hydrophobic pocket in its GDP-bound state (Probable). This interaction likely traps exposed hydrophobic regions, preventing misassembly and providing a time window for association with the cognate RNAP II subunit (Probable). Peptide binding promotes GDP release, and increasing GTP affinity to facilitate GTP rebinding (Probable). Subsequent GTP hydrolysis would then lead to the release of the bound RNAP II subunit to enable association with cognate subunits and RNAP II assembly (Probable). Promotes sister chromatid separation during anaphase (PubMed:21532343)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWP2", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0007064 mitotic sister chromatid cohesion;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P47122-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47128-1", "uniprot_id": [ { "id": "EAF6_YEAST", "url": "https://www.uniprot.org/uniprot/P47128", "type": "external" } ], "mass": 12895.0, "length": 113, "protein_name": "Chromatin modification-related protein EAF6", "gene_name": "EAF6", "organism": "Yeast", "refseq_name": "Eaf6p", "refseq_ac": [ { "id": "NP_012615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012615", "type": "external" } ], "gene_names_uniprotkb": "EAF6; J1854", "gene_names_refseq": "EAF6", "protein_names_uniprotkb": "Chromatin modification-related protein EAF6; ESA1-associated factor 6", "protein_names_refseq": "Eaf6p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR082C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562095;14562106;15353583;15485911;17157260;17322287;24374639;25104842;27594449;33481703;33491328;36198799;8641269;8840504", "class_list": "", "function": "Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (PubMed:15485911, PubMed:15353583). Component of the NuA3 histone acetyltransferase complex. The NuA3 HAT complex has 2 functionally distinct forms. NuA3a binds H3K4me3, through the PHD finger of YNG1, and acetylates H3K14 at the promoter region of actively transcribed genes to promote transcription initiation. NuA3b binds H3K36me3 at the coding regions of actively transcribed genes, through the PWWP domain of PDP3, and coordinates transcription elongation (PubMed:17157260, PubMed:25104842)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWQ1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0035267 NuA4 histone acetyltransferase complex;GO:1990467 NuA3a histone acetyltransferase complex;GO:1990468 NuA3b histone acetyltransferase complex;GO:0033100 NuA3 histone acetyltransferase complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P47128-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47134-1", "uniprot_id": [ { "id": "BIR1_YEAST", "url": "https://www.uniprot.org/uniprot/P47134", "type": "external" } ], "mass": 108667.0, "length": 954, "protein_name": "Chromosomal passenger complex protein BIR1", "gene_name": "BIR1", "organism": "Yeast", "refseq_name": "survivin", "refseq_ac": [ { "id": "NP_012622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012622", "type": "external" } ], "gene_names_uniprotkb": "BIR1; J1880", "gene_names_refseq": "BIR1", "protein_names_uniprotkb": "Chromosomal passenger complex protein BIR1", "protein_names_refseq": "survivin", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR089W)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10468581;10557299;10702224;15665377;16381814;17287358;17563356;18407956;19779198;19795423;19823750;20190278;20702584;21126336;21177495;21725298;23749301;24374639;32597660;33481703;33491328;33502312;34965436;8641269;8840504", "class_list": "", "function": "Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 71, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWQ7", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005819 spindle;GO:0005874 microtubule", "go_biological_process": "GO:0007059 chromosome segregation;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0000281 mitotic cytokinesis;GO:0007094 mitotic spindle assembly checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P47134-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47142-1", "uniprot_id": [ { "id": "VPS25_YEAST", "url": "https://www.uniprot.org/uniprot/P47142", "type": "external" } ], "mass": 23558.0, "length": 202, "protein_name": "Vacuolar protein-sorting-associated protein 25", "gene_name": "VPS25", "organism": "Yeast", "refseq_name": "ESCRT-II subunit protein VPS25", "refseq_ac": [ { "id": "NP_012636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012636", "type": "external" } ], "gene_names_uniprotkb": "VPS25; J1957; VPT25", "gene_names_refseq": "VPL12; VPS25; VPT25", "protein_names_uniprotkb": "Vacuolar protein-sorting-associated protein 25; ESCRT-II complex subunit VPS25", "protein_names_refseq": "ESCRT-II subunit protein VPS25", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305)", "pathway": " (sce:YJR102C); (R-SCE-917729)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12194858;15329733;15469844;15579210;24374639;8641269", "class_list": "", "function": "Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWS1", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0000814 ESCRT II complex;GO:0005829 cytosol", "go_biological_process": "GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006623 protein targeting to vacuole;GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:1904669 ATP export", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P47142-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47143-1", "uniprot_id": [ { "id": "ADK_YEAST", "url": "https://www.uniprot.org/uniprot/P47143", "type": "external" } ], "mass": 36372.0, "length": 340, "protein_name": "Adenosine kinase", "gene_name": "ADO1", "organism": "Yeast", "refseq_name": "adenosine kinase", "refseq_ac": [ { "id": "NP_012639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012639", "type": "external" } ], "gene_names_uniprotkb": "ADO1; J1973", "gene_names_refseq": "ADO1", "protein_names_uniprotkb": "Adenosine kinase; 2.7.1.20", "protein_names_refseq": "adenosine kinase", "tax_id": 559292, "disease": "hypermethioninemia due to adenosine kinase deficiency (Disease Ontology:DOID:0111038); temporal lobe epilepsy (Disease Ontology:DOID:3328); brain infarction (Disease Ontology:DOID:3454); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (sce:YJR105W); (R-SCE-74217); (R-SCE-9755088)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11223943;14558146;14562106;17322287;23749301;24374639;33481703;33491328;8641269", "class_list": "", "function": "ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. ADO1 does not play a major role in adenine utilization in yeast. Its physiological role could primarily be to recycle adenosine produced by the methyl cycle., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWS4", "ec_number_list": [ { "id": "2.7.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.20", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004001 adenosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0044209 AMP salvage;GO:0006166 purine ribonucleoside salvage;GO:0006144 purine nucleobase metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P47143-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47154-1", "uniprot_id": [ { "id": "STE24_YEAST", "url": "https://www.uniprot.org/uniprot/P47154", "type": "external" } ], "mass": 52324.0, "length": 453, "protein_name": "CAAX prenyl protease 1", "gene_name": "STE24", "organism": "Yeast", "refseq_name": "zinc metalloprotease", "refseq_ac": [ { "id": "NP_012651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012651", "type": "external" } ], "gene_names_uniprotkb": "STE24; AFC1; J2032", "gene_names_refseq": "AFC1; PIO2; STE24", "protein_names_uniprotkb": "CAAX prenyl protease 1; 3.4.24.84; A-factor-converting enzyme; PPSEP 1; Prenyl protein-specific endoprotease 1", "protein_names_refseq": "zinc metalloprotease", "tax_id": 559292, "disease": "familial partial lipodystrophy (Disease Ontology:DOID:0050440); restrictive dermopathy (Disease Ontology:DOID:0060762); restrictive dermopathy 1 (Disease Ontology:DOID:0070369); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); mandibuloacral dysplasia type B lipodystrophy (Disease Ontology:DOID:0081129); Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726); progeria (Disease Ontology:DOID:3911); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YJR117W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10692417;10825201;11581258;14562106;16847258;18923140;24374639;26771486;27129777;32513868;33491328;8641269;9015299;9065405;9700155;9725832;9736709", "class_list": "", "function": "Protease involved in the processing of a variety of prenylated proteins containing the C-terminal CAAX motif, where C is a cysteine modified with an isoprenoid lipid, A is an aliphatic amino acid and X is any C-terminal amino acid. Can cleave both isoprenylated and non-prenylated substrates in vitro (PubMed:27129777). Proteolytically removes the C-terminal three residues of farnesylated a-factor mating pheromone. Also acts to cleave the N-terminal extension of the pheromone. Does not act on Ras. Its substrate specificity is overlapping but distinct with that of RCE1 (PubMed:10692417, PubMed:10825201, PubMed:9015299, PubMed:9065405, PubMed:9700155, PubMed:9725832). Involved in quality control mechanisms during protein translocation into the endoplasmic reticulum (ER) (PubMed:26771486, PubMed:32513868). In the biogenesis of endomembrane proteins, resolves clogged translocons resulting from faulty translocation. Approaches the translocon upon clogging, and interacts with and generates cleavage fragments of the clogged protein (PubMed:26771486). Suppresses the translocation proteins devoid of a signal peptide (PubMed:32513868)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWT6", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0071586 CAAX-box protein processing;GO:0016485 protein processing;GO:0036503 ERAD pathway;GO:0019236 response to pheromone;GO:0031204 post-translational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P47154-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47156-1", "uniprot_id": [ { "id": "JHD2_YEAST", "url": "https://www.uniprot.org/uniprot/P47156", "type": "external" } ], "mass": 84984.0, "length": 728, "protein_name": "Histone demethylase JHD2", "gene_name": "JHD2", "organism": "Yeast", "refseq_name": "histone demethylase", "refseq_ac": [ { "id": "NP_012653", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012653", "type": "external" } ], "gene_names_uniprotkb": "JHD2; J2035", "gene_names_refseq": "JHD2; KDM5", "protein_names_uniprotkb": "Histone demethylase JHD2; 1.14.11.67; Jumonji/ARID domain-containing protein 2; [histone H3]-trimethyl-L-lysine(4) demethylase JHD2", "protein_names_refseq": "histone demethylase", "tax_id": 559292, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); autism spectrum disorder (Disease Ontology:DOID:0060041); syndromic X-linked intellectual disability Claes-Jensen type (Disease Ontology:DOID:0060809); autosomal recessive intellectual developmental disorder 65 (Disease Ontology:DOID:0081226); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); intellectual disability (Disease Ontology:DOID:1059); urinary bladder cancer (Disease Ontology:DOID:11054); cryptorchidism (Disease Ontology:DOID:11383); descending colon cancer (Disease Ontology:DOID:12190); Huntington's disease (Disease Ontology:DOID:12858); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); high grade glioma (Disease Ontology:DOID:3070); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); schizophrenia (Disease Ontology:DOID:5419); stomach carcinoma (Disease Ontology:DOID:5517); uveal melanoma (Disease Ontology:DOID:6039); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); colorectal cancer (Disease Ontology:DOID:9256); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (sce:YJR119C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;17310255;24374639;33334889;33491328;35183557;36167807;8641269", "class_list": "", "function": "Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated H3 'Lys-4'., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWT8", "ec_number_list": [ { "id": "1.14.11.67", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.67", "type": "external" } ], "go_molecular_function": "GO:0034647 histone H3K4me/H3K4me2/H3K4me3 demethylase activity;GO:0032453 histone H3K4 demethylase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P47156-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47158-1", "uniprot_id": [ { "id": "CAF17_YEAST", "url": "https://www.uniprot.org/uniprot/P47158", "type": "external" } ], "mass": 57055.0, "length": 497, "protein_name": "Iron-sulfur cluster assembly factor IBA57, mitochondrial", "gene_name": "IBA57", "organism": "Yeast", "refseq_name": "Iba57p", "refseq_ac": [ { "id": "NP_012656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012656", "type": "external" } ], "gene_names_uniprotkb": "IBA57; CAF17; J2043", "gene_names_refseq": "CAF17; IBA57", "protein_names_uniprotkb": "Iron-sulfur cluster assembly factor IBA57, mitochondrial; 57 kDa iron-sulfur cluster assembly factor for biotin synthase- and aconitase-like mitochondrial proteins; CCR4-associated factor 17", "protein_names_refseq": "Iba57p", "tax_id": 559292, "disease": "multiple mitochondrial dysfunctions syndrome 3 (Disease Ontology:DOID:0080135); hereditary spastic paraplegia 74 (Disease Ontology:DOID:0110819)", "pathway": " (sce:YJR122W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12161108;14562095;14562106;14734555;16823961;18086897;24374639;8641269", "class_list": "", "function": "Required for lysine and glutamate prototrophy and mitochondrial genome maintenance. Has a role in the maturation of mitochondrial aconitase-type and radical-SAM Fe/S proteins biotin synthase and lipoic acid synthase., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VWU1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P47158-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47160-1", "uniprot_id": [ { "id": "ENT3_YEAST", "url": "https://www.uniprot.org/uniprot/P47160", "type": "external" } ], "mass": 45091.0, "length": 408, "protein_name": "Epsin-3", "gene_name": "ENT3", "organism": "Yeast", "refseq_name": "Ent3p", "refseq_ac": [ { "id": "NP_012659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012659", "type": "external" } ], "gene_names_uniprotkb": "ENT3; J2048", "gene_names_refseq": "ENT3", "protein_names_uniprotkb": "Epsin-3", "protein_names_refseq": "Ent3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR125C); (R-SCE-8856825)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "12483220;15107463;15665377;17322287;17330950;18407956;19684113;19779198;19795423;19823750;21126336;21177495;22218487;22814378;23749301;24374639;27821475;28270554;31208443;32597660;33481703;33491328;8641269", "class_list": "", "function": "Involved in the recruitment of clathrin to the Golgi network and endosomes to form clathrin coated vesicles. Plays a role in the trafficking of clathrin between the Golgi network and endosomes. Binds to membranes enriched in phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) and, in association with VPS27, is involved in protein sorting at the multivesicular body (MVB)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 30, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWU4", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0030276 clathrin binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0071985 multivesicular body sorting pathway;GO:0006897 endocytosis;GO:0015031 protein transport;GO:0030036 actin cytoskeleton organization;GO:0006895 Golgi to endosome transport", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P47160-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47164-1", "uniprot_id": [ { "id": "MET7_YEAST", "url": "https://www.uniprot.org/uniprot/P47164", "type": "external" } ], "mass": 72351.0, "length": 639, "protein_name": "Cystathionine gamma-synthase", "gene_name": "STR2", "organism": "Yeast", "refseq_name": "cystathionine gamma-synthase", "refseq_ac": [ { "id": "NP_012664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012664", "type": "external" } ], "gene_names_uniprotkb": "STR2; J2063", "gene_names_refseq": "STR2", "protein_names_uniprotkb": "Cystathionine gamma-synthase; 2.5.1.48; O-succinylhomoserine (thiol)-lyase; Sulfur transfer protein 2", "protein_names_refseq": "cystathionine gamma-synthase", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR130C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10821189;14562095;14562106;17322287;19795423;19823750;24374639;33229814;8641269", "class_list": "", "function": "Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VWU8", "ec_number_list": [ { "id": "2.5.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.48", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0003962 cystathionine gamma-synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006790 sulfur compound metabolic process;GO:0009086 methionine biosynthetic process;GO:0019346 transsulfuration", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P47164-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47168-1", "uniprot_id": [ { "id": "TTI2_YEAST", "url": "https://www.uniprot.org/uniprot/P47168", "type": "external" } ], "mass": 48649.0, "length": 421, "protein_name": "TEL2-interacting protein 2", "gene_name": "TTI2", "organism": "Yeast", "refseq_name": "Tti2p", "refseq_ac": [ { "id": "NP_012670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012670", "type": "external" } ], "gene_names_uniprotkb": "TTI2; J2124", "gene_names_refseq": "TTI2", "protein_names_uniprotkb": "TEL2-interacting protein 2", "protein_names_refseq": "Tti2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR136C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;14562106;14690591;17322287;19040720;19795423;19823750;20801936;22814378;24374639;8641269", "class_list": "", "function": "Component of the ASTRA complex probably in chromatin remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWV5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0110078 TTT Hsp90 cochaperone complex", "go_biological_process": "GO:0034605 cellular response to heat;GO:0006974 DNA damage response;GO:0050821 protein stabilization;GO:0031669 cellular response to nutrient levels;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P47168-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47169-1", "uniprot_id": [ { "id": "MET5_YEAST", "url": "https://www.uniprot.org/uniprot/P47169", "type": "external" } ], "mass": 161219.0, "length": 1442, "protein_name": "Sulfite reductase [NADPH] subunit beta", "gene_name": "MET5", "organism": "Yeast", "refseq_name": "sulfite reductase (NADPH) subunit beta", "refseq_ac": [ { "id": "NP_116579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116579", "type": "external" } ], "gene_names_uniprotkb": "MET5; ECM17; J2126", "gene_names_refseq": "ECM17; MET5", "protein_names_uniprotkb": "Sulfite reductase [NADPH] subunit beta; 1.8.1.2; Extracellular mutant protein 17", "protein_names_refseq": "sulfite reductase (NADPH) subunit beta", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR137C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;14562106;18407956;19779198;24374639;33481703;33491328;6751400;8641269;8962070;9335584", "class_list": "", "function": "Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWV6", "ec_number_list": [ { "id": "1.8.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0020037 heme binding;GO:0010181 FMN binding;GO:0004783 sulfite reductase (NADPH) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0071944 cell periphery;GO:0010494 cytoplasmic stress granule;GO:0009337 sulfite reductase complex (NADPH);GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0000097 sulfur amino acid biosynthetic process;GO:0070814 hydrogen sulfide biosynthetic process;GO:0000103 sulfate assimilation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P47169-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47170-1", "uniprot_id": [ { "id": "IML1_YEAST", "url": "https://www.uniprot.org/uniprot/P47170", "type": "external" } ], "mass": 181949.0, "length": 1584, "protein_name": "Vacuolar membrane-associated protein IML1", "gene_name": "IML1", "organism": "Yeast", "refseq_name": "GTPase-activating protein IML1", "refseq_ac": [ { "id": "NP_012672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012672", "type": "external" } ], "gene_names_uniprotkb": "IML1; J2129; SEA1", "gene_names_refseq": "IML1; SEA1", "protein_names_uniprotkb": "Vacuolar membrane-associated protein IML1; Increased minichromosome loss protein 1; SEH-associated protein 1", "protein_names_refseq": "GTPase-activating protein IML1", "tax_id": 559292, "disease": "familial focal epilepsy with variable foci 1 (Disease Ontology:DOID:0081421); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); cancer (Disease Ontology:DOID:162); epilepsy (Disease Ontology:DOID:1826); focal epilepsy (Disease Ontology:DOID:2234)", "pathway": " (sce:YJR138W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "14562095;14562106;17287358;17330950;18407956;19779198;20489023;20702584;21177495;21454883;22218487;23749301;24374639;32597660;33229814;33481703;33491328;8641269", "class_list": "", "function": "Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VWV7", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005774 vacuolar membrane;GO:1990130 GATOR1 complex;GO:0000329 fungal-type vacuole membrane;GO:0035859 Seh1-associated complex", "go_biological_process": "GO:0015031 protein transport;GO:0035556 intracellular signal transduction;GO:0051058 negative regulation of small GTPase mediated signal transduction;GO:0034599 cellular response to oxidative stress;GO:0010508 positive regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P47170-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47171-1", "uniprot_id": [ { "id": "HIR3_YEAST", "url": "https://www.uniprot.org/uniprot/P47171", "type": "external" } ], "mass": 191680.0, "length": 1648, "protein_name": "Histone transcription regulator 3", "gene_name": "HIR3", "organism": "Yeast", "refseq_name": "Hir3p", "refseq_ac": [ { "id": "NP_012674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012674", "type": "external" } ], "gene_names_uniprotkb": "HIR3; HPC1; J2161", "gene_names_refseq": "HIR3; HPC1", "protein_names_uniprotkb": "Histone transcription regulator 3", "protein_names_refseq": "Hir3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR140C); (R-SCE-2559584)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "12524332;14562106;16264190;16303565;18407956;19683497;19779198;24374639;33481703;33491328;8641269;9001207;9671488", "class_list": "", "function": "HIR1, HIR2 and HIR3 are repressors of histone gene transcription. They are required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. Also has a role in nucleosome assembly., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWV9", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0000417 HIR complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:0000082 G1/S transition of mitotic cell cycle;GO:0006334 nucleosome assembly;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P47171-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47176-1", "uniprot_id": [ { "id": "BCA2_YEAST", "url": "https://www.uniprot.org/uniprot/P47176", "type": "external" } ], "mass": 41625.0, "length": 376, "protein_name": "Branched-chain-amino-acid aminotransferase, cytosolic", "gene_name": "BAT2", "organism": "Yeast", "refseq_name": "branched-chain-amino-acid transaminase BAT2", "refseq_ac": [ { "id": "NP_012682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012682", "type": "external" } ], "gene_names_uniprotkb": "BAT2; ECA40; J2209; TWT2", "gene_names_refseq": "BAT2; ECA40; TWT2", "protein_names_uniprotkb": "Branched-chain-amino-acid aminotransferase, cytosolic; 2.6.1.42; BCAT; Protein TWT2", "protein_names_refseq": "branched-chain-amino-acid transaminase BAT2", "tax_id": 559292, "disease": "hypervalinemia and hyperleucine-isoleucinemia (Disease Ontology:DOID:0060950); amino acid metabolic disorder (Disease Ontology:DOID:9252); maple syrup urine disease (Disease Ontology:DOID:9269)", "pathway": " (sce:YJR148W); (R-SCE-70895)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "14562106;18407956;18625006;21267457;24374639;28912343;29037781;33229814;33491328;8641269;8702755;8798704", "class_list": "", "function": "Cytoplasmic isozyme of branched-chain-amino-acid aminotransferase, which catalyzes the first reaction in the catabolism of the essential branched chain amino acids (BCAAs) leucine, isoleucine, and valine (PubMed:21267457, PubMed:8702755, PubMed:8798704). Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using BCAAs (leucine, isoleucine, and valine) as well as lysine and proline as the amino donors (PubMed:18625006). Involved in cell cycle regulation (Probable)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VWW6;Q07124", "ec_number_list": [ { "id": "2.6.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.42", "type": "external" } ], "go_molecular_function": "GO:0004084 branched-chain-amino-acid transaminase activity;GO:0052654 L-leucine-2-oxoglutarate transaminase activity;GO:0052655 L-valine-2-oxoglutarate transaminase activity;GO:0052656 L-isoleucine-2-oxoglutarate transaminase activity;GO:0010326 methionine-oxo-acid transaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0009083 branched-chain amino acid catabolic process;GO:0019509 L-methionine salvage from methylthioadenosine;GO:0009082 branched-chain amino acid biosynthetic process;GO:0009098 L-leucine biosynthetic process;GO:0009099 L-valine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P47176-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47178-1", "uniprot_id": [ { "id": "DAN1_YEAST", "url": "https://www.uniprot.org/uniprot/P47178", "type": "external" } ], "mass": 29606.0, "length": 298, "protein_name": "Cell wall protein DAN1", "gene_name": "DAN1", "organism": "Yeast", "refseq_name": "Dan1p", "refseq_ac": [ { "id": "NP_012684", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012684", "type": "external" } ], "gene_names_uniprotkb": "DAN1; CCW13; J2217", "gene_names_refseq": "CCW13; DAN1", "protein_names_uniprotkb": "Cell wall protein DAN1; Covalently-linked cell wall protein 13; Delayed anaerobic protein 1", "protein_names_refseq": "Dan1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR150C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10322008;11292809;24374639;8641269;9224891", "class_list": "", "function": "Component of the cell wall., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWW8;O94102", "ec_number_list": [], "go_molecular_function": "GO:0005199 structural constituent of cell wall", "go_cellular_component": "GO:0071944 cell periphery;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0015918 sterol transport;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P47178-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47818-1", "uniprot_id": [ { "id": "CCC1_YEAST", "url": "https://www.uniprot.org/uniprot/P47818", "type": "external" } ], "mass": 34250.0, "length": 322, "protein_name": "Protein CCC1", "gene_name": "CCC1", "organism": "Yeast", "refseq_name": "Ccc1p", "refseq_ac": [ { "id": "NP_013321", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013321", "type": "external" } ], "gene_names_uniprotkb": "CCC1; L8083.6", "gene_names_refseq": "CCC1", "protein_names_uniprotkb": "Protein CCC1; Cross-complementer of CSG1 protein 1", "protein_names_refseq": "Ccc1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR220W)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "10713071;11390404;11875433;14562095;14562106;15161905;15652485;16847258;17322287;17330950;17563356;17603109;18070921;18407956;19684113;19779198;20702584;21126336;22218487;23749301;24374639;30516470;32597660;33481703;33491328;7941738;8668190;8866476;9169871", "class_list": "", "function": "Has a role in both calcium and manganese homeostasis. Involved in the transfer of iron and Mn(2+) from the cytosol to the vacuole for storage of these metals., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYM0", "ec_number_list": [], "go_molecular_function": "GO:0005384 manganese ion transmembrane transporter activity;GO:0015093 ferrous iron transmembrane transporter activity;GO:0005381 iron ion transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0006879 intracellular iron ion homeostasis;GO:0006826 iron ion transport;GO:0006828 manganese ion transport;GO:0030026 intracellular manganese ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P47818-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47821-1", "uniprot_id": [ { "id": "SSN8_YEAST", "url": "https://www.uniprot.org/uniprot/P47821", "type": "external" } ], "mass": 37791.0, "length": 323, "protein_name": "RNA polymerase II holoenzyme cyclin-like subunit", "gene_name": "SSN8", "organism": "Yeast", "refseq_name": "cyclin-dependent protein serine/threonine kinase regulator SSN8", "refseq_ac": [ { "id": "NP_014373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014373", "type": "external" } ], "gene_names_uniprotkb": "SSN8; GIG3; N2805; NUT9; SRB11; UME3", "gene_names_refseq": "CNC1; GIG3; NUT9; RYE2; SRB11; SSN8; UME3", "protein_names_uniprotkb": "RNA polymerase II holoenzyme cyclin-like subunit; Suppressor of RNA polymerase B 11", "protein_names_refseq": "cyclin-dependent protein serine/threonine kinase regulator SSN8", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL025C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11226276;11555651;12200444;12520306;14555478;15477388;15601835;15687503;16076843;16109375;16630888;18407956;24374639;24554767;33933450;7732022;7877695;9169873;9702190", "class_list": "", "function": "Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II RPB1 at serines 2 and 5. The SSN3/SRB10 and SSN8/SRB11 kinase-cyclin pair may also positively and negatively regulate numerous transcriptional activators in response to changes in nutritional and physiological conditions., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1F3", "ec_number_list": [], "go_molecular_function": "GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P47821-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47822-1", "uniprot_id": [ { "id": "MED21_YEAST", "url": "https://www.uniprot.org/uniprot/P47822", "type": "external" } ], "mass": 16071.0, "length": 140, "protein_name": "Mediator of RNA polymerase II transcription subunit 21", "gene_name": "SRB7", "organism": "Yeast", "refseq_name": "Srb7p", "refseq_ac": [ { "id": "NP_010594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010594", "type": "external" } ], "gene_names_uniprotkb": "SRB7; D9740.17; MED21", "gene_names_refseq": "MED21; SRB7; SSX1", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 21; Mediator complex subunit 21; RNAPII complex component SRB7; Suppressor of RNA polymerase B 7", "protein_names_refseq": "Srb7p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR308C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11555651;12191485;14562095;14562106;15175151;15477388;15710619;16002404;16076843;16263706;17192271;17322287;19795423;19823750;24374639;7774808;9169867", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VST7", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity;GO:0003712 transcription coregulator activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P47822-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47912-1", "uniprot_id": [ { "id": "LCF4_YEAST", "url": "https://www.uniprot.org/uniprot/P47912", "type": "external" } ], "mass": 77267.0, "length": 694, "protein_name": "Long-chain-fatty-acid--CoA ligase 4", "gene_name": "FAA4", "organism": "Yeast", "refseq_name": "long-chain fatty acid-CoA ligase FAA4", "refseq_ac": [ { "id": "NP_013974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013974", "type": "external" } ], "gene_names_uniprotkb": "FAA4; YM9408.08", "gene_names_refseq": "FAA4", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase 4; 6.2.1.3; FACS; Fatty acid activator 4; Fatty acyl-CoA synthetase; Long-chain acyl-CoA synthetase 4", "protein_names_refseq": "long-chain fatty acid-CoA ligase FAA4", "tax_id": 559292, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); non-syndromic X-linked intellectual disability 63 (Disease Ontology:DOID:0112050); prostate cancer (Disease Ontology:DOID:10283); intellectual disability (Disease Ontology:DOID:1059); lung cancer (Disease Ontology:DOID:1324); Sjogren-Larsson syndrome (Disease Ontology:DOID:14501); breast cancer (Disease Ontology:DOID:1612); asthma (Disease Ontology:DOID:2841)", "pathway": " (sce:YMR246W); (R-SCE-434313); (R-SCE-75876)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "11477098;12601005;14562106;21820081;22633490;22814378;24269233;24374639;24868093;27136724;32597660;33481703;33491328;7962057;9169872", "class_list": "", "function": "Activates long-chain fatty acids (LCFA) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. Also facilitates the transport of LCFAs into the cell, either by active transport or by decreasing the intracellular LCFA concentration (PubMed:11477098, PubMed:12601005, PubMed:7962057). Contributes, with FAA1, to the activation of imported myristate (PubMed:7962057). Also involved in long-chain base (LCB) uptake. In contrast ot LCFA uptake, LCB uptake does not require ATP, suggesting that the enzyme is directly involved in LCB uptake (PubMed:27136724). Involved in the sphingolipid-to-glycerolipid metabolic pathway, converting the sphingolipid metabolite hexadecenoic acid to hexadecenoyl-CoA, which is then further converted to glycerolipids (PubMed:22633490)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W073;Q05743", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0044539 long-chain fatty acid import into cell;GO:0035336 long-chain fatty-acyl-CoA metabolic process;GO:1905329 sphingoid long-chain base transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P47912-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47977-1", "uniprot_id": [ { "id": "CTH2_YEAST", "url": "https://www.uniprot.org/uniprot/P47977", "type": "external" } ], "mass": 32314.0, "length": 285, "protein_name": "mRNA decay factor CTH2", "gene_name": "TIS11", "organism": "Yeast", "refseq_name": "Tis11p", "refseq_ac": [ { "id": "NP_013237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013237", "type": "external" } ], "gene_names_uniprotkb": "TIS11; CTH2; L3143; L9606.12", "gene_names_refseq": "CTH2; TIS11", "protein_names_uniprotkb": "mRNA decay factor CTH2; Cysteine-three-histidine protein 2; Protein TIS11 homolog; Protein YTIS11; TPA-induced sequence protein 11", "protein_names_refseq": "Tis11p", "tax_id": 559292, "disease": "breast cancer (Disease Ontology:DOID:1612); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (sce:YLR136C); (R-SCE-450513)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "14562095;15652485;17322287;18522836;18715869;18923425;24374639;30228242;33481703;7845673;8890739;9169871", "class_list": "", "function": "Binds to specific AU-rich elements (ARE) in the 3'-untranslated region of target mRNAs and promotes their degradation. In response to iron deficiency, promotes the decay of many mRNAs encoding proteins involved in iron-dependent pathways. Recruits the DHH1 helicase to the SDH4 mRNA and promotes SDH4 mRNA decay. Also destabilizes target mRNA by modulating 3'-end processing, creating extended transcripts that are prone for degradation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYD1", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0030371 translation repressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0000932 P-body", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:2000766 negative regulation of cytoplasmic translation;GO:0015990 electron transport coupled proton transport;GO:0070130 negative regulation of mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P47977-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48016-1", "uniprot_id": [ { "id": "ATH1_YEAST", "url": "https://www.uniprot.org/uniprot/P48016", "type": "external" } ], "mass": 136921.0, "length": 1211, "protein_name": "Periplasmic acid trehalase ATH1", "gene_name": "ATH1", "organism": "Yeast", "refseq_name": "alpha,alpha-trehalase ATH1", "refseq_ac": [ { "id": "NP_015351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015351", "type": "external" } ], "gene_names_uniprotkb": "ATH1; YP9367.06", "gene_names_refseq": "ATH1", "protein_names_uniprotkb": "Periplasmic acid trehalase ATH1; 3.2.1.28; Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase", "protein_names_refseq": "alpha,alpha-trehalase ATH1", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR026W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17475771;19703229;21177495;24374639;33491328;7502577;8647289;8764988;9169875", "class_list": "glycogene;glycosylhydrolase", "function": "Periplasmic acid trehalase that catalyzes hydrolysis of the disaccharide trehalose and required for growth on trehalose as carbon source (PubMed:19703229, PubMed:7502577, PubMed:8647289, PubMed:8764988). Growth on trehalose is strictly respiratory (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 26, "predicted_n_glycosites": 26, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 26, "binding_glycan_count": 0, "secondary_ac_list": "D6W436", "ec_number_list": [ { "id": "3.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.28", "type": "external" } ], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0004555 alpha,alpha-trehalase activity", "go_cellular_component": "GO:0016020 membrane;GO:0071944 cell periphery;GO:0000324 fungal-type vacuole;GO:0000328 fungal-type vacuole lumen;GO:0009277 fungal-type cell wall", "go_biological_process": "GO:0005993 trehalose catabolic process;GO:0015771 trehalose transport;GO:0015976 carbon utilization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P48016-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0000000010001.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48164-1", "uniprot_id": [ { "id": "RS7B_YEAST", "url": "https://www.uniprot.org/uniprot/P48164", "type": "external" } ], "mass": 21634.0, "length": 190, "protein_name": "Small ribosomal subunit protein eS7B", "gene_name": "RPS7B", "organism": "Yeast", "refseq_name": "40S ribosomal protein eS7 RPS7B", "refseq_ac": [ { "id": "NP_014303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014303", "type": "external" } ], "gene_names_uniprotkb": "RPS7B; N2212", "gene_names_refseq": "RPS7B", "protein_names_uniprotkb": "Small ribosomal subunit protein eS7B; 40S ribosomal protein S7-B", "protein_names_refseq": "40S ribosomal protein eS7 RPS7B", "tax_id": 559292, "disease": "Diamond-Blackfan anemia 8 (Disease Ontology:DOID:0111881)", "pathway": " (sce:YNL096C)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10601260;14562095;14562106;15590835;15665377;17287358;17330950;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22096102;23749301;24374639;24524803;27821475;30377154;30609991;32597660;33481703;33491328;8771715;9169873;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eS7 is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (PubMed:15590835)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W184", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0042254 ribosome biogenesis;GO:0006364 rRNA processing;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P48164-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48231-1", "uniprot_id": [ { "id": "TCB2_YEAST", "url": "https://www.uniprot.org/uniprot/P48231", "type": "external" } ], "mass": 132509.0, "length": 1178, "protein_name": "Tricalbin-2", "gene_name": "TCB2", "organism": "Yeast", "refseq_name": "tricalbin", "refseq_ac": [ { "id": "NP_014312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014312", "type": "external" } ], "gene_names_uniprotkb": "TCB2; N2250", "gene_names_refseq": "TCB2", "protein_names_uniprotkb": "Tricalbin-2", "protein_names_refseq": "tricalbin", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL087W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562095;14562106;15049706;15141306;16273108;18407956;21177495;22250200;23749301;24374639;32597660;33481703;33491328;8740422;9169873", "class_list": "", "function": "May play a role in membrane trafficking., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W192;Q45TY9", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0071944 cell periphery;GO:0032541 cortical endoplasmic reticulum", "go_biological_process": "GO:0090158 endoplasmic reticulum membrane organization;GO:0055091 phospholipid homeostasis;GO:0060304 regulation of phosphatidylinositol dephosphorylation;GO:0035621 ER to Golgi ceramide transport;GO:0061817 endoplasmic reticulum-plasma membrane tethering", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P48231-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48236-1", "uniprot_id": [ { "id": "GPC1_YEAST", "url": "https://www.uniprot.org/uniprot/P48236", "type": "external" } ], "mass": 51647.0, "length": 432, "protein_name": "Glycerophosphocholine acyltransferase 1", "gene_name": "GPC1", "organism": "Yeast", "refseq_name": "glycerophosphocholine acyltransferase", "refseq_ac": [ { "id": "NP_011665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011665", "type": "external" } ], "gene_names_uniprotkb": "GPC1; G6639", "gene_names_refseq": "GPC1", "protein_names_uniprotkb": "Glycerophosphocholine acyltransferase 1; 2.3.1.-; GPCAT", "protein_names_refseq": "glycerophosphocholine acyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR149W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "12524434;16847258;17330950;17563356;18407956;18430972;19779198;21126336;23749301;24374639;27758859;30514764;33481703;33491328;8585325;9169869", "class_list": "", "function": "Glycerophosphocholine acyltransferase (GPCAT) that utilizes acyl-CoA to acylate glycero-3-phosphocholine (GPC), forming lysophosphatidylcholine (LPC) (PubMed:18430972, PubMed:27758859). Shows broad acyl specificities with a preference for 16:0-CoA, polyunsaturated acyl-CoA, and the hydroxylated ricinoleoyl-CoA (PubMed:18430972, PubMed:27758859). Also catalyzes the acylation of glycero-3-phosphoethanolamine (GPE) with acyl-CoA (PubMed:27758859). In addition to acyl-CoA, GPCAT efficiently utilizes LPC and lysophosphatidylethanolamine (LPE) as acyl donors in the acylation of GPC (PubMed:27758859). Contributes to the maintenance of phosphatidylcholine (PC) homeostasis and might also have specific functions in acyl editing of PC, such as transferring acyl groups modified at the sn-2 position of PC to the sn-1 (PubMed:27758859). Involved in postsynthetic PC remodeling that produces more saturated PC species (PubMed:30514764)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUT0", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0106158 glycero-3-phosphocholine acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0006656 phosphatidylcholine biosynthetic process;GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:0090640 phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P48236-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48237-1", "uniprot_id": [ { "id": "CCM1_YEAST", "url": "https://www.uniprot.org/uniprot/P48237", "type": "external" } ], "mass": 101423.0, "length": 864, "protein_name": "Mitochondrial 15S rRNA processing factor CCM1", "gene_name": "CCM1", "organism": "Yeast", "refseq_name": "Ccm1p", "refseq_ac": [ { "id": "NP_011666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011666", "type": "external" } ], "gene_names_uniprotkb": "CCM1; DMR1; G6642; RRG2", "gene_names_refseq": "CCM1; DMR1; RRG2", "protein_names_uniprotkb": "Mitochondrial 15S rRNA processing factor CCM1; COB and COX1 mRNA maturation protein 1; Degradation of mitochondrial rRNA protein 1; Required for respiratory growth protein 2", "protein_names_refseq": "Ccm1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR150C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562095;14562106;16823961;19562342;19751518;20124025;21546354;22861139;24374639;27920033;32152734;32467310;36482135;8585325;9169869", "class_list": "", "function": "Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing (PubMed:22861139, PubMed:32152734, PubMed:36482135). Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127 (PubMed:36482135). Involved in the specific removal of group I introns in mitochondrial encoded transcripts (PubMed:19562342, PubMed:19751518, PubMed:20124025, PubMed:22861139)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUT1", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0019843 rRNA binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:2000234 positive regulation of rRNA processing;GO:0000963 mitochondrial RNA processing;GO:0006396 RNA processing;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P48237-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48240-1", "uniprot_id": [ { "id": "MTR3_YEAST", "url": "https://www.uniprot.org/uniprot/P48240", "type": "external" } ], "mass": 27577.0, "length": 250, "protein_name": "Exosome complex component MTR3", "gene_name": "MTR3", "organism": "Yeast", "refseq_name": "exosome non-catalytic core subunit MTR3", "refseq_ac": [ { "id": "NP_011674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011674", "type": "external" } ], "gene_names_uniprotkb": "MTR3; G6676", "gene_names_refseq": "MTR3", "protein_names_uniprotkb": "Exosome complex component MTR3; mRNA transport regulator 3", "protein_names_refseq": "exosome non-catalytic core subunit MTR3", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR158C); (R-SCE-429958); (R-SCE-450385); (R-SCE-450513); (R-SCE-6791226)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10465791;14562095;14562106;16829593;17173052;17174896;21126336;24374639;30181345;33491328;8534909;8585325;9169869", "class_list": "", "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. MTR3 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUT8", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000176 nuclear exosome (RNase complex);GO:0000177 cytoplasmic exosome (RNase complex)", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0006396 RNA processing;GO:0016075 rRNA catabolic process;GO:0006401 RNA catabolic process;GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P48240-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48360-1", "uniprot_id": [ { "id": "ADRO_YEAST", "url": "https://www.uniprot.org/uniprot/P48360", "type": "external" } ], "mass": 56237.0, "length": 493, "protein_name": "Probable NADPH:adrenodoxin oxidoreductase, mitochondrial", "gene_name": "ARH1", "organism": "Yeast", "refseq_name": "NADPH-adrenodoxin reductase", "refseq_ac": [ { "id": "NP_010664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010664", "type": "external" } ], "gene_names_uniprotkb": "ARH1; D9481.5", "gene_names_refseq": "ARH1", "protein_names_uniprotkb": "Probable NADPH:adrenodoxin oxidoreductase, mitochondrial; 1.18.1.6; AR; Adrenodoxin reductase; FDXR; Ferredoxin reductase; Ferredoxin--NADP(+) reductase", "protein_names_refseq": "NADPH-adrenodoxin reductase", "tax_id": 559292, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584); Parkinson's disease (Disease Ontology:DOID:14330); auditory system disease (Disease Ontology:DOID:2742); optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (sce:YDR376W); (R-SCE-2395516)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11035018;11248251;1327750;14562106;15211518;16823961;20534343;21944752;24374639;8890749;9169867;9727014;9818721", "class_list": "", "function": "Adrenodoxin reductase transfers electrons from NADPH to adrenodoxin, which is involved in heme A biosynthesis and in iron-sulfur cluster assembly (PubMed:15211518, PubMed:9727014). Involved in the electron transfer to heme A synthase COX15, a heme protein that catalyzes the conversion of heme O to heme A (PubMed:11248251). Required for the de novo synthesis of Fe-S clusters on iron sulfur cluster assembly protein ISU1. Involved in electron delivery for Fe-S cluster synthesis (PubMed:15211518). Essential for coenzyme Q biosynthesis. May be involved in the electron transfer required for the hydroxylation reaction performed by COQ6 (PubMed:20534343, PubMed:21944752). May play a role in cellular and mitochondrial iron homeostasis (PubMed:11035018)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT08;P32840", "ec_number_list": [ { "id": "1.18.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.18.1.6", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0004324 ferredoxin-NADP+ reductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P48360-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48363-1", "uniprot_id": [ { "id": "PFD3_YEAST", "url": "https://www.uniprot.org/uniprot/P48363", "type": "external" } ], "mass": 23115.0, "length": 199, "protein_name": "Prefoldin subunit 3", "gene_name": "PAC10", "organism": "Yeast", "refseq_name": "tubulin-binding prefolding complex subunit PAC10", "refseq_ac": [ { "id": "NP_011592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011592", "type": "external" } ], "gene_names_uniprotkb": "PAC10; GIM2; PFD3", "gene_names_refseq": "GIM2; PAC10; PFD3; RKS2", "protein_names_uniprotkb": "Prefoldin subunit 3; Genes involved in microtubule biogenesis protein 2; Gim complex subunit 2; GimC subunit 2", "protein_names_refseq": "tubulin-binding prefolding complex subunit PAC10", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YGR078C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;17322287;22814378;24374639;33491328;9169869;9463374;9878052", "class_list": "", "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUL0", "ec_number_list": [], "go_molecular_function": "GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016272 prefoldin complex", "go_biological_process": "GO:0006457 protein folding;GO:0007021 tubulin complex assembly;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P48363-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48412-1", "uniprot_id": [ { "id": "UPF3_YEAST", "url": "https://www.uniprot.org/uniprot/P48412", "type": "external" } ], "mass": 44924.0, "length": 387, "protein_name": "Nonsense-mediated mRNA decay protein 3", "gene_name": "UPF3", "organism": "Yeast", "refseq_name": "Upf3p", "refseq_ac": [ { "id": "NP_011586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011586", "type": "external" } ], "gene_names_uniprotkb": "UPF3; SUA6", "gene_names_refseq": "SUA6; SUP112; UPF3", "protein_names_uniprotkb": "Nonsense-mediated mRNA decay protein 3; Up-frameshift suppressor 3", "protein_names_refseq": "Upf3p", "tax_id": 559292, "disease": "syndromic X-linked intellectual disability 14 (Disease Ontology:DOID:0060821)", "pathway": " (sce:YGR072W); (R-SCE-975957)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11502169;14562106;17322287;24374639;33491328;7479783;9169869", "class_list": "", "function": "Involved in nonsense-mediated decay of mRNAs containing premature stop codons., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUK5;E9P8W8", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay;GO:0006310 DNA recombination;GO:0016567 protein ubiquitination;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P48412-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48439-1", "uniprot_id": [ { "id": "OST3_YEAST", "url": "https://www.uniprot.org/uniprot/P48439", "type": "external" } ], "mass": 39483.0, "length": 350, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3", "gene_name": "OST3", "organism": "Yeast", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycotransferase OST3", "refseq_ac": [ { "id": "NP_014728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014728", "type": "external" } ], "gene_names_uniprotkb": "OST3; YOR3124W", "gene_names_refseq": "OST3", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3; Oligosaccharyl transferase 34 kDa subunit; Oligosaccharyl transferase subunit OST3; Oligosaccharyl transferase subunit gamma", "protein_names_refseq": "dolichyl-diphosphooligosaccharide--protein glycotransferase OST3", "tax_id": 559292, "disease": "X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia (Disease Ontology:DOID:0080319); autosomal recessive intellectual developmental disorder 7 (Disease Ontology:DOID:0081183); congenital disorder of glycosylation Icc (Disease Ontology:DOID:0111839); prostate cancer (Disease Ontology:DOID:10283); bacterial infectious disease (Disease Ontology:DOID:104); primary immunodeficiency disease (Disease Ontology:DOID:612)", "pathway": " (sce:YOR085W); (R-SCE-5223345); (R-SCE-6798695)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10358084;10677492;11580295;14562106;15886282;16096345;16096346;16297388;17322287;24374639;29301962;29466327;7622558;8175708;9169874;9200815;9405463;9878773", "class_list": "", "function": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2E7", "ec_number_list": [], "go_molecular_function": "GO:0015035 protein-disulfide reductase activity;GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006487 protein N-linked glycosylation;GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P48439-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48445-1", "uniprot_id": [ { "id": "BPL1_YEAST", "url": "https://www.uniprot.org/uniprot/P48445", "type": "external" } ], "mass": 76363.0, "length": 690, "protein_name": "Biotin--protein ligase", "gene_name": "BPL1", "organism": "Yeast", "refseq_name": "biotin--[acetyl-CoA-carboxylase] ligase BPL1", "refseq_ac": [ { "id": "NP_010140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010140", "type": "external" } ], "gene_names_uniprotkb": "BPL1; ACC2; D2140", "gene_names_refseq": "ACC2; BPL1", "protein_names_uniprotkb": "Biotin--protein ligase; 6.3.4.-; Biotin apo-protein ligase; HCS; Holocarboxylase synthetase", "protein_names_refseq": "biotin--[acetyl-CoA-carboxylase] ligase BPL1", "tax_id": 559292, "disease": "holocarboxylase synthetase deficiency (Disease Ontology:DOID:859)", "pathway": " (sce:YDL141W); (R-SCE-196780)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14562095;14562106;19779198;24374639;7649444;8972577;9169867", "class_list": "", "function": "Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VRK7", "ec_number_list": [ { "id": "6.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.1", "type": "external" }, { "id": "6.3.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.-", "type": "external" }, { "id": "6.3.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.10", "type": "external" }, { "id": "6.3.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.11", "type": "external" }, { "id": "6.3.4.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.15", "type": "external" }, { "id": "6.3.4.9", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.9", "type": "external" }, { "id": "6.3.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.14", "type": "external" }, { "id": "6.4.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004077 biotin--[biotin carboxyl-carrier protein] ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P48445-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48558-1", "uniprot_id": [ { "id": "BXI1_YEAST", "url": "https://www.uniprot.org/uniprot/P48558", "type": "external" } ], "mass": 33645.0, "length": 297, "protein_name": "Bax inhibitor 1", "gene_name": "BXI1", "organism": "Yeast", "refseq_name": "Bxi1p", "refseq_ac": [ { "id": "NP_014094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014094", "type": "external" } ], "gene_names_uniprotkb": "BXI1; N0405; YBH3", "gene_names_refseq": "BXI1; YBH3", "protein_names_uniprotkb": "Bax inhibitor 1; BH3 domain-containing protein BXI1", "protein_names_refseq": "Bxi1p", "tax_id": 559292, "disease": "chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (sce:YNL305C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562095;16847258;17322287;21673659;21673967;21926971;24374639;33491328;8553702;9169873", "class_list": "", "function": "Links the unfolded protein response and programmed cell death and mediates mitochondrial-dependent apoptosis (PubMed:21673659, PubMed:21673967). Induces cell death and disruption of the mitochondrial transmembrane potential via the mitochondrial phosphate carrier MIR1 (PubMed:21673659). Dispensible for starvation-induced autophagy (PubMed:21926971)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0P0;Q6B2Q1", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0006915 apoptotic process;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P48558-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48559-1", "uniprot_id": [ { "id": "YPT11_YEAST", "url": "https://www.uniprot.org/uniprot/P48559", "type": "external" } ], "mass": 47116.0, "length": 417, "protein_name": "GTP-binding protein YPT11", "gene_name": "YPT11", "organism": "Yeast", "refseq_name": "Rab family GTPase YPT11", "refseq_ac": [ { "id": "NP_014095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014095", "type": "external" } ], "gene_names_uniprotkb": "YPT11; N0410", "gene_names_refseq": "YPT11", "protein_names_uniprotkb": "GTP-binding protein YPT11; Rab GTPase YPT11", "protein_names_refseq": "Rab family GTPase YPT11", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL304W); (R-SCE-6798695); (R-SCE-8873719)", "pathway_count": 3, "publication_count": 24, "publication_id_list": "11785952;11943201;12391144;12748633;12775844;14562106;15201867;15215313;16980630;18245340;18407956;19779198;19795423;19823750;20702584;23427260;23749301;24374639;32597660;33229814;33481703;33491328;8553702;9169873", "class_list": "", "function": "Involved in the positive control of both endoplasmic reticulum (ER) and mitochondrion inheritance during cell divison. Required for the MYO2-dependent retention of newly inherited mitochondria at the bud tip in developing daughter cells., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6W0P1", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0031489 myosin V binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0034389 lipid droplet organization;GO:0051646 mitochondrion localization;GO:0048312 intracellular distribution of mitochondria;GO:0048313 Golgi inheritance", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P48559-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48561-1", "uniprot_id": [ { "id": "TRF5_YEAST", "url": "https://www.uniprot.org/uniprot/P48561", "type": "external" } ], "mass": 74179.0, "length": 642, "protein_name": "Poly(A) RNA polymerase protein 1", "gene_name": "TRF5", "organism": "Yeast", "refseq_name": "non-canonical poly(A) polymerase TRF5", "refseq_ac": [ { "id": "NP_014100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014100", "type": "external" } ], "gene_names_uniprotkb": "TRF5; N0440", "gene_names_refseq": "TRF5", "protein_names_uniprotkb": "Poly(A) RNA polymerase protein 1; 2.7.7.19; Topoisomerase 1-related protein TRF5", "protein_names_refseq": "non-canonical poly(A) polymerase TRF5", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL299W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10926539;11579108;12665575;12748633;14562095;14562106;16260630;16373491;16374505;16431988;17179095;19779198;23749301;24374639;32597660;33481703;33491328;8553702;8710513;9169873", "class_list": "", "function": "Catalytic subunit of the TRAMP5 complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Polyadenylates RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome. TRF5 is also required for proper nuclear division in mitosis and sister chromatid cohesion. Involved in the regulation of histone mRNA levels. May mediate mitotic chromosome condensation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0P5", "ec_number_list": [ { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0031499 TRAMP complex", "go_biological_process": "GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process;GO:0051301 cell division;GO:0071044 histone mRNA catabolic process;GO:0031123 RNA 3'-end processing;GO:0034475 U4 snRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P48561-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48563-1", "uniprot_id": [ { "id": "MON2_YEAST", "url": "https://www.uniprot.org/uniprot/P48563", "type": "external" } ], "mass": 186836.0, "length": 1636, "protein_name": "Protein MON2", "gene_name": "MON2", "organism": "Yeast", "refseq_name": "Mon2p", "refseq_ac": [ { "id": "NP_014102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014102", "type": "external" } ], "gene_names_uniprotkb": "MON2; N0453; YSL2", "gene_names_refseq": "MON2; YSL2", "protein_names_uniprotkb": "Protein MON2", "protein_names_refseq": "Mon2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL297C)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "11875433;12052896;12134085;14562106;15314152;15665377;16219684;16301316;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;22814378;23749301;24374639;28404745;32597660;33481703;33491328;8553702;9169873", "class_list": "", "function": "Required for traffic between late Golgi and early endosomes (PubMed:16219684, PubMed:16301316). Required for endocytosis and maintenance of vacuolar structure (PubMed:12052896, PubMed:12134085, PubMed:16219684)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0P7", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0031901 early endosome membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0042147 retrograde transport, endosome to Golgi;GO:0006895 Golgi to endosome transport;GO:0098629 trans-Golgi network membrane organization;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P48563-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48566-1", "uniprot_id": [ { "id": "GYP3_YEAST", "url": "https://www.uniprot.org/uniprot/P48566", "type": "external" } ], "mass": 72999.0, "length": 633, "protein_name": "GTPase-activating protein GYP3", "gene_name": "MSB3", "organism": "Yeast", "refseq_name": "Rab GTPase-activating protein MSB3", "refseq_ac": [ { "id": "NP_014106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014106", "type": "external" } ], "gene_names_uniprotkb": "MSB3; GYP3; N0470", "gene_names_refseq": "GYP3; MSB3", "protein_names_uniprotkb": "GTPase-activating protein GYP3; Multicopy suppressor of bud emergence 3; Protein MSB3", "protein_names_refseq": "Rab GTPase-activating protein MSB3", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162); Ewing sarcoma (Disease Ontology:DOID:3369)", "pathway": " (sce:YNL293W); (R-SCE-8854214)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10679030;12913108;14562106;18407956;19779198;19795423;19823750;21126336;21177495;23749301;24374639;32597660;33481703;33491328;8553702;9169873", "class_list": "", "function": "Regulates exocytosis by functioning as a GAP for SEC4. Stimulates specifically the GTPase activity of YPT6. Also required for efficient polarization of the actin patches., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0Q0", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005770 late endosome;GO:0071944 cell periphery", "go_biological_process": "GO:0006897 endocytosis;GO:0032880 regulation of protein localization;GO:0006887 exocytosis;GO:0006903 vesicle targeting;GO:0030010 establishment of cell polarity", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P48566-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48581-1", "uniprot_id": [ { "id": "RAD17_YEAST", "url": "https://www.uniprot.org/uniprot/P48581", "type": "external" } ], "mass": 45580.0, "length": 401, "protein_name": "DNA damage checkpoint control protein RAD17", "gene_name": "RAD17", "organism": "Yeast", "refseq_name": "Rad17p", "refseq_ac": [ { "id": "NP_015013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015013", "type": "external" } ], "gene_names_uniprotkb": "RAD17", "gene_names_refseq": "RAD17", "protein_names_uniprotkb": "DNA damage checkpoint control protein RAD17; DNA repair exonuclease RAD17", "protein_names_refseq": "Rad17p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR368W); (R-SCE-176187)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "12271137;12604797;12672803;14562106;15014082;16137930;16169844;16202664;17287358;17563356;18407956;19795423;19823750;21126336;24374639;32597660;33491328;7491494;8649984;9169874;9891048", "class_list": "", "function": "Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. Associates with sites of DNA damage and modulates the MEC1 signaling pathway and the activation of RAD53 in response to DNA damage at phase G1. The complex also physically regulates DNA polymerase zeta-dependent mutagenesis by controlling the access of polymerase zeta to damaged DNA. Contrary to its human counterpart, the 9-1-1 complex, the checkpoint clamp complex shows no detectable exonuclease activity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W361", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003684 damaged DNA binding;GO:0003690 double-stranded DNA binding;GO:0004518 nuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0030896 checkpoint clamp complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006302 double-strand break repair;GO:0000077 DNA damage checkpoint signaling;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P48581-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49017-1", "uniprot_id": [ { "id": "COQ5_YEAST", "url": "https://www.uniprot.org/uniprot/P49017", "type": "external" } ], "mass": 34685.0, "length": 307, "protein_name": "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial", "gene_name": "COQ5", "organism": "Yeast", "refseq_name": "2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase", "refseq_ac": [ { "id": "NP_013597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013597", "type": "external" } ], "gene_names_uniprotkb": "COQ5; DBI56; YM8339.09C", "gene_names_refseq": "COQ5; DBI56", "protein_names_uniprotkb": "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; 2-hexaprenyl-6-methoxy-1,4-benzoquinol methyltransferase; 2.1.1.201; Ubiquinone biosynthesis methyltransferase COQ5", "protein_names_refseq": "2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase", "tax_id": 559292, "disease": "coenzyme Q10 deficiency disease (Disease Ontology:DOID:0050730); primary coenzyme Q10 deficiency 9 (Disease Ontology:DOID:0112138)", "pathway": " (sce:YML110C); (R-SCE-2142789)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "14562095;14562106;14701817;17322287;24374639;24406904;25084328;33491328;33502312;9083048;9083049;9169872", "class_list": "", "function": "Methyltransferase required for the conversion of 2-hexaprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0H4", "ec_number_list": [ { "id": "4.1.1.130", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.130", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.114", "type": "external" }, { "id": "2.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.64", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "1.14.99.60", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.60", "type": "external" }, { "id": "1.14.13.253", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.253", "type": "external" }, { "id": "2.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.201", "type": "external" }, { "id": "3.5.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.-.-", "type": "external" }, { "id": "1.14.15.45", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.45", "type": "external" }, { "id": "1.14.15.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.46", "type": "external" } ], "go_molecular_function": "GO:0008425 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process;GO:0032259 methylation;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P49017-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49018-1", "uniprot_id": [ { "id": "GPI8_YEAST", "url": "https://www.uniprot.org/uniprot/P49018", "type": "external" } ], "mass": 47402.0, "length": 411, "protein_name": "GPI-anchor transamidase", "gene_name": "GPI8", "organism": "Yeast", "refseq_name": "GPI-anchor transamidase", "refseq_ac": [ { "id": "NP_010618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010618", "type": "external" } ], "gene_names_uniprotkb": "GPI8; D9798.2", "gene_names_refseq": "GPI8", "protein_names_uniprotkb": "GPI-anchor transamidase; 3.-.-.-; GPI transamidase", "protein_names_refseq": "GPI-anchor transamidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR331W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10727241;10793132;11598210;14562106;17322287;24374639;8978684;9169867", "class_list": "", "function": "Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VSW3", "ec_number_list": [], "go_molecular_function": "GO:0003923 GPI-anchor transamidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0042765 GPI-anchor transamidase complex", "go_biological_process": "GO:0006508 proteolysis;GO:0006506 GPI anchor biosynthetic process;GO:0016255 attachment of GPI anchor to protein;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P49018-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49095-1", "uniprot_id": [ { "id": "GCSP_YEAST", "url": "https://www.uniprot.org/uniprot/P49095", "type": "external" } ], "mass": 114451.0, "length": 1034, "protein_name": "Glycine dehydrogenase (decarboxylating), mitochondrial", "gene_name": "GCV2", "organism": "Yeast", "refseq_name": "glycine decarboxylase subunit P", "refseq_ac": [ { "id": "NP_013914", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013914", "type": "external" } ], "gene_names_uniprotkb": "GCV2; GSD2; YM9646.01", "gene_names_refseq": "GCV2; GSD2", "protein_names_uniprotkb": "Glycine dehydrogenase (decarboxylating), mitochondrial; 1.4.4.2; Glycine cleavage system P protein; Glycine decarboxylase complex subunit P; Glycine decarboxylase; Glycine dehydrogenase (aminomethyl-transferring)", "protein_names_refseq": "glycine decarboxylase subunit P", "tax_id": 559292, "disease": "glycine encephalopathy 1 (Disease Ontology:DOID:0070616); stomach cancer (Disease Ontology:DOID:10534); glycine encephalopathy (Disease Ontology:DOID:9268)", "pathway": " (sce:YMR189W); (R-SCE-6783984)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14562106;21126336;23749301;24374639;32597660;33491328;8830251;9169872", "class_list": "", "function": "The glycine cleavage system (glycine decarboxylase complex) catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W013", "ec_number_list": [ { "id": "1.4.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.4.2", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004375 glycine dehydrogenase (decarboxylating) activity;GO:0016594 glycine binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005960 glycine cleavage complex", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0019464 glycine decarboxylation via glycine cleavage system;GO:0006546 glycine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P49095-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49367-1", "uniprot_id": [ { "id": "LYS4_YEAST", "url": "https://www.uniprot.org/uniprot/P49367", "type": "external" } ], "mass": 75151.0, "length": 693, "protein_name": "Homoaconitase, mitochondrial", "gene_name": "LYS4", "organism": "Yeast", "refseq_name": "homoaconitate hydratase LYS4", "refseq_ac": [ { "id": "NP_010520", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010520", "type": "external" } ], "gene_names_uniprotkb": "LYS4; LYS3; YD8419.01; YD9934.18", "gene_names_refseq": "LYS3; LYS4", "protein_names_uniprotkb": "Homoaconitase, mitochondrial; 4.2.1.36; Homoaconitate hydratase", "protein_names_refseq": "homoaconitate hydratase LYS4", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR234W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10714900;14562095;14562106;17322287;23106124;24374639;2507177;33491328;5908136;6051343;9169867;9541534", "class_list": "", "function": "Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSL5;Q66RF2;Q7LH77", "ec_number_list": [ { "id": "4.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.36", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0004409 homoaconitate hydratase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0019878 lysine biosynthetic process via aminoadipic acid", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P49367-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49435-1", "uniprot_id": [ { "id": "APT1_YEAST", "url": "https://www.uniprot.org/uniprot/P49435", "type": "external" } ], "mass": 20587.0, "length": 187, "protein_name": "Adenine phosphoribosyltransferase 1", "gene_name": "APT1", "organism": "Yeast", "refseq_name": "adenine phosphoribosyltransferase APT1", "refseq_ac": [ { "id": "NP_013690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013690", "type": "external" } ], "gene_names_uniprotkb": "APT1", "gene_names_refseq": "APT1", "protein_names_uniprotkb": "Adenine phosphoribosyltransferase 1; 2.4.2.7; APRT 1", "protein_names_refseq": "adenine phosphoribosyltransferase APT1", "tax_id": 559292, "disease": "adenine phosphoribosyltransferase deficiency (Disease Ontology:DOID:0060350); Lesch-Nyhan syndrome (Disease Ontology:DOID:1919); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YML022W); (R-SCE-6798695); (R-SCE-74217)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "11535055;14562095;14562106;17322287;18407956;24374639;29178779;32597660;33481703;33491328;7642142;9169872;9357956;9864350", "class_list": "", "function": "Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZF2;Q6Q5A3", "ec_number_list": [ { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.7.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.59", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016208 AMP binding;GO:0002055 adenine binding;GO:0003999 adenine phosphoribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0044209 AMP salvage;GO:0006166 purine ribonucleoside salvage;GO:0006168 adenine salvage", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P49435-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49573-1", "uniprot_id": [ { "id": "CTR1_YEAST", "url": "https://www.uniprot.org/uniprot/P49573", "type": "external" } ], "mass": 44442.0, "length": 406, "protein_name": "Copper transport protein CTR1", "gene_name": "CTR1", "organism": "Yeast", "refseq_name": "high-affinity Cu transporter CTR1", "refseq_ac": [ { "id": "NP_015449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015449", "type": "external" } ], "gene_names_uniprotkb": "CTR1; P9642.3", "gene_names_refseq": "CTR1", "protein_names_uniprotkb": "Copper transport protein CTR1; Copper transporter 1", "protein_names_refseq": "high-affinity Cu transporter CTR1", "tax_id": 559292, "disease": "Menkes disease (Disease Ontology:DOID:1838)", "pathway": " (sce:YPR124W)", "pathway_count": 1, "publication_count": 33, "publication_id_list": "10480908;10922376;11557497;12011036;12370430;12391279;14511662;14562106;15012137;17322287;17330950;17563356;18407956;19779198;21126336;21177495;22106047;23749301;24374639;30516470;32597660;33481703;33491328;7929270;8293472;8670854;8756349;9169875;9188496;9211922;9599102;9726991;9867833", "class_list": "", "function": "High-affinity copper transporter of plasma membrane that mediates copper uptake under low copper conditions (PubMed:12391279, PubMed:7929270, PubMed:8293472, PubMed:8756349). Copper transport through the high affinity system requiring CTRl supplies the iron transport multicopper ferroxidase FET3 with copper, which in turn is required for ferrous iron uptake (PubMed:8293472). The energy for translocation is unlikely to be directly derived from ATP hydrolysis and the exact mechanism driving the transmembrane transport of copper has still to be determined (PubMed:7929270). Binds 4 copper ions via its C-terminal cystein-rich domain and is able to deliver Cu(I) directly to both the chaperone ATX1 and to an N-terminal domain of the CCC2 protein (PubMed:15012137). Also able to mediate the uptake of the anticancer drug cisplatin (PubMed:12370430, PubMed:12391279, PubMed:14511662)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4C2", "ec_number_list": [], "go_molecular_function": "GO:0005375 copper ion transmembrane transporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0035434 copper ion transmembrane transport;GO:0015677 copper ion import", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P49573-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49626-1", "uniprot_id": [ { "id": "RL4B_YEAST", "url": "https://www.uniprot.org/uniprot/P49626", "type": "external" } ], "mass": 39062.0, "length": 362, "protein_name": "Large ribosomal subunit protein uL4B", "gene_name": "RPL4B", "organism": "Yeast", "refseq_name": "60S ribosomal protein uL4 RPL4B", "refseq_ac": [ { "id": "NP_010295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010295", "type": "external" } ], "gene_names_uniprotkb": "RPL4B; RPL2B; YD8119.17", "gene_names_refseq": "RPL4B", "protein_names_uniprotkb": "Large ribosomal subunit protein uL4B; 60S ribosomal protein L4-B; L2; RP2; YL2", "protein_names_refseq": "60S ribosomal protein uL4 RPL4B", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR012W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 18, "publication_id_list": "14562095;14562106;14976550;1544921;17287358;17322287;20702584;22096102;24374639;24524803;25936803;26046779;30516470;3062369;32597660;8896275;9169867;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRZ8", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P49626-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49686-1", "uniprot_id": [ { "id": "NUP42_YEAST", "url": "https://www.uniprot.org/uniprot/P49686", "type": "external" } ], "mass": 42778.0, "length": 430, "protein_name": "Nucleoporin NUP42", "gene_name": "NUP42", "organism": "Yeast", "refseq_name": "FG-nucleoporin NUP42", "refseq_ac": [ { "id": "NP_010478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010478", "type": "external" } ], "gene_names_uniprotkb": "NUP42; RIP1; UIP1; YD9346.04C", "gene_names_refseq": "NUP42; RIP1; UIP1", "protein_names_uniprotkb": "Nucleoporin NUP42; Nuclear pore protein NUP42", "protein_names_refseq": "FG-nucleoporin NUP42", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR192C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10523319;10610322;10684247;10805742;10952996;11387327;12604785;12791264;12917401;15039779;17322287;18407956;19779198;19795423;19823750;22218487;23749301;24374639;30516470;33229814;33481703;33491328;7634338;9169867", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP42 is specifically important for nuclear protein and mRNA export., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6VSH5", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0044614 nuclear pore cytoplasmic filaments;GO:0044613 nuclear pore central transport channel", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0031990 mRNA export from nucleus in response to heat stress;GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery;GO:0006607 NLS-bearing protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P49686-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49704-1", "uniprot_id": [ { "id": "PRP31_YEAST", "url": "https://www.uniprot.org/uniprot/P49704", "type": "external" } ], "mass": 56303.0, "length": 494, "protein_name": "Pre-mRNA-processing factor 31", "gene_name": "PRP31", "organism": "Yeast", "refseq_name": "U4/U6-U5 snRNP complex subunit PRP31", "refseq_ac": [ { "id": "NP_011605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011605", "type": "external" } ], "gene_names_uniprotkb": "PRP31", "gene_names_refseq": "PRP31", "protein_names_uniprotkb": "Pre-mRNA-processing factor 31", "protein_names_refseq": "U4/U6-U5 snRNP complex subunit PRP31", "tax_id": 559292, "disease": "retinitis pigmentosa 11 (Disease Ontology:DOID:0110408); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (sce:YGR091W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10377396;10449419;11804584;14562106;17322287;18953335;24374639;33491328;8604353;9169869;9199293", "class_list": "", "function": "Promotes the association of the U4/U6.U5 tri-snRNP particle with pre-spliceosomes to form the mature spliceosomal complex., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUM3;Q66R99", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0071011 precatalytic spliceosome;GO:0005687 U4 snRNP;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P49704-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49775-1", "uniprot_id": [ { "id": "HNT2_YEAST", "url": "https://www.uniprot.org/uniprot/P49775", "type": "external" } ], "mass": 23542.0, "length": 206, "protein_name": "Bis(5'-adenosyl)-triphosphatase", "gene_name": "HNT2", "organism": "Yeast", "refseq_name": "bis(5'-adenosyl)-triphosphatase", "refseq_ac": [ { "id": "NP_010591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010591", "type": "external" } ], "gene_names_uniprotkb": "HNT2; APH1; D9740.15", "gene_names_refseq": "APH1; HNT2", "protein_names_uniprotkb": "Bis(5'-adenosyl)-triphosphatase; 3.6.1.29; AP3A hydrolase; AP3Aase; Diadenosine 5',5'''-P1,P3-triphosphate hydrolase; Dinucleosidetriphosphatase; Hit family protein 2", "protein_names_refseq": "bis(5'-adenosyl)-triphosphatase", "tax_id": 559292, "disease": "Muir-Torre syndrome (Disease Ontology:DOID:0050465); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); squamous cell carcinoma (Disease Ontology:DOID:1749); granulosa cell tumor (Disease Ontology:DOID:2999); invasive ductal carcinoma (Disease Ontology:DOID:3008); lung non-small cell carcinoma (Disease Ontology:DOID:3908); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YDR305C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12028594;14562095;14562106;1653209;16823961;24374639;33491328;9169867;9573184", "class_list": "", "function": "Cleaves A-5'-PPP-5'A to yield AMP and ADP. Can cleave all dinucleoside polyphosphates, provided the phosphate chain contains at least 3 phosphates and that 1 of the 2 bases composing the nucleotide is a purine. Is most effective on dinucleoside triphosphates. Negatively regulates intracellular dinucleoside polyphosphate levels, which elevate following heat shock., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VST4;Q6TQU2;Q6TQU3", "ec_number_list": [ { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0000166 nucleotide binding;GO:0004081 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity;GO:0017111 ribonucleoside triphosphate phosphatase activity;GO:0047710 bis(5'-adenosyl)-triphosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0009164 nucleoside catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P49775-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49955-1", "uniprot_id": [ { "id": "SF3B1_YEAST", "url": "https://www.uniprot.org/uniprot/P49955", "type": "external" } ], "mass": 110028.0, "length": 971, "protein_name": "U2 snRNP component HSH155", "gene_name": "HSH155", "organism": "Yeast", "refseq_name": "U2 snRNP complex subunit HSH155", "refseq_ac": [ { "id": "NP_014015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014015", "type": "external" } ], "gene_names_uniprotkb": "HSH155; YM8021.14", "gene_names_refseq": "HSH155", "protein_names_uniprotkb": "U2 snRNP component HSH155", "protein_names_refseq": "U2 snRNP complex subunit HSH155", "tax_id": 559292, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); uterine corpus endometrial carcinoma (Disease Ontology:DOID:0050939); bladder urothelial carcinoma (Disease Ontology:DOID:4006); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (sce:YMR288W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11884590;14517302;14562106;18407956;21177495;23749301;24374639;33491328;9169872", "class_list": "", "function": "Contacts pre-mRNA on both sides of the branch site early in spliceosome assembly., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0B5", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:1903241 U2-type prespliceosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P49955-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49956-1", "uniprot_id": [ { "id": "CTF18_YEAST", "url": "https://www.uniprot.org/uniprot/P49956", "type": "external" } ], "mass": 84373.0, "length": 741, "protein_name": "Chromosome transmission fidelity protein 18", "gene_name": "CTF18", "organism": "Yeast", "refseq_name": "Ctf18p", "refseq_ac": [ { "id": "NP_013795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013795", "type": "external" } ], "gene_names_uniprotkb": "CTF18; CHL12; YM9582.03C", "gene_names_refseq": "CHL12; CTF18", "protein_names_uniprotkb": "Chromosome transmission fidelity protein 18", "protein_names_refseq": "Ctf18p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR078C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11287619;11389843;11486023;12665596;15964801;18407956;19779198;20702584;21126336;23749301;24374639;30516470;32597660;33481703;33491328;7896091;9169872", "class_list": "", "function": "Essential for the fidelity of chromosome transmission. Required for the DNA replication block checkpoint. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZQ2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0031390 Ctf18 RFC-like complex", "go_biological_process": "GO:0000724 double-strand break repair via homologous recombination;GO:0006270 DNA replication initiation;GO:0007064 mitotic sister chromatid cohesion;GO:0034398 telomere tethering at nuclear periphery;GO:0035753 maintenance of DNA trinucleotide repeats", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P49956-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49957-1", "uniprot_id": [ { "id": "TRM9_YEAST", "url": "https://www.uniprot.org/uniprot/P49957", "type": "external" } ], "mass": 32439.0, "length": 279, "protein_name": "tRNA (carboxymethyluridine(34)-5-O)-methyltransferase", "gene_name": "TRM9", "organism": "Yeast", "refseq_name": "tRNA (carboxymethyluridine(34)-5-O)-methyltransferase", "refseq_ac": [ { "id": "NP_013698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013698", "type": "external" } ], "gene_names_uniprotkb": "TRM9; YM9571.04", "gene_names_refseq": "KTI1; TRM9", "protein_names_uniprotkb": "tRNA (carboxymethyluridine(34)-5-O)-methyltransferase; 2.1.1.229; tRNA (uracil-5-)-methyltransferase TRM9; tRNA [Um34] methyltransferase; tRNA methylase 9", "protein_names_refseq": "tRNA (carboxymethyluridine(34)-5-O)-methyltransferase", "tax_id": 559292, "disease": "autosomal recessive intellectual developmental disorder 71 (Disease Ontology:DOID:0081232)", "pathway": " (sce:YML014W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;14562106;14645538;15899842;19795423;19823750;21177495;24374639;32597660;33491328;9169872", "class_list": "", "function": "Required for the methylation of the wobble bases at position 34 in tRNA. Appears to have a role in stress-response., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZG0", "ec_number_list": [ { "id": "2.1.1.229", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.229", "type": "external" } ], "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:0000049 tRNA binding;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0016300 tRNA (uridine) methyltransferase activity;GO:0106335 tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006400 tRNA modification;GO:0006448 regulation of translational elongation;GO:0002098 tRNA wobble uridine modification;GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P49957-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49960-1", "uniprot_id": [ { "id": "SART3_YEAST", "url": "https://www.uniprot.org/uniprot/P49960", "type": "external" } ], "mass": 50849.0, "length": 444, "protein_name": "U4/U6 snRNA-associated-splicing factor PRP24", "gene_name": "PRP24", "organism": "Yeast", "refseq_name": "U6 snRNP complex subunit PRP24", "refseq_ac": [ { "id": "NP_013995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013995", "type": "external" } ], "gene_names_uniprotkb": "PRP24; YM8156.10C", "gene_names_refseq": "PRP24", "protein_names_uniprotkb": "U4/U6 snRNA-associated-splicing factor PRP24; U4/U6 snRNP protein", "protein_names_refseq": "U6 snRNP complex subunit PRP24", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR268C)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "14562106;17320109;17322287;17563356;1827420;18407956;19779198;19795423;19823750;20181740;21653550;23749301;24374639;24837192;28045380;29717126;32597660;33481703;33491328;7585243;7882985;9169872;9452384", "class_list": "", "function": "Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns (PubMed:1827420, PubMed:21653550, PubMed:24837192, PubMed:7585243, PubMed:7882985, PubMed:9452384). Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4 (PubMed:1827420, PubMed:21653550, PubMed:24837192, PubMed:29717126, PubMed:7585243, PubMed:7882985, PubMed:9452384)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W094;E9P966", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0017069 snRNA binding;GO:0017070 U6 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:1990904 ribonucleoprotein complex;GO:0005688 U6 snRNP", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P49960-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50079-1", "uniprot_id": [ { "id": "HSV2_YEAST", "url": "https://www.uniprot.org/uniprot/P50079", "type": "external" } ], "mass": 51235.0, "length": 448, "protein_name": "SVP1-like protein 2", "gene_name": "HSV2", "organism": "Yeast", "refseq_name": "phosphatidylinositol-3,5-bisphosphate binding protein HSV2", "refseq_ac": [ { "id": "NP_011739", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011739", "type": "external" } ], "gene_names_uniprotkb": "HSV2; G8530", "gene_names_refseq": "HSV2", "protein_names_uniprotkb": "SVP1-like protein 2", "protein_names_refseq": "phosphatidylinositol-3,5-bisphosphate binding protein HSV2", "tax_id": 559292, "disease": "neurodegeneration with brain iron accumulation 5 (Disease Ontology:DOID:0110739)", "pathway": " (sce:YGR223C); (R-SCE-1632852)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11536337;15103325;18769150;19756047;24374639;8701610;9169869", "class_list": "", "function": "Involved in piecemeal microautophagy of the nucleus (micronucleophagy)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6VV05", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0030674 protein-macromolecule adaptor activity;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0010008 endosome membrane;GO:0034045 phagophore assembly site membrane", "go_biological_process": "GO:0034497 protein localization to phagophore assembly site;GO:0000422 autophagy of mitochondrion;GO:0044804 nucleophagy;GO:0034727 piecemeal microautophagy of the nucleus;GO:0061723 glycophagy", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P50079-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50082-1", "uniprot_id": [ { "id": "AMA1_YEAST", "url": "https://www.uniprot.org/uniprot/P50082", "type": "external" } ], "mass": 67027.0, "length": 593, "protein_name": "Meiosis-specific APC/C activator protein AMA1", "gene_name": "AMA1", "organism": "Yeast", "refseq_name": "Ama1p", "refseq_ac": [ { "id": "NP_011741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011741", "type": "external" } ], "gene_names_uniprotkb": "AMA1; G8541; SPO70", "gene_names_refseq": "AMA1; SPO70", "protein_names_uniprotkb": "Meiosis-specific APC/C activator protein AMA1; Activator of meiotic APC/C protein 1; Sporulation-specific protein 70", "protein_names_refseq": "Ama1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR225W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10734188;11114178;24374639;8701610;9169869;9784122", "class_list": "", "function": "Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). Required for the ubiquitination and subsequent degradation of the B-type cyclin CLB1 by the APC/C complex during meiosis. Required for meiosis I, late meiotic gene expression and spore wall assembly., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV07;Q96VQ3", "ec_number_list": [], "go_molecular_function": "GO:0010997 anaphase-promoting complex binding;GO:1990757 ubiquitin ligase activator activity", "go_cellular_component": "GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0016567 protein ubiquitination;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0045732 positive regulation of protein catabolic process;GO:0007130 synaptonemal complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P50082-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50085-1", "uniprot_id": [ { "id": "PHB2_YEAST", "url": "https://www.uniprot.org/uniprot/P50085", "type": "external" } ], "mass": 34407.0, "length": 310, "protein_name": "Prohibitin-2", "gene_name": "PHB2", "organism": "Yeast", "refseq_name": "prohibitin subunit PHB2", "refseq_ac": [ { "id": "NP_011747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011747", "type": "external" } ], "gene_names_uniprotkb": "PHB2; G8561", "gene_names_refseq": "PHB2", "protein_names_uniprotkb": "Prohibitin-2", "protein_names_refseq": "prohibitin subunit PHB2", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR231C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10207067;10835343;12237468;12748633;14562095;14562106;14576278;15525670;24374639;38964378;8701610;9169869", "class_list": "", "function": "Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins (PubMed:10835343). Involved in mitophagy; may act as an adapter for ATG8 that supports mitophagosome assembly (PubMed:38964378). Negatively regulates the proteolytic processing of ATG32 via the i-AAA protease (PubMed:38964378). Acts as a negative regulator of the m-AAA protease (PubMed:10207067)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV11", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0007005 mitochondrion organization;GO:0045861 negative regulation of proteolysis;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P50085-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50087-1", "uniprot_id": [ { "id": "MIC26_YEAST", "url": "https://www.uniprot.org/uniprot/P50087", "type": "external" } ], "mass": 26912.0, "length": 233, "protein_name": "MICOS subunit MIC26", "gene_name": "MIC26", "organism": "Yeast", "refseq_name": "Mic26p", "refseq_ac": [ { "id": "NP_011751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011751", "type": "external" } ], "gene_names_uniprotkb": "MIC26; G8575; MCS29; MIO27; MOS2", "gene_names_refseq": "MCS29; MIC26; MIO27; MOS2", "protein_names_uniprotkb": "MICOS subunit MIC26; MitOS2; Mitochondrial contact site complex 29 kDa subunit; Mitochondrial inner membrane organization component of 27 kDa; Mitochondrial organizing structure protein 2", "protein_names_refseq": "Mic26p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR235C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562106;17322287;21126336;21944719;21987634;22009199;24374639;24687277;8701610;9169869", "class_list": "", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, 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"url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.7.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.59", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.3.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0003938 IMP dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006177 GMP biosynthetic process;GO:0006183 GTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P50095-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50101-1", "uniprot_id": [ { "id": "UBP15_YEAST", "url": "https://www.uniprot.org/uniprot/P50101", "type": "external" } ], "mass": 143564.0, "length": 1230, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 15", "gene_name": "UBP15", "organism": "Yeast", "refseq_name": "ubiquitin-specific protease UBP15", "refseq_ac": [ { "id": "NP_014033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014033", "type": "external" } ], "gene_names_uniprotkb": "UBP15; YM9952.06", "gene_names_refseq": "UBP15", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 15; 3.4.19.12; Deubiquitinating enzyme 15; Ubiquitin thioesterase 15; Ubiquitin-specific-processing protease 15", "protein_names_refseq": "ubiquitin-specific protease UBP15", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR304W); (R-SCE-6782135); (R-SCE-6782210)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "14562106;19779198;21126336;21665945;24374639;33491328;9169872", "class_list": "", "function": "Deubiquitinase involved in peroxisome import by mediating deubiquitination of the peroxisomal import receptor PEX5 (PubMed:21665945). Catalyzes deubiquitination of both monoubiquitiated and polyubiquitinated forms of PEX5 following its retrotranslocation into the cytosol, resetting PEX5 for a subsequent import cycle (PubMed:21665945)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0D1", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" } ], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0010995 free ubiquitin chain depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P50101-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50102-1", "uniprot_id": [ { "id": "UBP8_YEAST", "url": "https://www.uniprot.org/uniprot/P50102", "type": "external" } ], "mass": 53623.0, "length": 471, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 8", "gene_name": "UBP8", "organism": "Yeast", "refseq_name": "ubiquitin-specific protease UBP8", "refseq_ac": [ { "id": "NP_013950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013950", "type": "external" } ], "gene_names_uniprotkb": "UBP8; YM9959.05", "gene_names_refseq": "UBP8", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 8; 3.4.19.12; Deubiquitinating enzyme 8; SAGA complex subunit UBP8; Ubiquitin thioesterase 8; Ubiquitin-specific-processing protease 8", "protein_names_refseq": "ubiquitin-specific protease UBP8", "tax_id": 559292, "disease": "non-syndromic X-linked intellectual disability 105 (Disease Ontology:DOID:0112036); glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (sce:YMR223W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10026213;10864329;12052880;12446794;14562106;14563679;14660634;15647753;15657441;15657442;20395473;20434206;22771212;23209445;24374639;25216679;26912860;28918903;31969703;33864814;9169872", "class_list": "", "function": "Histone deubiquitinating enzyme component of the transcription coactivator SAGA complex (PubMed:14563679, PubMed:14660634, PubMed:25216679, PubMed:28918903). SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription (PubMed:10864329, PubMed:25216679, PubMed:28918903). At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module) (PubMed:31969703). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B (PubMed:10026213, PubMed:14660634, PubMed:15657441). SAGA interacts with DNA via upstream activating sequences (UASs) (PubMed:28918903). Also identified in a modified version of SAGA named SALSA or SLIK (PubMed:12446794, PubMed:14660634, PubMed:15647753). The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities (PubMed:33864814). Within the DUB module, the correctly positioned zinc finger domains of SGF11 and SGF73 are both required to fully activate the ubiquitin hydrolase UBP8 (PubMed:15657442, PubMed:20434206). The DUB module is also linked to the splicing efficiency of many transcripts (PubMed:23209445)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W048", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0071819 DUBm complex;GO:0000124 SAGA complex;GO:0046695 SLIK (SAGA-like) complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P50102-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50106-1", "uniprot_id": [ { "id": "RPA14_YEAST", "url": "https://www.uniprot.org/uniprot/P50106", "type": "external" } ], "mass": 14585.0, "length": 137, "protein_name": "DNA-directed RNA polymerase I subunit RPA14", "gene_name": "RPA14", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase I subunit RPA14", "refseq_ac": [ { "id": "NP_010440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010440", "type": "external" } ], "gene_names_uniprotkb": "RPA14; YD8358.11", "gene_names_refseq": "RPA14", "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit RPA14; A14; DNA-directed RNA polymerase I 14 kDa polypeptide", "protein_names_refseq": "DNA-directed RNA polymerase I subunit RPA14", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR156W)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "11918799;12145213;12407181;12888498;14562095;14562106;17287358;17322287;17563356;18160037;18407956;19779198;19795423;19823750;21177495;22218487;23749301;24153182;24153184;24374639;30516470;32597660;33481703;33491328;7768955;9169867", "class_list": "", "function": "DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. RPA14 seems to play a role in the stability of subunits RPO26 and RPA43. In vitro, the RPA14-RPA43 subcomplex binds single-stranded RNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSD7", "ec_number_list": [], "go_molecular_function": "GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005736 RNA polymerase I complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042254 ribosome biogenesis;GO:0006362 transcription elongation by RNA polymerase I;GO:0006361 transcription initiation at RNA polymerase I promoter;GO:0006363 termination of RNA polymerase I transcription", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P50106-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50107-1", "uniprot_id": [ { "id": "LGUL_YEAST", "url": "https://www.uniprot.org/uniprot/P50107", "type": "external" } ], "mass": 37209.0, "length": 326, "protein_name": "Glyoxalase I", "gene_name": "GLO1", "organism": "Yeast", "refseq_name": "lactoylglutathione lyase GLO1", "refseq_ac": [ { "id": "NP_013710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013710", "type": "external" } ], "gene_names_uniprotkb": "GLO1; YM9571.15C", "gene_names_refseq": "GLO1", "protein_names_uniprotkb": "Glyoxalase I; 4.4.1.5; Aldoketomutase; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; actoylglutathione lyase", "protein_names_refseq": "lactoylglutathione lyase GLO1", "tax_id": 559292, "disease": "autistic disorder (Disease Ontology:DOID:12849); vascular disease (Disease Ontology:DOID:178); end stage renal disease (Disease Ontology:DOID:783); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YML004C); (R-SCE-70268)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11050082;14562106;1777125;19795423;19823750;24374639;32597660;33481703;33491328;8670139;8824231;9169872", "class_list": "", "function": "Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:11050082, PubMed:8824231). Can use gamma-glutamylcysteine as a substrate (PubMed:8824231)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZH1;Q9HFG0;Q9URB5", "ec_number_list": [ { "id": "4.4.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.5", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004462 lactoylglutathione lyase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P50107-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50264-1", "uniprot_id": [ { "id": "FMS1_YEAST", "url": "https://www.uniprot.org/uniprot/P50264", "type": "external" } ], "mass": 57806.0, "length": 508, "protein_name": "Polyamine oxidase FMS1", "gene_name": "FMS1", "organism": "Yeast", "refseq_name": "polyamine oxidase", "refseq_ac": [ { "id": "NP_013733", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013733", "type": "external" } ], "gene_names_uniprotkb": "FMS1; YM9711.09", "gene_names_refseq": "FMS1", "protein_names_uniprotkb": "Polyamine oxidase FMS1; 1.5.3.17; Fenpropimorph resistance multicopy suppressor 1", "protein_names_refseq": "polyamine oxidase", "tax_id": 559292, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Brunner Syndrome (Disease Ontology:DOID:0060693); Alzheimer's disease (Disease Ontology:DOID:10652); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); transient cerebral ischemia (Disease Ontology:DOID:224); lung non-small cell carcinoma (Disease Ontology:DOID:3908); schizophrenia (Disease Ontology:DOID:5419); panic disorder (Disease Ontology:DOID:594); hepatocellular carcinoma (Disease Ontology:DOID:684); retinoblastoma (Disease Ontology:DOID:768); diabetic retinopathy (Disease Ontology:DOID:8947); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (sce:YMR020W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12670477;14562106;14617780;24374639;33491328;8660467;9169872", "class_list": "", "function": "Involved in the production of beta-alanine, a precursor of pantothenic acid. Multicopy suppressor of fenpropimorph resistance., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZJ4", "ec_number_list": [ { "id": "1.5.3.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.17", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0046592 polyamine oxidase activity;GO:0052901 spermine oxidase activity;GO:0052903 N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity;GO:0052897 N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0046208 spermine catabolic process;GO:0015940 pantothenate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P50264-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50275-1", "uniprot_id": [ { "id": "ASE1_YEAST", "url": "https://www.uniprot.org/uniprot/P50275", "type": "external" } ], "mass": 101624.0, "length": 885, "protein_name": "Anaphase spindle elongation protein", "gene_name": "ASE1", "organism": "Yeast", "refseq_name": "Ase1p", "refseq_ac": [ { "id": "NP_116582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116582", "type": "external" } ], "gene_names_uniprotkb": "ASE1; YOR29-09", "gene_names_refseq": "ASE1; YOR29-09", "protein_names_uniprotkb": "Anaphase spindle elongation protein", "protein_names_refseq": "Ase1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR058C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562106;14636562;17562791;17765685;19686685;19779198;23749301;24374639;32597660;33481703;33491328;7559759;9133743;9169874", "class_list": "", "function": "Required for anaphase spindle elongation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 41, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2C1", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005874 microtubule;GO:0072686 mitotic spindle;GO:1990023 mitotic spindle midzone", "go_biological_process": "GO:0000920 septum digestion after cytokinesis;GO:0000226 microtubule cytoskeleton organization;GO:0007052 mitotic spindle organization;GO:0051256 mitotic spindle midzone assembly;GO:0001578 microtubule bundle formation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P50275-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50623-1", "uniprot_id": [ { "id": "UBC9_YEAST", "url": "https://www.uniprot.org/uniprot/P50623", "type": "external" } ], "mass": 17911.0, "length": 157, "protein_name": "SUMO-conjugating enzyme UBC9", "gene_name": "UBC9", "organism": "Yeast", "refseq_name": "E2 SUMO-conjugating protein UBC9", "refseq_ac": [ { "id": "NP_010219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010219", "type": "external" } ], "gene_names_uniprotkb": "UBC9", "gene_names_refseq": "UBC9", "protein_names_uniprotkb": "SUMO-conjugating enzyme UBC9; 2.3.2.-; RING-type E3 SUMO transferase UBC9; Ubiquitin carrier protein 9; Ubiquitin-conjugating enzyme E2-18 kDa; Ubiquitin-protein ligase", "protein_names_refseq": "E2 SUMO-conjugating protein UBC9", "tax_id": 559292, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); cancer (Disease Ontology:DOID:162); ovarian cancer (Disease Ontology:DOID:2394); hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (sce:YDL064W); (R-SCE-3065678); (R-SCE-3108214); (R-SCE-3232118); (R-SCE-3899300); (R-SCE-4085377); (R-SCE-4551638); (R-SCE-4570464); (R-SCE-4615885); (R-SCE-9615933); (R-SCE-9793242); (R-SCE-9856649)", "pathway_count": 12, "publication_count": 10, "publication_id_list": "11572779;11587849;14562095;14562106;22814378;24374639;33491328;7800043;9169867;9341106", "class_list": "", "function": "E2 ubiquitin-like--protein ligase mediating SUMO/Smt3 attachment to septins and PCNA. Seems to be involved in degradation of S- (CLB5) and M-phase cyclins (CLB2)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRT3", "ec_number_list": [ { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "5.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019789 SUMO transferase activity;GO:0061656 SUMO conjugating enzyme activity", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus", "go_biological_process": "GO:0016925 protein sumoylation;GO:0051301 cell division;GO:0000022 mitotic spindle elongation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P50623-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50861-1", "uniprot_id": [ { "id": "RIB4_YEAST", "url": "https://www.uniprot.org/uniprot/P50861", "type": "external" } ], "mass": 18556.0, "length": 169, "protein_name": "6,7-dimethyl-8-ribityllumazine synthase", "gene_name": "RIB4", "organism": "Yeast", "refseq_name": "lumazine synthase RIB4", "refseq_ac": [ { "id": "NP_014498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014498", "type": "external" } ], "gene_names_uniprotkb": "RIB4", "gene_names_refseq": "RIB4", "protein_names_uniprotkb": "6,7-dimethyl-8-ribityllumazine synthase; 2.5.1.78; DMRL synthase; LS; Lumazine synthase", "protein_names_refseq": "lumazine synthase RIB4", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL143C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10860731;14562106;17322287;22814378;22984289;24374639;33491328;7559556;8969176;9169874", "class_list": "", "function": "Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1S6;Q08286", "ec_number_list": [ { "id": "2.5.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.78", "type": "external" } ], "go_molecular_function": "GO:0000906 6,7-dimethyl-8-ribityllumazine synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005758 mitochondrial intermembrane space;GO:0009349 riboflavin synthase complex", "go_biological_process": "GO:0009231 riboflavin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P50861-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50945-1", "uniprot_id": [ { "id": "MIC27_YEAST", "url": "https://www.uniprot.org/uniprot/P50945", "type": "external" } ], "mass": 26960.0, "length": 234, "protein_name": "MICOS complex subunit MIC27", "gene_name": "MIC27", "organism": "Yeast", "refseq_name": "Mic27p", "refseq_ac": [ { "id": "NP_014299", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014299", "type": "external" } ], "gene_names_uniprotkb": "MIC27; AIM37; MCS27; N2190", "gene_names_refseq": "AIM37; MCS27; MIC27", "protein_names_uniprotkb": "MICOS complex subunit MIC27; Altered inheritance of mitochondria protein 37; Mitochondrial contact site complex 27 kDa subunit", "protein_names_refseq": "Mic27p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL100W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562095;14562106;16273108;17005538;17322287;19300474;21944719;21987634;22009199;24374639;24687277;8701612;9169873", "class_list": "", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W179;Q45U03", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0044284 mitochondrial crista junction;GO:0061617 MICOS complex", "go_biological_process": "GO:0032461 positive regulation of protein oligomerization;GO:0042407 cristae formation;GO:0043933 protein-containing complex organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P50945-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50947-1", "uniprot_id": [ { "id": "PHO23_YEAST", "url": "https://www.uniprot.org/uniprot/P50947", "type": "external" } ], "mass": 37024.0, "length": 330, "protein_name": "Transcriptional regulatory protein PHO23", "gene_name": "PHO23", "organism": "Yeast", "refseq_name": "Pho23p", "refseq_ac": [ { "id": "NP_014302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014302", "type": "external" } ], "gene_names_uniprotkb": "PHO23; N2205", "gene_names_refseq": "PHO23", "protein_names_uniprotkb": "Transcriptional regulatory protein PHO23", "protein_names_refseq": "Pho23p", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162); squamous cell carcinoma (Disease Ontology:DOID:1749); carcinoma (Disease Ontology:DOID:305); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YNL097C); (R-SCE-3899300); (R-SCE-6804758); (R-SCE-6811555)", "pathway_count": 4, "publication_count": 21, "publication_id_list": "10805724;11306585;12672825;14562095;14562106;16273108;16286008;16314178;16728974;17322287;18407956;21177495;23749301;24374639;32597660;33229814;33481703;33491328;8701612;8771715;9169873", "class_list": "", "function": "Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W183;Q45TZ9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000118 histone deacetylase complex;GO:0070210 Rpd3L-Expanded complex;GO:0033698 Rpd3L complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0034605 cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P50947-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51402-1", "uniprot_id": [ { "id": "RL37B_YEAST", "url": "https://www.uniprot.org/uniprot/P51402", "type": "external" } ], "mass": 9868.0, "length": 88, "protein_name": "Large ribosomal subunit protein eL37B", "gene_name": "RPL37B", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL37 RPL37B", "refseq_ac": [ { "id": "NP_010788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010788", "type": "external" } ], "gene_names_uniprotkb": "RPL37B; D9719.6; RPL35B", "gene_names_refseq": "RPL37B", "protein_names_uniprotkb": "Large ribosomal subunit protein eL37B; 60S ribosomal protein L37-B; L43; YL35; YP55", "protein_names_refseq": "60S ribosomal protein eL37 RPL37B", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR500C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 11, "publication_id_list": "14562095;14562106;22096102;23749301;24374639;24524803;32597660;33481703;33491328;9169867;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTC2", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0030687 preribosome, large subunit precursor;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P51402-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51601-1", "uniprot_id": [ { "id": "GCH1_YEAST", "url": "https://www.uniprot.org/uniprot/P51601", "type": "external" } ], "mass": 27769.0, "length": 243, "protein_name": "GTP cyclohydrolase 1", "gene_name": "FOL2", "organism": "Yeast", "refseq_name": "GTP cyclohydrolase I", "refseq_ac": [ { "id": "NP_011783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011783", "type": "external" } ], "gene_names_uniprotkb": "FOL2; G9349", "gene_names_refseq": "FOL2", "protein_names_uniprotkb": "GTP cyclohydrolase 1; 3.5.4.16; GTP cyclohydrolase I; GTP-CH-I", "protein_names_refseq": "GTP cyclohydrolase I", "tax_id": 559292, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); dopa-responsive dystonia (Disease Ontology:DOID:0090043); BH4-deficient hyperphenylalaninemia B (Disease Ontology:DOID:0112225); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); sciatic neuropathy (Disease Ontology:DOID:11446); diabetic angiopathy (Disease Ontology:DOID:11713); primary biliary cholangitis (Disease Ontology:DOID:12236); dilated cardiomyopathy (Disease Ontology:DOID:12930); transient cerebral ischemia (Disease Ontology:DOID:224); bipolar disorder (Disease Ontology:DOID:3312); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); pulmonary fibrosis (Disease Ontology:DOID:3770); liver cirrhosis (Disease Ontology:DOID:5082); intestinal disease (Disease Ontology:DOID:5295); dystonia (Disease Ontology:DOID:543); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YGR267C); (R-SCE-1474151)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "14562106;17322287;17330950;17563356;18407956;19779198;21177495;22814378;24374639;32597660;33481703;33491328;7542887;8573145;9169869;9605509", "class_list": "", "function": "GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VV45", "ec_number_list": [ { "id": "3.5.4.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.16", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0003934 GTP cyclohydrolase I activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0046654 tetrahydrofolate biosynthetic process;GO:0006729 tetrahydrobiopterin biosynthetic process;GO:0009396 folic acid-containing compound biosynthetic process;GO:0046656 folic acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P51601-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51862-1", "uniprot_id": [ { "id": "ROM2_YEAST", "url": "https://www.uniprot.org/uniprot/P51862", "type": "external" } ], "mass": 152596.0, "length": 1356, "protein_name": "RHO1 GDP-GTP exchange protein 2", "gene_name": "ROM2", "organism": "Yeast", "refseq_name": "Rho family guanine nucleotide exchange factor ROM2", "refseq_ac": [ { "id": "NP_013475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013475", "type": "external" } ], "gene_names_uniprotkb": "ROM2; L8039.3", "gene_names_refseq": "ROM2", "protein_names_uniprotkb": "RHO1 GDP-GTP exchange protein 2", "protein_names_refseq": "Rho family guanine nucleotide exchange factor ROM2", "tax_id": 559292, "disease": "Charcot-Marie-Tooth disease type 4H (Disease Ontology:DOID:0110192); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); X-linked Aarskog syndrome (Disease Ontology:DOID:6683)", "pathway": " (sce:YLR371W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "17287358;17330950;18407956;19779198;19795423;19823750;20489023;20702584;21126336;22814378;23749301;24374639;32597660;33481703;33491328;34965436;8641285;9169871", "class_list": "", "function": "Stimulates the exchange of RHO1 GDP-bound form into GTP-bound form., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 60, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071944 cell periphery;GO:0032153 cell division site;GO:0000131 incipient cellular bud site", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0045807 positive regulation of endocytosis;GO:0030010 establishment of cell polarity;GO:0060237 regulation of fungal-type cell wall organization;GO:1903338 regulation of cell wall organization or biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P51862-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51979-1", "uniprot_id": [ { "id": "HFM1_YEAST", "url": "https://www.uniprot.org/uniprot/P51979", "type": "external" } ], "mass": 135072.0, "length": 1187, "protein_name": "ATP-dependent DNA helicase MER3", "gene_name": "HFM1", "organism": "Yeast", "refseq_name": "DNA helicase", "refseq_ac": [ { "id": "NP_011263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011263", "type": "external" } ], "gene_names_uniprotkb": "HFM1; MER3; NRE1046", "gene_names_refseq": "HFM1; MER3", "protein_names_uniprotkb": "ATP-dependent DNA helicase MER3; 5.6.2.4; DNA 3'-5' helicase MER3; Protein HFM1", "protein_names_refseq": "DNA helicase", "tax_id": 559292, "disease": "primary ovarian insufficiency 9 (Disease Ontology:DOID:0080866)", "pathway": " (sce:YGL251C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10523314;11376001;11971962;12039965;24374639;33491328;8972578;9169869", "class_list": "", "function": "DNA-dependent ATPase and 3'-5' DNA helicase (PubMed:11376001, PubMed:12039965). Required in the control of double strand break transition and crossover during meiosis (PubMed:10523314, PubMed:11971962). ATPase is slightly better stimulated by single-stranded (ss) than double-stranded (ds)DNA (PubMed:11376001). Unwinds Holliday junction (HJ) DNA to Y-DNA and to ssDNA (PubMed:12039965). Efficient unwinding requires 6 nucleotides of 3'-ssDNA; seems to initiate unwinding from blunt ends when they open slightly (PubMed:12039965). Binds HJ, dsDNA, ssDNA and 3'- and 5-overhang DNA (PubMed:11971962, PubMed:12039965)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV84", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0006260 DNA replication;GO:0007129 homologous chromosome pairing at meiosis;GO:0007131 reciprocal meiotic recombination;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P51979-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51996-1", "uniprot_id": [ { "id": "YPT32_YEAST", "url": "https://www.uniprot.org/uniprot/P51996", "type": "external" } ], "mass": 24520.0, "length": 222, "protein_name": "GTP-binding protein YPT32/YPT11", "gene_name": "YPT32", "organism": "Yeast", "refseq_name": "Rab family GTPase YPT32", "refseq_ac": [ { "id": "NP_011305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011305", "type": "external" } ], "gene_names_uniprotkb": "YPT32; YPT11", "gene_names_refseq": "YPT32", "protein_names_uniprotkb": "GTP-binding protein YPT32/YPT11; Rab GTPase YPT32", "protein_names_refseq": "Rab family GTPase YPT32", "tax_id": 559292, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (sce:YGL210W); (R-SCE-5620912); (R-SCE-8873719)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "10559187;11102533;11785952;11943201;12045183;12478387;14562106;17322287;21126336;23078654;23749301;24374639;33481703;33491328;34965436;8813766;8978673;9151665;9153757;9169869", "class_list": "", "function": "Required for protein transport through the secretory pathway. Probably involved in regulation of secretory vesicle formation at the trans-Golgi compartment. Mediates the proper polarized localization of SEC2, a GEF for SEC4, but does not alter the exchange activity of SEC2 on SEC4. Plays a role in autophagy., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VTU5", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005741 mitochondrial outer membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0015031 protein transport;GO:0006914 autophagy;GO:0016192 vesicle-mediated transport;GO:0006887 exocytosis;GO:0034498 early endosome to Golgi transport", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P51996-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52488-1", "uniprot_id": [ { "id": "UBA2_YEAST", "url": "https://www.uniprot.org/uniprot/P52488", "type": "external" } ], "mass": 71259.0, "length": 636, "protein_name": "Ubiquitin-activating enzyme E1-like", "gene_name": "UBA2", "organism": "Yeast", "refseq_name": "E1 ubiquitin-activating protein UBA2", "refseq_ac": [ { "id": "NP_010678", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010678", "type": "external" } ], "gene_names_uniprotkb": "UBA2; D9509.10; PIP2; UAL1", "gene_names_refseq": "UAL1; UBA2", "protein_names_uniprotkb": "Ubiquitin-activating enzyme E1-like; Polymerase-interacting protein 2; SMT3-activating enzyme subunit 2", "protein_names_refseq": "E1 ubiquitin-activating protein UBA2", "tax_id": 559292, "disease": "hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (sce:YDR390C); (R-SCE-3065676); (R-SCE-3065678)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "14562106;18407956;19779198;23749301;24374639;32597660;33481703;33491328;33502312;7629121;9169867;9312010", "class_list": "", "function": "The dimeric enzyme acts as a SMT3 E1 ligase. It mediates ATP-dependent activation of SMT3 and formation of a thioester with a conserved cysteine residue on AOS1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT24", "ec_number_list": [], "go_molecular_function": "GO:0019948 SUMO activating enzyme activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0031510 SUMO activating enzyme complex;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016925 protein sumoylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P52488-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52489-1", "uniprot_id": [ { "id": "KPYK2_YEAST", "url": "https://www.uniprot.org/uniprot/P52489", "type": "external" } ], "mass": 55195.0, "length": 506, "protein_name": "Pyruvate kinase 2", "gene_name": "PYK2", "organism": "Yeast", "refseq_name": "pyruvate kinase PYK2", "refseq_ac": [ { "id": "NP_014992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014992", "type": "external" } ], "gene_names_uniprotkb": "PYK2; O6342", "gene_names_refseq": "PYK2", "protein_names_uniprotkb": "Pyruvate kinase 2; 2.7.1.40; PK 2", "protein_names_refseq": "pyruvate kinase PYK2", "tax_id": 559292, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); congenital nonspherocytic hemolytic anemia 2 (Disease Ontology:DOID:0111077); hypertension (Disease Ontology:DOID:10763); malaria (Disease Ontology:DOID:12365); Gaucher's disease (Disease Ontology:DOID:1926); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); hyperglycemia (Disease Ontology:DOID:4195); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YOR347C); (R-SCE-6798695); (R-SCE-70171); (R-SCE-70268)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "14562106;20639203;24374639;32597660;33481703;33491328;8948102;9139918;9169874", "class_list": "", "function": "May be used by cells under conditions in which the level of glycolytic flux is very low., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W342", "ec_number_list": [ { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.4.23.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.25", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.7.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.59", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.3.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0030955 potassium ion binding;GO:1904408 melatonin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P52489-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52490-1", "uniprot_id": [ { "id": "UBC13_YEAST", "url": "https://www.uniprot.org/uniprot/P52490", "type": "external" } ], "mass": 17468.0, "length": 153, "protein_name": "Ubiquitin-conjugating enzyme E2 13", "gene_name": "UBC13", "organism": "Yeast", "refseq_name": "E2 ubiquitin-conjugating protein UBC13", "refseq_ac": [ { "id": "NP_010377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010377", "type": "external" } ], "gene_names_uniprotkb": "UBC13; YD6652.04", "gene_names_refseq": "UBC13", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 13; 2.3.2.23; E2 ubiquitin-conjugating enzyme 13; Ubiquitin carrier protein 13; Ubiquitin-protein ligase 13", "protein_names_refseq": "E2 ubiquitin-conjugating protein UBC13", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR092W); (R-SCE-9646399); (R-SCE-983168)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10880451;11440714;14562106;22106047;24374639;25690888;33491328;8576256;9169867", "class_list": "", "function": "Promotes the template-switching (TS) branch of the DNA damage tolerance (DDT) pathway (also known as the post-replication repair (PRR) pathway), that bypasses replication-blocking lesions without removing them (PubMed:25690888). Together with ubiquitin-protein ligase RAD5 and ubiquitin-conjugating enzyme MMS2, synthesizes 'Lys-63'-linked polyubiquitin chains on monoubiquitinated POL30/PCNA, to promote template-switching to the newly synthesized sister chromatid for error-free synthesis past the DNA lesion (PubMed:25690888)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS79", "ec_number_list": [ { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "1.14.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0031371 ubiquitin conjugating enzyme complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0070534 protein K63-linked ubiquitination;GO:0010994 free ubiquitin chain polymerization;GO:0006301 DNA damage tolerance;GO:0044395 protein targeting to vacuolar membrane", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P52490-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52593-1", "uniprot_id": [ { "id": "NU188_YEAST", "url": "https://www.uniprot.org/uniprot/P52593", "type": "external" } ], "mass": 188577.0, "length": 1655, "protein_name": "Nucleoporin NUP188", "gene_name": "NUP188", "organism": "Yeast", "refseq_name": "Nup188p", "refseq_ac": [ { "id": "NP_013604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013604", "type": "external" } ], "gene_names_uniprotkb": "NUP188", "gene_names_refseq": "NUP188", "protein_names_uniprotkb": "Nucleoporin NUP188; Nuclear pore protein NUP188", "protein_names_refseq": "Nup188p", "tax_id": 559292, "disease": "", "pathway": " (sce:YML103C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10684247;12791264;14562106;18407956;21126336;22106047;24374639;33491328;8522578;8682854;8682855;9169872", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP188 probably plays an important role in NPC assembly and organization., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W0I1", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0044611 nuclear pore inner ring", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:0031990 mRNA export from nucleus in response to heat stress;GO:0006405 RNA export from nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P52593-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52871-1", "uniprot_id": [ { "id": "SC6B2_YEAST", "url": "https://www.uniprot.org/uniprot/P52871", "type": "external" } ], "mass": 9606.0, "length": 88, "protein_name": "Protein transport protein SBH2", "gene_name": "SBH2", "organism": "Yeast", "refseq_name": "Arf family guanine nucleotide exchange factor SBH2", "refseq_ac": [ { "id": "NP_010936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010936", "type": "external" } ], "gene_names_uniprotkb": "SBH2; SEB2; YER019BC", "gene_names_refseq": "SBH2; SEB2", "protein_names_uniprotkb": "Protein transport protein SBH2; Ssh1 complex subunit SBH2; Ssh1 complex subunit beta", "protein_names_refseq": "Arf family guanine nucleotide exchange factor SBH2", "tax_id": 559292, "disease": "", "pathway": " (sce:YER019C-A); (R-SCE-9609523)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14562106;17322287;24374639;32597660;33481703;8612571;8740416;9169868", "class_list": "", "function": "Part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein endoplasmic reticulum (ER) import., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLR8;Q53X22", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005784 Sec61 translocon complex;GO:0005637 nuclear inner membrane;GO:0071261 Ssh1 translocon complex", "go_biological_process": "GO:0006614 SRP-dependent cotranslational protein targeting to membrane;GO:0031204 post-translational protein targeting to membrane, translocation;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P52871-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52910-1", "uniprot_id": [ { "id": "ACS2_YEAST", "url": "https://www.uniprot.org/uniprot/P52910", "type": "external" } ], "mass": 75492.0, "length": 683, "protein_name": "Acetyl-coenzyme A synthetase 2", "gene_name": "ACS2", "organism": "Yeast", "refseq_name": "acetate--CoA ligase ACS2", "refseq_ac": [ { "id": "NP_013254", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013254", "type": "external" } ], "gene_names_uniprotkb": "ACS2; L9634.10", "gene_names_refseq": "ACS2", "protein_names_uniprotkb": "Acetyl-coenzyme A synthetase 2; 6.2.1.1; Acetate--CoA ligase 2; Acyl-activating enzyme 2", "protein_names_refseq": "acetate--CoA ligase ACS2", "tax_id": 559292, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); morbid obesity (Disease Ontology:DOID:11981); alcohol use disorder (Disease Ontology:DOID:1574); lymphangioleiomyomatosis (Disease Ontology:DOID:3319)", "pathway": " (sce:YLR153C); (R-SCE-71384)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "12872131;14562095;14562106;16857587;18407956;20190278;23749301;24374639;24909858;33481703;33491328;7649171;8910545;9169871", "class_list": "", "function": "Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. 'Anaerobic' isozyme of acetyl-coenzyme A synthetase, which is required for growth on fermentable carbon sources such as glucose. May be involved in the PDH (pyruvate dehydrogenase complex) bypass., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYE8", "ec_number_list": [ { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016208 AMP binding;GO:0003987 acetate-CoA ligase activity;GO:0016880 acid-ammonia (or amide) ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0006085 acetyl-CoA biosynthetic process;GO:0006090 pyruvate metabolic process;GO:0019427 acetyl-CoA biosynthetic process from acetate;GO:0040029 epigenetic regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P52910-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52919-1", "uniprot_id": [ { "id": "NBP1_YEAST", "url": "https://www.uniprot.org/uniprot/P52919", "type": "external" } ], "mass": 37354.0, "length": 319, "protein_name": "NAP1-binding protein", "gene_name": "NBP1", "organism": "Yeast", "refseq_name": "Nbp1p", "refseq_ac": [ { "id": "NP_013562", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013562", "type": "external" } ], "gene_names_uniprotkb": "NBP1; L9122.6", "gene_names_refseq": "NBP1", "protein_names_uniprotkb": "NAP1-binding protein", "protein_names_refseq": "Nbp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR457C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14562106;16436507;17287358;18407956;19520826;19779198;20702584;21126336;21177495;23749301;24374639;32597660;33229814;33481703;33491328;9169871", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ91", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005637 nuclear inner membrane;GO:0005816 spindle pole body;GO:0005823 central plaque of spindle pole body", "go_biological_process": "GO:0030474 spindle pole body duplication;GO:0070631 spindle pole body localization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P52919-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52920-1", "uniprot_id": [ { "id": "NBP35_YEAST", "url": "https://www.uniprot.org/uniprot/P52920", "type": "external" } ], "mass": 35253.0, "length": 328, "protein_name": "Cytosolic Fe-S cluster assembly factor NBP35", "gene_name": "NBP35", "organism": "Yeast", "refseq_name": "Fe-S cluster-binding ATPase", "refseq_ac": [ { "id": "NP_011424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011424", "type": "external" } ], "gene_names_uniprotkb": "NBP35", "gene_names_refseq": "NBP35", "protein_names_uniprotkb": "Cytosolic Fe-S cluster assembly factor NBP35; Nucleotide-binding protein 35", "protein_names_refseq": "Fe-S cluster-binding ATPase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL091C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;15660135;15667273;15728363;17401378;22362766;24374639;33491328;8921898;9169869;9290212", "class_list": "", "function": "Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU54", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0005524 ATP binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016887 ATP hydrolysis activity;GO:0051536 iron-sulfur cluster binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1904564 cytosolic [4Fe-4S] assembly scaffold complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0002098 tRNA wobble uridine modification", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P52920-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52960-1", "uniprot_id": [ { "id": "PIP2_YEAST", "url": "https://www.uniprot.org/uniprot/P52960", "type": "external" } ], "mass": 114711.0, "length": 996, "protein_name": "Peroxisome proliferation transcriptional regulator", "gene_name": "PIP2", "organism": "Yeast", "refseq_name": "oleate-activated transcription factor PIP2", "refseq_ac": [ { "id": "NP_015008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015008", "type": "external" } ], "gene_names_uniprotkb": "PIP2; OAF2", "gene_names_refseq": "OAF2; PIP2", "protein_names_uniprotkb": "Peroxisome proliferation transcriptional regulator; Oleate-activated transcription factor 2", "protein_names_refseq": "oleate-activated transcription factor PIP2", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR363C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10428786;12709061;17467953;21126336;24374639;29550802;33491328;8670793;8972187;9169874;9288897", "class_list": "", "function": "The PIP2-OAF1 heterodimer acts as a transcriptional activator to induce the transcription of genes encoding proteins involved in fatty acid beta-oxidation, a response called oleic acid induction, when cells grow on fatty acids as sole carbon source. Recognizes and binds to the oleate response element (ORE) (or peroxisome box), two inverted CGG triplets spaced by 14 to 18 intervening nucleotides, in the promoter region of a number of genes (such as CTA1, FOX1 to FOX3, FAA2, PAS8, PAS10, etc.) for peroxisomal proteins. Activity is inhibited by OAF1 under non-inducing conditions. Activity is repressed by glucose., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W358", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0089716 Pip2-Oaf1 complex", "go_biological_process": "GO:0071400 cellular response to oleic acid;GO:0006351 DNA-templated transcription;GO:0006631 fatty acid metabolic process;GO:0032000 positive regulation of fatty acid beta-oxidation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P52960-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53008-1", "uniprot_id": [ { "id": "CWH41_YEAST", "url": "https://www.uniprot.org/uniprot/P53008", "type": "external" } ], "mass": 96507.0, "length": 833, "protein_name": "Mannosyl-oligosaccharide glucosidase", "gene_name": "CWH41", "organism": "Yeast", "refseq_name": "mannosyl-oligosaccharide glucosidase", "refseq_ac": [ { "id": "NP_011488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011488", "type": "external" } ], "gene_names_uniprotkb": "CWH41; GLS1", "gene_names_refseq": "CWH41; DER7; GLS1", "protein_names_uniprotkb": "Mannosyl-oligosaccharide glucosidase; 3.2.1.106; Glucosidase I; Processing A-glucosidase I", "protein_names_refseq": "mannosyl-oligosaccharide glucosidase", "tax_id": 559292, "disease": "congenital disorder of glycosylation type IIb (Disease Ontology:DOID:0070254)", "pathway": " (sce:YGL027C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;21126336;23536181;24374639;8576053;9169869;9363442", "class_list": "glycogene;glycosylhydrolase", "function": "Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor highly specifically (PubMed:9363442). Seems to play a role in beta-1,6-glucan synthesis (PubMed:8576053)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VUB1", "ec_number_list": [ { "id": "3.2.1.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.106", "type": "external" } ], "go_molecular_function": "GO:0004573 Glc3Man9GlcNAc2 oligosaccharide glucosidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0009311 oligosaccharide metabolic process;GO:0009272 fungal-type cell wall biogenesis;GO:0070880 fungal-type cell wall beta-glucan biosynthetic process;GO:0140277 endoplasmic reticulum N-glycan trimming", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P53008-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000010001.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53011-1", "uniprot_id": [ { "id": "SEH1_YEAST", "url": "https://www.uniprot.org/uniprot/P53011", "type": "external" } ], "mass": 39123.0, "length": 349, "protein_name": "Nucleoporin SEH1", "gene_name": "SEH1", "organism": "Yeast", "refseq_name": "Seh1p", "refseq_ac": [ { "id": "NP_011415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011415", "type": "external" } ], "gene_names_uniprotkb": "SEH1", "gene_names_refseq": "SEH1", "protein_names_uniprotkb": "Nucleoporin SEH1; Nuclear pore protein SEH1; SEC13 homolog 1", "protein_names_refseq": "Seh1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL100W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10684247;11823431;12206772;12791264;14562106;17322287;18407956;19779198;21126336;21454883;24374639;33491328;34965436;8565072;9169869", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Involved in nuclear poly(A)+ RNA export and NPC biogenesis. It is also required for normal nuclear morphology. Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU45", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0005774 vacuolar membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006913 nucleocytoplasmic transport;GO:0015031 protein transport;GO:0034198 cellular response to amino acid starvation;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P53011-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53012-1", "uniprot_id": [ { "id": "SCS3_YEAST", "url": "https://www.uniprot.org/uniprot/P53012", "type": "external" } ], "mass": 42735.0, "length": 380, "protein_name": "Acyl-coenzyme A diphosphatase SCS3", "gene_name": "SCS3", "organism": "Yeast", "refseq_name": "Scs3p", "refseq_ac": [ { "id": "NP_011389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011389", "type": "external" } ], "gene_names_uniprotkb": "SCS3; FIT2B; G2868", "gene_names_refseq": "FIT2B; SCS3", "protein_names_uniprotkb": "Acyl-coenzyme A diphosphatase SCS3; 3.6.1.-; FIT family protein SCS3", "protein_names_refseq": "Scs3p", "tax_id": 559292, "disease": "Siddiqi syndrome (Disease Ontology:DOID:0081273); lipid metabolism disorder (Disease Ontology:DOID:3146)", "pathway": " (sce:YGL126W); (R-SCE-8964572)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14562106;16847258;17322287;24374639;26504167;29417057;29526591;32915949;7706223;8896269;9169869", "class_list": "", "function": "Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity) (PubMed:26504167, PubMed:29526591, PubMed:32915949). May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity) (PubMed:29526591). May play a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Involved in phospholipid biosynthesis (By similarity) (PubMed:29417057, PubMed:32915949, PubMed:7706223)., [UniProtKB, PubMed, UniProtKB, HAMAP, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU22;E9P8W2", "ec_number_list": [ { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;GO:0010945 coenzyme A diphosphatase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0055091 phospholipid homeostasis;GO:0019915 lipid storage;GO:0006644 phospholipid metabolic process;GO:0034389 lipid droplet organization;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53012-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53035-1", "uniprot_id": [ { "id": "MIG2_YEAST", "url": "https://www.uniprot.org/uniprot/P53035", "type": "external" } ], "mass": 42048.0, "length": 382, "protein_name": "Regulatory protein MIG2", "gene_name": "MIG2", "organism": "Yeast", "refseq_name": "Mig2p", "refseq_ac": [ { "id": "NP_011306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011306", "type": "external" } ], "gene_names_uniprotkb": "MIG2; MLZ1", "gene_names_refseq": "MIG2; MLZ1", "protein_names_uniprotkb": "Regulatory protein MIG2", "protein_names_refseq": "Mig2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL209W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;24374639;33491328;8756637;8813766;9153757;9169869", "class_list": "", "function": "Involved in glucose repression of the SUC2 gene., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTU6;O11853;O11854", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1900436 positive regulation of filamentous growth of a population of unicellular organisms in response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P53035-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53037-1", "uniprot_id": [ { "id": "PSD2_YEAST", "url": "https://www.uniprot.org/uniprot/P53037", "type": "external" } ], "mass": 130065.0, "length": 1138, "protein_name": "Phosphatidylserine decarboxylase proenzyme 2", "gene_name": "PSD2", "organism": "Yeast", "refseq_name": "phosphatidylserine decarboxylase 2", "refseq_ac": [ { "id": "NP_011686", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011686", "type": "external" } ], "gene_names_uniprotkb": "PSD2", "gene_names_refseq": "PSD2", "protein_names_uniprotkb": "Phosphatidylserine decarboxylase proenzyme 2; 4.1.1.65", "protein_names_refseq": "phosphatidylserine decarboxylase 2", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR170W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11104779;11294902;12093819;18407956;20016005;21177495;23749301;24366873;24374639;30510114;32597660;33229814;33481703;33491328;7890739;7890740;9169869;9290212", "class_list": "", "function": "Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (PubMed:24366873, PubMed:7890739, PubMed:7890740). Phosphatidylethanolamine produced by PSD2 is insufficient to completely provide the PtdEtn pool required by mitochondria under respiratory conditions (PubMed:11294902). PSD2 is also involved in the PtdSer transport step to the site of PtdEtn synthesis on the Golgi/endosome membranes (PubMed:24366873). Required for normal heavy metal resistance (PubMed:20016005)., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 14, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 14, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 14, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "D6VUV4", "ec_number_list": [ { "id": "4.1.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.65", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004609 phosphatidylserine decarboxylase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0010008 endosome membrane;GO:0005795 Golgi stack", "go_biological_process": "GO:0006656 phosphatidylcholine biosynthetic process;GO:0016540 protein autoprocessing;GO:0006646 phosphatidylethanolamine biosynthetic process;GO:0120010 intermembrane phospholipid transfer", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P53037-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53038-1", "uniprot_id": [ { "id": "TEL2_YEAST", "url": "https://www.uniprot.org/uniprot/P53038", "type": "external" } ], "mass": 78687.0, "length": 688, "protein_name": "Telomere length regulation protein TEL2", "gene_name": "TEL2", "organism": "Yeast", "refseq_name": "Tel2p", "refseq_ac": [ { "id": "NP_011613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011613", "type": "external" } ], "gene_names_uniprotkb": "TEL2", "gene_names_refseq": "TEL2", "protein_names_uniprotkb": "Telomere length regulation protein TEL2", "protein_names_refseq": "Tel2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR099W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;19779198;20801936;24374639;33491328;8649421;9169869", "class_list": "", "function": "Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins (By similarity). Required for telomere length regulation and telomere position effect. Regulates telomere length and participates in gene silencing at subtelomeric regions. Binds to telomeric DNA repeats., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUN1", "ec_number_list": [], "go_molecular_function": "GO:0042162 telomeric DNA binding;GO:0051879 Hsp90 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000781 chromosome, telomeric region;GO:0110078 TTT Hsp90 cochaperone complex", "go_biological_process": "GO:0051083 'de novo' cotranslational protein folding;GO:0000723 telomere maintenance;GO:0050821 protein stabilization;GO:2000003 positive regulation of DNA damage checkpoint;GO:0034502 protein localization to chromosome", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P53038-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53048-1", "uniprot_id": [ { "id": "MAL11_YEAST", "url": "https://www.uniprot.org/uniprot/P53048", "type": "external" } ], "mass": 67980.0, "length": 616, "protein_name": "General alpha-glucoside permease", "gene_name": "MAL11", "organism": "Yeast", "refseq_name": "alpha-glucoside permease", "refseq_ac": [ { "id": "NP_011805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011805", "type": "external" } ], "gene_names_uniprotkb": "MAL11; AGT1; MAL1T; MTP1", "gene_names_refseq": "AGT1; MAL11", "protein_names_uniprotkb": "General alpha-glucoside permease; Maltose permease MAL11; Maltose transport protein MAL11", "protein_names_refseq": "alpha-glucoside permease", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR289C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10618490;12210897;16847258;24374639;8594329;9090054;9169869", "class_list": "", "function": "High-affinity uptake of alpha-glucosides such as maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose, melezitose and glucose. Acts with the concomitant transport of protons into the cell (symport system)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VV66", "ec_number_list": [], "go_molecular_function": "GO:0005351 carbohydrate:proton symporter activity;GO:0015574 trehalose transmembrane transporter activity;GO:0005352 alpha-glucoside:proton symporter activity;GO:0005364 maltose:proton symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0008643 carbohydrate transport;GO:0000023 maltose metabolic process;GO:0000017 alpha-glucoside transport;GO:0015771 trehalose transport;GO:0015768 maltose transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P53048-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53049-1", "uniprot_id": [ { "id": "YOR1_YEAST", "url": "https://www.uniprot.org/uniprot/P53049", "type": "external" } ], "mass": 166728.0, "length": 1477, "protein_name": "Oligomycin resistance ATP-dependent permease YOR1", "gene_name": "YOR1", "organism": "Yeast", "refseq_name": "ATP-binding cassette transporter YOR1", "refseq_ac": [ { "id": "NP_011797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011797", "type": "external" } ], "gene_names_uniprotkb": "YOR1; YRS1", "gene_names_refseq": "YOR1; YRS1", "protein_names_uniprotkb": "Oligomycin resistance ATP-dependent permease YOR1; 7.2.2.2; 7.6.2.3; ABC transporter YOR1; ABC-type Cd(2+) transporter; ABC-type glutathione-S-conjugate transporter; Yeast oligomycin resistance protein 1", "protein_names_refseq": "ATP-binding cassette transporter YOR1", "tax_id": 559292, "disease": "cystic fibrosis (Disease Ontology:DOID:1485); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (sce:YGR281W); (R-SCE-114608); (R-SCE-382556); (R-SCE-8856825); (R-SCE-9748787); (R-SCE-9753281)", "pathway_count": 6, "publication_count": 29, "publication_id_list": "10082567;12107161;12529331;14562106;15665377;16814918;16847258;17287358;17330950;17615300;17950691;18407956;19684113;19779198;19795423;19823750;20702584;21126336;22218487;23749301;24374639;32597660;33481703;33491328;8524254;8663018;9090054;9169869;9575223", "class_list": "", "function": "Functions as a pleiotropic drug pump at the plasma membrane to clear toxic substances from the cytosol. Organic anion transporter involved in the detoxification of a wide range of toxic environmental organic anions that contain carboxyl groups (PubMed:8663018). Required for tolerance to reveromycin A, tautomycin and leptomycin B (PubMed:8663018). Required for oligomycin resistance (PubMed:10082567, PubMed:8524254). Required for rhodamine B resistance. Mediates the ATP-dependent efflux of rhodamine B (PubMed:9575223). Involved in cadmium detoxification. Displays an energy-dependent efflux of cadmium and glutathione, suggesting that YOR1 transports both compounds as a bis-glutathionato-cadmium Cd-(GS)(2) complex (PubMed:16814918). Confers resistance to rhodamine 6G and to doxorubicin (PubMed:17950691)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VV58", "ec_number_list": [ { "id": "7.2.2.21", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.21", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.2.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity;GO:0015431 ABC-type glutathione S-conjugate transporter activity;GO:0015434 ABC-type cadmium transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0055085 transmembrane transport;GO:0042908 xenobiotic transport", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P53049-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53051-1", "uniprot_id": [ { "id": "MALX3_YEAST", "url": "https://www.uniprot.org/uniprot/P53051", "type": "external" } ], "mass": 68592.0, "length": 589, "protein_name": "Oligo-1,6-glucosidase IMA1", "gene_name": "IMA1", "organism": "Yeast", "refseq_name": "oligo-1,6-glucosidase IMA1", "refseq_ac": [ { "id": "NP_011803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011803", "type": "external" } ], "gene_names_uniprotkb": "IMA1", "gene_names_refseq": "IMA1", "protein_names_uniprotkb": "Oligo-1,6-glucosidase IMA1; 3.2.1.10; Alpha-glucosidase; Isomaltase 1", "protein_names_refseq": "oligo-1,6-glucosidase IMA1", "tax_id": 559292, "disease": "cystinuria (Disease Ontology:DOID:9266)", "pathway": " (sce:YGR287C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;14576278;15291818;20562106;20812985;24374639;9090054;9169869", "class_list": "glycogene;glycosylhydrolase", "function": "Major isomaltase (alpha-1,6-glucosidase) required for isomaltose utilization. Preferentially hydrolyzes isomaltose, palatinose, and methyl-alpha-glucoside, with little activity towards isomaltotriose or longer oligosaccharides. Does not hydrolyze maltose., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV64;Q76CZ0", "ec_number_list": [], "go_molecular_function": "GO:0004558 alpha-1,4-glucosidase activity;GO:0004556 alpha-amylase activity;GO:0004574 oligo-1,6-glucosidase activity;GO:0004575 sucrose alpha-glucosidase activity;GO:0033934 glucan 1,4-alpha-maltotriohydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0000025 maltose catabolic process;GO:0005987 sucrose catabolic process;GO:0046352 disaccharide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P53051-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53061-1", "uniprot_id": [ { "id": "ZIP2_YEAST", "url": "https://www.uniprot.org/uniprot/P53061", "type": "external" } ], "mass": 82816.0, "length": 704, "protein_name": "Protein ZIP2", "gene_name": "ZIP2", "organism": "Yeast", "refseq_name": "Zip2p", "refseq_ac": [ { "id": "NP_011265", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011265", "type": "external" } ], "gene_names_uniprotkb": "ZIP2; NRC704", "gene_names_refseq": "ZIP2", "protein_names_uniprotkb": "Protein ZIP2; Zipping up meiotic chromosomes protein 2", "protein_names_refseq": "Zip2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL249W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10319812;10848609;10943844;11454751;15035982;15805472;16740482;21177495;24374639;8972578;9169869;9590170", "class_list": "", "function": "Required for initiation of meiotic chromosome synapsis. Involved in synaptonemal complex formation, a structure that tethers a pair of homologous chromosomes along their lengths and plays a central role in recombination and homolog segregation during meiosis. Required for the normal localization of MSH4 to chromosomes., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV86", "ec_number_list": [], "go_molecular_function": "GO:0000166 nucleotide binding;GO:0000217 DNA secondary structure binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005739 mitochondrion;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0016925 protein sumoylation;GO:0007130 synaptonemal complex assembly;GO:0033235 positive regulation of protein sumoylation;GO:0007129 homologous chromosome pairing at meiosis;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P53061-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53063-1", "uniprot_id": [ { "id": "DXO_YEAST", "url": "https://www.uniprot.org/uniprot/P53063", "type": "external" } ], "mass": 44510.0, "length": 387, "protein_name": "Decapping nuclease RAI1", "gene_name": "RAI1", "organism": "Yeast", "refseq_name": "decapping nuclease", "refseq_ac": [ { "id": "NP_011268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011268", "type": "external" } ], "gene_names_uniprotkb": "RAI1; NRE387", "gene_names_refseq": "RAI1", "protein_names_uniprotkb": "Decapping nuclease RAI1; 3.6.1.-; DeNADding enzyme RAI1; NAD-capped RNA hydrolase RAI1; RAT1-interacting protein; ScRai1", "protein_names_refseq": "decapping nuclease", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL246C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10805743;12612077;12897126;14562106;15565157;16131592;17322287;18407956;20802481;22814378;23749301;24374639;26101253;32597660;33491328;8972578;9169869", "class_list": "", "function": "Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (By similarity). The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs (PubMed:12897126, PubMed:20802481, PubMed:26101253). Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (PubMed:12897126, PubMed:20802481). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (PubMed:20802481). Stimulates exoribonuclease activity of RAT1, allowing it to degrade RNAs with stable secondary structure more effectively (PubMed:20802481). Required for the processing of nuclear mRNA and rRNA precursors (PubMed:10805743, PubMed:12612077, PubMed:16131592). May promote termination of transcription by RNA polymerase II (PubMed:15565157)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV89", "ec_number_list": [ { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" } ], "go_molecular_function": "GO:0034353 mRNA 5'-diphosphatase activity;GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006397 mRNA processing;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P53063-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53076-1", "uniprot_id": [ { "id": "VID30_YEAST", "url": "https://www.uniprot.org/uniprot/P53076", "type": "external" } ], "mass": 108179.0, "length": 958, "protein_name": "GID complex subunit 1", "gene_name": "VID30", "organism": "Yeast", "refseq_name": "glucose-induced degradation complex subunit VID30", "refseq_ac": [ { "id": "NP_011287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011287", "type": "external" } ], "gene_names_uniprotkb": "VID30; GID1", "gene_names_refseq": "GID1; VID30", "protein_names_uniprotkb": "GID complex subunit 1; Glucose-induced degradation protein 1; Vacuolar import and degradation protein 30", "protein_names_refseq": "glucose-induced degradation complex subunit VID30", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL227W)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "11356843;12686616;14562095;14562106;16872538;17563356;18407956;18508925;19779198;20702584;21126336;22645139;22814378;23749301;24374639;28126757;31708416;32597660;33229814;33481703;33491328;33905682;35650207;9169869;9737955", "class_list": "", "function": "Component of the GID E3 ligase complex recruiting N termini and catalyzing ubiquitination of proteins targeted for degradation. GID E3 is regulated through assembly with interchangeable N-degron-binding substrate receptors induced by distinct environmental perturbations (PubMed:31708416). Required for the adaptation to the presence of glucose in the growth medium; mediates in association with the substrate receptor VID24/GID4 the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616, PubMed:31708416, PubMed:9737955). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1), malate dehydrogenase (MDH2), and other gluconeogenic enzymes (PubMed:12686616, PubMed:22645139, PubMed:28126757, PubMed:9737955)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 23, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6VVA7", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0034657 GID complex", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045721 negative regulation of gluconeogenesis;GO:0006808 regulation of nitrogen utilization", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P53076-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53079-1", "uniprot_id": [ { "id": "COG1_YEAST", "url": "https://www.uniprot.org/uniprot/P53079", "type": "external" } ], "mass": 48337.0, "length": 417, "protein_name": "Conserved oligomeric Golgi complex subunit 1", "gene_name": "COG1", "organism": "Yeast", "refseq_name": "Golgi transport complex subunit COG1", "refseq_ac": [ { "id": "NP_011292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011292", "type": "external" } ], "gene_names_uniprotkb": "COG1; COD3; SEC36; TFI1", "gene_names_refseq": "COD3; COG1; LDB11; SEC36", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 1; COG complex subunit 1; Complexed with DOR1 protein 3; Component of oligomeric Golgi complex 1; Protein SEC36", "protein_names_refseq": "Golgi transport complex subunit COG1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL223C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11703943;12006647;12011112;14562106;15047703;17322287;17563356;19779198;22814378;24374639;33481703;33491328;9169869;9290212", "class_list": "", "function": "Acts as essential component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVB2", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0007030 Golgi organization;GO:0000301 retrograde transport, vesicle recycling within Golgi;GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P53079-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53082-1", "uniprot_id": [ { "id": "BOL2_YEAST", "url": "https://www.uniprot.org/uniprot/P53082", "type": "external" } ], "mass": 14102.0, "length": 120, "protein_name": "BolA-like protein 2", "gene_name": "BOL2", "organism": "Yeast", "refseq_name": "Bol2p", "refseq_ac": [ { "id": "NP_011295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011295", "type": "external" } ], "gene_names_uniprotkb": "BOL2; AIM15; FRA2", "gene_names_refseq": "AIM15; BOL2; FRA2", "protein_names_uniprotkb": "BolA-like protein 2; Altered inheritance rate of mitochondria protein 15; Fe repressor of activation 2", "protein_names_refseq": "Bol2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL220W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;17322287;18281282;19300474;24374639;9169869;9290212", "class_list": "", "function": "Involved in the regulation of the iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis. May be involved in mitochondrial organization and biogenesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVB5", "ec_number_list": [], "go_molecular_function": "GO:0051537 2 iron, 2 sulfur cluster binding;GO:0051536 iron-sulfur cluster binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006879 intracellular iron ion homeostasis;GO:0071281 cellular response to iron ion;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P53082-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53083-1", "uniprot_id": [ { "id": "MDM34_YEAST", "url": "https://www.uniprot.org/uniprot/P53083", "type": "external" } ], "mass": 51990.0, "length": 459, "protein_name": "Mitochondrial distribution and morphology protein 34", "gene_name": "MDM34", "organism": "Yeast", "refseq_name": "ERMES complex subunit MDM34", "refseq_ac": [ { "id": "NP_011296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011296", "type": "external" } ], "gene_names_uniprotkb": "MDM34; MMM2", "gene_names_refseq": "MDM34; MMM2", "protein_names_uniprotkb": "Mitochondrial distribution and morphology protein 34; Mitochondrial outer membrane protein MMM2", "protein_names_refseq": "ERMES complex subunit MDM34", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL219C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11907266;14562095;14562106;14981098;16407407;16823961;18775025;19556461;22106047;23749301;24374639;27469264;32597660;33481703;33491328;9169869;9290212", "class_list": "", "function": "Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria (PubMed:11907266, PubMed:14981098). Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria (PubMed:27469264). MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10 (By similarity) (PubMed:19556461)., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTT9", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site;GO:0032865 ERMES complex", "go_biological_process": "GO:0015914 phospholipid transport;GO:0055091 phospholipid homeostasis;GO:0007005 mitochondrion organization;GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P53083-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53086-1", "uniprot_id": [ { "id": "KIP3_YEAST", "url": "https://www.uniprot.org/uniprot/P53086", "type": "external" } ], "mass": 91090.0, "length": 805, "protein_name": "Kinesin-like protein KIP3", "gene_name": "KIP3", "organism": "Yeast", "refseq_name": "tubulin-dependent ATPase KIP3", "refseq_ac": [ { "id": "NP_011299", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011299", "type": "external" } ], "gene_names_uniprotkb": "KIP3", "gene_names_refseq": "KIP3", "protein_names_uniprotkb": "Kinesin-like protein KIP3", "protein_names_refseq": "tubulin-dependent ATPase KIP3", "tax_id": 559292, "disease": "stomach cancer (Disease Ontology:DOID:10534); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YGL216W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;18407956;23001566;23749301;24374639;33491328;9169869;9290212", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTU0", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0008574 plus-end-directed microtubule motor activity;GO:0070463 tubulin-dependent ATPase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005871 kinesin complex;GO:0000776 kinetochore;GO:0005876 spindle microtubule", "go_biological_process": "GO:0007079 mitotic chromosome movement towards spindle pole;GO:0099606 microtubule plus-end directed mitotic chromosome migration;GO:0070462 plus-end specific microtubule depolymerization;GO:0090307 mitotic spindle assembly;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P53086-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53088-1", "uniprot_id": [ { "id": "CTU1_YEAST", "url": "https://www.uniprot.org/uniprot/P53088", "type": "external" } ], "mass": 39987.0, "length": 359, "protein_name": "Cytoplasmic tRNA 2-thiolation protein 1", "gene_name": "NCS6", "organism": "Yeast", "refseq_name": "Ncs6p", "refseq_ac": [ { "id": "NP_011304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011304", "type": "external" } ], "gene_names_uniprotkb": "NCS6; CTU1; TUC1; YGL210W-A", "gene_names_refseq": "NCS6; TUC1; YGL210W-A", "protein_names_uniprotkb": "Cytoplasmic tRNA 2-thiolation protein 1; 2.7.7.-; Cytoplasmic tRNA adenylyltransferase 1; Needs CLA4 to survive protein 6; Thiolation of uridine in cytoplasmic tRNA protein 1", "protein_names_refseq": "Ncs6p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL211W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "12844361;14551258;14562095;17592039;18332122;18664566;18755837;19145231;19151091;19795423;19823750;23749301;24374639;32597660;33481703;33491328;8813766;9153757;9169869", "class_list": "", "function": "Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. May also be involved in protein urmylation and in invasive and pseudohyphal growth., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTU4;Q92322", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005829 cytosol;GO:0002144 cytosolic tRNA wobble base thiouridylase complex", "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation;GO:0034227 tRNA thio-modification;GO:0002098 tRNA wobble uridine modification;GO:0032447 protein urmylation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P53088-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53090-1", "uniprot_id": [ { "id": "ARO8_YEAST", "url": "https://www.uniprot.org/uniprot/P53090", "type": "external" } ], "mass": 56178.0, "length": 500, "protein_name": "Aromatic/aminoadipate aminotransferase 1", "gene_name": "ARO8", "organism": "Yeast", "refseq_name": "bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase", "refseq_ac": [ { "id": "NP_011313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011313", "type": "external" } ], "gene_names_uniprotkb": "ARO8", "gene_names_refseq": "ARO8", "protein_names_uniprotkb": "Aromatic/aminoadipate aminotransferase 1; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; 2.6.1.39; 2.6.1.57; AadAT; Alpha-aminoadipate aminotransferase; Aromatic amino acid aminotransferase 1; Aromatic amino acid aminotransferase I; Aromatic amino acid-requiring protein 8", "protein_names_refseq": "bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL202W); (R-SCE-71064); (R-SCE-71240)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "14562095;14562106;17287358;17322287;18407956;18625006;21126336;21982920;22814378;23893908;24374639;32597660;33229814;33481703;33491328;6763508;9169869;9491082;9491083", "class_list": "", "function": "General aromatic amino acid transaminase involved in several otherwise unrelated metabolic pathways. Responsible for phenylalanine and tyrosine biosynthesis. Active with glutamate, phenylalanine, tyrosine and tryptophan as amino donors and with phenylpyruvate, hydroxyphenylpyruvate, 2-oxoglutarate and pyruvate as amino acceptors. Also active with methionine, alpha-aminoadipate and leucine as amino donors when phenylpyruvate is the amino acceptor and in the reverse reactions with the corresponding oxo acids and phenylalanine as amino donor. Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using aromatic amino acids (tyrosine, phenylalanine and tryptophan) as the amino donors. Catalyzes the formation of alpha-aminoadipate from alpha-ketoadipate in the lysine biosyntheic pathway., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VTV2", "ec_number_list": [ { "id": "2.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.7", "type": "external" }, { "id": "2.6.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.57", "type": "external" }, { "id": "2.6.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.39", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0047536 2-aminoadipate transaminase activity;GO:0008793 aromatic-amino-acid transaminase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006571 tyrosine biosynthetic process;GO:0019878 lysine biosynthetic process via aminoadipic acid;GO:0019509 L-methionine salvage from methylthioadenosine;GO:0009072 aromatic amino acid metabolic process;GO:0009074 aromatic amino acid family catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P53090-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53095-1", "uniprot_id": [ { "id": "DSD1_YEAST", "url": "https://www.uniprot.org/uniprot/P53095", "type": "external" } ], "mass": 47828.0, "length": 428, "protein_name": "D-serine dehydratase", "gene_name": "DSD1", "organism": "Yeast", "refseq_name": "D-serine ammonia-lyase DSD1", "refseq_ac": [ { "id": "NP_011319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011319", "type": "external" } ], "gene_names_uniprotkb": "DSD1; G1315", "gene_names_refseq": "DSD1", "protein_names_uniprotkb": "D-serine dehydratase; 4.3.1.18; D-serine deaminase; DSD", "protein_names_refseq": "D-serine ammonia-lyase DSD1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL196W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12748633;17322287;17869212;17937657;24374639;33491328;9046087;9169869", "class_list": "", "function": "Catalyzes the conversion of D-serine to pyruvate and ammonia (PubMed:17869212, PubMed:17937657). May play a role in D-serine detoxification (PubMed:17869212, PubMed:17937657)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTV7", "ec_number_list": [ { "id": "4.3.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.1.18", "type": "external" } ], "go_molecular_function": "GO:0008721 D-serine ammonia-lyase activity;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0036088 D-serine catabolic process;GO:0070178 D-serine metabolic process;GO:0009636 response to toxic substance", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P53095-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53101-1", "uniprot_id": [ { "id": "STR3_YEAST", "url": "https://www.uniprot.org/uniprot/P53101", "type": "external" } ], "mass": 51828.0, "length": 465, "protein_name": "Cystathionine beta-lyase", "gene_name": "STR3", "organism": "Yeast", "refseq_name": "cystathionine beta-lyase STR3", "refseq_ac": [ { "id": "NP_011331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011331", "type": "external" } ], "gene_names_uniprotkb": "STR3; G1601", "gene_names_refseq": "STR3", "protein_names_uniprotkb": "Cystathionine beta-lyase; 4.4.1.13; Beta-cystathionase; CBL; Cysteine lyase; Cysteine-S-conjugate beta-lyase; Sulfur transfer protein 3", "protein_names_refseq": "cystathionine beta-lyase STR3", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL184C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10821189;14562095;20702584;24374639;33491328;9046087;9169869", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTX0", "ec_number_list": [ { "id": "4.4.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.13", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0016846 carbon-sulfur lyase activity;GO:0047804 cysteine-S-conjugate beta-lyase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome", "go_biological_process": "GO:0009086 methionine biosynthetic process;GO:0019346 transsulfuration;GO:0071266 'de novo' L-methionine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P53101-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53108-1", "uniprot_id": [ { "id": "YIP5_YEAST", "url": "https://www.uniprot.org/uniprot/P53108", "type": "external" } ], "mass": 34843.0, "length": 310, "protein_name": "Protein YIP5", "gene_name": "YIP5", "organism": "Yeast", "refseq_name": "Yip5p", "refseq_ac": [ { "id": "NP_011354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011354", "type": "external" } ], "gene_names_uniprotkb": "YIP5; G1832", "gene_names_refseq": "YIP5", "protein_names_uniprotkb": "Protein YIP5; YPT-interacting protein 5", "protein_names_refseq": "Yip5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL161C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11943201;14562106;15263065;17178117;17322287;19779198;24374639;33481703;33491328;8585324;9169869", "class_list": "", "function": "Possible role in vesicle-mediated transport. May be involved in proper membrane localization of Rab GTPases., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTZ0", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53108-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53109-1", "uniprot_id": [ { "id": "AIM14_YEAST", "url": "https://www.uniprot.org/uniprot/P53109", "type": "external" } ], "mass": 65840.0, "length": 570, "protein_name": "Probable metalloreductase AIM14", "gene_name": "AIM14", "organism": "Yeast", "refseq_name": "putative metalloreductase", "refseq_ac": [ { "id": "NP_011355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011355", "type": "external" } ], "gene_names_uniprotkb": "AIM14; G1837", "gene_names_refseq": "AIM14; YNO1", "protein_names_uniprotkb": "Probable metalloreductase AIM14; 1.16.1.-; Altered inheritance of mitochondria protein 14", "protein_names_refseq": "putative metalloreductase", "tax_id": 559292, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); primary bacterial infectious disease (Disease Ontology:DOID:0050338); renal fibrosis (Disease Ontology:DOID:0050855); X-linked chronic granulomatous disease (Disease Ontology:DOID:0070195); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); immunodeficiency 34 (Disease Ontology:DOID:0112000); thyroid dyshormonogenesis 6 (Disease Ontology:DOID:0112189); hypertension (Disease Ontology:DOID:10763); hypothyroidism (Disease Ontology:DOID:1459); cholera (Disease Ontology:DOID:1498); chronic granulomatous disease (Disease Ontology:DOID:3265); primary hyperaldosteronism (Disease Ontology:DOID:446); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); phenylketonuria (Disease Ontology:DOID:9281); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YGL160W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16702403;16847258;19300474;22814378;24374639;33491328;8585324;9169869", "class_list": "", "function": "Probable cell surface metalloreductase. May be involved in iron or copper homeostasis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTZ1", "ec_number_list": [], "go_molecular_function": "GO:0000293 ferric-chelate reductase activity;GO:0016175 superoxide-generating NAD(P)H oxidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0097038 perinuclear endoplasmic reticulum", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0006915 apoptotic process;GO:0033212 iron import into cell", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P53109-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53115-1", "uniprot_id": [ { "id": "INO80_YEAST", "url": "https://www.uniprot.org/uniprot/P53115", "type": "external" } ], "mass": 171455.0, "length": 1489, "protein_name": "Chromatin-remodeling ATPase INO80", "gene_name": "INO80", "organism": "Yeast", "refseq_name": "chromatin-remodeling ATPase INO80", "refseq_ac": [ { "id": "NP_011365", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011365", "type": "external" } ], "gene_names_uniprotkb": "INO80; G1880", "gene_names_refseq": "INO80", "protein_names_uniprotkb": "Chromatin-remodeling ATPase INO80; 3.6.4.-; Inositol-requiring protein 80", "protein_names_refseq": "chromatin-remodeling ATPase INO80", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL150C)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10077188;10361278;10952318;12434012;12887900;14562095;14562106;15607974;15607975;17287358;17330950;18407956;19779198;19795423;19823750;20190278;20702584;21126336;23749301;24374639;24909858;32597660;33229814;33481703;33491328;8585324;9046099;9169869", "class_list": "", "function": "ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair (PubMed:10952318, PubMed:12887900). Its ability to induce transcription of some phosphate-responsive genes is modulated by inositol polyphosphates (PubMed:10361278, PubMed:10952318). The INO80 complex is involved in DNA repair by associating with 'Ser-129' phosphorylated H2A histones as a response to DNA damage (PubMed:15607974, PubMed:15607975)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VU00", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding;GO:0140658 ATP-dependent chromatin remodeler activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031011 Ino80 complex;GO:0000775 chromosome, centromeric region;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P53115-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53118-1", "uniprot_id": [ { "id": "ROG1_YEAST", "url": "https://www.uniprot.org/uniprot/P53118", "type": "external" } ], "mass": 78142.0, "length": 685, "protein_name": "Putative lipase ROG1", "gene_name": "ROG1", "organism": "Yeast", "refseq_name": "putative lipase ROG1", "refseq_ac": [ { "id": "NP_011371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011371", "type": "external" } ], "gene_names_uniprotkb": "ROG1", "gene_names_refseq": "ROG1", "protein_names_uniprotkb": "Putative lipase ROG1; 3.1.-.-; Revertant of glycogen synthase kinase mutation protein 1", "protein_names_refseq": "putative lipase ROG1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL144C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17322287;24374639;33491328;9046099;9169869", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU05;Q66RA3", "ec_number_list": [], "go_molecular_function": "GO:0047372 monoacylglycerol lipase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P53118-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53119-1", "uniprot_id": [ { "id": "HUL5_YEAST", "url": "https://www.uniprot.org/uniprot/P53119", "type": "external" } ], "mass": 105566.0, "length": 910, "protein_name": "E3 ubiquitin-protein ligase HUL5", "gene_name": "HUL5", "organism": "Yeast", "refseq_name": "ubiquitin-ubiquitin ligase HUL5", "refseq_ac": [ { "id": "NP_011374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011374", "type": "external" } ], "gene_names_uniprotkb": "HUL5", "gene_names_refseq": "HUL5", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HUL5; 2.3.2.26", "protein_names_refseq": "ubiquitin-ubiquitin ligase HUL5", "tax_id": 559292, "disease": "Kaufman oculocerebrofacial syndrome (Disease Ontology:DOID:0111456)", "pathway": " (sce:YGL141W); (R-SCE-983168)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "14562095;14562106;17190603;17322287;19795423;19823750;20008553;21983566;22814378;24374639;33491328;9046099;9169869;9858558", "class_list": "", "function": "Non-essential E3 ubiquitin-protein ligase that specifically catalyzes 'Lys-29'- and 'Lys-48'-linked polyubiquitin chains (By similarity). Accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Associates with the proteasome and promotes elongation of ubiquitin chains on substrates bound to the proteasome (PubMed:17190603). Elongation of ubiquitin chains on substrates bound to the proteasome promotes proteasomal processivity (PubMed:20008553). Also promotes ubiquitin elongation of 26S proteasome subunit RPN10 (PubMed:17190603). Involved in the stress response required to maintain cell fitness following heat-shock: acts by mediating ubiquitination of cytosolic misfolded proteins, leading to their subsequent degradation (PubMed:21983566)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU08", "ec_number_list": [ { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "1.14.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0034450 ubiquitin-ubiquitin ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex", "go_biological_process": "GO:0034605 cellular response to heat;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0033554 cellular response to stress", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P53119-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53127-1", "uniprot_id": [ { "id": "SNT2_YEAST", "url": "https://www.uniprot.org/uniprot/P53127", "type": "external" } ], "mass": 163203.0, "length": 1403, "protein_name": "E3 ubiquitin-protein ligase SNT2", "gene_name": "SNT2", "organism": "Yeast", "refseq_name": "DNA-binding E3 ubiquitin-protein ligase SNT2", "refseq_ac": [ { "id": "NP_011384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011384", "type": "external" } ], "gene_names_uniprotkb": "SNT2; G2850", "gene_names_refseq": "SNT2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase SNT2; 2.3.2.27; Histone E3 ligase SNT2; RING-type E3 ubiquitin transferase SNT2; SANT domain-containing protein 2", "protein_names_refseq": "DNA-binding E3 ubiquitin-protein ligase SNT2", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL131C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562095;17142463;19040720;19779198;21177495;22570702;23749301;23878396;24374639;32597660;33481703;33491328;8840506;9169869", "class_list": "", "function": "Transcriptional regulator that, together with ECM5, recruits histone deacetylase RPD3 to a small number of promoters of stress-response genes in response to oxidative stress (PubMed:23878396). Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation (PubMed:22570702)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU17", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048189 Lid2 complex;GO:0070211 Snt2C complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006979 response to oxidative stress;GO:0006355 regulation of DNA-templated transcription;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P53127-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53129-1", "uniprot_id": [ { "id": "MON1_YEAST", "url": "https://www.uniprot.org/uniprot/P53129", "type": "external" } ], "mass": 73478.0, "length": 644, "protein_name": "Vacuolar fusion protein MON1", "gene_name": "MON1", "organism": "Yeast", "refseq_name": "guanine nucleotide exchange factor MON1", "refseq_ac": [ { "id": "NP_011391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011391", "type": "external" } ], "gene_names_uniprotkb": "MON1; AUT12; G2889", "gene_names_refseq": "AUT12; MON1", "protein_names_uniprotkb": "Vacuolar fusion protein MON1; Autophagy-related protein 12; Monensin sensitivity protein 1", "protein_names_refseq": "guanine nucleotide exchange factor MON1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL124C); (R-SCE-8876198)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "12134085;12364329;12387888;14562095;14662743;15721293;17563356;18407956;19779198;20797862;23749301;24374639;32391792;32597660;33481703;33491328;37463208;8896269;9169869", "class_list": "", "function": "In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking (PubMed:12134085, PubMed:12364329, PubMed:12387888, PubMed:14662743, PubMed:15721293, PubMed:32391792, PubMed:37463208). The MON1-CCZ1 complex is recruited to membranes enriched in charged lipids, particularly phosphatidylinositol 3-phosphate (PtdIns[3]P), by GTP-associated small GTPase RAB5 homologs (YPT10, YPT52, YPT53 and VPS21) (PubMed:32391792). The MON1-CCZ1 complex recruits GDP-associated small GTPase YPT7 to membranes and acts as a guanine nucleotide-exchange factor (GEF), promoting nucleotide-exchange on YPT7 and triggering endosomal maturation by recruiting downstream effectors such as components of the HOPS tethering complex (PubMed:20797862, PubMed:32391792)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU24", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0001786 phosphatidylserine binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:1990624 guanyl nucleotide exchange factor inhibitor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0032585 multivesicular body membrane;GO:0000329 fungal-type vacuole membrane;GO:0035658 Mon1-Ccz1 complex", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0016236 macroautophagy;GO:0006914 autophagy;GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway;GO:0048278 vesicle docking", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P53129-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53140-1", "uniprot_id": [ { "id": "RMD9_YEAST", "url": "https://www.uniprot.org/uniprot/P53140", "type": "external" } ], "mass": 74596.0, "length": 646, "protein_name": "RNA-binding protein RMD9, mitochondrial", "gene_name": "RMD9", "organism": "Yeast", "refseq_name": "Rmd9p", "refseq_ac": [ { "id": "NP_011408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011408", "type": "external" } ], "gene_names_uniprotkb": "RMD9; G3075", "gene_names_refseq": "RMD9", "protein_names_uniprotkb": "RNA-binding protein RMD9, mitochondrial; DBP; Dodecamer binding protein; Required for meiotic nuclear division protein 9", "protein_names_refseq": "Rmd9p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL107C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10441495;10905425;12586695;14562095;14562106;14576278;17194786;17194787;17322287;24374639;33876744;9046090;9169869", "class_list": "", "function": "Binds the RNA motif 5'-AAUAA[U/C]AUUCUU-3' in the 3'-UTR of mitochondrial mRNAs (PubMed:10441495, PubMed:10905425, PubMed:33876744). Involved in the processing or stability of mitochondrial mRNAs (PubMed:17194786, PubMed:17194787, PubMed:33876744)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU39;Q66RA9", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0043488 regulation of mRNA stability;GO:0006413 translational initiation;GO:0070935 3'-UTR-mediated mRNA stabilization;GO:0009060 aerobic respiration;GO:1903108 regulation of mitochondrial transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P53140-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53145-1", "uniprot_id": [ { "id": "LSG1_YEAST", "url": "https://www.uniprot.org/uniprot/P53145", "type": "external" } ], "mass": 72728.0, "length": 640, "protein_name": "Large subunit GTPase 1", "gene_name": "LSG1", "organism": "Yeast", "refseq_name": "ribosome biogenesis GTPase LSG1", "refseq_ac": [ { "id": "NP_011416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011416", "type": "external" } ], "gene_names_uniprotkb": "LSG1", "gene_names_refseq": "KRE35; LSG1", "protein_names_uniprotkb": "Large subunit GTPase 1; 3.6.1.-", "protein_names_refseq": "ribosome biogenesis GTPase LSG1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL099W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12773575;14562095;14562106;15660131;15831484;16260602;17015443;17761675;19779198;21177495;23749301;24374639;33481703;33491328;34965436;9169869;9290212", "class_list": "", "function": "GTPase required for the nuclear export of the 60S ribosomal subunit. Acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VU46", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit;GO:0043332 mating projection tip", "go_biological_process": "GO:0015031 protein transport;GO:0000054 ribosomal subunit export from nucleus;GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P53145-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53148-1", "uniprot_id": [ { "id": "KNL1_YEAST", "url": "https://www.uniprot.org/uniprot/P53148", "type": "external" } ], "mass": 104826.0, "length": 917, "protein_name": "Outer kinetochore KNL1 complex subunit SPC105", "gene_name": "SPC105", "organism": "Yeast", "refseq_name": "kinetochore-microtubule binding complex subunit SPC105", "refseq_ac": [ { "id": "NP_011422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011422", "type": "external" } ], "gene_names_uniprotkb": "SPC105; KNL1", "gene_names_refseq": "SPC105", "protein_names_uniprotkb": "Outer kinetochore KNL1 complex subunit SPC105; 105 kDa spindle pole component protein; Spindle pole body component SPC105", "protein_names_refseq": "kinetochore-microtubule binding complex subunit SPC105", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL093W)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "14562095;14565975;16715078;17330950;18407956;19779198;19795423;19823750;19893618;20489023;20702584;21126336;22521787;22561345;23749301;24066227;24374639;32597660;32997987;33481703;33491328;35042402;9169869;9290212;9585415", "class_list": "", "function": "Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:19893618, PubMed:22521787, PubMed:32997987, PubMed:35042402). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:19893618). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:19893618, PubMed:22521787, PubMed:32997987, PubMed:35042402). Recruits the BUB1-BUB3 complex to kinetochores when phosphorylated by MPS1, to support spindle assembly checkpoint signaling; the effect is reversed by protein phosphatase 1 (PP1) (PubMed:22521787). The KNL1 complex is required for kinetochore binding by the kMAPs (kinetochore-bound microtubule-associated proteins) BIM1, BIK1 and SLK19, and motors CIN8 and KAR3 (PubMed:19893618)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU52", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0000776 kinetochore;GO:0000940 outer kinetochore;GO:0180019 Knl1/Spc105 complex", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0031619 homologous chromosome orientation in meiotic metaphase I;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0034501 protein localization to kinetochore;GO:0031134 sister chromatid biorientation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P53148-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53152-1", "uniprot_id": [ { "id": "MMS2_YEAST", "url": "https://www.uniprot.org/uniprot/P53152", "type": "external" } ], "mass": 15545.0, "length": 137, "protein_name": "Ubiquitin-conjugating enzyme variant MMS2", "gene_name": "MMS2", "organism": "Yeast", "refseq_name": "E2 ubiquitin-conjugating protein MMS2", "refseq_ac": [ { "id": "NP_011428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011428", "type": "external" } ], "gene_names_uniprotkb": "MMS2", "gene_names_refseq": "MMS2", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme variant MMS2; UEV MMS2", "protein_names_refseq": "E2 ubiquitin-conjugating protein MMS2", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL087C); (R-SCE-9646399); (R-SCE-983168)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10089880;10880451;11440714;14562106;18407956;24374639;25690888;33481703;33491328;9169869;9290212;9576943;9705497", "class_list": "", "function": "Promotes the template-switching (TS) branch of the DNA damage tolerance (DDT) pathway (also known as the post-replication repair (PRR) pathway), that bypasses replication-blocking lesions without removing them (PubMed:10880451). Together with ubiquitin-protein ligase RAD5 and ubiquitin-conjugating enzyme UBC13, synthesizes 'Lys-63'-linked polyubiquitin chains on monoubiquitinated POL30/PCNA, to promote template-switching to the newly synthesized sister chromatid for error-free synthesis past the DNA lesion (PubMed:10880451, PubMed:25690888)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU57", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031371 ubiquitin conjugating enzyme complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0070534 protein K63-linked ubiquitination;GO:0010994 free ubiquitin chain polymerization;GO:0006301 DNA damage tolerance;GO:0044395 protein targeting to vacuolar membrane", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P53152-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53153-1", "uniprot_id": [ { "id": "LCL3_YEAST", "url": "https://www.uniprot.org/uniprot/P53153", "type": "external" } ], "mass": 32112.0, "length": 274, "protein_name": "Probable endonuclease LCL3", "gene_name": "LCL3", "organism": "Yeast", "refseq_name": "Lcl3p", "refseq_ac": [ { "id": "NP_011430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011430", "type": "external" } ], "gene_names_uniprotkb": "LCL3", "gene_names_refseq": "LCL3", "protein_names_uniprotkb": "Probable endonuclease LCL3; 3.1.-.-; Long chronological lifespan protein 3", "protein_names_refseq": "Lcl3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL085W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;17351896;20421943;21126336;24374639;9169869;9290212", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU59", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P53153-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53154-1", "uniprot_id": [ { "id": "GUP1_YEAST", "url": "https://www.uniprot.org/uniprot/P53154", "type": "external" } ], "mass": 65340.0, "length": 560, "protein_name": "Membrane-bound O-acyltransferase GUP1", "gene_name": "GUP1", "organism": "Yeast", "refseq_name": "O-acyltransferase", "refseq_ac": [ { "id": "NP_011431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011431", "type": "external" } ], "gene_names_uniprotkb": "GUP1", "gene_names_refseq": "GUP1", "protein_names_uniprotkb": "Membrane-bound O-acyltransferase GUP1; Glycerol uptake protein 1", "protein_names_refseq": "O-acyltransferase", "tax_id": 559292, "disease": "chondrodysplasia-pseudohermaphroditism syndrome (Disease Ontology:DOID:0060644)", "pathway": " (sce:YGL084C)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10694878;10747858;10931309;14562095;14562106;15278288;15381122;15813700;16597698;16847258;17042752;18036137;18407956;18786505;21177495;21849510;22617017;22814378;24374639;25589358;30184078;32597660;33481703;34965436;9169869;9290212", "class_list": "", "function": "Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors. Acts only on GPI-anchored proteins, but not on free GPI lipids. Acts as an acyltransferase for GPI anchors that adds C26 fatty acids to the sn2 position of lyso-PI-containing GPI anchors. PER1 first deacylates, GUP1 subsequently reacylates the anchor lipid, thus replacing a shorter fatty acid (C16:0 or C18:0) by C26:0 (PubMed:16597698, PubMed:18036137). Also involved in lipid metabolism, having profound effects on sphingolipid-sterol-ordered domains integrity and assembly (PubMed:18786505). Together with GUP2, has an influence on the chemical composition of the yeast extracellular matrix (yECM) in yeast multicellular aggregates, such as biofilms and colonies (PubMed:25589358). Involved in cell integrity and apoptosis (PubMed:22617017, PubMed:30184078)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU60", "ec_number_list": [], "go_molecular_function": "GO:0008374 O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0015793 glycerol transmembrane transport;GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P53154-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53157-1", "uniprot_id": [ { "id": "MPC1_YEAST", "url": "https://www.uniprot.org/uniprot/P53157", "type": "external" } ], "mass": 14995.0, "length": 130, "protein_name": "Mitochondrial pyruvate carrier 1", "gene_name": "MPC1", "organism": "Yeast", "refseq_name": "pyruvate transporter MPC1", "refseq_ac": [ { "id": "NP_011435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011435", "type": "external" } ], "gene_names_uniprotkb": "MPC1; FMP37", "gene_names_refseq": "FMP37; MPC1", "protein_names_uniprotkb": "Mitochondrial pyruvate carrier 1; MPC1; Protein FMP37", "protein_names_refseq": "pyruvate transporter MPC1", "tax_id": 559292, "disease": "mitochondrial pyruvate carrier deficiency (Disease Ontology:DOID:0080363); intestinal cancer (Disease Ontology:DOID:10155); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (sce:YGL080W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;14562106;14576278;17322287;22628554;22628558;24374639;25672363;30979775;9169869;9290212", "class_list": "", "function": "As part of a pyruvate import complex, mediates the uptake of pyruvate into mitochondria (PubMed:22628554, PubMed:22628558, PubMed:25672363, PubMed:30979775). In fermentative conditions it functions together with MPC2 and in respiratory conditions with MPC3; the MPC1-MPC3 carrier has higher pyruvate transport activity than MPC1-MPC2 and can therefore more efficiently support ATP production by oxidative phosphorylation (PubMed:25672363)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU64", "ec_number_list": [], "go_molecular_function": "GO:0050833 pyruvate transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005777 peroxisome;GO:7770001 mitochondrial pyruvate carrier complex", "go_biological_process": "GO:0006850 pyruvate import into mitochondria", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53157-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53159-1", "uniprot_id": [ { "id": "MPS2_YEAST", "url": "https://www.uniprot.org/uniprot/P53159", "type": "external" } ], "mass": 44585.0, "length": 387, "protein_name": "Monopolar spindle protein 2", "gene_name": "MPS2", "organism": "Yeast", "refseq_name": "Mps2p", "refseq_ac": [ { "id": "NP_011440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011440", "type": "external" } ], "gene_names_uniprotkb": "MPS2; MMC1", "gene_names_refseq": "MMC1; MPS2", "protein_names_uniprotkb": "Monopolar spindle protein 2", "protein_names_refseq": "Mps2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL075C)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10397772;10654940;11952896;12399372;16436507;16923827;18407956;1869587;19795423;19823750;20702584;21126336;23749301;24374639;32597660;33481703;33491328;9060463;9169869;9290212", "class_list": "", "function": "Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU69", "ec_number_list": [], "go_molecular_function": "GO:0140444 cytoskeleton-nuclear membrane anchor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005640 nuclear outer membrane;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0030474 spindle pole body duplication;GO:0000741 karyogamy;GO:0071988 protein localization to spindle pole body;GO:1990608 mitotic spindle pole body localization;GO:0044821 meiotic telomere tethering at nuclear periphery", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P53159-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53163-1", "uniprot_id": [ { "id": "MNP1_YEAST", "url": "https://www.uniprot.org/uniprot/P53163", "type": "external" } ], "mass": 20650.0, "length": 194, "protein_name": "Large ribosomal subunit protein bL12m", "gene_name": "MNP1", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein bL12m MNP1", "refseq_ac": [ { "id": "NP_011447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011447", "type": "external" } ], "gene_names_uniprotkb": "MNP1; MRPL12", "gene_names_refseq": "MNP1; bL12m", "protein_names_uniprotkb": "Large ribosomal subunit protein bL12m; 54S ribosomal protein L12, mitochondrial; Mitochondrial-nucleoid protein 1", "protein_names_refseq": "mitochondrial 54S ribosomal protein bL12m MNP1", "tax_id": 559292, "disease": "combined oxidative phosphorylation deficiency 45 (Disease Ontology:DOID:0112113)", "pathway": " (sce:YGL068W); (R-SCE-9837999)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14562095;14562106;14576278;15221522;16451194;19756047;24374639;24675956;25609543;9169869;9290212", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VU73", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53163-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53164-1", "uniprot_id": [ { "id": "NPY1_YEAST", "url": "https://www.uniprot.org/uniprot/P53164", "type": "external" } ], "mass": 43516.0, "length": 384, "protein_name": "NAD-capped RNA hydrolase NPY1", "gene_name": "NPY1", "organism": "Yeast", "refseq_name": "NAD(+) diphosphatase", "refseq_ac": [ { "id": "NP_011448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011448", "type": "external" } ], "gene_names_uniprotkb": "NPY1", "gene_names_refseq": "NPY1", "protein_names_uniprotkb": "NAD-capped RNA hydrolase NPY1; 3.6.1.-; 3.6.1.22; DeNADding enzyme NPY1; NADH pyrophosphatase", "protein_names_refseq": "NAD(+) diphosphatase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL067W); (R-SCE-196807)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10873676;11361135;14562106;17322287;24374639;9169869", "class_list": "", "function": "mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Mediates the hydrolysis of some nucleoside diphosphate derivatives (PubMed:11361135)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU74;E9P928", "ec_number_list": [ { "id": "3.6.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.22", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0000210 NAD+ diphosphatase activity;GO:0046872 metal ion binding;GO:0035529 NADH pyrophosphatase activity;GO:0110153 RNA NAD-cap (NMN-forming) hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0019677 NAD+ catabolic process;GO:0019674 NAD+ metabolic process;GO:0006742 NADP+ catabolic process;GO:0110155 NAD-cap decapping;GO:0110154 RNA decapping", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P53164-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53165-1", "uniprot_id": [ { "id": "SGF73_YEAST", "url": "https://www.uniprot.org/uniprot/P53165", "type": "external" } ], "mass": 72878.0, "length": 657, "protein_name": "SAGA complex subunit SGF73", "gene_name": "SGF73", "organism": "Yeast", "refseq_name": "deubiquitination module subunit SGF73", "refseq_ac": [ { "id": "NP_011449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011449", "type": "external" } ], "gene_names_uniprotkb": "SGF73", "gene_names_refseq": "SCA7; SGF73", "protein_names_uniprotkb": "SAGA complex subunit SGF73; 73 kDa SAGA-associated factor; SAGA histone acetyltransferase complex 73 kDa subunit; SAGA-associated factor 73", "protein_names_refseq": "deubiquitination module subunit SGF73", "tax_id": 559292, "disease": "spinocerebellar ataxia 7 (Disease Ontology:DOID:0050958)", "pathway": " (sce:YGL066W)", "pathway_count": 1, "publication_count": 33, "publication_id_list": "12052880;14562106;15260971;15932941;17090597;17563356;18407956;18488019;19226466;19779198;20190278;20395473;20434206;20489023;20702584;22771212;22932476;23749301;24374639;25216679;25526805;26912860;28918903;30516470;31165730;31969703;32597660;33481703;33491328;33864814;9169869;9234674;9290212", "class_list": "", "function": "Component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription (PubMed:25216679). At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module) (PubMed:17090597, PubMed:31969703). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B (PubMed:20395473). SAGA interacts with DNA via upstream activating sequences (UASs) (PubMed:25216679). Also identified in a modified version of SAGA named SALSA or SLIK (PubMed:15932941). The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities (PubMed:33864814). SGF73 tethers the DUB module to the rest of the SAGA complex through its central domain and activates the ubiquitin hydrolase UBP8 by maintaining its catalytic domain in an active conformation (PubMed:18488019, PubMed:19226466, PubMed:20395473, PubMed:25526805). SGF73 mediates recruitment of the TREX-2 mRNA export factors SAC3 and THP1 to SAGA, which is crucial to target TREX-2 to the nuclear pore complex (NPC) necessary for export of mRNA (PubMed:18488019). Upon environmental stress, involved in the bypass of the canonical mRNA export process for the immediate export of stress-related transcripts to maintain proteostasis (PubMed:31165730)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU75", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0071819 DUBm complex;GO:0000124 SAGA complex;GO:0046695 SLIK (SAGA-like) complex", "go_biological_process": "GO:1905634 regulation of protein localization to chromatin;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006406 mRNA export from nucleus;GO:0046822 regulation of nucleocytoplasmic transport", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P53165-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53166-1", "uniprot_id": [ { "id": "MRH4_YEAST", "url": "https://www.uniprot.org/uniprot/P53166", "type": "external" } ], "mass": 63058.0, "length": 561, "protein_name": "ATP-dependent RNA helicase MRH4, mitochondrial", "gene_name": "MRH4", "organism": "Yeast", "refseq_name": "ATP-dependent RNA helicase", "refseq_ac": [ { "id": "NP_011451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011451", "type": "external" } ], "gene_names_uniprotkb": "MRH4", "gene_names_refseq": "MRH4", "protein_names_uniprotkb": "ATP-dependent RNA helicase MRH4, mitochondrial; 3.6.4.13; Mitochondrial RNA helicase 4", "protein_names_refseq": "ATP-dependent RNA helicase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL064C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10077188;12702275;14562095;14562106;14576278;19795423;19823750;24374639;33491328;9169869;9234674", "class_list": "", "function": "ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU77", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:1990400 mitochondrial ribosomal large subunit rRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016070 RNA metabolic process;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:1902775 mitochondrial large ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53166-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53169-1", "uniprot_id": [ { "id": "YBP2_YEAST", "url": "https://www.uniprot.org/uniprot/P53169", "type": "external" } ], "mass": 73102.0, "length": 641, "protein_name": "YAP1-binding protein 2", "gene_name": "YBP2", "organism": "Yeast", "refseq_name": "Ybp2p", "refseq_ac": [ { "id": "NP_011455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011455", "type": "external" } ], "gene_names_uniprotkb": "YBP2; YBH1", "gene_names_refseq": "YBH1; YBP2", "protein_names_uniprotkb": "YAP1-binding protein 2; YBP1 homolog protein 1", "protein_names_refseq": "Ybp2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL060W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11570514;12743123;14562095;14562106;15075262;24374639;9169869;9234674;9990050", "class_list": "", "function": "Involved in oxidative stress response and redox homeostasis. Required for hydrogen peroxide-induced activation of YAP1. Acts in a parallele pathway to YBP1., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU81", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000776 kinetochore", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P53169-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53170-1", "uniprot_id": [ { "id": "PDK2_YEAST", "url": "https://www.uniprot.org/uniprot/P53170", "type": "external" } ], "mass": 57294.0, "length": 491, "protein_name": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial", "gene_name": "PKP2", "organism": "Yeast", "refseq_name": "protein kinase PKP2", "refseq_ac": [ { "id": "NP_011456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011456", "type": "external" } ], "gene_names_uniprotkb": "PKP2", "gene_names_refseq": "PKP2", "protein_names_uniprotkb": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial; 2.7.11.2; PDC kinase 2; PDK 2; Protein kinase of PDH protein 2; Pyruvate dehydrogenase complex kinase 2; Pyruvate dehydrogenase kinase 2; [Pyruvate dehydrogenase [lipoamide]] kinase 2", "protein_names_refseq": "protein kinase PKP2", "tax_id": 559292, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); branched-chain keto acid dehydrogenase kinase deficiency (Disease Ontology:DOID:0090126); oligospermia (Disease Ontology:DOID:14228)", "pathway": " (sce:YGL059W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11152879;14562095;14562106;16319894;16823961;17918780;18180296;19795423;19823750;24374639;33491328;9169869;9234674", "class_list": "", "function": "Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit (PDA1), thus contributing to the regulation of glucose metabolism., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU82", "ec_number_list": [ { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" } ], "go_molecular_function": "GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0010906 regulation of glucose metabolic process;GO:0010510 regulation of pyruvate decarboxylation to acetyl-CoA;GO:1901524 regulation of mitophagy", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P53170-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53173-1", "uniprot_id": [ { "id": "ERV14_YEAST", "url": "https://www.uniprot.org/uniprot/P53173", "type": "external" } ], "mass": 15930.0, "length": 138, "protein_name": "ER-derived vesicles protein ERV14", "gene_name": "ERV14", "organism": "Yeast", "refseq_name": "cornichon family protein", "refseq_ac": [ { "id": "NP_011461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011461", "type": "external" } ], "gene_names_uniprotkb": "ERV14", "gene_names_refseq": "ERV14", "protein_names_uniprotkb": "ER-derived vesicles protein ERV14", "protein_names_refseq": "cornichon family protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL054C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;17322287;24374639;9169869;9234674;9732282", "class_list": "", "function": "Could regulate export of the bud site and axial growth sites selection protein AXL2 and possibly other secretory proteins from the endoplasmic reticulum in COPII-coated vesicles. Seems to be required for axial budding pattern in haploid cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU87", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:2000311 regulation of AMPA receptor activity;GO:1902684 negative regulation of receptor localization to synapse;GO:0007120 axial cellular bud site selection;GO:0030437 ascospore formation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P53173-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53176-1", "uniprot_id": [ { "id": "MST27_YEAST", "url": "https://www.uniprot.org/uniprot/P53176", "type": "external" } ], "mass": 27241.0, "length": 234, "protein_name": "Multicopy suppressor of SEC21 protein 27", "gene_name": "MST27", "organism": "Yeast", "refseq_name": "DUP240 family protein MST27", "refseq_ac": [ { "id": "NP_011464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011464", "type": "external" } ], "gene_names_uniprotkb": "MST27; DUP2", "gene_names_refseq": "MST27", "protein_names_uniprotkb": "Multicopy suppressor of SEC21 protein 27; DUP240 protein MST27; Protein DUP2", "protein_names_refseq": "DUP240 family protein MST27", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL051W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12101299;12925749;16847258;24374639;32597660;9169869;9234674", "class_list": "", "function": "Involved in protein trafficking vesicle formation, probably by stabilizing of coatomer at the Golgi membrane and thus allowing the efficient formation of COPI coated vesicles., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU89", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0012507 ER to Golgi transport vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0016050 vesicle organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P53176-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53178-1", "uniprot_id": [ { "id": "ALG13_YEAST", "url": "https://www.uniprot.org/uniprot/P53178", "type": "external" } ], "mass": 22661.0, "length": 202, "protein_name": "UDP-N-acetylglucosamine transferase subunit ALG13", "gene_name": "ALG13", "organism": "Yeast", "refseq_name": "N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit ALG13", "refseq_ac": [ { "id": "NP_011468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011468", "type": "external" } ], "gene_names_uniprotkb": "ALG13", "gene_names_refseq": "ALG13", "protein_names_uniprotkb": "UDP-N-acetylglucosamine transferase subunit ALG13; 2.4.1.141; Asparagine-linked glycosylation protein 13", "protein_names_refseq": "N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit ALG13", "tax_id": 559292, "disease": "developmental and epileptic encephalopathy 36 (Disease Ontology:DOID:0080470)", "pathway": " (sce:YGL047W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;15615718;16100110;24374639;33491328;9169869;9234674", "class_list": "glycogene;glycosyltransferase", "function": "Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU93", "ec_number_list": [ { "id": "2.4.1.141", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.141", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004577 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0043541 UDP-N-acetylglucosamine transferase complex", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P53178-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53184-1", "uniprot_id": [ { "id": "PNC1_YEAST", "url": "https://www.uniprot.org/uniprot/P53184", "type": "external" } ], "mass": 24993.0, "length": 216, "protein_name": "Nicotinamidase", "gene_name": "PNC1", "organism": "Yeast", "refseq_name": "nicotinamidase", "refseq_ac": [ { "id": "NP_011478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011478", "type": "external" } ], "gene_names_uniprotkb": "PNC1", "gene_names_refseq": "PNC1", "protein_names_uniprotkb": "Nicotinamidase; 3.5.1.19; NAMase; Nicotinamide deamidase", "protein_names_refseq": "nicotinamidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL037C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11816029;12736687;14562095;14562106;14729974;17322287;17382284;18407956;24374639;33491328;4326215;6058082;9169869", "class_list": "", "function": "Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway. Positively regulates SIR2-mediated silencing and longevity by preventing the accumulation of intracellular nicotinamide, an inhibitor of SIR2, during times of stress. Also acts on nicotinyl hydroxamate., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUA2", "ec_number_list": [ { "id": "3.5.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.19", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008936 nicotinamidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0000183 rDNA heterochromatin formation;GO:0019358 nicotinate nucleotide salvage;GO:1904524 negative regulation of DNA amplification", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P53184-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53191-1", "uniprot_id": [ { "id": "PIB2_YEAST", "url": "https://www.uniprot.org/uniprot/P53191", "type": "external" } ], "mass": 70617.0, "length": 635, "protein_name": "Glutamine sensor PIB2", "gene_name": "PIB2", "organism": "Yeast", "refseq_name": "Pib2p", "refseq_ac": [ { "id": "NP_011492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011492", "type": "external" } ], "gene_names_uniprotkb": "PIB2", "gene_names_refseq": "PIB2", "protein_names_uniprotkb": "Glutamine sensor PIB2; Phosphatidylinositol 3-phosphate-binding protein 2", "protein_names_refseq": "Pib2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL023C)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "14562095;17287358;17322287;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;23749301;24374639;26510498;28483912;28993463;29698392;30516470;31622882;32597660;32801125;33229814;33481703;33491328;34535752;34965436;9169869", "class_list": "", "function": "Functions as an intracellular glutamine sensor that directly activates the TORC1 signaling pathway, to promote cell growth when glutamine is available (PubMed:26510498, PubMed:28483912, PubMed:29698392, PubMed:32801125, PubMed:34535752). May play a role in repressing NPR1 activity independently of TORC1 signaling (PubMed:28993463)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 14, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 14, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 14, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 61, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "D6VUB4;E9P8Z2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0140785 amino acid sensor activity;GO:1902485 L-cysteine binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "P53191-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53192-1", "uniprot_id": [ { "id": "GET1_YEAST", "url": "https://www.uniprot.org/uniprot/P53192", "type": "external" } ], "mass": 27092.0, "length": 235, "protein_name": "Golgi to ER traffic protein 1", "gene_name": "GET1", "organism": "Yeast", "refseq_name": "GET complex subunit GET1", "refseq_ac": [ { "id": "NP_011495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011495", "type": "external" } ], "gene_names_uniprotkb": "GET1; MDM39", "gene_names_refseq": "GET1; MDM39", "protein_names_uniprotkb": "Golgi to ER traffic protein 1; Guided entry of tail-anchored proteins 1; Mitochondrial distribution and morphology protein 39", "protein_names_refseq": "GET complex subunit GET1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL020C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11805837;11907266;14562095;14562106;15909163;16269340;16816426;16823961;18724936;21719644;21835666;24374639;24392163;32910895;9169869", "class_list": "", "function": "Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in mitochondrial distribution and morphology., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUB7", "ec_number_list": [], "go_molecular_function": "GO:0043495 protein-membrane adaptor activity;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045048 protein insertion into ER membrane;GO:0097051 establishment of protein localization to endoplasmic reticulum membrane;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0000423 mitophagy;GO:0071816 tail-anchored membrane protein insertion into ER membrane", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P53192-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53193-1", "uniprot_id": [ { "id": "JAC1_YEAST", "url": "https://www.uniprot.org/uniprot/P53193", "type": "external" } ], "mass": 21778.0, "length": 184, "protein_name": "J-type co-chaperone JAC1, mitochondrial", "gene_name": "JAC1", "organism": "Yeast", "refseq_name": "J-type chaperone JAC1", "refseq_ac": [ { "id": "NP_011497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011497", "type": "external" } ], "gene_names_uniprotkb": "JAC1; SEO2", "gene_names_refseq": "JAC1", "protein_names_uniprotkb": "J-type co-chaperone JAC1, mitochondrial; J-type accessory chaperone 1", "protein_names_refseq": "J-type chaperone JAC1", "tax_id": 559292, "disease": "sideroblastic anemia 5 (Disease Ontology:DOID:0061007)", "pathway": " (sce:YGL018C); (R-SCE-1268020); (R-SCE-1362409); (R-SCE-9865881)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "11171977;11273703;11278728;12756240;12970193;14562095;14562106;14576278;15123690;16431909;16551614;17322287;23615440;24374639;26545917;9169869;9813017", "class_list": "", "function": "Co-chaperone required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Stimulates the ATPase activity of its specialized Hsp70 chaperone partner SSQ1, to mediate the transfer of iron-sulfur clusters from ISU1 to GRX5. Binds to the substrate protein ISU1 and targets it to SSQ1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUB9", "ec_number_list": [], "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0051259 protein complex oligomerization;GO:0006879 intracellular iron ion homeostasis;GO:0009060 aerobic respiration;GO:0044571 [2Fe-2S] cluster assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P53193-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53195-1", "uniprot_id": [ { "id": "COG7_YEAST", "url": "https://www.uniprot.org/uniprot/P53195", "type": "external" } ], "mass": 31775.0, "length": 279, "protein_name": "Conserved oligomeric Golgi complex subunit 7", "gene_name": "COG7", "organism": "Yeast", "refseq_name": "Golgi transport complex subunit COG7", "refseq_ac": [ { "id": "NP_011510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011510", "type": "external" } ], "gene_names_uniprotkb": "COG7; COD5", "gene_names_refseq": "COD5; COG7", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 7; COG complex subunit 7; Complexed with DOR1 protein 5; Component of oligomeric Golgi complex 7", "protein_names_refseq": "Golgi transport complex subunit COG7", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL005C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11703943;14562106;15047703;17322287;18407956;24374639;9169869", "class_list": "", "function": "Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUD3;E9P921", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0000301 retrograde transport, vesicle recycling within Golgi;GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P53195-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53197-1", "uniprot_id": [ { "id": "CDH1_YEAST", "url": "https://www.uniprot.org/uniprot/P53197", "type": "external" } ], "mass": 62821.0, "length": 566, "protein_name": "APC/C activator protein CDH1", "gene_name": "CDH1", "organism": "Yeast", "refseq_name": "Cdh1p", "refseq_ac": [ { "id": "NP_011512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011512", "type": "external" } ], "gene_names_uniprotkb": "CDH1; HCT1", "gene_names_refseq": "CDH1; HCT1", "protein_names_uniprotkb": "APC/C activator protein CDH1; CDC20 homolog 1; Homolog of CDC twenty 1", "protein_names_refseq": "Cdh1p", "tax_id": 559292, "disease": "developmental and epileptic encephalopathy 109 (Disease Ontology:DOID:0070378); disease of cellular proliferation (Disease Ontology:DOID:14566)", "pathway": " (sce:YGL003C); (R-SCE-176407); (R-SCE-983168)", "pathway_count": 3, "publication_count": 25, "publication_id_list": "10074450;10329618;11448992;11562348;11566880;12456658;14574415;15467459;16688214;17322287;17349956;17563356;18407956;18500339;19520826;19779198;19853567;20089834;23749301;24374639;32597660;33481703;33491328;9169869;9831566", "class_list": "", "function": "Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). During telophase and in the subsequent G1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (D-box) and an additional degradation signal termed the KEN box including ASE1, CDC20, the B-type cyclins CLB2 and CLB3, the polo-like kinase CDC5 and HSL1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1. Probably is the target of a BUB2-dependent spindle checkpoint pathway., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 59, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUD5", "ec_number_list": [], "go_molecular_function": "GO:0010997 anaphase-promoting complex binding;GO:0030332 cyclin binding;GO:1990757 ubiquitin ligase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:1902426 deactivation of mitotic spindle assembly checkpoint;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0045732 positive regulation of protein catabolic process;GO:0045842 positive regulation of mitotic metaphase/anaphase transition;GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P53197-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53201-1", "uniprot_id": [ { "id": "SWC4_YEAST", "url": "https://www.uniprot.org/uniprot/P53201", "type": "external" } ], "mass": 55213.0, "length": 476, "protein_name": "SWR1-complex protein 4", "gene_name": "SWC4", "organism": "Yeast", "refseq_name": "Swc4p", "refseq_ac": [ { "id": "NP_011516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011516", "type": "external" } ], "gene_names_uniprotkb": "SWC4; EAF2; GOD1", "gene_names_refseq": "EAF2; GOD1; SWC4", "protein_names_uniprotkb": "SWR1-complex protein 4; ESA1-associated factor 2", "protein_names_refseq": "Swc4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR002C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562095;14562106;14645854;14690591;14690608;15045029;15302830;15353583;15485911;17322287;22814378;23749301;24374639;32597660;33481703;33491328;9169869", "class_list": "", "function": "Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUD9", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000785 chromatin;GO:0000812 Swr1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P53201-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53202-1", "uniprot_id": [ { "id": "CUL3_YEAST", "url": "https://www.uniprot.org/uniprot/P53202", "type": "external" } ], "mass": 86115.0, "length": 744, "protein_name": "Cullin-3", "gene_name": "CUL3", "organism": "Yeast", "refseq_name": "cullin CUL3", "refseq_ac": [ { "id": "NP_011517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011517", "type": "external" } ], "gene_names_uniprotkb": "CUL3", "gene_names_refseq": "CUL3", "protein_names_uniprotkb": "Cullin-3; Cullin-B", "protein_names_refseq": "cullin CUL3", "tax_id": 559292, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); syndromic X-linked intellectual disability Cabezas type (Disease Ontology:DOID:0060822); neurodevelopmental disorder with or without autism or seizures (Disease Ontology:DOID:0061147); intellectual disability (Disease Ontology:DOID:1059); pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (sce:YGR003W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12676951;14562106;17296727;19920177;24374639;33491328;9169869", "class_list": "", "function": "As part of the CRL3 E3 ubiquitin ligase complex; polyubiquitylates monoubiquitylated RNA polymerase II subunit RPO21 to trigger its proteolysis; plays a role in global genomic repair., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUE0", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0160072 ubiquitin ligase complex scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0009411 response to UV;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0034644 cellular response to UV", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P53202-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53204-1", "uniprot_id": [ { "id": "NMA2_YEAST", "url": "https://www.uniprot.org/uniprot/P53204", "type": "external" } ], "mass": 44909.0, "length": 395, "protein_name": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2", "gene_name": "NMA2", "organism": "Yeast", "refseq_name": "nicotinamide-nucleotide adenylyltransferase NMA2", "refseq_ac": [ { "id": "NP_011524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011524", "type": "external" } ], "gene_names_uniprotkb": "NMA2", "gene_names_refseq": "NMA2", "protein_names_uniprotkb": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; 2.7.7.18; 2.7.7.1; NAD(+) diphosphorylase 2; NAD(+) pyrophosphorylase 2; NMN adenylyltransferase 2; NMN/NaMN adenylyltransferase 2; NMNAT 2; NaMN adenylyltransferase 2; NaMNAT 2; Nicotinamide-nucleotide adenylyltransferase 2; Nicotinate-nucleotide adenylyltransferase 2", "protein_names_refseq": "nicotinamide-nucleotide adenylyltransferase NMA2", "tax_id": 559292, "disease": "Leber congenital amaurosis 9 (Disease Ontology:DOID:0110005); spondyloepiphyseal dysplasia, sensorineural hearing loss, intellectual developmental disorder, and Leber congenital amaurosis (Disease Ontology:DOID:0112290); sciatic neuropathy (Disease Ontology:DOID:11446); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); neurodegenerative disease (Disease Ontology:DOID:1289); glaucoma (Disease Ontology:DOID:1686); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (sce:YGR010W); (R-SCE-196807)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11884393;12597897;14562106;17330950;18407956;19779198;20702584;24374639;24759102;33481703;33491328;9169869", "class_list": "", "function": "Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:12597897). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate to form deamido-NAD(+) (NaAD). Key enzyme in both de novo and salvage pathways for NAD(+) biosynthesis (By similarity). Predominantly acts in the salvage pathways via NMN (PubMed:11884393)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUE7", "ec_number_list": [ { "id": "2.7.7.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.1", "type": "external" }, { "id": "2.7.7.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004515 nicotinate-nucleotide adenylyltransferase activity;GO:0000309 nicotinamide-nucleotide adenylyltransferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0009435 NAD+ biosynthetic process;GO:0034355 NAD+ biosynthetic process via the salvage pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P53204-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53207-1", "uniprot_id": [ { "id": "SNU71_YEAST", "url": "https://www.uniprot.org/uniprot/P53207", "type": "external" } ], "mass": 71383.0, "length": 620, "protein_name": "U1 small nuclear ribonucleoprotein component SNU71", "gene_name": "SNU71", "organism": "Yeast", "refseq_name": "Snu71p", "refseq_ac": [ { "id": "NP_011527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011527", "type": "external" } ], "gene_names_uniprotkb": "SNU71", "gene_names_refseq": "SNU71", "protein_names_uniprotkb": "U1 small nuclear ribonucleoprotein component SNU71", "protein_names_refseq": "Snu71p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR013W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10504710;11804584;11877437;14562095;14562106;17330950;18407956;23749301;24374639;33481703;33491328;9169869;9290212;9630245", "class_list": "", "function": "Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUE9", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P53207-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53208-1", "uniprot_id": [ { "id": "EAT1_YEAST", "url": "https://www.uniprot.org/uniprot/P53208", "type": "external" } ], "mass": 37937.0, "length": 328, "protein_name": "Ethanol acetyltransferase 1", "gene_name": "EAT1", "organism": "Yeast", "refseq_name": "putative hydrolase", "refseq_ac": [ { "id": "NP_011529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011529", "type": "external" } ], "gene_names_uniprotkb": "EAT1", "gene_names_refseq": "EAT1", "protein_names_uniprotkb": "Ethanol acetyltransferase 1; 2.3.1.268; 3.1.1.-; 3.1.2.1; AAT; Acetyl-CoA hydrolase; Acetyl-CoA thioesterase; Alcohol acetyltransferase; Ethyl acetate esterase", "protein_names_refseq": "putative hydrolase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR015C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14562095;24374639;28356220;9169869;9290212", "class_list": "", "function": "Alcohol acetyltransferase that catalyzes the synthesis of ethyl acetate from ethanol and acetyl-CoA (PubMed:28356220). Can also function as a thioesterase by hydrolyzing acetyl-CoA in the absence of ethanol, as well as esterase hydrolyzing ethyl acetate (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUF1", "ec_number_list": [ { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "2.3.1.268", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.268", "type": "external" } ], "go_molecular_function": "GO:0003986 acetyl-CoA hydrolase activity;GO:0052689 carboxylic ester hydrolase activity;GO:0016453 C-acetyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P53208-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53218-1", "uniprot_id": [ { "id": "POP6_YEAST", "url": "https://www.uniprot.org/uniprot/P53218", "type": "external" } ], "mass": 18210.0, "length": 158, "protein_name": "Ribonucleases P/MRP protein subunit POP6", "gene_name": "POP6", "organism": "Yeast", "refseq_name": "ribonuclease P/MRP protein subunit POP6", "refseq_ac": [ { "id": "NP_011544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011544", "type": "external" } ], "gene_names_uniprotkb": "POP6", "gene_names_refseq": "POP6", "protein_names_uniprotkb": "Ribonucleases P/MRP protein subunit POP6; 3.1.26.5; RNA-processing protein POP6; RNases P/MRP 18.2 kDa subunit", "protein_names_refseq": "ribonuclease P/MRP protein subunit POP6", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR030C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;14690591;15637077;17322287;24374639;9169869;9290212;9620854", "class_list": "", "function": "Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUG5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0004526 ribonuclease P activity;GO:0042134 rRNA primary transcript binding", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005697 telomerase holoenzyme complex;GO:0000172 ribonuclease MRP complex", "go_biological_process": "GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent;GO:0008033 tRNA processing;GO:0006364 rRNA processing;GO:0000460 maturation of 5.8S rRNA;GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P53218-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53223-1", "uniprot_id": [ { "id": "CAX4_YEAST", "url": "https://www.uniprot.org/uniprot/P53223", "type": "external" } ], "mass": 27649.0, "length": 239, "protein_name": "Dolichyldiphosphatase", "gene_name": "CAX4", "organism": "Yeast", "refseq_name": "dolichyldiphosphatase", "refseq_ac": [ { "id": "NP_011550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011550", "type": "external" } ], "gene_names_uniprotkb": "CAX4; CWH8", "gene_names_refseq": "CAX4; CWH8", "protein_names_uniprotkb": "Dolichyldiphosphatase; 3.6.1.43; Dolichyl pyrophosphate phosphatase", "protein_names_refseq": "dolichyldiphosphatase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR036C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10024662;11504728;16273108;16847258;17322287;24374639;9169869;9290212", "class_list": "", "function": "Non-essential protein which is required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUH3;Q45U47", "ec_number_list": [ { "id": "3.6.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.43", "type": "external" } ], "go_molecular_function": "GO:0042392 sphingosine-1-phosphate phosphatase activity;GO:0047874 dolichyldiphosphatase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008610 lipid biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P53223-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53236-1", "uniprot_id": [ { "id": "RSC1_YEAST", "url": "https://www.uniprot.org/uniprot/P53236", "type": "external" } ], "mass": 106669.0, "length": 928, "protein_name": "Chromatin structure-remodeling complex subunit RSC1", "gene_name": "RSC1", "organism": "Yeast", "refseq_name": "RSC subunit protein RSC1", "refseq_ac": [ { "id": "NP_011570", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011570", "type": "external" } ], "gene_names_uniprotkb": "RSC1", "gene_names_refseq": "RSC1", "protein_names_uniprotkb": "Chromatin structure-remodeling complex subunit RSC1; RSC complex subunit RSC1; Remodel the structure of chromatin complex subunit 1", "protein_names_refseq": "RSC subunit protein RSC1", "tax_id": 559292, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); extrahepatic bile duct adenocarcinoma (Disease Ontology:DOID:3495); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); lung small cell carcinoma (Disease Ontology:DOID:5409); Crohn's disease (Disease Ontology:DOID:8778); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YGR056W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10025404;10329629;10619019;12072455;12183366;12697820;12702296;14562106;16273108;17563356;18407956;19779198;21126336;23749301;24374639;32597660;33481703;33491328;34965436;8980231;9169869", "class_list": "", "function": "Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is involved in meiotic sporulation through regulating IME2 expression., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VUJ1;Q45U30", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0000785 chromatin;GO:0016586 RSC-type complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006302 double-strand break repair;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0006368 transcription elongation by RNA polymerase II;GO:0006337 nucleosome disassembly", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P53236-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53238-1", "uniprot_id": [ { "id": "PEF1_YEAST", "url": "https://www.uniprot.org/uniprot/P53238", "type": "external" } ], "mass": 38342.0, "length": 335, "protein_name": "Peflin", "gene_name": "PEF1", "organism": "Yeast", "refseq_name": "Pef1p", "refseq_ac": [ { "id": "NP_011572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011572", "type": "external" } ], "gene_names_uniprotkb": "PEF1", "gene_names_refseq": "PEF1", "protein_names_uniprotkb": "Peflin; Penta-EF hand domain-containing protein 1", "protein_names_refseq": "Pef1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR058W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;14562106;17640275;19779198;20702584;23749301;24374639;32597660;33481703;33491328;9169869", "class_list": "", "function": "Calcium-binding protein that is required for polar bud growth and cell wall abscission. Can also bind zinc ions., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUJ3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030427 site of polarized growth;GO:0005934 cellular bud tip", "go_biological_process": "GO:0003400 regulation of COPII vesicle coating;GO:0007120 axial cellular bud site selection;GO:0007121 bipolar cellular bud site selection", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53238-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53244-1", "uniprot_id": [ { "id": "ART5_YEAST", "url": "https://www.uniprot.org/uniprot/P53244", "type": "external" } ], "mass": 65477.0, "length": 586, "protein_name": "Arrestin-related trafficking adapter 5", "gene_name": "ART5", "organism": "Yeast", "refseq_name": "Art5p", "refseq_ac": [ { "id": "NP_011582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011582", "type": "external" } ], "gene_names_uniprotkb": "ART5", "gene_names_refseq": "ART5", "protein_names_uniprotkb": "Arrestin-related trafficking adapter 5", "protein_names_refseq": "Art5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR068C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "14562106;15665377;17551511;17951556;18407956;18976803;19779198;20702584;21126336;22106047;23749301;24374639;28270554;31208443;32597660;33481703;33491328;9169869", "class_list": "", "function": "May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUK2", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0070086 ubiquitin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P53244-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53252-1", "uniprot_id": [ { "id": "PIL1_YEAST", "url": "https://www.uniprot.org/uniprot/P53252", "type": "external" } ], "mass": 38349.0, "length": 339, "protein_name": "Sphingolipid long chain base-responsive protein PIL1", "gene_name": "PIL1", "organism": "Yeast", "refseq_name": "lipid-binding protein PIL1", "refseq_ac": [ { "id": "NP_011600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011600", "type": "external" } ], "gene_names_uniprotkb": "PIL1", "gene_names_refseq": "PIL1", "protein_names_uniprotkb": "Sphingolipid long chain base-responsive protein PIL1", "protein_names_refseq": "lipid-binding protein PIL1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR086C)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "14562095;14562106;15016821;15665377;17287358;17330950;17563356;17761666;18407956;19269952;19779198;19795423;19823750;20702584;21126336;21177495;22106047;22218487;23749301;24374639;30516470;32597660;33481703;33491328;9169869", "class_list": "", "function": "Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VUL8", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005811 lipid droplet;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0008104 intracellular protein localization;GO:0070941 eisosome assembly;GO:0097446 protein localization to eisosome filament", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P53252-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53255-1", "uniprot_id": [ { "id": "DRN1_YEAST", "url": "https://www.uniprot.org/uniprot/P53255", "type": "external" } ], "mass": 58206.0, "length": 507, "protein_name": "CWF19-like protein DRN1", "gene_name": "DRN1", "organism": "Yeast", "refseq_name": "Drn1p", "refseq_ac": [ { "id": "NP_011607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011607", "type": "external" } ], "gene_names_uniprotkb": "DRN1", "gene_names_refseq": "DRN1", "protein_names_uniprotkb": "CWF19-like protein DRN1; Debranching enzyme-associated ribonuclease 1", "protein_names_refseq": "Drn1p", "tax_id": 559292, "disease": "autosomal recessive spinocerebellar ataxia 17 (Disease Ontology:DOID:0080064)", "pathway": " (sce:YGR093W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562095;14562106;17563356;18407956;19779198;19795423;19823750;22932476;24374639;24919400;32597660;33481703;33491328;9169869", "class_list": "", "function": "Involved in branched RNA metabolism, modulating the turnover of lariat-intron pre-mRNAs by the lariat-debranching enzyme DBR1. Enhances the debranching activity of DBR1 in vitro., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUM5", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0061632 RNA lariat debranching enzyme activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0071014 post-mRNA release spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P53255-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53256-1", "uniprot_id": [ { "id": "RRP46_YEAST", "url": "https://www.uniprot.org/uniprot/P53256", "type": "external" } ], "mass": 24407.0, "length": 223, "protein_name": "Exosome complex component RRP46", "gene_name": "RRP46", "organism": "Yeast", "refseq_name": "exosome non-catalytic core subunit RRP46", "refseq_ac": [ { "id": "NP_011609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011609", "type": "external" } ], "gene_names_uniprotkb": "RRP46", "gene_names_refseq": "RRP46", "protein_names_uniprotkb": "Exosome complex component RRP46; Ribosomal RNA-processing protein 46", "protein_names_refseq": "exosome non-catalytic core subunit RRP46", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR095C); (R-SCE-429958); (R-SCE-450385); (R-SCE-450513); (R-SCE-6791226)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10465791;12748633;12837249;14562095;14562106;16829593;17173052;17174896;24374639;30181345;33481703;33491328;9169869", "class_list": "", "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP46 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUM7;Q6TQU1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000176 nuclear exosome (RNase complex);GO:0000177 cytoplasmic exosome (RNase complex)", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process;GO:0006396 RNA processing;GO:0016075 rRNA catabolic process;GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P53256-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53259-1", "uniprot_id": [ { "id": "PCP1_YEAST", "url": "https://www.uniprot.org/uniprot/P53259", "type": "external" } ], "mass": 38815.0, "length": 346, "protein_name": "Rhomboid protein 1, mitochondrial", "gene_name": "PCP1", "organism": "Yeast", "refseq_name": "rhomboid protease PCP1", "refseq_ac": [ { "id": "NP_011615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011615", "type": "external" } ], "gene_names_uniprotkb": "PCP1; MDM37; RBD1; UGO2", "gene_names_refseq": "MDM37; PCP1; RBD1; UGO2", "protein_names_uniprotkb": "Rhomboid protein 1, mitochondrial; 3.4.21.105; Mitochondrial distribution and morphology protein 37; Processing of cytochrome c peroxidase protein 1", "protein_names_refseq": "rhomboid protease PCP1", "tax_id": 559292, "disease": "myopia (Disease Ontology:DOID:11830); hyperinsulinism (Disease Ontology:DOID:2018); coronary artery disease (Disease Ontology:DOID:3393); breast carcinoma (Disease Ontology:DOID:3459); Leigh disease (Disease Ontology:DOID:3652); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YGR101W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11907266;12417197;12707284;12774122;12901865;14562095;15125685;24374639;38964378;9169869", "class_list": "", "function": "Mitochondrial rhomboid serine protease processing the mitochondrial membrane fusion regulator MGM1, and the cytochrome c peroxidase (CCP1). Required for TIM11 stability, ATP synthase complex assembly, mitochondrial morphology, cytochrome c (CYC1) storage and mitochondrial genome maintenance., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUN3", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0016485 protein processing;GO:0010821 regulation of mitochondrion organization;GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P53259-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53261-1", "uniprot_id": [ { "id": "PESC_YEAST", "url": "https://www.uniprot.org/uniprot/P53261", "type": "external" } ], "mass": 69877.0, "length": 605, "protein_name": "Pescadillo homolog", "gene_name": "NOP7", "organism": "Yeast", "refseq_name": "mRNA-binding ribosome synthesis protein NOP7", "refseq_ac": [ { "id": "NP_011617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011617", "type": "external" } ], "gene_names_uniprotkb": "NOP7; RRP13; YPH1", "gene_names_refseq": "NOP7; YPH1", "protein_names_uniprotkb": "Pescadillo homolog; Nucleolar protein 7; Ribosomal RNA-processing protein 13", "protein_names_refseq": "mRNA-binding ribosome synthesis protein NOP7", "tax_id": 559292, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479)", "pathway": " (sce:YGR103W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "11911362;12022229;12110181;14562106;16287855;16888624;17322287;17563356;18407956;18448671;19779198;21126336;23749301;24374639;30516470;32597660;33481703;33491328;9169869", "class_list": "", "function": "Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUN5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0042802 identical protein binding;GO:0043021 ribonucleoprotein complex binding;GO:0019843 rRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0070545 PeBoW complex", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0006364 rRNA processing;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P53261-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53262-1", "uniprot_id": [ { "id": "VOA1_YEAST", "url": "https://www.uniprot.org/uniprot/P53262", "type": "external" } ], "mass": 29678.0, "length": 265, "protein_name": "V0 assembly protein 1", "gene_name": "VOA1", "organism": "Yeast", "refseq_name": "Voa1p", "refseq_ac": [ { "id": "NP_011620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011620", "type": "external" } ], "gene_names_uniprotkb": "VOA1", "gene_names_refseq": "VOA1", "protein_names_uniprotkb": "V0 assembly protein 1", "protein_names_refseq": "Voa1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR106C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562095;14562106;18799613;24374639;29526695;9169869", "class_list": "", "function": "Accessory component of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:29526695). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:29526695). Functions with VMA21 in assembly of the V0 complex (PubMed:18799613)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VUN8", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0048388 endosomal lumen acidification;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport;GO:0065003 protein-containing complex assembly;GO:0061795 Golgi lumen acidification", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P53262-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53264-1", "uniprot_id": [ { "id": "CLD1_YEAST", "url": "https://www.uniprot.org/uniprot/P53264", "type": "external" } ], "mass": 52045.0, "length": 445, "protein_name": "Cardiolipin-specific deacylase 1, mitochondrial", "gene_name": "CLD1", "organism": "Yeast", "refseq_name": "carboxylic ester hydrolase", "refseq_ac": [ { "id": "NP_011625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011625", "type": "external" } ], "gene_names_uniprotkb": "CLD1; G6140", "gene_names_refseq": "CLD1", "protein_names_uniprotkb": "Cardiolipin-specific deacylase 1, mitochondrial; 3.5.1.-", "protein_names_refseq": "carboxylic ester hydrolase", "tax_id": 559292, "disease": "Chanarin-Dorfman syndrome (Disease Ontology:DOID:0050729); autosomal recessive congenital ichthyosis 1 (Disease Ontology:DOID:0060656); colon adenocarcinoma (Disease Ontology:DOID:234); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YGR110W); (R-SCE-1482839)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10601195;15878181;17322287;19244244;23637464;24318983;24374639;27603010;27982579;29935382;33491328;8905931;9169869", "class_list": "", "function": "Mitochondrial cardiolipin-specific phospholipase which deacylates de novo synthesized cardiolipin (CL). Part of the remodeling process of cardiolipin, which involves deacylation-reacylation of premature cardiolipin. Has a strong substrate preference for palmitic acid residues and generates monolysocardiolipin (MLCL) for TAZ1-dependent reacylation with unsaturated fatty acids (PubMed:19244244, PubMed:23637464). The hydrolytic selectivity of the enzyme toward C16-CL substrates contributes to the preservation of C18:1-containing CL species (PubMed:27982579). Has high specificity towards peroxidized cardiolipids CL(OX). Required to mitigate oxidative stress by removing CL(OX) (PubMed:29935382)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VUP3", "ec_number_list": [ { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006654 phosphatidic acid biosynthetic process;GO:0055088 lipid homeostasis;GO:0035965 cardiolipin acyl-chain remodeling;GO:0032048 cardiolipin metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P53264-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53271-1", "uniprot_id": [ { "id": "COG2_YEAST", "url": "https://www.uniprot.org/uniprot/P53271", "type": "external" } ], "mass": 30325.0, "length": 262, "protein_name": "Conserved oligomeric Golgi complex subunit 2", "gene_name": "COG2", "organism": "Yeast", "refseq_name": "Golgi transport complex subunit COG2", "refseq_ac": [ { "id": "NP_011635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011635", "type": "external" } ], "gene_names_uniprotkb": "COG2; G6324; SEC35", "gene_names_refseq": "COG2; SEC35", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 2; COG complex subunit 2; Component of oligomeric Golgi complex 2; Protein SEC35", "protein_names_refseq": "Golgi transport complex subunit COG2", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR120C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11703943;12006647;12011112;12748633;14562095;14562106;15047703;17565980;24374639;33491328;9046098;9169869;9606204", "class_list": "", "function": "Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. COG2 is required for ER to Golgi vesicle docking. Not essential for viability., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUQ1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0016236 macroautophagy;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0000301 retrograde transport, vesicle recycling within Golgi;GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P53271-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53276-1", "uniprot_id": [ { "id": "UTP8_YEAST", "url": "https://www.uniprot.org/uniprot/P53276", "type": "external" } ], "mass": 80191.0, "length": 713, "protein_name": "U3 small nucleolar RNA-associated protein 8", "gene_name": "UTP8", "organism": "Yeast", "refseq_name": "Utp8p", "refseq_ac": [ { "id": "NP_011644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011644", "type": "external" } ], "gene_names_uniprotkb": "UTP8", "gene_names_refseq": "UTP8", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 8; U three protein 8; U3 protein 8 required for transcription; U3 snoRNA-associated protein 8; t-UTP8", "protein_names_refseq": "Utp8p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR128C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "12068309;12794079;14562106;15489292;17330950;17563356;18407956;19779198;19795423;19823750;20702584;20884785;21126336;23749301;24374639;32597660;33481703;33491328;9169869", "class_list": "", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA. Also has a role in nuclear tRNA export. It acts between the steps of tRNA maturation/aminoacylation and its subsequent translocation out of the nucleus. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUR0", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0034511 U3 snoRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0033553 rDNA heterochromatin;GO:0034455 t-UTP complex;GO:0030686 90S preribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006409 tRNA export from nucleus;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P53276-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53281-1", "uniprot_id": [ { "id": "LSB1_YEAST", "url": "https://www.uniprot.org/uniprot/P53281", "type": "external" } ], "mass": 26139.0, "length": 241, "protein_name": "LAS seventeen-binding protein 1", "gene_name": "LSB1", "organism": "Yeast", "refseq_name": "Lsb1p", "refseq_ac": [ { "id": "NP_011652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011652", "type": "external" } ], "gene_names_uniprotkb": "LSB1", "gene_names_refseq": "LSB1", "protein_names_uniprotkb": "LAS seventeen-binding protein 1; LAS17-binding protein 1", "protein_names_refseq": "Lsb1p", "tax_id": 559292, "disease": "prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); prostate adenocarcinoma (Disease Ontology:DOID:2526); endometrial carcinoma (Disease Ontology:DOID:2871)", "pathway": " (sce:YGR136W); (R-SCE-9013420)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10407277;10512884;12872131;14557538;14562095;17287358;17551511;18407956;19795423;19823750;21777813;22000681;22106047;22814378;23749301;24374639;33481703;33491328;9169869", "class_list": "", "function": "Involved in resistance to EDTA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUR8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030479 actin cortical patch", "go_biological_process": "GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P53281-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53294-1", "uniprot_id": [ { "id": "PUS6_YEAST", "url": "https://www.uniprot.org/uniprot/P53294", "type": "external" } ], "mass": 46816.0, "length": 404, "protein_name": "tRNA pseudouridine(31) synthase", "gene_name": "PUS6", "organism": "Yeast", "refseq_name": "pseudouridine synthase PUS6", "refseq_ac": [ { "id": "NP_011685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011685", "type": "external" } ], "gene_names_uniprotkb": "PUS6", "gene_names_refseq": "PUS6", "protein_names_uniprotkb": "tRNA pseudouridine(31) synthase; 5.4.99.42; PSI31 synthase; Pseudouridine synthase 6; Pseudouridylate synthase 6; Uracil hydrolyase; tRNA pseudouridine 31 synthase", "protein_names_refseq": "pseudouridine synthase PUS6", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR169C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11406626;14562106;18407956;24374639;9169869;9290212", "class_list": "", "function": "Catalyzes the formation of pseudouridine at position 31 in the psi GC loop of tRNAS., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUV2", "ec_number_list": [ { "id": "5.4.99.42", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.42", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0009982 pseudouridine synthase activity;GO:0160152 tRNA pseudouridine(31) synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0031119 tRNA pseudouridine synthesis;GO:0000455 enzyme-directed rRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P53294-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53296-1", "uniprot_id": [ { "id": "ATF2_YEAST", "url": "https://www.uniprot.org/uniprot/P53296", "type": "external" } ], "mass": 61898.0, "length": 535, "protein_name": "Alcohol O-acetyltransferase 2", "gene_name": "ATF2", "organism": "Yeast", "refseq_name": "alcohol O-acetyltransferase", "refseq_ac": [ { "id": "NP_011693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011693", "type": "external" } ], "gene_names_uniprotkb": "ATF2; G7135", "gene_names_refseq": "ATF2", "protein_names_uniprotkb": "Alcohol O-acetyltransferase 2; 2.3.1.84; AATase 2; APAT; Acetyl-CoA:pregnenolone acetyltransferase", "protein_names_refseq": "alcohol O-acetyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR177C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10103065;12937998;12957907;14562106;16845703;17322287;17891501;18407956;24374639;25093817;33491328;9169869", "class_list": "", "function": "Can use acetyl-CoA to synthesize acetate esters from various alcohols, producing ethyl acetate, isoamyl acetate, isobutyl acetate, butyl acetate, hexyl acetate, heptyl acetate and octyl acetate (PubMed:12937998, PubMed:12957907, PubMed:16845703, PubMed:17891501). ATF2 seems to play only a minor role in the acetate ester synthesis, compared to ATF1 (PubMed:12957907). Plays an active role in the detoxification hydroxysteroids and possibly certain phytochemicals, in association with the efflux pumps PDR5 and SNQ2 (PubMed:10103065)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUW1;E9P955", "ec_number_list": [ { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "2.3.1.84", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.84", "type": "external" }, { "id": "3.1.2.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.20", "type": "external" } ], "go_molecular_function": "GO:0008080 N-acetyltransferase activity;GO:0004026 alcohol O-acetyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0009636 response to toxic substance;GO:0008202 steroid metabolic process;GO:1901089 acetate ester metabolic process involved in fermentation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P53296-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53297-1", "uniprot_id": [ { "id": "PBP1_YEAST", "url": "https://www.uniprot.org/uniprot/P53297", "type": "external" } ], "mass": 78781.0, "length": 722, "protein_name": "PAB1-binding protein 1", "gene_name": "PBP1", "organism": "Yeast", "refseq_name": "Pbp1p", "refseq_ac": [ { "id": "NP_011694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011694", "type": "external" } ], "gene_names_uniprotkb": "PBP1; MRS16", "gene_names_refseq": "MRS16; PBP1", "protein_names_uniprotkb": "PAB1-binding protein 1; Poly(A)-binding protein-binding protein", "protein_names_refseq": "Pbp1p", "tax_id": 559292, "disease": "spinocerebellar ataxia 2 (Disease Ontology:DOID:0050955); amyotrophic lateral sclerosis type 13 (Disease Ontology:DOID:0060204); late onset Parkinson's disease (Disease Ontology:DOID:0060892); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441)", "pathway": " (sce:YGR178C)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "14562095;14562106;14576278;15082763;15121841;16702403;17330950;17563356;18407956;19779198;19823750;20471941;20702584;21126336;21177495;22106047;22218487;23749301;24374639;30516470;31455721;32597660;33229814;33481703;33491328;9169869;9819425", "class_list": "", "function": "Involved in pre-mRNA polyadenylation (PubMed:15121841, PubMed:9819425). May act to repress the ability of PAB1 to negatively regulate polyadenylation (PubMed:9819425). Negative regulator of poly(A) nuclease (PAN) activity (PubMed:15121841). Promotes mating-type switching in mother cells by positively regulating HO mRNA translation (PubMed:15082763). Localizes MKT1 to polysomes (PubMed:15082763)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 28, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6VUW2", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005840 ribosome", "go_biological_process": "GO:0006417 regulation of translation;GO:0042149 cellular response to glucose starvation;GO:0045727 positive regulation of translation;GO:0034063 stress granule assembly;GO:1904262 negative regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P53297-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53298-1", "uniprot_id": [ { "id": "CENPQ_YEAST", "url": "https://www.uniprot.org/uniprot/P53298", "type": "external" } ], "mass": 47349.0, "length": 406, "protein_name": "Inner kinetochore subunit OKP1", "gene_name": "OKP1", "organism": "Yeast", "refseq_name": "Okp1p", "refseq_ac": [ { "id": "NP_011695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011695", "type": "external" } ], "gene_names_uniprotkb": "OKP1", "gene_names_refseq": "OKP1", "protein_names_uniprotkb": "Inner kinetochore subunit OKP1; CENP-Q homolog; Constitutive centromere-associated network protein OKP1; Outer kinetochore protein 1", "protein_names_refseq": "Okp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR179C)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10323865;12408861;14562095;14562106;14633972;14690591;17322287;18407956;19779198;19795423;19823750;20489023;21126336;22218487;22561346;23749301;24374639;29046335;30516470;32597660;33481703;33491328;9169869", "class_list": "", "function": "Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUW3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore;GO:0000817 COMA complex", "go_biological_process": "GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P53298-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53299-1", "uniprot_id": [ { "id": "TIM13_YEAST", "url": "https://www.uniprot.org/uniprot/P53299", "type": "external" } ], "mass": 11286.0, "length": 105, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM13", "gene_name": "TIM13", "organism": "Yeast", "refseq_name": "protein translocase subunit TIM13", "refseq_ac": [ { "id": "NP_011697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011697", "type": "external" } ], "gene_names_uniprotkb": "TIM13; G7157", "gene_names_refseq": "TIM13", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM13", "protein_names_refseq": "protein translocase subunit TIM13", "tax_id": 559292, "disease": "deafness-dystonia-optic neuronopathy syndrome (Disease Ontology:DOID:0050757)", "pathway": " (sce:YGR181W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10469659;10995434;11101512;11509656;12221072;12941692;17322287;19779198;22984289;24374639;33481703;33491328;9133739;9169869", "class_list": "", "function": "Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins under precise conditions while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins. Strictly required for import of TIM23 in some conditions, when a low membrane potential exists in the mitochondria., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUW5", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0042719 mitochondrial intermembrane space chaperone complex;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0015031 protein transport;GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P53299-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53301-1", "uniprot_id": [ { "id": "CRH1_YEAST", "url": "https://www.uniprot.org/uniprot/P53301", "type": "external" } ], "mass": 52758.0, "length": 507, "protein_name": "Congo red hypersensitive protein 1", "gene_name": "CRH1", "organism": "Yeast", "refseq_name": "transglycosylase", "refseq_ac": [ { "id": "NP_011705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011705", "type": "external" } ], "gene_names_uniprotkb": "CRH1; G7553", "gene_names_refseq": "CRH1", "protein_names_uniprotkb": "Congo red hypersensitive protein 1", "protein_names_refseq": "transglycosylase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR189C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10594829;10757808;11016834;15781460;17302808;17617218;18694928;19734368;23919454;24374639;31870255;32597660;33491328;9133739;9169869;9613572", "class_list": "glycogene;glycosylhydrolase", "function": "Dual chitinase/transglycosylase that plays a role in cell wall architecture (PubMed:18694928, PubMed:19734368, PubMed:23919454). Chitinase and transglycosylase activities are coupled (By similarity). Required for the polysaccharide cross-linking at the septa and the cell wall (PubMed:18694928, PubMed:19734368, PubMed:23919454). More specifically, transfers chitin to both beta(1-3)- and beta(1-6)glucan in the cell wall (PubMed:18694928, PubMed:19734368, PubMed:23919454). The minimal number of intact hexopyranose units required in the molecule of the acceptor oligosaccharide is two and the effectivity of the acceptor increased with the increasing length of its oligosaccharide chain (PubMed:23919454)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VUX2", "ec_number_list": [], "go_molecular_function": "GO:0016757 glycosyltransferase activity;GO:0008843 endochitinase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0071944 cell periphery;GO:0000131 incipient cellular bud site;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006030 chitin metabolic process;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P53301-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000010001.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53303-1", "uniprot_id": [ { "id": "ZPR1_YEAST", "url": "https://www.uniprot.org/uniprot/P53303", "type": "external" } ], "mass": 55072.0, "length": 486, "protein_name": "Zinc finger chaperone ZPR1", "gene_name": "ZPR1", "organism": "Yeast", "refseq_name": "zinc finger-containing protein ZPR1", "refseq_ac": [ { "id": "NP_011727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011727", "type": "external" } ], "gene_names_uniprotkb": "ZPR1", "gene_names_refseq": "ZPR1", "protein_names_uniprotkb": "Zinc finger chaperone ZPR1", "protein_names_refseq": "zinc finger-containing protein ZPR1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR211W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14562106;18407956;19779198;19795423;19823750;20190278;21126336;24374639;32597660;33481703;33491328;34965436;36630955;9169869;9290212;9852145", "class_list": "", "function": "Acts as a protein folding chaperone for elongation factor 1-alpha., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUZ4;Q02807;Q02808", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061770 translation elongation factor binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000086 G2/M transition of mitotic cell cycle;GO:0006457 protein folding;GO:0009749 response to glucose;GO:0006458 'de novo' protein folding", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P53303-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53309-1", "uniprot_id": [ { "id": "AP18B_YEAST", "url": "https://www.uniprot.org/uniprot/P53309", "type": "external" } ], "mass": 64328.0, "length": 568, "protein_name": "Clathrin coat assembly protein AP180B", "gene_name": "YAP1802", "organism": "Yeast", "refseq_name": "Yap1802p", "refseq_ac": [ { "id": "NP_011757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011757", "type": "external" } ], "gene_names_uniprotkb": "YAP1802; G8610", "gene_names_refseq": "YAP1802", "protein_names_uniprotkb": "Clathrin coat assembly protein AP180B", "protein_names_refseq": "Yap1802p", "tax_id": 559292, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); middle cerebral artery infarction (Disease Ontology:DOID:3525); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (sce:YGR241C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562095;14562106;14704157;18407956;19779198;22106047;23749301;24374639;24909858;33481703;33491328;9090057;9169869;9531549", "class_list": "", "function": "Involved in endocytosis and clathrin cage assembly., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VV22", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005545 1-phosphatidylinositol binding;GO:0030276 clathrin binding;GO:0000149 SNARE binding;GO:0032050 clathrin heavy chain binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0030136 clathrin-coated vesicle;GO:0005628 prospore membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0006900 vesicle budding from membrane;GO:0048268 clathrin coat assembly;GO:0072583 clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P53309-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53311-1", "uniprot_id": [ { "id": "MPC3_YEAST", "url": "https://www.uniprot.org/uniprot/P53311", "type": "external" } ], "mass": 16230.0, "length": 146, "protein_name": "Mitochondrial pyruvate carrier 3", "gene_name": "MPC3", "organism": "Yeast", "refseq_name": "mitochondrial pyruvate carrier", "refseq_ac": [ { "id": "NP_011759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011759", "type": "external" } ], "gene_names_uniprotkb": "MPC3; FMP43; G8620", "gene_names_refseq": "FMP43; MPC3", "protein_names_uniprotkb": "Mitochondrial pyruvate carrier 3; MPC3; Protein FMP43", "protein_names_refseq": "mitochondrial pyruvate carrier", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR243W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562095;14562106;14576278;15299026;16087739;17322287;17334841;22628554;22628558;24374639;25672363;30979775;9090057;9169869", "class_list": "", "function": "Together with MPC1, mediates the mitochondrial uptake of pyruvate under respiratory conditions., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV23", "ec_number_list": [], "go_molecular_function": "GO:0050833 pyruvate transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005777 peroxisome;GO:0031966 mitochondrial membrane;GO:7770001 mitochondrial pyruvate carrier complex", "go_biological_process": "GO:0006850 pyruvate import into mitochondria", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P53311-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53314-1", "uniprot_id": [ { "id": "CPD1_YEAST", "url": "https://www.uniprot.org/uniprot/P53314", "type": "external" } ], "mass": 26732.0, "length": 239, "protein_name": "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "gene_name": "CPD1", "organism": "Yeast", "refseq_name": "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "refseq_ac": [ { "id": "NP_011763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011763", "type": "external" } ], "gene_names_uniprotkb": "CPD1", "gene_names_refseq": "CPD1", "protein_names_uniprotkb": "2',3'-cyclic-nucleotide 3'-phosphodiesterase; 3.1.4.37; CPDase", "protein_names_refseq": "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR247W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10734185;14562095;14562106;17322287;24374639;33491328;7929175;9133742;9169869", "class_list": "", "function": "Involved in the metabolism of ADP-ribose 1',2'-cyclic phosphate which is produced as a consequence of tRNA splicing., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV27", "ec_number_list": [ { "id": "3.1.4.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.37", "type": "external" } ], "go_molecular_function": "GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0009187 cyclic nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P53314-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53324-1", "uniprot_id": [ { "id": "SAY1_YEAST", "url": "https://www.uniprot.org/uniprot/P53324", "type": "external" } ], "mass": 48541.0, "length": 424, "protein_name": "Steryl acetyl hydrolase 1", "gene_name": "SAY1", "organism": "Yeast", "refseq_name": "steryl deacetylase", "refseq_ac": [ { "id": "NP_011779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011779", "type": "external" } ], "gene_names_uniprotkb": "SAY1", "gene_names_refseq": "SAY1", "protein_names_uniprotkb": "Steryl acetyl hydrolase 1; 3.1.1.-", "protein_names_refseq": "steryl deacetylase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR263C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18034159;22814378;24374639;33491328;9090059;9169869", "class_list": "", "function": "Required for the deacetylation of acetylated sterols. Involved in the resistance to eugenol and pregnenolone toxicity., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VV42", "ec_number_list": [], "go_molecular_function": "GO:0034084 steryl deacetylase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005811 lipid droplet;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0009636 response to toxic substance;GO:0016125 sterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P53324-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53327-1", "uniprot_id": [ { "id": "ASCC3_YEAST", "url": "https://www.uniprot.org/uniprot/P53327", "type": "external" } ], "mass": 224850.0, "length": 1967, "protein_name": "RQC trigger complex helicase SLH1", "gene_name": "SLH1", "organism": "Yeast", "refseq_name": "RNA helicase", "refseq_ac": [ { "id": "NP_011787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011787", "type": "external" } ], "gene_names_uniprotkb": "SLH1; G9365; RQT2", "gene_names_refseq": "RQT2; SLH1", "protein_names_uniprotkb": "RQC trigger complex helicase SLH1; 3.6.4.13; Antiviral helicase SLH1; SKI2-like helicase 1", "protein_names_refseq": "RNA helicase", "tax_id": 559292, "disease": "autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308)", "pathway": " (sce:YGR271W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10922069;11438647;14562095;14562106;19795423;19823750;21126336;24374639;28223409;28757607;30893611;32203490;33481703;33491328;9133744;9169869", "class_list": "", "function": "Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:28223409, PubMed:28757607, PubMed:30893611, PubMed:32203490). Drives the splitting of stalled ribosomes that are polyubiquitinated in a HEL2-dependent manner, as part of the ribosome quality control trigger (RQT) complex (PubMed:28757607, PubMed:30893611, PubMed:32203490). Also represses the translation of non-poly(A) mRNAs together with SKI2 (PubMed:10922069). May block translation by inhibiting translation initiation factor 5B (FUN12) action on mRNAs lacking a 3' poly(A) structure (PubMed:11438647). Involved in antiviral defense, preventing L-A dsRNA virus propagation by specifically blocking translation of viral mRNAs (PubMed:10922069)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV48", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004386 helicase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0006417 regulation of translation;GO:0051607 defense response to virus;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P53327-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53334-1", "uniprot_id": [ { "id": "SCW4_YEAST", "url": "https://www.uniprot.org/uniprot/P53334", "type": "external" } ], "mass": 40173.0, "length": 386, "protein_name": "Probable family 17 glucosidase SCW4", "gene_name": "SCW4", "organism": "Yeast", "refseq_name": "putative family 17 glucosidase", "refseq_ac": [ { "id": "NP_011795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011795", "type": "external" } ], "gene_names_uniprotkb": "SCW4", "gene_names_refseq": "SCW4", "protein_names_uniprotkb": "Probable family 17 glucosidase SCW4; 3.2.1.-; Soluble cell wall protein 4", "protein_names_refseq": "putative family 17 glucosidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR279C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17617218;19756047;24374639;33167499;9090054;9169869;9748433", "class_list": "glycogene;glycosylhydrolase", "function": "Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VV56", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0015926 glucosidase activity;GO:0042973 glucan endo-1,3-beta-D-glucosidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface;GO:0005773 vacuole;GO:0000324 fungal-type vacuole;GO:0009277 fungal-type cell wall", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0000747 conjugation with cellular fusion;GO:0071555 cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P53334-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000011001.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53337-1", "uniprot_id": [ { "id": "ERV29_YEAST", "url": "https://www.uniprot.org/uniprot/P53337", "type": "external" } ], "mass": 35013.0, "length": 310, "protein_name": "ER-derived vesicles protein ERV29", "gene_name": "ERV29", "organism": "Yeast", "refseq_name": "protein ERV29", "refseq_ac": [ { "id": "NP_011800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011800", "type": "external" } ], "gene_names_uniprotkb": "ERV29", "gene_names_refseq": "ERV29", "protein_names_uniprotkb": "ER-derived vesicles protein ERV29", "protein_names_refseq": "protein ERV29", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR284C); (R-SCE-6798695); (R-SCE-6811434)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "11157978;11711675;15516922;16847258;17322287;17520482;18407956;23749301;24374639;33481703;33491328;9090054;9169869", "class_list": "", "function": "Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. The C-terminal di-lysine motif is required for exit from the endoplasmic reticulum. Required directly for packaging glycosylated pro-alpha-factor into COPII vesicles. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV61;E9P8T4", "ec_number_list": [], "go_molecular_function": "GO:0097020 COPII receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P53337-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53378-1", "uniprot_id": [ { "id": "TBG_YEAST", "url": "https://www.uniprot.org/uniprot/P53378", "type": "external" } ], "mass": 52627.0, "length": 473, "protein_name": "Tubulin gamma chain", "gene_name": "TUB4", "organism": "Yeast", "refseq_name": "gamma-tubulin", "refseq_ac": [ { "id": "NP_013313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013313", "type": "external" } ], "gene_names_uniprotkb": "TUB4; L8167.21", "gene_names_refseq": "TUB4", "protein_names_uniprotkb": "Tubulin gamma chain; Gamma-tubulin", "protein_names_refseq": "gamma-tubulin", "tax_id": 559292, "disease": "muscular disease (Disease Ontology:DOID:0080000); complex cortical dysplasia with other brain malformations 4 (Disease Ontology:DOID:0090138); inclusion body myositis (Disease Ontology:DOID:3429)", "pathway": " (sce:YLR212C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11709183;14562106;21573187;24374639;28900268;29903865;8557744;8707827;9169871;9670012", "class_list": "", "function": "Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. TUB4 is an important spindle pole body component that organizes both cytoplasmic and nuclear microtubule arrays., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYL3", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0140490 microtubule nucleator activity", "go_cellular_component": "GO:0008275 gamma-tubulin small complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005874 microtubule", "go_biological_process": "GO:2000767 positive regulation of cytoplasmic translation;GO:0010968 regulation of microtubule nucleation;GO:0000278 mitotic cell cycle;GO:0007020 microtubule nucleation;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P53378-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53379-1", "uniprot_id": [ { "id": "MKC7_YEAST", "url": "https://www.uniprot.org/uniprot/P53379", "type": "external" } ], "mass": 64269.0, "length": 596, "protein_name": "Aspartic proteinase MKC7", "gene_name": "MKC7", "organism": "Yeast", "refseq_name": "aspartyl protease", "refseq_ac": [ { "id": "NP_010428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010428", "type": "external" } ], "gene_names_uniprotkb": "MKC7; YD2943.03C; YD8358.01C; YPS2", "gene_names_refseq": "MKC7; YPS2", "protein_names_uniprotkb": "Aspartic proteinase MKC7; 3.4.23.41; Yapsin-2", "protein_names_refseq": "aspartyl protease", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR144C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10446224;14562106;16087741;19779198;24374639;7479877;9169867", "class_list": "", "function": "Cleaves proteins C-terminally to the most C-terminal basic residue. Can process the alpha-mating factor precursor. Required for cell wall integrity., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "D6VSC7", "ec_number_list": [], "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0000324 fungal-type vacuole;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0016485 protein processing;GO:0001402 signal transduction involved in filamentous growth;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P53379-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53397-1", "uniprot_id": [ { "id": "OGG1_YEAST", "url": "https://www.uniprot.org/uniprot/P53397", "type": "external" } ], "mass": 42781.0, "length": 376, "protein_name": "N-glycosylase/DNA lyase", "gene_name": "OGG1", "organism": "Yeast", "refseq_name": "8-oxoguanine glycosylase OGG1", "refseq_ac": [ { "id": "NP_013651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013651", "type": "external" } ], "gene_names_uniprotkb": "OGG1; YM9958.02", "gene_names_refseq": "OGG1", "protein_names_uniprotkb": "N-glycosylase/DNA lyase", "protein_names_refseq": "8-oxoguanine glycosylase OGG1", "tax_id": 559292, "disease": "pterygium (Disease Ontology:DOID:0002116); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); gestational diabetes (Disease Ontology:DOID:11714); Graves' disease (Disease Ontology:DOID:12361); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); hepatitis (Disease Ontology:DOID:2237); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); basal cell carcinoma (Disease Ontology:DOID:2513); transitional cell carcinoma (Disease Ontology:DOID:2671); angiomyolipoma (Disease Ontology:DOID:3314); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); progressive supranuclear palsy (Disease Ontology:DOID:678); cataract (Disease Ontology:DOID:83); type 2 diabetes mellitus (Disease Ontology:DOID:9352); senile cataract (Disease Ontology:DOID:9669)", "pathway": " (sce:YML060W); (R-SCE-110329); (R-SCE-110330); (R-SCE-110331)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10677220;14562106;24374639;33491328;8643552;9169872;9241232", "class_list": "", "function": "DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZB3", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity;GO:0003684 damaged DNA binding;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006281 DNA repair;GO:0006289 nucleotide-excision repair;GO:0007004 telomere maintenance via telomerase;GO:0006285 base-excision repair, AP site formation;GO:0070987 error-free translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P53397-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53507-1", "uniprot_id": [ { "id": "TOM7_YEAST", "url": "https://www.uniprot.org/uniprot/P53507", "type": "external" } ], "mass": 6870.0, "length": 60, "protein_name": "Mitochondrial import receptor subunit TOM7", "gene_name": "TOM7", "organism": "Yeast", "refseq_name": "Tom7p", "refseq_ac": [ { "id": "NP_014329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014329", "type": "external" } ], "gene_names_uniprotkb": "TOM7; MOM7; N2378", "gene_names_refseq": "MOM7; TOM7; YOK22", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM7; Translocase of outer membrane 7 kDa subunit", "protein_names_refseq": "Tom7p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL070W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11276259;14562106;17322287;22814378;24374639;8641278;8701611;9169873;9774667", "class_list": "", "function": "Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM7 is involved in assembly and stability of the TOM complex., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1A9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005742 mitochondrial outer membrane translocase complex", "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P53507-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53538-1", "uniprot_id": [ { "id": "SSU72_YEAST", "url": "https://www.uniprot.org/uniprot/P53538", "type": "external" } ], "mass": 23469.0, "length": 206, "protein_name": "RNA polymerase II subunit A C-terminal domain phosphatase SSU72", "gene_name": "SSU72", "organism": "Yeast", "refseq_name": "RNA polymerase II subunit A C-terminal domain phosphatase", "refseq_ac": [ { "id": "NP_014177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014177", "type": "external" } ], "gene_names_uniprotkb": "SSU72; N1279", "gene_names_refseq": "SSU72", "protein_names_uniprotkb": "RNA polymerase II subunit A C-terminal domain phosphatase SSU72; 3.1.3.16; CTD phosphatase SSU72; Suppressor of SUA7 protein 2", "protein_names_refseq": "RNA polymerase II subunit A C-terminal domain phosphatase", "tax_id": 559292, "disease": "liver disease (Disease Ontology:DOID:409)", "pathway": " (sce:YNL222W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12660165;12819204;15125841;17322287;18407956;19779198;20489023;24374639;33491328;8657130;9169873", "class_list": "", "function": "Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation. SSU72 is required for 3'-end formation of snoRNAs., [UniProtKB]; Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0W8;Q6Q569", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.43", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0006369 termination of RNA polymerase II transcription;GO:0031124 mRNA 3'-end processing;GO:0001174 transcriptional start site selection at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53538-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53540-1", "uniprot_id": [ { "id": "SPC98_YEAST", "url": "https://www.uniprot.org/uniprot/P53540", "type": "external" } ], "mass": 98227.0, "length": 846, "protein_name": "Spindle pole body component SPC98", "gene_name": "SPC98", "organism": "Yeast", "refseq_name": "Spc98p", "refseq_ac": [ { "id": "NP_014273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014273", "type": "external" } ], "gene_names_uniprotkb": "SPC98; N1222; N1879", "gene_names_refseq": "SPC98", "protein_names_uniprotkb": "Spindle pole body component SPC98", "protein_names_refseq": "Spc98p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL126W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11875433;14562106;18407956;19779198;23749301;24374639;29903865;33481703;33491328;8619318;8670895;9090055;9169873;9670012", "class_list": "", "function": "Involved in microtubule organization by the microtubule organizing center, the spindle pole body (SPB). Probably part of the microtubule attachment site at the SPB., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W157", "ec_number_list": [], "go_molecular_function": "GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0008275 gamma-tubulin small complex;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005874 microtubule;GO:0000930 gamma-tubulin complex", "go_biological_process": "GO:0010968 regulation of microtubule nucleation;GO:0000278 mitotic cell cycle;GO:0007020 microtubule nucleation;GO:0051225 spindle assembly;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P53540-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53541-1", "uniprot_id": [ { "id": "SPO1_YEAST", "url": "https://www.uniprot.org/uniprot/P53541", "type": "external" } ], "mass": 72187.0, "length": 631, "protein_name": "Putative meiotic phospholipase SPO1", "gene_name": "SPO1", "organism": "Yeast", "refseq_name": "putative carboxylic ester hydrolase", "refseq_ac": [ { "id": "NP_014386", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014386", "type": "external" } ], "gene_names_uniprotkb": "SPO1; N2858", "gene_names_refseq": "SPO1", "protein_names_uniprotkb": "Putative meiotic phospholipase SPO1; 3.1.1.-; Sporulation-specific protein 1", "protein_names_refseq": "putative carboxylic ester hydrolase", "tax_id": 559292, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); brain ischemia (Disease Ontology:DOID:2316); papilloma (Disease Ontology:DOID:2615); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); hyperglycemia (Disease Ontology:DOID:4195)", "pathway": " (sce:YNL012W); (R-SCE-111995); (R-SCE-1482788); (R-SCE-1482798); (R-SCE-1482801); (R-SCE-1482839); (R-SCE-1482922); (R-SCE-1482925); (R-SCE-1483115); (R-SCE-1483152); (R-SCE-1483166); (R-SCE-2142753); (R-SCE-418592); (R-SCE-432142); (R-SCE-6811436)", "pathway_count": 15, "publication_count": 6, "publication_id_list": "10734188;10855497;17179081;24374639;8921875;9169873", "class_list": "", "function": "Regulates spindle pole duplication in meiosis I, but not in mitosis. Required for meiosis I, meiosis II chromosome segregation and spore formation. Binds phosphatidylinositol (4)P mono- and polyphosphates., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "D6W1G5", "ec_number_list": [ { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0004620 phospholipase activity;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0046475 glycerophospholipid catabolic process;GO:0007127 meiosis I;GO:0030474 spindle pole body duplication;GO:0032120 ascospore-type prospore membrane formation;GO:0070583 spore membrane bending pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P53541-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53551-1", "uniprot_id": [ { "id": "H1_YEAST", "url": "https://www.uniprot.org/uniprot/P53551", "type": "external" } ], "mass": 27804.0, "length": 258, "protein_name": "Histone H1", "gene_name": "HHO1", "organism": "Yeast", "refseq_name": "histone H1", "refseq_ac": [ { "id": "NP_015198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015198", "type": "external" } ], "gene_names_uniprotkb": "HHO1; LPI17C", "gene_names_refseq": "HHO1", "protein_names_uniprotkb": "Histone H1", "protein_names_refseq": "histone H1", "tax_id": 559292, "disease": "acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (sce:YPL127C)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "14562106;17322287;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;30516470;31821952;32597660;33481703;33491328;33502312;8772381;9046096;9169875", "class_list": "", "function": "Could act as an H1-type linker histone. Has been shown to bind DNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3P0;Q6Q5R6", "ec_number_list": [], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0003676 nucleic acid binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0032993 protein-DNA complex;GO:0000786 nucleosome", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination;GO:2000779 regulation of double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P53551-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53552-1", "uniprot_id": [ { "id": "THO2_YEAST", "url": "https://www.uniprot.org/uniprot/P53552", "type": "external" } ], "mass": 183931.0, "length": 1597, "protein_name": "THO complex subunit 2", "gene_name": "THO2", "organism": "Yeast", "refseq_name": "Tho2p", "refseq_ac": [ { "id": "NP_014260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014260", "type": "external" } ], "gene_names_uniprotkb": "THO2; LDB5; N1209; N1835; RLR1; ZRG13", "gene_names_refseq": "LDB5; RLR1; THO2; ZRG13", "protein_names_uniprotkb": "THO complex subunit 2; Low dye-binding protein 5; THO complex subunit RLR1; Zinc-regulated gene 13 protein", "protein_names_refseq": "Tho2p", "tax_id": 559292, "disease": "X-linked intellectual disability-short stature-overweight syndrome (Disease Ontology:DOID:0112056)", "pathway": " (sce:YNL139C)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10675628;11060033;11979277;12093753;12871933;14527416;14562095;14562106;15192704;15665377;18407956;19795423;19823750;21126336;23749301;24374639;32597660;33229814;33481703;33491328;8619318;9169873;9707445", "class_list": "", "function": "Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W142", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000445 THO complex part of transcription export complex;GO:0000781 chromosome, telomeric region;GO:0000446 nucleoplasmic THO complex", "go_biological_process": "GO:0006310 DNA recombination;GO:0006406 mRNA export from nucleus;GO:0006368 transcription elongation by RNA polymerase II;GO:0006283 transcription-coupled nucleotide-excision repair;GO:0097185 cellular response to azide", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P53552-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53598-1", "uniprot_id": [ { "id": "SUCA_YEAST", "url": "https://www.uniprot.org/uniprot/P53598", "type": "external" } ], "mass": 35032.0, "length": 329, "protein_name": "Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial", "gene_name": "LSC1", "organism": "Yeast", "refseq_name": "succinate--CoA ligase (GDP-forming) subunit alpha", "refseq_ac": [ { "id": "NP_014785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014785", "type": "external" } ], "gene_names_uniprotkb": "LSC1; YOR3352W", "gene_names_refseq": "LSC1", "protein_names_uniprotkb": "Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; 6.2.1.5; SCS-alpha; Succinyl-CoA synthetase subunit alpha", "protein_names_refseq": "succinate--CoA ligase (GDP-forming) subunit alpha", "tax_id": 559292, "disease": "mitochondrial DNA depletion syndrome 9 (Disease Ontology:DOID:0080128)", "pathway": " (sce:YOR142W); (R-SCE-71403)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "14562095;14562106;14576278;17761666;18407956;23749301;24374639;33481703;33491328;9169874;9200815;9874242", "class_list": "", "function": "Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:9874242). The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit (By similarity)., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2J8", "ec_number_list": [ { "id": "6.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.5", "type": "external" } ], "go_molecular_function": "GO:0000166 nucleotide binding;GO:0004775 succinate-CoA ligase (ADP-forming) activity;GO:0004776 succinate-CoA ligase (GDP-forming) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:0009361 succinate-CoA ligase complex (ADP-forming)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006104 succinyl-CoA metabolic process;GO:1901289 succinyl-CoA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P53598-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53599-1", "uniprot_id": [ { "id": "SSK2_YEAST", "url": "https://www.uniprot.org/uniprot/P53599", "type": "external" } ], "mass": 180528.0, "length": 1579, "protein_name": "MAP kinase kinase kinase SSK2", "gene_name": "SSK2", "organism": "Yeast", "refseq_name": "mitogen-activated protein kinase kinase kinase SSK2", "refseq_ac": [ { "id": "NP_014428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014428", "type": "external" } ], "gene_names_uniprotkb": "SSK2; N3276", "gene_names_refseq": "SSK2", "protein_names_uniprotkb": "MAP kinase kinase kinase SSK2; 2.7.11.25; Suppressor of sensor kinase 2", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase SSK2", "tax_id": 559292, "disease": "", "pathway": " (sce:YNR031C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "14562106;17330950;18407956;19684113;19779198;20489023;20702584;21126336;21177495;23749301;24374639;25734609;28270554;32597660;33481703;33491328;7624781;9169873;9482735", "class_list": "", "function": "Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 36, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1K5", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0005524 ATP binding;GO:0004709 MAP kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005938 cell cortex;GO:0000131 incipient cellular bud site;GO:0005934 cellular bud tip;GO:0005935 cellular bud neck", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0051403 stress-activated MAPK cascade;GO:0071474 cellular hyperosmotic response;GO:0038066 p38MAPK cascade;GO:0007234 osmosensory signaling via phosphorelay pathway", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P53599-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53615-1", "uniprot_id": [ { "id": "CAN_YEAST", "url": "https://www.uniprot.org/uniprot/P53615", "type": "external" } ], "mass": 24859.0, "length": 221, "protein_name": "Carbonic anhydrase", "gene_name": "NCE103", "organism": "Yeast", "refseq_name": "carbonate dehydratase NCE103", "refseq_ac": [ { "id": "NP_014362", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014362", "type": "external" } ], "gene_names_uniprotkb": "NCE103; N2695; NCE3", "gene_names_refseq": "NCE103; NCE3", "protein_names_uniprotkb": "Carbonic anhydrase; 4.2.1.1; Carbonate dehydratase; Non-classical export protein 3", "protein_names_refseq": "carbonate dehydratase NCE103", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL036W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10407265;14562095;14562106;15096093;15780657;15813743;15948716;18993072;19852838;22984289;24374639;33491328;8655575;9169873", "class_list": "", "function": "Catalyzes the reversible hydration of CO(2) to H(2)CO(3). The main role may be to provide inorganic carbon for the bicarbonate-dependent carboxylation reactions catalyzed by pyruvate carboxylase, acetyl-CoA carboxylase and carbamoyl-phosphate synthetase. Involved in protection against oxidative damage. Encodes a substrate for the non-classical protein export pathway for proteins that lack a cleavable signal sequence., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1E3", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0071244 cellular response to carbon dioxide;GO:0015976 carbon utilization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P53615-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53616-1", "uniprot_id": [ { "id": "SUN4_YEAST", "url": "https://www.uniprot.org/uniprot/P53616", "type": "external" } ], "mass": 43442.0, "length": 420, "protein_name": "Probable secreted beta-glucosidase SUN4", "gene_name": "SUN4", "organism": "Yeast", "refseq_name": "putative glucosidase SUN4", "refseq_ac": [ { "id": "NP_014333", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014333", "type": "external" } ], "gene_names_uniprotkb": "SUN4; N2411; SCW3; YNL2411W", "gene_names_refseq": "SCW3; SUN4", "protein_names_uniprotkb": "Probable secreted beta-glucosidase SUN4; 3.2.1.-; Septation protein SUN4; Soluble cell wall protein 3", "protein_names_refseq": "putative glucosidase SUN4", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL066W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10870102;14562106;17244705;17322287;24040106;24374639;33491328;8533472;8701611;9169873;9748433", "class_list": "glycogene;glycosylhydrolase", "function": "Involved in the remodeling of the cell wall during the various phases of yeast culture development and under various environmental conditions and plays a role in septation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2TBM4;D6W1B4;Q6B1F2;Q870H0", "ec_number_list": [], "go_molecular_function": "GO:0015926 glucosidase activity", "go_cellular_component": "GO:0009986 cell surface;GO:0005621 cellular bud scar;GO:0009277 fungal-type cell wall", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0000272 polysaccharide catabolic process;GO:0000917 division septum assembly;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53616-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000010001.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53685-1", "uniprot_id": [ { "id": "HST1_YEAST", "url": "https://www.uniprot.org/uniprot/P53685", "type": "external" } ], "mass": 57702.0, "length": 503, "protein_name": "NAD-dependent protein deacetylase HST1", "gene_name": "HST1", "organism": "Yeast", "refseq_name": "histone deacetylase HST1", "refseq_ac": [ { "id": "NP_014573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014573", "type": "external" } ], "gene_names_uniprotkb": "HST1", "gene_names_refseq": "HST1", "protein_names_uniprotkb": "NAD-dependent protein deacetylase HST1; 2.3.1.286; Homologous to SIR2 protein 1; Regulatory protein SIR2 homolog 1", "protein_names_refseq": "histone deacetylase HST1", "tax_id": 559292, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); prostate cancer (Disease Ontology:DOID:10283); osteoporosis (Disease Ontology:DOID:11476); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); Huntington's disease (Disease Ontology:DOID:12858); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); acute kidney failure (Disease Ontology:DOID:3021); middle cerebral artery infarction (Disease Ontology:DOID:3525); macular degeneration (Disease Ontology:DOID:4448); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); senile cataract (Disease Ontology:DOID:9669); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (sce:YOL068C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10562556;10841563;11711434;12612074;12972620;14562095;14562106;23749301;24374639;30377154;33491328;7498786;8810037;9169874;9178509", "class_list": "", "function": "NAD-dependent histone deacetylase involved in telomeric silencing. Histone deacetylase proteins act via the formation of large multiprotein complexes that are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Restores silencing at HMR in SIR2 mutants when overexpressed. Required to repress middle sporulation genes during vegetative growth. Acts as a sensor of NAD(+) levels and regulator of NAD(+) biosynthesis. Regulates the gene expression of de novo NAD(+) biosynthesis genes., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1Z9", "ec_number_list": [ { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" } ], "go_molecular_function": "GO:0046970 histone H4K16 deacetylase activity, NAD-dependent;GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity;GO:0070403 NAD+ binding;GO:0017136 histone deacetylase activity, NAD-dependent", "go_cellular_component": "GO:0005634 nucleus;GO:0000781 chromosome, telomeric region;GO:0034967 Set3 complex", "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0031509 subtelomeric heterochromatin formation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P53685-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53687-1", "uniprot_id": [ { "id": "HST3_YEAST", "url": "https://www.uniprot.org/uniprot/P53687", "type": "external" } ], "mass": 50524.0, "length": 447, "protein_name": "NAD-dependent histone deacetylase HST3", "gene_name": "HST3", "organism": "Yeast", "refseq_name": "NAD-dependent histone deacetylase HST3", "refseq_ac": [ { "id": "NP_014668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014668", "type": "external" } ], "gene_names_uniprotkb": "HST3; OR26.15", "gene_names_refseq": "HST3", "protein_names_uniprotkb": "NAD-dependent histone deacetylase HST3; 2.3.1.286; Homologous to SIR2 protein 3; Regulatory protein SIR2 homolog 3", "protein_names_refseq": "NAD-dependent histone deacetylase HST3", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR025W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10841563;14562095;14562106;16487579;16815704;17106263;17322287;19795423;19823750;21126336;21725298;23749301;24374639;24648511;32597660;33481703;33491328;7498786;9169874", "class_list": "", "function": "NAD-dependent histone deacetylase, which contributes together with HST4 to histone H3 'Lys-56' deacetylation, regulation of telomeric silencing, proper cell cycle progression, DNA damage control, DNA recombination, and genomic maintenance., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W291;Q66R16", "ec_number_list": [ { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0070403 NAD+ binding;GO:0017136 histone deacetylase activity, NAD-dependent", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006351 DNA-templated transcription;GO:0046459 short-chain fatty acid metabolic process;GO:0000183 rDNA heterochromatin formation;GO:0009299 mRNA transcription", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P53687-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53688-1", "uniprot_id": [ { "id": "HST4_YEAST", "url": "https://www.uniprot.org/uniprot/P53688", "type": "external" } ], "mass": 41765.0, "length": 370, "protein_name": "NAD-dependent histone deacetylase HST4", "gene_name": "HST4", "organism": "Yeast", "refseq_name": "NAD-dependent histone deacetylase HST4", "refseq_ac": [ { "id": "NP_010477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010477", "type": "external" } ], "gene_names_uniprotkb": "HST4; YD9346.03", "gene_names_refseq": "HST4", "protein_names_uniprotkb": "NAD-dependent histone deacetylase HST4; 2.3.1.286; Homologous to SIR2 protein 4; Regulatory protein SIR2 homolog 4", "protein_names_refseq": "NAD-dependent histone deacetylase HST4", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR191W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10841563;14562095;14562106;16487579;16815704;17106263;17322287;24374639;7498786;8810037;9169867", "class_list": "", "function": "NAD-dependent histone deacetylase, which contributes together with HST3 to histone H3 'Lys-56' deacetylation, regulation of telomeric silencing, proper cell cycle progression, DNA damage control, DNA recombination, and genomic maintenance., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VSH4", "ec_number_list": [ { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0070403 NAD+ binding;GO:0017136 histone deacetylase activity, NAD-dependent", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0000781 chromosome, telomeric region;GO:0031934 mating-type region heterochromatin", "go_biological_process": "GO:0031508 pericentric heterochromatin formation;GO:0031509 subtelomeric heterochromatin formation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0046459 short-chain fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53688-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53833-1", "uniprot_id": [ { "id": "POP3_YEAST", "url": "https://www.uniprot.org/uniprot/P53833", "type": "external" } ], "mass": 22612.0, "length": 195, "protein_name": "Ribonucleases P/MRP protein subunit POP3", "gene_name": "POP3", "organism": "Yeast", "refseq_name": "Pop3p", "refseq_ac": [ { "id": "NP_014117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014117", "type": "external" } ], "gene_names_uniprotkb": "POP3; N0586", "gene_names_refseq": "POP3", "protein_names_uniprotkb": "Ribonucleases P/MRP protein subunit POP3; RNA-processing protein POP3; RNases MRP/P 22.6 kDa subunit", "protein_names_refseq": "Pop3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL282W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;14690591;15637077;24374639;9029160;9169873;9620854", "class_list": "", "function": "Required for processing of 5.8S rRNA (short form) at site A3 and for 5'- and 3'-processing of pre-tRNA., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0R2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0000172 ribonuclease MRP complex", "go_biological_process": "GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent;GO:0008033 tRNA processing;GO:0006364 rRNA processing;GO:0000460 maturation of 5.8S rRNA;GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P53833-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53844-1", "uniprot_id": [ { "id": "PDR17_YEAST", "url": "https://www.uniprot.org/uniprot/P53844", "type": "external" } ], "mass": 40678.0, "length": 350, "protein_name": "Phosphatidylinositol transfer protein PDR17", "gene_name": "PDR17", "organism": "Yeast", "refseq_name": "phosphatidylinositol transporter", "refseq_ac": [ { "id": "NP_014135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014135", "type": "external" } ], "gene_names_uniprotkb": "PDR17; ISS1; N0815; PSTB2; SFH4", "gene_names_refseq": "ISS1; PDR17; SFH4", "protein_names_uniprotkb": "Phosphatidylinositol transfer protein PDR17; PITP; Phosphatidylserine transport B pathway protein 2; Pleiotropic drug resistance protein 17; SEC14 homolog 3", "protein_names_refseq": "phosphatidylinositol transporter", "tax_id": 559292, "disease": "Bothnia retinal dystrophy (Disease Ontology:DOID:0050683); Newfoundland cone-rod dystrophy (Disease Ontology:DOID:0111015); retinitis pigmentosa (Disease Ontology:DOID:10584); fundus albipunctatus (Disease Ontology:DOID:11105); night blindness (Disease Ontology:DOID:8499)", "pathway": " (sce:YNL264C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10799527;10848624;12869188;14562095;14562106;17322287;20016005;24366873;24374639;32597660;33481703;33491328;8740425;9169873;9890948", "class_list": "", "function": "Has phosphatidylinositol transfer activity (PubMed:10799527, PubMed:10848624, PubMed:24366873). Involved in the regulation of the phospholipid composition of plasma- and endomembranes (PubMed:9890948). Altering plasma membrane composition may provide a possible mechanism for multidrug resistance (PubMed:9890948). Contributes to efficient phospholipase D1 activation and phospholipase B1 inhibition in the regulation of phospholipid turnover (PubMed:10848624). Forms a complex with phosphatidylserine decarboxylase PSD2 that seems essential for maintenance of vacuolar phosphatidylethanolamine (PE) levels (PubMed:20016005, PubMed:24366873). Allows interorganelle phosphatidylserine (PtdSer) transport via a process that involves the acceptor membrane complex PDR17-PDS2 that binds to PBI1 which in turn ligates to SCS2 and phosphatidic acid present in the donor membrane, forming a zone of apposition that facilitates PtdSer transfer (PubMed:24366873)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0S9", "ec_number_list": [], "go_molecular_function": "GO:0032934 sterol binding;GO:0008526 phosphatidylinositol transfer activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0010008 endosome membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0016126 sterol biosynthetic process;GO:0015914 phospholipid transport;GO:2001247 positive regulation of phosphatidylcholine biosynthetic process;GO:0043001 Golgi to plasma membrane protein transport;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P53844-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53855-1", "uniprot_id": [ { "id": "ATG2_YEAST", "url": "https://www.uniprot.org/uniprot/P53855", "type": "external" } ], "mass": 178414.0, "length": 1592, "protein_name": "Autophagy-related protein 2", "gene_name": "ATG2", "organism": "Yeast", "refseq_name": "Atg2p", "refseq_ac": [ { "id": "NP_014157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014157", "type": "external" } ], "gene_names_uniprotkb": "ATG2; APG2; AUT8; N1106; SPO72", "gene_names_refseq": "APG2; ATG2; AUT8; SPO72", "protein_names_uniprotkb": "Autophagy-related protein 2; Sporulation-specific protein 72", "protein_names_refseq": "Atg2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL242W)", "pathway_count": 1, "publication_count": 36, "publication_id_list": "10029994;11382760;11382761;11675007;14536056;14562106;14723849;17295840;17563356;18407956;18586673;18625846;18829864;19371383;19779198;19995911;20444982;22728243;22851171;23230146;23337777;23549786;23749301;23904270;24374639;24440502;28704456;29848619;30254161;31553916;32809042;33491328;34965436;8224160;8896273;9169873", "class_list": "", "function": "Lipid transfer protein required for autophagosome completion and peroxisome degradation (PubMed:10029994, PubMed:11382760, PubMed:11382761, PubMed:11675007, PubMed:18586673, PubMed:18625846, PubMed:19371383, PubMed:19995911, PubMed:22728243, PubMed:23230146, PubMed:8224160). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:28704456, PubMed:29848619, PubMed:30254161). ATG2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region (PubMed:30254161). The latter binding is assisted by an ATG18-PtdIns3P interaction (PubMed:30254161). ATG2 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion (PubMed:30254161). ATG2 is also involved in the recruitment of lipids to a restricted region close to the vacuole, termed the vacuole-isolation membrane contact site (VICS), which is also essential for autophagosome formation (PubMed:28704456). Necessary for the localization of ATG18 to the preautophagosomal structure (PAS) and the binding of ATG18 to ATG9 (PubMed:14723849, PubMed:18586673, PubMed:18625846, PubMed:19371383, PubMed:23230146). ATG2 is the most downstream ATG protein in the preautophagosomal structure organization process (PubMed:17295840). Involved in correct ATG9 trafficking through the preautophagosomal structure and in peroxisome degradation (PubMed:14723849). Plays a significant role in life span extension (PubMed:23337777)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0V1", "ec_number_list": [], "go_molecular_function": "GO:0043495 protein-membrane adaptor activity;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0120013 lipid transfer activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0016236 macroautophagy;GO:0006914 autophagy;GO:0000422 autophagy of mitochondrion;GO:0044804 nucleophagy", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P53855-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53863-1", "uniprot_id": [ { "id": "JJJ1_YEAST", "url": "https://www.uniprot.org/uniprot/P53863", "type": "external" } ], "mass": 68783.0, "length": 590, "protein_name": "J protein JJJ1", "gene_name": "JJJ1", "organism": "Yeast", "refseq_name": "Jjj1p", "refseq_ac": [ { "id": "NP_014172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014172", "type": "external" } ], "gene_names_uniprotkb": "JJJ1; N1254", "gene_names_refseq": "JJJ1", "protein_names_uniprotkb": "J protein JJJ1", "protein_names_refseq": "Jjj1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL227C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562106;17330950;18407956;19684113;19779198;19795423;19823750;20702584;21126336;22218487;23749301;24374639;30516470;33481703;33491328;8896273;9169873", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0W4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0006897 endocytosis;GO:0042273 ribosomal large subunit biogenesis;GO:0006364 rRNA processing;GO:0008361 regulation of cell size", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P53863-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53867-1", "uniprot_id": [ { "id": "ATG4_YEAST", "url": "https://www.uniprot.org/uniprot/P53867", "type": "external" } ], "mass": 55143.0, "length": 494, "protein_name": "Cysteine protease ATG4", "gene_name": "ATG4", "organism": "Yeast", "refseq_name": "cysteine protease ATG4", "refseq_ac": [ { "id": "NP_014176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014176", "type": "external" } ], "gene_names_uniprotkb": "ATG4; APG4; AUT2; N1274", "gene_names_refseq": "APG4; ATG4; AUT2", "protein_names_uniprotkb": "Cysteine protease ATG4; 3.4.22.-; Autophagy-related protein 4", "protein_names_refseq": "cysteine protease ATG4", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YNL223W); (R-SCE-1632852)", "pathway_count": 2, "publication_count": 33, "publication_id_list": "11038174;11100732;11149920;11904149;12748633;14536056;14562095;14562106;16680092;17632063;18407956;18701704;18725539;19779198;20647741;22240591;22652539;23749301;24374639;25483965;28287329;28330855;28704456;28821724;30510114;32597660;33481703;33491328;8050581;8224160;8896273;9169873;9649430", "class_list": "", "function": "Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8 (PubMed:11038174, PubMed:11100732, PubMed:11149920, PubMed:11904149, PubMed:16680092, PubMed:18701704, PubMed:18725539, PubMed:28330855, PubMed:28704456, PubMed:28821724, PubMed:8050581, PubMed:8224160, PubMed:9649430). Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:11038174, PubMed:11100732, PubMed:11149920, PubMed:11904149, PubMed:16680092, PubMed:18701704, PubMed:18725539, PubMed:8050581, PubMed:8224160, PubMed:9649430). The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine (PubMed:11038174, PubMed:11100732, PubMed:11149920, PubMed:11904149, PubMed:16680092, PubMed:18701704, PubMed:18725539, PubMed:8050581, PubMed:8224160, PubMed:9649430). ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy (PubMed:11038174, PubMed:11100732, PubMed:11149920, PubMed:11904149, PubMed:16680092, PubMed:18701704, PubMed:18725539, PubMed:8050581, PubMed:8224160, PubMed:9649430). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (PubMed:17632063). In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components (PubMed:22240591, PubMed:22652539, PubMed:28330855, PubMed:28704456, PubMed:28821724). ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS (PubMed:22240591, PubMed:22652539)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0W7", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0019786 protein-phosphatidylethanolamide deconjugating activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006508 proteolysis;GO:0016485 protein processing;GO:0006612 protein targeting to membrane;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P53867-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53877-1", "uniprot_id": [ { "id": "IPI3_YEAST", "url": "https://www.uniprot.org/uniprot/P53877", "type": "external" } ], "mass": 61773.0, "length": 555, "protein_name": "Pre-rRNA-processing protein IPI3", "gene_name": "IPI3", "organism": "Yeast", "refseq_name": "chromatin-binding/pre-rRNA-processing protein IPI3", "refseq_ac": [ { "id": "NP_014217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014217", "type": "external" } ], "gene_names_uniprotkb": "IPI3; N1636", "gene_names_refseq": "IPI3", "protein_names_uniprotkb": "Pre-rRNA-processing protein IPI3; Involved in processing IST2 protein 3", "protein_names_refseq": "chromatin-binding/pre-rRNA-processing protein IPI3", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YNL182C); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14690591;14759368;15260980;15528184;18407956;24374639;26619264;33481703;33491328;9169873", "class_list": "", "function": "Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W104", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005656 nuclear pre-replicative complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0120330 rixosome complex", "go_biological_process": "GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication;GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0006364 rRNA processing;GO:0000027 ribosomal large subunit assembly;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P53877-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53886-1", "uniprot_id": [ { "id": "APC1_YEAST", "url": "https://www.uniprot.org/uniprot/P53886", "type": "external" } ], "mass": 196162.0, "length": 1748, "protein_name": "Anaphase-promoting complex subunit 1", "gene_name": "APC1", "organism": "Yeast", "refseq_name": "anaphase promoting complex subunit 1", "refseq_ac": [ { "id": "NP_014227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014227", "type": "external" } ], "gene_names_uniprotkb": "APC1; N1677", "gene_names_refseq": "APC1", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 1", "protein_names_refseq": "anaphase promoting complex subunit 1", "tax_id": 559292, "disease": "Rothmund-Thomson syndrome (Disease Ontology:DOID:2732)", "pathway": " (sce:YNL172W); (R-SCE-983168)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12609981;14562095;14562106;18407956;19779198;23749301;24374639;32597660;33481703;33491328;8895471;9169873", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W112", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle;GO:0016567 protein ubiquitination;GO:0010458 exit from mitosis;GO:0031145 anaphase-promoting complex-dependent catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P53886-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53900-1", "uniprot_id": [ { "id": "PFD4_YEAST", "url": "https://www.uniprot.org/uniprot/P53900", "type": "external" } ], "mass": 15180.0, "length": 129, "protein_name": "Prefoldin subunit 4", "gene_name": "GIM3", "organism": "Yeast", "refseq_name": "tubulin-binding prefolding complex subunit GIM3", "refseq_ac": [ { "id": "NP_014246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014246", "type": "external" } ], "gene_names_uniprotkb": "GIM3; N1761; PFD4", "gene_names_refseq": "GIM3; PFD4", "protein_names_uniprotkb": "Prefoldin subunit 4; Genes involved in microtubule biogenesis protein 3; Gim complex subunit 3; GimC subunit 3", "protein_names_refseq": "tubulin-binding prefolding complex subunit GIM3", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL153C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562106;17322287;22814378;24374639;33481703;8686380;9169873;9463374;9878052", "class_list": "", "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W130", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016272 prefoldin complex", "go_biological_process": "GO:0006457 protein folding;GO:0007021 tubulin complex assembly;GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P53900-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53901-1", "uniprot_id": [ { "id": "INN1_YEAST", "url": "https://www.uniprot.org/uniprot/P53901", "type": "external" } ], "mass": 46226.0, "length": 409, "protein_name": "Ingression protein 1", "gene_name": "INN1", "organism": "Yeast", "refseq_name": "Inn1p", "refseq_ac": [ { "id": "NP_014247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014247", "type": "external" } ], "gene_names_uniprotkb": "INN1; N1765", "gene_names_refseq": "INN1", "protein_names_uniprotkb": "Ingression protein 1", "protein_names_refseq": "Inn1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL152W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "17322287;18344988;18407956;19528296;19707790;19779198;19795423;19823750;20442249;20702584;23749301;24374639;32597660;33229814;33481703;33491328;8686380;9169873", "class_list": "", "function": "Required for the ingression of the plasma membrane into the bud neck at the end of cytokinesis, leading to the separation of the mother and daughter cells. Stimulates the synthesis of the primary septum (PS) by CHS2., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6W131;Q6Q5J6", "ec_number_list": [], "go_molecular_function": "GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0032154 cleavage furrow;GO:0044697 HICS complex;GO:0000142 cellular bud neck contractile ring", "go_biological_process": "GO:0000281 mitotic cytokinesis;GO:0051276 chromosome organization;GO:1902410 mitotic cytokinetic process;GO:1990344 secondary cell septum biogenesis", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P53901-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53909-1", "uniprot_id": [ { "id": "ADE_YEAST", "url": "https://www.uniprot.org/uniprot/P53909", "type": "external" } ], "mass": 39635.0, "length": 347, "protein_name": "Adenine deaminase", "gene_name": "AAH1", "organism": "Yeast", "refseq_name": "adenine deaminase", "refseq_ac": [ { "id": "NP_014258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014258", "type": "external" } ], "gene_names_uniprotkb": "AAH1; N1208; N1825", "gene_names_refseq": "AAH1", "protein_names_uniprotkb": "Adenine deaminase; 3.5.4.2; AAH; ADE; Adenine aminohydrolase", "protein_names_refseq": "adenine deaminase", "tax_id": 559292, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); trypanosomiasis (Disease Ontology:DOID:10113); Legionnaires' disease (Disease Ontology:DOID:10457); stomach cancer (Disease Ontology:DOID:10534); pleural tuberculosis (Disease Ontology:DOID:106); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); Q fever (Disease Ontology:DOID:11100); pulmonary edema (Disease Ontology:DOID:11396); familial hyperlipidemia (Disease Ontology:DOID:1168); uterine fibroid (Disease Ontology:DOID:13223); Mycoplasma pneumoniae pneumonia (Disease Ontology:DOID:13276); pulmonary sarcoidosis (Disease Ontology:DOID:13406); sporotrichosis (Disease Ontology:DOID:14484); malignant mesothelioma (Disease Ontology:DOID:1790); colon cancer (Disease Ontology:DOID:219); leptospirosis (Disease Ontology:DOID:2297); asthma (Disease Ontology:DOID:2841); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); pulmonary tuberculosis (Disease Ontology:DOID:2957); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); adenosine deaminase deficiency (Disease Ontology:DOID:5810); severe combined immunodeficiency (Disease Ontology:DOID:627); peritonitis (Disease Ontology:DOID:8283); lung disease (Disease Ontology:DOID:850); oral cavity cancer (Disease Ontology:DOID:8618); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YNL141W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;14562106;14643670;1577682;17517885;18673302;24374639;33481703;33491328;8619318;9169873", "class_list": "", "function": "Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. Also exhibits a low activity towards N(6)-substituted adenines that are commonly known as the plant hormones cytokinins., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W141", "ec_number_list": [ { "id": "3.5.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.2", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000034 adenine deaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0009117 nucleotide metabolic process;GO:0043101 purine-containing compound salvage;GO:0009168 purine ribonucleoside monophosphate biosynthetic process;GO:0043103 hypoxanthine salvage;GO:0006146 adenine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53909-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53923-1", "uniprot_id": [ { "id": "CTU2_YEAST", "url": "https://www.uniprot.org/uniprot/P53923", "type": "external" } ], "mass": 56473.0, "length": 493, "protein_name": "Cytoplasmic tRNA 2-thiolation protein 2", "gene_name": "NCS2", "organism": "Yeast", "refseq_name": "Ncs2p", "refseq_ac": [ { "id": "NP_014280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014280", "type": "external" } ], "gene_names_uniprotkb": "NCS2; CTU2; N1913; TUC2", "gene_names_refseq": "NCS2; TUC2", "protein_names_uniprotkb": "Cytoplasmic tRNA 2-thiolation protein 2; Needs CLA4 to survive protein 2; Thiolation of uridine in cytoplasmic tRNA protein 2", "protein_names_refseq": "Ncs2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL119W)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "14551258;14562095;14562106;14671320;17322287;17330950;18407956;18664566;18755837;18780730;19145231;19151091;19684113;19779198;19795423;19823750;21126336;23749301;24374639;32597660;33481703;33491328;9169873", "class_list": "", "function": "Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation and in invasive and pseudohyphal growth. Inhibits replication of Brome mosaic virus., [UniProtKB, PubMed, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0KZR6;B0KZS5;B0KZU3;B0KZW1;B0L006;D6W163;Q66R25", "ec_number_list": [], "go_molecular_function": "GO:0016783 sulfurtransferase activity;GO:0000049 tRNA binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation;GO:0034227 tRNA thio-modification;GO:0002098 tRNA wobble uridine modification;GO:0032447 protein urmylation;GO:0001403 invasive growth in response to glucose limitation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P53923-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53927-1", "uniprot_id": [ { "id": "NOP15_YEAST", "url": "https://www.uniprot.org/uniprot/P53927", "type": "external" } ], "mass": 25447.0, "length": 220, "protein_name": "Ribosome biogenesis protein 15", "gene_name": "NOP15", "organism": "Yeast", "refseq_name": "rRNA-binding ribosome biosynthesis protein NOP15", "refseq_ac": [ { "id": "NP_014289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014289", "type": "external" } ], "gene_names_uniprotkb": "NOP15; N1954", "gene_names_refseq": "NOP15", "protein_names_uniprotkb": "Ribosome biogenesis protein 15; Nucleolar protein 15", "protein_names_refseq": "rRNA-binding ribosome biosynthesis protein NOP15", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL110C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10953080;11583614;14562106;14657029;15100437;17322287;19795423;19823750;22218487;24374639;33481703;33491328;9169873", "class_list": "", "function": "Involved in the biogenesis of the 60S ribosomal subunit. Required for pre-rRNA processing and cytokinesis. Associates with the precursors of the 25S and 5.8S rRNAs., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W171", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0019843 rRNA binding;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0006364 rRNA processing;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P53927-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53951-1", "uniprot_id": [ { "id": "COG5_YEAST", "url": "https://www.uniprot.org/uniprot/P53951", "type": "external" } ], "mass": 45604.0, "length": 403, "protein_name": "Conserved oligomeric Golgi complex subunit 5", "gene_name": "COG5", "organism": "Yeast", "refseq_name": "Golgi transport complex subunit COG5", "refseq_ac": [ { "id": "NP_014347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014347", "type": "external" } ], "gene_names_uniprotkb": "COG5; COD4; N2476; YNL2476W", "gene_names_refseq": "API4; COD4; COG5", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 5; COG complex subunit 5; Complexed with DOR1 protein 4; Component of oligomeric Golgi complex 5", "protein_names_refseq": "Golgi transport complex subunit COG5", "tax_id": 559292, "disease": "congenital disorder of glycosylation type IIi (Disease Ontology:DOID:0070261)", "pathway": " (sce:YNL051W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11703943;14562106;15047703;24374639;33491328;8533472;9169873", "class_list": "", "function": "Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1C8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0000301 retrograde transport, vesicle recycling within Golgi;GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P53951-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53955-1", "uniprot_id": [ { "id": "SLM2_YEAST", "url": "https://www.uniprot.org/uniprot/P53955", "type": "external" } ], "mass": 74785.0, "length": 656, "protein_name": "Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2", "gene_name": "SLM2", "organism": "Yeast", "refseq_name": "phosphatidylinositol 4,5-bisphosphate-binding protein", "refseq_ac": [ { "id": "NP_014351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014351", "type": "external" } ], "gene_names_uniprotkb": "SLM2; LIT1; N2515; YNL2515P", "gene_names_refseq": "LIT1; SLM2", "protein_names_uniprotkb": "Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2; Synthetic lethal with MSS4 protein 2; TORC2 effector protein SLM2", "protein_names_refseq": "phosphatidylinositol 4,5-bisphosphate-binding protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL047C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "14562106;15023338;15372071;15689497;16012843;16738335;17322287;17330950;18407956;19779198;20702584;23749301;24374639;32597660;33229814;33481703;33491328;34965436;8533472;8740423;9169873", "class_list": "", "function": "Together with SLM1, effector of the TORC2- and calcineurin-signaling pathways. Phosphorylated and activated by TORC2 under favorable growth conditions. Mediates actin polarization via inhibition of calcineurin-dependent transcription. Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin, inhibiting interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization. Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W1D2;Q2VQW4", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0030036 actin cytoskeleton organization;GO:0051017 actin filament bundle assembly;GO:0001558 regulation of cell growth;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P53955-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53959-1", "uniprot_id": [ { "id": "COG6_YEAST", "url": "https://www.uniprot.org/uniprot/P53959", "type": "external" } ], "mass": 96976.0, "length": 839, "protein_name": "Conserved oligomeric Golgi complex subunit 6", "gene_name": "COG6", "organism": "Yeast", "refseq_name": "Golgi transport complex subunit COG6", "refseq_ac": [ { "id": "NP_014357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014357", "type": "external" } ], "gene_names_uniprotkb": "COG6; COD2; N2675; SEC37; TFI2", "gene_names_refseq": "COD2; COG6; SEC37", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 6; COG complex subunit 6; Complexed with DOR1 protein 2; Component of oligomeric Golgi complex 6; Protein SEC37", "protein_names_refseq": "Golgi transport complex subunit COG6", "tax_id": 559292, "disease": "congenital disorder of glycosylation type IIl (Disease Ontology:DOID:0070264)", "pathway": " (sce:YNL041C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11703943;12006647;12011112;14562106;15047703;23749301;24374639;32597660;33481703;33491328;9169873", "class_list": "", "function": "Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1D8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0000301 retrograde transport, vesicle recycling within Golgi;GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53959-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54005-1", "uniprot_id": [ { "id": "DIA1_YEAST", "url": "https://www.uniprot.org/uniprot/P54005", "type": "external" } ], "mass": 38760.0, "length": 336, "protein_name": "Protein DIA1", "gene_name": "DIA1", "organism": "Yeast", "refseq_name": "Dia1p", "refseq_ac": [ { "id": "NP_014047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014047", "type": "external" } ], "gene_names_uniprotkb": "DIA1; YM9924.08", "gene_names_refseq": "DIA1", "protein_names_uniprotkb": "Protein DIA1; Digs into agar protein 1", "protein_names_refseq": "Dia1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR316W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11063681;14562095;14562106;24374639;9169872", "class_list": "", "function": "Involved in regulation of invasive growth., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0E4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0001403 invasive growth in response to glucose limitation;GO:0007124 pseudohyphal growth", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P54005-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54791-1", "uniprot_id": [ { "id": "ORC4_YEAST", "url": "https://www.uniprot.org/uniprot/P54791", "type": "external" } ], "mass": 60705.0, "length": 529, "protein_name": "Origin recognition complex subunit 4", "gene_name": "ORC4", "organism": "Yeast", "refseq_name": "origin recognition complex subunit 4", "refseq_ac": [ { "id": "NP_015488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015488", "type": "external" } ], "gene_names_uniprotkb": "ORC4; P9325.5", "gene_names_refseq": "ORC4", "protein_names_uniprotkb": "Origin recognition complex subunit 4; Origin recognition complex 56 kDa subunit", "protein_names_refseq": "origin recognition complex subunit 4", "tax_id": 559292, "disease": "Meier-Gorlin syndrome (Disease Ontology:DOID:0060306); Meier-Gorlin syndrome 2 (Disease Ontology:DOID:0080513)", "pathway": " (sce:YPR162C); (R-SCE-176187); (R-SCE-68616); (R-SCE-68689); (R-SCE-68962)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "14562106;17322287;18407956;19779198;19795423;19823750;21126336;23749301;24374639;32597660;33481703;33491328;7585959;9169875", "class_list": "", "function": "Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4G3", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding", "go_cellular_component": "GO:0005656 nuclear pre-replicative complex;GO:0031261 DNA replication preinitiation complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005664 nuclear origin of replication recognition complex", "go_biological_process": "GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication;GO:0006270 DNA replication initiation;GO:0030466 silent mating-type cassette heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P54791-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57743-1", "uniprot_id": [ { "id": "LSM3_YEAST", "url": "https://www.uniprot.org/uniprot/P57743", "type": "external" } ], "mass": 10030.0, "length": 89, "protein_name": "LSM complex subunit LSM3", "gene_name": "LSM3", "organism": "Yeast", "refseq_name": "U4/U6-U5 snRNP complex subunit LSM3", "refseq_ac": [ { "id": "NP_013543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013543", "type": "external" } ], "gene_names_uniprotkb": "LSM3; SMX4; USS2", "gene_names_refseq": "LSM3; SMX4; USS2", "protein_names_uniprotkb": "LSM complex subunit LSM3; SmX4 protein", "protein_names_refseq": "U4/U6-U5 snRNP complex subunit LSM3", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR438C-A); (R-SCE-430039)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "10369684;10428970;10449419;10747033;10761922;12077351;12438310;14562095;14562106;15075370;15485930;18329667;22814378;24139796;24240276;24247251;24374639;24513854;2824201;29717126;30059503;33491328;7744014;7828914;9169871", "class_list": "", "function": "Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner (PubMed:10747033, PubMed:12077351, PubMed:12438310, PubMed:24513854, PubMed:24247251). Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step (PubMed:10747033, PubMed:10761922, PubMed:24513854, PubMed:24247251). Together with PAT1, the LSM1-LSM7 complex binds to osmotic stress-activated mRNAs to attenuate the osmotic stress response, probably by limiting ribosome access to the mRNA and consequently translation (PubMed:30059503). Component of the nuclear LSM2-LSM8 complex, which is involved in spliceosome assembly (PubMed:7744014, PubMed:10747033, PubMed:12077351, PubMed:12438310). The LSM2-LSM8 complex plays a role in the biogenesis of the spliceosomal U4/U6-U5 tri-snRNP complex by accelerating PRP24-mediated annealing of U4/U6 di-snRNA (PubMed:10747033, PubMed:24240276, PubMed:29717126). The LSM2-LSM8 complex binds U6 snRNA terminating with a non-cyclic 3' phosphate group (PubMed:29717126). LSM2-LSM8 is probably also involved in degradation of nuclear pre-mRNA by targeting them for decapping (PubMed:15485930). LSM2-LSM8 could be involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA, although involvement may be indirect (PubMed:12077351, PubMed:12438310, PubMed:15075370). In a complex that probably contains LSM2-LSM7, but not LSM1 or LSM8, associates with the precursor of the RNA component of RNase P (pre-P RNA) and may be involved in maturing pre-P RNA; the complex also associates with snoRNA SNR5 (PubMed:10369684, PubMed:15075370)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ73;Q05176;Q06759", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0008033 tRNA processing;GO:0000398 mRNA splicing, via spliceosome;GO:0006364 rRNA processing;GO:0033962 P-body assembly", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P57743-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57744-1", "uniprot_id": [ { "id": "TIM8_YEAST", "url": "https://www.uniprot.org/uniprot/P57744", "type": "external" } ], "mass": 9764.0, "length": 87, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM8", "gene_name": "TIM8", "organism": "Yeast", "refseq_name": "protein transporter TIM8", "refseq_ac": [ { "id": "NP_058168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058168", "type": "external" } ], "gene_names_uniprotkb": "TIM8; YJR135BW", "gene_names_refseq": "TIM8", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM8", "protein_names_refseq": "protein transporter TIM8", "tax_id": 559292, "disease": "deafness-dystonia-optic neuronopathy syndrome (Disease Ontology:DOID:0050757); dystonia (Disease Ontology:DOID:543)", "pathway": " (sce:YJR135W-A)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10397776;10469659;10995434;11101512;11509656;12221072;16823961;17322287;21126336;22984289;24374639;33491328;8641269", "class_list": "", "function": "Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins under precise conditions, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins. Strictly required for import of TIM23 in some conditions, when a low membrane potential exists in the mitochondria., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWV4", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0042719 mitochondrial intermembrane space chaperone complex;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0015031 protein transport;GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P57744-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P69771-1", "uniprot_id": [ { "id": "DID2_YEAST", "url": "https://www.uniprot.org/uniprot/P69771", "type": "external" } ], "mass": 23091.0, "length": 204, "protein_name": "Vacuolar protein-sorting-associated protein 46", "gene_name": "DID2", "organism": "Yeast", "refseq_name": "Did2p", "refseq_ac": [ { "id": "NP_012961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012961", "type": "external" } ], "gene_names_uniprotkb": "DID2; CHM1; FTI1; VPS46", "gene_names_refseq": "CHM1; DID2; FTI1; VPL30; VPS46", "protein_names_uniprotkb": "Vacuolar protein-sorting-associated protein 46; Charged multivesicular body protein 1; DOA4-independent degradation protein 2; Fifty two inhibitor 1", "protein_names_refseq": "Did2p", "tax_id": 559292, "disease": "pontocerebellar hypoplasia type 8 (Disease Ontology:DOID:0060277)", "pathway": " (sce:YKR035W-A)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11029042;11559748;14562095;14562106;15086794;16601096;17130288;17928861;18032584;18194652;19779198;24374639;33481703;33491328;8196765", "class_list": "", "function": "Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole. Probably acts as a peripherally associated component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruits late-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. Regulates the membrane association of VPS4. Can stimulate VPS4 ATPase activity directly or via VTA1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX98", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005737 cytoplasm;GO:0005770 late endosome;GO:0005771 multivesicular body", "go_biological_process": "GO:0015031 protein transport;GO:0045324 late endosome to vacuole transport;GO:0032509 endosome transport via multivesicular body sorting pathway;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway;GO:1904902 ESCRT III complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P69771-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00453-1", "uniprot_id": [ { "id": "RGM1_YEAST", "url": "https://www.uniprot.org/uniprot/Q00453", "type": "external" } ], "mass": 23855.0, "length": 211, "protein_name": "Probable transcription repressor protein RGM1", "gene_name": "RGM1", "organism": "Yeast", "refseq_name": "Rgm1p", "refseq_ac": [ { "id": "NP_013907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013907", "type": "external" } ], "gene_names_uniprotkb": "RGM1; YM8010.12C", "gene_names_refseq": "RGM1", "protein_names_uniprotkb": "Probable transcription repressor protein RGM1", "protein_names_refseq": "Rgm1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR182C)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14562106;1923755;24374639;9169872", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W005", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q00453-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02205-1", "uniprot_id": [ { "id": "MEH1_YEAST", "url": "https://www.uniprot.org/uniprot/Q02205", "type": "external" } ], "mass": 20242.0, "length": 184, "protein_name": "Protein MEH1", "gene_name": "MEH1", "organism": "Yeast", "refseq_name": "Meh1p", "refseq_ac": [ { "id": "NP_012932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012932", "type": "external" } ], "gene_names_uniprotkb": "MEH1; EGO1; GSE2; YK106", "gene_names_refseq": "EGO1; GSE2; MEH1", "protein_names_uniprotkb": "Protein MEH1; EGO complex subunit 1; GSE complex subunit 2", "protein_names_refseq": "Meh1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR007W)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "1441752;14562106;15665377;15989961;16732272;16751107;17330950;17563356;18407956;19779198;20702584;21126336;21177495;23749301;24374639;27821475;29698392;30516470;32597660;32801125;33481703;33491328;8196765", "class_list": "", "function": "Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome (PubMed:16732272). Component of the EGO complex, a complex involved in the regulation of microautophagy (PubMed:15989961)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX73", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0045121 membrane raft;GO:0031902 late endosome membrane;GO:0005770 late endosome;GO:0071986 Ragulator complex", "go_biological_process": "GO:0015031 protein transport;GO:0043410 positive regulation of MAPK cascade;GO:0001919 regulation of receptor recycling;GO:0032008 positive regulation of TOR signaling;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q02205-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02256-1", "uniprot_id": [ { "id": "PVH1_YEAST", "url": "https://www.uniprot.org/uniprot/Q02256", "type": "external" } ], "mass": 41185.0, "length": 364, "protein_name": "Tyrosine-protein phosphatase YVH1", "gene_name": "YVH1", "organism": "Yeast", "refseq_name": "tyrosine protein phosphatase YVH1", "refseq_ac": [ { "id": "NP_012292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012292", "type": "external" } ], "gene_names_uniprotkb": "YVH1", "gene_names_refseq": "YVH1", "protein_names_uniprotkb": "Tyrosine-protein phosphatase YVH1; 3.1.3.48; PTPase YVH1", "protein_names_refseq": "tyrosine protein phosphatase YVH1", "tax_id": 559292, "disease": "", "pathway": " (sce:YIR026C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "1334559;14562106;1803816;18407956;21126336;22814378;23749301;24374639;33481703;33491328;8438236;9169870", "class_list": "", "function": "May be directly involved in signal transduction and/or cell cycle regulation. It is necessary for maintaining growth rate or spore germination. Could show both activity toward tyrosine-protein phosphate as well as with serine-protein phosphate., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVV7", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" } ], "go_molecular_function": "GO:1990275 preribosome binding;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0006995 cellular response to nitrogen starvation;GO:0051321 meiotic cell cycle;GO:2000786 positive regulation of autophagosome assembly;GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q02256-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02574-1", "uniprot_id": [ { "id": "MEC3_YEAST", "url": "https://www.uniprot.org/uniprot/Q02574", "type": "external" } ], "mass": 53146.0, "length": 474, "protein_name": "DNA damage checkpoint control protein MEC3", "gene_name": "MEC3", "organism": "Yeast", "refseq_name": "Mec3p", "refseq_ac": [ { "id": "NP_013391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013391", "type": "external" } ], "gene_names_uniprotkb": "MEC3; L8003.15; PIP3; PSO9", "gene_names_refseq": "MEC3; PIP3; PSO9", "protein_names_uniprotkb": "DNA damage checkpoint control protein MEC3", "protein_names_refseq": "Mec3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR288C); (R-SCE-176187)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "12271137;12604797;12672803;14562106;15014082;16137930;16169844;16202664;17563356;18407956;23749301;24374639;32597660;33481703;33491328;7491494;9169871;9670034;9891048;9988274", "class_list": "", "function": "Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. Associates with sites of DNA damage and modulates the MEC1 signaling pathway and the activation of RAD53 in response to DNA damage at phase G1. The complex also physically regulates DNA polymerase zeta-dependent mutagenesis by controlling the access of polymerase zeta to damaged DNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYT4;P87260;Q05887", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035861 site of double-strand break;GO:0030896 checkpoint clamp complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0000723 telomere maintenance;GO:0000724 double-strand break repair via homologous recombination;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:0000077 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q02574-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02629-1", "uniprot_id": [ { "id": "NU100_YEAST", "url": "https://www.uniprot.org/uniprot/Q02629", "type": "external" } ], "mass": 99988.0, "length": 959, "protein_name": "Nucleoporin NUP100/NSP100", "gene_name": "NUP100", "organism": "Yeast", "refseq_name": "FG-nucleoporin NUP100", "refseq_ac": [ { "id": "NP_012855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012855", "type": "external" } ], "gene_names_uniprotkb": "NUP100; NSP100; YKL336", "gene_names_refseq": "NSP100; NUP100", "protein_names_uniprotkb": "Nucleoporin NUP100/NSP100; Nuclear pore protein NUP100/NSP100", "protein_names_refseq": "FG-nucleoporin NUP100", "tax_id": 559292, "disease": "T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (sce:YKL068W)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10684247;11104765;11387327;12372823;12543930;12604785;12791264;12917401;1385442;14562106;15039779;17330950;18407956;19779198;19795423;19823750;21177495;22218487;23749301;24374639;32597660;33481703;33491328;8044840;8091863;8196765;8557738", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP100 plays an important role in several nuclear export and import pathways including poly(A)+ RNA and protein transport., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXL9", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0017056 structural constituent of nuclear pore;GO:0008139 nuclear localization sequence binding;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0044614 nuclear pore cytoplasmic filaments;GO:0044613 nuclear pore central transport channel", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0045893 positive regulation of DNA-templated transcription;GO:0031990 mRNA export from nucleus in response to heat stress;GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q02629-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02630-1", "uniprot_id": [ { "id": "NU116_YEAST", "url": "https://www.uniprot.org/uniprot/Q02630", "type": "external" } ], "mass": 116234.0, "length": 1113, "protein_name": "Nucleoporin NUP116/NSP116", "gene_name": "NUP116", "organism": "Yeast", "refseq_name": "FG-nucleoporin NUP116", "refseq_ac": [ { "id": "NP_013762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013762", "type": "external" } ], "gene_names_uniprotkb": "NUP116; NSP116; YM9532.12C", "gene_names_refseq": "NSP116; NUP116", "protein_names_uniprotkb": "Nucleoporin NUP116/NSP116; Nuclear pore protein NUP116/NSP116", "protein_names_refseq": "FG-nucleoporin NUP116", "tax_id": 559292, "disease": "T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (sce:YMR047C)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10684247;10801828;10891509;10952996;11071906;11104765;11387327;11689687;12372823;12604785;12791264;1385442;1464327;15039779;17203074;19779198;23185031;24374639;32597660;33229814;33481703;33491328;8044840;8524308;9169872;9463388;9891088", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). Plays an important role in several nuclear export and import pathways including poly(A)+ RNA, tRNA, pre-ribosome, and protein transport. By binding ATPase AFG2, promotes AFG2-mediated release of shuttling protein RLP24 from pre-60S ribosomal particles (PubMed:23185031)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VZM2", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0051117 ATPase binding;GO:0017056 structural constituent of nuclear pore;GO:0008139 nuclear localization sequence binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0044614 nuclear pore cytoplasmic filaments;GO:0044613 nuclear pore central transport channel", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0000055 ribosomal large subunit export from nucleus;GO:0006999 nuclear pore organization;GO:0006406 mRNA export from nucleus;GO:0006409 tRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q02630-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02642-1", "uniprot_id": [ { "id": "NACB1_YEAST", "url": "https://www.uniprot.org/uniprot/Q02642", "type": "external" } ], "mass": 17020.0, "length": 157, "protein_name": "Nascent polypeptide-associated complex subunit beta-1", "gene_name": "EGD1", "organism": "Yeast", "refseq_name": "Egd1p", "refseq_ac": [ { "id": "NP_015288", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015288", "type": "external" } ], "gene_names_uniprotkb": "EGD1", "gene_names_refseq": "EGD1", "protein_names_uniprotkb": "Nascent polypeptide-associated complex subunit beta-1; BTF3 homolog EGD1; Beta-1-NAC; GAL4 DNA-binding enhancer protein 1; NAC-beta-1", "protein_names_refseq": "Egd1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL037C)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10219998;10512867;11683391;1448098;14562095;14562106;16926149;17322287;17330950;17563356;18407956;19779198;19795423;19823750;21126336;21177495;22814378;24374639;24909858;27821475;2904437;32597660;33481703;33491328;8052529;9169875", "class_list": "", "function": "Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II. Can enhance DNA binding of the GAL4 protein activator., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3X7;Q02107", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005854 nascent polypeptide-associated complex", "go_biological_process": "GO:0051083 'de novo' cotranslational protein folding;GO:0006351 DNA-templated transcription;GO:0015031 protein transport;GO:0016236 macroautophagy;GO:0006613 cotranslational protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q02642-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02725-1", "uniprot_id": [ { "id": "VTC3_YEAST", "url": "https://www.uniprot.org/uniprot/Q02725", "type": "external" } ], "mass": 96553.0, "length": 835, "protein_name": "Vacuolar transporter chaperone 3 complex subunit 3", "gene_name": "VTC3", "organism": "Yeast", "refseq_name": "vacuolar transporter chaperone", "refseq_ac": [ { "id": "NP_015306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015306", "type": "external" } ], "gene_names_uniprotkb": "VTC3; PHM2", "gene_names_refseq": "PHM2; VTC3", "protein_names_uniprotkb": "Vacuolar transporter chaperone 3 complex subunit 3; Phosphate metabolism protein 2; PolyP polymerase; SPX-dependent polyphosphate polymerase VTC subunit 3; Vacuolar membrane polyphosphate polymerase accessory subunit 3", "protein_names_refseq": "vacuolar transporter chaperone", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL019C)", "pathway_count": 1, "publication_count": 32, "publication_id_list": "10480897;11102525;11823419;12584253;14562106;16847258;17079729;17287358;17330950;17563356;18407956;19390046;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;25315834;27080106;27587415;27821475;28186404;30516470;32597660;33481703;33491328;9169875", "class_list": "", "function": "Accessory subunit of the vacuolar transporter chaperone (VTC) complex. The VTC complex acts as a vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP. VTC exposes its catalytic domain VTC4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation (PubMed:19390046). The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen (PubMed:19390046, PubMed:25315834). PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase (PubMed:25315834). The VTC complex also plays a role in vacuolar membrane fusion (PubMed:11102525, PubMed:11823419). Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation (PubMed:11823419). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules. Inositol polyphosphate binding promotes vacuolar polyphosphate synthesis (PubMed:27080106)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 39, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3Z3", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0000822 inositol hexakisphosphate binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005783 endoplasmic reticulum;GO:0005938 cell cortex;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007034 vacuolar transport;GO:0042144 vacuole fusion, non-autophagic;GO:0061736 engulfment of target by autophagosome;GO:0006797 polyphosphate metabolic process;GO:0030643 intracellular phosphate ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q02725-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02732-1", "uniprot_id": [ { "id": "CENPP_YEAST", "url": "https://www.uniprot.org/uniprot/Q02732", "type": "external" } ], "mass": 42782.0, "length": 369, "protein_name": "Inner kinetochore subunit CTF19", "gene_name": "CTF19", "organism": "Yeast", "refseq_name": "Ctf19p", "refseq_ac": [ { "id": "NP_015307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015307", "type": "external" } ], "gene_names_uniprotkb": "CTF19; LPB13W; MCM18", "gene_names_refseq": "CTF19; MCM18", "protein_names_uniprotkb": "Inner kinetochore subunit CTF19; CENP-P homolog; Chromosome transmission fidelity protein 19; Constitutive centromere-associated network protein CTF19; Minichromosome maintenance protein 18", "protein_names_refseq": "Ctf19p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL018W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10189365;10323865;10958698;11782448;12408861;12589047;14562106;14633972;14690591;22561346;24374639;29046335;33481703;33491328;9169875", "class_list": "", "function": "Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3Z4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore;GO:0000817 COMA complex", "go_biological_process": "GO:0071459 protein localization to chromosome, centromeric region;GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q02732-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02792-1", "uniprot_id": [ { "id": "XRN2_YEAST", "url": "https://www.uniprot.org/uniprot/Q02792", "type": "external" } ], "mass": 115934.0, "length": 1006, "protein_name": "5'-3' exoribonuclease 2", "gene_name": "RAT1", "organism": "Yeast", "refseq_name": "ssRNA exonuclease RAT1", "refseq_ac": [ { "id": "NP_014691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014691", "type": "external" } ], "gene_names_uniprotkb": "RAT1; HKE1; TAP1", "gene_names_refseq": "HKE1; RAT1; TAP1; XRN2", "protein_names_uniprotkb": "5'-3' exoribonuclease 2; 3.1.13.-; Ribonucleic acid-trafficking protein 1; p116", "protein_names_refseq": "ssRNA exonuclease RAT1", "tax_id": 559292, "disease": "adenoid cystic carcinoma (Disease Ontology:DOID:0080202); lung cancer (Disease Ontology:DOID:1324); status epilepticus (Disease Ontology:DOID:1824); leiomyosarcoma (Disease Ontology:DOID:1967)", "pathway": " (sce:YOR048C)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "10805743;11030620;11142370;11238889;12612077;12769851;14561886;14562106;15565157;16131592;1628825;16598041;19779198;23749301;24374639;32597660;33481703;33491328;7608167;8417335;8497260;8497275;9169874;9207242;9315672;9384595;9488433;9584178;9891049", "class_list": "", "function": "Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA, rRNA and small nucleolar RNA (snoRNA) precursors. May promote termination of transcription by RNA polymerase II via the recruitment of 3'-end processing factors to the poly(A) site and by the degradation of nascent RNA downstream of the poly(A) site., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W2B4", "ec_number_list": [ { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019843 rRNA binding;GO:0004534 5'-3' RNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0000398 mRNA splicing, via spliceosome;GO:0006364 rRNA processing;GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q02792-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02805-1", "uniprot_id": [ { "id": "ROD1_YEAST", "url": "https://www.uniprot.org/uniprot/Q02805", "type": "external" } ], "mass": 92349.0, "length": 837, "protein_name": "Protein ROD1", "gene_name": "ROD1", "organism": "Yeast", "refseq_name": "Rod1p", "refseq_ac": [ { "id": "NP_014661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014661", "type": "external" } ], "gene_names_uniprotkb": "ROD1; OR26.08", "gene_names_refseq": "ART4; ROD1", "protein_names_uniprotkb": "Protein ROD1; Resistance to o-dinitrobenzene protein 1", "protein_names_refseq": "Rod1p", "tax_id": 559292, "disease": "stomach cancer (Disease Ontology:DOID:10534); Reye syndrome (Disease Ontology:DOID:14525); glaucoma (Disease Ontology:DOID:1686); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YOR018W)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "12163175;14562106;15665377;17330950;17563356;17949685;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22106047;22218487;23749301;24374639;26920760;28270554;30516470;30610170;32597660;33229814;33481703;33491328;8621680;9169874", "class_list": "", "function": "Mediates resistance to o-dinitrobenzene, calcium and zinc., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 58, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6W284;Q12475", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0071333 cellular response to glucose stimulus;GO:0002092 positive regulation of receptor internalization;GO:0009410 response to xenobiotic stimulus;GO:0070086 ubiquitin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q02805-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02931-1", "uniprot_id": [ { "id": "UTP17_YEAST", "url": "https://www.uniprot.org/uniprot/Q02931", "type": "external" } ], "mass": 101237.0, "length": 896, "protein_name": "NET1-associated nuclear protein 1", "gene_name": "NAN1", "organism": "Yeast", "refseq_name": "Nan1p", "refseq_ac": [ { "id": "NP_015199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015199", "type": "external" } ], "gene_names_uniprotkb": "NAN1; UTP17", "gene_names_refseq": "NAN1; UTP17", "protein_names_uniprotkb": "NET1-associated nuclear protein 1; U three protein 17; U3 protein 17 required for transcription; U3 small nucleolar RNA-associated protein 17; U3 snoRNA-associated protein 17; t-17", "protein_names_refseq": "Nan1p", "tax_id": 559292, "disease": "lissencephaly (Disease Ontology:DOID:0050453); autism spectrum disorder (Disease Ontology:DOID:0060041); subcortical band heterotopia (Disease Ontology:DOID:0111169)", "pathway": " (sce:YPL126W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12068309;14562106;15489292;18407956;23749301;24374639;32597660;33481703;33491328;9169875", "class_list": "", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3P1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0034511 U3 snoRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005777 peroxisome;GO:0033553 rDNA heterochromatin;GO:0034455 t-UTP complex", "go_biological_process": "GO:2000234 positive regulation of rRNA processing;GO:0006351 DNA-templated transcription;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q02931-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02948-1", "uniprot_id": [ { "id": "BECN1_YEAST", "url": "https://www.uniprot.org/uniprot/Q02948", "type": "external" } ], "mass": 63261.0, "length": 557, "protein_name": "Vacuolar protein sorting-associated protein 30", "gene_name": "VPS30", "organism": "Yeast", "refseq_name": "beclin 1", "refseq_ac": [ { "id": "NP_015205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015205", "type": "external" } ], "gene_names_uniprotkb": "VPS30; APG6; ATG6; LPH7; VPT30", "gene_names_refseq": "APG6; ATG6; VPS30; VPT30", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 30; Autophagy-related protein 6", "protein_names_refseq": "beclin 1", "tax_id": 559292, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); polycystic kidney disease (Disease Ontology:DOID:0080322); Parkinsonism (Disease Ontology:DOID:0080855); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); anterior ischemic optic neuropathy (Disease Ontology:DOID:12010); Machado-Joseph disease (Disease Ontology:DOID:1440); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); glioblastoma (Disease Ontology:DOID:3068); ischemia (Disease Ontology:DOID:326); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); esophagus adenocarcinoma (Disease Ontology:DOID:4914); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); paraplegia (Disease Ontology:DOID:607); viral encephalitis (Disease Ontology:DOID:646); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); peritonitis (Disease Ontology:DOID:8283); osteoarthritis (Disease Ontology:DOID:8398); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); diabetic retinopathy (Disease Ontology:DOID:8947); degenerative disc disease (Disease Ontology:DOID:90); Barrett's esophagus (Disease Ontology:DOID:9206); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (sce:YPL120W); (R-SCE-1632852)", "pathway_count": 2, "publication_count": 33, "publication_id_list": "11157979;11689437;12244127;14562095;14562106;16267277;16421251;17295840;17404498;17700056;18182384;18407956;18701704;19001347;19131141;19779198;20489023;21126336;22437838;23549786;23749301;23878393;24165940;24374639;26450213;32597660;33481703;33491328;34965436;8224160;9105038;9169875;9712845", "class_list": "", "function": "Required for cytoplasm to vacuole transport (Cvt), autophagy, nucleophagy, and mitophagy, as a part of the autophagy-specific VPS34 PI3-kinase complex I (PubMed:11157979, PubMed:11689437, PubMed:16267277, PubMed:17404498, PubMed:18701704, PubMed:19131141, PubMed:22437838, PubMed:23878393, PubMed:8224160, PubMed:9712845). This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure (PubMed:11157979, PubMed:11689437, PubMed:16267277, PubMed:17404498, PubMed:18701704, PubMed:19131141, PubMed:22437838, PubMed:23878393, PubMed:8224160, PubMed:9712845). Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II (PubMed:11157979, PubMed:12244127, PubMed:18182384, PubMed:9105038). This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes) (PubMed:11157979, PubMed:12244127, PubMed:18182384, PubMed:9105038). Also plays a role in regulation of filamentous growth (PubMed:17700056)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 39, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3P7", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0043548 phosphatidylinositol 3-kinase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010008 endosome membrane;GO:0034045 phagophore assembly site membrane", "go_biological_process": "GO:0051365 cellular response to potassium ion starvation;GO:0000045 autophagosome assembly;GO:0016236 macroautophagy;GO:0006914 autophagy;GO:0006661 phosphatidylinositol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q02948-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03018-1", "uniprot_id": [ { "id": "ESP1_YEAST", "url": "https://www.uniprot.org/uniprot/Q03018", "type": "external" } ], "mass": 187447.0, "length": 1630, "protein_name": "Separin", "gene_name": "ESP1", "organism": "Yeast", "refseq_name": "separase", "refseq_ac": [ { "id": "NP_011612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011612", "type": "external" } ], "gene_names_uniprotkb": "ESP1", "gene_names_refseq": "ESP1", "protein_names_uniprotkb": "Separin; 3.4.22.49; Separase", "protein_names_refseq": "separase", "tax_id": 559292, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (sce:YGR098C); (R-SCE-2467813)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10403247;11149918;11832211;1493337;19779198;22031224;24374639;32597660;33481703;33491328;9169869;9635435", "class_list": "", "function": "Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the MCD1/SCC1 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by securin/PDS1 protein. It also promotes anaphase spindle elongation. A component of the FEAR (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase. Cleaves SLK19., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUN0", "ec_number_list": [ { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005819 spindle;GO:0072686 mitotic spindle", "go_biological_process": "GO:0051307 meiotic chromosome separation;GO:1904750 negative regulation of protein localization to nucleolus;GO:0006508 proteolysis;GO:0006915 apoptotic process;GO:0031536 positive regulation of exit from mitosis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q03018-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03048-1", "uniprot_id": [ { "id": "COFI_YEAST", "url": "https://www.uniprot.org/uniprot/Q03048", "type": "external" } ], "mass": 15901.0, "length": 143, "protein_name": "Cofilin", "gene_name": "COF1", "organism": "Yeast", "refseq_name": "cofilin", "refseq_ac": [ { "id": "NP_013050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013050", "type": "external" } ], "gene_names_uniprotkb": "COF1; L0596", "gene_names_refseq": "COF1", "protein_names_uniprotkb": "Cofilin; Actin-depolymerizing factor 1", "protein_names_refseq": "cofilin", "tax_id": 559292, "disease": "West syndrome (Disease Ontology:DOID:0050562); vitamin B12 deficiency (Disease Ontology:DOID:0050731); autism spectrum disorder (Disease Ontology:DOID:0060041); nemaline myopathy 7 (Disease Ontology:DOID:0110934); brain compression (Disease Ontology:DOID:11457); nephrotic syndrome (Disease Ontology:DOID:1184); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); impotence (Disease Ontology:DOID:1875); gallbladder carcinoma (Disease Ontology:DOID:4948); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (sce:YLL050C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10231390;10366597;11747431;14562106;15665377;18407956;19779198;19795423;19823750;24374639;33481703;33491328;8421056;8440472;9145106;9169871;9753544", "class_list": "", "function": "Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton. In effect, yeast cofilin increases the rate of actin polymerization by making new ends available for actin subunit addition. Such a protein complex is important for the polarized growth of yeast cells., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXV8;Q05307;Q2XN65", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0016363 nuclear matrix;GO:0030479 actin cortical patch", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0043001 Golgi to plasma membrane protein transport;GO:0051014 actin filament severing;GO:0030042 actin filament depolymerization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q03048-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03281-1", "uniprot_id": [ { "id": "HEH2_YEAST", "url": "https://www.uniprot.org/uniprot/Q03281", "type": "external" } ], "mass": 76377.0, "length": 663, "protein_name": "Inner nuclear membrane protein HEH2", "gene_name": "HEH2", "organism": "Yeast", "refseq_name": "Heh2p", "refseq_ac": [ { "id": "NP_010746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010746", "type": "external" } ], "gene_names_uniprotkb": "HEH2; D8035.2", "gene_names_refseq": "HEH2", "protein_names_uniprotkb": "Inner nuclear membrane protein HEH2; Helix-extension-helix domain-containing protein 2", "protein_names_refseq": "Heh2p", "tax_id": 559292, "disease": "cataract 46 juvenile-onset (Disease Ontology:DOID:0110243)", "pathway": " (sce:YDR458C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14562095;14562106;16929305;17287358;17563356;19779198;19795423;19823750;20702584;21126336;23749301;24374639;32597660;33481703;33491328;9169867", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT82", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0034399 nuclear periphery;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0071763 nuclear membrane organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q03281-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03406-1", "uniprot_id": [ { "id": "SLD5_YEAST", "url": "https://www.uniprot.org/uniprot/Q03406", "type": "external" } ], "mass": 33948.0, "length": 294, "protein_name": "DNA replication complex GINS protein SLD5", "gene_name": "SLD5", "organism": "Yeast", "refseq_name": "DNA replication protein SLD5", "refseq_ac": [ { "id": "NP_010777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010777", "type": "external" } ], "gene_names_uniprotkb": "SLD5", "gene_names_refseq": "CDC105; SLD5", "protein_names_uniprotkb": "DNA replication complex GINS protein SLD5", "protein_names_refseq": "DNA replication protein SLD5", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR489W); (R-SCE-176974)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12730134;14690591;17322287;24374639;33491328;9169867", "class_list": "", "function": "Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTB2;Q6Q558", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031261 DNA replication preinitiation complex;GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0000811 GINS complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006260 DNA replication;GO:0000727 double-strand break repair via break-induced replication;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q03406-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03435-1", "uniprot_id": [ { "id": "NHP10_YEAST", "url": "https://www.uniprot.org/uniprot/Q03435", "type": "external" } ], "mass": 23857.0, "length": 203, "protein_name": "Non-histone protein 10", "gene_name": "NHP10", "organism": "Yeast", "refseq_name": "Nhp10p", "refseq_ac": [ { "id": "NP_010282", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010282", "type": "external" } ], "gene_names_uniprotkb": "NHP10; HMO2; YD8119.05C", "gene_names_refseq": "HMO2; NHP10", "protein_names_uniprotkb": "Non-histone protein 10; High mobility group protein 2", "protein_names_refseq": "Nhp10p", "tax_id": 559292, "disease": "mitochondrial DNA depletion syndrome 15 (Disease Ontology:DOID:0080337); Alzheimer's disease (Disease Ontology:DOID:10652); Huntington's disease (Disease Ontology:DOID:12858); Kearns-Sayre syndrome (Disease Ontology:DOID:12934); Parkinson's disease (Disease Ontology:DOID:14330); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YDL002C); (R-SCE-140342); (R-SCE-163282); (R-SCE-9837999)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "12887900;14562095;14562106;17563356;18407956;19684113;22814378;23749301;24374639;33491328;8969238;9169867", "class_list": "", "function": "Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRY6", "ec_number_list": [], "go_molecular_function": "GO:0000404 heteroduplex DNA loop binding;GO:0045027 DNA end binding", "go_cellular_component": "GO:0005634 nucleus;GO:0031011 Ino80 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q03435-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03446-1", "uniprot_id": [ { "id": "RCR2_YEAST", "url": "https://www.uniprot.org/uniprot/Q03446", "type": "external" } ], "mass": 24211.0, "length": 210, "protein_name": "Protein RCR2", "gene_name": "RCR2", "organism": "Yeast", "refseq_name": "Rcr2p", "refseq_ac": [ { "id": "NP_010286", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010286", "type": "external" } ], "gene_names_uniprotkb": "RCR2; SSH5; YD8119.09", "gene_names_refseq": "RCR2; SSH5", "protein_names_uniprotkb": "Protein RCR2; Protein SSH5; Resistance to Congo red protein 2", "protein_names_refseq": "Rcr2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR003W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562106;17330950;17563356;18407956;19779198;20702584;23749301;24374639;32597660;33481703;33491328;9169867", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRZ0", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031982 vesicle;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0072665 protein localization to vacuole", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q03446-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03558-1", "uniprot_id": [ { "id": "OYE2_YEAST", "url": "https://www.uniprot.org/uniprot/Q03558", "type": "external" } ], "mass": 45011.0, "length": 400, "protein_name": "NADPH dehydrogenase 2", "gene_name": "OYE2", "organism": "Yeast", "refseq_name": "NADPH dehydrogenase", "refseq_ac": [ { "id": "NP_012049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012049", "type": "external" } ], "gene_names_uniprotkb": "OYE2", "gene_names_refseq": "OYE2", "protein_names_uniprotkb": "NADPH dehydrogenase 2; 1.6.99.1; Old yellow enzyme 2", "protein_names_refseq": "NADPH dehydrogenase", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR179W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562095;14562106;14576278;17287358;17322287;17563356;17897954;18407956;19779198;23749301;24374639;30516470;33481703;33491328;7836424;8091229;8454584", "class_list": "", "function": "Flavin-dependent enoate reductase that catalyzes the chemo- and stereoslective hydrogenation of electron-poor alkenes. The enzyme is reduced by NADPH, and oxygen, quinones, and alpha,beta-unsaturated aldehydes and ketones can act as electron acceptors to complete catalytic turnover. The physiological oxidant remains elusive (By similarity). Has an antioxidant activity, reducing reactive oxygen species (ROS) levels when overexpressed. Formation of OYE2-OYE3 heterodimers contribute to the induction of programmed cell death upon oxidative stress (PubMed:17897954)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLC8;E9P8V8", "ec_number_list": [ { "id": "1.6.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.99.1", "type": "external" } ], "go_molecular_function": "GO:0010181 FMN binding;GO:0003959 NADPH dehydrogenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q03558-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03705-1", "uniprot_id": [ { "id": "CG121_YEAST", "url": "https://www.uniprot.org/uniprot/Q03705", "type": "external" } ], "mass": 20662.0, "length": 181, "protein_name": "EKC/KEOPS complex subunit CGI121", "gene_name": "CGI121", "organism": "Yeast", "refseq_name": "Cgi121p", "refseq_ac": [ { "id": "NP_013676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013676", "type": "external" } ], "gene_names_uniprotkb": "CGI121", "gene_names_refseq": "CGI121", "protein_names_uniprotkb": "EKC/KEOPS complex subunit CGI121; CGI-121 homolog", "protein_names_refseq": "Cgi121p", "tax_id": 559292, "disease": "Galloway-Mowat syndrome 5 (Disease Ontology:DOID:0080247)", "pathway": " (sce:YML036W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16564010;16874308;17101987;17244705;17322287;21183954;21459853;23258706;23620299;24374639;9169872", "class_list": "", "function": "Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2TBM6;D6VZD9;Q6Q5A2", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000408 EKC/KEOPS complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006310 DNA recombination;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000723 telomere maintenance;GO:1990145 maintenance of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q03705-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03714-1", "uniprot_id": [ { "id": "USA1_YEAST", "url": "https://www.uniprot.org/uniprot/Q03714", "type": "external" } ], "mass": 96653.0, "length": 838, "protein_name": "U1 SNP1-associating protein 1", "gene_name": "USA1", "organism": "Yeast", "refseq_name": "Usa1p", "refseq_ac": [ { "id": "NP_013683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013683", "type": "external" } ], "gene_names_uniprotkb": "USA1", "gene_names_refseq": "USA1", "protein_names_uniprotkb": "U1 SNP1-associating protein 1", "protein_names_refseq": "Usa1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YML029W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "11875433;14562106;16847258;16873066;17330950;18407956;19684113;19779198;19898607;19940128;20005842;20702584;21074049;21126336;22218487;23749301;24374639;32597660;33481703;33491328;9169872", "class_list": "", "function": "Scaffold protein of the endoplasmic reticulum-associated degradation (ERAD) (also known as endoplasmic reticulum quality control, ERQC) pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). Has multiple functions in ERAD including recruitment of DER1 to the HRD1 ubiquitin ligase, and regulation of HRD1 activity. Involved in oligomerization of HRD1 and in HRD1 autoubiquitination and degradation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZE5", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0036503 ERAD pathway;GO:0000398 mRNA splicing, via spliceosome;GO:1902499 positive regulation of protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q03714-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03818-1", "uniprot_id": [ { "id": "ATG16_YEAST", "url": "https://www.uniprot.org/uniprot/Q03818", "type": "external" } ], "mass": 17222.0, "length": 150, "protein_name": "Autophagy protein 16", "gene_name": "ATG16", "organism": "Yeast", "refseq_name": "Atg16p", "refseq_ac": [ { "id": "NP_013882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013882", "type": "external" } ], "gene_names_uniprotkb": "ATG16; APG15; APG16; CVT11; SAP18; YM8520.08C", "gene_names_refseq": "APG15; APG16; ATG16; CVT11; SAP18", "protein_names_uniprotkb": "Autophagy protein 16; Cytoplasm to vacuole targeting protein 11; SAP18 homolog", "protein_names_refseq": "Atg16p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR159C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10406794;11689437;11897782;14536056;14562106;15277759;15569245;16874032;17132049;17192262;18077553;19889643;20154084;22652539;23064152;23238393;24374639;33491328;34965436;8224160;8663607;9169872", "class_list": "", "function": "Stabilizes the ATG5-ATG12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Also recruits ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZY1", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0016236 macroautophagy;GO:0006914 autophagy;GO:0000422 autophagy of mitochondrion;GO:0006501 C-terminal protein lipidation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q03818-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03862-1", "uniprot_id": [ { "id": "ARX1_YEAST", "url": "https://www.uniprot.org/uniprot/Q03862", "type": "external" } ], "mass": 65213.0, "length": 593, "protein_name": "Probable metalloprotease ARX1", "gene_name": "ARX1", "organism": "Yeast", "refseq_name": "putative hydrolase", "refseq_ac": [ { "id": "NP_010386", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010386", "type": "external" } ], "gene_names_uniprotkb": "ARX1; YD8557.10c", "gene_names_refseq": "ARX1", "protein_names_uniprotkb": "Probable metalloprotease ARX1; 3.-.-.-; Associated with ribosomal export complex protein 1", "protein_names_refseq": "putative hydrolase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR101C); (R-SCE-6798695)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12374754;14562095;14562106;16648468;24374639;24909858;33481703;33491328;9169867", "class_list": "", "function": "Probable metalloprotease involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS88", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.11.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.25", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" } ], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q03862-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03899-1", "uniprot_id": [ { "id": "YD131_YEAST", "url": "https://www.uniprot.org/uniprot/Q03899", "type": "external" } ], "mass": 65243.0, "length": 556, "protein_name": "F-box protein YDR131C", "gene_name": "", "organism": "Yeast", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_010416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010416", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "F-box protein YDR131C", "protein_names_refseq": "uncharacterized protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR131C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10582239;14562095;14747994;24374639;9169867", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSB7", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex;GO:0005773 vacuole", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q03899-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03957-1", "uniprot_id": [ { "id": "CTK1_YEAST", "url": "https://www.uniprot.org/uniprot/Q03957", "type": "external" } ], "mass": 60501.0, "length": 528, "protein_name": "CTD kinase subunit alpha", "gene_name": "CTK1", "organism": "Yeast", "refseq_name": "cyclin-dependent serine/threonine protein kinase CTK1", "refseq_ac": [ { "id": "NP_012783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012783", "type": "external" } ], "gene_names_uniprotkb": "CTK1", "gene_names_refseq": "CTK1", "protein_names_uniprotkb": "CTD kinase subunit alpha; 2.7.11.23; CTD kinase 58 kDa subunit; CTD kinase subunit 1; CTDK-I subunit alpha", "protein_names_refseq": "cyclin-dependent serine/threonine protein kinase CTK1", "tax_id": 559292, "disease": "congenital heart defects, dysmorphic facial features, and intellectual developmental disorder (Disease Ontology:DOID:0112247); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); stomach cancer (Disease Ontology:DOID:10534); intellectual disability (Disease Ontology:DOID:1059); breast cancer (Disease Ontology:DOID:1612); gastric adenocarcinoma (Disease Ontology:DOID:3717); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YKL139W); (R-SCE-6796648); (R-SCE-6798695)", "pathway_count": 3, "publication_count": 29, "publication_id_list": "10488128;11118453;11311553;11751637;11875433;12504017;12629047;12684377;14562095;14562106;15047695;15161972;15520468;15870265;16182287;16984969;17088384;17287358;17545469;1820212;18407956;20489023;24374639;32597660;33481703;33491328;7565723;8196765;9110987", "class_list": "", "function": "Catalytic subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTDK-I phosphorylates 'Ser-5' if the CTD substrate is not phosphorylated at 'Ser-5', but will phosphorylate 'Ser-2' of a CTD substrate if 'Ser-5' is already phosphorylated. CTDK-I is also more reactive toward substrates that are prephosphorylated at 'Ser-2' or 'Ser-5' compared with an unphosphorylated CTD substrate, therefore efficiently creating doubly phosphorylated CTD repeats. Involved in RNA polymerase II transcriptional elongation, and through PTI1, pre-mRNA 3'-end processing. Participates in both positive and negative regulation of CTD phosphorylation. Required for DNA damage induced transcription, including the expression of the RNR genes, and reprogramming of gene expression upon amino acid starvation. Required for SET2 mediated H3K36 methylation. Also regulates H3K4 methylation. Controls the maintenance of suppressive chromatin in the coding regions of genes by both promoting H3K36 methylation, which leads to histone deacetylation, and catalyzing phosphorylation of the CTD required to localize H3K4 chromatin modification specifically to the 5' ends of genes, thereby creating a boundary for H3K4 methylation that prevents a mark associated with transcriptional initiation from spreading into the bodies of genes. Involved in RNA polymerase I transcription. Involved in telomere maintenance. Acts together with SNF1 to induce GSY2 transcription in response to glucose limitation. Involved in the adaptation to alternative carbon sources, including galactose, glycerol and ethanol, but not raffinose. Required for the integrity of the rDNA locus. Functions in translation elongation by enhancing decoding fidelity. Needed for translational accuracy by phosphorylating RPS2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX57", "ec_number_list": [ { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": 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}, { "id": "2.7.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.7.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.59", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.3.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0008024 cyclin/CDK positive transcription elongation factor complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response;GO:0006413 translational initiation;GO:0045943 positive regulation of transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q03957-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04002-1", "uniprot_id": [ { "id": "SCC2_YEAST", "url": "https://www.uniprot.org/uniprot/Q04002", "type": "external" } ], "mass": 171102.0, "length": 1493, "protein_name": "Sister chromatid cohesion protein 2", "gene_name": "SCC2", "organism": "Yeast", "refseq_name": "cohesin-loading factor complex subunit SCC2", "refseq_ac": [ { "id": "NP_010466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010466", "type": "external" } ], "gene_names_uniprotkb": "SCC2; YD9395.14", "gene_names_refseq": "SCC2", "protein_names_uniprotkb": "Sister chromatid cohesion protein 2", "protein_names_refseq": "cohesin-loading factor complex subunit SCC2", "tax_id": 559292, "disease": "Cornelia de Lange syndrome 1 (Disease Ontology:DOID:0080505); Cornelia de Lange syndrome (Disease Ontology:DOID:11725); cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YDR180W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10882066;14562106;14614819;19779198;21126336;24374639;25173104;26038942;26354421;33491328;9169867;9335333;9990856", "class_list": "", "function": "Plays a structural role in chromatin and is involved in sister chromatid cohesion (PubMed:14614819, PubMed:25173104, PubMed:26354421, PubMed:9990856). Forms a complex with SCC4 required for the stable association of the cohesin complex with chromatin, which may act by hydrolyzing ATP from SMC1 and SMC3 heads (PubMed:10882066, PubMed:14614819). Binds to the nucleosome-free promoter regions of ribosomal protein genes and tRNA genes. Involved in transcriptional regulation by cooperating with the RSC complex to maintain nucleosome exhaustion at its binding sites (PubMed:25173104)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 19, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSG3", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0043565 sequence-specific DNA binding;GO:0061775 cohesin loader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin;GO:0032116 SMC loading complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006302 double-strand break repair;GO:0007076 mitotic chromosome condensation;GO:0010468 regulation of gene expression;GO:0034087 establishment of mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q04002-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04053-1", "uniprot_id": [ { "id": "SNX41_YEAST", "url": "https://www.uniprot.org/uniprot/Q04053", "type": "external" } ], "mass": 70741.0, "length": 625, "protein_name": "Sorting nexin-41", "gene_name": "SNX41", "organism": "Yeast", "refseq_name": "Snx41p", "refseq_ac": [ { "id": "NP_010713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010713", "type": "external" } ], "gene_names_uniprotkb": "SNX41", "gene_names_refseq": "SNX41", "protein_names_uniprotkb": "Sorting nexin-41", "protein_names_refseq": "Snx41p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR425W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12554655;14562095;14562106;19779198;19795423;19823750;23749301;24374639;32597660;33481703;33491328;34965436;9169867", "class_list": "", "function": "Involved in proper sorting of the v-SNARE protein SNC1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT55", "ec_number_list": [], "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0000407 phagophore assembly site;GO:0010009 cytoplasmic side of endosome membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016236 macroautophagy;GO:0042147 retrograde transport, endosome to Golgi;GO:0000422 autophagy of mitochondrion;GO:0061709 reticulophagy", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q04053-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04080-1", "uniprot_id": [ { "id": "GPI17_YEAST", "url": "https://www.uniprot.org/uniprot/Q04080", "type": "external" } ], "mass": 60814.0, "length": 534, "protein_name": "GPI transamidase component GPI17", "gene_name": "GPI17", "organism": "Yeast", "refseq_name": "GPI-anchor transamidase GPI17", "refseq_ac": [ { "id": "NP_010722", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010722", "type": "external" } ], "gene_names_uniprotkb": "GPI17; D9461.20", "gene_names_refseq": "GPI17", "protein_names_uniprotkb": "GPI transamidase component GPI17", "protein_names_refseq": "GPI-anchor transamidase GPI17", "tax_id": 559292, "disease": "developmental and epileptic encephalopathy 95 (Disease Ontology:DOID:0070382)", "pathway": " (sce:YDR434W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11483512;14562095;14562106;16847258;19756047;24374639;9169867", "class_list": "", "function": "Component of the GPI transamidase complex. Involved in transfer of GPI to proteins., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6VT61", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005637 nuclear inner membrane;GO:0042765 GPI-anchor transamidase complex", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process;GO:0016255 attachment of GPI anchor to protein;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q04080-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04149-1", "uniprot_id": [ { "id": "MUS81_YEAST", "url": "https://www.uniprot.org/uniprot/Q04149", "type": "external" } ], "mass": 72309.0, "length": 632, "protein_name": "Crossover junction endonuclease MUS81", "gene_name": "MUS81", "organism": "Yeast", "refseq_name": "Mus81p", "refseq_ac": [ { "id": "NP_010674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010674", "type": "external" } ], "gene_names_uniprotkb": "MUS81; D9509.6; SLX3", "gene_names_refseq": "MUS81; SLX3", "protein_names_uniprotkb": "Crossover junction endonuclease MUS81; 3.1.22.-; MMS and UV-sensitive protein 81", "protein_names_refseq": "Mus81p", "tax_id": 559292, "disease": "arterial tortuosity syndrome (Disease Ontology:DOID:0050645); Marfan syndrome (Disease Ontology:DOID:14323); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (sce:YDR386W); (R-SCE-5693568)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10905349;11139495;11641278;12473680;12475932;12724407;12750322;14527420;14562106;14642571;14752007;15590332;16193328;18407956;23749301;24374639;33229814;33481703;33491328;9169867", "class_list": "", "function": "Interacts with MMS4 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks with regressed leading strands and nicked Holliday junctions. Cleavage probably occurs approximately half a helical turn upstream of the free 5'-end in these structures. May be required in mitosis for the processing of stalled replication fork intermediates arising spontaneously or subsequent to treatment with DNA damaging agents such as methylmethane sulfonate (MMS), camptothecin (CPT) or UV. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI). This involves consecutive cleavage of D-loops and nicked Holliday junctions leading to sister chromatid crossover. In contrast to MSH4-MSH5 dependent crossover, double Holliday junctions do not seem to be involved. Spore formation and viability are severely impaired in deletion strains., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VT20", "ec_number_list": [ { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0004857 enzyme inhibitor activity;GO:0046872 metal ion binding;GO:0008821 crossover junction DNA endonuclease activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0048476 Holliday junction resolvase complex", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0006974 DNA damage response;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:0006265 DNA topological change;GO:0006308 DNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q04149-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04217-1", "uniprot_id": [ { "id": "DHR1_YEAST", "url": "https://www.uniprot.org/uniprot/Q04217", "type": "external" } ], "mass": 144955.0, "length": 1267, "protein_name": "Probable ATP-dependent RNA helicase DHR1", "gene_name": "ECM16", "organism": "Yeast", "refseq_name": "ATP-dependent RNA helicase ECM16", "refseq_ac": [ { "id": "NP_013847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013847", "type": "external" } ], "gene_names_uniprotkb": "ECM16; DHR1; YM9553.04", "gene_names_refseq": "DHR1; ECM16", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DHR1; 3.6.4.13; DEAH box RNA helicase DHR1; Extracellular mutant protein 16", "protein_names_refseq": "ATP-dependent RNA helicase ECM16", "tax_id": 559292, "disease": "microcephaly (Disease Ontology:DOID:10907); 46,XY complete gonadal dysgenesis (Disease Ontology:DOID:14448)", "pathway": " (sce:YMR128W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10982841;12068309;14562106;19779198;19795423;19823750;24374639;32597660;33481703;33491328;9169872", "class_list": "", "function": "Probable ATP-binding RNA helicase. Required for 18S rRNA synthesis. May play a role in restructuring of the pre-rRNA., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VZV1", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.1.1.260", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.260", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004386 helicase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0030686 90S preribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0042254 ribosome biogenesis;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q04217-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04272-1", "uniprot_id": [ { "id": "VPS20_YEAST", "url": "https://www.uniprot.org/uniprot/Q04272", "type": "external" } ], "mass": 25638.0, "length": 221, "protein_name": "Vacuolar protein sorting-associated protein 20", "gene_name": "VPS20", "organism": "Yeast", "refseq_name": "ESCRT-III subunit protein VPS20", "refseq_ac": [ { "id": "NP_013794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013794", "type": "external" } ], "gene_names_uniprotkb": "VPS20; ASI10; CHM6; VPT20; YM9582.02C", "gene_names_refseq": "CHM6; VPL10; VPS20; VPT20", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 20; Amino acid sensor-independent protein 10; Charged multivesicular body protein 6; ESCRT-III complex subunit VPS20; Vacuolar protein-targeting protein 20", "protein_names_refseq": "ESCRT-III subunit protein VPS20", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR077C); (R-SCE-1632852); (R-SCE-917729); (R-SCE-9668328)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "11251082;11559748;12194857;12953057;14562095;14562106;15371534;15469844;15665377;17949747;18407956;23749301;24374639;33481703;33491328;9169872;9748261", "class_list": "", "function": "Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole. Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment of late-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. Required for the oligomerization of SNF7 into a membrane-associated filament. The VPS20-SNF7 subcomplex is responsible for the membrane association of the ESCRT-III complex. Also required for the RIM101 repressor proteolytic activation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZQ1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0015031 protein transport;GO:0007031 peroxisome organization;GO:0006900 vesicle budding from membrane;GO:0070676 intralumenal vesicle formation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q04272-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04431-1", "uniprot_id": [ { "id": "ZWINT_YEAST", "url": "https://www.uniprot.org/uniprot/Q04431", "type": "external" } ], "mass": 44675.0, "length": 385, "protein_name": "Outer kinetochore KNL1 complex subunit KRE28", "gene_name": "KRE28", "organism": "Yeast", "refseq_name": "Kre28p", "refseq_ac": [ { "id": "NP_010821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010821", "type": "external" } ], "gene_names_uniprotkb": "KRE28", "gene_names_refseq": "KRE28", "protein_names_uniprotkb": "Outer kinetochore KNL1 complex subunit KRE28; Spindle pole body component KRE28", "protein_names_refseq": "Kre28p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR532C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;14565975;17322287;19779198;19893618;21126336;24374639;32997987;33491328;35042402;9169867", "class_list": "", "function": "Acts as a component of the outer kinetochore KNL1 complex that facilitates microtubule-kinetochore interactions and the spindle assembly checkpoint (PubMed:19893618, PubMed:32997987, PubMed:35042402). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:19893618). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:19893618, PubMed:32997987). The KNL1 complex is required for kinetochore binding by the kMAPs (kinetochore-bound microtubule-associated proteins) BIM1, BIK1 and SLK19, and motors CIN8 and KAR3 (PubMed:19893618). Required during meiosis (PubMed:35042402)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTF3;Q6Q537", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0000776 kinetochore;GO:0000940 outer kinetochore;GO:0180019 Knl1/Spc105 complex", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0031619 homologous chromosome orientation in meiotic metaphase I;GO:1905325 regulation of meiosis I spindle assembly checkpoint", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q04431-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04491-1", "uniprot_id": [ { "id": "SEC13_YEAST", "url": "https://www.uniprot.org/uniprot/Q04491", "type": "external" } ], "mass": 33043.0, "length": 297, "protein_name": "Protein transport protein SEC13", "gene_name": "SEC13", "organism": "Yeast", "refseq_name": "GTPase-activating protein SEC13", "refseq_ac": [ { "id": "NP_013309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013309", "type": "external" } ], "gene_names_uniprotkb": "SEC13; ANU3; L8167.4", "gene_names_refseq": "ANU3; SEC13", "protein_names_uniprotkb": "Protein transport protein SEC13", "protein_names_refseq": "GTPase-activating protein SEC13", "tax_id": 559292, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (sce:YLR208W); (R-SCE-204005)", "pathway_count": 2, "publication_count": 39, "publication_id_list": "10564255;10684247;10720463;10747086;11389436;11535824;11560939;11717432;11823431;12215173;12235121;12475940;12671686;12757749;12791264;12791295;14562095;14562106;14627716;21454883;2188733;22814378;24374639;33481703;33491328;6996832;7026045;8432727;8548805;8565072;8909535;9023343;9169871;9190202;9199164;9325247;9409822;9427388;9568718", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC) and the COPII coat. It is one of 5 proteins constituting the COPII coat, which is involved in anterograde (ER to Golgi) double-membrane transport vesicle formation. First the small GTPase SAR1, activated by and binding to the integral ER membrane protein SEC12, exchanges GDP for GTP and recruits the heterodimer SEC23/24, which in turn recruits the heterotetramer SEC13-SEC31. The polymerization of COPII coat complexes then causes physically the deformation (budding) of the membrane, leading to the creation of a transport vesicle. The COPII complex is dissociated upon SAR1-GTP hydrolysis to SAR1-GDP. SEC23 functions as the SAR1 GTPase activating protein, whose activity is stimulated in the presence of SEC13/31. SEC13 is directly or indirectly required for normal ER membrane and nuclear envelope morphology. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution. Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYK9", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0071944 cell periphery", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006913 nucleocytoplasmic transport;GO:0045893 positive regulation of DNA-templated transcription;GO:0032008 positive regulation of TOR signaling;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q04491-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04493-1", "uniprot_id": [ { "id": "PFD5_YEAST", "url": "https://www.uniprot.org/uniprot/Q04493", "type": "external" } ], "mass": 18356.0, "length": 163, "protein_name": "Prefoldin subunit 5", "gene_name": "GIM5", "organism": "Yeast", "refseq_name": "Gim5p", "refseq_ac": [ { "id": "NP_013616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013616", "type": "external" } ], "gene_names_uniprotkb": "GIM5; PFD5", "gene_names_refseq": "GIM5; PFD5", "protein_names_uniprotkb": "Prefoldin subunit 5; Genes involved in microtubule biogenesis protein 5; Gim complex subunit 5; GimC subunit 5", "protein_names_refseq": "Gim5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YML094W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;24374639;33491328;9169872;9463374;9878052", "class_list": "", "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0J1", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016272 prefoldin complex", "go_biological_process": "GO:0006457 protein folding;GO:0007021 tubulin complex assembly;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:1990114 RNA polymerase II core complex assembly;GO:1990113 RNA polymerase I assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q04493-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04511-1", "uniprot_id": [ { "id": "UFO1_YEAST", "url": "https://www.uniprot.org/uniprot/Q04511", "type": "external" } ], "mass": 76860.0, "length": 668, "protein_name": "Ubiquitin ligase complex F-box protein UFO1", "gene_name": "UFO1", "organism": "Yeast", "refseq_name": "SCF ubiquitin ligase complex subunit UFO1", "refseq_ac": [ { "id": "NP_013622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013622", "type": "external" } ], "gene_names_uniprotkb": "UFO1", "gene_names_refseq": "UFO1", "protein_names_uniprotkb": "Ubiquitin ligase complex F-box protein UFO1", "protein_names_refseq": "SCF ubiquitin ligase complex subunit UFO1", "tax_id": 559292, "disease": "", "pathway": " (sce:YML088W); (R-SCE-983168)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10963670;11283612;14562106;14747994;18407956;19779198;23749301;24374639;32597660;33481703;33491328;33502312;9169872", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0J5", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0071406 cellular response to methylmercury", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q04511-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04549-1", "uniprot_id": [ { "id": "ARP10_YEAST", "url": "https://www.uniprot.org/uniprot/Q04549", "type": "external" } ], "mass": 33018.0, "length": 284, "protein_name": "Actin-like protein ARP10", "gene_name": "ARP10", "organism": "Yeast", "refseq_name": "Arp10p", "refseq_ac": [ { "id": "NP_010391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010391", "type": "external" } ], "gene_names_uniprotkb": "ARP10; YD8557.15; YD9727.02", "gene_names_refseq": "ARP10", "protein_names_uniprotkb": "Actin-like protein ARP10", "protein_names_refseq": "Arp10p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR106W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16291862;17322287;24374639;9169867;9290209", "class_list": "", "function": "Pointed-end-associated component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding (By similarity). The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. May regulate the association of the dynactin complex with the plasma membrane., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS92;Q03869", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0015629 actin cytoskeleton;GO:0005869 dynactin complex;GO:0000812 Swr1 complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030048 actin filament-based movement;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q04549-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04601-1", "uniprot_id": [ { "id": "APC4_YEAST", "url": "https://www.uniprot.org/uniprot/Q04601", "type": "external" } ], "mass": 75256.0, "length": 652, "protein_name": "Anaphase-promoting complex subunit 4", "gene_name": "APC4", "organism": "Yeast", "refseq_name": "anaphase promoting complex subunit 4", "refseq_ac": [ { "id": "NP_010403", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010403", "type": "external" } ], "gene_names_uniprotkb": "APC4", "gene_names_refseq": "APC4", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 4", "protein_names_refseq": "anaphase promoting complex subunit 4", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR118W); (R-SCE-983168)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14562095;14562106;24374639;9169867;9469814", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSA3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005680 anaphase-promoting complex;GO:0034399 nuclear periphery", "go_biological_process": "GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle;GO:0016567 protein ubiquitination;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q04601-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04632-1", "uniprot_id": [ { "id": "COG8_YEAST", "url": "https://www.uniprot.org/uniprot/Q04632", "type": "external" } ], "mass": 69829.0, "length": 607, "protein_name": "Conserved oligomeric Golgi complex subunit 8", "gene_name": "COG8", "organism": "Yeast", "refseq_name": "Golgi transport complex subunit COG8", "refseq_ac": [ { "id": "NP_013640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013640", "type": "external" } ], "gene_names_uniprotkb": "COG8; DOR1", "gene_names_refseq": "COG8; DOR1", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 8; COG complex subunit 8; Component of oligomeric Golgi complex 8", "protein_names_refseq": "Golgi transport complex subunit COG8", "tax_id": 559292, "disease": "congenital disorder of glycosylation type IIh (Disease Ontology:DOID:0070260)", "pathway": " (sce:YML071C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11703943;14562106;15047703;17563356;19779198;21126336;22814378;23749301;24374639;33481703;33491328;9169872", "class_list": "", "function": "Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZA2;Q03641", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0000301 retrograde transport, vesicle recycling within Golgi;GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q04632-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04651-1", "uniprot_id": [ { "id": "ERV41_YEAST", "url": "https://www.uniprot.org/uniprot/Q04651", "type": "external" } ], "mass": 40706.0, "length": 352, "protein_name": "ER-derived vesicles protein ERV41", "gene_name": "ERV41", "organism": "Yeast", "refseq_name": "Erv41p", "refseq_ac": [ { "id": "NP_013644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013644", "type": "external" } ], "gene_names_uniprotkb": "ERV41", "gene_names_refseq": "ERV41", "protein_names_uniprotkb": "ER-derived vesicles protein ERV41", "protein_names_refseq": "Erv41p", "tax_id": 559292, "disease": "", "pathway": " (sce:YML067C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10713261;11157978;11758914;12426381;14562106;16107716;23524136;24374639;9169872", "class_list": "", "function": "Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi (PubMed:11157978, PubMed:12426381). The C-terminal Ile-Leu motif is required for exit from the endoplasmic reticulum (PubMed:12426381). Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (PubMed:12426381)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZA6;E9PAD9", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0012507 ER to Golgi transport vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q04651-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04693-1", "uniprot_id": [ { "id": "RSE1_YEAST", "url": "https://www.uniprot.org/uniprot/Q04693", "type": "external" } ], "mass": 153784.0, "length": 1361, "protein_name": "Pre-mRNA-splicing factor RSE1", "gene_name": "RSE1", "organism": "Yeast", "refseq_name": "U2 snRNP complex subunit RSE1", "refseq_ac": [ { "id": "NP_013663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013663", "type": "external" } ], "gene_names_uniprotkb": "RSE1; SAP130; YM9827.03C", "gene_names_refseq": "RSE1", "protein_names_uniprotkb": "Pre-mRNA-splicing factor RSE1; RNA splicing and ER to Golgi transport factor 1; Spliceosome-associated protein 130", "protein_names_refseq": "U2 snRNP complex subunit RSE1", "tax_id": 559292, "disease": "", "pathway": " (sce:YML049C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10369685;10449419;11884590;14517302;15565172;18407956;24374639;32597660;33229814;33481703;33491328;9169872;9819400", "class_list": "", "function": "Involved in G2/M transition (By similarity). Required for pre-mRNA splicing and endoplasmic reticulum (ER) to Golgi secretion pathway. U2 snRNPs associated protein required for the pre-spliceosome assembly. The involvement in ER to Golgi secretion is probably indirect and due to the splicing of the pre-mRNA coding for SAR1, a small GTP-binding protein required for COPII vesicle formation from the ER., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VZC6", "ec_number_list": [], "go_molecular_function": "GO:0030620 U2 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005686 U2 snRNP;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:1903241 U2-type prespliceosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q04693-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05016-1", "uniprot_id": [ { "id": "YM71_YEAST", "url": "https://www.uniprot.org/uniprot/Q05016", "type": "external" } ], "mass": 29158.0, "length": 267, "protein_name": "NADP-dependent 3-hydroxy acid dehydrogenase", "gene_name": "YM9959.08C", "organism": "Yeast", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "YM9959.08C", "gene_names_refseq": "", "protein_names_uniprotkb": "NADP-dependent 3-hydroxy acid dehydrogenase; 1.1.1.-; 1.1.1.381; L-allo-threonine dehydrogenase", "protein_names_refseq": "", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR226C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12535615;14562095;14562106;19779198;19795423;19823750;24374639;32597660;33481703;33491328;9169872", "class_list": "", "function": "NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids. Catalyzes the NADP-dependent oxidation of L-allo-threonine to L-2-amino-3-keto-butyrate, which is spontaneously decarboxylated into aminoacetone. Also acts on D-threonine, L-serine, D-serine, D-3-hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L-glycerate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W051", "ec_number_list": [ { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.381", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.381", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0004090 carbonyl reductase (NADPH) activity;GO:0031132 serine 3-dehydrogenase activity;GO:0052588 diacetyl reductase ((S)-acetoin forming) (NAD+) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0045149 acetoin metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q05016-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05027-1", "uniprot_id": [ { "id": "TAF9_YEAST", "url": "https://www.uniprot.org/uniprot/Q05027", "type": "external" } ], "mass": 17315.0, "length": 157, "protein_name": "SAGA complex/transcription factor TFIID complex subunit TAF9", "gene_name": "TAF9", "organism": "Yeast", "refseq_name": "chromatin modification protein", "refseq_ac": [ { "id": "NP_013963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013963", "type": "external" } ], "gene_names_uniprotkb": "TAF9; TAF17; YM9959.18", "gene_names_refseq": "TAF17; TAF9", "protein_names_uniprotkb": "SAGA complex/transcription factor TFIID complex subunit TAF9; TAFII-17; TAFII20; TBP-associated factor 17 kDa; TBP-associated factor 9; Transcription initiation factor TFIID subunit 9", "protein_names_refseq": "chromatin modification protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR236W); (R-SCE-674695); (R-SCE-6807505); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042)", "pathway_count": 7, "publication_count": 34, "publication_id_list": "10026213;10788514;10864329;11238921;11295558;11473260;12052880;12093743;12138208;12446794;12516863;12840001;14562095;14562106;15260971;15448131;15647753;18407956;19779198;20190278;21734642;23749301;24374639;25216679;28918903;31969703;33229814;33481703;33491328;33864814;9169872;9674426;9695952;9844639", "class_list": "", "function": "Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex (PubMed:10788514, PubMed:12052880, PubMed:12138208, PubMed:25216679, PubMed:9844639). Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription (PubMed:11238921, PubMed:12516863, PubMed:15448131). SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription (PubMed:10864329, PubMed:25216679, PubMed:9674426). At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module) (PubMed:12840001, PubMed:31969703). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B (PubMed:10026213). SAGA interacts with DNA via upstream activating sequences (UASs) (PubMed:28918903). Also identified in a modified version of SAGA named SALSA or SLIK (PubMed:12446794). The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities (PubMed:33864814)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W062", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005669 transcription factor TFIID complex;GO:0000124 SAGA complex;GO:0046695 SLIK (SAGA-like) complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:0006366 transcription by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "Q05027-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05050-1", "uniprot_id": [ { "id": "EIS1_YEAST", "url": "https://www.uniprot.org/uniprot/Q05050", "type": "external" } ], "mass": 93345.0, "length": 843, "protein_name": "Eisosome protein 1", "gene_name": "EIS1", "organism": "Yeast", "refseq_name": "Eis1p", "refseq_ac": [ { "id": "NP_013744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013744", "type": "external" } ], "gene_names_uniprotkb": "EIS1; YM9973.04C", "gene_names_refseq": "EIS1", "protein_names_uniprotkb": "Eisosome protein 1", "protein_names_refseq": "Eis1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR031C)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "14562095;14562106;15665377;17287358;17330950;17563356;17761666;18407956;19269952;19684113;19779198;19795423;19823750;20489023;20526336;20702584;21126336;21177495;22218487;22814378;23749301;24374639;24909858;30516470;32597660;33229814;33481703;33491328;9169872", "class_list": "", "function": "Required for normal formation of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on plasma membrane and mark the site of endocytosis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 16, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 16, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 16, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 85, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "D6VZK5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0032126 eisosome", "go_biological_process": "GO:0070941 eisosome assembly", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "Q05050-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05636-1", "uniprot_id": [ { "id": "RRP45_YEAST", "url": "https://www.uniprot.org/uniprot/Q05636", "type": "external" } ], "mass": 33962.0, "length": 305, "protein_name": "Exosome complex component RRP45", "gene_name": "RRP45", "organism": "Yeast", "refseq_name": "exosome non-catalytic core subunit RRP45", "refseq_ac": [ { "id": "NP_010566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010566", "type": "external" } ], "gene_names_uniprotkb": "RRP45; D9954.1", "gene_names_refseq": "RRP45", "protein_names_uniprotkb": "Exosome complex component RRP45; Ribosomal RNA-processing protein 45", "protein_names_refseq": "exosome non-catalytic core subunit RRP45", "tax_id": 559292, "disease": "pontocerebellar hypoplasia type 1D (Disease Ontology:DOID:0112323)", "pathway": " (sce:YDR280W); (R-SCE-429958); (R-SCE-450385); (R-SCE-450513); (R-SCE-6791226)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10465791;12837249;14562095;14562106;17173052;17174896;17322287;19879841;24374639;9169867", "class_list": "", "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP45 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSR0", "ec_number_list": [], "go_molecular_function": "GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000176 nuclear exosome (RNase complex);GO:0000177 cytoplasmic exosome (RNase complex)", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0034473 U1 snRNA 3'-end processing;GO:0034476 U5 snRNA 3'-end processing;GO:0006396 RNA processing;GO:0016075 rRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q05636-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05785-1", "uniprot_id": [ { "id": "ENT2_YEAST", "url": "https://www.uniprot.org/uniprot/Q05785", "type": "external" } ], "mass": 71807.0, "length": 613, "protein_name": "Epsin-2", "gene_name": "ENT2", "organism": "Yeast", "refseq_name": "epsin", "refseq_ac": [ { "id": "NP_013307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013307", "type": "external" } ], "gene_names_uniprotkb": "ENT2", "gene_names_refseq": "ENT2", "protein_names_uniprotkb": "Epsin-2", "protein_names_refseq": "epsin", "tax_id": 559292, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (sce:YLR206W); (R-SCE-8856825)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10449404;11694597;14562106;15665377;17287358;17330950;17563356;18407956;19684113;19779198;20702584;21126336;21177495;22106047;22218487;23749301;24374639;30516470;32597660;33481703;33491328;9169871", "class_list": "", "function": "Binds to membranes enriched in phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYK7", "ec_number_list": [], "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0005543 phospholipid binding;GO:0030276 clathrin binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0043332 mating projection tip", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0000147 actin cortical patch assembly", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q05785-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05930-1", "uniprot_id": [ { "id": "MDM30_YEAST", "url": "https://www.uniprot.org/uniprot/Q05930", "type": "external" } ], "mass": 70528.0, "length": 598, "protein_name": "Mitochondrial distribution and morphology protein 30", "gene_name": "MDM30", "organism": "Yeast", "refseq_name": "SCF ubiquitin ligase complex subunit MDM30", "refseq_ac": [ { "id": "NP_013472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013472", "type": "external" } ], "gene_names_uniprotkb": "MDM30", "gene_names_refseq": "DSG1; MDM30", "protein_names_uniprotkb": "Mitochondrial distribution and morphology protein 30", "protein_names_refseq": "SCF ubiquitin ligase complex subunit MDM30", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR368W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11907266;12808031;14576278;14747994;16735578;18353967;21385840;21502136;24374639;9169871", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). Recognizes FZO1 and regulates the amount of FZO1. Regulatory factor for the mitochondrial fusion machinery. Required for mitochondrial DNA maintenance., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ05", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0007005 mitochondrion organization;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0008053 mitochondrial fusion;GO:0010793 regulation of mRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q05930-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05947-1", "uniprot_id": [ { "id": "UCC1_YEAST", "url": "https://www.uniprot.org/uniprot/Q05947", "type": "external" } ], "mass": 42754.0, "length": 369, "protein_name": "F-box protein UCC1", "gene_name": "UCC1", "organism": "Yeast", "refseq_name": "Ucc1p", "refseq_ac": [ { "id": "NP_013325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013325", "type": "external" } ], "gene_names_uniprotkb": "UCC1", "gene_names_refseq": "UCC1", "protein_names_uniprotkb": "F-box protein UCC1; Ubiquitination of citrate synthase in the glyoxylate cycle protein 1", "protein_names_refseq": "Ucc1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR224W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10582239;11283612;14747994;24374639;25982115;9169871", "class_list": "", "function": "Substrate recognition component of the SKP1-CUL1-F-box protein E3 ubiquitin-protein ligase complex SCF(UCC1) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10582239, PubMed:25982115). The SCF(UCC1) complex acts as a metabolic switch for the glyoxylate cycle and regulates the level of CIT2 protein to maintain citrate homeostasis (PubMed:25982115)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYM4", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q05947-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05979-1", "uniprot_id": [ { "id": "KYNU_YEAST", "url": "https://www.uniprot.org/uniprot/Q05979", "type": "external" } ], "mass": 51032.0, "length": 453, "protein_name": "Kynureninase", "gene_name": "BNA5", "organism": "Yeast", "refseq_name": "kynureninase", "refseq_ac": [ { "id": "NP_013332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013332", "type": "external" } ], "gene_names_uniprotkb": "BNA5; L8083.14", "gene_names_refseq": "BNA5", "protein_names_uniprotkb": "Kynureninase; 3.7.1.3; Biosynthesis of nicotinic acid protein 5; L-kynurenine hydrolase", "protein_names_refseq": "kynureninase", "tax_id": 559292, "disease": "hydroxykynureninuria (Disease Ontology:DOID:0112257); hypertension (Disease Ontology:DOID:10763)", "pathway": " (sce:YLR231C); (R-SCE-71240)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12062417;14562095;14562106;24374639;33491328;9169871", "class_list": "", "function": "Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYN2", "ec_number_list": [ { "id": "3.7.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.7.1.3", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0030429 kynureninase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0097268 cytoophidium", "go_biological_process": "GO:0097053 L-kynurenine catabolic process;GO:0019441 L-tryptophan catabolic process to kynurenine;GO:0019805 quinolinate biosynthetic process;GO:0043420 anthranilate metabolic process;GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q05979-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06096-1", "uniprot_id": [ { "id": "COG4_YEAST", "url": "https://www.uniprot.org/uniprot/Q06096", "type": "external" } ], "mass": 98666.0, "length": 861, "protein_name": "Conserved oligomeric Golgi complex subunit 4", "gene_name": "COG4", "organism": "Yeast", "refseq_name": "Golgi transport complex subunit COG4", "refseq_ac": [ { "id": "NP_015430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015430", "type": "external" } ], "gene_names_uniprotkb": "COG4; P8283.16; SEC38; SGF1", "gene_names_refseq": "COD1; COG4; SEC38; SGF1", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 4; COG complex subunit 4; Component of oligomeric Golgi complex 4; Protein SEC38", "protein_names_refseq": "Golgi transport complex subunit COG4", "tax_id": 559292, "disease": "congenital disorder of glycosylation type IIj (Disease Ontology:DOID:0070262); Saul-Wilson syndrome (Disease Ontology:DOID:0111673)", "pathway": " (sce:YPR105C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11703943;11733049;12006647;12011112;14562106;15047703;17322287;19795423;19823750;21126336;21177495;23749301;24374639;32597660;33481703;33491328;9169875", "class_list": "", "function": "Acts as essential component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. Possesses ATPase activity., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4A3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0016236 macroautophagy;GO:0000301 retrograde transport, vesicle recycling within Golgi;GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway;GO:0006891 intra-Golgi vesicle-mediated transport;GO:0000425 pexophagy", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q06096-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06102-1", "uniprot_id": [ { "id": "YTH1_YEAST", "url": "https://www.uniprot.org/uniprot/Q06102", "type": "external" } ], "mass": 24553.0, "length": 208, "protein_name": "mRNA 3'-end-processing protein YTH1", "gene_name": "YTH1", "organism": "Yeast", "refseq_name": "cleavage polyadenylation factor RNA-binding subunit YTH1", "refseq_ac": [ { "id": "NP_015432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015432", "type": "external" } ], "gene_names_uniprotkb": "YTH1", "gene_names_refseq": "YTH1", "protein_names_uniprotkb": "mRNA 3'-end-processing protein YTH1; Yeast 30 kDa homolog 1", "protein_names_refseq": "cleavage polyadenylation factor RNA-binding subunit YTH1", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR107C); (R-SCE-77595)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10899131;11238938;12626716;12819204;14562095;14562106;17322287;24374639;33491328;9169875;9224719", "class_list": "", "function": "RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4A5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q06102-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06106-1", "uniprot_id": [ { "id": "MRD1_YEAST", "url": "https://www.uniprot.org/uniprot/Q06106", "type": "external" } ], "mass": 101120.0, "length": 887, "protein_name": "Multiple RNA-binding domain-containing protein 1", "gene_name": "MRD1", "organism": "Yeast", "refseq_name": "RNA-binding ribosome biosynthesis protein MRD1", "refseq_ac": [ { "id": "NP_015437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015437", "type": "external" } ], "gene_names_uniprotkb": "MRD1", "gene_names_refseq": "MRD1", "protein_names_uniprotkb": "Multiple RNA-binding domain-containing protein 1", "protein_names_refseq": "RNA-binding ribosome biosynthesis protein MRD1", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR112C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11884397;14562106;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;32597660;33481703;33491328;9169875", "class_list": "", "function": "Involved in pre-rRNA processing. Required for maintaining steady-state levels of 40S ribosomal subunit. Required for the initial processing of pre-rRNA at the A0 to A2 sites, leading to the processing of the 23S pre-rRNA intermediate to the 18S rRNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4B1", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0042134 rRNA primary transcript binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex;GO:0030686 90S preribosome", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0071028 nuclear mRNA surveillance;GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q06106-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06150-1", "uniprot_id": [ { "id": "BOP2_YEAST", "url": "https://www.uniprot.org/uniprot/Q06150", "type": "external" } ], "mass": 66344.0, "length": 570, "protein_name": "Protein BOP2", "gene_name": "BOP2", "organism": "Yeast", "refseq_name": "Bop2p", "refseq_ac": [ { "id": "NP_013369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013369", "type": "external" } ], "gene_names_uniprotkb": "BOP2", "gene_names_refseq": "BOP2", "protein_names_uniprotkb": "Protein BOP2; Bypass of PAM1 protein 2", "protein_names_refseq": "Bop2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR267W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17563356;18407956;19779198;24374639;32597660;33481703;33491328;9169871", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYR5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q06150-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06159-1", "uniprot_id": [ { "id": "ATG39_YEAST", "url": "https://www.uniprot.org/uniprot/Q06159", "type": "external" } ], "mass": 46628.0, "length": 398, "protein_name": "Autophagy-related protein 39", "gene_name": "ATG39", "organism": "Yeast", "refseq_name": "Atg39p", "refseq_ac": [ { "id": "NP_013415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013415", "type": "external" } ], "gene_names_uniprotkb": "ATG39", "gene_names_refseq": "ATG39", "protein_names_uniprotkb": "Autophagy-related protein 39", "protein_names_refseq": "Atg39p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR312C)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "24374639;26040717;33491328;9169871", "class_list": "", "function": "Acts as a receptor for reticulophagy and nucleophagy. Directs autophagic sequestration of double-membrane vesicles derived from the nuclear envelope and perinuclear endoplasmic reticulum (pnER) into autophagosomes. Is not required for the cytoplasm-to-vacuole targeting pathway, mitophagy, pexophagy, and non-selective autophagy., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYV5", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0097038 perinuclear endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0034045 phagophore assembly site membrane;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0044804 nucleophagy;GO:0006995 cellular response to nitrogen starvation;GO:0061709 reticulophagy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q06159-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06164-1", "uniprot_id": [ { "id": "MMS22_YEAST", "url": "https://www.uniprot.org/uniprot/Q06164", "type": "external" } ], "mass": 167683.0, "length": 1454, "protein_name": "E3 ubiquitin-protein ligase substrate receptor MMS22", "gene_name": "MMS22", "organism": "Yeast", "refseq_name": "Mms22p", "refseq_ac": [ { "id": "NP_013424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013424", "type": "external" } ], "gene_names_uniprotkb": "MMS22; SLM2", "gene_names_refseq": "MMS22; SLM2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase substrate receptor MMS22; Methyl methanesulfonate-sensitivity protein 22; Synthetically lethal with MCM10 protein 2", "protein_names_refseq": "Mms22p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR320W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12482937;12694535;15718301;16024805;16569515;18321796;18704118;20139071;21593207;24209620;24374639;33481703;33491328;9169871", "class_list": "", "function": "Substrate targeting component of a cullin-RING-based E3 ubiquitin-protein ligase complex RTT101(MMS1-MMS22). RTT101(MMS1-MMS22) promotes fork progression through damaged DNA or natural pause sites by stabilizing replication proteins like the replication fork-pausing complex (FPC) and leading-strand polymerase at stalled replication forks. RTT101(MMS1-MMS22) ubiquitinates the acetylated histones H3K56ac-H4 at lysine residues H3K121, H3K122 and H3K125. Ubiquitination is required for efficient histone deposition during replication-coupled nucleosome assembly, probably by facilitating the transfer of H3-H4 from ASF1 to other chaperones involved in histone deposition., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYW3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0035361 Cul8-RING ubiquitin ligase complex", "go_biological_process": "GO:0051301 cell division;GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0006334 nucleosome assembly;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q06164-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06178-1", "uniprot_id": [ { "id": "NMA1_YEAST", "url": "https://www.uniprot.org/uniprot/Q06178", "type": "external" } ], "mass": 45859.0, "length": 401, "protein_name": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1", "gene_name": "NMA1", "organism": "Yeast", "refseq_name": "nicotinamide-nucleotide adenylyltransferase NMA1", "refseq_ac": [ { "id": "NP_013432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013432", "type": "external" } ], "gene_names_uniprotkb": "NMA1; L8543.16", "gene_names_refseq": "NMA1", "protein_names_uniprotkb": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; 2.7.7.18; 2.7.7.1; NAD(+) diphosphorylase 1; NAD(+) pyrophosphorylase 1; NMN adenylyltransferase 1; NMN/NaMN adenylyltransferase 1; NMNAT 1; NaMN adenylyltransferase 1; NaMNAT 1; Nicotinamide-nucleotide adenylyltransferase 1; Nicotinate-nucleotide adenylyltransferase 1", "protein_names_refseq": "nicotinamide-nucleotide adenylyltransferase NMA1", "tax_id": 559292, "disease": "Leber congenital amaurosis 9 (Disease Ontology:DOID:0110005); spondyloepiphyseal dysplasia, sensorineural hearing loss, intellectual developmental disorder, and Leber congenital amaurosis (Disease Ontology:DOID:0112290); sciatic neuropathy (Disease Ontology:DOID:11446); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); neurodegenerative disease (Disease Ontology:DOID:1289); glaucoma (Disease Ontology:DOID:1686); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (sce:YLR328W); (R-SCE-196807)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10428462;11884393;12597897;14562095;14562106;17330950;18098602;18407956;19684113;19779198;20702584;23749301;24374639;24759102;3013296;32597660;33481703;33491328;4291828;9169871", "class_list": "", "function": "Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate to form deamido-NAD(+) (NaAD). Key enzyme in both de novo and salvage pathways for NAD(+) biosynthesis. Predominantly acts in the salvage pathways via NMN., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYX0", "ec_number_list": [ { "id": "2.7.7.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.1", "type": "external" }, { "id": "2.7.7.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0004515 nicotinate-nucleotide adenylyltransferase activity;GO:0000309 nicotinamide-nucleotide adenylyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0009435 NAD+ biosynthetic process;GO:0034355 NAD+ biosynthetic process via the salvage pathway", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q06178-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06211-1", "uniprot_id": [ { "id": "MMS1_YEAST", "url": "https://www.uniprot.org/uniprot/Q06211", "type": "external" } ], "mass": 161238.0, "length": 1407, "protein_name": "E3 ubiquitin-protein ligase linker protein MMS1", "gene_name": "MMS1", "organism": "Yeast", "refseq_name": "Mms1p", "refseq_ac": [ { "id": "NP_015490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015490", "type": "external" } ], "gene_names_uniprotkb": "MMS1; KIM3; RTT108; SLM6", "gene_names_refseq": "MMS1; RTT108; SLM6", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase linker protein MMS1; Methyl methanesulfonate-sensitivity protein 1; Regulator of Ty1 transposition protein 108; Synthetically lethal with MCM10 protein 6", "protein_names_refseq": "Mms1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR164W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11779788;11810260;12482937;12694535;16024805;16121259;17330950;18321796;18407956;18704118;19390089;19779198;20139071;21593207;24209620;24374639;32597660;33481703;33491328;9169875", "class_list": "", "function": "Component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes (CRLs), which mediate the ubiquitination of target proteins. The CRL associates with CDC34 as the E2 ubiquitin-conjugating enzyme. The functional specificity of the CRL depends on the type of the associated substrate receptor protein. RTT101(MMS1-MMS22) promotes fork progression through damaged DNA or natural pause sites by stabilizing replication proteins like the replication fork-pausing complex (FPC) and leading-strand polymerase at stalled replication forks. RTT101(MMS1-MMS22) ubiquitinates the acetylated histones H3K56ac-H4 at lysine residues H3K121, H3K122 and H3K125. Ubiquitination is required for efficient histone deposition during replication-coupled nucleosome assembly, probably by facilitating the transfer of H3-H4 from ASF1 to other chaperones involved in histone deposition. RTT101(MMS1-CRT10) may regulate nucleotide synthesis through transcriptional regulation of ribonucleotide reductase. RTT101(MMS1) is also involved in the non-functional rRNA decay (NRD) of 25S rRNA through the selective, ubiquitination-dependent degradation of nonfunctional ribosomal particles. Involved in the regulation of TY1 transposition., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4G5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0035361 Cul8-RING ubiquitin ligase complex", "go_biological_process": "GO:0070651 nonfunctional rRNA decay;GO:0051301 cell division;GO:0006275 regulation of DNA replication;GO:0006334 nucleosome assembly;GO:0000725 recombinational repair", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q06211-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06263-1", "uniprot_id": [ { "id": "VTA1_YEAST", "url": "https://www.uniprot.org/uniprot/Q06263", "type": "external" } ], "mass": 37316.0, "length": 330, "protein_name": "Vacuolar protein sorting-associated protein VTA1", "gene_name": "VTA1", "organism": "Yeast", "refseq_name": "Vta1p", "refseq_ac": [ { "id": "NP_013282", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013282", "type": "external" } ], "gene_names_uniprotkb": "VTA1", "gene_names_refseq": "VTA1", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein VTA1; VPS20-associated protein 1", "protein_names_refseq": "Vta1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR181C)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "12953057;14562095;14562106;14701806;15086794;16505166;16601096;18032584;18194651;18194652;18280501;18407956;19779198;19795423;19823750;21126336;21177495;22218487;23749301;24374639;32597660;3316224;33481703;33491328;9169871", "class_list": "", "function": "Has a role in the formation of the multivesicular body (MVB). Required for the sorting of lipids to form intralumenal vesicles and for fluid-phase transport to the vacuole. Required for sorting the plasma membrane proteins STE2 and STE3 into the MVB. Acts a cofactor of VSP4, promotes the oligomerization of VPS4 and stimulates its ATPase activity by 6- to 8-fold., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYI5;Q07057", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005768 endosome;GO:0005771 multivesicular body;GO:1990621 ESCRT IV complex", "go_biological_process": "GO:0006869 lipid transport;GO:0015031 protein transport;GO:0045324 late endosome to vacuole transport;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q06263-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06337-1", "uniprot_id": [ { "id": "EAF1_YEAST", "url": "https://www.uniprot.org/uniprot/Q06337", "type": "external" } ], "mass": 112502.0, "length": 982, "protein_name": "Chromatin modification-related protein EAF1", "gene_name": "EAF1", "organism": "Yeast", "refseq_name": "Eaf1p", "refseq_ac": [ { "id": "NP_010646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010646", "type": "external" } ], "gene_names_uniprotkb": "EAF1; VID21", "gene_names_refseq": "EAF1; VID21", "protein_names_uniprotkb": "Chromatin modification-related protein EAF1; ESA1-associated factor 1; Vacuolar import and degradation protein 21", "protein_names_refseq": "Eaf1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR359C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11726929;14690591;15045029;15353583;15485911;18407956;19779198;20489023;20702584;21126336;21177495;23749301;24374639;32597660;33229814;33481703;33491328;34965436;9169867", "class_list": "", "function": "Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VSY8;Q6S6F6", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035267 NuA4 histone acetyltransferase complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization;GO:0036228 protein localization to nuclear inner membrane;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q06337-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06340-1", "uniprot_id": [ { "id": "ESC2_YEAST", "url": "https://www.uniprot.org/uniprot/Q06340", "type": "external" } ], "mass": 52542.0, "length": 456, "protein_name": "Protein ESC2", "gene_name": "ESC2", "organism": "Yeast", "refseq_name": "Esc2p", "refseq_ac": [ { "id": "NP_010650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010650", "type": "external" } ], "gene_names_uniprotkb": "ESC2", "gene_names_refseq": "ESC2", "protein_names_uniprotkb": "Protein ESC2; Establishes silent chromatin protein 2", "protein_names_refseq": "Esc2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR363W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11090616;12399377;14562095;14562106;15698469;17563356;18407956;19684113;19779198;19795423;19823750;20139071;21725298;23749301;24374639;30516470;32597660;33481703;33491328;9169867", "class_list": "", "function": "May be a substrate targeting component of a cullin-RING-based E3 ubiquitin-protein ligase complex RTT101(MMS1-ESC2). Involved in HMR and telomere silencing via the recruitment or stabilizing of the SIR (silent information regulators) complex., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSZ1", "ec_number_list": [], "go_molecular_function": "GO:0000400 four-way junction DNA binding;GO:0000403 Y-form DNA binding;GO:0070336 flap-structured DNA binding;GO:0180016 SUMO ligase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000724 double-strand break repair via homologous recombination;GO:0032079 positive regulation of endodeoxyribonuclease activity;GO:0033235 positive regulation of protein sumoylation;GO:0031573 mitotic intra-S DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q06340-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06389-1", "uniprot_id": [ { "id": "NCS1_YEAST", "url": "https://www.uniprot.org/uniprot/Q06389", "type": "external" } ], "mass": 22011.0, "length": 190, "protein_name": "Calcium-binding protein NCS-1", "gene_name": "FRQ1", "organism": "Yeast", "refseq_name": "frequenin", "refseq_ac": [ { "id": "NP_010661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010661", "type": "external" } ], "gene_names_uniprotkb": "FRQ1; D9481.6; NCS1", "gene_names_refseq": "FRQ1", "protein_names_uniprotkb": "Calcium-binding protein NCS-1", "protein_names_refseq": "frequenin", "tax_id": 559292, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); torsion dystonia 2 (Disease Ontology:DOID:0090038); Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (sce:YDR373W); (R-SCE-2514859)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10559922;11015193;14562106;24374639;33491328;9169867", "class_list": "", "function": "Regulator of phosphatidylinositol 4-kinase PIK1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT04", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0098744 1-phosphatidylinositol 4-kinase activator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0016020 membrane;GO:0033101 cellular bud membrane", "go_biological_process": "GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q06389-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06406-1", "uniprot_id": [ { "id": "LSM6_YEAST", "url": "https://www.uniprot.org/uniprot/Q06406", "type": "external" } ], "mass": 9398.0, "length": 86, "protein_name": "LSM complex subunit LSM6", "gene_name": "LSM6", "organism": "Yeast", "refseq_name": "U4/U6-U5 snRNP complex subunit LSM6", "refseq_ac": [ { "id": "NP_010666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010666", "type": "external" } ], "gene_names_uniprotkb": "LSM6; D9481.18", "gene_names_refseq": "LSM6", "protein_names_uniprotkb": "LSM complex subunit LSM6", "protein_names_refseq": "U4/U6-U5 snRNP complex subunit LSM6", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR378C); (R-SCE-430039)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10369684;10428970;10449419;10747033;10761922;12077351;12438310;14627812;15075370;15485930;15905473;17513695;18029398;24139796;24240276;24374639;24513854;29717126;30059503;33481703;33491328;9169867", "class_list": "", "function": "Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner (PubMed:10747033, PubMed:24513854). Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step (PubMed:10747033, PubMed:10761922, PubMed:17513695, PubMed:24513854). Together with PAT1, the LSM1-LSM7 complex binds to osmotic stress-activated mRNAs to attenuate the osmotic stress response, probably by limiting ribosome access to the mRNA and consequently translation (PubMed:30059503). Component of the nuclear LSM2-LSM8 complex, which is involved in spliceosome assembly (PubMed:10747033). The LSM2-LSM8 complex plays a role in the biogenesis of the spliceosomal U4/U6-U5 tri-snRNP complex by accelerating PRP24-mediated annealing of U4/U6 di-snRNA (PubMed:10747033, PubMed:24240276, PubMed:29717126). The LSM2-LSM8 complex binds U6 snRNA terminating with a non-cyclic 3' phosphate group (PubMed:29717126). LSM2-LSM8 is probably also involved in degradation of nuclear pre-mRNA by targeting them for decapping (PubMed:15485930). LSM2-LSM8 could be involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA, although involvement may be indirect (PubMed:12077351, PubMed:12438310, PubMed:15075370). In a complex that probably contains LSM2-LSM7, but not LSM1 or LSM8, associates with the precursor of the RNA component of RNase P (pre-P RNA) and may be involved in maturing pre-P RNA; the complex also associates with snoRNA SNR5 (PubMed:10369684, PubMed:15075370)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT10", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005681 spliceosomal complex;GO:0000932 P-body;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0008033 tRNA processing;GO:0000398 mRNA splicing, via spliceosome;GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q06406-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06410-1", "uniprot_id": [ { "id": "ATG17_YEAST", "url": "https://www.uniprot.org/uniprot/Q06410", "type": "external" } ], "mass": 48656.0, "length": 417, "protein_name": "Autophagy-related protein 17", "gene_name": "ATG17", "organism": "Yeast", "refseq_name": "protein kinase regulatory subunit ATG17", "refseq_ac": [ { "id": "NP_013527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013527", "type": "external" } ], "gene_names_uniprotkb": "ATG17; APG17", "gene_names_refseq": "APG17; ATG17", "protein_names_uniprotkb": "Autophagy-related protein 17", "protein_names_refseq": "protein kinase regulatory subunit ATG17", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR423C)", "pathway_count": 1, "publication_count": 37, "publication_id_list": "10995454;11486014;11489916;12048214;14536056;14562095;14562106;15659643;15743910;15901835;17287358;17362880;17700056;18077553;18287526;18298591;18625846;18701704;19061865;19223769;19371383;19755117;19779198;19805182;19995911;20065092;20439775;20729555;21703229;21712380;22768199;22778255;22885598;23169651;24374639;30655342;9169871", "class_list": "", "function": "Autophagy-specific protein that functions with ATG13, ATG29, and CIS1/ATG31 in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles, through interacting with and regulating ATG1 kinase activity. Plays particularly a role in pexophagy and nucleophagy. With ATG13, is required for ATG1 activation by autophosphorylation of 'Thr-226'. Recruits ATG9 to the pre-autophagosomal structure. Also plays a role in regulation of filamentous growth., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ59", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0030295 protein kinase activator activity;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site;GO:1990316 Atg1/ULK1 kinase complex", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0042594 response to starvation;GO:0006914 autophagy;GO:0034497 protein localization to phagophore assembly site;GO:0000422 autophagy of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q06410-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06411-1", "uniprot_id": [ { "id": "SP382_YEAST", "url": "https://www.uniprot.org/uniprot/Q06411", "type": "external" } ], "mass": 83049.0, "length": 708, "protein_name": "Pre-mRNA-splicing factor SPP382", "gene_name": "SPP382", "organism": "Yeast", "refseq_name": "mRNA splicing protein SPP382", "refseq_ac": [ { "id": "NP_013528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013528", "type": "external" } ], "gene_names_uniprotkb": "SPP382; CCF8; NTR1", "gene_names_refseq": "CCF8; NTR1; SPP382", "protein_names_uniprotkb": "Pre-mRNA-splicing factor SPP382; CLF1 complex factor 8; NTC-related protein 1; Nineteen complex-related protein 1; Suppressor of PRP38 protein 2", "protein_names_refseq": "mRNA splicing protein SPP382", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR424W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12509417;14562095;14562106;14690591;16357217;16880513;23749301;24374639;33491328;9169871", "class_list": "", "function": "Involved in pre-mRNA splicing and spliceosome disassembly. Promotes release of excised lariat intron from the spliceosome by acting as a receptor for PRP43. This targeting of PRP43 leads to disassembly of the spliceosome with the separation of the U2, U5, U6 snRNPs and the NTC complex., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ60", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0071008 U2-type post-mRNA release spliceosomal complex", "go_biological_process": "GO:0000349 generation of catalytic spliceosome for first transesterification step;GO:0000390 spliceosomal complex disassembly;GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q06411-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06412-1", "uniprot_id": [ { "id": "TUS1_YEAST", "url": "https://www.uniprot.org/uniprot/Q06412", "type": "external" } ], "mass": 149113.0, "length": 1307, "protein_name": "Rho1 guanine nucleotide exchange factor TUS1", "gene_name": "TUS1", "organism": "Yeast", "refseq_name": "Rho family guanine nucleotide exchange factor TUS1", "refseq_ac": [ { "id": "NP_013529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013529", "type": "external" } ], "gene_names_uniprotkb": "TUS1; SOP10", "gene_names_refseq": "SOP10; TUS1", "protein_names_uniprotkb": "Rho1 guanine nucleotide exchange factor TUS1; TOR unique function suppressor protein 1", "protein_names_refseq": "Rho family guanine nucleotide exchange factor TUS1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR425W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11839800;17563356;18407956;19779198;19795423;19823750;21177495;23749301;24374639;32597660;33481703;33491328;9169871", "class_list": "", "function": "Guanine nucleotide-exchange factor (GEF) for RHO1 that stimulates the exchange of RHO1 GDP-bound form into GTP-bound form. Required for signaling of cell wall defects to RHO1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ61", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0071944 cell periphery;GO:0032153 cell division site;GO:0000131 incipient cellular bud site;GO:0005935 cellular bud neck", "go_biological_process": "GO:0007165 signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0031505 fungal-type cell wall organization;GO:1903338 regulation of cell wall organization or biogenesis;GO:1903501 positive regulation of mitotic actomyosin contractile ring assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q06412-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06449-1", "uniprot_id": [ { "id": "PIN3_YEAST", "url": "https://www.uniprot.org/uniprot/Q06449", "type": "external" } ], "mass": 23539.0, "length": 215, "protein_name": "[PSI+] inducibility protein 3", "gene_name": "PIN3", "organism": "Yeast", "refseq_name": "Pin3p", "refseq_ac": [ { "id": "NP_015480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015480", "type": "external" } ], "gene_names_uniprotkb": "PIN3; LSB2", "gene_names_refseq": "LSB2; PIN3", "protein_names_uniprotkb": "[PSI+] inducibility protein 3; LAS seventeen-binding protein 2; LAS17-binding protein 2", "protein_names_refseq": "Pin3p", "tax_id": 559292, "disease": "prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); prostate adenocarcinoma (Disease Ontology:DOID:2526); endometrial carcinoma (Disease Ontology:DOID:2871)", "pathway": " (sce:YPR154W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10512884;11511345;12872131;14562095;14562106;17322287;17563356;19779198;21777813;22000681;22106047;22218487;22814378;23749301;24374639;33491328;9169875", "class_list": "", "function": "Overproduction promotes the de novo induction of the [PSI+] prion form of SUP35. The prion-inducing effect depends on the association with the actin cytoskeleton. Also implicated in prion maintenance during heat stress., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4F0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030479 actin cortical patch", "go_biological_process": "GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q06449-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06479-1", "uniprot_id": [ { "id": "YL352_YEAST", "url": "https://www.uniprot.org/uniprot/Q06479", "type": "external" } ], "mass": 93123.0, "length": 807, "protein_name": "F-box protein YLR352W", "gene_name": "", "organism": "Yeast", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "F-box protein YLR352W", "protein_names_refseq": "", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR352W); (R-SCE-917937); (R-SCE-983168)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11283612;14562106;19779198;24374639;32597660;33481703;33491328;9169871", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYZ0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q06479-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06506-1", "uniprot_id": [ { "id": "RRP9_YEAST", "url": "https://www.uniprot.org/uniprot/Q06506", "type": "external" } ], "mass": 65054.0, "length": 573, "protein_name": "Ribosomal RNA-processing protein 9", "gene_name": "RRP9", "organism": "Yeast", "refseq_name": "ribosomal RNA-processing protein RRP9", "refseq_ac": [ { "id": "NP_015463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015463", "type": "external" } ], "gene_names_uniprotkb": "RRP9", "gene_names_refseq": "RRP9", "protein_names_uniprotkb": "Ribosomal RNA-processing protein 9", "protein_names_refseq": "ribosomal RNA-processing protein RRP9", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR137W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11105764;12068309;14562095;14562106;18407956;19795423;19823750;20884785;22814378;23749301;24374639;33481703;33491328;9169875", "class_list": "", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA. Required for efficient pre-rRNA cleavage at sites A0, A1 and A2, and biosynthesis of 18S rRNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4D3", "ec_number_list": [], "go_molecular_function": "GO:0030515 snoRNA binding;GO:0034511 U3 snoRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0031428 box C/D methylation guide snoRNP complex;GO:0030686 90S preribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q06506-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06512-1", "uniprot_id": [ { "id": "NOC4_YEAST", "url": "https://www.uniprot.org/uniprot/Q06512", "type": "external" } ], "mass": 63637.0, "length": 552, "protein_name": "Nucleolar complex protein 4", "gene_name": "NOC4", "organism": "Yeast", "refseq_name": "ribosome biosynthesis protein NOC4", "refseq_ac": [ { "id": "NP_015470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015470", "type": "external" } ], "gene_names_uniprotkb": "NOC4; UTP19", "gene_names_refseq": "NOC4; UTP19", "protein_names_uniprotkb": "Nucleolar complex protein 4; U three protein 19; U3 small nucleolar RNA-associated protein 19; U3 snoRNA-associated protein 19", "protein_names_refseq": "ribosome biosynthesis protein NOC4", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR144C); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12446671;14562106;15590835;16159874;22814378;24374639;33491328;9169875", "class_list": "", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm. Its subcellular location and association with pre-40S subunit are unaffected by RPS19 disruptions, suggesting it acts before the ribosomal protein., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4E1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q06512-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06592-1", "uniprot_id": [ { "id": "HPA2_YEAST", "url": "https://www.uniprot.org/uniprot/Q06592", "type": "external" } ], "mass": 18334.0, "length": 156, "protein_name": "Histone acetyltransferase HPA2", "gene_name": "HPA2", "organism": "Yeast", "refseq_name": "histone acetyltransferase", "refseq_ac": [ { "id": "NP_015519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015519", "type": "external" } ], "gene_names_uniprotkb": "HPA2; P9677.12", "gene_names_refseq": "HPA2; KAT10", "protein_names_uniprotkb": "Histone acetyltransferase HPA2; 2.3.1.48", "protein_names_refseq": "histone acetyltransferase", "tax_id": 559292, "disease": "anxiety disorder (Disease Ontology:DOID:2030); mood disorder (Disease Ontology:DOID:3324)", "pathway": " (sce:YPR193C); (R-SCE-351200)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10600387;17322287;23775086;24374639;33491328;9169875", "class_list": "", "function": "N-acetyltransferase that acetylates histone H3 at 'Lys-14' and histone H4 at 'Lys-5' and 'Lys-12'. Also acetylates polyamines like putrescine, spermidine and spermine, and certain other small basic proteins like nuclear HMG proteins., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4J3", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.36", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0042802 identical protein binding;GO:0004059 aralkylamine N-acetyltransferase activity;GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006325 chromatin organization;GO:0006473 protein acetylation;GO:0032917 polyamine acetylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q06592-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06624-1", "uniprot_id": [ { "id": "RHC31_YEAST", "url": "https://www.uniprot.org/uniprot/Q06624", "type": "external" } ], "mass": 39273.0, "length": 347, "protein_name": "DNA damage tolerance protein RHC31", "gene_name": "AOS1", "organism": "Yeast", "refseq_name": "E1 ubiquitin-activating protein AOS1", "refseq_ac": [ { "id": "NP_015506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015506", "type": "external" } ], "gene_names_uniprotkb": "AOS1; P9705.5; RHC31", "gene_names_refseq": "AOS1; RHC31", "protein_names_uniprotkb": "DNA damage tolerance protein RHC31; RAD31 homolog", "protein_names_refseq": "E1 ubiquitin-activating protein AOS1", "tax_id": 559292, "disease": "hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (sce:YPR180W); (R-SCE-3065676); (R-SCE-3065678)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "14562106;15166219;18407956;22814378;23749301;24374639;33491328;33502312;9092625;9169875", "class_list": "", "function": "Could be involved in a ubiquitin-related process important for DNA damage tolerance., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4I0", "ec_number_list": [], "go_molecular_function": "GO:0008641 ubiquitin-like modifier activating enzyme activity", "go_cellular_component": "GO:0031510 SUMO activating enzyme complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016925 protein sumoylation;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q06624-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06628-1", "uniprot_id": [ { "id": "ATG13_YEAST", "url": "https://www.uniprot.org/uniprot/Q06628", "type": "external" } ], "mass": 83281.0, "length": 738, "protein_name": "Autophagy-related protein 13", "gene_name": "ATG13", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase regulatory subunit ATG13", "refseq_ac": [ { "id": "NP_015511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015511", "type": "external" } ], "gene_names_uniprotkb": "ATG13; APG13", "gene_names_refseq": "APG13; ATG13", "protein_names_uniprotkb": "Autophagy-related protein 13", "protein_names_refseq": "serine/threonine protein kinase regulatory subunit ATG13", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR185W); (R-SCE-1632852)", "pathway_count": 2, "publication_count": 64, "publication_id_list": "10837477;10995454;11086004;11486014;14536056;14562095;14562106;14723849;15665377;15743910;15901835;17295840;17330950;17426440;17563356;17699586;18077553;18287526;18407956;18829864;19684113;19755117;19779198;19795423;19805182;19823750;19995911;20383061;20439775;20489023;20647741;20702584;20855505;20953146;21078689;21126336;21177495;21468027;21490424;21712380;21900499;22218487;22447937;22727621;22778255;22782902;22885598;23219485;23749301;24374639;29698392;30516470;30655342;31512555;32025038;32597660;33481703;33491328;33536246;34965436;35363116;8224160;9169875;9224892", "class_list": "", "function": "Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy (PubMed:10995454, PubMed:11086004, PubMed:15743910, PubMed:17295840, PubMed:18077553, PubMed:18287526, PubMed:19805182, PubMed:19995911, PubMed:20647741, PubMed:20855505, PubMed:21468027, PubMed:22447937, PubMed:22778255, PubMed:22782902, PubMed:22885598, PubMed:8224160). Required for autophosphorylation of ATG1 at 'Thr-226' and its dimerization (PubMed:17699586, PubMed:20439775, PubMed:21712380). May also be involved in the regulation of autophagy through SNF1 (PubMed:11486014). Involved in ATG9 and ATG23 cycling through the pre-autophagosomal structure (PubMed:14723849, PubMed:17426440). Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation (PubMed:10837477). Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy (PubMed:10837477, PubMed:31512555). Finally, ATG13 is also required for glycogen storage during stationary phase (PubMed:11486014)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 53, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4I5", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0019887 protein kinase regulator activity;GO:0070016 armadillo repeat domain binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005776 autophagosome;GO:0000407 phagophore assembly site;GO:1990316 Atg1/ULK1 kinase complex;GO:0070772 PAS complex", "go_biological_process": "GO:0060341 regulation of cellular localization;GO:0000045 autophagosome assembly;GO:0042594 response to starvation;GO:0016236 macroautophagy;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 6.5, "record_id": "Q06628-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06639-1", "uniprot_id": [ { "id": "RSC3_YEAST", "url": "https://www.uniprot.org/uniprot/Q06639", "type": "external" } ], "mass": 101720.0, "length": 885, "protein_name": "Chromatin structure-remodeling complex protein RSC3", "gene_name": "RSC3", "organism": "Yeast", "refseq_name": "Rsc3p", "refseq_ac": [ { "id": "NP_010589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010589", "type": "external" } ], "gene_names_uniprotkb": "RSC3; D9740.13", "gene_names_refseq": "RSC3", "protein_names_uniprotkb": "Chromatin structure-remodeling complex protein RSC3; Remodel the structure of chromatin complex subunit 3", "protein_names_refseq": "Rsc3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR303C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10025404;10329629;10619019;11336698;12072455;12183366;12697820;14562106;16204215;17330950;17563356;18407956;19779198;20702584;21177495;23749301;24374639;30516470;32597660;33229814;33481703;33491328;8980231;9169867", "class_list": "", "function": "Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is required for transcription of ribosomal protein genes and genes involved in the integrity of the cell wall, and also for proper metaphase progression. Together with HTL1, LDB7, NPL6, RSC30 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VST2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0016586 RSC-type complex", "go_biological_process": "GO:0033262 regulation of nuclear cell cycle DNA replication;GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q06639-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06640-1", "uniprot_id": [ { "id": "YD306_YEAST", "url": "https://www.uniprot.org/uniprot/Q06640", "type": "external" } ], "mass": 54437.0, "length": 478, "protein_name": "F-box protein YDR306C", "gene_name": "", "organism": "Yeast", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "F-box protein YDR306C", "protein_names_refseq": "", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR306C); (R-SCE-917937); (R-SCE-983168)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "14747994;24374639;33491328;9169867", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VST5", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q06640-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06679-1", "uniprot_id": [ { "id": "UTP4_YEAST", "url": "https://www.uniprot.org/uniprot/Q06679", "type": "external" } ], "mass": 87801.0, "length": 776, "protein_name": "U3 small nucleolar RNA-associated protein 4", "gene_name": "UTP4", "organism": "Yeast", "refseq_name": "small subunit rRNA maturation protein UTP4", "refseq_ac": [ { "id": "NP_010611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010611", "type": "external" } ], "gene_names_uniprotkb": "UTP4", "gene_names_refseq": "UTP4", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 4; U three protein 4; U3 protein 4 required for transcription; U3 snoRNA-associated protein 4; t-UTP4", "protein_names_refseq": "small subunit rRNA maturation protein UTP4", "tax_id": 559292, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); cholestasis (Disease Ontology:DOID:13580); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (sce:YDR324C); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12068309;14562106;15489292;21177495;24374639;9169867", "class_list": "", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSV7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0034455 t-UTP complex;GO:0030686 90S preribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q06679-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06680-1", "uniprot_id": [ { "id": "CND3_YEAST", "url": "https://www.uniprot.org/uniprot/Q06680", "type": "external" } ], "mass": 117851.0, "length": 1035, "protein_name": "Condensin complex subunit 3", "gene_name": "YCG1", "organism": "Yeast", "refseq_name": "condensin subunit YCG1", "refseq_ac": [ { "id": "NP_010612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010612", "type": "external" } ], "gene_names_uniprotkb": "YCG1; YCS5", "gene_names_refseq": "TIE1; YCG1; YCS5", "protein_names_uniprotkb": "Condensin complex subunit 3; CAPG homolog", "protein_names_refseq": "condensin subunit YCG1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR325W); (R-SCE-2514853)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10811823;14562106;17287358;17330950;17563356;18407956;19481522;19779198;20190278;20702584;23749301;24374639;32597660;33481703;33491328;9169867", "class_list": "", "function": "Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSV8", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000793 condensed chromosome;GO:0000796 condensin complex", "go_biological_process": "GO:0051307 meiotic chromosome separation;GO:0051301 cell division;GO:0007076 mitotic chromosome condensation;GO:0007130 synaptonemal complex assembly;GO:0030261 chromosome condensation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q06680-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07084-1", "uniprot_id": [ { "id": "SSK1_YEAST", "url": "https://www.uniprot.org/uniprot/Q07084", "type": "external" } ], "mass": 78529.0, "length": 712, "protein_name": "Osmolarity two-component system protein SSK1", "gene_name": "SSK1", "organism": "Yeast", "refseq_name": "mitogen-activated protein kinase kinase kinase SSK1", "refseq_ac": [ { "id": "NP_013106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013106", "type": "external" } ], "gene_names_uniprotkb": "SSK1", "gene_names_refseq": "SSK1", "protein_names_uniprotkb": "Osmolarity two-component system protein SSK1", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase SSK1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR006C)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "11073911;12944490;14562106;14665464;15665377;16920868;17287358;17330950;17563356;18407956;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22218487;23749301;24374639;25734609;31642125;32597660;33481703;33491328;8183345;8808622;9169871", "class_list": "", "function": "Final receptor of the SLN1-YPD1-SSK1 two-component regulatory system, which controls activity of the HOG1 pathway in response to changes in the osmolarity of the extracellular environment. Under normal osmotic conditions, maintained in a phosphorylated and inactive state by the phosphorelay intermediate protein YPD1. Under conditions of high osmolarity, the histidine kinase SLN1 is no longer active and the unphosphorylated form of SSK1 interacts with and activates SSK2 and SSK22, two MAPKKKs that further stimulate the PBS2-HOG1 MAPKK-MAPK cascade. Unphosphorylated SSK1 is subsequently degraded by the UBC7-dependent ubiquitin-proteasome system to down-regulate the HOG1 pathway after completion of the osmotic adaptation., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 29, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VY08;Q07909", "ec_number_list": [], "go_molecular_function": "GO:0030295 protein kinase activator activity;GO:0031435 mitogen-activated protein kinase kinase kinase binding;GO:0000156 phosphorelay response regulator activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:1900744 regulation of p38MAPK cascade;GO:0032956 regulation of actin cytoskeleton organization;GO:0071474 cellular hyperosmotic response;GO:0071468 cellular response to acidic pH;GO:0007234 osmosensory signaling via phosphorelay pathway", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q07084-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07528-1", "uniprot_id": [ { "id": "ATG20_YEAST", "url": "https://www.uniprot.org/uniprot/Q07528", "type": "external" } ], "mass": 72546.0, "length": 640, "protein_name": "Autophagy-related protein 20", "gene_name": "ATG20", "organism": "Yeast", "refseq_name": "Atg20p", "refseq_ac": [ { "id": "NP_010170", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010170", "type": "external" } ], "gene_names_uniprotkb": "ATG20; CVT20; SNX42", "gene_names_refseq": "ATG20; CVT20; SNX42", "protein_names_uniprotkb": "Autophagy-related protein 20; Cytoplasm to vacuole targeting protein 20; Sorting nexin-42", "protein_names_refseq": "Atg20p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL113C)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "11875433;12048214;12554655;14536056;14562095;14562106;15659643;15901835;16138904;17132049;17563356;18407956;19684113;19779198;19793921;19795423;19823750;20861302;21177495;22814378;23749301;24374639;30516470;32597660;33481703;33491328;34965436;9169867", "class_list": "", "function": "Required for cytoplasm to vacuole transport (Cvt), pexophagy and mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Functions in protein retrieval from the endocytic pathway. Required for proper sorting of the v-SNARE protein SNC1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRN7", "ec_number_list": [], "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site;GO:0010009 cytoplasmic side of endosome membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016236 macroautophagy;GO:0042147 retrograde transport, endosome to Golgi;GO:0000422 autophagy of mitochondrion;GO:0061709 reticulophagy", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q07528-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07533-1", "uniprot_id": [ { "id": "CYK3_YEAST", "url": "https://www.uniprot.org/uniprot/Q07533", "type": "external" } ], "mass": 100621.0, "length": 885, "protein_name": "Cytokinesis protein 3", "gene_name": "CYK3", "organism": "Yeast", "refseq_name": "Cyk3p", "refseq_ac": [ { "id": "NP_010166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010166", "type": "external" } ], "gene_names_uniprotkb": "CYK3", "gene_names_refseq": "CYK3", "protein_names_uniprotkb": "Cytokinesis protein 3", "protein_names_refseq": "Cyk3p", "tax_id": 559292, "disease": "myofibrillar myopathy 7 (Disease Ontology:DOID:0080098)", "pathway": " (sce:YDL117W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10959846;11875433;14562095;14562106;17287358;17330950;17563356;18407956;19528296;19707790;19779198;19795423;19823750;20702584;21126336;21177495;23749301;24374639;32597660;33481703;33491328;9169867", "class_list": "", "function": "Involved in cytokinesis by recruiting INN1 to the bud neck. Cooperates with INN1 to stimulate the synthesis of the primary septum (PS) by CHS2., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRN3", "ec_number_list": [], "go_molecular_function": "GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0044697 HICS complex;GO:0000142 cellular bud neck contractile ring", "go_biological_process": "GO:1902410 mitotic cytokinetic process;GO:0140278 mitotic division septum assembly;GO:1990344 secondary cell septum biogenesis", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q07533-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07540-1", "uniprot_id": [ { "id": "FRDA_YEAST", "url": "https://www.uniprot.org/uniprot/Q07540", "type": "external" } ], "mass": 19490.0, "length": 174, "protein_name": "Frataxin homolog, mitochondrial", "gene_name": "YFH1", "organism": "Yeast", "refseq_name": "ferroxidase", "refseq_ac": [ { "id": "NP_010163", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010163", "type": "external" } ], "gene_names_uniprotkb": "YFH1", "gene_names_refseq": "YFH1", "protein_names_uniprotkb": "Frataxin homolog, mitochondrial; 1.16.3.1", "protein_names_refseq": "ferroxidase", "tax_id": 559292, "disease": "Friedreich ataxia 1 (Disease Ontology:DOID:0111218); Friedreich ataxia (Disease Ontology:DOID:12705); cancer (Disease Ontology:DOID:162); iron metabolism disease (Disease Ontology:DOID:2351); glioblastoma (Disease Ontology:DOID:3068); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YDL120W); (R-SCE-1268020); (R-SCE-1362409); (R-SCE-9854311); (R-SCE-9865881)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "10428860;10545606;10588895;12947415;14562106;15961414;16371422;17027502;17322287;18319250;18393441;19884169;24374639;26941001;28548666;33491328;9169867;9180083;9988680", "class_list": "", "function": "Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. May be involved in regulation of the mitochondrial electron transport chain., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRN0", "ec_number_list": [ { "id": "2.1.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.3", "type": "external" }, { "id": "7.1.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.8", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.24.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.64", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "2.8.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.7", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0008198 ferrous iron binding;GO:0004322 ferroxidase activity;GO:0034986 iron chaperone activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006979 response to oxidative stress;GO:0006879 intracellular iron ion homeostasis;GO:0010040 response to iron(II) ion;GO:0006783 heme biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q07540-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07549-1", "uniprot_id": [ { "id": "SNA4_YEAST", "url": "https://www.uniprot.org/uniprot/Q07549", "type": "external" } ], "mass": 15673.0, "length": 140, "protein_name": "Protein SNA4", "gene_name": "SNA4", "organism": "Yeast", "refseq_name": "Sna4p", "refseq_ac": [ { "id": "NP_010160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010160", "type": "external" } ], "gene_names_uniprotkb": "SNA4", "gene_names_refseq": "SNA4", "protein_names_uniprotkb": "Protein SNA4", "protein_names_refseq": "Sna4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL123W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11566881;14562095;14562106;15665377;16107716;16751107;16847258;17322287;19795423;19823750;21126336;22106047;23749301;24374639;32597660;33481703;33491328;9169867", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRM7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000329 fungal-type vacuole membrane;GO:0000328 fungal-type vacuole lumen", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q07549-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07622-1", "uniprot_id": [ { "id": "ACK1_YEAST", "url": "https://www.uniprot.org/uniprot/Q07622", "type": "external" } ], "mass": 69371.0, "length": 623, "protein_name": "Activator of C kinase protein 1", "gene_name": "ACK1", "organism": "Yeast", "refseq_name": "Ack1p", "refseq_ac": [ { "id": "NP_010078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010078", "type": "external" } ], "gene_names_uniprotkb": "ACK1; D1066", "gene_names_refseq": "ACK1", "protein_names_uniprotkb": "Activator of C kinase protein 1", "protein_names_refseq": "Ack1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL203C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12872131;14562106;17563356;18407956;19795423;19823750;22106047;22344253;23749301;24374639;32597660;33481703;33491328;9046097;9169867", "class_list": "", "function": "Functions in the cell wall integrity pathway and is required for the proper localization of the RHO1 GDP-GTP exchange protein ROM2., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRF1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0009967 positive regulation of signal transduction;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q07622-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07688-1", "uniprot_id": [ { "id": "YPD1_YEAST", "url": "https://www.uniprot.org/uniprot/Q07688", "type": "external" } ], "mass": 19169.0, "length": 167, "protein_name": "Phosphorelay intermediate protein YPD1", "gene_name": "YPD1", "organism": "Yeast", "refseq_name": "Ypd1p", "refseq_ac": [ { "id": "NP_010046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010046", "type": "external" } ], "gene_names_uniprotkb": "YPD1; D0790", "gene_names_refseq": "YPD1", "protein_names_uniprotkb": "Phosphorelay intermediate protein YPD1; Histidine-containing phosphotransfer protein YPD1; Tyrosine phosphatase-dependent protein 1", "protein_names_refseq": "Ypd1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL235C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10512701;10543964;11073911;14562095;14562106;14656441;14665464;15015733;15628880;24374639;33481703;33491328;8808622;9169867;9843501", "class_list": "", "function": "Phosphorelay intermediate protein that is part of the branched SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to changes in the osmolarity of the extracellular environment. Catalyzes the phosphoryl group transfer from the membrane-bound osmosensing histidine kinase SLN1 to two distinct response regulator proteins, SSK1 in the cytoplasm, and transcription factor SKN7 in the nucleus., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRC1", "ec_number_list": [], "go_molecular_function": "GO:0016772 transferase activity, transferring phosphorus-containing groups;GO:0043424 protein histidine kinase binding;GO:0009927 histidine phosphotransfer kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000160 phosphorelay signal transduction system;GO:0007234 osmosensory signaling via phosphorelay pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q07688-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07748-1", "uniprot_id": [ { "id": "THI13_YEAST", "url": "https://www.uniprot.org/uniprot/Q07748", "type": "external" } ], "mass": 38574.0, "length": 340, "protein_name": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI13", "gene_name": "THI13", "organism": "Yeast", "refseq_name": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase", "refseq_ac": [ { "id": "NP_010037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010037", "type": "external" } ], "gene_names_uniprotkb": "THI13", "gene_names_refseq": "THI13", "protein_names_uniprotkb": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI13; 2.-.-.-; HMP-P synthase; Hydroxymethylpyrimidine phosphate synthase; Thiamine biosynthesis protein 13; Thiamine pyrimidine synthase", "protein_names_refseq": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL244W)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12777485;24374639;9169867", "class_list": "", "function": "Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRB3", "ec_number_list": [ { "id": "2.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0106344 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP", "go_cellular_component": "", "go_biological_process": "GO:0009229 thiamine diphosphate biosynthetic process;GO:0009228 thiamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q07748-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07821-1", "uniprot_id": [ { "id": "ISA1_YEAST", "url": "https://www.uniprot.org/uniprot/Q07821", "type": "external" } ], "mass": 27675.0, "length": 250, "protein_name": "Iron-sulfur assembly protein 1", "gene_name": "ISA1", "organism": "Yeast", "refseq_name": "Fe-binding Fe/S cluster assembly protein ISA1", "refseq_ac": [ { "id": "NP_013073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013073", "type": "external" } ], "gene_names_uniprotkb": "ISA1", "gene_names_refseq": "ISA1", "protein_names_uniprotkb": "Iron-sulfur assembly protein 1", "protein_names_refseq": "Fe-binding Fe/S cluster assembly protein ISA1", "tax_id": 559292, "disease": "multiple mitochondrial dysfunctions syndrome 5 (Disease Ontology:DOID:0080274)", "pathway": " (sce:YLL027W); (R-SCE-1362409)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10748136;14562106;24374639;9169871", "class_list": "", "function": "Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXX7", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0051536 iron-sulfur cluster binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0051604 protein maturation;GO:0044572 [4Fe-4S] cluster assembly;GO:0009102 biotin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q07821-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07879-1", "uniprot_id": [ { "id": "ATG10_YEAST", "url": "https://www.uniprot.org/uniprot/Q07879", "type": "external" } ], "mass": 19760.0, "length": 167, "protein_name": "Ubiquitin-like-conjugating enzyme ATG10", "gene_name": "ATG10", "organism": "Yeast", "refseq_name": "E2-like conjugating enzyme", "refseq_ac": [ { "id": "NP_013058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013058", "type": "external" } ], "gene_names_uniprotkb": "ATG10; APG10", "gene_names_refseq": "APG10; ATG10", "protein_names_uniprotkb": "Ubiquitin-like-conjugating enzyme ATG10; 2.3.2.-; Autophagy-related protein 10", "protein_names_refseq": "E2-like conjugating enzyme", "tax_id": 559292, "disease": "", "pathway": " (sce:YLL042C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10508157;11689437;14536056;16874032;17295840;17565192;18701704;18725539;21193819;22056771;22768199;22993095;23142976;24374639;8224160;9169871;9759731", "class_list": "", "function": "E2-like enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy and nucleophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for proper localization of ATG8 to the preautophagosomal structure (PAS). Likely serves as an ATG5-recognition molecule., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXW4", "ec_number_list": [], "go_molecular_function": "GO:0019777 Atg12 transferase activity", "go_cellular_component": "GO:0034045 phagophore assembly site membrane", "go_biological_process": "GO:0016236 macroautophagy;GO:0000422 autophagy of mitochondrion;GO:0044804 nucleophagy;GO:0032446 protein modification by small protein conjugation;GO:0034727 piecemeal microautophagy of the nucleus", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q07879-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07921-1", "uniprot_id": [ { "id": "TEN1_YEAST", "url": "https://www.uniprot.org/uniprot/Q07921", "type": "external" } ], "mass": 18605.0, "length": 160, "protein_name": "Telomere length regulation protein TEN1", "gene_name": "TEN1", "organism": "Yeast", "refseq_name": "Ten1p", "refseq_ac": [ { "id": "NP_013110", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013110", "type": "external" } ], "gene_names_uniprotkb": "TEN1", "gene_names_refseq": "TEN1", "protein_names_uniprotkb": "Telomere length regulation protein TEN1; Protein telomeric pathways with STN1", "protein_names_refseq": "Ten1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR010C)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11230140;17322287;24374639;9169871", "class_list": "", "function": "Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY12", "ec_number_list": [], "go_molecular_function": "GO:0043047 single-stranded telomeric DNA binding;GO:0061770 translation elongation factor binding;GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0000781 chromosome, telomeric region;GO:1990879 CST complex", "go_biological_process": "GO:0032205 negative regulation of telomere maintenance;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016233 telomere capping;GO:0032210 regulation of telomere maintenance via telomerase;GO:0007004 telomere maintenance via telomerase", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q07921-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07930-1", "uniprot_id": [ { "id": "PML1_YEAST", "url": "https://www.uniprot.org/uniprot/Q07930", "type": "external" } ], "mass": 23654.0, "length": 204, "protein_name": "Pre-mRNA leakage protein 1", "gene_name": "PML1", "organism": "Yeast", "refseq_name": "Pml1p", "refseq_ac": [ { "id": "NP_013116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013116", "type": "external" } ], "gene_names_uniprotkb": "PML1; L1591", "gene_names_refseq": "PML1", "protein_names_uniprotkb": "Pre-mRNA leakage protein 1", "protein_names_refseq": "Pml1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR016C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562095;14562106;15565172;16618970;17322287;19010333;19033360;24374639;25218446;26212312;27445306;27562955;29794219;33243853;9169871", "class_list": "", "function": "Required for pre-mRNA splicing and spliceosome assembly. As part of the pre-mRNA retention and splicing (RES) complex, required for efficient splicing and nuclear retention of not properly spliced pre-mRNA (PubMed:15565172). Indirectly involved in positioning the proximal bud pole signal by regulating the splicing of the MATa1 pre-mRNA, which encodes a repressor that normally blocks expression of haploid-specific genes in diploid cells. When Mata1 protein is lacking, Axl1, a haploid-specific protein critical for the choice between axial and bipolar budding, is expressed ectopically in diploid cells and disrupts bipolar budding (PubMed:15565172)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY18;Q06901", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0070274 RES complex", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0000398 mRNA splicing, via spliceosome;GO:1903241 U2-type prespliceosome assembly;GO:0051237 maintenance of RNA location", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q07930-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07980-1", "uniprot_id": [ { "id": "MLH2_YEAST", "url": "https://www.uniprot.org/uniprot/Q07980", "type": "external" } ], "mass": 78248.0, "length": 695, "protein_name": "DNA mismatch repair protein MLH2", "gene_name": "MLH2", "organism": "Yeast", "refseq_name": "mismatch repair protein MLH2", "refseq_ac": [ { "id": "NP_013135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013135", "type": "external" } ], "gene_names_uniprotkb": "MLH2", "gene_names_refseq": "MLH2", "protein_names_uniprotkb": "DNA mismatch repair protein MLH2; MutL protein homolog 2", "protein_names_refseq": "mismatch repair protein MLH2", "tax_id": 559292, "disease": "polymyositis (Disease Ontology:DOID:0080745); dermatomyositis (Disease Ontology:DOID:10223); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); Lynch syndrome (Disease Ontology:DOID:3883)", "pathway": " (sce:YLR035C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10570173;10679328;14562095;14562106;15467363;22031224;24374639;33491328;9169871", "class_list": "", "function": "Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of a MutL heterodimer with MLH1, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Plays a role in the repair of heteroduplex sites present in meiotic recombination intermediates and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY37", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0030983 mismatched DNA binding;GO:0140664 ATP-dependent DNA damage sensor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0032389 MutLalpha complex;GO:0032390 MutLbeta complex", "go_biological_process": "GO:0000710 meiotic mismatch repair;GO:0006298 mismatch repair;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q07980-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08162-1", "uniprot_id": [ { "id": "RRP44_YEAST", "url": "https://www.uniprot.org/uniprot/Q08162", "type": "external" } ], "mass": 113707.0, "length": 1001, "protein_name": "Exosome complex exonuclease DIS3", "gene_name": "DIS3", "organism": "Yeast", "refseq_name": "exosome catalytic subunit DIS3", "refseq_ac": [ { "id": "NP_014621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014621", "type": "external" } ], "gene_names_uniprotkb": "DIS3; O2197; RRP44", "gene_names_refseq": "DIS3; MTR17; RRP44", "protein_names_uniprotkb": "Exosome complex exonuclease DIS3; 3.1.13.-; 3.1.26.-; Chromosome disjunction protein 3; Ribosomal RNA-processing protein 44", "protein_names_refseq": "exosome catalytic subunit DIS3", "tax_id": 559292, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (sce:YOL021C); (R-SCE-429958); (R-SCE-450385); (R-SCE-450513)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10465791;14562095;14562106;14576278;17173052;17174896;18374646;19060898;19879841;24374639;30181345;33481703;33491328;8896453;9169874;9390555", "class_list": "", "function": "Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. DIS3 has both 3'-5' exonuclease and endonuclease activities. The exonuclease activity of DIS3 is down-regulated upon association with Exo-9 possibly involving a conformational change in the catalytic domain and threading of the RNA substrate through the complex central channel. Structured substrates can be degraded if they have a 3' single-stranded extension sufficiently long (such as 35 nt poly(A)) to span the proposed complex inner RNA-binding path and to reach the exonuclease site provided by DIS3. Plays a role in mitotic control., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W244", "ec_number_list": [ { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" } ], "go_molecular_function": "GO:0000049 tRNA binding;GO:0004519 endonuclease activity;GO:0004521 RNA endonuclease activity;GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0000176 nuclear exosome (RNase complex);GO:0000177 cytoplasmic exosome (RNase complex)", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0070651 nonfunctional rRNA decay;GO:0006396 RNA processing;GO:0006397 mRNA processing;GO:0016075 rRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q08162-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08204-1", "uniprot_id": [ { "id": "SMC5_YEAST", "url": "https://www.uniprot.org/uniprot/Q08204", "type": "external" } ], "mass": 126037.0, "length": 1093, "protein_name": "Structural maintenance of chromosomes protein 5", "gene_name": "SMC5", "organism": "Yeast", "refseq_name": "DNA repair ATPase SMC5", "refseq_ac": [ { "id": "NP_014608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014608", "type": "external" } ], "gene_names_uniprotkb": "SMC5", "gene_names_refseq": "SMC5", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 5", "protein_names_refseq": "DNA repair ATPase SMC5", "tax_id": 559292, "disease": "mosaic variegated aneuploidy syndrome (Disease Ontology:DOID:0080688)", "pathway": " (sce:YOL034W); (R-SCE-3108214)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14562106;14690591;15738391;24374639;33481703;33491328;9169874", "class_list": "", "function": "Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W231", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003684 damaged DNA binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000781 chromosome, telomeric region;GO:0030915 Smc5-Smc6 complex", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0006281 DNA repair;GO:0000724 double-strand break repair via homologous recombination;GO:0051304 chromosome separation;GO:0000725 recombinational repair", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q08204-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08214-1", "uniprot_id": [ { "id": "NTH2_YEAST", "url": "https://www.uniprot.org/uniprot/Q08214", "type": "external" } ], "mass": 43844.0, "length": 380, "protein_name": "Endonuclease III homolog 2", "gene_name": "NTG2", "organism": "Yeast", "refseq_name": "bifunctional N-glycosylase/AP lyase NTG2", "refseq_ac": [ { "id": "NP_014599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014599", "type": "external" } ], "gene_names_uniprotkb": "NTG2; SCR2", "gene_names_refseq": "NTG2; SCR2", "protein_names_uniprotkb": "Endonuclease III homolog 2; 3.2.2.-; 4.2.99.18; Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 2; DNA glycosylase/AP lyase 2; Endonuclease III-like glycosylase 2; Redoxyendonuclease 2", "protein_names_refseq": "bifunctional N-glycosylase/AP lyase NTG2", "tax_id": 559292, "disease": "familial adenomatous polyposis 3 (Disease Ontology:DOID:0080411)", "pathway": " (sce:YOL043C); (R-SCE-110329)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10207101;10471279;11478780;12042306;14500818;14562106;14697759;15449310;18983898;19029246;24374639;9020769;9169874;9558341;9826748", "class_list": "", "function": "Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines, but also purine-derived lesions, alkylation damage as well as abasic sites. Can also repair the oxidation products of 8-oxoguanine., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W223", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006284 base-excision repair;GO:0006289 nucleotide-excision repair;GO:0006285 base-excision repair, AP site formation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q08214-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08278-1", "uniprot_id": [ { "id": "MED7_YEAST", "url": "https://www.uniprot.org/uniprot/Q08278", "type": "external" } ], "mass": 25585.0, "length": 222, "protein_name": "Mediator of RNA polymerase II transcription subunit 7", "gene_name": "MED7", "organism": "Yeast", "refseq_name": "mediator complex subunit MED7", "refseq_ac": [ { "id": "NP_014506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014506", "type": "external" } ], "gene_names_uniprotkb": "MED7", "gene_names_refseq": "MED7", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 7; Mediator complex subunit 7", "protein_names_refseq": "mediator complex subunit MED7", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL135C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "11555651;12191485;14562095;14562106;14623974;15175151;15477388;15710619;16002404;16076843;16263706;16630888;17192271;17322287;19795423;19823750;23749301;24374639;32597660;33481703;33491328;8896270;9169874;9420330", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1T4", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q08278-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08285-1", "uniprot_id": [ { "id": "RRP40_YEAST", "url": "https://www.uniprot.org/uniprot/Q08285", "type": "external" } ], "mass": 26556.0, "length": 240, "protein_name": "Exosome complex component RRP40", "gene_name": "RRP40", "organism": "Yeast", "refseq_name": "exosome non-catalytic core subunit RRP40", "refseq_ac": [ { "id": "NP_014499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014499", "type": "external" } ], "gene_names_uniprotkb": "RRP40", "gene_names_refseq": "MTR14; RRP40", "protein_names_uniprotkb": "Exosome complex component RRP40; Ribosomal RNA-processing protein 40", "protein_names_refseq": "exosome non-catalytic core subunit RRP40", "tax_id": 559292, "disease": "pontocerebellar hypoplasia type 1B (Disease Ontology:DOID:0060266); stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (sce:YOL142W); (R-SCE-429958); (R-SCE-450385); (R-SCE-450513); (R-SCE-6791226)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10465791;14562095;14562106;17173052;17174896;17322287;18407956;19060898;24374639;33491328;9169874", "class_list": "", "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP40 as peripheral part of the Exo-9 complex is thought to stabilize the hexameric ring of RNase PH-domain subunits., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W1S7;E9P8Z4", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0030145 manganese ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000176 nuclear exosome (RNase complex);GO:0000177 cytoplasmic exosome (RNase complex)", "go_biological_process": "GO:0006396 RNA processing;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0006401 RNA catabolic process;GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0034475 U4 snRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q08285-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08457-1", "uniprot_id": [ { "id": "SLD7_YEAST", "url": "https://www.uniprot.org/uniprot/Q08457", "type": "external" } ], "mass": 29557.0, "length": 257, "protein_name": "Mitochondrial morphogenesis protein SLD7", "gene_name": "SLD7", "organism": "Yeast", "refseq_name": "Sld7p", "refseq_ac": [ { "id": "NP_014703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014703", "type": "external" } ], "gene_names_uniprotkb": "SLD7; YOR29-11", "gene_names_refseq": "SLD7; YOR29-11", "protein_names_uniprotkb": "Mitochondrial morphogenesis protein SLD7; Synthetic lethality with DPB11-24 mutation protein 7", "protein_names_refseq": "Sld7p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR060C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562095;14562106;16135527;21487389;24374639;9133743;9169874", "class_list": "", "function": "Required for the proper function of SLD3 at the initiation of DNA replication. Binds to SLD3 and reduces its affinity for CDC45, a component of the replication fork. Required for mitochondrial morphology., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2C3;O00023", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031261 DNA replication preinitiation complex;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q08457-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08683-1", "uniprot_id": [ { "id": "APC5_YEAST", "url": "https://www.uniprot.org/uniprot/Q08683", "type": "external" } ], "mass": 79275.0, "length": 685, "protein_name": "Anaphase-promoting complex subunit 5", "gene_name": "APC5", "organism": "Yeast", "refseq_name": "anaphase promoting complex subunit 5", "refseq_ac": [ { "id": "NP_014892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014892", "type": "external" } ], "gene_names_uniprotkb": "APC5; RMC1", "gene_names_refseq": "APC5; RMC1", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 5", "protein_names_refseq": "anaphase promoting complex subunit 5", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR249C); (R-SCE-983168)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12609981;14562095;14562106;24374639;9153759;9169874;9469814", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2V0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle;GO:0016567 protein ubiquitination;GO:0006325 chromatin organization;GO:0031145 anaphase-promoting complex-dependent catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q08683-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08685-1", "uniprot_id": [ { "id": "CLP1_YEAST", "url": "https://www.uniprot.org/uniprot/Q08685", "type": "external" } ], "mass": 50226.0, "length": 445, "protein_name": "mRNA cleavage and polyadenylation factor CLP1", "gene_name": "CLP1", "organism": "Yeast", "refseq_name": "cleavage polyadenylation factor subunit CLP1", "refseq_ac": [ { "id": "NP_014893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014893", "type": "external" } ], "gene_names_uniprotkb": "CLP1", "gene_names_refseq": "CLP1", "protein_names_uniprotkb": "mRNA cleavage and polyadenylation factor CLP1", "protein_names_refseq": "cleavage polyadenylation factor subunit CLP1", "tax_id": 559292, "disease": "pontocerebellar hypoplasia (Disease Ontology:DOID:0060264); pontocerebellar hypoplasia type 10 (Disease Ontology:DOID:0060279)", "pathway": " (sce:YOR250C); (R-SCE-9770562)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11344258;17151076;17322287;18648070;21993299;21993300;22026644;22216186;24374639;33491328;8900210;9153759;9169874;9223284", "class_list": "", "function": "Component of the cleavage factor IA (CF IA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation. Associates with HRB1/CF IB to form the cleavage factor I (CF I) complex. CF I is required for correct positioning of a larger protein complex, the cleavage and polyadenylation factor (CPF) complex, which contains the catalytic subunits executing mRNA cleavage and polyadenylation. CLP1 mediates interactions between CF IA and CPF factors. CLP1 is also involved in maintaining the CF IA interaction with the C-terminal domain of RNA Pol II largest subunit via PCF11, which links pre-mRNA 3'-end processing to transcription termination., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2V1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0051731 polynucleotide 5'-hydroxyl-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005849 mRNA cleavage factor complex", "go_biological_process": "GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q08685-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08723-1", "uniprot_id": [ { "id": "RPN8_YEAST", "url": "https://www.uniprot.org/uniprot/Q08723", "type": "external" } ], "mass": 38313.0, "length": 338, "protein_name": "26S proteasome regulatory subunit RPN8", "gene_name": "RPN8", "organism": "Yeast", "refseq_name": "proteasome regulatory particle lid subunit RPN8", "refseq_ac": [ { "id": "NP_014904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014904", "type": "external" } ], "gene_names_uniprotkb": "RPN8; O5360", "gene_names_refseq": "RPN8", "protein_names_uniprotkb": "26S proteasome regulatory subunit RPN8", "protein_names_refseq": "proteasome regulatory particle lid subunit RPN8", "tax_id": 559292, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); neurodegenerative disease (Disease Ontology:DOID:1289); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (sce:YOR261C); (R-SCE-1236978); (R-SCE-5668541); (R-SCE-5689880); (R-SCE-6798695); (R-SCE-9907900)", "pathway_count": 6, "publication_count": 27, "publication_id_list": "11875433;12504901;14562106;15665377;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20486117;20702584;21126336;21177495;22218487;22927375;23749301;24374639;30181345;32597660;33481703;33491328;9153759;9169874;9584156", "class_list": "", "function": "Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2W2;Q6Q5I7", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0000502 proteasome complex;GO:0008541 proteasome regulatory particle, lid subcomplex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q08723-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08817-1", "uniprot_id": [ { "id": "SOG2_YEAST", "url": "https://www.uniprot.org/uniprot/Q08817", "type": "external" } ], "mass": 87326.0, "length": 791, "protein_name": "Leucine-rich repeat-containing protein SOG2", "gene_name": "SOG2", "organism": "Yeast", "refseq_name": "Sog2p", "refseq_ac": [ { "id": "NP_014998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014998", "type": "external" } ], "gene_names_uniprotkb": "SOG2", "gene_names_refseq": "SOG2", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein SOG2", "protein_names_refseq": "Sog2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR353C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12972564;14562095;14562106;18407956;19779198;19795423;19823750;20489023;21126336;23749301;24374639;31208443;32597660;33229814;33481703;33491328;9169874", "class_list": "", "function": "Required for proper cell morphogenesis and cell separation after mitosis. Functions in the RAM (regulation of ACE2 activity and cellular morphogenesis) signaling network and is required for proper ACE2 localization and CBK1 kinase activity., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 13, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "D6W348", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000131 incipient cellular bud site;GO:0005933 cellular bud;GO:0043332 mating projection tip", "go_biological_process": "GO:0000920 septum digestion after cytokinesis;GO:0007165 signal transduction;GO:0007118 budding cell apical bud growth", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q08817-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08919-1", "uniprot_id": [ { "id": "TRE1_YEAST", "url": "https://www.uniprot.org/uniprot/Q08919", "type": "external" } ], "mass": 88756.0, "length": 783, "protein_name": "Uncharacterized protein TRE1", "gene_name": "TRE1", "organism": "Yeast", "refseq_name": "Tre1p", "refseq_ac": [ { "id": "NP_015149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015149", "type": "external" } ], "gene_names_uniprotkb": "TRE1", "gene_names_refseq": "TRE1", "protein_names_uniprotkb": "Uncharacterized protein TRE1; Transferrin receptor-like protein 1", "protein_names_refseq": "Tre1p", "tax_id": 559292, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hemochromatosis type 3 (Disease Ontology:DOID:0111030); duodenal ulcer (Disease Ontology:DOID:1724); hemochromatosis (Disease Ontology:DOID:2352); nutrition disease (Disease Ontology:DOID:374); Weissenbacher-Zweymuller syndrome (Disease Ontology:DOID:4258); hepatocellular carcinoma (Disease Ontology:DOID:684); muscular atrophy (Disease Ontology:DOID:767); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (sce:YPL176C); (R-SCE-8963693)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12374868;14562106;17287358;24374639;9169875", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6W3J2", "ec_number_list": [], "go_molecular_function": "GO:0004180 carboxypeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q08919-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08949-1", "uniprot_id": [ { "id": "DDC1_YEAST", "url": "https://www.uniprot.org/uniprot/Q08949", "type": "external" } ], "mass": 69694.0, "length": 612, "protein_name": "DNA damage checkpoint protein 1", "gene_name": "DDC1", "organism": "Yeast", "refseq_name": "Ddc1p", "refseq_ac": [ { "id": "NP_015130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015130", "type": "external" } ], "gene_names_uniprotkb": "DDC1", "gene_names_refseq": "DDC1", "protein_names_uniprotkb": "DNA damage checkpoint protein 1", "protein_names_refseq": "Ddc1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL194W); (R-SCE-176187)", "pathway_count": 2, "publication_count": 27, "publication_id_list": "10562568;11825877;11973288;12271137;12604797;12672803;14562095;14562106;14574415;15014082;16137930;16169844;16202664;17287358;18407956;18541674;19779198;20005839;23749301;24374639;32597660;33481703;33491328;9169875;9311982;9670034;9891048", "class_list": "", "function": "Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. Associates with sites of DNA damage and modulates the MEC1 signaling pathway and the activation of RAD53 in response to DNA damage at phase G1. The complex also physically regulates DNA polymerase zeta-dependent mutagenesis by controlling the access of polymerase zeta to damaged DNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3H4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030896 checkpoint clamp complex", "go_biological_process": "GO:0051598 meiotic recombination checkpoint signaling;GO:0000076 DNA replication checkpoint signaling;GO:0006281 DNA repair;GO:0071479 cellular response to ionizing radiation;GO:0031573 mitotic intra-S DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q08949-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08955-1", "uniprot_id": [ { "id": "CSM4_YEAST", "url": "https://www.uniprot.org/uniprot/Q08955", "type": "external" } ], "mass": 18307.0, "length": 156, "protein_name": "Chromosome segregation in meiosis protein 4", "gene_name": "CSM4", "organism": "Yeast", "refseq_name": "Csm4p", "refseq_ac": [ { "id": "NP_015124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015124", "type": "external" } ], "gene_names_uniprotkb": "CSM4", "gene_names_refseq": "CSM4", "protein_names_uniprotkb": "Chromosome segregation in meiosis protein 4", "protein_names_refseq": "Csm4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL200W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11470404;12514182;17322287;18585352;24374639;9169875", "class_list": "", "function": "Involved in chromosome segregation during meiosis. Involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, 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"0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08975-1", "uniprot_id": [ { "id": "THI21_YEAST", "url": "https://www.uniprot.org/uniprot/Q08975", "type": "external" } ], "mass": 61334.0, "length": 551, "protein_name": "Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21", "gene_name": "THI21", "organism": "Yeast", "refseq_name": "bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase", "refseq_ac": [ { "id": "NP_015065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015065", "type": "external" } ], "gene_names_uniprotkb": "THI21", "gene_names_refseq": "THI21", "protein_names_uniprotkb": "Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21; 2.7.1.49; 2.7.4.7; HMP kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase; Hydroxymethylpyrimidine kinase; Hydroxymethylpyrimidine phosphate kinase", "protein_names_refseq": "bifunctional hydroxymethylpyrimidine 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activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009229 thiamine diphosphate biosynthetic process;GO:0009228 thiamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q08975-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08981-1", "uniprot_id": [ { "id": "ACM1_YEAST", "url": "https://www.uniprot.org/uniprot/Q08981", "type": "external" } ], "mass": 23870.0, "length": 209, "protein_name": "APC/C-CDH1 modulator 1", "gene_name": "ACM1", "organism": "Yeast", "refseq_name": "Acm1p", "refseq_ac": [ { "id": "NP_015056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015056", "type": "external" } ], "gene_names_uniprotkb": "ACM1", "gene_names_refseq": "ACM1", "protein_names_uniprotkb": "APC/C-CDH1 modulator 1", "protein_names_refseq": "Acm1p", "tax_id": 559292, "disease": "", "pathway": " 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division;GO:0031397 negative regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q08981-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08989-1", "uniprot_id": [ { "id": "YP277_YEAST", "url": "https://www.uniprot.org/uniprot/Q08989", "type": "external" } ], "mass": 54538.0, "length": 487, "protein_name": "Uncharacterized protein YPL277C", "gene_name": "", "organism": "Yeast", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_015046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015046", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein YPL277C", "protein_names_refseq": "uncharacterized protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL277C)", "pathway_count": 1, "publication_count": 3, 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"https://www.uniprot.org/uniprot/Q12021", "type": "external" } ], "mass": 58230.0, "length": 506, "protein_name": "Radiation-sensitive protein 28", "gene_name": "RAD28", "organism": "Yeast", "refseq_name": "Rad28p", "refseq_ac": [ { "id": "NP_010313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010313", "type": "external" } ], "gene_names_uniprotkb": "RAD28; YD9813.08c", "gene_names_refseq": "RAD28", "protein_names_uniprotkb": "Radiation-sensitive protein 28", "protein_names_refseq": "Rad28p", "tax_id": 559292, "disease": "UV-sensitive syndrome (Disease Ontology:DOID:0060240); Cockayne syndrome A (Disease Ontology:DOID:0080907); Cockayne syndrome (Disease Ontology:DOID:2962)", "pathway": " (sce:YDR030C); (R-SCE-6782135); (R-SCE-6782210)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "22814378;24374639;8830695;9169867;9336455", "class_list": "", "function": "Involved in transcription-coupled repair nucleotide excision repair (NER) of UV-induced DNA lesions., 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"gene_name": "SRO7", "organism": "Yeast", "refseq_name": "Rab GTPase-binding protein SRO7", "refseq_ac": [ { "id": "NP_015357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015357", "type": "external" } ], "gene_names_uniprotkb": "SRO7; SNI1; SOP1; YP9367.12", "gene_names_refseq": "SNI1; SOP1; SRO7", "protein_names_uniprotkb": "Exocytosis protein SRO7; Lethal(2) giant larvae protein homolog SRO7; Polarity protein SRO7; Sodium protection protein 1; Suppressor of RHO3 protein 7", "protein_names_refseq": "Rab GTPase-binding protein SRO7", "tax_id": 559292, "disease": "brain cancer (Disease Ontology:DOID:1319); cancer (Disease Ontology:DOID:162); kidney cancer (Disease Ontology:DOID:263); carcinoma (Disease Ontology:DOID:305); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (sce:YPR032W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10402465;14676322;15964280;16390997;17005914;17392788;17563356;18407956;19779198;21248204;23749301;24374639;24440502;32597660;33481703;33491328;9169875;9691031;9837945", "class_list": "", "function": "Acts as an allosteric regulator of polarized exocytosis by promoting the targeted fusion of vesicles with the plasma membrane. Coordinates the spatial and temporal nature of both Rab-dependent tethering and SNARE-dependent membrane fusion of exocytic vesicles with the plasma membrane. Required for targeting of the sodium pumping ATPase ENA1 to the Cell Surface, thus being involved in maintenance of ion homeostasis in cells exposed to NaCl stress. May be involved in the targeting of the myosin proteins to their intrinsic pathways. Multicopy suppressor of RHO3. May also participate in the maintenance of cell polarity and bud growth., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W442", "ec_number_list": [], "go_molecular_function": "GO:0045159 myosin II binding;GO:0005096 GTPase activator activity;GO:0019905 syntaxin binding;GO:0031267 small GTPase binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043332 mating projection tip", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0006887 exocytosis;GO:0030010 establishment of cell polarity;GO:0006893 Golgi to plasma membrane transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q12038-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12043-1", "uniprot_id": [ { "id": "TGL5_YEAST", "url": "https://www.uniprot.org/uniprot/Q12043", "type": "external" } ], "mass": 84716.0, "length": 749, "protein_name": "Triacylglycerol lipase 5", "gene_name": "TGL5", "organism": "Yeast", "refseq_name": "triacylglycerol lipase", "refseq_ac": [ { "id": "NP_014724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014724", "type": "external" } ], "gene_names_uniprotkb": "TGL5; STC2; YOR29-32; YOR2964C", "gene_names_refseq": "STC2; TGL5", "protein_names_uniprotkb": "Triacylglycerol lipase 5; 3.1.1.3; Lipase 5; TAG lipase 5; TG lipase 5", "protein_names_refseq": "triacylglycerol lipase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR081C)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "14562095;14562106;16135509;17287358;18407956;19684113;19779198;19795423;19823750;20016004;21126336;21820081;22218487;23749301;24374639;24868093;27170177;32597660;33481703;33491328;9133743;9169874;9200815", "class_list": "", "function": "Lipid particle-localized triacylglycerol (TAG) lipase. The lipid droplet/particle is a lipid storage compartment which serves as a depot of energy and building blocks for membrane lipid biosynthesis. Involved in the mobilization of the non-polar storage lipids triacylglycerols (TAGs) from lipid particles by hydrolysis of TAGs, releasing and supplying specific fatty acids to the appropriate metabolic pathways (PubMed:16135509). Also catalyzes the acylation of lysophosphatidic acid (LPA) (PubMed:20016004)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "D6W2E4;Q7LH13", "ec_number_list": [ { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.1.1.101", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.101", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" } ], "go_molecular_function": "GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005811 lipid droplet", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0006642 triglyceride mobilization;GO:0030435 sporulation resulting in formation of a cellular spore", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q12043-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12083-1", "uniprot_id": [ { "id": "MLH3_YEAST", "url": "https://www.uniprot.org/uniprot/Q12083", "type": "external" } ], "mass": 82001.0, "length": 715, "protein_name": "DNA mismatch repair protein MLH3", "gene_name": "MLH3", "organism": "Yeast", "refseq_name": "mismatch repair protein MLH3", "refseq_ac": [ { "id": "NP_015161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015161", "type": "external" } ], "gene_names_uniprotkb": "MLH3; P2550", "gene_names_refseq": "MLH3", "protein_names_uniprotkb": "DNA mismatch repair protein MLH3; MutL protein homolog 3", "protein_names_refseq": "mismatch repair protein MLH3", "tax_id": 559292, "disease": "hereditary nonpolyposis colorectal cancer type 7 (Disease Ontology:DOID:0070276); endometrial cancer (Disease Ontology:DOID:1380); Lynch syndrome (Disease Ontology:DOID:3883); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YPL164C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10570173;10679328;12200140;24374639;33481703;8948103;9169875;9770499", "class_list": "", "function": "Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLbeta heterodimer, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in promoting meiotic crossing-over and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3K4", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0030983 mismatched DNA binding;GO:0140664 ATP-dependent DNA damage sensor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0032300 mismatch repair complex;GO:0097587 MutLgamma complex", "go_biological_process": "GO:0000710 meiotic mismatch repair;GO:0006298 mismatch repair;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q12083-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12143-1", "uniprot_id": [ { "id": "NSL1_YEAST", "url": "https://www.uniprot.org/uniprot/Q12143", "type": "external" } ], "mass": 25416.0, "length": 216, "protein_name": "Kinetochore-associated protein NSL1", "gene_name": "NSL1", "organism": "Yeast", "refseq_name": "MIND complex subunit NSL1", "refseq_ac": [ { "id": "NP_015091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015091", "type": "external" } ], "gene_names_uniprotkb": "NSL1", "gene_names_refseq": "NSL1", "protein_names_uniprotkb": "Kinetochore-associated protein NSL1", "protein_names_refseq": "MIND complex subunit NSL1", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL233W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12455957;14562106;14602074;14633972;14657030;14690591;17322287;20489023;22814378;24374639;33491328;9169875", "class_list": "", "function": "Acts as an essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity. MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules. NSL1 facilitates the attachment of two of the DASH complex components, DAD2 and SPC19, to the kinetochore in a microtubule-dependent manner., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3D7;Q6B152", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0000776 kinetochore;GO:0000940 outer kinetochore;GO:0000444 MIS12/MIND type complex", "go_biological_process": "GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0000070 mitotic sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q12143-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12146-1", "uniprot_id": [ { "id": "PSF3_YEAST", "url": "https://www.uniprot.org/uniprot/Q12146", "type": "external" } ], "mass": 21952.0, "length": 194, "protein_name": "DNA replication complex GINS protein PSF3", "gene_name": "PSF3", "organism": "Yeast", "refseq_name": "DNA replication protein PSF3", "refseq_ac": [ { "id": "NP_014495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014495", "type": "external" } ], "gene_names_uniprotkb": "PSF3", "gene_names_refseq": "PSF3", "protein_names_uniprotkb": "DNA replication complex GINS protein PSF3; Partner of Sld five 3", "protein_names_refseq": "DNA replication protein PSF3", "tax_id": 559292, "disease": "Meier-Gorlin syndrome (Disease Ontology:DOID:0060306)", "pathway": " (sce:YOL146W); (R-SCE-176974)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12730134;12748633;14562106;14690591;17322287;24374639;8553699;9169874", "class_list": "", "function": "Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1S3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031261 DNA replication preinitiation complex;GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0000811 GINS complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006260 DNA replication;GO:0006270 DNA replication initiation;GO:0000727 double-strand break repair via break-induced replication;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q12146-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12149-1", "uniprot_id": [ { "id": "RRP6_YEAST", "url": "https://www.uniprot.org/uniprot/Q12149", "type": "external" } ], "mass": 84039.0, "length": 733, "protein_name": "Exosome complex exonuclease RRP6", "gene_name": "RRP6", "organism": "Yeast", "refseq_name": "exosome nuclease subunit RRP6", "refseq_ac": [ { "id": "NP_014643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014643", "type": "external" } ], "gene_names_uniprotkb": "RRP6; UNC733", "gene_names_refseq": "RRP6", "protein_names_uniprotkb": "Exosome complex exonuclease RRP6; 3.1.13.-; Ribosomal RNA-processing protein 6; Rrp6p", "protein_names_refseq": "exosome nuclease subunit RRP6", "tax_id": 559292, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (sce:YOR001W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 30, "publication_id_list": "10465791;10611239;12923258;12972615;14562095;14562106;15489286;16829593;16882719;17173052;17174896;17322287;17330950;17563356;18407956;18631361;19779198;21126336;21705430;22814378;23749301;24374639;30181345;30516470;32597660;33481703;33491328;8896276;9169874;9582370", "class_list": "", "function": "Nuclear-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP6 has 3'-5' exonuclease activity which is not modulated upon association with Exo-9 suggesting that the complex inner RNA-binding path is not used to access its active site., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W267;Q6B280", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.1.1.260", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.260", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" } ], "go_molecular_function": "GO:0000166 nucleotide binding;GO:0003727 single-stranded RNA binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0042134 rRNA primary transcript binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000176 nuclear exosome (RNase complex)", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0034473 U1 snRNA 3'-end processing;GO:0034476 U5 snRNA 3'-end processing;GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process;GO:0032204 regulation of telomere maintenance", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q12149-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12159-1", "uniprot_id": [ { "id": "YRA1_YEAST", "url": "https://www.uniprot.org/uniprot/Q12159", "type": "external" } ], "mass": 24956.0, "length": 226, "protein_name": "RNA annealing protein YRA1", "gene_name": "YRA1", "organism": "Yeast", "refseq_name": "RNA-binding protein YRA1", "refseq_ac": [ { "id": "NP_010669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010669", "type": "external" } ], "gene_names_uniprotkb": "YRA1; D9481.2; D9509.1", "gene_names_refseq": "SHE11; YRA1", "protein_names_uniprotkb": "RNA annealing protein YRA1", "protein_names_refseq": "RNA-binding protein YRA1", "tax_id": 559292, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (sce:YDR381W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11979277;14517302;15584090;15665377;18407956;19779198;19795423;19823750;21126336;22218487;22814378;23749301;24374639;24909858;33481703;33491328;9149233;9169867", "class_list": "", "function": "RNA-binding RNA annealing protein. May have a role in pre-mRNA metabolism. Component the TREX complex, which operates in coupling transcription elongation to mRNA export., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT14", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0071667 DNA/RNA hybrid binding;GO:1990119 RNA helicase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000346 transcription export complex", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0006368 transcription elongation by RNA polymerase II;GO:0006283 transcription-coupled nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q12159-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12230-1", "uniprot_id": [ { "id": "LSP1_YEAST", "url": "https://www.uniprot.org/uniprot/Q12230", "type": "external" } ], "mass": 38071.0, "length": 341, "protein_name": "Sphingolipid long chain base-responsive protein LSP1", "gene_name": "LSP1", "organism": "Yeast", "refseq_name": "lipid-binding protein LSP1", "refseq_ac": [ { "id": "NP_015321", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015321", "type": "external" } ], "gene_names_uniprotkb": "LSP1", "gene_names_refseq": "LSP1", "protein_names_uniprotkb": "Sphingolipid long chain base-responsive protein LSP1", "protein_names_refseq": "lipid-binding protein LSP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL004C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "14562095;14562106;15016821;15665377;16496001;17330950;17563356;18407956;19269952;19756047;19779198;19795423;19823750;20702584;21126336;21177495;23749301;24374639;32597660;33481703;33491328;9169875", "class_list": "", "function": "Together with PIL1, main component of eisosomes, structures at the cell periphery underneath the plasma membrane that mark the site of endocytosis. Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W408", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0006897 endocytosis;GO:0061024 membrane organization;GO:0009408 response to heat;GO:0070941 eisosome assembly", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q12230-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12248-1", "uniprot_id": [ { "id": "DAD1_YEAST", "url": "https://www.uniprot.org/uniprot/Q12248", "type": "external" } ], "mass": 10516.0, "length": 94, "protein_name": "DASH complex subunit DAD1", "gene_name": "DAD1", "organism": "Yeast", "refseq_name": "Dad1p", "refseq_ac": [ { "id": "NP_010299", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010299", "type": "external" } ], "gene_names_uniprotkb": "DAD1", "gene_names_refseq": "DAD1", "protein_names_uniprotkb": "DASH complex subunit DAD1; DUO1 and DAM1-interacting protein 1; Outer kinetochore protein DAD1", "protein_names_refseq": "Dad1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR016C)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "11782438;11799062;12408861;14562095;14562106;15640796;15664196;16415853;16715078;16777964;17322287;17460120;17643123;18079178;18407956;19779198;19795423;19823750;20190278;23749301;24374639;24930965;25236177;33481703;33491328;36651597;36701236;9169867", "class_list": "", "function": "Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerization to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase (PubMed:15664196, PubMed:16415853, PubMed:16777964, PubMed:17460120, PubMed:17643123). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules (PubMed:11782438). Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle (PubMed:11782438). During spindle-kinetochore attachment, kinetochores first attach to the lateral surface of spindle microtubules, which supports the congression of chromosomes toward the middle of the dividing cell; they then slide along towards the spindle pole, a process independent of the DASH complex but requiring the NDC80 complex (PubMed:25236177). When the end of a disassembling microtubule reaches the laterally attached kinetochore, the DASH complex together with the NDC80 complex and STU2 convert lateral attachment to end-on capture to produce a structure that can track with microtubule shortening and sustain attachment when tension is applied across sister kinetochores upon their biorientation (PubMed:15640796, PubMed:15664196, PubMed:25236177). Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached DASH complex to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids (PubMed:16415853, PubMed:16777964). Incorrect microtubule attachments are corrected by releasing microubules from the kinetochore through phosphorylation by IPL1 of kinetochore components (PubMed:12408861). Links the microtubule cytoskeleton to chromosomes during interphase (PubMed:36701236). Also contributes to the poleward transport of kinetochores on microtubules following centromeric DNA replication in S-phase (PubMed:18079178)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS02", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005876 spindle microtubule;GO:0072686 mitotic spindle;GO:0042729 DASH complex;GO:0044732 mitotic spindle pole body", "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0031116 positive regulation of microtubule polymerization;GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore;GO:1990758 mitotic sister chromatid biorientation", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q12248-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12250-1", "uniprot_id": [ { "id": "RPN5_YEAST", "url": "https://www.uniprot.org/uniprot/Q12250", "type": "external" } ], "mass": 51768.0, "length": 445, "protein_name": "26S proteasome regulatory subunit RPN5", "gene_name": "RPN5", "organism": "Yeast", "refseq_name": "proteasome regulatory particle lid subunit RPN5", "refseq_ac": [ { "id": "NP_010134", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010134", "type": "external" } ], "gene_names_uniprotkb": "RPN5; D1572; NAS5", "gene_names_refseq": "NAS5; RPN5", "protein_names_uniprotkb": "26S proteasome regulatory subunit RPN5; Proteasome non-ATPase subunit 5", "protein_names_refseq": "proteasome regulatory particle lid subunit RPN5", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YDL147W); (R-SCE-1236978); (R-SCE-5668541); (R-SCE-5689880); (R-SCE-6798695); (R-SCE-9907900)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "12504901;14562106;19795423;19823750;20486117;22927375;24374639;33491328;8972581;9169867;9426256", "class_list": "", "function": "Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRK1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0005737 cytoplasm;GO:0000502 proteasome complex;GO:0008541 proteasome regulatory particle, lid subcomplex;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000338 protein deneddylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q12250-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12271-1", "uniprot_id": [ { "id": "INP53_YEAST", "url": "https://www.uniprot.org/uniprot/Q12271", "type": "external" } ], "mass": 124577.0, "length": 1107, "protein_name": "Polyphosphatidylinositol phosphatase INP53", "gene_name": "INP53", "organism": "Yeast", "refseq_name": "phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53", "refseq_ac": [ { "id": "NP_014752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014752", "type": "external" } ], "gene_names_uniprotkb": "INP53; SJL3; SOP2; YOR3231w", "gene_names_refseq": "INP53; SJL3; SOP2", "protein_names_uniprotkb": "Polyphosphatidylinositol phosphatase INP53; Suppressor of PMA1 protein 2; Synaptojanin-like protein 3", "protein_names_refseq": "phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53", "tax_id": 559292, "disease": "early-onset Parkinson's disease (Disease Ontology:DOID:0060894); Parkinson's disease 20 (Disease Ontology:DOID:0060898); developmental and epileptic encephalopathy 53 (Disease Ontology:DOID:0080464); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (sce:YOR109W); (R-SCE-1660499); (R-SCE-1855183); (R-SCE-1855204)", "pathway_count": 4, "publication_count": 35, "publication_id_list": "10029994;10224048;10625610;10628971;11094088;11598201;12606027;12686590;14562095;14562106;15169871;15691741;17330950;17563356;18407956;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22814378;23749301;24374639;32597660;33229814;33481703;33491328;34965436;9169874;9200815;9265642;9560389;9788876", "class_list": "", "function": "Dephosphorylates a number of phosphatidylinositols (PIs) like phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), but also phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in clathrin-mediated protein sorting at the TGN., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 12, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 12, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 12, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 35, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "D6W2G8", "ec_number_list": [ { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity;GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0030479 actin cortical patch", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "Q12271-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12277-1", "uniprot_id": [ { "id": "RRP42_YEAST", "url": "https://www.uniprot.org/uniprot/Q12277", "type": "external" } ], "mass": 29055.0, "length": 265, "protein_name": "Exosome complex component RRP42", "gene_name": "RRP42", "organism": "Yeast", "refseq_name": "exosome non-catalytic core subunit RRP42", "refseq_ac": [ { "id": "NP_010172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010172", "type": "external" } ], "gene_names_uniprotkb": "RRP42", "gene_names_refseq": "RRP42", "protein_names_uniprotkb": "Exosome complex component RRP42; Ribosomal RNA-processing protein 42", "protein_names_refseq": "exosome non-catalytic core subunit RRP42", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL111C); (R-SCE-429958); (R-SCE-450385); (R-SCE-450513); (R-SCE-6791226)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10465791;14562095;14562106;17173052;17174896;24374639;8923743;9169867;9390555", "class_list": "", "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP42 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VRN9", "ec_number_list": [], "go_molecular_function": "GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000176 nuclear exosome (RNase complex);GO:0000177 cytoplasmic exosome (RNase complex)", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0034473 U1 snRNA 3'-end processing;GO:0034476 U5 snRNA 3'-end processing;GO:0006396 RNA processing;GO:0016075 rRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q12277-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12280-1", "uniprot_id": [ { "id": "IQG1_YEAST", "url": "https://www.uniprot.org/uniprot/Q12280", "type": "external" } ], "mass": 172830.0, "length": 1495, "protein_name": "Ras GTPase-activating-like protein IQG1", "gene_name": "IQG1", "organism": "Yeast", "refseq_name": "Iqg1p", "refseq_ac": [ { "id": "NP_015082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015082", "type": "external" } ], "gene_names_uniprotkb": "IQG1; CYK1", "gene_names_refseq": "CYK1; IQG1", "protein_names_uniprotkb": "Ras GTPase-activating-like protein IQG1; Cytokinesis protein 1; IQGAP-related protein 1", "protein_names_refseq": "Iqg1p", "tax_id": 559292, "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YPL242C); (R-SCE-5626467); (R-SCE-6798695); (R-SCE-8980692); (R-SCE-9013106); (R-SCE-9013406); (R-SCE-9013420); (R-SCE-9013424)", "pathway_count": 8, "publication_count": 18, "publication_id_list": "11082046;12446742;14562095;14562106;17563356;18344988;18407956;19779198;23749301;24374639;32597660;33481703;33491328;9169875;9382845;9442111;9679143;9950677", "class_list": "", "function": "Required for the assembly and the contraction of the actomyosin ring at the bud neck during cytokinesis. Seems to be involved in additional tasks during cell division like axial bud-site selection and targeted secretion by recruiting the spatial landmark BUD4, the septin CDC12 and the secretion landmark SEC3 to the bud neck. May be regulated by calcium ions., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 33, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W3C9", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005516 calmodulin binding;GO:0051015 actin filament binding;GO:0032038 myosin II heavy chain binding;GO:0032027 myosin light chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0000142 cellular bud neck contractile ring;GO:0005935 cellular bud neck", "go_biological_process": "GO:0000281 mitotic cytokinesis;GO:0032465 regulation of cytokinesis;GO:1903479 mitotic actomyosin contractile ring assembly actin filament organization;GO:1903475 mitotic actomyosin contractile ring assembly;GO:0031991 regulation of actomyosin contractile ring contraction", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q12280-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12318-1", "uniprot_id": [ { "id": "PSY3_YEAST", "url": "https://www.uniprot.org/uniprot/Q12318", "type": "external" } ], "mass": 28251.0, "length": 242, "protein_name": "Platinum sensitivity protein 3", "gene_name": "PSY3", "organism": "Yeast", "refseq_name": "Psy3p", "refseq_ac": [ { "id": "NP_013480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013480", "type": "external" } ], "gene_names_uniprotkb": "PSY3; L8039.17", "gene_names_refseq": "PSY3", "protein_names_uniprotkb": "Platinum sensitivity protein 3", "protein_names_refseq": "Psy3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR376C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12149442;12482937;12972632;14562106;15173006;15654096;17322287;19496932;20489023;22814378;24374639;33481703;33491328;9169871", "class_list": "", "function": "Required for resistance to the DNA-damaging agents methyl methanesulfonate (MMS), cisplatin and oxaliplatin, but not to mitomycin C. Plays a role in protection against mutation accumulation. May be a component of the recombination-repair pathway., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ12", "ec_number_list": [], "go_molecular_function": "GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0035861 site of double-strand break;GO:0097196 Shu complex", "go_biological_process": "GO:0000725 recombinational repair;GO:0000730 DNA recombinase assembly;GO:0070987 error-free translesion synthesis;GO:0042275 error-free postreplication DNA repair;GO:1903112 positive regulation of single-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q12318-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12330-1", "uniprot_id": [ { "id": "RUXE_YEAST", "url": "https://www.uniprot.org/uniprot/Q12330", "type": "external" } ], "mass": 10375.0, "length": 94, "protein_name": "Small nuclear ribonucleoprotein E", "gene_name": "SME1", "organism": "Yeast", "refseq_name": "mRNA splicing protein SME1", "refseq_ac": [ { "id": "NP_014802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014802", "type": "external" } ], "gene_names_uniprotkb": "SME1", "gene_names_refseq": "SME1", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein E; Sm protein E; Sm-E; SmE; snRNP-E", "protein_names_refseq": "mRNA splicing protein SME1", "tax_id": 559292, "disease": "lupus nephritis (Disease Ontology:DOID:0080162); hypotrichosis 1 (Disease Ontology:DOID:0110698); hypotrichosis 11 (Disease Ontology:DOID:0110708); prostate cancer (Disease Ontology:DOID:10283); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); neuroblastoma (Disease Ontology:DOID:769); nasopharynx carcinoma (Disease Ontology:DOID:9261); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (sce:YOR159C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10369684;10449419;11027265;11302706;11804584;14562106;17322287;24374639;33481703;8918241;9012791;9046089;9169874;9528767", "class_list": "", "function": "Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2L6", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:1990935 splicing factor binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005686 U2 snRNP;GO:0034715 pICln-Sm protein complex", "go_biological_process": "GO:0036261 7-methylguanosine cap hypermethylation;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q12330-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12341-1", "uniprot_id": [ { "id": "HAT1_YEAST", "url": "https://www.uniprot.org/uniprot/Q12341", "type": "external" } ], "mass": 43873.0, "length": 374, "protein_name": "Histone acetyltransferase type B catalytic subunit", "gene_name": "HAT1", "organism": "Yeast", "refseq_name": "histone acetyltransferase catalytic subunit HAT1", "refseq_ac": [ { "id": "NP_015324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015324", "type": "external" } ], "gene_names_uniprotkb": "HAT1; LPA16W; YP8132.12", "gene_names_refseq": "HAT1; KAT1", "protein_names_uniprotkb": "Histone acetyltransferase type B catalytic subunit; 2.3.1.48", "protein_names_refseq": "histone acetyltransferase catalytic subunit HAT1", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL001W); (R-SCE-3214847)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10982821;12417736;14761951;15099519;17322287;18407956;23749301;24374639;24835250;33491328;7559580;8858151;9169875;9575221;9727486", "class_list": "", "function": "Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of free histone H4 in the cytoplasm. The complex is also found in the nucleus, however it is not certain that it modifies histone H4 when packaged in chromatin. Histone H4 'Lys-12' acetylation is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W411;Q6Q5I5", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding;GO:0004402 histone acetyltransferase activity;GO:0010485 histone H4 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000123 histone acetyltransferase complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q12341-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12342-1", "uniprot_id": [ { "id": "LDB17_YEAST", "url": "https://www.uniprot.org/uniprot/Q12342", "type": "external" } ], "mass": 56549.0, "length": 491, "protein_name": "Protein LDB17", "gene_name": "LDB17", "organism": "Yeast", "refseq_name": "Ldb17p", "refseq_ac": [ { "id": "NP_010135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010135", "type": "external" } ], "gene_names_uniprotkb": "LDB17; D1575", "gene_names_refseq": "LDB17", "protein_names_uniprotkb": "Protein LDB17; Low dye-binding protein 17", "protein_names_refseq": "Ldb17p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL146W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562095;14562106;15993632;17322287;17330950;18407956;19684113;19779198;20702584;21126336;21177495;23749301;24374639;33481703;33491328;8972581;9169867", "class_list": "", "function": "May be involved in protein-linked oligosaccharide phosphorylation since the deletion reduces the negative charge of the cell surface., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRK2", "ec_number_list": [], "go_molecular_function": "GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030479 actin cortical patch;GO:0005933 cellular bud;GO:0005935 cellular bud neck", "go_biological_process": "GO:0006897 endocytosis;GO:0051666 actin cortical patch localization;GO:0000147 actin cortical patch assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q12342-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12343-1", "uniprot_id": [ { "id": "MED4_YEAST", "url": "https://www.uniprot.org/uniprot/Q12343", "type": "external" } ], "mass": 32205.0, "length": 284, "protein_name": "Mediator of RNA polymerase II transcription subunit 4", "gene_name": "MED4", "organism": "Yeast", "refseq_name": "Med4p", "refseq_ac": [ { "id": "NP_014817", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014817", "type": "external" } ], "gene_names_uniprotkb": "MED4; O3630", "gene_names_refseq": "MED4", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 4; Mediator complex subunit 4", "protein_names_refseq": "Med4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR174W)", "pathway_count": 1, "publication_count": 32, "publication_id_list": "11555651;12191485;14562095;14562106;14749387;14988503;15126497;15175151;15477388;15710619;16002404;16076843;16263706;17192271;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;22814378;23749301;24374639;32597660;33481703;33491328;8972579;9169874;9420330", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2N0", "ec_number_list": [], "go_molecular_function": "GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat;GO:0006366 transcription by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q12343-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12347-1", "uniprot_id": [ { "id": "HRT3_YEAST", "url": "https://www.uniprot.org/uniprot/Q12347", "type": "external" } ], "mass": 40475.0, "length": 344, "protein_name": "F-box protein HRT3", "gene_name": "HRT3", "organism": "Yeast", "refseq_name": "SCF ubiquitin ligase complex subunit HRT3", "refseq_ac": [ { "id": "NP_013198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013198", "type": "external" } ], "gene_names_uniprotkb": "HRT3", "gene_names_refseq": "HRT3", "protein_names_uniprotkb": "F-box protein HRT3; High level expression reduces Ty3 transposition protein 3", "protein_names_refseq": "SCF ubiquitin ligase complex subunit HRT3", "tax_id": 559292, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (sce:YLR097C); (R-SCE-983168)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11283612;14747994;22814378;24374639;33491328;9169871", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY97", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0071406 cellular response to methylmercury", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q12347-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12363-1", "uniprot_id": [ { "id": "WTM1_YEAST", "url": "https://www.uniprot.org/uniprot/Q12363", "type": "external" } ], "mass": 48383.0, "length": 437, "protein_name": "Transcriptional modulator WTM1", "gene_name": "WTM1", "organism": "Yeast", "refseq_name": "transcriptional modulator", "refseq_ac": [ { "id": "NP_014873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014873", "type": "external" } ], "gene_names_uniprotkb": "WTM1; YOR50-20", "gene_names_refseq": "WTM1", "protein_names_uniprotkb": "Transcriptional modulator WTM1", "protein_names_refseq": "transcriptional modulator", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR230W); (R-SCE-3214815)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "14562106;16432237;17322287;17330950;17563356;18407956;19779198;19795423;19823750;21177495;23749301;24374639;32597660;33481703;33491328;8840505;9169874", "class_list": "", "function": "Transcriptional modulator with roles in meiotic regulation and silencing. Acts either as an adapter to facilitate nuclear import by KAP122 of the RNR2-RNR4 heterodimer, also called beta-beta' subunit, which corresponds to the small subunit of the ribonucleotide reductase (RNR); or as an anchor to retain RNR2-RNR4 in the nucleus., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2T4;O00041", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0070210 Rpd3L-Expanded complex;GO:0033698 Rpd3L complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q12363-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12366-1", "uniprot_id": [ { "id": "NDJ1_YEAST", "url": "https://www.uniprot.org/uniprot/Q12366", "type": "external" } ], "mass": 40856.0, "length": 352, "protein_name": "Non-disjunction protein 1", "gene_name": "NDJ1", "organism": "Yeast", "refseq_name": "Ndj1p", "refseq_ac": [ { "id": "NP_014537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014537", "type": "external" } ], "gene_names_uniprotkb": "NDJ1; TAM1", "gene_names_refseq": "NDJ1; TAM1", "protein_names_uniprotkb": "Non-disjunction protein 1; Telomere-associated meiosis protein 1", "protein_names_refseq": "Ndj1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL104C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10944222;11018056;15579679;15694306;16254243;16648465;17322287;17495028;18407956;18585352;24374639;7502582;9157883;9169874;9242487;9716409", "class_list": "", "function": "Required for telomeric clustering (bouquet stage) during meiosis 1 prophase, formation and efficient homolog pairing, meiosis 1 disjunction, and telomere deletion during meiosis. Also promotes meiotic recombination., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1W2", "ec_number_list": [], "go_molecular_function": "GO:0042162 telomeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000781 chromosome, telomeric region;GO:0035974 meiotic spindle pole body", "go_biological_process": "GO:0070197 meiotic attachment of telomere to nuclear envelope;GO:0007129 homologous chromosome pairing at meiosis;GO:0007131 reciprocal meiotic recombination;GO:0045141 meiotic telomere clustering;GO:2000711 positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q12366-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12380-1", "uniprot_id": [ { "id": "ATG5_YEAST", "url": "https://www.uniprot.org/uniprot/Q12380", "type": "external" } ], "mass": 33560.0, "length": 294, "protein_name": "Autophagy protein 5", "gene_name": "ATG5", "organism": "Yeast", "refseq_name": "Atg5p", "refseq_ac": [ { "id": "NP_015176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015176", "type": "external" } ], "gene_names_uniprotkb": "ATG5; APG5; P2601", "gene_names_refseq": "APG5; ATG5", "protein_names_uniprotkb": "Autophagy protein 5", "protein_names_refseq": "Atg5p", "tax_id": 559292, "disease": "hereditary ataxia (Disease Ontology:DOID:0050951); autosomal recessive spinocerebellar ataxia 25 (Disease Ontology:DOID:0080259); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); ischemia (Disease Ontology:DOID:326)", "pathway": " (sce:YPL149W); (R-SCE-1632852); (R-SCE-8934903)", "pathway_count": 3, "publication_count": 35, "publication_id_list": "10406794;10712513;11149920;11689437;11897782;12965207;14536056;14562106;15155809;15247238;15947785;16874032;17012802;17192262;17295840;17890363;17986448;18421155;18497569;18625846;18701704;18725539;21703229;22768199;23064152;23238393;23503366;23549786;24374639;35363116;8224160;8921905;8948103;9169875;9759731", "class_list": "", "function": "Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes. ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity. Plays a role in the regulation of filamentous growth and chronological longevity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3M0", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0016787 hydrolase activity;GO:0140355 cargo receptor ligand activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane;GO:0005776 autophagosome;GO:0034045 phagophore assembly site membrane", "go_biological_process": "GO:0051365 cellular response to potassium ion starvation;GO:0000045 autophagosome assembly;GO:0016236 macroautophagy;GO:0000423 mitophagy;GO:0044804 nucleophagy", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q12380-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12396-1", "uniprot_id": [ { "id": "EMP46_YEAST", "url": "https://www.uniprot.org/uniprot/Q12396", "type": "external" } ], "mass": 50947.0, "length": 444, "protein_name": "Protein EMP46", "gene_name": "EMP46", "organism": "Yeast", "refseq_name": "Emp46p", "refseq_ac": [ { "id": "NP_013181", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013181", "type": "external" } ], "gene_names_uniprotkb": "EMP46", "gene_names_refseq": "EMP46", "protein_names_uniprotkb": "Protein EMP46; 46 kDa endomembrane protein", "protein_names_refseq": "Emp46p", "tax_id": 559292, "disease": "autosomal dominant intellectual developmental disorder 69 (Disease Ontology:DOID:0061042); autosomal recessive intellectual developmental disorder 52 (Disease Ontology:DOID:0081215); factor XIII deficiency (Disease Ontology:DOID:2211); factor V deficiency (Disease Ontology:DOID:2216)", "pathway": " (sce:YLR080W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12134087;12206772;12857885;14562095;14627716;16439369;16847258;24374639;9169871", "class_list": "", "function": "Involved in the secretion of glycoproteins and in nucleus architecture and gene silencing., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY80", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0005537 D-mannose binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q12396-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12425-1", "uniprot_id": [ { "id": "ISA2_YEAST", "url": "https://www.uniprot.org/uniprot/Q12425", "type": "external" } ], "mass": 20877.0, "length": 185, "protein_name": "Iron-sulfur assembly protein 2", "gene_name": "ISA2", "organism": "Yeast", "refseq_name": "Isa2p", "refseq_ac": [ { "id": "NP_015392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015392", "type": "external" } ], "gene_names_uniprotkb": "ISA2; YP9499.22", "gene_names_refseq": "ISA2", "protein_names_uniprotkb": "Iron-sulfur assembly protein 2", "protein_names_refseq": "Isa2p", "tax_id": 559292, "disease": "multiple mitochondrial dysfunctions syndrome 4 (Disease Ontology:DOID:0080136)", "pathway": " (sce:YPR067W); (R-SCE-1362409)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10913600;14562106;24374639;9169875", "class_list": "", "function": "Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W471", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0051604 protein maturation;GO:0044572 [4Fe-4S] cluster assembly;GO:0009102 biotin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q12425-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12440-1", "uniprot_id": [ { "id": "APC2_YEAST", "url": "https://www.uniprot.org/uniprot/Q12440", "type": "external" } ], "mass": 99978.0, "length": 853, "protein_name": "Anaphase-promoting complex subunit 2", "gene_name": "APC2", "organism": "Yeast", "refseq_name": "anaphase promoting complex subunit 2", "refseq_ac": [ { "id": "NP_013228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013228", "type": "external" } ], "gene_names_uniprotkb": "APC2; L3105; L3108; RSI1", "gene_names_refseq": "APC2; RSI1; TID2", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 2", "protein_names_refseq": "anaphase promoting complex subunit 2", "tax_id": 559292, "disease": "aplastic anemia (Disease Ontology:DOID:12449); primary angle-closure glaucoma (Disease Ontology:DOID:1405); lung adenocarcinoma (Disease Ontology:DOID:3910); lung adenoma (Disease Ontology:DOID:5386); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (sce:YLR127C); (R-SCE-983168)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11961546;14562095;14562106;15905473;18407956;23749301;24374639;33491328;9090053;9169871;9469814", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYC2;Q2VQX4;Q7LGV7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0007346 regulation of mitotic cell cycle;GO:0016567 protein ubiquitination;GO:0010458 exit from mitosis;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q12440-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12452-1", "uniprot_id": [ { "id": "ERG27_YEAST", "url": "https://www.uniprot.org/uniprot/Q12452", "type": "external" } ], "mass": 39725.0, "length": 347, "protein_name": "3-keto-steroid reductase ERG27", "gene_name": "ERG27", "organism": "Yeast", "refseq_name": "3-keto-steroid reductase", "refseq_ac": [ { "id": "NP_013201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013201", "type": "external" } ], "gene_names_uniprotkb": "ERG27", "gene_names_refseq": "ERG27", "protein_names_uniprotkb": "3-keto-steroid reductase ERG27; 1.1.1.270; Ergosterol biosynthetic protein 27", "protein_names_refseq": "3-keto-steroid reductase", "tax_id": 559292, "disease": "polycystic ovary syndrome (Disease Ontology:DOID:11612); steroid inherited metabolic disorder (Disease Ontology:DOID:1701)", "pathway": " (sce:YLR100W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10535978;12119386;12842197;15716577;15995173;17330950;17563356;19779198;19795423;19823750;23749301;24374639;32597660;32679672;33491328;9169871", "class_list": "", "function": "3-keto-steroid reductase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:10535978, PubMed:12119386, PubMed:12842197, PubMed:15995173). ERG27 is a catalytic component of the C-4 demethylation complex that catalyze the reduction of the keto group on the C-3 (PubMed:10535978). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25. Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (PubMed:32679672)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Facilitates the association of ERG7 with lipid particles preventing its digestion in the endoplasmic reticulum and the lipid particles., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYA1", "ec_number_list": [ { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" } ], "go_molecular_function": "GO:0000253 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006696 ergosterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q12452-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12466-1", "uniprot_id": [ { "id": "TCB1_YEAST", "url": "https://www.uniprot.org/uniprot/Q12466", "type": "external" } ], "mass": 133576.0, "length": 1186, "protein_name": "Tricalbin-1", "gene_name": "TCB1", "organism": "Yeast", "refseq_name": "tricalbin", "refseq_ac": [ { "id": "NP_014729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014729", "type": "external" } ], "gene_names_uniprotkb": "TCB1; YOR3141c", "gene_names_refseq": "TCB1", "protein_names_uniprotkb": "Tricalbin-1", "protein_names_refseq": "tricalbin", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR086C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562095;14562106;15049706;15141306;16847258;18407956;19779198;21126336;22250200;23749301;24374639;32597660;33481703;33491328;34965436;9169874;9200815", "class_list": "", "function": "May play a role in membrane trafficking., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2E8", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008289 lipid binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0071561 nucleus-vacuole junction;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0090158 endoplasmic reticulum membrane organization;GO:0055091 phospholipid homeostasis;GO:0060304 regulation of phosphatidylinositol dephosphorylation;GO:0035621 ER to Golgi ceramide transport;GO:0061817 endoplasmic reticulum-plasma membrane tethering", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q12466-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12472-1", "uniprot_id": [ { "id": "YD21B_YEAST", "url": "https://www.uniprot.org/uniprot/Q12472", "type": "external" } ], "mass": 201965.0, "length": 1770, "protein_name": "Transposon Ty2-DR1 Gag-Pol polyprotein", "gene_name": "TY2B-DR1", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": [ { "id": "NP_058138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058138", "type": "external" } ], "gene_names_uniprotkb": "TY2B-DR1; YD9673.05c; YDRCTy2-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty2-DR1 Gag-Pol polyprotein; TY2A-TY2B; Transposon Ty2 TYA-TYB polyprotein; Transposon Ty917 protein A", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR034C-D)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15665377;16093660;24374639;2825192;9169867;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS19;Q04345;Q07166;Q7LIH4", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.26.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.4", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q12472-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12476-1", "uniprot_id": [ { "id": "AIR2_YEAST", "url": "https://www.uniprot.org/uniprot/Q12476", "type": "external" } ], "mass": 39344.0, "length": 344, "protein_name": "Protein AIR2", "gene_name": "AIR2", "organism": "Yeast", "refseq_name": "TRAMP complex RNA-binding subunit", "refseq_ac": [ { "id": "NP_010106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010106", "type": "external" } ], "gene_names_uniprotkb": "AIR2", "gene_names_refseq": "AIR2", "protein_names_uniprotkb": "Protein AIR2; Arginine methyltransferase-interacting RING finger protein 2", "protein_names_refseq": "TRAMP complex RNA-binding subunit", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL175C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10896665;14562095;14562106;15665377;15828860;15935758;15935759;17330950;17563356;18407956;19779198;19795423;19823750;20696927;20702584;21126336;21177495;22218487;23749301;24374639;32597660;33481703;33491328;9169867", "class_list": "", "function": "Component of the TRAMP (TRF4) complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Both complexes polyadenylate RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome. AIR2 also inhibits the methylation of NPL3 mediated by HMT1 through its interaction with HMT1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRH7", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0031499 TRAMP complex", "go_biological_process": "GO:0006400 tRNA modification;GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process;GO:0071038 TRAMP-dependent tRNA surveillance pathway;GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process;GO:0071037 nuclear polyadenylation-dependent snRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q12476-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12483-1", "uniprot_id": [ { "id": "SNF8_YEAST", "url": "https://www.uniprot.org/uniprot/Q12483", "type": "external" } ], "mass": 26954.0, "length": 233, "protein_name": "Vacuolar-sorting protein SNF8", "gene_name": "SNF8", "organism": "Yeast", "refseq_name": "ESCRT-II subunit protein SNF8", "refseq_ac": [ { "id": "NP_015323", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015323", "type": "external" } ], "gene_names_uniprotkb": "SNF8; VPS22", "gene_names_refseq": "SNF8; VPL14; VPS22", "protein_names_uniprotkb": "Vacuolar-sorting protein SNF8; ESCRT-II complex subunit VPS22; Vacuolar protein-sorting-associated protein 22", "protein_names_refseq": "ESCRT-II subunit protein SNF8", "tax_id": 559292, "disease": "developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YPL002C); (R-SCE-917729)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12194858;14562106;15329733;15469844;17322287;24374639;33491328;7785322;9169875", "class_list": "", "function": "Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W410", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0000814 ESCRT II complex", "go_biological_process": "GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006623 protein targeting to vacuole;GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:1904669 ATP export", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q12483-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12498-1", "uniprot_id": [ { "id": "PRM4_YEAST", "url": "https://www.uniprot.org/uniprot/Q12498", "type": "external" } ], "mass": 32012.0, "length": 284, "protein_name": "Pheromone-regulated membrane protein 4", "gene_name": "PRM4", "organism": "Yeast", "refseq_name": "pheromone-regulated protein PRM4", "refseq_ac": [ { "id": "NP_015169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015169", "type": "external" } ], "gene_names_uniprotkb": "PRM4; P2578", "gene_names_refseq": "PRM4", "protein_names_uniprotkb": "Pheromone-regulated membrane protein 4", "protein_names_refseq": "pheromone-regulated protein PRM4", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL156C)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11062271;24374639;8948103;9169875", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3L2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q12498-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12502-1", "uniprot_id": [ { "id": "LDB19_YEAST", "url": "https://www.uniprot.org/uniprot/Q12502", "type": "external" } ], "mass": 89826.0, "length": 818, "protein_name": "Protein LDB19", "gene_name": "LDB19", "organism": "Yeast", "refseq_name": "Ldb19p", "refseq_ac": [ { "id": "NP_014967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014967", "type": "external" } ], "gene_names_uniprotkb": "LDB19; O6152", "gene_names_refseq": "ART1; LDB19", "protein_names_uniprotkb": "Protein LDB19; Low dye-binding protein 19", "protein_names_refseq": "Ldb19p", "tax_id": 559292, "disease": "stomach cancer (Disease Ontology:DOID:10534); Reye syndrome (Disease Ontology:DOID:14525); glaucoma (Disease Ontology:DOID:1686); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YOR322C)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10407277;14557538;14562095;14562106;15993632;16278933;17330950;18407956;19684113;19779198;20702584;21126336;21177495;22118465;23749301;24374639;30610170;31618110;32597660;33229814;33481703;33491328;34965436;8896266;9169874", "class_list": "", "function": "May be involved in protein-linked oligosaccharide phosphorylation since the deletion reduces the negative charge of the cell surface. Involved in the resistance to EDTA, cadmium chloride, cycloheximide, 6-dimethylaminopurine, methyl caffeate, beta-chloro-L-alanine, caffeine and cerulenin., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 20, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 20, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 20, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 50, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 21, "binding_glycan_count": 0, "secondary_ac_list": "D6W320", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000138 Golgi trans cisterna", "go_biological_process": "GO:0002092 positive regulation of receptor internalization;GO:0033554 cellular response to stress;GO:0071230 cellular response to amino acid stimulus;GO:0070086 ubiquitin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "Q12502-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12508-1", "uniprot_id": [ { "id": "RMD5_YEAST", "url": "https://www.uniprot.org/uniprot/Q12508", "type": "external" } ], "mass": 49169.0, "length": 421, "protein_name": "E3 ubiquitin-protein ligase RMD5", "gene_name": "RMD5", "organism": "Yeast", "refseq_name": "ubiquitin-protein ligase RMD5", "refseq_ac": [ { "id": "NP_010541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010541", "type": "external" } ], "gene_names_uniprotkb": "RMD5; GID2; YD9320A.05c", "gene_names_refseq": "GID2; RMD5", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RMD5; 2.3.2.27; GID complex catalytic subunit 2; Glucose-induced degradation protein 2; Required for meiotic nuclear division protein 5; Sporulation protein RMD5", "protein_names_refseq": "ubiquitin-protein ligase RMD5", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR255C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12586695;12686616;16872538;17322287;18508925;22044534;22645139;24374639;28126757;31708416;33905682;38113892;9169867;9737955", "class_list": "", "function": "E3 ubiquitin-protein ligase component of the GID E3 ligase complex recruiting N termini and catalyzing ubiquitination of proteins targeted for degradation. GID E3 is regulated through assembly with interchangeable N-degron-binding substrate receptors induced by distinct environmental perturbations (PubMed:18508925, PubMed:31708416). Required for the adaptation to the presence of glucose in the growth medium; mediates in association with the substrate receptor VID24/GID4 the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616, PubMed:18508925, PubMed:31708416, PubMed:9737955). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1), malate dehydrogenase (MDH2), and other gluconeogenic enzymes (PubMed:12686616, PubMed:18508925, PubMed:22645139, PubMed:28126757, PubMed:9737955)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSN5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005829 cytosol;GO:0034657 GID complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0045721 negative regulation of gluconeogenesis;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q12508-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12517-1", "uniprot_id": [ { "id": "DCP1_YEAST", "url": "https://www.uniprot.org/uniprot/Q12517", "type": "external" } ], "mass": 26266.0, "length": 231, "protein_name": "mRNA-decapping enzyme subunit 1", "gene_name": "DCP1", "organism": "Yeast", "refseq_name": "Dcp1p", "refseq_ac": [ { "id": "NP_014492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014492", "type": "external" } ], "gene_names_uniprotkb": "DCP1", "gene_names_refseq": "DCP1; MRT2", "protein_names_uniprotkb": "mRNA-decapping enzyme subunit 1", "protein_names_refseq": "Dcp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL149W); (R-SCE-430039); (R-SCE-450385); (R-SCE-450513)", "pathway_count": 4, "publication_count": 31, "publication_id_list": "10075882;10101156;10409716;10508173;10564284;10761922;10900456;10944120;11139489;11741542;11780629;12032091;12054793;12554866;12730603;14562095;14562106;14758354;15024087;17322287;22814378;23749301;24374639;33481703;33491328;8553699;8757137;8816497;9169874;9482745;9482746", "class_list": "", "function": "Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body. DCP1 is activated by the DEAD-box helicase DHH1 and destabilizes the eIF-4F cap-binding complex from the mRNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1S0", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0098562 cytoplasmic side of membrane;GO:0098745 RNA decapping complex", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0006397 mRNA processing;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q12517-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12522-1", "uniprot_id": [ { "id": "IF6_YEAST", "url": "https://www.uniprot.org/uniprot/Q12522", "type": "external" } ], "mass": 26458.0, "length": 245, "protein_name": "Eukaryotic translation initiation factor 6", "gene_name": "TIF6", "organism": "Yeast", "refseq_name": "translation initiation factor 6", "refseq_ac": [ { "id": "NP_015341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015341", "type": "external" } ], "gene_names_uniprotkb": "TIF6; CDC95; LPZ15C", "gene_names_refseq": "CDC95; TIF6", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 6; eIF-6", "protein_names_refseq": "translation initiation factor 6", "tax_id": 559292, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YPR016C)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10085284;10206977;11101899;11238882;11779510;12917340;14562106;17322287;17330950;17353896;18256024;18407956;19779198;20356839;20702584;21126336;21177495;23749301;24374639;30516470;32597660;33481703;33491328;36804914;9169875;9891075", "class_list": "", "function": "Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by the GTPase RIA1/EFL1 and by SDO1. Also required for pre-rRNA processing., [UniProtKB, PubMed, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W426", "ec_number_list": [], "go_molecular_function": "GO:0003743 translation initiation factor activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0000054 ribosomal subunit export from nucleus;GO:0006364 rRNA processing;GO:0000460 maturation of 5.8S rRNA;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q12522-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q12734-1", "uniprot_id": [ { "id": "CSR2_YEAST", "url": "https://www.uniprot.org/uniprot/Q12734", "type": "external" } ], "mass": 124849.0, "length": 1121, "protein_name": "Transcription factor CSR2", "gene_name": "CSR2", "organism": "Yeast", "refseq_name": "Csr2p", "refseq_ac": [ { "id": "NP_015355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015355", "type": "external" } ], "gene_names_uniprotkb": "CSR2; MRG19; YP9367.10", "gene_names_refseq": "ART8; CSR2; MRG19", "protein_names_uniprotkb": "Transcription factor CSR2; CHS5 SPA2 rescue protein 2", "protein_names_refseq": "Csr2p", "tax_id": 559292, "disease": "stomach cancer (Disease Ontology:DOID:10534); Reye syndrome (Disease Ontology:DOID:14525); glaucoma (Disease Ontology:DOID:1686); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YPR030W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10660072;10679005;12444972;12872131;14574415;15632429;16336970;19779198;20489023;22814378;23749301;24374639;32597660;33481703;33491328;9169875", "class_list": "", "function": "Transcription factor involved in the regulation of fermentation and aerobic oxidation. Acts as a repressor of CYC1, which is involved in electron flow through the mitochondria under aerobic condition. Required for pseudohyphal formation upon nitrogen starvation. May be involved in viability at stationary phase and aging., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W440", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0070086 ubiquitin-dependent endocytosis;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q12734-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3E7Y6-1", "uniprot_id": [ { "id": "NBL1_YEAST", "url": "https://www.uniprot.org/uniprot/Q3E7Y6", "type": "external" } ], "mass": 8547.0, "length": 73, "protein_name": "N-terminal-borealin-like protein", "gene_name": "NBL1", "organism": "Yeast", "refseq_name": "borealin", "refseq_ac": [ { "id": "NP_976247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_976247", "type": "external" } ], "gene_names_uniprotkb": "NBL1", "gene_names_refseq": "NBL1", "protein_names_uniprotkb": "N-terminal-borealin-like protein", "protein_names_refseq": "borealin", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR199C-A)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12775844;19158380;24374639;8091229", "class_list": "", "function": "Component of the aurora kinase complex, also called chromosomal passenger complex (CPC), essential for chromosome segregation and metaphase chromosome alignment. Mediates the SLI15-BIR1 interaction within the CPC., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLE8", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005819 spindle;GO:0032133 chromosome passenger complex", "go_biological_process": "GO:0007059 chromosome segregation;GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint;GO:0031134 sister chromatid biorientation;GO:0051316 attachment of meiotic spindle microtubules to kinetochore", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3E7Y6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q92317-1", "uniprot_id": [ { "id": "NCB2_YEAST", "url": "https://www.uniprot.org/uniprot/Q92317", "type": "external" } ], "mass": 16650.0, "length": 146, "protein_name": "Negative cofactor 2 complex subunit beta", "gene_name": "NCB2", "organism": "Yeast", "refseq_name": "negative cofactor 2 transcription regulator complex subunit NCB2", "refseq_ac": [ { "id": "NP_010685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010685", "type": "external" } ], "gene_names_uniprotkb": "NCB2; YDR1", "gene_names_refseq": "NCB2; YDR1", "protein_names_uniprotkb": "Negative cofactor 2 complex subunit beta; NC2 complex subunit beta; Transcriptional repressor YDR1", "protein_names_refseq": "negative cofactor 2 transcription regulator complex subunit NCB2", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR397C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "11875433;12237409;12502746;14562095;14562106;17330950;17563356;18407956;19684113;19779198;20702584;23749301;24374639;32597660;33481703;33491328;33502312;8948634;9023340;9096360;9169867", "class_list": "", "function": "Component of the NC2 complex which represses RNA polymerase II transcription through binding to SPT15/TBP and thereby inhibiting the assembly of the preinitiation complex. The NC2 complex may also mediate transcriptional activation from TATA-driven promoters through association with SPT15/TBP., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT30;O00064;P87340;Q04176", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0046982 protein heterodimerization activity;GO:0003714 transcription corepressor activity;GO:0001046 core promoter sequence-specific DNA binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0017054 negative cofactor 2 complex", "go_biological_process": "GO:0017055 negative regulation of RNA polymerase II transcription preinitiation complex assembly;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q92317-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99181-1", "uniprot_id": [ { "id": "HSH49_YEAST", "url": "https://www.uniprot.org/uniprot/Q99181", "type": "external" } ], "mass": 24503.0, "length": 213, "protein_name": "Protein HSH49", "gene_name": "HSH49", "organism": "Yeast", "refseq_name": "U2 snRNP complex subunit HSH49", "refseq_ac": [ { "id": "NP_014964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014964", "type": "external" } ], "gene_names_uniprotkb": "HSH49; O6142", "gene_names_refseq": "HSH49", "protein_names_uniprotkb": "Protein HSH49", "protein_names_refseq": "U2 snRNP complex subunit HSH49", "tax_id": 559292, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); cervical cancer (Disease Ontology:DOID:4362); Nager acrofacial dysostosis (Disease Ontology:DOID:5768); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YOR319W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14517302;14562106;17322287;24374639;8896266;9169874", "class_list": "", "function": "Possible SF3b-like factor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W317", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005686 U2 snRNP;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:1903241 U2-type prespliceosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99181-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99207-1", "uniprot_id": [ { "id": "NOP14_YEAST", "url": "https://www.uniprot.org/uniprot/Q99207", "type": "external" } ], "mass": 94302.0, "length": 810, "protein_name": "Nucleolar complex protein 14", "gene_name": "NOP14", "organism": "Yeast", "refseq_name": "snoRNA-binding rRNA-processing protein NOP14", "refseq_ac": [ { "id": "NP_010133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010133", "type": "external" } ], "gene_names_uniprotkb": "NOP14; D1566; UTP2", "gene_names_refseq": "NOP14; UTP2", "protein_names_uniprotkb": "Nucleolar complex protein 14; U three protein 2; U3 small nucleolar RNA-associated protein 2; U3 snoRNA-associated protein 2", "protein_names_refseq": "snoRNA-binding rRNA-processing protein NOP14", "tax_id": 559292, "disease": "oligohydramnios (Disease Ontology:DOID:12215)", "pathway": " (sce:YDL148C); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11694595;12068309;12446671;21177495;22814378;24374639;33481703;33491328;8972581;9169867", "class_list": "", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRK0", "ec_number_list": [], "go_molecular_function": "GO:0034511 U3 snoRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006364 rRNA processing;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99207-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99260-1", "uniprot_id": [ { "id": "YPT6_YEAST", "url": "https://www.uniprot.org/uniprot/Q99260", "type": "external" } ], "mass": 24413.0, "length": 215, "protein_name": "GTP-binding protein YPT6", "gene_name": "YPT6", "organism": "Yeast", "refseq_name": "Rab family GTPase YPT6", "refseq_ac": [ { "id": "NP_013363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013363", "type": "external" } ], "gene_names_uniprotkb": "YPT6; L8479.11", "gene_names_refseq": "YPT6", "protein_names_uniprotkb": "GTP-binding protein YPT6", "protein_names_refseq": "Rab family GTPase YPT6", "tax_id": 559292, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (sce:YLR262C); (R-SCE-6798695); (R-SCE-6811440); (R-SCE-8873719); (R-SCE-8876198)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "11785952;11943201;14562106;17322287;24374639;33491328;9169871", "class_list": "", "function": "Protein transport. Might participate in post-Golgi transport., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYQ8", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016236 macroautophagy;GO:0034605 cellular response to heat;GO:0034497 protein localization to phagophore assembly site;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99260-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99325-1", "uniprot_id": [ { "id": "ATG40_YEAST", "url": "https://www.uniprot.org/uniprot/Q99325", "type": "external" } ], "mass": 29693.0, "length": 256, "protein_name": "Autophagy-related protein 40", "gene_name": "ATG40", "organism": "Yeast", "refseq_name": "Atg40p", "refseq_ac": [ { "id": "NP_014795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014795", "type": "external" } ], "gene_names_uniprotkb": "ATG40; O3536", "gene_names_refseq": "ATG40", "protein_names_uniprotkb": "Autophagy-related protein 40", "protein_names_refseq": "Atg40p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR152C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12788058;14562106;16847258;17322287;24374639;26040717;32620754;9046089;9169874", "class_list": "", "function": "Acts as a receptor for reticulophagy. Directs autophagic sequestration of folded tubules/sheets derived from the cortical endoplasmic reticulum (cER) and the cytoplasmic endoplasmic reticulum (cytoER) into autophagosomes. Is not required for the cytoplasm-to-vacuole targeting pathway, mitophagy, pexophagy, and non-selective autophagy., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2K9", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0034045 phagophore assembly site membrane;GO:0032541 cortical endoplasmic reticulum", "go_biological_process": "GO:0006995 cellular response to nitrogen starvation;GO:0061709 reticulophagy", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99325-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99359-1", "uniprot_id": [ { "id": "RAD61_YEAST", "url": "https://www.uniprot.org/uniprot/Q99359", "type": "external" } ], "mass": 74722.0, "length": 647, "protein_name": "Protein RAD61", "gene_name": "RAD61", "organism": "Yeast", "refseq_name": "Rad61p", "refseq_ac": [ { "id": "NP_010297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010297", "type": "external" } ], "gene_names_uniprotkb": "RAD61; PZB647", "gene_names_refseq": "RAD61; WPL1", "protein_names_uniprotkb": "Protein RAD61; Radiation sensitivity protein 61", "protein_names_refseq": "Rad61p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR014W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12816519;14562095;14562106;24374639;30605471;33491328;8896275;9169867", "class_list": "", "function": "Involved in resistance to ionizing radiation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS00", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1902340 negative regulation of chromosome condensation;GO:0042138 meiotic DNA double-strand break formation;GO:0007064 mitotic sister chromatid cohesion;GO:0140588 chromatin looping;GO:0034183 negative regulation of maintenance of mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99359-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9URQ3-1", "uniprot_id": [ { "id": "ADAT3_YEAST", "url": "https://www.uniprot.org/uniprot/Q9URQ3", "type": "external" } ], "mass": 37107.0, "length": 322, "protein_name": "tRNA-specific adenosine-34 deaminase regulatory subunit TAD3", "gene_name": "TAD3", "organism": "Yeast", "refseq_name": "Tad3p", "refseq_ac": [ { "id": "NP_013420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013420", "type": "external" } ], "gene_names_uniprotkb": "TAD3", "gene_names_refseq": "TAD3", "protein_names_uniprotkb": "tRNA-specific adenosine-34 deaminase regulatory subunit TAD3", "protein_names_refseq": "Tad3p", "tax_id": 559292, "disease": "neurodevelopmental disorder with brain abnormalities, poor growth, and dysmorphic facies (Disease Ontology:DOID:0081099)", "pathway": " (sce:YLR316C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10550050;14562095;14562106;24374639;33272269;36164978;8893855;9169871", "class_list": "", "function": "Non-catalytic subunit of the tRNA-specific adenosine-34 deaminase complex, composed of the TAD2 catalytic subunit and the TAD3 regulatory subunit, which deaminates adenosine-34 (the first, also called wobble position of the anticodon) to inosine in many tRNAs. Inosine-34 allows the decoding of 3 different nucleotides at the third position of mRNA codons, as inosine is able to pair with U, C, and A., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYW0;O13552", "ec_number_list": [], "go_molecular_function": "GO:0008251 tRNA-specific adenosine deaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome", "go_biological_process": "GO:0002100 tRNA wobble adenosine to inosine editing;GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9URQ3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O13539-1", "uniprot_id": [ { "id": "THP2_YEAST", "url": "https://www.uniprot.org/uniprot/O13539", "type": "external" } ], "mass": 30299.0, "length": 261, "protein_name": "THO complex subunit THP2", "gene_name": "THP2", "organism": "Yeast", "refseq_name": "Thp2p", "refseq_ac": [ { "id": "NP_012037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012037", "type": "external" } ], "gene_names_uniprotkb": "THP2", "gene_names_refseq": "THP2", "protein_names_uniprotkb": "THO complex subunit THP2", "protein_names_refseq": "Thp2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR167W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11060033;11979277;12093753;12871933;14527416;14562095;14562106;15192704;18407956;24374639;33481703;33491328;8091229", "class_list": "", "function": "Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLB6", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0000445 THO complex part of transcription export complex;GO:0000446 nucleoplasmic THO complex", "go_biological_process": "GO:0006310 DNA recombination;GO:0006406 mRNA export from nucleus;GO:0006368 transcription elongation by RNA polymerase II;GO:0097185 cellular response to azide;GO:0034063 stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O13539-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10963-1", "uniprot_id": [ { "id": "PCKA_YEAST", "url": "https://www.uniprot.org/uniprot/P10963", "type": "external" } ], "mass": 60983.0, "length": 549, "protein_name": "Phosphoenolpyruvate carboxykinase (ATP)", "gene_name": "PCK1", "organism": "Yeast", "refseq_name": "phosphoenolpyruvate carboxykinase PCK1", "refseq_ac": [ { "id": "NP_013023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013023", "type": "external" } ], "gene_names_uniprotkb": "PCK1; PEPC; PPC1", "gene_names_refseq": "JPM2; PCK1; PPC1", "protein_names_uniprotkb": "Phosphoenolpyruvate carboxykinase (ATP); 4.1.1.49", "protein_names_refseq": "phosphoenolpyruvate carboxykinase PCK1", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR097W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1540632;17322287;24374639;3060853;33491328;7756267;8196765", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXF8;E9P963", "ec_number_list": [ { "id": "4.1.1.49", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.49", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004612 phosphoenolpyruvate carboxykinase (ATP) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006094 gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P10963-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23248-1", "uniprot_id": [ { "id": "RS3A2_YEAST", "url": "https://www.uniprot.org/uniprot/P23248", "type": "external" } ], "mass": 28812.0, "length": 255, "protein_name": "Small ribosomal subunit protein eS1B", "gene_name": "RPS1B", "organism": "Yeast", "refseq_name": "40S ribosomal protein eS1 RPS1B", "refseq_ac": [ { "id": "NP_013648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013648", "type": "external" } ], "gene_names_uniprotkb": "RPS1B; PLC2; RPS10B", "gene_names_refseq": "PLC2; RP10B; RPS1B", "protein_names_uniprotkb": "Small ribosomal subunit protein eS1B; 40S ribosomal protein S1-B; RP10B", "protein_names_refseq": "40S ribosomal protein eS1 RPS1B", "tax_id": 559292, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (sce:YML063W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 12, "publication_count": 25, "publication_id_list": "14562095;14562106;1544921;15665377;17287358;17322287;17330950;17563356;18407956;19779198;19795423;19823750;2017143;20702584;22096102;22106047;23749301;24374639;24524803;30516470;32597660;33481703;33491328;9169872;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZB0", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0030686 90S preribosome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0002181 cytoplasmic translation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P23248-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23624-1", "uniprot_id": [ { "id": "SPO13_YEAST", "url": "https://www.uniprot.org/uniprot/P23624", "type": "external" } ], "mass": 33295.0, "length": 291, "protein_name": "Meiosis-specific protein SPO13", "gene_name": "SPO13", "organism": "Yeast", "refseq_name": "Spo13p", "refseq_ac": [ { "id": "NP_011878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011878", "type": "external" } ], "gene_names_uniprotkb": "SPO13", "gene_names_refseq": "SPO13", "protein_names_uniprotkb": "Meiosis-specific protein SPO13; Sporulation-specific protein 13", "protein_names_refseq": "Spo13p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR014W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17322287;21126336;2123556;24374639;25533956;8091229", "class_list": "", "function": "Required for meiosis I segmentation (PubMed:2123556). Probably acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (PubMed:25533956)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKV9", "ec_number_list": [], "go_molecular_function": "GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0072687 meiotic spindle;GO:0000779 condensed chromosome, centromeric region", "go_biological_process": "GO:0071459 protein localization to chromosome, centromeric region;GO:0051321 meiotic cell cycle;GO:0045876 positive regulation of sister chromatid cohesion;GO:0051177 meiotic sister chromatid cohesion;GO:0030435 sporulation resulting in formation of a cellular spore", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P23624-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28004-1", "uniprot_id": [ { "id": "PRP45_YEAST", "url": "https://www.uniprot.org/uniprot/P28004", "type": "external" } ], "mass": 42483.0, "length": 379, "protein_name": "Pre-mRNA-processing protein 45", "gene_name": "PRP45", "organism": "Yeast", "refseq_name": "mRNA splicing protein PRP45", "refseq_ac": [ { "id": "NP_009370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009370", "type": "external" } ], "gene_names_uniprotkb": "PRP45; FUN20", "gene_names_refseq": "FUN20; PRP45", "protein_names_uniprotkb": "Pre-mRNA-processing protein 45", "protein_names_refseq": "mRNA splicing protein PRP45", "tax_id": 559292, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); breast carcinoma (Disease Ontology:DOID:3459); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YAL032C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11884590;12359070;12554883;14562095;14562106;14690591;1583694;23749301;24374639;33491328;7731988", "class_list": "", "function": "Involved in pre-mRNA splicing. Associated with the spliceosome throughout the splicing reactions, until after the second catalytic step., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPI6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0071014 post-mRNA release spliceosomal complex;GO:0071006 U2-type catalytic step 1 spliceosome;GO:0071007 U2-type catalytic step 2 spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000350 generation of catalytic spliceosome for second transesterification step", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P28004-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28005-1", "uniprot_id": [ { "id": "POP5_YEAST", "url": "https://www.uniprot.org/uniprot/P28005", "type": "external" } ], "mass": 19574.0, "length": 173, "protein_name": "Ribonuclease P/MRP protein subunit POP5", "gene_name": "POP5", "organism": "Yeast", "refseq_name": "RNA-binding protein POP5", "refseq_ac": [ { "id": "NP_009369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009369", "type": "external" } ], "gene_names_uniprotkb": "POP5; FUN53", "gene_names_refseq": "FUN53; POP5", "protein_names_uniprotkb": "Ribonuclease P/MRP protein subunit POP5; 3.1.26.5; RNA-processing protein POP5; RNase P/MRP 19.6 kDa subunit", "protein_names_refseq": "RNA-binding protein POP5", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL033W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;14690591;15637077;1583694;24374639;7731988;9620854", "class_list": "", "function": "Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPI5", "ec_number_list": [], "go_molecular_function": "GO:0000171 ribonuclease MRP activity;GO:0003723 RNA binding;GO:0004526 ribonuclease P activity;GO:0033204 ribonuclease P RNA binding", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0005737 cytoplasm;GO:0000172 ribonuclease MRP complex", "go_biological_process": "GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent;GO:0008033 tRNA processing;GO:0006364 rRNA processing;GO:0000460 maturation of 5.8S rRNA;GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P28005-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28007-1", "uniprot_id": [ { "id": "GAR1_YEAST", "url": "https://www.uniprot.org/uniprot/P28007", "type": "external" } ], "mass": 21480.0, "length": 205, "protein_name": "H/ACA ribonucleoprotein complex subunit GAR1", "gene_name": "GAR1", "organism": "Yeast", "refseq_name": "H/ACA snoRNP pseudouridylase subunit GAR1", "refseq_ac": [ { "id": "NP_011957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011957", "type": "external" } ], "gene_names_uniprotkb": "GAR1", "gene_names_refseq": "GAR1", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit GAR1; Glycine/arginine-rich protein 1; snoRNP protein GAR1", "protein_names_refseq": "H/ACA snoRNP pseudouridylase subunit GAR1", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR089C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "12756332;14562095;14562106;1531632;15388873;17322287;21131909;22085967;22106047;22117216;24374639;26046779;26081071;33491328;33856219;8091229;9303321;9556561;9843512", "class_list": "", "function": "Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis (PubMed:9303321, PubMed:9843512). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:9303321, PubMed:9843512). Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (PubMed:9843512). The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs (PubMed:21131909). The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA (PubMed:21131909). Essential for growth (PubMed:9303321)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL41", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0034513 box H/ACA snoRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0031429 box H/ACA snoRNP complex", "go_biological_process": "GO:0031120 snRNA pseudouridine synthesis;GO:0000454 snoRNA guided rRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P28007-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28240-1", "uniprot_id": [ { "id": "ACEA_YEAST", "url": "https://www.uniprot.org/uniprot/P28240", "type": "external" } ], "mass": 62409.0, "length": 557, "protein_name": "Isocitrate lyase", "gene_name": "ICL1", "organism": "Yeast", "refseq_name": "isocitrate lyase 1", "refseq_ac": [ { "id": "NP_010987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010987", "type": "external" } ], "gene_names_uniprotkb": "ICL1", "gene_names_refseq": "ICL1", "protein_names_uniprotkb": "Isocitrate lyase; 4.1.3.1; 4.1.3.30; ICL; MICA; Methylisocitrate lyase; Threo-D(S)-isocitrate glyoxylate-lyase", "protein_names_refseq": "isocitrate lyase 1", "tax_id": 559292, "disease": "", "pathway": " (sce:YER065C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10540293;11452311;1551398;17428308;17651441;20457600;21246628;22876324;23159490;24062879;24374639;24520859;3059712;3076186;4259654;8319292;8641464;8870676;8923733;9169868;9370278;9425123", "class_list": "", "function": "Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Also acts on 2-methylisocitrate., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLX0", "ec_number_list": [ { "id": "4.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.1", "type": "external" }, { "id": "4.1.3.30", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.30", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004451 isocitrate lyase activity;GO:0046421 methylisocitrate lyase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005773 vacuole", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006097 glyoxylate cycle", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P28240-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28241-1", "uniprot_id": [ { "id": "IDH2_YEAST", "url": "https://www.uniprot.org/uniprot/P28241", "type": "external" } ], "mass": 39739.0, "length": 369, "protein_name": "Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial", "gene_name": "IDH2", "organism": "Yeast", "refseq_name": "isocitrate dehydrogenase (NAD(+)) IDH2", "refseq_ac": [ { "id": "NP_014779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014779", "type": "external" } ], "gene_names_uniprotkb": "IDH2; O3326; YOR3326W", "gene_names_refseq": "IDH2", "protein_names_uniprotkb": "Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial; 1.1.1.41; Isocitric dehydrogenase; NAD(+)-specific ICDH", "protein_names_refseq": "isocitrate dehydrogenase (NAD(+)) IDH2", "tax_id": 559292, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); retinitis pigmentosa 90 (Disease Ontology:DOID:0112147); neuromuscular junction disease (Disease Ontology:DOID:439)", "pathway": " (sce:YOR136W); (R-SCE-71403)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "11502169;14562106;17761666;18407956;1939242;19779198;21126336;2198251;24374639;32597660;33229814;33481703;33491328;7505425;8904341;9169874;9200815", "class_list": "", "function": "Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W2J3", "ec_number_list": [ { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003723 RNA binding;GO:0051287 NAD binding;GO:0004449 isocitrate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045242 isocitrate dehydrogenase complex (NAD+)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006102 isocitrate metabolic process;GO:0006537 glutamate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P28241-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28263-1", "uniprot_id": [ { "id": "UBC8_YEAST", "url": "https://www.uniprot.org/uniprot/P28263", "type": "external" } ], "mass": 24633.0, "length": 218, "protein_name": "Ubiquitin-conjugating enzyme E2-24 kDa", "gene_name": "UBC8", "organism": "Yeast", "refseq_name": "E2 ubiquitin-conjugating protein UBC8", "refseq_ac": [ { "id": "NP_010904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010904", "type": "external" } ], "gene_names_uniprotkb": "UBC8; GID3", "gene_names_refseq": "GID3; UBC8", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2-24 kDa; 2.3.2.23; E2 ubiquitin-conjugating enzyme 8; Glucose-induced degradation protein 3; Ubiquitin carrier protein; Ubiquitin-protein ligase", "protein_names_refseq": "E2 ubiquitin-conjugating protein UBC8", "tax_id": 559292, "disease": "viral infectious disease (Disease Ontology:DOID:934)", "pathway": " (sce:YEL012W); (R-SCE-983168)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10811607;12686616;14562106;1869573;24374639;28126757;33491328;8132613;9169868;9737955", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity) (PubMed:1869573). Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:10811607, PubMed:12686616, PubMed:9737955). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:10811607, PubMed:12686616, PubMed:28126757, PubMed:9737955)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLN7", "ec_number_list": [ { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "1.14.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0045721 negative regulation of gluconeogenesis;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070096 mitochondrial outer membrane translocase complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P28263-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28272-1", "uniprot_id": [ { "id": "PYRD_YEAST", "url": "https://www.uniprot.org/uniprot/P28272", "type": "external" } ], "mass": 34801.0, "length": 314, "protein_name": "Dihydroorotate dehydrogenase (fumarate)", "gene_name": "URA1", "organism": "Yeast", "refseq_name": "dihydroorotate dehydrogenase", "refseq_ac": [ { "id": "NP_012706", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012706", "type": "external" } ], "gene_names_uniprotkb": "URA1", "gene_names_refseq": "URA1", "protein_names_uniprotkb": "Dihydroorotate dehydrogenase (fumarate); 1.3.98.1; DHODase; DHOD; DHOdehase; Dihydroorotate oxidase", "protein_names_refseq": "dihydroorotate dehydrogenase", "tax_id": 559292, "disease": "postaxial acrofacial dysostosis (Disease Ontology:DOID:0111259)", "pathway": " (sce:YKL216W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10871048;1409592;14562106;15014982;15087486;1511880;15196933;17617217;21126336;22106047;24374639;32597660;33481703;33491328;7941750;8196765", "class_list": "", "function": "Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro. Does not use oxaloacetate or NAD or NADP as electron acceptors., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWY7;Q2XN75;Q70DC7", "ec_number_list": [ { "id": "1.3.98.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.98.1", "type": "external" } ], "go_molecular_function": "GO:0004152 dihydroorotate dehydrogenase activity;GO:1990663 dihydroorotate dehydrogenase (fumarate) activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0044205 'de novo' UMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P28272-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28274-1", "uniprot_id": [ { "id": "URA7_YEAST", "url": "https://www.uniprot.org/uniprot/P28274", "type": "external" } ], "mass": 64710.0, "length": 579, "protein_name": "CTP synthase 1", "gene_name": "URA7", "organism": "Yeast", "refseq_name": "CTP synthase URA7", "refseq_ac": [ { "id": "NP_009514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009514", "type": "external" } ], "gene_names_uniprotkb": "URA7; YBL0410", "gene_names_refseq": "URA7", "protein_names_uniprotkb": "CTP synthase 1; 6.3.4.2; CTP synthetase 1; UTP--ammonia ligase 1", "protein_names_refseq": "CTP synthase URA7", "tax_id": 559292, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); immunodeficiency 24 (Disease Ontology:DOID:0111938); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YBL039C); (R-SCE-499943)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10393561;12670958;12709422;12872131;14562106;1753946;19779198;21126336;24374639;33481703;33491328;7813418;7871888;8075080", "class_list": "", "function": "Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPW0", "ec_number_list": [ { "id": "6.3.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0003883 CTP synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0097268 cytoophidium;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0008654 phospholipid biosynthetic process;GO:0044210 'de novo' CTP biosynthetic process;GO:0006241 CTP biosynthetic process;GO:0019856 pyrimidine nucleobase biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P28274-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28319-1", "uniprot_id": [ { "id": "CWP1_YEAST", "url": "https://www.uniprot.org/uniprot/P28319", "type": "external" } ], "mass": 24268.0, "length": 239, "protein_name": "Cell wall protein CWP1", "gene_name": "CWP1", "organism": "Yeast", "refseq_name": "Cwp1p", "refseq_ac": [ { "id": "NP_012827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012827", "type": "external" } ], "gene_names_uniprotkb": "CWP1; YJU1; YKL443", "gene_names_refseq": "CWP1; YJU1", "protein_names_uniprotkb": "Cell wall protein CWP1; Glycoprotein GP40", "protein_names_refseq": "Cwp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL096W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10209754;10594829;11016834;11136466;11292809;15087486;15781460;1626433;16672383;17617218;22218487;24374639;31870255;33491328;7768807;8196765;8256524;8543563;8724141", "class_list": "", "function": "Component of the cell wall., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXJ2;Q70DB4;Q70DB5", "ec_number_list": [], "go_molecular_function": "GO:0005199 structural constituent of cell wall", "go_cellular_component": "GO:0071597 cellular birth scar;GO:0000324 fungal-type vacuole;GO:0005628 prospore membrane;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0031505 fungal-type cell wall organization;GO:0032120 ascospore-type prospore membrane formation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P28319-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28320-1", "uniprot_id": [ { "id": "YJU2_YEAST", "url": "https://www.uniprot.org/uniprot/P28320", "type": "external" } ], "mass": 32312.0, "length": 278, "protein_name": "Splicing factor YJU2", "gene_name": "YJU2", "organism": "Yeast", "refseq_name": "mRNA splicing protein YJU2", "refseq_ac": [ { "id": "NP_012828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012828", "type": "external" } ], "gene_names_uniprotkb": "YJU2; CWC16; YKL442", "gene_names_refseq": "CWC16; YJU2", "protein_names_uniprotkb": "Splicing factor YJU2", "protein_names_refseq": "mRNA splicing protein YJU2", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL095W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11884590;14562095;14562106;14690591;1626433;19935684;23438600;24374639;27445308;27459055;29146871;8196765;8256524", "class_list": "", "function": "Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA (PubMed:19935684, PubMed:27445308, PubMed:27459055, PubMed:29146871). Plays a role (via N-terminus) in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (PubMed:23438600, PubMed:27459055). Further stabilizes spliceosome conformation for 3'-splice site docking (via C-terminus) promoting exon ligation (PubMed:29146871)., [UniProtKB, PubMed, HAMAP, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXJ3", "ec_number_list": [], "go_molecular_function": "GO:0030620 U2 snRNA binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071006 U2-type catalytic step 1 spliceosome;GO:0071007 U2-type catalytic step 2 spliceosome", "go_biological_process": "GO:0000349 generation of catalytic spliceosome for first transesterification step;GO:0000398 mRNA splicing, via spliceosome;GO:0000350 generation of catalytic spliceosome for second transesterification step;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P28320-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28321-1", "uniprot_id": [ { "id": "MGLL_YEAST", "url": "https://www.uniprot.org/uniprot/P28321", "type": "external" } ], "mass": 35563.0, "length": 313, "protein_name": "Monoglyceride lipase", "gene_name": "YJU3", "organism": "Yeast", "refseq_name": "acylglycerol lipase", "refseq_ac": [ { "id": "NP_012829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012829", "type": "external" } ], "gene_names_uniprotkb": "YJU3; YKL441", "gene_names_refseq": "YJU3", "protein_names_uniprotkb": "Monoglyceride lipase; 3.1.1.23; FAEE hydrolase; Fatty acid ethyl ester hydrolase; MAG hydrolase; MAG lipase; MAGL; MGH; MGL; Monoacylglycerol hydrolase; Monoacylglycerol lipase; Serine hydrolase YJU3", "protein_names_refseq": "acylglycerol lipase", "tax_id": 559292, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); alcohol use disorder (Disease Ontology:DOID:1574); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (sce:YKL094W); (R-SCE-1482883); (R-SCE-426048)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10515935;11914276;14562095;14562106;14645503;1626433;16407407;19529773;20554061;21820081;24374639;24868093;26869448;27036938;33491328;8196765;8256524", "class_list": "", "function": "Converts monoacylglycerides (MAG) to free fatty acids and glycerol (PubMed:20554061). Has a strong preference for monounsaturated monoglycerides (PubMed:26869448). Required for efficient degradation of MAG, short-lived intermediates of glycerolipid metabolism which may also function as lipid signaling molecules. Controls inactivation of the signaling lipid N-palmitoylethanolamine (PEA) (PubMed:19529773). Involved in fatty acid ethyl ester (FAEE) catabolism. FAEEs are non-oxidative metabolites of ethanol that are transiently incorporated into lipid droplets (LDs). Their mobilization by LD-resident FAEE hydrolases facilitates a controlled metabolism of these potentially toxic lipid metabolites (PubMed:27036938)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXJ4", "ec_number_list": [ { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" } ], "go_molecular_function": "GO:0047372 monoacylglycerol lipase activity;GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0019433 triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P28321-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28496-1", "uniprot_id": [ { "id": "LAC1_YEAST", "url": "https://www.uniprot.org/uniprot/P28496", "type": "external" } ], "mass": 48992.0, "length": 418, "protein_name": "Ceramide synthase LAC1", "gene_name": "LAC1", "organism": "Yeast", "refseq_name": "sphingosine N-acyltransferase LAC1", "refseq_ac": [ { "id": "NP_012917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012917", "type": "external" } ], "gene_names_uniprotkb": "LAC1; DGT1; YKL156", "gene_names_refseq": "DGT1; LAC1", "protein_names_uniprotkb": "Ceramide synthase LAC1; 2.3.1.297; Very-long-chain ceramide synthase LAC1", "protein_names_refseq": "sphingosine N-acyltransferase LAC1", "tax_id": 559292, "disease": "autosomal recessive congenital ichthyosis 9 (Disease Ontology:DOID:0060718); progressive myoclonus epilepsy 8 (Disease Ontology:DOID:0111451)", "pathway": " (sce:YKL008C); (R-SCE-1660661)", "pathway_count": 2, "publication_count": 28, "publication_id_list": "10198056;11387200;11694577;12151215;1447293;14562095;14562106;15302821;15692566;16756512;16847258;19684113;22218487;22814378;23749301;24374639;24909858;26726837;31164445;32597660;33481703;33491328;37953642;38964337;39490931;39528796;8196765;8488728", "class_list": "", "function": "Component of the ceramide synthase complex that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward hexacosanoyl-CoA (C26:0-CoA) (PubMed:11694577, PubMed:15692566, PubMed:37953642, PubMed:39528796). N-acylates sphinganine and phytosphingosine bases to form dihydroceramides and phytoceramides, respectively (PubMed:11694577, PubMed:15692566). Redundant with LAG1 (PubMed:39528796). Facilitates ER-to-Golgi transport of GPI-anchored proteins. Has a lower affinity for phytosphingosine (PHS) than dihydrosphingosine (DHS); PHS is required for the synthesis of phytoceramides and the formation of nuclear envelopes (PubMed:31164445). Along with LAG1, plays a role in pheromone-induced MAP kinase-activation of mating and formation of diploid cells (PubMed:26726837). May also play a role, together with LAG1, in the polarized membrane distribution of phosphatidylinositol 4,5 biphosphate required for STE5 localization to the plasma membrane (PubMed:26726837)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 28, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VXS8", "ec_number_list": [ { "id": "2.3.1.297", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.297", "type": "external" } ], "go_molecular_function": "GO:0050291 sphingosine N-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0034399 nuclear periphery;GO:0061576 acyl-CoA ceramide synthase complex", "go_biological_process": "GO:0046513 ceramide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P28496-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28627-1", "uniprot_id": [ { "id": "IMP1_YEAST", "url": "https://www.uniprot.org/uniprot/P28627", "type": "external" } ], "mass": 21433.0, "length": 190, "protein_name": "Mitochondrial inner membrane protease subunit 1", "gene_name": "IMP1", "organism": "Yeast", "refseq_name": "endopeptidase catalytic subunit IMP1", "refseq_ac": [ { "id": "NP_013870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013870", "type": "external" } ], "gene_names_uniprotkb": "IMP1; PET2858; YM9375.20C", "gene_names_refseq": "IMP1", "protein_names_uniprotkb": "Mitochondrial inner membrane protease subunit 1; 3.4.21.-", "protein_names_refseq": "endopeptidase catalytic subunit IMP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR150C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10608835;15118906;17322287;1886606;24374639;8132591;9169872", "class_list": "", "function": "Catalytic component of the mitochondrial inner membrane peptidase (IMP) complex. IMP catalyzes the removal of signal peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. The two catalytic IMP subunits seem to have non-overlapping substrate specificities. IMP1 substrates include nuclear encoded CYB2, mitochondrially encoded COX2, NADH-cytochrome b5 reductase and GUT2., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZX2;E9P8W1", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0042720 mitochondrial inner membrane peptidase complex;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006627 protein processing involved in protein targeting to mitochondrion;GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P28627-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28708-1", "uniprot_id": [ { "id": "PRR1_YEAST", "url": "https://www.uniprot.org/uniprot/P28708", "type": "external" } ], "mass": 58956.0, "length": 518, "protein_name": "Serine/threonine-protein kinase PRR1", "gene_name": "PRR1", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase PRR1", "refseq_ac": [ { "id": "NP_012806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012806", "type": "external" } ], "gene_names_uniprotkb": "PRR1; YKL516", "gene_names_refseq": "PRR1", "protein_names_uniprotkb": "Serine/threonine-protein kinase PRR1; 2.7.11.1; Pheromone response regulator 1", "protein_names_refseq": "serine/threonine protein kinase PRR1", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL116C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "11062466;11337509;14562095;14562106;1561835;15665377;16319894;17330950;18407956;19684113;19779198;20489023;21177495;22218487;22814378;23749301;24374639;27821475;32597660;33481703;33491328;8196765", "class_list": "", "function": "Protein kinase that functions as a regulator in the pheromone-induced mating pathway downstream of mitogen-activated protein kinase (MAPK) FUS3. Diminishes transcriptional induction of genes in response to pheromone signaling., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXH3", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005938 cell cortex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0019236 response to pheromone;GO:0031138 negative regulation of conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P28708-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28742-1", "uniprot_id": [ { "id": "KIP1_YEAST", "url": "https://www.uniprot.org/uniprot/P28742", "type": "external" } ], "mass": 125795.0, "length": 1111, "protein_name": "Kinesin-like protein KIP1", "gene_name": "KIP1", "organism": "Yeast", "refseq_name": "Kip1p", "refseq_ac": [ { "id": "NP_009490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009490", "type": "external" } ], "gene_names_uniprotkb": "KIP1; CIN9; YBL0504; YBL0521", "gene_names_refseq": "CIN9; KIP1", "protein_names_uniprotkb": "Kinesin-like protein KIP1; Chromosome instability protein 9", "protein_names_refseq": "Kip1p", "tax_id": 559292, "disease": "microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (Disease Ontology:DOID:0060349)", "pathway": " (sce:YBL063W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562106;1618910;1643659;17287358;19779198;20463882;23749301;24374639;32597660;33481703;33491328;7813418;8154187", "class_list": "", "function": "Required for assembly of the mitotic spindle. Interacts with spindle microtubules to produce an outwardly directed force acting upon the poles. Following spindle assembly, CIN8 and KIP1 apparently act to oppose a force that draws separated poles back together. This force seems to be mediate by KAR3., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPT7", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0003777 microtubule motor activity;GO:0008574 plus-end-directed microtubule motor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005871 kinesin complex;GO:0000776 kinetochore;GO:0005876 spindle microtubule;GO:0072686 mitotic spindle", "go_biological_process": "GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0007018 microtubule-based movement;GO:0007019 microtubule depolymerization;GO:0000070 mitotic sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P28742-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28743-1", "uniprot_id": [ { "id": "KIP2_YEAST", "url": "https://www.uniprot.org/uniprot/P28743", "type": "external" } ], "mass": 78378.0, "length": 706, "protein_name": "Kinesin-like protein KIP2", "gene_name": "KIP2", "organism": "Yeast", "refseq_name": "Kip2p", "refseq_ac": [ { "id": "NP_015170", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015170", "type": "external" } ], "gene_names_uniprotkb": "KIP2; P2581", "gene_names_refseq": "KIP2", "protein_names_uniprotkb": "Kinesin-like protein KIP2", "protein_names_refseq": "Kip2p", "tax_id": 559292, "disease": "primary autosomal recessive microcephaly 13 (Disease Ontology:DOID:0070283)", "pathway": " (sce:YPL155C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562106;1618910;17563356;18407956;19779198;21126336;21177495;23749301;24374639;26395399;31490122;32597660;33229814;33481703;33491328;8948103;9169875", "class_list": "", "function": "Required for assembly of the mitotic spindle., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W3L3", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0015631 tubulin binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:1903754 cortical microtubule plus-end;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005874 microtubule;GO:0005871 kinesin complex", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0051301 cell division;GO:0007018 microtubule-based movement;GO:0007026 negative regulation of microtubule depolymerization;GO:0030473 nuclear migration along microtubule", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P28743-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28795-1", "uniprot_id": [ { "id": "PEX3_YEAST", "url": "https://www.uniprot.org/uniprot/P28795", "type": "external" } ], "mass": 50676.0, "length": 441, "protein_name": "Peroxisomal biogenesis factor 3", "gene_name": "PEX3", "organism": "Yeast", "refseq_name": "Pex3p", "refseq_ac": [ { "id": "NP_010616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010616", "type": "external" } ], "gene_names_uniprotkb": "PEX3; D9798.15; PAS3", "gene_names_refseq": "PAS3; PEX3", "protein_names_uniprotkb": "Peroxisomal biogenesis factor 3; Peroxin-3", "protein_names_refseq": "Pex3p", "tax_id": 559292, "disease": "peroxisome biogenesis disorder 10A (Disease Ontology:DOID:0080484); Peroxisome biogenesis disorder 10B (Disease Ontology:DOID:0081440); Zellweger syndrome (Disease Ontology:DOID:905)", "pathway": " (sce:YDR329C); (R-SCE-1369062); (R-SCE-9603798)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10637226;14562106;16087670;16100114;18407956;1894692;19684113;19948495;24374639;32541053;32597660;33481703;33491328;40628847;9169867;9418908", "class_list": "", "function": "Multifunctional peroxisomal transmembrane protein involved in the insertion of peroxisomal membrane proteins, in pexophagy, and in the formation of membrane contact sites (PubMed:10637226, PubMed:16087670, PubMed:16100114, PubMed:1894692, PubMed:19948495, PubMed:40628847). Functions as an anchor for the peroxisome retention factor INP1 at the peroxisomal membrane, and this function is independent of its role in peroxisome biogenesis (PubMed:19948495). Involved in the formation of peroxisome-peroxisome and peroxisome-lipid droplet contact sites (PubMed:40628847). Acts as a regulator of MSP1 by inhibiting the ability of MSP1 to unfold target proteins (PubMed:32541053)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSW1", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0032581 ER-dependent peroxisome organization;GO:0045046 protein import into peroxisome membrane;GO:0045033 peroxisome inheritance", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P28795-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28817-1", "uniprot_id": [ { "id": "HIBCH_YEAST", "url": "https://www.uniprot.org/uniprot/P28817", "type": "external" } ], "mass": 56288.0, "length": 500, "protein_name": "Small ribosomal subunit protein mS47", "gene_name": "EHD3", "organism": "Yeast", "refseq_name": "mitochondrial 37S ribosomal protein mS47 EHD3", "refseq_ac": [ { "id": "NP_010321", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010321", "type": "external" } ], "gene_names_uniprotkb": "EHD3; MRP5; YD9673.08C", "gene_names_refseq": "EHD3; mS47", "protein_names_uniprotkb": "Small ribosomal subunit protein mS47; 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; 3-hydroxyisobutyryl-coenzyme A hydrolase; 3.1.2.4; HIB-CoA hydrolase; HIBYL-CoA-H", "protein_names_refseq": "mitochondrial 37S ribosomal protein mS47 EHD3", "tax_id": 559292, "disease": "3-hydroxyisobutryl-CoA hydrolase deficiency (Disease Ontology:DOID:0060949); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (sce:YDR036C); (R-SCE-70895)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11378903;12697341;14562095;14562106;14566057;14576278;17322287;17761666;24374639;25609543;28154081;2903861;33229814;9169867", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:14566057, PubMed:25609543, PubMed:28154081). mS47 has enzymatic activity in vitro, and is able to catalyze the specific hydrolysis of 3-hydroxyisobutyryl-CoA (HIBYL-CoA). However, because the turnover rate of mS47/EHD3 is only a fraction of that of the homologous mammalian enzyme, the physiological function of this activity remains unclear (PubMed:12697341). Has an indirect role in endocytic membrane trafficking (PubMed:11378903)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VS24;Q66RH2", "ec_number_list": [ { "id": "3.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.4", "type": "external" } ], "go_molecular_function": "GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006574 L-valine catabolic process;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P28817-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28834-1", "uniprot_id": [ { "id": "IDH1_YEAST", "url": "https://www.uniprot.org/uniprot/P28834", "type": "external" } ], "mass": 39324.0, "length": 360, "protein_name": "Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial", "gene_name": "IDH1", "organism": "Yeast", "refseq_name": "isocitrate dehydrogenase (NAD(+)) IDH1", "refseq_ac": [ { "id": "NP_014361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014361", "type": "external" } ], "gene_names_uniprotkb": "IDH1; N2690", "gene_names_refseq": "IDH1", "protein_names_uniprotkb": "Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial; 1.1.1.41; Isocitric dehydrogenase; NAD(+)-specific ICDH", "protein_names_refseq": "isocitrate dehydrogenase (NAD(+)) IDH1", "tax_id": 559292, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); retinitis pigmentosa 46 (Disease Ontology:DOID:0110409)", "pathway": " (sce:YNL037C); (R-SCE-71403)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14562106;1644826;2198251;24374639;32597660;33229814;33481703;33491328;7505425;9169873", "class_list": "", "function": "Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6W1E2", "ec_number_list": [ { "id": "1.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.2.3", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "7.1.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.8", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003723 RNA binding;GO:0051287 NAD binding;GO:0004449 isocitrate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006102 isocitrate metabolic process;GO:0006537 glutamate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P28834-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29029-1", "uniprot_id": [ { "id": "CHIT_YEAST", "url": "https://www.uniprot.org/uniprot/P29029", "type": "external" } ], "mass": 59015.0, "length": 562, "protein_name": "Endochitinase", "gene_name": "CTS1", "organism": "Yeast", "refseq_name": "chitinase", "refseq_ac": [ { "id": "NP_013388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013388", "type": "external" } ], "gene_names_uniprotkb": "CTS1; L8003.13; SCW2", "gene_names_refseq": "CTS1; SCW2", "protein_names_uniprotkb": "Endochitinase; 3.2.1.14; Soluble cell wall protein 2", "protein_names_refseq": "chitinase", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR286C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;17322287;1918080;24374639;9169871;9748433", "class_list": "glycogene;glycosylhydrolase", "function": "Chitinase is required for cell separation during growth of S.cerevisiae., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VYT1;P29028", "ec_number_list": [], "go_molecular_function": "GO:0004568 chitinase activity;GO:0008843 endochitinase activity;GO:0008061 chitin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0000324 fungal-type vacuole;GO:0005935 cellular bud neck", "go_biological_process": "GO:0000920 septum digestion after cytokinesis;GO:0000272 polysaccharide catabolic process;GO:0006032 chitin catabolic process;GO:0071555 cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P29029-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29340-1", "uniprot_id": [ { "id": "PEX4_YEAST", "url": "https://www.uniprot.org/uniprot/P29340", "type": "external" } ], "mass": 21118.0, "length": 183, "protein_name": "Ubiquitin-conjugating enzyme E2 PEX4", "gene_name": "PEX4", "organism": "Yeast", "refseq_name": "E2 ubiquitin-protein ligase peroxin 4", "refseq_ac": [ { "id": "NP_011649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011649", "type": "external" } ], "gene_names_uniprotkb": "PEX4; PAS2; UBC10", "gene_names_refseq": "PAS2; PEX4; UBC10", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 PEX4; 2.3.2.23; E2 ubiquitin-conjugating enzyme PEX4; Peroxin-4; Ubiquitin carrier protein; Ubiquitin-protein ligase", "protein_names_refseq": "E2 ubiquitin-protein ligase peroxin 4", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR133W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1326082;17322287;17452527;17550898;18644345;22085930;23896733;24374639;9169869", "class_list": "", "function": "E2 ubiquitin-conjugating enzyme involved in the ubiquitination of proteins associated with the peroxisomal membrane (PubMed:17452527, PubMed:17550898, PubMed:18644345, PubMed:22085930). Together with the peroxisomal retrotranslocation channel, involved in the monoubiquitination of the peroxisomal targeting signal receptor PEX5, targeting it for recycling to the cytosol (PubMed:17452527, PubMed:17550898, PubMed:18644345). May also be involved in the ubiquitination of PEX5 coreceptors (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUR5", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005777 peroxisome", "go_biological_process": "GO:0007031 peroxisome organization;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0051865 protein autoubiquitination;GO:0006513 protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P29340-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29453-1", "uniprot_id": [ { "id": "RL8B_YEAST", "url": "https://www.uniprot.org/uniprot/P29453", "type": "external" } ], "mass": 28112.0, "length": 256, "protein_name": "Large ribosomal subunit protein eL8B", "gene_name": "RPL8B", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL8 RPL8B", "refseq_ac": [ { "id": "NP_013055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013055", "type": "external" } ], "gene_names_uniprotkb": "RPL8B; KRB1; RPL4B", "gene_names_refseq": "KRB1; RPL8B; SCL41", "protein_names_uniprotkb": "Large ribosomal subunit protein eL8B; 60S ribosomal protein L8-B; L4-1; L4; RP6; YL5", "protein_names_refseq": "60S ribosomal protein eL8 RPL8B", "tax_id": 559292, "disease": "", "pathway": " (sce:YLL045C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 15, "publication_id_list": "14562095;14562106;1544921;2046660;22096102;23749301;24374639;24524803;32597660;33481703;33491328;8139928;8286414;9169871;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXW2", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P29453-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29461-1", "uniprot_id": [ { "id": "PTP2_YEAST", "url": "https://www.uniprot.org/uniprot/P29461", "type": "external" } ], "mass": 85868.0, "length": 750, "protein_name": "Tyrosine-protein phosphatase 2", "gene_name": "PTP2", "organism": "Yeast", "refseq_name": "tyrosine protein phosphatase PTP2", "refseq_ac": [ { "id": "NP_014851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014851", "type": "external" } ], "gene_names_uniprotkb": "PTP2", "gene_names_refseq": "PTP2", "protein_names_uniprotkb": "Tyrosine-protein phosphatase 2; 3.1.3.48; PTPase 2; Protein-tyrosine phosphatase 2", "protein_names_refseq": "tyrosine protein phosphatase PTP2", "tax_id": 559292, "disease": "azoospermia (Disease Ontology:DOID:14227)", "pathway": " (sce:YOR208W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "1452018;14562095;14562106;1549598;1577774;17330950;17563356;18407956;19779198;19795423;19823750;20489023;23749301;24374639;25492886;32597660;33481703;33491328;9032256;9169874;9211927", "class_list": "", "function": "Major phosphatase responsible with PTP3 for tyrosine dephosphorylation of MAP kinase HOG1 to inactivate its activity. May also be involved in the regulation of MAP kinase FUS3. May be implicated in the ubiquitin-mediated protein degradation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2R4", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0071474 cellular hyperosmotic response;GO:0051457 maintenance of protein location in nucleus;GO:0043937 regulation of sporulation;GO:0071507 pheromone response MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P29461-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29465-1", "uniprot_id": [ { "id": "CHS3_YEAST", "url": "https://www.uniprot.org/uniprot/P29465", "type": "external" } ], "mass": 131601.0, "length": 1165, "protein_name": "Chitin synthase 3", "gene_name": "CHS3", "organism": "Yeast", "refseq_name": "chitin synthase CHS3", "refseq_ac": [ { "id": "NP_009579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009579", "type": "external" } ], "gene_names_uniprotkb": "CHS3; CAL1; CSD2; DIT101; KIT2; YBR0305", "gene_names_refseq": "CAL1; CHS3; CSD2; DIT101; KTI2", "protein_names_uniprotkb": "Chitin synthase 3; 2.4.1.16; Chitin-UDP acetyl-glucosaminyl transferase 3; Class-IV chitin synthase 3", "protein_names_refseq": "chitin synthase CHS3", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR023C)", "pathway_count": 1, "publication_count": 32, "publication_id_list": "12872131;12928491;1293886;14562106;1532231;16818716;16847258;17330950;17519287;17563356;18407956;19779198;19795423;19823750;2050737;2050738;20702584;22218487;23749301;24374639;24909858;29763674;32597660;33481703;33491328;7813418;8091864;8909536;8970154;9234668;9314530;9760183", "class_list": "glycogene;glycosyltransferase", "function": "Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer (Probable) (PubMed:9760183). Appears to be responsible for synthesis of the majority of the chitin found in the cell wall periphery (PubMed:2050738). It is involved in the synthesis of the chitin ring that forms in the cell wall just before bud emergence (PubMed:2050738). This ring remains at the base of the bud as the bud grows and ultimately forms part of the bud scar marking the division site on the mother cell (PubMed:2050738). Also catalyzes the synthesis of chitin laid down during mating and spore cell-wall synthesis (PubMed:1293886, PubMed:2050737, PubMed:2050738)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ25", "ec_number_list": [ { "id": "2.4.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.16", "type": "external" } ], "go_molecular_function": "GO:0004100 chitin synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0006031 chitin biosynthetic process;GO:0030476 ascospore wall assembly;GO:0097271 protein localization to bud neck", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P29465-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0000000010001.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29468-1", "uniprot_id": [ { "id": "PAP_YEAST", "url": "https://www.uniprot.org/uniprot/P29468", "type": "external" } ], "mass": 64552.0, "length": 568, "protein_name": "Poly(A) polymerase", "gene_name": "PAP1", "organism": "Yeast", "refseq_name": "polynucleotide adenylyltransferase PAP1", "refseq_ac": [ { "id": "NP_012927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012927", "type": "external" } ], "gene_names_uniprotkb": "PAP1", "gene_names_refseq": "PAP1", "protein_names_uniprotkb": "Poly(A) polymerase; 2.7.7.19; PAP; Polynucleotide adenylyltransferase", "protein_names_refseq": "polynucleotide adenylyltransferase PAP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR002W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10611239;10958780;12819204;1441752;14562095;14562106;17223131;17850751;1840648;18407956;18537269;19779198;23749301;24374639;32597660;33491328;8196765;9236779", "class_list": "", "function": "Polymerase component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXT8", "ec_number_list": [ { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0031124 mRNA 3'-end processing;GO:0031126 sno(s)RNA 3'-end processing;GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P29468-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29478-1", "uniprot_id": [ { "id": "SEC65_YEAST", "url": "https://www.uniprot.org/uniprot/P29478", "type": "external" } ], "mass": 31170.0, "length": 273, "protein_name": "Signal recognition particle subunit SEC65", "gene_name": "SEC65", "organism": "Yeast", "refseq_name": "RNA-binding signal recognition particle subunit SEC65", "refseq_ac": [ { "id": "NP_013602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013602", "type": "external" } ], "gene_names_uniprotkb": "SEC65; YM8339.14C", "gene_names_refseq": "SEC65", "protein_names_uniprotkb": "Signal recognition particle subunit SEC65", "protein_names_refseq": "RNA-binding signal recognition particle subunit SEC65", "tax_id": 559292, "disease": "", "pathway": " (sce:YML105C); (R-SCE-1799339)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "1313947;1313948;17322287;18407956;23749301;24374639;33491328;7925282;9169872", "class_list": "", "function": "Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SEC65 is required for SRP integrity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0H9", "ec_number_list": [], "go_molecular_function": "GO:0008312 7S RNA binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting", "go_biological_process": "GO:0006614 SRP-dependent cotranslational protein targeting to membrane;GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P29478-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29509-1", "uniprot_id": [ { "id": "TRXB1_YEAST", "url": "https://www.uniprot.org/uniprot/P29509", "type": "external" } ], "mass": 34238.0, "length": 319, "protein_name": "Thioredoxin reductase 1", "gene_name": "TRR1", "organism": "Yeast", "refseq_name": "thioredoxin-disulfide reductase TRR1", "refseq_ac": [ { "id": "NP_010640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010640", "type": "external" } ], "gene_names_uniprotkb": "TRR1; D9476.5", "gene_names_refseq": "TRR1", "protein_names_uniprotkb": "Thioredoxin reductase 1; 1.8.1.9; TPx; TR; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; TrxR", "protein_names_refseq": "thioredoxin-disulfide reductase TRR1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR353W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562106;17322287;18407956;18930846;20235561;22984289;23749301;2428012;24374639;30516470;32597660;33481703;33491328;7961686;9169867", "class_list": "", "function": "Central component in the thioredoxin system. Reduces thioredoxins 1 and 2., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSY3", "ec_number_list": [ { "id": "1.8.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.9", "type": "external" } ], "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity;GO:0008198 ferrous iron binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0045454 cell redox homeostasis;GO:0019430 removal of superoxide radicals", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P29509-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29547-1", "uniprot_id": [ { "id": "EF1G1_YEAST", "url": "https://www.uniprot.org/uniprot/P29547", "type": "external" } ], "mass": 47088.0, "length": 415, "protein_name": "Elongation factor 1-gamma 1", "gene_name": "CAM1", "organism": "Yeast", "refseq_name": "translation elongation factor EF1B gamma", "refseq_ac": [ { "id": "NP_015277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015277", "type": "external" } ], "gene_names_uniprotkb": "CAM1; TEF3", "gene_names_refseq": "CAM1; TEF3", "protein_names_uniprotkb": "Elongation factor 1-gamma 1; CPBP; Calcium and membrane-binding protein 1; Calcium phospholipid-binding protein; EF-1-gamma 1; Eukaryotic elongation factor 1Bgamma 1; Translation elongation factor 1B gamma 1; eEF1Bgamma 1", "protein_names_refseq": "translation elongation factor EF1B gamma", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL048W); (R-SCE-156842)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "12824466;12972429;14562095;14562106;18407956;1882548;21126336;22814378;24374639;33481703;33491328;8247005;8465602;9169875", "class_list": "", "function": "Subunit of the eukaryotic elongation factor 1 complex (eEF1). Probably plays a role in anchoring the complex to other cellular components. May be involved in transcriptional regulation of MXR1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3W6;Q9URC6", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0005543 phospholipid binding;GO:0005509 calcium ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005840 ribosome;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006449 regulation of translational termination;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P29547-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29704-1", "uniprot_id": [ { "id": "ERG9_YEAST", "url": "https://www.uniprot.org/uniprot/P29704", "type": "external" } ], "mass": 51720.0, "length": 444, "protein_name": "Squalene synthase ERG9", "gene_name": "ERG9", "organism": "Yeast", "refseq_name": "bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase", "refseq_ac": [ { "id": "NP_012060", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012060", "type": "external" } ], "gene_names_uniprotkb": "ERG9", "gene_names_refseq": "ERG9", "protein_names_uniprotkb": "Squalene synthase ERG9; 2.5.1.21; Ergosterol biosynthetic protein 9; FPP:FPP farnesyltransferase ERG9; Farnesyl-diphosphate farnesyltransferase ERG9; SQS; SS", "protein_names_refseq": "bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase", "tax_id": 559292, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); cataract (Disease Ontology:DOID:83)", "pathway": " (sce:YHR190W); (R-SCE-9969896)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10209263;14562095;14562106;1807826;2068081;24374639;32679672;33481703;8091229;8323279;8663358;9742963", "class_list": "", "function": "Squalene synthase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:1807826, PubMed:2068081, PubMed:8323279, PubMed:9742963). ERG9 produces squalene from 2 farnesyl pyrophosphate moieties (PubMed:1807826, PubMed:8323279). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25. Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (PubMed:32679672)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLD8", "ec_number_list": [ { "id": "2.5.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.21", "type": "external" } ], "go_molecular_function": "GO:0051996 squalene synthase [NAD(P)H] activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006696 ergosterol biosynthetic process;GO:0008299 isoprenoid biosynthetic process;GO:0045338 farnesyl diphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P29704-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29952-1", "uniprot_id": [ { "id": "MPI_YEAST", "url": "https://www.uniprot.org/uniprot/P29952", "type": "external" } ], "mass": 48189.0, "length": 429, "protein_name": "Mannose-6-phosphate isomerase", "gene_name": "PMI40", "organism": "Yeast", "refseq_name": "mannose-6-phosphate isomerase PMI40", "refseq_ac": [ { "id": "NP_010918", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010918", "type": "external" } ], "gene_names_uniprotkb": "PMI40", "gene_names_refseq": "PMI40", "protein_names_uniprotkb": "Mannose-6-phosphate isomerase; 5.3.1.8; PMI; Phosphohexomutase; Phosphomannose isomerase", "protein_names_refseq": "mannose-6-phosphate isomerase PMI40", "tax_id": 559292, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Ib (Disease Ontology:DOID:0080554); carbohydrate metabolic disorder (Disease Ontology:DOID:2978)", "pathway": " (sce:YER003C); (R-SCE-446205)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "1377774;14562106;18407956;19779198;22218487;24374639;33481703;33491328;8448139;9169868", "class_list": "", "function": "Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLP9", "ec_number_list": [ { "id": "5.3.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.8", "type": "external" } ], "go_molecular_function": "GO:0004476 mannose-6-phosphate isomerase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000032 cell wall mannoprotein biosynthetic process;GO:0005975 carbohydrate metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0009298 GDP-mannose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P29952-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30605-1", "uniprot_id": [ { "id": "ITR1_YEAST", "url": "https://www.uniprot.org/uniprot/P30605", "type": "external" } ], "mass": 63570.0, "length": 584, "protein_name": "Myo-inositol transporter 1", "gene_name": "ITR1", "organism": "Yeast", "refseq_name": "myo-inositol transporter ITR1", "refseq_ac": [ { "id": "NP_010785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010785", "type": "external" } ], "gene_names_uniprotkb": "ITR1; D9719.3", "gene_names_refseq": "ITR1", "protein_names_uniprotkb": "Myo-inositol transporter 1", "protein_names_refseq": "myo-inositol transporter ITR1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR497C); (R-SCE-429593)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "12872131;14557538;15665377;16233524;16847258;17330950;19684113;19779198;19795423;19823750;2040626;20489023;20702584;21177495;22106047;22118465;22218487;23749301;24374639;32597660;33481703;33491328;34965436;9169867", "class_list": "", "function": "Major transporter for myo-inositol., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VTB9", "ec_number_list": [], "go_molecular_function": "GO:0005366 myo-inositol:proton symporter activity;GO:0005365 myo-inositol transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0071944 cell periphery;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015798 myo-inositol transport;GO:1904679 myo-inositol import across plasma membrane;GO:0007124 pseudohyphal growth", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P30605-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30619-1", "uniprot_id": [ { "id": "SEC1_YEAST", "url": "https://www.uniprot.org/uniprot/P30619", "type": "external" } ], "mass": 83480.0, "length": 724, "protein_name": "Protein transport protein SEC1", "gene_name": "SEC1", "organism": "Yeast", "refseq_name": "Sec1p", "refseq_ac": [ { "id": "NP_010448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010448", "type": "external" } ], "gene_names_uniprotkb": "SEC1; YD8358.18C", "gene_names_refseq": "SEC1", "protein_names_uniprotkb": "Protein transport protein SEC1", "protein_names_refseq": "Sec1p", "tax_id": 559292, "disease": "West syndrome (Disease Ontology:DOID:0050562); early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); developmental and epileptic encephalopathy 4 (Disease Ontology:DOID:0080436); familial hemophagocytic lymphohistiocytosis 5 (Disease Ontology:DOID:0110925); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (sce:YDR164C); (R-SCE-114516); (R-SCE-114608)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11875433;14562106;1767592;24374639;32597660;33481703;33491328;9169867", "class_list": "", "function": "Involved in docking and fusion of exocytic vesicles., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSE4", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0005934 cellular bud tip;GO:0005935 cellular bud neck", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0031340 positive regulation of vesicle fusion;GO:0006887 exocytosis;GO:0006904 vesicle docking involved in exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P30619-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30620-1", "uniprot_id": [ { "id": "PSO2_YEAST", "url": "https://www.uniprot.org/uniprot/P30620", "type": "external" } ], "mass": 76399.0, "length": 661, "protein_name": "DNA cross-link repair protein PSO2/SNM1", "gene_name": "PSO2", "organism": "Yeast", "refseq_name": "DNA cross-link repair protein PSO2", "refseq_ac": [ { "id": "NP_013857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013857", "type": "external" } ], "gene_names_uniprotkb": "PSO2; SNM1; YM9375.06C", "gene_names_refseq": "PSO2; SNM1", "protein_names_uniprotkb": "DNA cross-link repair protein PSO2/SNM1; 3.1.-.-", "protein_names_refseq": "DNA cross-link repair protein PSO2", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR137C)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10980408;11738934;12177301;12509272;14562106;14729978;15590324;15743825;1736091;18407956;19779198;23749301;24374639;32597660;33481703;33491328;37649278;7526204;8628215;9169872", "class_list": "", "function": "Required for DNA interstrand cross-link repair. This requires cleavage of cross-linked DNA to generate DNA double strand breaks (DSBs). This protein has 5' exonuclease activity on single-stranded and double-stranded DNA, which appears to be necessary for the processing of DNA double strand breaks prior to ligation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZW0;Q07072", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0035312 5'-3' DNA exonuclease activity;GO:0008409 5'-3' exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006281 DNA repair;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0036297 interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P30620-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30624-1", "uniprot_id": [ { "id": "LCF1_YEAST", "url": "https://www.uniprot.org/uniprot/P30624", "type": "external" } ], "mass": 77866.0, "length": 700, "protein_name": "Long-chain-fatty-acid--CoA ligase 1", "gene_name": "FAA1", "organism": "Yeast", "refseq_name": "long-chain fatty acid-CoA ligase FAA1", "refseq_ac": [ { "id": "NP_014962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014962", "type": "external" } ], "gene_names_uniprotkb": "FAA1; O6136", "gene_names_refseq": "FAA1", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase 1; 6.2.1.3; ACS; FACS; Fatty acid activator 1; Fatty acyl-CoA synthetase; Long-chain acyl-CoA synthetase 1", "protein_names_refseq": "long-chain fatty acid-CoA ligase FAA1", "tax_id": 559292, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); non-syndromic X-linked intellectual disability 63 (Disease Ontology:DOID:0112050); prostate cancer (Disease Ontology:DOID:10283); intellectual disability (Disease Ontology:DOID:1059); lung cancer (Disease Ontology:DOID:1324); Sjogren-Larsson syndrome (Disease Ontology:DOID:14501); breast cancer (Disease Ontology:DOID:1612); asthma (Disease Ontology:DOID:2841)", "pathway": " (sce:YOR317W); (R-SCE-434313); (R-SCE-75876)", "pathway_count": 3, "publication_count": 22, "publication_id_list": "10515935;11477098;12601005;14562106;1572893;18407956;19779198;21126336;21820081;22106047;22633490;22814378;23749301;24269233;24374639;24868093;27136724;32597660;33491328;8206942;8896266;9169874", "class_list": "", "function": "Activates long-chain fatty acids (LCFA) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. Also facilitates the transport of LCFAs into the cell, either by active transport or by decreasing the intracellular LCFA concentration (PubMed:11477098, PubMed:12601005, PubMed:27136724, PubMed:8206942). It may supplement intracellular myristoyl-CoA pools from exogenous myristate. Preferentially acts on C12:0-C16:0 fatty acids with myristic and pentadecanic acid (C15:0) having the highest activities (PubMed:8206942). Also involved in long-chain base (LCB) uptake of sphingolipids. In contrast ot LCFA uptake, LCB uptake does not require ATP, suggesting that the enzyme is directly involved in active LCB uptake (PubMed:27136724). Involved in the sphingolipid-to-glycerolipid metabolic pathway, converting the sphingolipid metabolite hexadecenoic acid to hexadecenoyl-CoA, which is then further converted to glycerolipids (PubMed:22633490)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W316", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0031956 medium-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005886 plasma membrane", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0044539 long-chain fatty acid import into cell;GO:0035336 long-chain fatty-acyl-CoA metabolic process;GO:1905329 sphingoid long-chain base transport", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P30624-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30657-1", "uniprot_id": [ { "id": "PSB7_YEAST", "url": "https://www.uniprot.org/uniprot/P30657", "type": "external" } ], "mass": 29443.0, "length": 266, "protein_name": "Proteasome subunit beta type-7", "gene_name": "PRE4", "organism": "Yeast", "refseq_name": "proteasome core particle subunit beta 7", "refseq_ac": [ { "id": "NP_116708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116708", "type": "external" } ], "gene_names_uniprotkb": "PRE4", "gene_names_refseq": "PRE4", "protein_names_uniprotkb": "Proteasome subunit beta type-7; Macropain subunit PRE4; Multicatalytic endopeptidase complex subunit PRE4; Proteasome component PRE4; Proteinase YSCE subunit PRE4", "protein_names_refseq": "proteasome core particle subunit beta 7", "tax_id": 559292, "disease": "proteasome-associated autoinflammatory syndrome 3 (Disease Ontology:DOID:0060916)", "pathway": " (sce:YFR050C); (R-SCE-1236974); (R-SCE-1236978); (R-SCE-5668541); (R-SCE-5689880); (R-SCE-9907900); (R-SCE-9912633)", "pathway_count": 7, "publication_count": 17, "publication_id_list": "11062564;11081519;11500370;14562095;14562106;16531229;16608349;16793518;17322287;20227375;22927375;24374639;33491328;7670463;8381431;8686379;9087403", "class_list": "", "function": "Non-catalytic component of the proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. PRE3 and PRE4 are necessary for the peptidyl-glutamyl-peptide-hydrolyzing activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTT3;E9P8Z8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0043248 proteasome assembly;GO:0010499 proteasomal ubiquitin-independent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P30657-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30665-1", "uniprot_id": [ { "id": "MCM4_YEAST", "url": "https://www.uniprot.org/uniprot/P30665", "type": "external" } ], "mass": 105003.0, "length": 933, "protein_name": "DNA replication licensing factor MCM4", "gene_name": "MCM4", "organism": "Yeast", "refseq_name": "MCM DNA helicase complex subunit MCM4", "refseq_ac": [ { "id": "NP_015344", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015344", "type": "external" } ], "gene_names_uniprotkb": "MCM4; CDC54; HCD21; YP9531.13", "gene_names_refseq": "CDC54; HCD21; MCM4", "protein_names_uniprotkb": "DNA replication licensing factor MCM4; 3.6.4.12; Cell division control protein 54", "protein_names_refseq": "MCM DNA helicase complex subunit MCM4", "tax_id": 559292, "disease": "immunodeficiency 54 (Disease Ontology:DOID:0111967); endometrial cancer (Disease Ontology:DOID:1380)", "pathway": " (sce:YPR019W); (R-SCE-176187); (R-SCE-68867); (R-SCE-68962); (R-SCE-69052)", "pathway_count": 5, "publication_count": 21, "publication_id_list": "1454522;14562106;15665377;18321994;18407956;18657510;19684113;19779198;19896182;19910535;21070963;21126336;21177495;23749301;24374639;32597660;33229814;33481703;33491328;34963704;9169875", "class_list": "", "function": "Acts as a component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Once loaded onto DNA, double hexamers can slide on dsDNA in the absence of ATPase activity. Required for S phase execution., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 16, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 16, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 16, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 34, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "D6W429", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0004386 helicase activity", "go_cellular_component": "GO:0005656 nuclear pre-replicative complex;GO:0031261 DNA replication preinitiation complex;GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication;GO:0006271 DNA strand elongation involved in DNA replication;GO:0006260 DNA replication;GO:0006270 DNA replication initiation;GO:1902975 mitotic DNA replication initiation", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P30665-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30771-1", "uniprot_id": [ { "id": "RENT1_YEAST", "url": "https://www.uniprot.org/uniprot/P30771", "type": "external" } ], "mass": 109430.0, "length": 971, "protein_name": "ATP-dependent helicase NAM7", "gene_name": "NAM7", "organism": "Yeast", "refseq_name": "ATP-dependent RNA helicase NAM7", "refseq_ac": [ { "id": "NP_013797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013797", "type": "external" } ], "gene_names_uniprotkb": "NAM7; IFS2; MOF4; UPF1; YM9582.05C", "gene_names_refseq": "IFS2; MOF4; NAM7; SUP113; SUT2; UPF1", "protein_names_uniprotkb": "ATP-dependent helicase NAM7; 5.6.2.3; 5.6.2.5; Double-stranded nucleic acid 5'-3' helicase Upf1; Nonsense-mediated mRNA decay protein 1; Nuclear accommodation of mitochondria 7 protein; Up-frameshift suppressor 1", "protein_names_refseq": "ATP-dependent RNA helicase NAM7", "tax_id": 559292, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (sce:YMR080C); (R-SCE-975956); (R-SCE-975957)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "1314899;14562106;1569946;17330950;18407956;19779198;21419344;22218487;23749301;24198248;24374639;30218034;33481703;33491328;7489520;7545033;8816461;8896465;9169872", "class_list": "", "function": "RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and which modulates the expression level of normal mRNAs (PubMed:30218034, PubMed:8896465). Has ATP-dependent 5'-3' RNA helicase activity on substrate with a 5'-extension; is not active on RNA with a 3'-extension (PubMed:7489520, PubMed:8816461). Has ATP-dependent 5'-3' DNA helicase activity; is not active on DNA with a 3'-extension (PubMed:30218034, PubMed:7489520). The ATPase activity is most stimulated by poly(U) and poly(dT), hydrolyzes ATP and dATP (PubMed:7489520). In the absence of ATP binds single-stranded (ss)DNA and RNA; addition of ATP (but not a non-hydrolyzable analog) destabilizes the complex (PubMed:7489520). Probably has 5'-3' RNA:DNA helicase activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZQ4", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006449 regulation of translational termination;GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay;GO:0006310 DNA recombination;GO:0016567 protein ubiquitination;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P30771-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30775-1", "uniprot_id": [ { "id": "RF1M_YEAST", "url": "https://www.uniprot.org/uniprot/P30775", "type": "external" } ], "mass": 46770.0, "length": 413, "protein_name": "Peptide chain release factor 1, mitochondrial", "gene_name": "MRF1", "organism": "Yeast", "refseq_name": "Mrf1p", "refseq_ac": [ { "id": "NP_011372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011372", "type": "external" } ], "gene_names_uniprotkb": "MRF1", "gene_names_refseq": "MRF1", "protein_names_uniprotkb": "Peptide chain release factor 1, mitochondrial; MRF-1; MtRF-1", "protein_names_refseq": "Mrf1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL143C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;1475194;16321977;24374639;9046099;9169869", "class_list": "", "function": "Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU06", "ec_number_list": [], "go_molecular_function": "GO:0003747 translation release factor activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006415 translational termination;GO:0070126 mitochondrial translational termination;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P30775-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30902-1", "uniprot_id": [ { "id": "ATP7_YEAST", "url": "https://www.uniprot.org/uniprot/P30902", "type": "external" } ], "mass": 19810.0, "length": 174, "protein_name": "ATP synthase subunit d, mitochondrial", "gene_name": "ATP7", "organism": "Yeast", "refseq_name": "F1F0 ATP synthase subunit d", "refseq_ac": [ { "id": "NP_012909", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012909", "type": "external" } ], "gene_names_uniprotkb": "ATP7", "gene_names_refseq": "ATP7", "protein_names_uniprotkb": "ATP synthase subunit d, mitochondrial", "protein_names_refseq": "F1F0 ATP synthase subunit d", "tax_id": 559292, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (sce:YKL016C); (R-SCE-9837999)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14562106;17322287;1832157;24374639;33481703;33491328;8154185;8196765", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXS0", "ec_number_list": [], "go_molecular_function": "GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P30902-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30952-1", "uniprot_id": [ { "id": "MLS1_YEAST", "url": "https://www.uniprot.org/uniprot/P30952", "type": "external" } ], "mass": 62791.0, "length": 554, "protein_name": "Malate synthase 1", "gene_name": "MLS1", "organism": "Yeast", "refseq_name": "malate synthase MLS1", "refseq_ac": [ { "id": "NP_014282", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014282", "type": "external" } ], "gene_names_uniprotkb": "MLS1; N1921", "gene_names_refseq": "MLS1", "protein_names_uniprotkb": "Malate synthase 1; 2.3.3.9", "protein_names_refseq": "malate synthase MLS1", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL117W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11846793;1454530;16103919;18780730;24374639;27678487;33491328;9090055;9169873", "class_list": "", "function": "Malate synthase which takes part in the glyoxylate cycle (PubMed:1454530). MLS1 activity is essential for cells to grow on oleic acid as a sole carbon source (PubMed:11846793). Two steps of the glyoxylate cycle take place in the cytosol, the splitting of isocitrate into succinate and glyoxylate, and the dehydrogenation of malate to oxaloacetate (PubMed:1454530). However, the formation of malate from glyoxylate and acetyl-CoA undertaken MLS1, occurs in the peroxisomes when cells are grown on oleic acid (Probable). The source of acetyl-CoA being either peroxisomal when breaking down fatty acids, or cytosolic when extra-cellular two-carbon substrates are used, therefore, although not strictly essential, the peroxisomal localization of MLS1 appears to be advantageous for cells growing on oleic acid, in that acetyl-CoA production and utilization are thereby intimately compartmentalized together to increase efficiency (Probable)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0KZR8;B0KZS7;B0KZU5;B0KZY1;B0L026;D6W165;Q4KQ64;Q4KQ91;Q4KQC3;Q4KQC4;Q4KQC8", "ec_number_list": [ { "id": "2.3.3.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.9", "type": "external" } ], "go_molecular_function": "GO:0004474 malate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006097 glyoxylate cycle", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P30952-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31109-1", "uniprot_id": [ { "id": "SNC1_YEAST", "url": "https://www.uniprot.org/uniprot/P31109", "type": "external" } ], "mass": 13201.0, "length": 117, "protein_name": "Synaptobrevin homolog 1", "gene_name": "SNC1", "organism": "Yeast", "refseq_name": "SNAP receptor SNC1", "refseq_ac": [ { "id": "NP_009372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009372", "type": "external" } ], "gene_names_uniprotkb": "SNC1", "gene_names_refseq": "SNC1", "protein_names_uniprotkb": "Synaptobrevin homolog 1", "protein_names_refseq": "SNAP receptor SNC1", "tax_id": 559292, "disease": "spastic ataxia 1 (Disease Ontology:DOID:0050772); congenital myasthenic syndrome (Disease Ontology:DOID:3635)", "pathway": " (sce:YAL030W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12872131;1316605;15665377;15973437;19779198;21126336;22218487;23749301;24374639;33481703;33491328;7731988", "class_list": "", "function": "SNC1 and SNC2 are vesicle-targeting proteins essential for normal secretory traffic between the Golgi and the plasma membrane. They may also be involved in vesicle fusion., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPI8", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019905 syntaxin binding;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030658 transport vesicle membrane", "go_biological_process": "GO:0048210 Golgi vesicle fusion to target membrane;GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0042147 retrograde transport, endosome to Golgi;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P31109-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31111-1", "uniprot_id": [ { "id": "ZIP1_YEAST", "url": "https://www.uniprot.org/uniprot/P31111", "type": "external" } ], "mass": 100035.0, "length": 875, "protein_name": "Synaptonemal complex protein ZIP1", "gene_name": "ZIP1", "organism": "Yeast", "refseq_name": "Zip1p", "refseq_ac": [ { "id": "NP_010571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010571", "type": "external" } ], "gene_names_uniprotkb": "ZIP1; D9819.9", "gene_names_refseq": "ZIP1", "protein_names_uniprotkb": "Synaptonemal complex protein ZIP1", "protein_names_refseq": "Zip1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR285W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562106;18407956;20825495;20951350;23749301;24374639;26682552;32597660;33481703;33491328;33502312;7916652;9169867", "class_list": "", "function": "Required for meiotic chromosome synapsis and cell cycle progression. May act as a molecular zipper to bring homologous chromosomes in close apposition. ZIP1 may encode the transverse filaments of the synaptonemal complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSR5", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0032184 SUMO polymer binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005737 cytoplasm;GO:0000775 chromosome, centromeric region;GO:0032982 myosin filament;GO:0000795 synaptonemal complex", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0000724 double-strand break repair via homologous recombination;GO:0033235 positive regulation of protein sumoylation;GO:0007129 homologous chromosome pairing at meiosis;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P31111-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31115-1", "uniprot_id": [ { "id": "PUS3_YEAST", "url": "https://www.uniprot.org/uniprot/P31115", "type": "external" } ], "mass": 50889.0, "length": 442, "protein_name": "tRNA pseudouridine(38/39) synthase", "gene_name": "DEG1", "organism": "Yeast", "refseq_name": "pseudouridine synthase DEG1", "refseq_ac": [ { "id": "NP_116655", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116655", "type": "external" } ], "gene_names_uniprotkb": "DEG1; HRM3; PUS3", "gene_names_refseq": "DEG1; HRM3; PUS3", "protein_names_uniprotkb": "tRNA pseudouridine(38/39) synthase; 5.4.99.45; Depressed growth-rate protein DEG1; tRNA pseudouridine synthase 3; tRNA pseudouridylate synthase 3; tRNA-uridine isomerase 3", "protein_names_refseq": "pseudouridine synthase DEG1", "tax_id": 559292, "disease": "", "pathway": " (sce:YFL001W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562106;17322287;18407956;19779198;2036682;20702584;23749301;24374639;32597660;33229814;33481703;33491328;7670463;8789262;9430663", "class_list": "", "function": "Formation of pseudouridines at positions 38 and 39 in the anticodon stem and loop of transfer RNAs., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VTN0", "ec_number_list": [ { "id": "5.4.99.45", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.45", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0009982 pseudouridine synthase activity;GO:0160154 tRNA pseudouridine(38/39) synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0031119 tRNA pseudouridine synthesis;GO:1990481 mRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P31115-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31116-1", "uniprot_id": [ { "id": "DHOM_YEAST", "url": "https://www.uniprot.org/uniprot/P31116", "type": "external" } ], "mass": 38502.0, "length": 359, "protein_name": "Homoserine dehydrogenase", "gene_name": "HOM6", "organism": "Yeast", "refseq_name": "homoserine dehydrogenase", "refseq_ac": [ { "id": "NP_012673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012673", "type": "external" } ], "gene_names_uniprotkb": "HOM6; J2132", "gene_names_refseq": "HOM6; THR6", "protein_names_uniprotkb": "Homoserine dehydrogenase; 1.1.1.3; HDH; HSD", "protein_names_refseq": "homoserine dehydrogenase", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR139C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10700284;11341914;14562106;14583265;15210149;1633844;17330950;17563356;18407956;1897932;22106047;23749301;24374639;33481703;33491328;8500624;8641269", "class_list": "", "function": "Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VWV8", "ec_number_list": [ { "id": "1.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.3", "type": "external" } ], "go_molecular_function": "GO:0070403 NAD+ binding;GO:0050661 NADP binding;GO:0004412 homoserine dehydrogenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0009086 methionine biosynthetic process;GO:0009088 threonine biosynthetic process;GO:0009067 aspartate family amino acid biosynthetic process;GO:0009090 homoserine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P31116-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000010001001.011.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31373-1", "uniprot_id": [ { "id": "CYS3_YEAST", "url": "https://www.uniprot.org/uniprot/P31373", "type": "external" } ], "mass": 42542.0, "length": 394, "protein_name": "Cystathionine gamma-lyase", "gene_name": "CYS3", "organism": "Yeast", "refseq_name": "cystathionine gamma-lyase CYS3", "refseq_ac": [ { "id": "NP_009390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009390", "type": "external" } ], "gene_names_uniprotkb": "CYS3; CYI1; FUN35; STR1", "gene_names_refseq": "CYI1; CYS3; FUN35; STR1", "protein_names_uniprotkb": "Cystathionine gamma-lyase; 4.4.1.1; Gamma-cystathionase; Sulfur transfer protein 1; gamma-CTLase", "protein_names_refseq": "cystathionine gamma-lyase CYS3", "tax_id": 559292, "disease": "cystathioninuria (Disease Ontology:DOID:0090142); cataract (Disease Ontology:DOID:83); amino acid metabolic disorder (Disease Ontology:DOID:9252); homocystinuria (Disease Ontology:DOID:9263)", "pathway": " (sce:YAL012W); (R-SCE-1614558); (R-SCE-1614603)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "12715888;14562095;14562106;15665377;1577698;18407956;19779198;20702584;21126336;23749301;24374639;32597660;33481703;33491328;7731988;8335636;8458570;8511966;8511969", "class_list": "", "function": "Catalyzes the production of cysteine from cystathionine in the reverse transsulfuration pathway for the biosynthesis of sulfur-containing amino acids cysteine and methionine. In this pathway, homocysteine sulfur is converted to cysteine sulfur (Probable). Also has cystathionine beta-lyase and cystathionine gamma-synthase activities in vitro. Cystathionine beta-lyase may be physiological, while cystathionine gamma-synthase activity is not, as the required substrate O-succinyl-L-homoserine(OSH) does not occur naturally in S.cerevisiae (PubMed:8335636)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPK6", "ec_number_list": [ { "id": "4.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.1", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004123 cystathionine gamma-lyase activity;GO:0047804 cysteine-S-conjugate beta-lyase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1904828 positive regulation of hydrogen sulfide biosynthetic process;GO:0019346 transsulfuration;GO:0019343 cysteine biosynthetic process via cystathionine;GO:0019344 cysteine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P31373-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31374-1", "uniprot_id": [ { "id": "PSK1_YEAST", "url": "https://www.uniprot.org/uniprot/P31374", "type": "external" } ], "mass": 152332.0, "length": 1356, "protein_name": "Serine/threonine-protein kinase PSK1", "gene_name": "PSK1", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase PSK1", "refseq_ac": [ { "id": "NP_009385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009385", "type": "external" } ], "gene_names_uniprotkb": "PSK1; FUN31; YAL002", "gene_names_refseq": "FUN31; PSK1", "protein_names_uniprotkb": "Serine/threonine-protein kinase PSK1; 2.7.11.1; PAS kinase 1", "protein_names_refseq": "serine/threonine protein kinase PSK1", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL017W)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "11459942;12372297;14562095;14562106;1561836;15665377;17287358;17330950;17531808;17563356;18407956;19684113;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22218487;23749301;24374639;32597660;33229814;33481703;33491328;7731988;8322517;8458570", "class_list": "", "function": "Serine/threonine-protein kinase involved in the control of sugar metabolism and translation. Phosphorylates UGP1, which is required for normal glycogen and beta-(1,6)-glucan synthesis. This phosphorylation shifts glucose partitioning toward cell wall glucan synthesis at the expense of glycogen synthesis., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 69, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VPK1", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006417 regulation of translation;GO:0035556 intracellular signal transduction;GO:0045719 negative regulation of glycogen biosynthetic process;GO:0060917 regulation of (1->6)-beta-D-glucan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P31374-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31376-1", "uniprot_id": [ { "id": "SWC3_YEAST", "url": "https://www.uniprot.org/uniprot/P31376", "type": "external" } ], "mass": 72514.0, "length": 625, "protein_name": "SWR1-complex protein 3", "gene_name": "SWC3", "organism": "Yeast", "refseq_name": "Swc3p", "refseq_ac": [ { "id": "NP_009391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009391", "type": "external" } ], "gene_names_uniprotkb": "SWC3; FUN36; SWC1", "gene_names_refseq": "SWC1; SWC3", "protein_names_uniprotkb": "SWR1-complex protein 3", "protein_names_refseq": "Swc3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL011W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12748633;14562095;14562106;14645854;14690608;15045029;17563356;18407956;19779198;20702584;23749301;24374639;32597660;33481703;33491328;7731988;8458570", "class_list": "", "function": "Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VPK7", "ec_number_list": [], "go_molecular_function": "GO:0031492 nucleosomal DNA binding;GO:0140849 ATP-dependent H2AZ histone chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0000785 chromatin;GO:0000812 Swr1 complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0007029 endoplasmic reticulum organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P31376-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31377-1", "uniprot_id": [ { "id": "STX8_YEAST", "url": "https://www.uniprot.org/uniprot/P31377", "type": "external" } ], "mass": 29049.0, "length": 255, "protein_name": "Syntaxin-8", "gene_name": "SYN8", "organism": "Yeast", "refseq_name": "syntaxin", "refseq_ac": [ { "id": "NP_009388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009388", "type": "external" } ], "gene_names_uniprotkb": "SYN8; FUN34; UIP2", "gene_names_refseq": "SLT2; SYN8; UIP2", "protein_names_uniprotkb": "Syntaxin-8; SNARE protein related to mammalian syntaxin 8; ULP1-interacting protein 2", "protein_names_refseq": "syntaxin", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL014C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12453154;15973437;16751107;24374639;33491328;7731988;8144453;8458570", "class_list": "", "function": "t-SNARE which may play a role in determining the specificity of membrane fusion, protein transport and vesicle trafficking within the Golgi/endosomal and plasma membrane/endosomal systems., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPK4", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005829 cytosol;GO:0012505 endomembrane system;GO:0010008 endosome membrane", "go_biological_process": "GO:0048210 Golgi vesicle fusion to target membrane;GO:0006886 intracellular protein transport;GO:0006895 Golgi to endosome transport;GO:0006906 vesicle fusion;GO:0048278 vesicle docking", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P31377-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31378-1", "uniprot_id": [ { "id": "NTH1_YEAST", "url": "https://www.uniprot.org/uniprot/P31378", "type": "external" } ], "mass": 45577.0, "length": 399, "protein_name": "Endonuclease III homolog 1", "gene_name": "NTG1", "organism": "Yeast", "refseq_name": "bifunctional N-glycosylase/AP lyase NTG1", "refseq_ac": [ { "id": "NP_009387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009387", "type": "external" } ], "gene_names_uniprotkb": "NTG1; FUN33; OGG2; SCR1", "gene_names_refseq": "FUN33; NTG1; SCR1; ogg2", "protein_names_uniprotkb": "Endonuclease III homolog 1; 3.2.2.-; 4.2.99.18; Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 1; DNA glycosylase/AP lyase 1; Endonuclease III-like glycosylase 1; Redoxyendonuclease 1", "protein_names_refseq": "bifunctional N-glycosylase/AP lyase NTG1", "tax_id": 559292, "disease": "familial adenomatous polyposis 3 (Disease Ontology:DOID:0080411)", "pathway": " (sce:YAL015C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10207101;10471279;14500818;14697759;15923634;16730479;18983898;19029246;19074198;20194111;24374639;33491328;7731988;8144453;8458570;8805338;8855249;9020769;9545197;9558341;9826748", "class_list": "", "function": "Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines, but also purine-derived lesions, alkylation damage and cytosine photoproducts generated by UV irradiation as well as abasic sites. Also has 8-oxoguanine DNA glycosylase activity. The AP lyase can incise AP sites opposite all four bases. May also play a role in the regulation of mtDNA copy number by introducing a double-stranded break (DSB) at the mtDNA replication origin ori5, initiating the rolling-circle mtDNA replication., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPK3", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity;GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0090297 positive regulation of mitochondrial DNA replication;GO:0006281 DNA repair;GO:0006284 base-excision repair;GO:0034599 cellular response to oxidative stress;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P31378-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31380-1", "uniprot_id": [ { "id": "FUN30_YEAST", "url": "https://www.uniprot.org/uniprot/P31380", "type": "external" } ], "mass": 128507.0, "length": 1131, "protein_name": "Chromatin remodeling protein FUN30", "gene_name": "FUN30", "organism": "Yeast", "refseq_name": "DNA-dependent ATPase FUN30", "refseq_ac": [ { "id": "NP_009383", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009383", "type": "external" } ], "gene_names_uniprotkb": "FUN30; YAL001", "gene_names_refseq": "FUN30", "protein_names_uniprotkb": "Chromatin remodeling protein FUN30; 3.6.4.-; Chromatin remodeler FUN30", "protein_names_refseq": "DNA-dependent ATPase FUN30", "tax_id": 559292, "disease": "asphyxiating thoracic dystrophy (Disease Ontology:DOID:0050592); BASAN syndrome (Disease Ontology:DOID:0080725); adermatoglyphia (Disease Ontology:DOID:0111357)", "pathway": " (sce:YAL019W)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "14562106;1561836;15665377;17330950;17563356;18407956;19779198;19795423;19823750;19956593;20075079;20190278;20702584;21126336;21177495;22960743;22960744;23007155;23028372;23749301;24374639;28045388;30516470;32597660;33481703;33491328;34965436;7731988;8144453;8458570", "class_list": "", "function": "Protein that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:20075079) and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs, facilitating single-stranded DNA (ssDNA) production by the EXO1 and SGS1 machinery. Promotes gene silencing at heterochromatin by regulating the chromatin structure within or around silent loci. Also required for heterochromatin organization at centromeres. Has ATPase activity that is stimulated by DNA or chromatin, binds both DNA and chromatin (PubMed:20075079)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 39, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VPJ9", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0031509 subtelomeric heterochromatin formation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P31380-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31382-1", "uniprot_id": [ { "id": "PMT2_YEAST", "url": "https://www.uniprot.org/uniprot/P31382", "type": "external" } ], "mass": 86870.0, "length": 759, "protein_name": "Dolichyl-phosphate-mannose--protein mannosyltransferase 2", "gene_name": "PMT2", "organism": "Yeast", "refseq_name": "dolichyl-phosphate-mannose-protein mannosyltransferase PMT2", "refseq_ac": [ { "id": "NP_009379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009379", "type": "external" } ], "gene_names_uniprotkb": "PMT2; FUN25", "gene_names_refseq": "FUN25; PMT2", "protein_names_uniprotkb": "Dolichyl-phosphate-mannose--protein mannosyltransferase 2; 2.4.1.109", "protein_names_refseq": "dolichyl-phosphate-mannose-protein mannosyltransferase PMT2", "tax_id": 559292, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Walker-Warburg syndrome (Disease Ontology:DOID:0050560); autosomal recessive limb-girdle muscular dystrophy (Disease Ontology:DOID:0110274); autosomal recessive limb-girdle muscular dystrophy type 2N (Disease Ontology:DOID:0110298); congenital muscular dystrophy-dystroglycanopathy type A2 (Disease Ontology:DOID:0111240); muscular dystrophy-dystroglycanopathy (Disease Ontology:DOID:0112374); muscular dystrophy-dystroglycanopathy type B2 (Disease Ontology:DOID:0112380); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (sce:YAL023C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "12551906;14562106;15377669;16847258;17330950;18182384;18407956;19684113;19779198;21147851;21177495;22814378;23749301;24374639;32597660;33481703;33491328;7731988;7852348;8458570;8543034;8918452", "class_list": "glycogene;glycosyltransferase", "function": "Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT2 and more rarely with PMT5 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins. The PMT1-PMT2 complex participates in oxidative protein folding, ER-associated protein degradation (ERAD), as well as ER export., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VPJ5", "ec_number_list": [ { "id": "2.4.1.109", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.109", "type": "external" } ], "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0097582 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex;GO:0097584 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0036503 ERAD pathway;GO:0035269 protein O-linked glycosylation via mannose;GO:0032527 protein exit from endoplasmic reticulum;GO:1900101 regulation of endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P31382-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000010001.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31383-1", "uniprot_id": [ { "id": "2AAA_YEAST", "url": "https://www.uniprot.org/uniprot/P31383", "type": "external" } ], "mass": 70907.0, "length": 635, "protein_name": "Protein phosphatase PP2A regulatory subunit A", "gene_name": "TPD3", "organism": "Yeast", "refseq_name": "protein phosphatase 2A structural subunit TPD3", "refseq_ac": [ { "id": "NP_009386", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009386", "type": "external" } ], "gene_names_uniprotkb": "TPD3; FUN32", "gene_names_refseq": "FUN32; TPD3", "protein_names_uniprotkb": "Protein phosphatase PP2A regulatory subunit A; PR65", "protein_names_refseq": "protein phosphatase 2A structural subunit TPD3", "tax_id": 559292, "disease": "autosomal dominant intellectual developmental disorder 36 (Disease Ontology:DOID:0070066); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (sce:YAL016W); (R-SCE-198753); (R-SCE-202670); (R-SCE-389513); (R-SCE-6811558); (R-SCE-69273); (R-SCE-975957)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "1328868;14562106;19779198;24374639;33481703;7731988;8144453;8458570", "class_list": "", "function": "Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPK2", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex;GO:0005816 spindle pole body", "go_biological_process": "GO:0006417 regulation of translation;GO:0051754 meiotic sister chromatid cohesion, centromeric;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P31383-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31385-1", "uniprot_id": [ { "id": "DEP1_YEAST", "url": "https://www.uniprot.org/uniprot/P31385", "type": "external" } ], "mass": 46978.0, "length": 405, "protein_name": "Transcriptional regulatory protein DEP1", "gene_name": "DEP1", "organism": "Yeast", "refseq_name": "Rpd3L histone deacetylase complex subunit DEP1", "refseq_ac": [ { "id": "NP_009389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009389", "type": "external" } ], "gene_names_uniprotkb": "DEP1; FUN54", "gene_names_refseq": "DEP1; FUN54", "protein_names_uniprotkb": "Transcriptional regulatory protein DEP1", "protein_names_refseq": "Rpd3L histone deacetylase complex subunit DEP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL013W); (R-SCE-3214815)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "12844361;16286008;16314178;18407956;19779198;19795423;19823750;21126336;23749301;24374639;33481703;33491328;7731988;8056324;8144453;8458570", "class_list": "", "function": "Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPK5;Q86ZS5", "ec_number_list": [], "go_molecular_function": "GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0070822 Sin3-type complex;GO:0070210 Rpd3L-Expanded complex;GO:0033698 Rpd3L complex", "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P31385-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31539-1", "uniprot_id": [ { "id": "HS104_YEAST", "url": "https://www.uniprot.org/uniprot/P31539", "type": "external" } ], "mass": 102035.0, "length": 908, "protein_name": "Heat shock protein 104", "gene_name": "HSP104", "organism": "Yeast", "refseq_name": "chaperone ATPase HSP104", "refseq_ac": [ { "id": "NP_013074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013074", "type": "external" } ], "gene_names_uniprotkb": "HSP104; L0948", "gene_names_refseq": "HSP104", "protein_names_uniprotkb": "Heat shock protein 104; Protein aggregation-remodeling factor HSP104", "protein_names_refseq": "chaperone ATPase HSP104", "tax_id": 559292, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); 3-methylglutaconic aciduria type 7a (Disease Ontology:DOID:0081133); 3-methylglutaconic aciduria type 7b (Disease Ontology:DOID:0081134)", "pathway": " (sce:YLL026W)", "pathway_count": 1, "publication_count": 65, "publication_id_list": "10467108;10678178;11073991;11158570;11375656;11442834;11604493;11782421;11867765;11967066;11983167;12101251;12105276;14507919;14557538;14562095;14562106;14668331;14978213;15049822;15128736;15155912;15843375;15845535;1600951;16135516;16570324;16885031;17253904;17259993;17322287;17367387;17543332;17563356;17973656;18160044;18197703;18312264;18407956;18756251;1896074;19779198;19795423;19823750;2188365;22106047;22814378;23749301;24374639;30516470;32597660;33229814;33481703;33491328;7754373;7984243;8308017;8407824;8643570;9046100;9169871;9534180;9624144;9674429;9703962", "class_list": "", "function": "Required, in concert with Hsp40 (YDJ1) and Hsp70 (SSA1) and small Hsps (HSP26), for the dissociation, resolubilization and refolding of aggregates of damaged proteins after heat or other environmental stresses. Extracts proteins from aggregates by unfolding and threading them in an ATP-dependent process through the axial channel of the protein hexamer, after which they can be refolded by components of the Hsp70/Hsp40 chaperone system. Substrate binding is ATP-dependent, and release of bound polypeptide is triggered by ATP hydrolysis. Also responsible for the maintenance of prions by dissociating prion fibrils into smaller oligomers, thereby producing transmissible seeds that can infect daughter cells during mitosis and meiosis. Loss of HSP104 can cure yeast cells of the prions [PSI+], [URE3] and [PIN+]. Excess HSP104 can also specifically cure cells of [PSI+]., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 27, "reported_mutagensis": 43, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VXX8", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0034399 nuclear periphery;GO:0072380 TRC complex", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0043335 protein unfolding;GO:0034605 cellular response to heat;GO:0006457 protein folding;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 7.0, "record_id": "P31539-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31688-1", "uniprot_id": [ { "id": "TPS2_YEAST", "url": "https://www.uniprot.org/uniprot/P31688", "type": "external" } ], "mass": 102976.0, "length": 896, "protein_name": "Trehalose-phosphatase", "gene_name": "TPS2", "organism": "Yeast", "refseq_name": "trehalose-phosphatase TPS2", "refseq_ac": [ { "id": "NP_010359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010359", "type": "external" } ], "gene_names_uniprotkb": "TPS2; PFK3; YD8554.07", "gene_names_refseq": "HOG2; PFK3; TPS2", "protein_names_uniprotkb": "Trehalose-phosphatase; 3.1.3.12; TPP; Trehalose synthase complex catalytic subunit TPS2; Trehalose-6-phosphate phosphatase", "protein_names_refseq": "trehalose-phosphatase TPS2", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR074W)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "11875433;14562095;14562106;1656215;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;22218487;22814378;23749301;24374639;2546763;32597660;33481703;33491328;8444170;9169867;9194697;9837904", "class_list": "", "function": "Phosphatase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a two step process., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VS60", "ec_number_list": [ { "id": "3.1.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.12", "type": "external" } ], "go_molecular_function": "GO:0004805 trehalose-phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)", "go_biological_process": "GO:0010508 positive regulation of autophagy;GO:0006995 cellular response to nitrogen starvation;GO:0005991 trehalose metabolic process;GO:0005992 trehalose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P31688-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31755-1", "uniprot_id": [ { "id": "OCH1_YEAST", "url": "https://www.uniprot.org/uniprot/P31755", "type": "external" } ], "mass": 55156.0, "length": 480, "protein_name": "Initiation-specific alpha-1,6-mannosyltransferase", "gene_name": "OCH1", "organism": "Yeast", "refseq_name": "initiation-specific alpha-1,6-mannosyltransferase", "refseq_ac": [ { "id": "NP_011477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011477", "type": "external" } ], "gene_names_uniprotkb": "OCH1; NGD29", "gene_names_refseq": "LDB12; NGD29; OCH1", "protein_names_uniprotkb": "Initiation-specific alpha-1,6-mannosyltransferase; 2.4.1.232; Outer chain elongation protein 1", "protein_names_refseq": "initiation-specific alpha-1,6-mannosyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL038C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10880465;11036637;11754484;11854400;14562106;14676282;15229219;1523886;1628616;17042779;17322287;21622726;21979948;24374639;7649302;8253757;8601597;9169869", "class_list": "glycogene;glycosyltransferase", "function": "Mannosyltransferase involved in outer chain elongation of asparagine-linked oligosaccharides of the type Man(9)GlcNAc(2). Adds the first alpha-1,6-mannose to the Man(8)GlcNAc(2) and Man(9)GlcNAc(2), but not Man(5)GlcNAc(2), endoplasmic reticulum intermediates. Represents the first enzymatic event required for synthesis of outer chain mannose linkages on yeast secretory proteins. Also has the potential to transfer a second alpha-1,6-mannose to the Man(8)GlcNAc(2) core oligosaccharide., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VUA1", "ec_number_list": [], "go_molecular_function": "GO:0000009 alpha-1,6-mannosyltransferase activity;GO:0033164 initiation-specific glycolipid 1,6-alpha-mannosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0000137 Golgi cis cisterna;GO:0000136 mannan polymerase complex", "go_biological_process": "GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P31755-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32178-1", "uniprot_id": [ { "id": "CHMU_YEAST", "url": "https://www.uniprot.org/uniprot/P32178", "type": "external" } ], "mass": 29747.0, "length": 256, "protein_name": "Chorismate mutase", "gene_name": "ARO7", "organism": "Yeast", "refseq_name": "chorismate mutase ARO7", "refseq_ac": [ { "id": "NP_015385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015385", "type": "external" } ], "gene_names_uniprotkb": "ARO7; OSM2; YP9499.15C", "gene_names_refseq": "ARO7; HGS1; OSM2; TYR7", "protein_names_uniprotkb": "Chorismate mutase; 5.4.99.5; CM", "protein_names_refseq": "chorismate mutase ARO7", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR060C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10428795;10894726;12455686;17322287;2187528;22814378;24374639;2646272;31498992;33481703;33491328;7971967;8622937;9169875;9384560;9642265", "class_list": "", "function": "Catalyzes the Claisen rearrangement of chorismate to prephenate (PubMed:10428795, PubMed:10894726, PubMed:2187528, PubMed:2646272, PubMed:31498992, PubMed:9642265). Acts at the first branch point in the aromatic amino acid pathway where it steers biosynthesis towards phenylalanine and tyrosine, and away from tryptophan (Probable)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W465", "ec_number_list": [ { "id": "5.4.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.5", "type": "external" } ], "go_molecular_function": "GO:0072545 L-tyrosine binding;GO:0004106 chorismate mutase activity;GO:0120284 tryptophan binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006571 tyrosine biosynthetic process;GO:0046417 chorismate metabolic process;GO:0009073 aromatic amino acid family biosynthetic process;GO:0009094 L-phenylalanine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P32178-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32179-1", "uniprot_id": [ { "id": "MET22_YEAST", "url": "https://www.uniprot.org/uniprot/P32179", "type": "external" } ], "mass": 39149.0, "length": 357, "protein_name": "3'(2'),5'-bisphosphate nucleotidase", "gene_name": "MET22", "organism": "Yeast", "refseq_name": "3'(2'),5'-bisphosphate nucleotidase", "refseq_ac": [ { "id": "NP_014577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014577", "type": "external" } ], "gene_names_uniprotkb": "MET22; HAL2", "gene_names_refseq": "HAL2; MET22", "protein_names_uniprotkb": "3'(2'),5'-bisphosphate nucleotidase; 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase; 3'-phosphoadenosine-5'-phosphatase; 3'-phosphoadenosine-5'-phosphate phosphatase; 3.1.3.7; DPNPase; Halotolerance protein HAL2; Methionine-requiring protein 22; PAP phosphatase; PAPase", "protein_names_refseq": "3'(2'),5'-bisphosphate nucleotidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL064C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10656801;12126627;14562095;14562106;23749301;24374639;33481703;33491328;7809627;8393782;9169874;9178509", "class_list": "", "function": "Phosphatase that converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May regulate the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS (PubMed:7809627). Involved in salt tolerance. Confers resistance to lithium. Shows no activity on inositol mono- and diphosphates, 3'-AMP, AMP, nicotinamide adenine dinucleotide phosphate (NADP), and p-nitrophenylphosphate (PubMed:7809627)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W203;Q6RFY5", "ec_number_list": [ { "id": "3.1.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.7", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016078 tRNA decay;GO:0042538 hyperosmotic salinity response;GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:0009086 methionine biosynthetic process;GO:0000103 sulfate assimilation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P32179-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32259-1", "uniprot_id": [ { "id": "MED16_YEAST", "url": "https://www.uniprot.org/uniprot/P32259", "type": "external" } ], "mass": 111297.0, "length": 974, "protein_name": "Mediator of RNA polymerase II transcription subunit 16", "gene_name": "SIN4", "organism": "Yeast", "refseq_name": "Sin4p", "refseq_ac": [ { "id": "NP_014163", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014163", "type": "external" } ], "gene_names_uniprotkb": "SIN4; BEL2; GAL22; MED16; N1135; RYE1; SDI3; SSF5; SSN4; TSF3", "gene_names_refseq": "BEL2; GAL22; MED16; RYE1; SDI3; SIN4; SSF5; SSN4; SSX3; TSF3", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 16; Global transcriptional regulator SIN4; Mediator complex subunit 16; SNF1 suppressor protein 4; SWI4 suppressor protein 5; Transcriptional silencing factor 3; YGP1 expression regulatory protein 1", "protein_names_refseq": "Sin4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL236W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "12191485;12743037;1406639;14562095;14562106;14749387;15175151;15477388;16002404;16076843;16109375;16263706;17192271;24374639;32597660;33229814;33491328;7479899;8423805;8896273;9169873", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W0V7", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0070202 regulation of establishment of protein localization to chromosome;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P32259-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32266-1", "uniprot_id": [ { "id": "MGM1_YEAST", "url": "https://www.uniprot.org/uniprot/P32266", "type": "external" } ], "mass": 99178.0, "length": 881, "protein_name": "Dynamin-like GTPase MGM1, mitochondrial", "gene_name": "MGM1", "organism": "Yeast", "refseq_name": "dynamin-related GTPase MGM1", "refseq_ac": [ { "id": "NP_014854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014854", "type": "external" } ], "gene_names_uniprotkb": "MGM1; MDM17; YOR50-1", "gene_names_refseq": "MGM1; MNA1", "protein_names_uniprotkb": "Dynamin-like GTPase MGM1, mitochondrial; 3.6.5.5; Mitochondrial division and morphology protein 17; Mitochondrial genome maintenance protein 1", "protein_names_refseq": "dynamin-related GTPase MGM1", "tax_id": 559292, "disease": "mitochondrial DNA depletion syndrome 14 (Disease Ontology:DOID:0080336); dominant optic atrophy plus syndrome (Disease Ontology:DOID:0111340); optic atrophy 1 (Disease Ontology:DOID:0111441); Behr syndrome (Disease Ontology:DOID:0111580); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); transient cerebral ischemia (Disease Ontology:DOID:224); rhinitis (Disease Ontology:DOID:4483); schizophrenia (Disease Ontology:DOID:5419); optic atrophy (Disease Ontology:DOID:5723); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); chronic kidney disease (Disease Ontology:DOID:784); mitochondrial encephalomyopathy (Disease Ontology:DOID:890); ocular hypertension (Disease Ontology:DOID:9282); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (sce:YOR211C); (R-SCE-190873); (R-SCE-196025)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10037792;12566426;12707284;12808034;15087460;15096522;15297626;1532158;16407407;17055438;19236101;19752025;22984289;24374639;31292547;32041880;33491328;7916673;8516295;8840505;9169874", "class_list": "", "function": "Constitutes the soluble short form (S-MGM1) generated by cleavage by PCP1, which plays a central role in mitochondrial inner membrane fusion and cristae morphology (PubMed:12707284, PubMed:15096522, PubMed:19236101, PubMed:32041880). The transmembrane long form (L-MGM1) and the S-MGM1 form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes (By similarity). Inner membrane-anchored L-MGM1 molecules initiate membrane remodeling by recruiting soluble S-MGM1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane (By similarity). Once at the membrane surface, the formation of S-MGM1 helices induce bilayer curvature (By similarity). MGM1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible MGM1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion (PubMed:19752025, PubMed:31292547, PubMed:32041880). Excess levels of S-MGM1 produced by cleavage by PCP1 following stress conditions that induce loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-MGM1 and S-MGM1, thereby inhibiting mitochondrial fusion (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Constitutes the transmembrane long form (L-MGM1) that plays a central role in mitochondrial inner membrane fusion and cristae morphology (PubMed:12707284, PubMed:15096522, PubMed:19236101, PubMed:19752025, PubMed:32041880). L-MGM1 and the soluble short form (S-MGM1) form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes (By similarity). Inner membrane-anchored L-MGM1 molecules initiate membrane remodeling by recruiting soluble S-MGM1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane (By similarity). Once at the membrane surface, the formation of S-MGM1 helices induce bilayer curvature (By similarity). MGM1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible MGM1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion (PubMed:19752025, PubMed:31292547, PubMed:32041880)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Dynamin-related GTPase that is essential for normal mitochondrial morphology by mediating fusion of the mitochondrial inner membranes, regulating cristae morphology and maintaining respiratory chain function (PubMed:10037792, PubMed:12566426, PubMed:12707284, PubMed:15087460, PubMed:15297626, PubMed:17055438, PubMed:19236101, PubMed:19752025, PubMed:32041880). Exists in two forms: the transmembrane, long form (Dynamin-like GTPase MGM1, long form; L-MGM1), which is tethered to the inner mitochondrial membrane, and the short soluble form (Dynamin-like GTPase MGM1, short form; S-MGM1), which results from proteolytic cleavage and localizes in the intermembrane space (PubMed:12707284, PubMed:15096522, PubMed:19752025). Both forms (L-MGM1 and S-MGM1) cooperate to catalyze the fusion of the mitochondrial inner membrane (PubMed:12707284, PubMed:15096522, PubMed:17055438). The equilibrium between L-MGM1 and S-MGM1 is essential: excess levels of S-MGM1, following loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-MGM1 and S-MGM1, inhibiting mitochondrial fusion (By similarity). Plays a role in the maintenance and remodeling of mitochondrial cristae, some invaginations of the mitochondrial inner membrane that provide an increase in the surface area (PubMed:31292547). Probably acts by forming helical filaments at the inside of inner membrane tubes with the shape and dimensions of crista junctions (PubMed:31292547)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 22, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2R7;Q02609;Q08627", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0046872 metal ion binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0097749 membrane tubulation;GO:0097753 membrane bending;GO:0015886 heme transport;GO:0007005 mitochondrion organization;GO:0008053 mitochondrial fusion", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P32266-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32288-1", "uniprot_id": [ { "id": "GLNA_YEAST", "url": "https://www.uniprot.org/uniprot/P32288", "type": "external" } ], "mass": 41766.0, "length": 370, "protein_name": "Glutamine synthetase", "gene_name": "GLN1", "organism": "Yeast", "refseq_name": "glutamate--ammonia ligase", "refseq_ac": [ { "id": "NP_015360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015360", "type": "external" } ], "gene_names_uniprotkb": "GLN1; YP3085.01; YP9367.15", "gene_names_refseq": "GLN1", "protein_names_uniprotkb": "Glutamine synthetase; 6.3.1.2; GS; Glutamate--ammonia ligase", "protein_names_refseq": "glutamate--ammonia ligase", "tax_id": 559292, "disease": "congenital glutamine deficiency (Disease Ontology:DOID:0070544); developmental and epileptic encephalopathy 116 (Disease Ontology:DOID:0070545); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); heart disease (Disease Ontology:DOID:114); Huntington's disease (Disease Ontology:DOID:12858); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); liver disease (Disease Ontology:DOID:409); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); diabetic retinopathy (Disease Ontology:DOID:8947); amino acid metabolic disorder (Disease Ontology:DOID:9252); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YPR035W); (R-SCE-210455); (R-SCE-8964539)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "12872131;1347768;14557538;14562095;14562106;15665377;19779198;22106047;22814378;24374639;2891705;32597660;33481703;33491328;9169875;9298649", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W445;Q03959", "ec_number_list": [ { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004356 glutamine synthetase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0034399 nuclear periphery", "go_biological_process": "GO:0006542 glutamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P32288-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32316-1", "uniprot_id": [ { "id": "ACH1_YEAST", "url": "https://www.uniprot.org/uniprot/P32316", "type": "external" } ], "mass": 58712.0, "length": 526, "protein_name": "Acetyl-CoA hydrolase", "gene_name": "ACH1", "organism": "Yeast", "refseq_name": "acetyl-CoA hydrolase", "refseq_ac": [ { "id": "NP_009538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009538", "type": "external" } ], "gene_names_uniprotkb": "ACH1; YBL03.18; YBL0304", "gene_names_refseq": "ACH1", "protein_names_uniprotkb": "Acetyl-CoA hydrolase; 3.1.2.1; Acetyl-CoA acylase; Acetyl-CoA deacylase", "protein_names_refseq": "acetyl-CoA hydrolase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL015W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11502169;1441754;14562106;17761666;1970569;22814378;24374639;33491328;7813418", "class_list": "", "function": "Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation. It may be involved in overall regulation of acetylation during melatonin synthesis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VPY5", "ec_number_list": [ { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "2.3.1.268", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.268", "type": "external" } ], "go_molecular_function": "GO:0003986 acetyl-CoA hydrolase activity;GO:0008775 acetate CoA-transferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006083 acetate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P32316-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32318-1", "uniprot_id": [ { "id": "THI4_YEAST", "url": "https://www.uniprot.org/uniprot/P32318", "type": "external" } ], "mass": 34991.0, "length": 326, "protein_name": "Thiamine thiazole synthase", "gene_name": "THI4", "organism": "Yeast", "refseq_name": "thiamine thiazole synthase", "refseq_ac": [ { "id": "NP_011660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011660", "type": "external" } ], "gene_names_uniprotkb": "THI4; ESP35; G6620; MOL1", "gene_names_refseq": "ESP35; MOL1; THI4", "protein_names_uniprotkb": "Thiamine thiazole synthase; 2.4.2.60; Thiazole biosynthetic enzyme", "protein_names_refseq": "thiamine thiazole synthase", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR144W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "1441749;15544818;16171982;16734458;16850348;16964967;17309261;18652458;22031445;24374639;7941734;8585325;9169869;9367751", "class_list": "", "function": "Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance., [UniProtKB, PubMed, PubMed, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUS4", "ec_number_list": [ { "id": "2.4.2.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.60", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0008198 ferrous iron binding;GO:0160205 cysteine-dependent adenosine diphosphate thiazole synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0052837 thiazole biosynthetic process;GO:0009228 thiamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P32318-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32319-1", "uniprot_id": [ { "id": "VPS10_YEAST", "url": "https://www.uniprot.org/uniprot/P32319", "type": "external" } ], "mass": 177777.0, "length": 1579, "protein_name": "Vacuolar protein sorting/targeting protein VPS10", "gene_name": "PEP1", "organism": "Yeast", "refseq_name": "type I sorting receptor", "refseq_ac": [ { "id": "NP_009536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009536", "type": "external" } ], "gene_names_uniprotkb": "PEP1; VPS10; VPT1; YBL03.22; YBL0302", "gene_names_refseq": "PEP1; VPS10; VPT1", "protein_names_uniprotkb": "Vacuolar protein sorting/targeting protein VPS10; CPY receptor; Carboxypeptidase Y receptor; Carboxypeptidase Y-deficient protein 1; Sortilin VPS10; Vacuolar carboxypeptidase sorting receptor VPS10; Vacuolar protein sorting-associated protein 10; Vacuolar protein-targeting protein 1", "protein_names_refseq": "type I sorting receptor", "tax_id": 559292, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); proteinuria (Disease Ontology:DOID:576); abdominal aortic aneurysm (Disease Ontology:DOID:7693)", "pathway": " (sce:YBL017C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10095782;1441754;14562106;24374639;3062374;33491328;3538017;7813418;8187177;8534908;8636229;8662642", "class_list": "", "function": "Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. May execute multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment. Binds the Golgi-modified P2 form of CPY, and this interaction is dependent on the presence of an intact CPY vacuolar protein sorting signal., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6VPY3", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0010209 vacuolar sorting signal binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0007034 vacuolar transport;GO:0006895 Golgi to endosome transport;GO:0048203 vesicle targeting, trans-Golgi to endosome;GO:0000423 mitophagy;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P32319-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32323-1", "uniprot_id": [ { "id": "AGA1_YEAST", "url": "https://www.uniprot.org/uniprot/P32323", "type": "external" } ], "mass": 73354.0, "length": 725, "protein_name": "A-agglutinin anchorage subunit", "gene_name": "AGA1", "organism": "Yeast", "refseq_name": "Aga1p", "refseq_ac": [ { "id": "NP_014442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014442", "type": "external" } ], "gene_names_uniprotkb": "AGA1; N3431", "gene_names_refseq": "AGA1", "protein_names_uniprotkb": "A-agglutinin anchorage subunit; A-agglutinin cell wall attachment subunit", "protein_names_refseq": "Aga1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNR044W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11278672;14555493;16086015;2072914;24374639;7957044;9169873", "class_list": "", "function": "Cell wall anchoring subunit of the a-agglutinin heterodimer. S.cerevisiae a and alpha cells express the complementary cell surface glycoproteins a-agglutinin and alpha-agglutinin, respectively, which interact with one another to promote cellular aggregation during mating., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W1L9", "ec_number_list": [], "go_molecular_function": "GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0071944 cell periphery;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0000752 agglutination involved in conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32323-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32327-1", "uniprot_id": [ { "id": "PYC2_YEAST", "url": "https://www.uniprot.org/uniprot/P32327", "type": "external" } ], "mass": 130167.0, "length": 1180, "protein_name": "Pyruvate carboxylase 2", "gene_name": "PYC2", "organism": "Yeast", "refseq_name": "pyruvate carboxylase 2", "refseq_ac": [ { "id": "NP_009777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009777", "type": "external" } ], "gene_names_uniprotkb": "PYC2; YBR1507", "gene_names_refseq": "PYC2", "protein_names_uniprotkb": "Pyruvate carboxylase 2; 6.4.1.1; PCB 2; Pyruvic carboxylase 2", "protein_names_refseq": "pyruvate carboxylase 2", "tax_id": 559292, "disease": "pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649); pyruvate carboxylase deficiency disease (Disease Ontology:DOID:3651)", "pathway": " (sce:YBR218C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562106;18407956;1921979;19779198;22814378;23749301;24374639;32597660;33481703;33491328;7813418;8554526", "class_list": "", "function": "Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VQL4", "ec_number_list": [ { "id": "6.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004736 pyruvate carboxylase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006094 gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P32327-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32328-1", "uniprot_id": [ { "id": "DBF20_YEAST", "url": "https://www.uniprot.org/uniprot/P32328", "type": "external" } ], "mass": 65880.0, "length": 564, "protein_name": "Serine/threonine-protein kinase DBF20", "gene_name": "DBF20", "organism": "Yeast", "refseq_name": "serine/threonine-protein kinase DBF20", "refseq_ac": [ { "id": "NP_015436", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015436", "type": "external" } ], "gene_names_uniprotkb": "DBF20", "gene_names_refseq": "DBF20", "protein_names_uniprotkb": "Serine/threonine-protein kinase DBF20; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase DBF20", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR111W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14562106;17287358;17322287;18407956;1916278;19779198;19795423;19823750;20489023;20702584;21177495;24374639;32597660;33481703;33491328;9169875", "class_list": "", "function": "Is probably a Ser/Thr-protein kinase that may function in initiation of DNA synthesis and also in late nuclear division., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4B0;E9P8X8;Q06105", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005816 spindle pole body;GO:0034973 Sid2-Mob1 complex;GO:0005935 cellular bud neck", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0010458 exit from mitosis;GO:0000281 mitotic cytokinesis;GO:0007096 regulation of exit from mitosis;GO:0000917 division septum assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P32328-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32329-1", "uniprot_id": [ { "id": "YPS1_YEAST", "url": "https://www.uniprot.org/uniprot/P32329", "type": "external" } ], "mass": 60010.0, "length": 569, "protein_name": "Aspartic proteinase 3", "gene_name": "YPS1", "organism": "Yeast", "refseq_name": "aspartyl protease", "refseq_ac": [ { "id": "NP_013221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013221", "type": "external" } ], "gene_names_uniprotkb": "YPS1; L2961; L9233.9; YAP3", "gene_names_refseq": "YAP3; YPS1", "protein_names_uniprotkb": "Aspartic proteinase 3; 3.4.23.41; Proprotein convertase; Yapsin-1", "protein_names_refseq": "aspartyl protease", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR120C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11737827;14562106;14617149;16087741;18573178;18591427;2183521;24374639;7657670;7779785;8389368;9090053;9169871;9417119;9485427", "class_list": "", "function": "Cleaves proteins C-terminally to mono- and paired-basic residues. Involved in the shedding of a subset of GPI-anchored plasma membrane proteins from the cell surface, including itself, GAS1 and MSB2. May also play a role in the maturation of GPI-mannoproteins associated with the cell wall. Can process the alpha-mating factor precursor. Required for cell wall integrity., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 10, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "D6VYB8;Q12419", "ec_number_list": [], "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0016485 protein processing;GO:0001402 signal transduction involved in filamentous growth;GO:0007323 peptide pheromone maturation;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P32329-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32332-1", "uniprot_id": [ { "id": "OAC1_YEAST", "url": "https://www.uniprot.org/uniprot/P32332", "type": "external" } ], "mass": 35153.0, "length": 324, "protein_name": "Mitochondrial oxaloacetate transport protein", "gene_name": "OAC1", "organism": "Yeast", "refseq_name": "Oac1p", "refseq_ac": [ { "id": "NP_012802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012802", "type": "external" } ], "gene_names_uniprotkb": "OAC1; PMT1; PMT; YKL522", "gene_names_refseq": "OAC1", "protein_names_uniprotkb": "Mitochondrial oxaloacetate transport protein; Mitochondrial carrier protein PMT", "protein_names_refseq": "Oac1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL120W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10428783;14562106;1514329;18682385;24374639;8196765", "class_list": "", "function": "Antiporter that exchanges dicarboxylates and sulfur oxoanions across the inner membrane of mitochondria. Exports alpha-isopropylmalate from mitochondrial matrix to the cytosol, where it serves as a precursor for leucine biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXH0", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity;GO:0015131 oxaloacetate transmembrane transporter activity;GO:0034658 isopropylmalate transmembrane transporter activity;GO:1901239 malonate(1-) transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:1902358 sulfate transmembrane transport;GO:0015729 oxaloacetate transport;GO:0034659 isopropylmalate transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P32332-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32334-1", "uniprot_id": [ { "id": "MSB2_YEAST", "url": "https://www.uniprot.org/uniprot/P32334", "type": "external" } ], "mass": 133115.0, "length": 1306, "protein_name": "Signaling mucin MSB2", "gene_name": "MSB2", "organism": "Yeast", "refseq_name": "Msb2p", "refseq_ac": [ { "id": "NP_011528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011528", "type": "external" } ], "gene_names_uniprotkb": "MSB2", "gene_names_refseq": "MSB2", "protein_names_uniprotkb": "Signaling mucin MSB2; Multicopy suppressor of bud emergence 2; Osmosensor MSB2", "protein_names_refseq": "Msb2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR014W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12052881;14562106;1514328;15256499;15713635;19439450;19779198;19795423;19823750;23749301;24374639;2690082;30516470;32597660;33481703;33491328;9169869;9290212", "class_list": "", "function": "Plasma membrane signaling mucin that promotes activation of the MAPK for the filamentous growth pathway. Partially redundant with the SHO1 osmosensing branch for the activation of STE11., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "D6VUF0", "ec_number_list": [], "go_molecular_function": "GO:0005034 osmosensor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030427 site of polarized growth", "go_biological_process": "GO:0006970 response to osmotic stress;GO:0030010 establishment of cell polarity;GO:0006972 hyperosmotic response;GO:0000282 cellular bud site selection;GO:0001402 signal transduction involved in filamentous growth", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P32334-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32335-1", "uniprot_id": [ { "id": "MSS51_YEAST", "url": "https://www.uniprot.org/uniprot/P32335", "type": "external" } ], "mass": 50880.0, "length": 436, "protein_name": "Protein MSS51, mitochondrial", "gene_name": "MSS51", "organism": "Yeast", "refseq_name": "Mss51p", "refseq_ac": [ { "id": "NP_013304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013304", "type": "external" } ], "gene_names_uniprotkb": "MSS51; L8167.17", "gene_names_refseq": "MSS51", "protein_names_uniprotkb": "Protein MSS51, mitochondrial; Mitochondrial splicing suppressor protein 51", "protein_names_refseq": "Mss51p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR203C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10803883;11782424;14562095;14562106;14576278;14592991;1523888;15306853;2177521;23749301;24374639;33481703;33491328;6297789;6320175;9169871", "class_list": "", "function": "Has a dual role in the assembly of cytochrome oxidase subunit 1 (COX1). It has a regulative function on COX1 synthesis, acting as a translational activator specific for the COX1 mRNA, and it also binds to newly synthesized COX1 protein. Together with COX14, may act as a chaperone that binds efficiently unassembled COX1 and prevents it from unproductive aggregation. When bound to COX1, MSS51 is unable to interact with the COX1 mRNA and translation is halted. This may be a feedback control that ensures that COX1 is only produced as long as potentially harmful assembly intermediates are not accumulating., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VYK4", "ec_number_list": [], "go_molecular_function": "GO:0045182 translation regulator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006397 mRNA processing;GO:0050821 protein stabilization;GO:0008380 RNA splicing;GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0070131 positive regulation of mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P32335-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32336-1", "uniprot_id": [ { "id": "NUD1_YEAST", "url": "https://www.uniprot.org/uniprot/P32336", "type": "external" } ], "mass": 94104.0, "length": 851, "protein_name": "Protein NUD1", "gene_name": "NUD1", "organism": "Yeast", "refseq_name": "Nud1p", "refseq_ac": [ { "id": "NP_015018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015018", "type": "external" } ], "gene_names_uniprotkb": "NUD1", "gene_names_refseq": "CDC18; NUD1", "protein_names_uniprotkb": "Protein NUD1", "protein_names_refseq": "Nud1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR373W)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10330408;10899120;11101520;11742972;11973299;12796288;14562106;17287358;18407956;19779198;19795423;19823750;21177495;22106047;22218487;23749301;24374639;30516470;32597660;32851976;33481703;33491328;9169874;9571234;9585415", "class_list": "", "function": "Involved in astral microtubule organization by binding SCP72 to the outer plaque in a cell-cycle dependent manner. Required for the mitotic exit by facilitating the binding of TEMP1 to CDC15. Also involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 29, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W366;Q08895", "ec_number_list": [], "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005777 peroxisome;GO:0061499 outer plaque of mitotic spindle pole body", "go_biological_process": "GO:0051293 establishment of spindle localization;GO:0051301 cell division;GO:1902412 regulation of mitotic cytokinesis;GO:0031536 positive regulation of exit from mitosis;GO:0045132 meiotic chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P32336-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32338-1", "uniprot_id": [ { "id": "RME1_YEAST", "url": "https://www.uniprot.org/uniprot/P32338", "type": "external" } ], "mass": 33904.0, "length": 300, "protein_name": "Zinc finger protein RME1", "gene_name": "RME1", "organism": "Yeast", "refseq_name": "Rme1p", "refseq_ac": [ { "id": "NP_011558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011558", "type": "external" } ], "gene_names_uniprotkb": "RME1", "gene_names_refseq": "CSP1; RME1", "protein_names_uniprotkb": "Zinc finger protein RME1", "protein_names_refseq": "Rme1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR044C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1936989;24374639;33481703;33491328;8339935;8846775;9169869", "class_list": "", "function": "Involved in the control of meiosis. Represses the transcription of the IME1 gene thereby inhibiting cells from entering meiosis. But also activates the CLN2 gene thus promoting mitosis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUI2;Q45TA6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32338-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32340-1", "uniprot_id": [ { "id": "NDI1_YEAST", "url": "https://www.uniprot.org/uniprot/P32340", "type": "external" } ], "mass": 57250.0, "length": 513, "protein_name": "Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial", "gene_name": "NDI1", "organism": "Yeast", "refseq_name": "NADH-ubiquinone reductase (H(+)-translocating) NDI1", "refseq_ac": [ { "id": "NP_013586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013586", "type": "external" } ], "gene_names_uniprotkb": "NDI1; YM7056.06C", "gene_names_refseq": "NDI1", "protein_names_uniprotkb": "Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial; 1.6.5.9; Internal NADH dehydrogenase; NADH:ubiquinone reductase (non-electrogenic)", "protein_names_refseq": "NADH-ubiquinone reductase (H(+)-translocating) NDI1", "tax_id": 559292, "disease": "Leber hereditary optic neuropathy (Disease Ontology:DOID:705)", "pathway": " (sce:YML120C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11502169;14562106;17322287;1735444;17761666;24374639;9169872", "class_list": "", "function": "Catalyzes the oxidation of NADH generated inside the Mitochondrion., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W0G4", "ec_number_list": [ { "id": "1.6.5.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.9", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0016491 oxidoreductase activity;GO:0120555 NADH dehydrogenase (ubiquinone) (non-electrogenic) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32340-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32342-1", "uniprot_id": [ { "id": "SRP21_YEAST", "url": "https://www.uniprot.org/uniprot/P32342", "type": "external" } ], "mass": 18425.0, "length": 167, "protein_name": "Signal recognition particle subunit SRP21", "gene_name": "SRP21", "organism": "Yeast", "refseq_name": "signal recognition particle subunit SRP21", "refseq_ac": [ { "id": "NP_012800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012800", "type": "external" } ], "gene_names_uniprotkb": "SRP21; YKL527", "gene_names_refseq": "SRP21", "protein_names_uniprotkb": "Signal recognition particle subunit SRP21; Signal recognition particle 21 kDa protein", "protein_names_refseq": "signal recognition particle subunit SRP21", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL122C); (R-SCE-1799339)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11352936;14562106;1514329;17287358;17322287;22814378;23749301;24374639;33491328;7925282;8196765;8707814", "class_list": "", "function": "Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VXG8", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005634 nucleus", "go_biological_process": "GO:0006614 SRP-dependent cotranslational protein targeting to membrane;GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P32342-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32345-1", "uniprot_id": [ { "id": "PP4C_YEAST", "url": "https://www.uniprot.org/uniprot/P32345", "type": "external" } ], "mass": 35264.0, "length": 308, "protein_name": "Serine/threonine-protein phosphatase 4 catalytic subunit", "gene_name": "PPH3", "organism": "Yeast", "refseq_name": "phosphoprotein phosphatase PP4 catalytic subunit PPH3", "refseq_ac": [ { "id": "NP_010360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010360", "type": "external" } ], "gene_names_uniprotkb": "PPH3; D4421", "gene_names_refseq": "PPH3", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 4 catalytic subunit; 3.1.3.16; PP4C; Phosphatase PP2A-like catalytic subunit PPH3", "protein_names_refseq": "phosphoprotein phosphatase PP4 catalytic subunit PPH3", "tax_id": 559292, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (sce:YDR075W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10940301;14551259;14562095;14562106;15447631;16085932;16299494;1656215;17322287;22814378;24374639;7941742;9169867", "class_list": "", "function": "Forms the histone H2A phosphatase complex in association with the regulatory subunits PSY2 and PSY4, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint. PPH3 is directly involved in the dephosphorylation and activation of the transcription factor GLN3 in response to nutrient availability., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS61", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.43", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0034399 nuclear periphery;GO:0030289 protein phosphatase 4 complex", "go_biological_process": "GO:0051598 meiotic recombination checkpoint signaling;GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0000724 double-strand break repair via homologous recombination;GO:2000002 negative regulation of DNA damage checkpoint;GO:1903432 regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P32345-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32347-1", "uniprot_id": [ { "id": "DCUP_YEAST", "url": "https://www.uniprot.org/uniprot/P32347", "type": "external" } ], "mass": 41349.0, "length": 362, "protein_name": "Uroporphyrinogen decarboxylase", "gene_name": "HEM12", "organism": "Yeast", "refseq_name": "uroporphyrinogen decarboxylase HEM12", "refseq_ac": [ { "id": "NP_010332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010332", "type": "external" } ], "gene_names_uniprotkb": "HEM12; HEM6; POP3; YD9609.03", "gene_names_refseq": "HEM12; HEM6", "protein_names_uniprotkb": "Uroporphyrinogen decarboxylase; 4.1.1.37; Porphyrinogen carboxylyase; UPD; URO-D", "protein_names_refseq": "uroporphyrinogen decarboxylase HEM12", "tax_id": 559292, "disease": "porphyria (Disease Ontology:DOID:13268); breast cancer (Disease Ontology:DOID:1612); porphyria cutanea tarda (Disease Ontology:DOID:3132); hepatoerythropoietic porphyria (Disease Ontology:DOID:5230)", "pathway": " (sce:YDR047W); (R-SCE-189451)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "14559249;14562095;14562106;1471989;1576986;2180703;22814378;24374639;26317124;7035824;8346678;9169867", "class_list": "", "function": "Catalyzes the sequential decarboxylation of four acetate groups of uroporphyrinogen-III (octacarboxyporphyrin) to yield coproporphyrinogen-III (tetracarboxyporphyrin) with the formation of intermediate hepta-, hexa- and penta-carboxylate porphyrinogens in the heme biosynthesis pathway. Acts on a number of porphyrinogens, but only coproporphyrinogen III can ultimately be converted to heme., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS35", "ec_number_list": [ { "id": "4.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.37", "type": "external" } ], "go_molecular_function": "GO:0004853 uroporphyrinogen decarboxylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P32347-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32349-1", "uniprot_id": [ { "id": "RPC3_YEAST", "url": "https://www.uniprot.org/uniprot/P32349", "type": "external" } ], "mass": 74017.0, "length": 654, "protein_name": "DNA-directed RNA polymerase III subunit RPC3", "gene_name": "RPC82", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase III subunit C82", "refseq_ac": [ { "id": "NP_015516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015516", "type": "external" } ], "gene_names_uniprotkb": "RPC82; P9677.11; RPC3", "gene_names_refseq": "RPC3; RPC80; RPC82", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC3; C74; C82; DNA-directed III 74 kDa polypeptide; RNA polymerase III subunit C3", "protein_names_refseq": "DNA-directed RNA polymerase III subunit C82", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR190C); (R-SCE-76061); (R-SCE-76066)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10384303;1406632;14562095;14562106;17287358;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;23749301;24374639;32597660;33481703;33491328;9169875", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4J0;Q06591", "ec_number_list": [], "go_molecular_function": "GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0042797 tRNA transcription by RNA polymerase III;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P32349-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32350-1", "uniprot_id": [ { "id": "KNS1_YEAST", "url": "https://www.uniprot.org/uniprot/P32350", "type": "external" } ], "mass": 83843.0, "length": 737, "protein_name": "Dual specificity protein kinase KNS1", "gene_name": "KNS1", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase KNS1", "refseq_ac": [ { "id": "NP_013081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013081", "type": "external" } ], "gene_names_uniprotkb": "KNS1", "gene_names_refseq": "KNS1", "protein_names_uniprotkb": "Dual specificity protein kinase KNS1; 2.7.12.1", "protein_names_refseq": "serine/threonine protein kinase KNS1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLL019C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11741326;17563356;18407956;1910150;19779198;19795423;19823750;20489023;21126336;23749301;24374639;27821475;32597660;33481703;33491328;8910305;9046100;9169871", "class_list": "", "function": "Nonessential protein kinase., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXY4;Q12399", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043484 regulation of RNA splicing;GO:0016480 negative regulation of transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P32350-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32353-1", "uniprot_id": [ { "id": "ERG3_YEAST", "url": "https://www.uniprot.org/uniprot/P32353", "type": "external" } ], "mass": 42730.0, "length": 365, "protein_name": "Delta(7)-sterol 5(6)-desaturase ERG3", "gene_name": "ERG3", "organism": "Yeast", "refseq_name": "C-5 sterol desaturase", "refseq_ac": [ { "id": "NP_013157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013157", "type": "external" } ], "gene_names_uniprotkb": "ERG3; L2150; PSO6; SYR1", "gene_names_refseq": "ERG3; PSO6; SYR1", "protein_names_uniprotkb": "Delta(7)-sterol 5(6)-desaturase ERG3; 1.14.19.20; C-5 sterol desaturase ERG3; Ergosterol Delta(5,6) desaturase ERG3; Ergosterol biosynthetic protein 3; Sterol-C5-desaturase", "protein_names_refseq": "C-5 sterol desaturase", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR056W); (R-SCE-6807047)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12872131;14562106;15995173;16847258;17322287;1864507;24374639;32679672;37604855;8180700;8772195;9169871", "class_list": "", "function": "C-5 sterol desaturase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:1864507). ERG3 catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol (PubMed:1864507). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25. Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (PubMed:32679672)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY58", "ec_number_list": [ { "id": "1.14.19.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.20", "type": "external" } ], "go_molecular_function": "GO:0000248 C-5 sterol desaturase activity;GO:0005506 iron ion binding;GO:0050046 delta7-sterol 5(6)-desaturase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006696 ergosterol biosynthetic process;GO:0016126 sterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P32353-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32356-1", "uniprot_id": [ { "id": "TREA_YEAST", "url": "https://www.uniprot.org/uniprot/P32356", "type": "external" } ], "mass": 85879.0, "length": 751, "protein_name": "Cytosolic neutral trehalase", "gene_name": "NTH1", "organism": "Yeast", "refseq_name": "alpha,alpha-trehalase NTH1", "refseq_ac": [ { "id": "NP_010284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010284", "type": "external" } ], "gene_names_uniprotkb": "NTH1; NTH; YD8119.07C", "gene_names_refseq": "NTH1", "protein_names_uniprotkb": "Cytosolic neutral trehalase; 3.2.1.28; Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase", "protein_names_refseq": "alpha,alpha-trehalase NTH1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR001C)", "pathway_count": 1, "publication_count": 41, "publication_id_list": "10527941;11875433;14562095;14562106;15665377;17287358;17330950;17563356;17916074;18407956;19684113;19779198;19795423;19823750;20639203;20702584;21177495;22218487;22320399;22814378;23749301;24374639;2507544;27203178;27203179;28270554;29087344;30516470;32102971;32597660;33229814;33441790;33481703;33491328;3537685;7730323;7821816;7883049;8444853;9169867;9276477", "class_list": "glycogene;glycosylhydrolase", "function": "Hydrolyzes intracellular trehalose to glucose (Probable) (PubMed:22320399, PubMed:29087344). The disaccharide trehalose serves as a storage carbohydrate that is mobilized during nutrient stress (Probable). Regulates the level of trehalose as a protectant for cell integrity during heat stress (PubMed:7730323, PubMed:7883049)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VRY8;E9P9U7", "ec_number_list": [ { "id": "3.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.28", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004555 alpha,alpha-trehalase activity;GO:0015927 trehalase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0005993 trehalose catabolic process;GO:0071465 cellular response to desiccation", "synthesized_glycan_count": 0, "hit_score": 4.8, "record_id": "P32356-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0100000000001.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32363-1", "uniprot_id": [ { "id": "GPI3_YEAST", "url": "https://www.uniprot.org/uniprot/P32363", "type": "external" } ], "mass": 51242.0, "length": 452, "protein_name": "Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit", "gene_name": "SPT14", "organism": "Yeast", "refseq_name": "phosphatidylinositol N-acetylglucosaminyltransferase SPT14", "refseq_ac": [ { "id": "NP_015150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015150", "type": "external" } ], "gene_names_uniprotkb": "SPT14; CWH6; GPI3; P2269", "gene_names_refseq": "CWH6; GPI3; SPT14", "protein_names_uniprotkb": "Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit; 2.4.1.198; GPI-GlcNAc transferase complex subunit GPI3; GPI-GnT subunit GPI3; GlcNAc-PI synthesis protein", "protein_names_refseq": "phosphatidylinositol N-acetylglucosaminyltransferase SPT14", "tax_id": 559292, "disease": "paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); autosomal recessive congenital ichthyosis 4B (Disease Ontology:DOID:0060713); multiple congenital anomalies-hypotonia-seizures syndrome 2 (Disease Ontology:DOID:0080139)", "pathway": " (sce:YPL175W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10734188;10970797;14562106;14622279;15163411;1660567;21126336;23749301;24374639;33491328;7737116;7768896;9169875", "class_list": "glycogene;glycosyltransferase", "function": "Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3J3;Q08918", "ec_number_list": [ { "id": "2.4.1.198", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.198", "type": "external" } ], "go_molecular_function": "GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P32363-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32364-1", "uniprot_id": [ { "id": "SMY1_YEAST", "url": "https://www.uniprot.org/uniprot/P32364", "type": "external" } ], "mass": 73799.0, "length": 656, "protein_name": "Kinesin-related protein SMY1", "gene_name": "SMY1", "organism": "Yeast", "refseq_name": "Smy1p", "refseq_ac": [ { "id": "NP_012844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012844", "type": "external" } ], "gene_names_uniprotkb": "SMY1; YKL409", "gene_names_refseq": "SMY1", "protein_names_uniprotkb": "Kinesin-related protein SMY1; Suppressor protein SMY1", "protein_names_refseq": "Smy1p", "tax_id": 559292, "disease": "familial restrictive cardiomyopathy 6 (Disease Ontology:DOID:0061025); hereditary spastic paraplegia 10 (Disease Ontology:DOID:0110763); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (sce:YKL079W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "14562106;1549181;17287358;1730668;17330950;18407956;19684113;19779198;19795423;19823750;21177495;23749301;24374639;32597660;33229814;33481703;33491328;8196765;8203165", "class_list": "", "function": "Possible microtubule-based motor that can interact or substitute with myosin 2 (MYO2)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6VXK8", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0008574 plus-end-directed microtubule motor activity;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005871 kinesin complex;GO:0000131 incipient cellular bud site;GO:0005934 cellular bud tip", "go_biological_process": "GO:0007018 microtubule-based movement;GO:0030705 cytoskeleton-dependent intracellular transport;GO:0006904 vesicle docking involved in exocytosis", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P32364-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32367-1", "uniprot_id": [ { "id": "TFC1_YEAST", "url": "https://www.uniprot.org/uniprot/P32367", "type": "external" } ], "mass": 73554.0, "length": 649, "protein_name": "Transcription factor tau 95 kDa subunit", "gene_name": "TFC1", "organism": "Yeast", "refseq_name": "transcription factor TFIIIC subunit TFC1", "refseq_ac": [ { "id": "NP_009681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009681", "type": "external" } ], "gene_names_uniprotkb": "TFC1; YBR0919", "gene_names_refseq": "TFC1", "protein_names_uniprotkb": "Transcription factor tau 95 kDa subunit; TFIIIC 95 kDa subunit; Transcription factor C subunit 1", "protein_names_refseq": "transcription factor TFIIIC subunit TFC1", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR123C); (R-SCE-76061); (R-SCE-76066)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "12533520;14562095;14562106;1737746;18407956;2052571;2180956;24374639;33481703;33491328;7688737;7813418;7900426;9335584", "class_list": "", "function": "TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. Participates in the interconnection of tauA with tauB via its contacts with TFC3 and TFC6. Serves as a scaffold critical for tauA-DNA spatial configuration and tauB-DNA stability., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQC1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000995 RNA polymerase III general transcription initiation factor activity", "go_cellular_component": "GO:0000127 transcription factor TFIIIC complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0042791 5S class rRNA transcription by RNA polymerase III;GO:0006383 transcription by RNA polymerase III;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P32367-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32377-1", "uniprot_id": [ { "id": "MVD1_YEAST", "url": "https://www.uniprot.org/uniprot/P32377", "type": "external" } ], "mass": 44116.0, "length": 396, "protein_name": "Diphosphomevalonate decarboxylase", "gene_name": "MVD1", "organism": "Yeast", "refseq_name": "diphosphomevalonate decarboxylase MVD1", "refseq_ac": [ { "id": "NP_014441", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014441", "type": "external" } ], "gene_names_uniprotkb": "MVD1; ERG19; MPD; N3427", "gene_names_refseq": "ERG19; MVD1", "protein_names_uniprotkb": "Diphosphomevalonate decarboxylase; 4.1.1.33; Ergosterol biosynthesis protein 19; MDDase; MDD; MPD; Mevalonate pyrophosphate decarboxylase; Mevalonate-5-diphosphate decarboxylase", "protein_names_refseq": "diphosphomevalonate decarboxylase MVD1", "tax_id": 559292, "disease": "porokeratosis (Disease Ontology:DOID:3805)", "pathway": " (sce:YNR043W); (R-SCE-446199); (R-SCE-9969896)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "11698677;14562106;17322287;1740455;18407956;24374639;32679672;33481703;33491328;8626466;9169873;9244250", "class_list": "", "function": "Diphosphomevalonate decarboxylase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (PubMed:8626466, PubMed:9244250). MVD1/ERG19 converts diphosphomevalonate into isopentenyl diphosphate (PubMed:8626466). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD1/ERG19 then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (PubMed:32679672)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1L8;Q6B1C8", "ec_number_list": [ { "id": "4.1.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.33", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004163 diphosphomevalonate decarboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005773 vacuole", "go_biological_process": "GO:0006696 ergosterol biosynthetic process;GO:0016126 sterol biosynthetic process;GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P32377-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32378-1", "uniprot_id": [ { "id": "COQ2_YEAST", "url": "https://www.uniprot.org/uniprot/P32378", "type": "external" } ], "mass": 41001.0, "length": 372, "protein_name": "4-hydroxybenzoate polyprenyltransferase, mitochondrial", "gene_name": "COQ2", "organism": "Yeast", "refseq_name": "4-hydroxybenzoate octaprenyltransferase", "refseq_ac": [ { "id": "NP_014439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014439", "type": "external" } ], "gene_names_uniprotkb": "COQ2; N3419", "gene_names_refseq": "COQ2", "protein_names_uniprotkb": "4-hydroxybenzoate polyprenyltransferase, mitochondrial; 2.5.1.39; 4-HB polyprenyltransferase; 4-hydroxybenzoate hexaprenyltransferase; PHB:PPT; PHB:polyprenyltransferase; Para-hydroxybenzoate--polyprenyltransferase", "protein_names_refseq": "4-hydroxybenzoate octaprenyltransferase", "tax_id": 559292, "disease": "coenzyme Q10 deficiency disease (Disease Ontology:DOID:0050730); primary coenzyme Q10 deficiency 1 (Disease Ontology:DOID:0070238); glucose intolerance (Disease Ontology:DOID:10603); nephrotic syndrome (Disease Ontology:DOID:1184); multiple system atrophy (Disease Ontology:DOID:4752)", "pathway": " (sce:YNR041C); (R-SCE-2142789)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16823961;17322287;1740455;18407956;24374639;24406904;33491328;9169873", "class_list": "", "function": "Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate., [UniProtKB, PubMed, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1L7;Q6B1I3", "ec_number_list": [ { "id": "1.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.2.3", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "3.4.24.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.64", "type": "external" }, { "id": "2.5.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.39", "type": "external" }, { "id": "1.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.2.4", "type": "external" } ], "go_molecular_function": "GO:0008412 4-hydroxybenzoate polyprenyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P32378-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32379-1", "uniprot_id": [ { "id": "PSA5_YEAST", "url": "https://www.uniprot.org/uniprot/P32379", "type": "external" } ], "mass": 28617.0, "length": 260, "protein_name": "Proteasome subunit alpha type-5", "gene_name": "PUP2", "organism": "Yeast", "refseq_name": "proteasome core particle subunit alpha 5", "refseq_ac": [ { "id": "NP_011769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011769", "type": "external" } ], "gene_names_uniprotkb": "PUP2; DOA5; G9155", "gene_names_refseq": "DOA5; PUP2", "protein_names_uniprotkb": "Proteasome subunit alpha type-5; Macropain subunit PUP2; Multicatalytic endopeptidase complex subunit PUP2; Proteasome component PUP2; Proteinase YSCE subunit PUP2", "protein_names_refseq": "proteasome core particle subunit alpha 5", "tax_id": 559292, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (sce:YGR253C); (R-SCE-1236974); (R-SCE-1236978); (R-SCE-5668541); (R-SCE-5689880); (R-SCE-6798695); (R-SCE-9907900); (R-SCE-9912633)", "pathway_count": 8, "publication_count": 34, "publication_id_list": "11062564;11081519;11493007;14562106;1544471;15665377;16531229;16608349;16793518;17322287;17330950;17563356;18407956;19779198;19795423;19823750;20227375;20486117;20702584;21126336;21177495;22927375;23749301;24374639;27821475;30516470;32597660;33481703;33491328;34965436;7781614;9087403;9133741;9169869", "class_list": "", "function": "The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV33", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0005634 nucleus;GO:0019773 proteasome core complex, alpha-subunit complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010499 proteasomal ubiquitin-independent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P32379-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32381-1", "uniprot_id": [ { "id": "ARP2_YEAST", "url": "https://www.uniprot.org/uniprot/P32381", "type": "external" } ], "mass": 44074.0, "length": 391, "protein_name": "Actin-related protein 2", "gene_name": "ARP2", "organism": "Yeast", "refseq_name": "actin-related protein 2", "refseq_ac": [ { "id": "NP_010255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010255", "type": "external" } ], "gene_names_uniprotkb": "ARP2; ACT2; D2778", "gene_names_refseq": "ACT2; ARP2", "protein_names_uniprotkb": "Actin-related protein 2; Actin-like protein 2; Actin-like protein ARP2", "protein_names_refseq": "actin-related protein 2", "tax_id": 559292, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); lung disease (Disease Ontology:DOID:850)", "pathway": " (sce:YDL029W); (R-SCE-2029482); (R-SCE-5663213); (R-SCE-6798695)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "11248049;14562106;1729653;18407956;19779198;22814378;24374639;33481703;33491328;9169867;9210376", "class_list": "", "function": "Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRW3", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005938 cell cortex;GO:0015629 actin cytoskeleton;GO:0005885 Arp2/3 protein complex;GO:0030479 actin cortical patch", "go_biological_process": "GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0045010 actin nucleation;GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway;GO:0051654 establishment of mitochondrion localization;GO:0000001 mitochondrion inheritance", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P32381-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32383-1", "uniprot_id": [ { "id": "PLC1_YEAST", "url": "https://www.uniprot.org/uniprot/P32383", "type": "external" } ], "mass": 100548.0, "length": 869, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1", "gene_name": "PLC1", "organism": "Yeast", "refseq_name": "phosphatidylinositol phospholipase C", "refseq_ac": [ { "id": "NP_015055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015055", "type": "external" } ], "gene_names_uniprotkb": "PLC1", "gene_names_refseq": "PLC1", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1; 3.1.4.11; PLC-1; Phosphoinositide phospholipase C; Phospholipase C-1", "protein_names_refseq": "phosphatidylinositol phospholipase C", "tax_id": 559292, "disease": "familial adenomatous polyposis (Disease Ontology:DOID:0050424); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); myelodysplastic syndrome (Disease Ontology:DOID:0050908); spermatogenic failure 17 (Disease Ontology:DOID:0070174); autoinflammation, antibody deficiency, and immune dysregulation syndrome (Disease Ontology:DOID:0070615); nonsyndromic congenital nail disorder 3 (Disease Ontology:DOID:0080081); developmental and epileptic encephalopathy 12 (Disease Ontology:DOID:0080459); familial cold autoinflammatory syndrome 3 (Disease Ontology:DOID:0090064); spondylometaphyseal dysplasia with corneal dystrophy (Disease Ontology:DOID:0112303); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); breast cancer (Disease Ontology:DOID:1612); congenital heart disease (Disease Ontology:DOID:1682); colon cancer (Disease Ontology:DOID:219); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); holoprosencephaly (Disease Ontology:DOID:4621); schizophrenia (Disease Ontology:DOID:5419); retinal disease (Disease Ontology:DOID:5679); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); retinal degeneration (Disease Ontology:DOID:8466); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); acute myocardial infarction (Disease Ontology:DOID:9408); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YPL268W); (R-SCE-114604); (R-SCE-1855204); (R-SCE-202433); (R-SCE-5607764)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "12073033;24374639;24440502;8383328;8391635;8395015;9169875", "class_list": "", "function": "The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Required for cell growth, osmoresistance and expression of GPD1., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 29, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3A2", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0000775 chromosome, centromeric region;GO:0000776 kinetochore", "go_biological_process": "GO:0009395 phospholipid catabolic process;GO:0048015 phosphatidylinositol-mediated signaling;GO:0034501 protein localization to kinetochore;GO:0032958 inositol phosphate biosynthetic process;GO:0001402 signal transduction involved in filamentous growth", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32383-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32386-1", "uniprot_id": [ { "id": "YBT1_YEAST", "url": "https://www.uniprot.org/uniprot/P32386", "type": "external" } ], "mass": 189162.0, "length": 1661, "protein_name": "ATP-dependent bile acid permease", "gene_name": "YBT1", "organism": "Yeast", "refseq_name": "bile acid-transporting ATPase YBT1", "refseq_ac": [ { "id": "NP_013052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013052", "type": "external" } ], "gene_names_uniprotkb": "YBT1; BAT1", "gene_names_refseq": "BAT1; YBT1", "protein_names_uniprotkb": "ATP-dependent bile acid permease", "protein_names_refseq": "bile acid-transporting ATPase YBT1", "tax_id": 559292, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); hypertrichotic osteochondrodysplasia Cantu type (Disease Ontology:DOID:0060569); intellectual disability and myopathy syndrome (Disease Ontology:DOID:0070600); dilated cardiomyopathy 1O (Disease Ontology:DOID:0110451); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (sce:YLL048C); (R-SCE-382556); (R-SCE-8856825)", "pathway_count": 3, "publication_count": 25, "publication_id_list": "11875433;14562106;15665377;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;21649806;22218487;22970809;23749301;24374639;32597660;33481703;33491328;34965436;8139928;9169871;9182565", "class_list": "", "function": "Vacuolar class C ABC transporter which regulates the translocation of phosphatidylcholine to the vacuole lumen, the release of lumenal calcium stores, and acts as a negative regulator of vacuole fusion. Exhibits ATP-dependent bile acid transport., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VXW0;Q07882", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity;GO:0033285 ATPase-coupled monocarboxylic acid transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0045121 membrane raft;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006816 calcium ion transport;GO:0015718 monocarboxylic acid transport", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P32386-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32389-1", "uniprot_id": [ { "id": "MET4_YEAST", "url": "https://www.uniprot.org/uniprot/P32389", "type": "external" } ], "mass": 74373.0, "length": 672, "protein_name": "Transcriptional activator of sulfur metabolism MET4", "gene_name": "MET4", "organism": "Yeast", "refseq_name": "Met4p", "refseq_ac": [ { "id": "NP_014296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014296", "type": "external" } ], "gene_names_uniprotkb": "MET4; N2177", "gene_names_refseq": "MET4", "protein_names_uniprotkb": "Transcriptional activator of sulfur metabolism MET4; Methionine-requiring protein 4", "protein_names_refseq": "Met4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL103W)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10637232;14562095;14562106;1549123;15689486;15883825;17287358;17330950;17563356;18407956;19779198;20702584;21177495;23749301;24374639;31375868;32597660;33481703;33491328;7799928;8446029;8524217;8665859;8701612;9169873;9171357;9799240", "class_list": "", "function": "Positive trans-acting factor capable of stimulating the transcription of the MET genes from the methionine biosynthetic pathway. MET4, MET28 and CBF1 are required for full induction of MET25 and MET16 gene transcription. MET4 controls as well the derepression of MET6. Required for the transcription of genes necessary for sulfur amino acid biosynthesis. Involved in the transcription activation of MET28 and MET30. Required for MET3 gene expression via assembly of the MET4-MET28-MET31 and MET4-MET28-MET32 complexes. Involved in response to cadmium and arsenic. Cadmium-activated MET4 also induces glutathione biosynthesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W176", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0089713 Cbf1-Met4-Met28 complex", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046686 response to cadmium ion", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P32389-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32419-1", "uniprot_id": [ { "id": "MDHP_YEAST", "url": "https://www.uniprot.org/uniprot/P32419", "type": "external" } ], "mass": 37186.0, "length": 343, "protein_name": "Malate dehydrogenase, peroxisomal", "gene_name": "MDH3", "organism": "Yeast", "refseq_name": "malate dehydrogenase MDH3", "refseq_ac": [ { "id": "NP_010205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010205", "type": "external" } ], "gene_names_uniprotkb": "MDH3; D2468", "gene_names_refseq": "MDH3", "protein_names_uniprotkb": "Malate dehydrogenase, peroxisomal; 1.1.1.37", "protein_names_refseq": "malate dehydrogenase MDH3", "tax_id": 559292, "disease": "developmental and epileptic encephalopathy 51 (Disease Ontology:DOID:0080433); brain ischemia (Disease Ontology:DOID:2316); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (sce:YDL078C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1447211;14562106;19684113;21177495;24374639;33491328;9169867", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRS1;Q12689", "ec_number_list": [ { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0030060 L-malate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006635 fatty acid beta-oxidation;GO:0006108 malate metabolic process;GO:0006097 glyoxylate cycle;GO:0006735 NADH regeneration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32419-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32432-1", "uniprot_id": [ { "id": "SFP1_YEAST", "url": "https://www.uniprot.org/uniprot/P32432", "type": "external" } ], "mass": 74785.0, "length": 683, "protein_name": "Transcription factor SFP1", "gene_name": "SFP1", "organism": "Yeast", "refseq_name": "zinc-coordinating transcription factor SFP1", "refseq_ac": [ { "id": "NP_013507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013507", "type": "external" } ], "gene_names_uniprotkb": "SFP1; L8084.4", "gene_names_refseq": "SFP1", "protein_names_uniprotkb": "Transcription factor SFP1; Split finger protein 1", "protein_names_refseq": "zinc-coordinating transcription factor SFP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR403W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11805042;14562095;14562106;15353587;15466158;15806610;17330950;1743508;18407956;19328065;19779198;20498075;21177495;24374639;32597660;33229814;33491328;9169871;9832520", "class_list": "", "function": "Transcription factor that regulates ribosomal protein (RP) and ribosome biogenesis (Ribi) gene expression in response to nutrients and stress. Promotes RP gene expression under optimal growth conditions. Leaves the nucleus upon environmental challenges, resulting in a down-regulation of RP gene transcription. The effect of the environmental cues on SFP1 localization is mediated through the TOR pathway. Also regulates the expression of genes involved in the G2/M transition during the mitotic cell cycle and the DNA-damage response. Required for carbon-source modulation of cell size., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 13, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ36", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008361 regulation of cell size;GO:0060963 positive regulation of ribosomal protein gene transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P32432-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32454-1", "uniprot_id": [ { "id": "APE2_YEAST", "url": "https://www.uniprot.org/uniprot/P32454", "type": "external" } ], "mass": 107755.0, "length": 952, "protein_name": "Aminopeptidase 2, mitochondrial", "gene_name": "APE2", "organism": "Yeast", "refseq_name": "metallo-aminopeptidase", "refseq_ac": [ { "id": "NP_012765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012765", "type": "external" } ], "gene_names_uniprotkb": "APE2; LAP1; YKL158W; YKL611; YKL612", "gene_names_refseq": "APE2; LAP1; YKL158W", "protein_names_uniprotkb": "Aminopeptidase 2, mitochondrial; 3.4.11.-; AP-II; Aminopeptidase II; YscII", "protein_names_refseq": "metallo-aminopeptidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL157W); (R-SCE-983168)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10734188;14562095;14562106;14576278;14597615;17322287;1765107;18407956;19779198;24374639;33229814;33481703;33491328;383482;8091859;8196765", "class_list": "", "function": "Involved in the cellular supply of leucine from externally offered leucine-containing dipeptide substrates., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VX41;P36055", "ec_number_list": [ { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.4.22.40", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.40", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0030287 cell wall-bounded periplasmic space", "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P32454-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32458-1", "uniprot_id": [ { "id": "CDC11_YEAST", "url": "https://www.uniprot.org/uniprot/P32458", "type": "external" } ], "mass": 47649.0, "length": 415, "protein_name": "Cell division control protein 11", "gene_name": "CDC11", "organism": "Yeast", "refseq_name": "septin CDC11", "refseq_ac": [ { "id": "NP_012610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012610", "type": "external" } ], "gene_names_uniprotkb": "CDC11; J1833; PSL9", "gene_names_refseq": "CDC11; PSL9", "protein_names_uniprotkb": "Cell division control protein 11", "protein_names_refseq": "septin CDC11", "tax_id": 559292, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (sce:YJR076C)", "pathway_count": 1, "publication_count": 32, "publication_id_list": "10579719;11165249;11875433;12058072;12665577;14562095;14562106;15282341;15665377;17287358;17330950;17563356;18407956;18791237;19684113;19779198;20489023;20702584;21177495;22814378;23749301;24374639;25971666;26780475;32597660;33481703;33491328;8641269;8791410;8840504;8885406;9813094", "class_list": "", "function": "Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring approximate 15 minutes before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck (PubMed:12665577). This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck (PubMed:12665577). The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many proteins bind asymmetrically to the septin collar (PubMed:12665577). The septin assembly is regulated by protein kinases GIN4 and/or CLA4. May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage (PubMed:12665577). Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation (PubMed:12665577). CDCd11 with SHS1 11 are involved in the recruitment of BNI5 and thereby ensure efficient localization at the bud neck of MYO1, the type II myosin of the actomyosin contractile ring (PubMed:25971666)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWP6", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding", "go_cellular_component": "GO:0005940 septin ring;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0005876 spindle microtubule;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0000920 septum digestion after cytokinesis;GO:0001934 positive regulation of protein phosphorylation;GO:0000281 mitotic cytokinesis;GO:0000921 septin ring assembly;GO:0000915 actomyosin contractile ring assembly", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P32458-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32462-1", "uniprot_id": [ { "id": "ERG24_YEAST", "url": "https://www.uniprot.org/uniprot/P32462", "type": "external" } ], "mass": 50615.0, "length": 438, "protein_name": "Delta(14)-sterol reductase ERG24", "gene_name": "ERG24", "organism": "Yeast", "refseq_name": "delta(14)-sterol reductase", "refseq_ac": [ { "id": "NP_014119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014119", "type": "external" } ], "gene_names_uniprotkb": "ERG24; N0593", "gene_names_refseq": "ERG24", "protein_names_uniprotkb": "Delta(14)-sterol reductase ERG24; 1.3.1.70; C-14 sterol reductase ERG24; Ergosterol biosynthetic protein 24; Sterol C14-reductase ERG24", "protein_names_refseq": "delta(14)-sterol reductase", "tax_id": 559292, "disease": "Greenberg dysplasia (Disease Ontology:DOID:0111588); primary biliary cholangitis (Disease Ontology:DOID:12236); ichthyosis vulgaris (Disease Ontology:DOID:1702); systemic lupus erythematosus (Disease Ontology:DOID:9074); Pelger-Huet anomaly (Disease Ontology:DOID:9631)", "pathway": " (sce:YNL280C); (R-SCE-2995383); (R-SCE-6807047); (R-SCE-6807062); (R-SCE-9013106)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "1418625;14562106;16847258;22814378;24374639;32679672;8125337;9169873", "class_list": "", "function": "Delta(14)-sterol reductase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:1418625, PubMed:8125337). ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol (PubMed:1418625, PubMed:8125337). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25. Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (PubMed:32679672)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0R4", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "1.3.1.70", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.70", "type": "external" } ], "go_molecular_function": "GO:0050661 NADP binding;GO:0050613 Delta14-sterol reductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006696 ergosterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P32462-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32465-1", "uniprot_id": [ { "id": "HXT1_YEAST", "url": "https://www.uniprot.org/uniprot/P32465", "type": "external" } ], "mass": 63261.0, "length": 570, "protein_name": "Low-affinity glucose transporter HXT1", "gene_name": "HXT1", "organism": "Yeast", "refseq_name": "hexose transporter HXT1", "refseq_ac": [ { "id": "NP_011962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011962", "type": "external" } ], "gene_names_uniprotkb": "HXT1; HOR4", "gene_names_refseq": "HOR4; HXT1", "protein_names_uniprotkb": "Low-affinity glucose transporter HXT1", "protein_names_refseq": "hexose transporter HXT1", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR094C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "14562106;15665377;16847258;17287358;17330950;18407956;19684113;19779198;19795423;19823750;2046678;20702584;21126336;21177495;22218487;23749301;24374639;24440502;32597660;33481703;33491328;34965436;8091229;8417358", "class_list": "", "function": "Low-affinity glucose transporter. HXT1 is as well involved in the transport of mannose., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D3DL45", "ec_number_list": [], "go_molecular_function": "GO:0005353 fructose transmembrane transporter activity;GO:0015578 mannose transmembrane transporter activity;GO:0005351 carbohydrate:proton symporter activity;GO:0055056 D-glucose transmembrane transporter activity;GO:0005354 galactose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:1904659 D-glucose transmembrane transport;GO:0008643 carbohydrate transport;GO:0015761 mannose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P32465-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32466-1", "uniprot_id": [ { "id": "HXT3_YEAST", "url": "https://www.uniprot.org/uniprot/P32466", "type": "external" } ], "mass": 62558.0, "length": 567, "protein_name": "Low-affinity glucose transporter HXT3", "gene_name": "HXT3", "organism": "Yeast", "refseq_name": "hexose transporter HXT3", "refseq_ac": [ { "id": "NP_010632", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010632", "type": "external" } ], "gene_names_uniprotkb": "HXT3; D9651.14", "gene_names_refseq": "HXT3", "protein_names_uniprotkb": "Low-affinity glucose transporter HXT3", "protein_names_refseq": "hexose transporter HXT3", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR345C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "14562106;15665377;16847258;17330950;19684113;19779198;19795423;19823750;20702584;21126336;23749301;24374639;32597660;33481703;33491328;34965436;8417358;9169867", "class_list": "", "function": "Low-affinity glucose transporter., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VSX5", "ec_number_list": [], "go_molecular_function": "GO:0005353 fructose transmembrane transporter activity;GO:0015578 mannose transmembrane transporter activity;GO:0005351 carbohydrate:proton symporter activity;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:1904659 D-glucose transmembrane transport;GO:0055085 transmembrane transport;GO:0008643 carbohydrate transport;GO:0008645 hexose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P32466-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32467-1", "uniprot_id": [ { "id": "HXT4_YEAST", "url": "https://www.uniprot.org/uniprot/P32467", "type": "external" } ], "mass": 63910.0, "length": 576, "protein_name": "Low-affinity glucose transporter HXT4", "gene_name": "HXT4", "organism": "Yeast", "refseq_name": "hexose transporter HXT4", "refseq_ac": [ { "id": "NP_011960", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011960", "type": "external" } ], "gene_names_uniprotkb": "HXT4; LGT1; RAG1", "gene_names_refseq": "HXT4; LGT1; RAG1", "protein_names_uniprotkb": "Low-affinity glucose transporter HXT4; Low-affinity glucose transporter LGT1", "protein_names_refseq": "hexose transporter HXT4", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR092C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14557538;17180689;24374639;33481703;7982576;8091229;8154188", "class_list": "", "function": "Low-affinity glucose transporter. Can also transport xylose., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D3DL44", "ec_number_list": [], "go_molecular_function": "GO:0005353 fructose transmembrane transporter activity;GO:0015578 mannose transmembrane transporter activity;GO:0005351 carbohydrate:proton symporter activity;GO:0055056 D-glucose transmembrane transporter activity;GO:0015146 pentose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0008643 carbohydrate transport;GO:0008645 hexose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32467-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32468-1", "uniprot_id": [ { "id": "CDC12_YEAST", "url": "https://www.uniprot.org/uniprot/P32468", "type": "external" } ], "mass": 46668.0, "length": 407, "protein_name": "Cell division control protein 12", "gene_name": "CDC12", "organism": "Yeast", "refseq_name": "septin CDC12", "refseq_ac": [ { "id": "NP_011975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011975", "type": "external" } ], "gene_names_uniprotkb": "CDC12; CLA10; PSL7", "gene_names_refseq": "CDC12; CLA10; PSL7", "protein_names_uniprotkb": "Cell division control protein 12; Septin", "protein_names_refseq": "septin CDC12", "tax_id": 559292, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (sce:YHR107C); (R-SCE-111457)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "12058072;12665577;14562095;14562106;15282341;17563356;18407956;18791237;22814378;23749301;24374639;32597660;33481703;33491328;7649470;8091229;8791410;9813094", "class_list": "", "function": "Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring approximate 15 minutes before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many proteins bind asymmetrically to the septin collar. The septin assembly is regulated by protein kinases GIN4 and/or CLA4. May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage. Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL57", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding", "go_cellular_component": "GO:0005940 septin ring;GO:0005737 cytoplasm;GO:0015630 microtubule cytoskeleton;GO:0031105 septin complex;GO:0032160 septin filament array", "go_biological_process": "GO:0000920 septum digestion after cytokinesis;GO:0001934 positive regulation of protein phosphorylation;GO:0000281 mitotic cytokinesis;GO:0008104 intracellular protein localization;GO:0000921 septin ring assembly", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P32468-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32472-1", "uniprot_id": [ { "id": "FKBP2_YEAST", "url": "https://www.uniprot.org/uniprot/P32472", "type": "external" } ], "mass": 14487.0, "length": 135, "protein_name": "Peptidyl-prolyl cis-trans isomerase FPR2", "gene_name": "FPR2", "organism": "Yeast", "refseq_name": "peptidylprolyl isomerase family protein FPR2", "refseq_ac": [ { "id": "NP_010807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010807", "type": "external" } ], "gene_names_uniprotkb": "FPR2; D9719.24; FKB2", "gene_names_refseq": "FKB2; FPR2", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FPR2; 13-kDa membrane-associated FK506-binding protein; 5.2.1.8; FK506-binding protein 2; FKBP proline rotamase 2; FKBP-13; FKBP-15; PPIase FPR2", "protein_names_refseq": "peptidylprolyl isomerase family protein FPR2", "tax_id": 559292, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (sce:YDR519W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1279908;1380159;14562106;17322287;24374639;33481703;9169867", "class_list": "", "function": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FKBP-13 may play a role in protein trafficking in the ER., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTE0", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0005528 FK506 binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32472-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32473-1", "uniprot_id": [ { "id": "ODPB_YEAST", "url": "https://www.uniprot.org/uniprot/P32473", "type": "external" } ], "mass": 40054.0, "length": 366, "protein_name": "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial", "gene_name": "PDB1", "organism": "Yeast", "refseq_name": "pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta", "refseq_ac": [ { "id": "NP_009780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009780", "type": "external" } ], "gene_names_uniprotkb": "PDB1; YBR1511", "gene_names_refseq": "PDB1", "protein_names_uniprotkb": "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; 1.2.4.1; PDHE1-B; Pyruvate dehydrogenase complex component E1 beta", "protein_names_refseq": "pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta", "tax_id": 559292, "disease": "pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649)", "pathway": " (sce:YBR221C); (R-SCE-9837999); (R-SCE-9861559)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "14562106;17322287;17330950;19779198;24374639;30516470;33481703;33491328;7813418;8433986", "class_list": "", "function": "The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQL7", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.4", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0006086 pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P32473-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32474-1", "uniprot_id": [ { "id": "EUG1_YEAST", "url": "https://www.uniprot.org/uniprot/P32474", "type": "external" } ], "mass": 58982.0, "length": 517, "protein_name": "Protein disulfide-isomerase EUG1", "gene_name": "EUG1", "organism": "Yeast", "refseq_name": "protein disulfide isomerase EUG1", "refseq_ac": [ { "id": "NP_010806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010806", "type": "external" } ], "gene_names_uniprotkb": "EUG1; D9719.23", "gene_names_refseq": "EUG1", "protein_names_uniprotkb": "Protein disulfide-isomerase EUG1; 5.3.4.1; Endoplasmic reticulum protein EUG1; PDI", "protein_names_refseq": "protein disulfide isomerase EUG1", "tax_id": 559292, "disease": "Cole-Carpenter syndrome (Disease Ontology:DOID:0060438); asphyxia neonatorum (Disease Ontology:DOID:11088); autoimmune hepatitis (Disease Ontology:DOID:2048); post-traumatic stress disorder (Disease Ontology:DOID:2055); liver cirrhosis (Disease Ontology:DOID:5082); pulmonary hypertension (Disease Ontology:DOID:6432); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (sce:YDR518W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11485577;1406650;16002399;17322287;19684113;24374639;9169867", "class_list": "", "function": "Probably interacts with nascent polypeptides in the endoplasmic reticulum. It is an essential gene only in the absence of PDI. Its native disulfide isomerase activity is very low., [UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6VTD9;E9P901", "ec_number_list": [], "go_molecular_function": "GO:0019153 protein-disulfide reductase (glutathione) activity;GO:0051082 unfolded protein binding;GO:0015035 protein-disulfide reductase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006457 protein folding;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32474-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32476-1", "uniprot_id": [ { "id": "ERG1_YEAST", "url": "https://www.uniprot.org/uniprot/P32476", "type": "external" } ], "mass": 55126.0, "length": 496, "protein_name": "Squalene epoxidase ERG1", "gene_name": "ERG1", "organism": "Yeast", "refseq_name": "squalene monooxygenase", "refseq_ac": [ { "id": "NP_011691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011691", "type": "external" } ], "gene_names_uniprotkb": "ERG1", "gene_names_refseq": "ERG1", "protein_names_uniprotkb": "Squalene epoxidase ERG1; 1.14.14.17; Ergosterol biosynthetic protein 1; SE; Squalene monooxygenase ERG1", "protein_names_refseq": "squalene monooxygenase", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YGR175C); (R-SCE-9969896)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "12872131;14557538;14562106;15995173;16847258;1743514;22106047;24374639;32679672;33491328;8358382;9169869;9450962", "class_list": "", "function": "Squalene epoxidase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:1743514, PubMed:8358382, PubMed:9450962). ERG1 catalyzes the epoxidation of squalene into 2,3-epoxysqualene (PubMed:1743514, PubMed:8358382, PubMed:9450962). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25. Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (PubMed:32679672)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUW0", "ec_number_list": [ { "id": "1.14.14.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.17", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0004506 squalene monooxygenase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006696 ergosterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P32476-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32478-1", "uniprot_id": [ { "id": "HS150_YEAST", "url": "https://www.uniprot.org/uniprot/P32478", "type": "external" } ], "mass": 41059.0, "length": 413, "protein_name": "Cell wall mannoprotein HSP150", "gene_name": "HSP150", "organism": "Yeast", "refseq_name": "heat shock protein HSP150", "refseq_ac": [ { "id": "NP_012376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012376", "type": "external" } ], "gene_names_uniprotkb": "HSP150; CCW7; J0558; ORE1; PIR2", "gene_names_refseq": "CCW7; HSP150; ORE1; PIR2", "protein_names_uniprotkb": "Cell wall mannoprotein HSP150; 150 kDa heat shock glycoprotein; Covalently-linked cell wall protein 7; Protein with internal repeats 2", "protein_names_refseq": "heat shock protein HSP150", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL159W)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10209754;10234784;10407261;10594829;11079560;11223941;11309124;12844361;14562106;14734023;15116342;15470095;1570286;15781460;16086015;17617218;18657192;19779198;21126336;24374639;32597660;33481703;8322511;8641269;9192695;9301021", "class_list": "", "function": "Component of the outer cell wall layer. Required for stability of the cell wall and for optimal growth. Required for resistance against several antifungal and cell wall-perturbing agents and for tolerance to heat shock., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B6RI02;B6RI03;B6RI04;D6VW28;P47000;Q03179;Q6VXX4;Q86ZT2", "ec_number_list": [], "go_molecular_function": "GO:0016887 ATP hydrolysis activity;GO:0005199 structural constituent of cell wall", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005621 cellular bud scar;GO:0009277 fungal-type cell wall", "go_biological_process": "GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P32478-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32479-1", "uniprot_id": [ { "id": "HIR1_YEAST", "url": "https://www.uniprot.org/uniprot/P32479", "type": "external" } ], "mass": 93858.0, "length": 840, "protein_name": "Protein HIR1", "gene_name": "HIR1", "organism": "Yeast", "refseq_name": "Hir1p", "refseq_ac": [ { "id": "NP_009545", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009545", "type": "external" } ], "gene_names_uniprotkb": "HIR1; YBL0318", "gene_names_refseq": "HIR1", "protein_names_uniprotkb": "Protein HIR1; Histone transcription regulator 1", "protein_names_refseq": "Hir1p", "tax_id": 559292, "disease": "chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (sce:YBL008W); (R-SCE-2559584)", "pathway_count": 2, "publication_count": 33, "publication_id_list": "10445029;11404324;11412995;11756556;11782447;11937489;12524332;12975325;1441753;14562106;15057281;16020781;16039596;16264190;16303565;16449659;17330950;17563356;18407956;19683497;19684113;19779198;23749301;24374639;32597660;33481703;33491328;7813418;8417331;9001207;9504914;9671488;9671489", "class_list": "", "function": "Component of the HIR complex, which cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPZ2", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin;GO:0000417 HIR complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P32479-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32480-1", "uniprot_id": [ { "id": "HIR2_YEAST", "url": "https://www.uniprot.org/uniprot/P32480", "type": "external" } ], "mass": 98445.0, "length": 875, "protein_name": "Protein HIR2", "gene_name": "HIR2", "organism": "Yeast", "refseq_name": "Hir2p", "refseq_ac": [ { "id": "NP_014681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014681", "type": "external" } ], "gene_names_uniprotkb": "HIR2; OR26.31", "gene_names_refseq": "HIR2; SPT1", "protein_names_uniprotkb": "Protein HIR2; Histone transcription regulator 2", "protein_names_refseq": "Hir2p", "tax_id": 559292, "disease": "chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (sce:YOR038C)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10445029;11412995;11937489;12524332;14562106;16264190;16303565;16449659;18407956;19683497;21126336;21177495;23749301;24374639;32597660;33481703;33491328;8027080;8417331;9001207;9169874;9671488;9671489", "class_list": "", "function": "Component of the HIR complex, which cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during the cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W2A5", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000785 chromatin;GO:0000417 HIR complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:0016480 negative regulation of transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P32480-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32486-1", "uniprot_id": [ { "id": "KRE6_YEAST", "url": "https://www.uniprot.org/uniprot/P32486", "type": "external" } ], "mass": 80123.0, "length": 720, "protein_name": "Beta-glucan synthesis-associated protein KRE6", "gene_name": "KRE6", "organism": "Yeast", "refseq_name": "beta-glucan synthesis-associated protein KRE6", "refseq_ac": [ { "id": "NP_015485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015485", "type": "external" } ], "gene_names_uniprotkb": "KRE6; CWH48", "gene_names_refseq": "CWH48; KRE6", "protein_names_uniprotkb": "Beta-glucan synthesis-associated protein KRE6; Killer toxin-resistance protein 6", "protein_names_refseq": "beta-glucan synthesis-associated protein KRE6", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR159W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10601196;12237851;14562106;15093776;17330950;17563356;17893149;1837148;18407956;19779198;20702584;21126336;21177495;22218487;23749301;24374639;32597660;33481703;33491328;7871892;7929594;9169875", "class_list": "", "function": "Involved in the synthesis of (1->6)- and (1->3)-beta-D-glucan polymers of the yeast cell wall in vivo. It is required for full activity of beta-glucan synthase in vitro. May be involved in the maturation and transport of cell wall proteins (CWP) to the cell wall. May act as a transglucosidase and contribute to the construction of a protein-bound glucan-structure that acts as an acceptor site for the addition of (1->6)-beta-D-glucan at the cell surface., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 30, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6W4F9;Q06472", "ec_number_list": [], "go_molecular_function": "GO:0015926 glucosidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030133 transport vesicle", "go_biological_process": "GO:0006078 (1->6)-beta-D-glucan biosynthetic process;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P32486-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32491-1", "uniprot_id": [ { "id": "MKK2_YEAST", "url": "https://www.uniprot.org/uniprot/P32491", "type": "external" } ], "mass": 56758.0, "length": 506, "protein_name": "MAP kinase kinase MKK2/SSP33", "gene_name": "MKK2", "organism": "Yeast", "refseq_name": "putative mitogen-activated protein kinase kinase MKK2", "refseq_ac": [ { "id": "NP_015185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015185", "type": "external" } ], "gene_names_uniprotkb": "MKK2; LPI6C; SSP33", "gene_names_refseq": "LPI6; MKK2; SSP33", "protein_names_uniprotkb": "MAP kinase kinase MKK2/SSP33; 2.7.12.2", "protein_names_refseq": "putative mitogen-activated protein kinase kinase MKK2", "tax_id": 559292, "disease": "RASopathy (Disease Ontology:DOID:0080690); prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YPL140C); (R-SCE-168638); (R-SCE-2559580); (R-SCE-2871796); (R-SCE-450302); (R-SCE-6811555)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "12361575;14562106;17711850;20489023;24374639;33481703;33491328;8386320;9169875", "class_list": "", "function": "Serine/threonine protein kinase involved in a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. This pathway seems to start by SMP3; then involves the kinase PKC1 that may act on the BCK1 kinase that then phosphorylates MKK1 and MKK2 which themselves phosphorylate the MPK1 kinase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3M8", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "2.7.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.68", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004708 MAP kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005934 cellular bud tip;GO:0005935 cellular bud neck;GO:0043332 mating projection tip", "go_biological_process": "GO:0007165 signal transduction;GO:0000425 pexophagy;GO:0000196 cell integrity MAPK cascade;GO:0060237 regulation of fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P32491-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32492-1", "uniprot_id": [ { "id": "MYO4_YEAST", "url": "https://www.uniprot.org/uniprot/P32492", "type": "external" } ], "mass": 169344.0, "length": 1471, "protein_name": "Myosin-4", "gene_name": "MYO4", "organism": "Yeast", "refseq_name": "myosin 4", "refseq_ac": [ { "id": "NP_009373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009373", "type": "external" } ], "gene_names_uniprotkb": "MYO4; FUN22; SHE1", "gene_names_refseq": "FUN22; MYO4; SHE1", "protein_names_uniprotkb": "Myosin-4; SWI5-dependent HO expression protein 1", "protein_names_refseq": "myosin 4", "tax_id": 559292, "disease": "microvillus inclusion disease (Disease Ontology:DOID:0060775); Griscelli syndrome type 1 (Disease Ontology:DOID:0060832); progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221); melanoma (Disease Ontology:DOID:1909); cerebrovascular disease (Disease Ontology:DOID:6713)", "pathway": " (sce:YAL029C); (R-SCE-190873); (R-SCE-9013419); (R-SCE-9013420); (R-SCE-9013425)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "10212145;10792032;11032818;11101531;12499354;14562106;15082763;15328357;18407956;20439999;23749301;24374639;33481703;33491328;7731988;8056830", "class_list": "", "function": "Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Recruited to specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease, via its interaction with SHE3., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPI9", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0015629 actin cytoskeleton;GO:0016020 membrane;GO:0031941 filamentous actin", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030050 vesicle transport along actin filament;GO:0008298 intracellular mRNA localization;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P32492-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32495-1", "uniprot_id": [ { "id": "NHP2_YEAST", "url": "https://www.uniprot.org/uniprot/P32495", "type": "external" } ], "mass": 17122.0, "length": 156, "protein_name": "H/ACA ribonucleoprotein complex subunit NHP2", "gene_name": "NHP2", "organism": "Yeast", "refseq_name": "snoRNA-binding protein NHP2", "refseq_ac": [ { "id": "NP_010073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010073", "type": "external" } ], "gene_names_uniprotkb": "NHP2; D1045", "gene_names_refseq": "NHP2", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit NHP2; H/ACA snoRNP protein NHP2; High mobility group-like nuclear protein 2", "protein_names_refseq": "snoRNA-binding protein NHP2", "tax_id": 559292, "disease": "autosomal recessive dyskeratosis congenita 2 (Disease Ontology:DOID:0070017)", "pathway": " (sce:YDL208W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11433018;12228251;12515383;14562095;15388873;2063628;21131909;21708174;23749301;24374639;32597660;33491328;9046097;9169867;9843512;9848653", "class_list": "", "function": "Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis (PubMed:9843512, PubMed:9848653). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:9843512, PubMed:9848653). Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (PubMed:9843512, PubMed:9848653). The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs (PubMed:21131909). The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA (PubMed:21131909). Essential for growth (PubMed:9843512). Directly binds H/ACA snoRNAs (PubMed:11433018)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRE6", "ec_number_list": [], "go_molecular_function": "GO:0034513 box H/ACA snoRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0031429 box H/ACA snoRNP complex;GO:0005732 sno(s)RNA-containing ribonucleoprotein complex", "go_biological_process": "GO:0006364 rRNA processing;GO:0031118 rRNA pseudouridine synthesis;GO:0031120 snRNA pseudouridine synthesis;GO:0000454 snoRNA guided rRNA pseudouridine synthesis;GO:0000493 box H/ACA snoRNP assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P32495-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32496-1", "uniprot_id": [ { "id": "RPN12_YEAST", "url": "https://www.uniprot.org/uniprot/P32496", "type": "external" } ], "mass": 31919.0, "length": 274, "protein_name": "26S proteasome regulatory subunit RPN12", "gene_name": "RPN12", "organism": "Yeast", "refseq_name": "proteasome regulatory particle lid subunit RPN12", "refseq_ac": [ { "id": "NP_116710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116710", "type": "external" } ], "gene_names_uniprotkb": "RPN12; NIN1", "gene_names_refseq": "NIN1; RPN12", "protein_names_uniprotkb": "26S proteasome regulatory subunit RPN12; Nuclear integrity protein 1", "protein_names_refseq": "proteasome regulatory particle lid subunit RPN12", "tax_id": 559292, "disease": "", "pathway": " (sce:YFR052W); (R-SCE-1236978); (R-SCE-5668541); (R-SCE-5689880); (R-SCE-9907900)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "12504901;14562106;1563492;21126336;22927375;24374639;33491328;7621825;7670463;8686379", "class_list": "", "function": "Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Necessary for activation of the CDC28 kinase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTT5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0005634 nucleus;GO:0008541 proteasome regulatory particle, lid subcomplex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P32496-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32499-1", "uniprot_id": [ { "id": "NUP2_YEAST", "url": "https://www.uniprot.org/uniprot/P32499", "type": "external" } ], "mass": 77881.0, "length": 720, "protein_name": "Nucleoporin NUP2", "gene_name": "NUP2", "organism": "Yeast", "refseq_name": "nucleoporin NUP2", "refseq_ac": [ { "id": "NP_013439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013439", "type": "external" } ], "gene_names_uniprotkb": "NUP2; L8300.9", "gene_names_refseq": "NUP2", "protein_names_uniprotkb": "Nucleoporin NUP2; Nuclear pore protein NUP2; p95", "protein_names_refseq": "nucleoporin NUP2", "tax_id": 559292, "disease": "inflammatory myofibroblastic tumor (Disease Ontology:DOID:0050905); brain disease (Disease Ontology:DOID:936); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (sce:YLR335W)", "pathway_count": 1, "publication_count": 43, "publication_id_list": "10525531;10684247;11046143;11387327;11425876;11535617;11867631;11875433;12062099;12372823;12543930;12604785;12791264;12917401;14514698;14532109;14562106;15039779;15972895;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20190278;20702584;21126336;21177495;22218487;23645671;23749301;24374639;30516470;31208443;32597660;33229814;33481703;33491328;8443417;9169871", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). As one of the FG repeat nucleoporins NUP2 is involved in interactions with and guidance of nuclear transport receptors such as SRP1-KAP95 (importin alpha and beta) through the NPC. Like the closely related NUP1 it also plays an important role in disassembling and recycling SRP1-KAP95 to the cytoplasm after nuclear import. Upon entry of the heterotrimeric SRP1-KAP95-cargo complex in the nucleus, NUP2 binds through its N-terminus to the SRP1 nuclear localization signal (NLS) binding site, thus accelerating the release of the NLS-cargo. SRP1 in turn is released from NUP2 by binding of the GSP1-GTP associated export factor CSE1. NUP2 may also have a chromatin boundary/insulator activity through indirect interaction with genomic DNA via CSE1 and blocking of heterochromatin spreading., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 16, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 16, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 16, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 84, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "D6VYX5;Q06130", "ec_number_list": [], "go_molecular_function": "GO:0061676 importin-alpha family protein binding;GO:0031267 small GTPase binding;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0031509 subtelomeric heterochromatin formation;GO:0006913 nucleocytoplasmic transport;GO:0006611 protein export from nucleus;GO:0031990 mRNA export from nucleus in response to heat stress", "synthesized_glycan_count": 0, "hit_score": 6.1, "record_id": "P32499-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32500-1", "uniprot_id": [ { "id": "NDC1_YEAST", "url": "https://www.uniprot.org/uniprot/P32500", "type": "external" } ], "mass": 74134.0, "length": 655, "protein_name": "Nucleoporin NDC1", "gene_name": "NDC1", "organism": "Yeast", "refseq_name": "Ndc1p", "refseq_ac": [ { "id": "NP_013681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013681", "type": "external" } ], "gene_names_uniprotkb": "NDC1", "gene_names_refseq": "NDC1", "protein_names_uniprotkb": "Nucleoporin NDC1; Nuclear division cycle protein 1; Nuclear pore protein NDC1", "protein_names_refseq": "Ndc1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YML031W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10684247;10688190;11283351;11352933;11935220;12791264;14562106;15075274;16436507;16847258;17563356;18407956;19779198;21126336;23749301;24374639;32597660;33481703;33491328;8349727;9169872;9864355", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC) and the spindle pole body (SPB), probably by playing a key role in de novo assembly and insertion of both structures in the nuclear envelope. In SPB duplication NDC1 is required for the insertion of the cytoplasmic side of the SPB in the nuclear envelope, thus allowing for the assembly of the nucleoplasmic SPB side. NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZE3", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore;GO:0106166 spindle pole body-nuclear membrane anchor activity", "go_cellular_component": "GO:0070762 nuclear pore transmembrane ring;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0005816 spindle pole body", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:0015031 protein transport;GO:0051028 mRNA transport;GO:0030474 spindle pole body duplication", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P32500-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32504-1", "uniprot_id": [ { "id": "CBF3A_YEAST", "url": "https://www.uniprot.org/uniprot/P32504", "type": "external" } ], "mass": 111917.0, "length": 956, "protein_name": "Centromere DNA-binding protein complex CBF3 subunit A", "gene_name": "CBF2", "organism": "Yeast", "refseq_name": "Cbf2p", "refseq_ac": [ { "id": "NP_011656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011656", "type": "external" } ], "gene_names_uniprotkb": "CBF2; CBF3A; CEP2; CTF14; NDC10", "gene_names_refseq": "CBF2; CEP2; CSL5; CTF14; NDC10", "protein_names_uniprotkb": "Centromere DNA-binding protein complex CBF3 subunit A; Centromere-binding factor 2; Chromosome transmission fidelity protein 14; Kinetochore protein CTF14", "protein_names_refseq": "Cbf2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR140W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10323865;10427094;14562106;15090617;17322287;18407956;19779198;19795423;19823750;23749301;24374639;33481703;33491328;8486732;8486733;9169869", "class_list": "", "function": "Acts as a component of the centromere DNA-binding protein complex CBF3, which is essential for chromosome segregation and movement of centromeres along microtubules. CBF3 is required for the recruitment of other kinetochore complexes to CEN DNA. It plays a role in the attachment of chromosomes to the spindle and binds selectively to a highly conserved DNA sequence called CDEIII, found in centromers and in several promoters., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VUS0;E9P954", "ec_number_list": [], "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003677 DNA binding;GO:0019237 centromeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005819 spindle;GO:0051233 spindle midzone;GO:0000776 kinetochore;GO:0000779 condensed chromosome, centromeric region", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0007059 chromosome segregation;GO:0000921 septin ring assembly;GO:0000022 mitotic spindle elongation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P32504-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32505-1", "uniprot_id": [ { "id": "NAB2_YEAST", "url": "https://www.uniprot.org/uniprot/P32505", "type": "external" } ], "mass": 58321.0, "length": 525, "protein_name": "Nuclear polyadenylated RNA-binding protein NAB2", "gene_name": "NAB2", "organism": "Yeast", "refseq_name": "mRNA-binding protein NAB2", "refseq_ac": [ { "id": "NP_011393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011393", "type": "external" } ], "gene_names_uniprotkb": "NAB2", "gene_names_refseq": "NAB2", "protein_names_uniprotkb": "Nuclear polyadenylated RNA-binding protein NAB2", "protein_names_refseq": "mRNA-binding protein NAB2", "tax_id": 559292, "disease": "autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308); autosomal recessive intellectual developmental disorder 56 (Disease Ontology:DOID:0081217); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (sce:YGL122C)", "pathway_count": 1, "publication_count": 32, "publication_id_list": "11779864;11927564;12496292;14562106;17322287;17630287;17636033;18190927;18682389;19795423;19823750;19840948;20463024;20823268;22218487;22560733;23222640;23535894;23749301;23994011;24374639;26046779;26119729;26220998;28180315;32597660;33481703;33491328;33856219;39461343;8474438;9169869", "class_list": "", "function": "RNA-binding protein involved in RNA processing and transcription regulation (PubMed:11779864, PubMed:11927564, PubMed:17630287, PubMed:17636033, PubMed:26119729, PubMed:26220998, PubMed:39461343). Acts as a regulator of mRNA stability: binds the poly(A) tail of mRNAs and pre-mRNAs, preventing their degradation by the exosome (PubMed:17636033, PubMed:26119729). Involved in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Involved in mRNA poly(A) tail length control and nuclear export (PubMed:11779864, PubMed:11927564). Functions in surveillance and the packaging leading to generation of export-competent mRNPs (PubMed:19840948, PubMed:22560733). Controls both mRNP compaction that facilitates movement through nuclear pore complexes and the length of transcript poly(A) tails (PubMed:19840948, PubMed:22560733). Also acts as a regulator of transcription (PubMed:26220998, PubMed:8474438). Associates directly with nascent RNA polymerase II transcripts and remains associated during subsequent nuclear RNA processing reactions (PubMed:8474438). Required for RNA polymerase III (RNAPIII) transcription: required for the occupancy of RNAPIII and Transcription factor IIIB (TFIIIB) at target genes, possibly via direct association with nascent RNAPIII transcripts (PubMed:26220998)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VU26", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000049 tRNA binding;GO:0008097 5S rRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0043488 regulation of mRNA stability;GO:0045945 positive regulation of transcription by RNA polymerase III;GO:1900152 negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0160091 spliceosome-depend formation of circular RNA", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P32505-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32521-1", "uniprot_id": [ { "id": "PAN1_YEAST", "url": "https://www.uniprot.org/uniprot/P32521", "type": "external" } ], "mass": 160267.0, "length": 1480, "protein_name": "Actin cytoskeleton-regulatory complex protein PAN1", "gene_name": "PAN1", "organism": "Yeast", "refseq_name": "actin cytoskeleton-regulatory complex protein PAN1", "refseq_ac": [ { "id": "NP_012271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012271", "type": "external" } ], "gene_names_uniprotkb": "PAN1; DIM2; MDP3; MIP3; YIB6C", "gene_names_refseq": "DIM2; MDP3; MIP3; PAN1", "protein_names_uniprotkb": "Actin cytoskeleton-regulatory complex protein PAN1; Mitochondrial distribution of proteins protein 3", "protein_names_refseq": "actin cytoskeleton-regulatory complex protein PAN1", "tax_id": 559292, "disease": "neurodegeneration with brain iron accumulation (Disease Ontology:DOID:0110734); nephrotic syndrome (Disease Ontology:DOID:1184)", "pathway": " (sce:YIR006C)", "pathway_count": 1, "publication_count": 48, "publication_id_list": "10594004;10954428;11739778;11875433;11957109;12529323;1339314;13679512;14622601;15522098;15665377;15711538;16030260;16171804;16183906;17151356;17303466;17330950;17563356;17898076;17978096;18407956;19684113;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22218487;22890988;23749301;24374639;31208443;32597660;33229814;33481703;33491328;7762303;8524255;8756649;8978817;9169870;9234686;9531549;9822599;9885245", "class_list": "", "function": "Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization. Required for the bipolar budding of diploid cells and the correct distribution of chitin at the cell surface., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 19, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 19, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 19, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 67, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 24, "binding_glycan_count": 0, "secondary_ac_list": "D6VVT6", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0005509 calcium ion binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0010008 endosome membrane;GO:0030479 actin cortical patch", "go_biological_process": "GO:0006897 endocytosis;GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0016197 endosomal transport;GO:0061709 reticulophagy;GO:0000147 actin cortical patch assembly", "synthesized_glycan_count": 0, "hit_score": 6.9, "record_id": "P32521-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32525-1", "uniprot_id": [ { "id": "ECM25_YEAST", "url": "https://www.uniprot.org/uniprot/P32525", "type": "external" } ], "mass": 68464.0, "length": 599, "protein_name": "Protein ECM25", "gene_name": "ECM25", "organism": "Yeast", "refseq_name": "Ecm25p", "refseq_ac": [ { "id": "NP_012334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012334", "type": "external" } ], "gene_names_uniprotkb": "ECM25; J0325", "gene_names_refseq": "ECM25", "protein_names_uniprotkb": "Protein ECM25; Extracellular matrix protein 25", "protein_names_refseq": "Ecm25p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL201W); (R-SCE-8980692); (R-SCE-9013106); (R-SCE-9013148); (R-SCE-9013149); (R-SCE-9013406); (R-SCE-9013409); (R-SCE-9013423); (R-SCE-9035034)", "pathway_count": 9, "publication_count": 21, "publication_id_list": "11875433;14562095;14562106;15665377;17322287;17563356;18407956;19684113;19779198;19795423;19823750;21177495;23749301;24374639;32597660;33481703;33491328;7754713;8341697;8641269;9335584", "class_list": "", "function": "May be involved in cell wall organization and biogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 30, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVZ2", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0042805 actinin binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0080135 regulation of cellular response to stress;GO:0071555 cell wall organization;GO:0051510 regulation of unidimensional cell growth", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P32525-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32527-1", "uniprot_id": [ { "id": "ZUO1_YEAST", "url": "https://www.uniprot.org/uniprot/P32527", "type": "external" } ], "mass": 49020.0, "length": 433, "protein_name": "Zuotin", "gene_name": "ZUO1", "organism": "Yeast", "refseq_name": "zuotin", "refseq_ac": [ { "id": "NP_011801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011801", "type": "external" } ], "gene_names_uniprotkb": "ZUO1", "gene_names_refseq": "ZUO1", "protein_names_uniprotkb": "Zuotin; DnaJ-related protein ZUO1; Heat shock protein 40 homolog ZUO1; J protein ZUO1; Ribosome-associated complex subunit ZUO1", "protein_names_refseq": "zuotin", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR285C); (R-SCE-3371453)", "pathway_count": 2, "publication_count": 28, "publication_id_list": "11054575;11274393;11875433;11929994;1396572;14562095;14562106;15456889;15908962;17287358;17322287;17330950;17563356;18407956;19684113;19779198;20702584;21126336;21177495;22218487;23749301;24374639;24909858;32597660;33481703;33491328;9090054;9169869", "class_list": "", "function": "Component of the ribosome-associated complex (RAC), a heterodimeric chaperone complex involved in regulation of accurate translation termination and in folding or maintaining nascent polypeptides in a folding-competent state. RAC stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones SSB1/SSB2 that bind to the nascent polypeptide chain. ZUO1 can act as a J-protein for SSB1/SSB2 only when associated with SSZ1., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV62", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0043022 ribosome binding;GO:0030544 Hsp70 protein binding;GO:0051880 G-quadruplex DNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005840 ribosome", "go_biological_process": "GO:0051083 'de novo' cotranslational protein folding;GO:0035556 intracellular signal transduction;GO:0000054 ribosomal subunit export from nucleus;GO:0006457 protein folding;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P32527-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32528-1", "uniprot_id": [ { "id": "DUR1_YEAST", "url": "https://www.uniprot.org/uniprot/P32528", "type": "external" } ], "mass": 201832.0, "length": 1835, "protein_name": "Urea amidolyase", "gene_name": "DUR1,2", "organism": "Yeast", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DUR1,2; YBR1448", "gene_names_refseq": "", "protein_names_uniprotkb": "Urea amidolyase", "protein_names_refseq": "", "tax_id": 559292, "disease": "3-methylcrotonyl-CoA carboxylase 1 deficiency (Disease Ontology:DOID:0080579); propionic acidemia (Disease Ontology:DOID:14701); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (sce:YBR208C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;17563356;1802034;19779198;24374639;33491328;7813418;8368014", "class_list": "", "function": "Hydrolysis of urea to ammonia and CO(2)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQK5", "ec_number_list": [ { "id": "3.5.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.54", "type": "external" }, { "id": "6.3.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.6", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004039 allophanate hydrolase activity;GO:0004847 urea carboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000256 allantoin catabolic process;GO:0043419 urea catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P32528-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32558-1", "uniprot_id": [ { "id": "SPT16_YEAST", "url": "https://www.uniprot.org/uniprot/P32558", "type": "external" } ], "mass": 118630.0, "length": 1035, "protein_name": "FACT complex subunit SPT16", "gene_name": "SPT16", "organism": "Yeast", "refseq_name": "chromatin-remodeling protein SPT16", "refseq_ac": [ { "id": "NP_011308", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011308", "type": "external" } ], "gene_names_uniprotkb": "SPT16; CDC68; SSF1", "gene_names_refseq": "CDC68; SPT16; SSF1", "protein_names_uniprotkb": "FACT complex subunit SPT16; Cell division control protein 68; Facilitates chromatin transcription complex subunit SPT16; Suppressor of Ty protein 16", "protein_names_refseq": "chromatin-remodeling protein SPT16", "tax_id": 559292, "disease": "neurodevelopmental disorder with dysmorphic facies and thin corpus callosum (Disease Ontology:DOID:0070469)", "pathway": " (sce:YGL207W); (R-SCE-674695); (R-SCE-6796648); (R-SCE-6804756)", "pathway_count": 4, "publication_count": 35, "publication_id_list": "10413469;10817755;11313475;11432837;11927560;12242279;12524332;12682017;12934008;12952948;14562106;14585989;14739930;15082784;15987999;17563356;1833637;18407956;1922073;19683497;19779198;20702584;21126336;22156209;23749301;24374639;2570735;32597660;33481703;33491328;9153757;9169869;9199353;9705338;9832518", "class_list": "", "function": "Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Transcription elongation is promoted by the repression of transcription initiation from cryptic sites. Also acts in establishing transcription initiation complexes and promotes SPT15/TBP-binding to a TATA box. Together with replication factor-A protein (RPA), FACT may play a role in nucleosome deposition during DNA replication., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTU8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0000785 chromatin;GO:0035101 FACT complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0034728 nucleosome organization;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P32558-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32566-1", "uniprot_id": [ { "id": "SMI1_YEAST", "url": "https://www.uniprot.org/uniprot/P32566", "type": "external" } ], "mass": 57079.0, "length": 505, "protein_name": "Cell wall assembly regulator SMI1", "gene_name": "SMI1", "organism": "Yeast", "refseq_name": "Smi1p", "refseq_ac": [ { "id": "NP_011745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011745", "type": "external" } ], "gene_names_uniprotkb": "SMI1; G8553; KNR4; KTR4", "gene_names_refseq": "KNR4; SMI1", "protein_names_uniprotkb": "Cell wall assembly regulator SMI1; Killer toxin-resistance protein 4", "protein_names_refseq": "Smi1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR229C)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "10206705;11410349;11875433;14562106;16362369;17287358;17322287;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;21725298;22106047;22218487;23749301;24374639;27821475;30516470;32597660;33481703;33491328;8289782;8516310;8701610;9169869", "class_list": "", "function": "Protein involved in the regulation of cell wall assembly and 1,3-beta-glucan synthesis, possibly through the transcriptional regulation of cell wall glucan and chitin synthesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV09", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000131 incipient cellular bud site;GO:0005935 cellular bud neck;GO:0043332 mating projection tip", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007346 regulation of mitotic cell cycle;GO:0032995 regulation of fungal-type cell wall biogenesis;GO:0070880 fungal-type cell wall beta-glucan biosynthetic process;GO:0071555 cell wall organization", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P32566-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32567-1", "uniprot_id": [ { "id": "PAH1_YEAST", "url": "https://www.uniprot.org/uniprot/P32567", "type": "external" } ], "mass": 95031.0, "length": 862, "protein_name": "Phosphatidic acid phosphohydrolase 1", "gene_name": "PAH1", "organism": "Yeast", "refseq_name": "phosphatidate phosphatase PAH1", "refseq_ac": [ { "id": "NP_013888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013888", "type": "external" } ], "gene_names_uniprotkb": "PAH1; PAP1; SMP2; YM8520.14C", "gene_names_refseq": "PAH1; SMP2", "protein_names_uniprotkb": "Phosphatidic acid phosphohydrolase 1; 3.1.3.4; PAP1; Protein SMP2", "protein_names_refseq": "phosphatidate phosphatase PAH1", "tax_id": 559292, "disease": "Majeed syndrome (Disease Ontology:DOID:0061224); myoglobinuria (Disease Ontology:DOID:0080108); morbid obesity (Disease Ontology:DOID:11981); lipid metabolism disorder (Disease Ontology:DOID:3146); end stage renal disease (Disease Ontology:DOID:783); lipodystrophy (Disease Ontology:DOID:811); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YMR165C); (R-SCE-1483191); (R-SCE-1483213); (R-SCE-4419969); (R-SCE-75109)", "pathway_count": 5, "publication_count": 37, "publication_id_list": "14562095;14562106;15665377;15889145;16467296;16968695;17287358;17330950;17563356;17910939;17971454;18407956;19684113;19779198;19795423;19823750;20702584;20876142;21081492;21126336;21177495;21422231;22334681;23749301;24374639;24876385;27044741;29765047;30516470;31645435;32597660;33481703;33491328;35780834;39577771;8437575;9169872", "class_list": "", "function": "Mg(2+)-dependent phosphatidate (PA) phosphatase which catalyzes the dephosphorylation of PA to yield diacylglycerol (PubMed:16467296, PubMed:16968695, PubMed:17910939, PubMed:17971454, PubMed:20876142, PubMed:21081492, PubMed:29765047, PubMed:39577771). Required for de novo lipid synthesis and formation of lipid droplets (PubMed:21422231). Controls transcription of phospholipid biosynthetic genes and nuclear structure by regulating the amount of membrane present at the nuclear envelope (PubMed:15889145). Involved in plasmid maintenance, in respiration and in cell proliferation (PubMed:8437575)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 59, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VZY7", "ec_number_list": [ { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "3.6.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75", "type": "external" } ], "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0008195 phosphatidate phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0042144 vacuole fusion, non-autophagic;GO:0006351 DNA-templated transcription;GO:0009062 fatty acid catabolic process;GO:0006651 diacylglycerol biosynthetic process;GO:0019432 triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P32567-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32568-1", "uniprot_id": [ { "id": "SNQ2_YEAST", "url": "https://www.uniprot.org/uniprot/P32568", "type": "external" } ], "mass": 168767.0, "length": 1501, "protein_name": "Protein SNQ2", "gene_name": "SNQ2", "organism": "Yeast", "refseq_name": "ATP-binding cassette transporter SNQ2", "refseq_ac": [ { "id": "NP_010294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010294", "type": "external" } ], "gene_names_uniprotkb": "SNQ2; YD8119.16", "gene_names_refseq": "SNQ2", "protein_names_uniprotkb": "Protein SNQ2", "protein_names_refseq": "ATP-binding cassette transporter SNQ2", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR011W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "14562106;17330950;17563356;18407956;19779198;20702584;21126336;22218487;22814378;23749301;24374639;32597660;33481703;33491328;7629127;8437567;8896275;9169867", "class_list": "", "function": "Could be an ATP-dependent permease. Confers hyper-resistance to the mutagens 4-nitroquinoline-N-oxide (4-NQO) and triaziquone, as well as to the chemicals sulphomethuron methyl phenanthroline when present in multiple copies. Exhibits nucleoside triphosphatase activity., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6VRZ7", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0030003 intracellular monoatomic cation homeostasis;GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P32568-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32569-1", "uniprot_id": [ { "id": "MED17_YEAST", "url": "https://www.uniprot.org/uniprot/P32569", "type": "external" } ], "mass": 78476.0, "length": 687, "protein_name": "Mediator of RNA polymerase II transcription subunit 17", "gene_name": "SRB4", "organism": "Yeast", "refseq_name": "Srb4p", "refseq_ac": [ { "id": "NP_010939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010939", "type": "external" } ], "gene_names_uniprotkb": "SRB4; MED17", "gene_names_refseq": "MED17; SRB4", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 17; Mediator complex subunit 17; Suppressor of RNA polymerase B 4", "protein_names_refseq": "Srb4p", "tax_id": 559292, "disease": "infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly (Disease Ontology:DOID:0111262)", "pathway": " (sce:YER022W)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "11555651;12191485;14562095;14562106;1508147;15175151;15477388;15665377;15710619;16002404;16076843;16263706;16429153;16630888;16885025;17192271;17322287;17563356;18407956;19779198;23749301;24374639;32597660;33491328;8187178;8324825;9169868;9660972;9671455;9845373", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLS1;Q06790;Q6B1B4", "ec_number_list": [], "go_molecular_function": "GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0003712 transcription coregulator activity;GO:0001139 RNA polymerase II complex recruiting activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat;GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P32569-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32570-1", "uniprot_id": [ { "id": "MED22_YEAST", "url": "https://www.uniprot.org/uniprot/P32570", "type": "external" } ], "mass": 13863.0, "length": 121, "protein_name": "Mediator of RNA polymerase II transcription subunit 22", "gene_name": "SRB6", "organism": "Yeast", "refseq_name": "Srb6p", "refseq_ac": [ { "id": "NP_009812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009812", "type": "external" } ], "gene_names_uniprotkb": "SRB6; MED22; YBR1721", "gene_names_refseq": "MED22; SRB6", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 22; Mediator complex subunit 22; Suppressor of RNA polymerase B 6", "protein_names_refseq": "Srb6p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR253W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "12191485;14562095;14562106;14623974;15175151;15477388;16002404;16076843;16263706;16885025;17192271;22814378;24374639;33229814;7813418;8187178;8324825;8465606;9660972;9671455", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VQP9", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P32570-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32571-1", "uniprot_id": [ { "id": "UBP4_YEAST", "url": "https://www.uniprot.org/uniprot/P32571", "type": "external" } ], "mass": 105192.0, "length": 926, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 4", "gene_name": "DOA4", "organism": "Yeast", "refseq_name": "ubiquitin-specific protease DOA4", "refseq_ac": [ { "id": "NP_010354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010354", "type": "external" } ], "gene_names_uniprotkb": "DOA4; D4270; DOS1; MUT4; NPI2; SSV7; UBP4; YD8554.02C; YD9609.23C", "gene_names_refseq": "DOA4; DOS1; MUT4; NPI2; SSV7; UBP4", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 4; 3.4.19.12; Deubiquitinating enzyme 4; Ubiquitin thioesterase 4; Ubiquitin-specific-processing protease 4; Vacuole biogenesis protein SSV7", "protein_names_refseq": "ubiquitin-specific protease DOA4", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR069C)", "pathway_count": 1, "publication_count": 35, "publication_id_list": "10069815;10194416;10207058;10436014;11029042;11294906;11325936;11416128;14523026;14562095;14562106;14990574;15086794;15326198;16641373;17130288;17145966;17376168;17446860;17513562;18407956;19410548;19779198;21126336;23749301;24374639;32597660;33491328;8247125;8657109;8789263;9119204;9169867;9312043;9447974", "class_list": "", "function": "Ubiquitin thioesterase that acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole. Also removes ubiquitin from soluble proteins targeted to proteasomes. Is essential to maintain a normal level of free ubiquitin. Involved in the ammonium-induced down-regulation of the GAP1 permease and the UME3 destruction in response to oxidative stress. Has a role in the RAD9 checkpoint response to TOP1 poisons. Required for promoting coordination of DNA replication and avoids DNA overreplication., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VS55", "ec_number_list": [], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005829 cytosol;GO:0031902 late endosome membrane;GO:0000502 proteasome complex", "go_biological_process": "GO:0010992 ubiquitin recycling;GO:0006897 endocytosis;GO:0016579 protein deubiquitination;GO:0006275 regulation of DNA replication;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P32571-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32573-1", "uniprot_id": [ { "id": "SPS19_YEAST", "url": "https://www.uniprot.org/uniprot/P32573", "type": "external" } ], "mass": 31109.0, "length": 292, "protein_name": "Peroxisomal 2,4-dienoyl-CoA reductase SPS19 [(3E)-enoyl-CoA-producing]", "gene_name": "SPS19", "organism": "Yeast", "refseq_name": "2,4-dienoyl-CoA reductase (NADPH)", "refseq_ac": [ { "id": "NP_014197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014197", "type": "external" } ], "gene_names_uniprotkb": "SPS19; N1362; SPX19", "gene_names_refseq": "SPS19; SPX19", "protein_names_uniprotkb": "Peroxisomal 2,4-dienoyl-CoA reductase SPS19 [(3E)-enoyl-CoA-producing]; 1.3.1.124; Sporulation-specific protein SPX19", "protein_names_refseq": "2,4-dienoyl-CoA reductase (NADPH)", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL202W); (R-SCE-390247); (R-SCE-9033241)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11170837;17322287;22106047;24374639;7725799;7969036;9169873;9268358;9427398", "class_list": "", "function": "Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Dispensable for growth and sporulation on solid acetate and oleate media, but is essential for these processes to occur on petroselineate., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0Y6", "ec_number_list": [ { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.4", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.56", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" } ], "go_molecular_function": "GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0009062 fatty acid catabolic process;GO:0030437 ascospore formation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P32573-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32579-1", "uniprot_id": [ { "id": "SUA5_YEAST", "url": "https://www.uniprot.org/uniprot/P32579", "type": "external" } ], "mass": 46538.0, "length": 426, "protein_name": "Threonylcarbamoyl-AMP synthase", "gene_name": "SUA5", "organism": "Yeast", "refseq_name": "threonylcarbamoyladenylate synthase", "refseq_ac": [ { "id": "NP_011346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011346", "type": "external" } ], "gene_names_uniprotkb": "SUA5; G1660", "gene_names_refseq": "SUA5", "protein_names_uniprotkb": "Threonylcarbamoyl-AMP synthase; 2.7.7.87; L-threonylcarbamoyladenylate synthase; Suppressor of upstream AUG protein 5; TC-AMP synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein SUA5; tRNA threonylcarbamoyladenosine biosynthesis protein SUA5", "protein_names_refseq": "threonylcarbamoyladenylate synthase", "tax_id": 559292, "disease": "Galloway-Mowat syndrome (Disease Ontology:DOID:0080694)", "pathway": " (sce:YGL169W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "1325384;14562095;14562106;19287007;19369944;19884342;21183954;23258706;23620299;24374639;8896267;9169869", "class_list": "", "function": "Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTY3", "ec_number_list": [ { "id": "2.7.7.87", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.87", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0003725 double-stranded RNA binding;GO:0016779 nucleotidyltransferase activity;GO:0043047 single-stranded telomeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006417 regulation of translation;GO:0000723 telomere maintenance;GO:0002949 tRNA threonylcarbamoyladenosine modification;GO:0006450 regulation of translational fidelity;GO:0070525 tRNA threonylcarbamoyladenosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P32579-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32580-1", "uniprot_id": [ { "id": "SUV3_YEAST", "url": "https://www.uniprot.org/uniprot/P32580", "type": "external" } ], "mass": 84324.0, "length": 737, "protein_name": "ATP-dependent RNA helicase SUV3, mitochondrial", "gene_name": "SUV3", "organism": "Yeast", "refseq_name": "ATP-dependent RNA helicase SUV3", "refseq_ac": [ { "id": "NP_015296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015296", "type": "external" } ], "gene_names_uniprotkb": "SUV3; LPB2W", "gene_names_refseq": "LPB2; SUV3", "protein_names_uniprotkb": "ATP-dependent RNA helicase SUV3, mitochondrial; 3.6.4.13", "protein_names_refseq": "ATP-dependent RNA helicase SUV3", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL029W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12426313;1379722;14562106;14576278;24374639;33491328;9169875", "class_list": "", "function": "Required for intron-independent turnover and processing of mitochondrial RNA. It is a key control element in nuclear-mitochondrial interactions., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W3Y4;Q02649", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045025 mitochondrial degradosome", "go_biological_process": "GO:0000957 mitochondrial RNA catabolic process;GO:0000965 mitochondrial RNA 3'-end processing;GO:0006264 mitochondrial DNA replication;GO:0000372 Group I intron splicing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32580-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32581-1", "uniprot_id": [ { "id": "IME2_YEAST", "url": "https://www.uniprot.org/uniprot/P32581", "type": "external" } ], "mass": 73593.0, "length": 645, "protein_name": "Meiosis induction protein kinase IME2/SME1", "gene_name": "IME2", "organism": "Yeast", "refseq_name": "protein kinase IME2", "refseq_ac": [ { "id": "NP_012429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012429", "type": "external" } ], "gene_names_uniprotkb": "IME2; J0817; SME1", "gene_names_refseq": "IME2; SME1", "protein_names_uniprotkb": "Meiosis induction protein kinase IME2/SME1; 2.7.11.1", "protein_names_refseq": "protein kinase IME2", "tax_id": 559292, "disease": "endocrine-cerebro-osteodysplasia syndrome (Disease Ontology:DOID:0060641); retinitis pigmentosa 62 (Disease Ontology:DOID:0110380); juvenile myoclonic epilepsy 10 (Disease Ontology:DOID:0111325)", "pathway": " (sce:YJL106W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14612412;16684773;20489023;20543984;2196430;24374639;35240051;7483851;8641269", "class_list": "", "function": "Protein kinase which is essential for the initiation of meiosis and sporulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW78", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0051321 meiotic cell cycle;GO:0040020 regulation of meiotic nuclear division;GO:0030435 sporulation resulting in formation of a cellular spore", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P32581-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32582-1", "uniprot_id": [ { "id": "CBS_YEAST", "url": "https://www.uniprot.org/uniprot/P32582", "type": "external" } ], "mass": 56022.0, "length": 507, "protein_name": "Cystathionine beta-synthase", "gene_name": "CYS4", "organism": "Yeast", "refseq_name": "cystathionine beta-synthase CYS4", "refseq_ac": [ { "id": "NP_011671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011671", "type": "external" } ], "gene_names_uniprotkb": "CYS4; G6667; STR4", "gene_names_refseq": "CYS4; NHS5; STR4; VMA41", "protein_names_uniprotkb": "Cystathionine beta-synthase; 4.2.1.22; Beta-thionase; Serine sulfhydrase; Sulfur transfer protein 4", "protein_names_refseq": "cystathionine beta-synthase CYS4", "tax_id": 559292, "disease": "vitamin B12 deficiency (Disease Ontology:DOID:0050731); neural tube defect (Disease Ontology:DOID:0080074); malaria (Disease Ontology:DOID:12365); Down syndrome (Disease Ontology:DOID:14250); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); ovarian cancer (Disease Ontology:DOID:2394); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); homocystinuria (Disease Ontology:DOID:9263); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (sce:YGR155W); (R-SCE-1614603)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "14562106;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22814378;23749301;24374639;32597660;33481703;33491328;8022826;8366024;8585325;9169869", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VUT5;Q05177;Q27JK1;Q27JK4", "ec_number_list": [ { "id": "4.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.22", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0004122 cystathionine beta-synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0007089 traversing start control point of mitotic cell cycle;GO:0019346 transsulfuration;GO:0006535 cysteine biosynthetic process from serine;GO:0019343 cysteine biosynthetic process via cystathionine;GO:0070814 hydrogen sulfide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P32582-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32584-1", "uniprot_id": [ { "id": "STE14_YEAST", "url": "https://www.uniprot.org/uniprot/P32584", "type": "external" } ], "mass": 27888.0, "length": 239, "protein_name": "Protein-S-isoprenylcysteine O-methyltransferase", "gene_name": "STE14", "organism": "Yeast", "refseq_name": "protein-S-isoprenylcysteine carboxyl O-methyltransferase", "refseq_ac": [ { "id": "NP_010698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010698", "type": "external" } ], "gene_names_uniprotkb": "STE14; D9461.1", "gene_names_refseq": "STE14", "protein_names_uniprotkb": "Protein-S-isoprenylcysteine O-methyltransferase; 2.1.1.100; ICMT; Isoprenylcysteine carboxylmethyltransferase; PPMT; Prenylated protein carboxyl methyltransferase; Prenylcysteine carboxyl methyltransferase; pcCMT", "protein_names_refseq": "protein-S-isoprenylcysteine carboxyl O-methyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR410C); (R-SCE-163841)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11451995;14562095;14562106;15611058;16847258;18923140;2050108;24374639;8212897;8289819;9169867;9693378", "class_list": "", "function": "Mediates C-terminal methylation of the isoprenylated C-terminal cysteine in A-factor mating pheromone and Ras proteins (PubMed:11451995, PubMed:15611058, PubMed:8289819). Does not have a preference for the farnesyl or geranylgeranyl moieties in the model substrates N-acetyl-S-farnesyl-L-cysteine (AFC) and N-acetyl-S-geranylgeranyl-L-cysteine (AGGC) in vitro (PubMed:15611058)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT42", "ec_number_list": [ { "id": "2.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.100", "type": "external" } ], "go_molecular_function": "GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0006481 C-terminal protein methylation;GO:0007323 peptide pheromone maturation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P32584-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32585-1", "uniprot_id": [ { "id": "MED18_YEAST", "url": "https://www.uniprot.org/uniprot/P32585", "type": "external" } ], "mass": 34289.0, "length": 307, "protein_name": "Mediator of RNA polymerase II transcription subunit 18", "gene_name": "SRB5", "organism": "Yeast", "refseq_name": "Srb5p", "refseq_ac": [ { "id": "NP_011618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011618", "type": "external" } ], "gene_names_uniprotkb": "SRB5; MED18", "gene_names_refseq": "MED18; SRB5", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 18; Mediator complex subunit 18; Suppressor of RNA polymerase B 5", "protein_names_refseq": "Srb5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR104C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "11555651;12191485;14562095;14562106;15175151;15477388;16002404;16076843;16109375;16263706;16885025;16964259;17192271;17322287;24374639;33491328;8187178;8324825;9169869;9660972;9845373", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUN6;Q6B1R3", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat;GO:0001113 transcription open complex formation at RNA polymerase II promoter;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P32585-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32588-1", "uniprot_id": [ { "id": "PUB1_YEAST", "url": "https://www.uniprot.org/uniprot/P32588", "type": "external" } ], "mass": 50763.0, "length": 453, "protein_name": "Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1", "gene_name": "PUB1", "organism": "Yeast", "refseq_name": "Pub1p", "refseq_ac": [ { "id": "NP_014382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014382", "type": "external" } ], "gene_names_uniprotkb": "PUB1; N2842; RNP1", "gene_names_refseq": "PUB1; RNP1", "protein_names_uniprotkb": "Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1; ARS consensus-binding protein ACBP-60; Poly uridylate-binding protein; Poly(U)-binding protein", "protein_names_refseq": "Pub1p", "tax_id": 559292, "disease": "amyotrophic lateral sclerosis type 26 (Disease Ontology:DOID:0081380); transient cerebral ischemia (Disease Ontology:DOID:224); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (sce:YNL016W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562106;17636033;21931728;23222640;24374639;33856219;8127652;8341595;8413212;8413213;9169873;9298649", "class_list": "", "function": "May be associated with hnRNA within the nucleus and remains associated during nucleocytoplasmic mRNA transport, once the proteins are in the cytoplasm, disassembly of PUB1-RNA complexes may occur prior to PAB1 binding and formation of a translationally competent RNP complex. Binds to polyadenylated RNA; prefers to bind poly(rU); binds to T-rich single-stranded DNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1G2", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0043022 ribosome binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006415 translational termination;GO:0043488 regulation of mRNA stability;GO:0042149 cellular response to glucose starvation;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0034063 stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P32588-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32599-1", "uniprot_id": [ { "id": "FIMB_YEAST", "url": "https://www.uniprot.org/uniprot/P32599", "type": "external" } ], "mass": 71773.0, "length": 642, "protein_name": "Fimbrin", "gene_name": "SAC6", "organism": "Yeast", "refseq_name": "fimbrin", "refseq_ac": [ { "id": "NP_010414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010414", "type": "external" } ], "gene_names_uniprotkb": "SAC6; YD9302.04C", "gene_names_refseq": "ABP67; SAC6", "protein_names_uniprotkb": "Fimbrin; ABP67", "protein_names_refseq": "fimbrin", "tax_id": 559292, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); autosomal dominant nonsyndromic deafness 76 (Disease Ontology:DOID:0112167); osteoporosis (Disease Ontology:DOID:11476); Huntington's disease (Disease Ontology:DOID:12858); congenital diaphragmatic hernia (Disease Ontology:DOID:3827)", "pathway": " (sce:YDR129C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562106;17563356;18407956;1956405;19779198;22814378;23749301;24374639;27068241;32597660;33481703;33491328;9169867", "class_list": "", "function": "Binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSB5", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0046872 metal ion binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0032432 actin filament bundle;GO:0030479 actin cortical patch", "go_biological_process": "GO:0007015 actin filament organization;GO:0051017 actin filament bundle assembly;GO:0051639 actin filament network formation;GO:0070649 formin-nucleated actin cable assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P32599-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32602-1", "uniprot_id": [ { "id": "SEC17_YEAST", "url": "https://www.uniprot.org/uniprot/P32602", "type": "external" } ], "mass": 32803.0, "length": 292, "protein_name": "Alpha-soluble NSF attachment protein", "gene_name": "SEC17", "organism": "Yeast", "refseq_name": "alpha-soluble NSF attachment protein SEC17", "refseq_ac": [ { "id": "NP_009503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009503", "type": "external" } ], "gene_names_uniprotkb": "SEC17; YBL0505; YBL0517", "gene_names_refseq": "RNS3; SEC17", "protein_names_uniprotkb": "Alpha-soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachment protein alpha; SNAP-alpha; Vesicular-fusion protein SEC17; alpha-SNAP chaperone", "protein_names_refseq": "alpha-soluble NSF attachment protein SEC17", "tax_id": 559292, "disease": "developmental and epileptic encephalopathy 107 (Disease Ontology:DOID:0070393); Alzheimer's disease (Disease Ontology:DOID:10652); Down syndrome (Disease Ontology:DOID:14250); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (sce:YBL050W); (R-SCE-204005); (R-SCE-6807878); (R-SCE-6811434); (R-SCE-6811438); (R-SCE-6811440)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10445030;15889152;1601878;18407956;22106047;22814378;24374639;33481703;33491328;7813418;8154187;8620540;8670830;9144293", "class_list": "", "function": "SNARE complex protein that binds to cis-SNARE complexes on membranes and is required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus and for homotypic vacuole fusion. During the priming step of membrane fusion, is released from cis-SNARE complexes by SEC18 to establish a pool of unpaired SNAREs, which are required for interactions in trans during docking and fusion steps. Can displace HOPS from SNARE complexes, which may be a prerequisite for trans-SNARE complex disassembly and subsequent rounds of priming, docking and fusion., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPU9", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0001671 ATPase activator activity;GO:0005483 soluble NSF attachment protein activity", "go_cellular_component": "GO:0005829 cytosol;GO:0031201 SNARE complex;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0035494 SNARE complex disassembly;GO:0042144 vacuole fusion, non-autophagic;GO:0006886 intracellular protein transport;GO:0006914 autophagy;GO:0048280 vesicle fusion with Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P32602-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32603-1", "uniprot_id": [ { "id": "SPR1_YEAST", "url": "https://www.uniprot.org/uniprot/P32603", "type": "external" } ], "mass": 51809.0, "length": 445, "protein_name": "Sporulation-specific glucan 1,3-beta-glucosidase", "gene_name": "SPR1", "organism": "Yeast", "refseq_name": "glucan 1,3-beta-glucosidase", "refseq_ac": [ { "id": "NP_014833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014833", "type": "external" } ], "gene_names_uniprotkb": "SPR1; SSG1", "gene_names_refseq": "SPR1; SSG1", "protein_names_uniprotkb": "Sporulation-specific glucan 1,3-beta-glucosidase; 3.2.1.58; Exo-1,3-beta-glucanase", "protein_names_refseq": "glucan 1,3-beta-glucosidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR190W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17322287;24374639;8419289;8509335;9169874", "class_list": "", "function": "Probably involved in the processes of spore formation and contributes to ascospore thermoresistance by participating in the morphogenesis of ascospore walls. The enzyme may do this by modifying glucan linkages in the developing ascospore wall, thus strengthening it or lending it plasticity., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W2P6", "ec_number_list": [], "go_molecular_function": "GO:0004338 glucan exo-1,3-beta-glucosidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0000324 fungal-type vacuole;GO:0005619 ascospore wall;GO:0005628 prospore membrane;GO:0009277 fungal-type cell wall", "go_biological_process": "GO:0009251 glucan catabolic process;GO:0030437 ascospore formation;GO:0071555 cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P32603-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32604-1", "uniprot_id": [ { "id": "F26_YEAST", "url": "https://www.uniprot.org/uniprot/P32604", "type": "external" } ], "mass": 52595.0, "length": 452, "protein_name": "Fructose-2,6-bisphosphatase", "gene_name": "FBP26", "organism": "Yeast", "refseq_name": "fructose-2,6-bisphosphatase", "refseq_ac": [ { "id": "NP_012380", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012380", "type": "external" } ], "gene_names_uniprotkb": "FBP26; J0575", "gene_names_refseq": "FBP26", "protein_names_uniprotkb": "Fructose-2,6-bisphosphatase; 3.1.3.46; FBPase 2", "protein_names_refseq": "fructose-2,6-bisphosphatase", "tax_id": 559292, "disease": "hyperinsulinism (Disease Ontology:DOID:2018); extrinsic cardiomyopathy (Disease Ontology:DOID:3978)", "pathway": " (sce:YJL155C); (R-SCE-9634600)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "1322693;14562106;17330950;17563356;18407956;19779198;19795423;19823750;21126336;23749301;24374639;2825652;2831055;32597660;33481703;33491328;8641269", "class_list": "", "function": "Monofunctional, high-specificity fructose-2,6-bisphosphatase, which releases phosphate from the 2-position of fructose 2,6-bisphosphate. Has no detectable 6-phosphofructo-2-kinase activity., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW32", "ec_number_list": [ { "id": "3.1.3.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.46", "type": "external" }, { "id": "2.7.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.105", "type": "external" } ], "go_molecular_function": "GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524 ATP binding;GO:0003873 6-phosphofructo-2-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0006000 fructose metabolic process;GO:0006003 fructose 2,6-bisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P32604-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32605-1", "uniprot_id": [ { "id": "RU1A_YEAST", "url": "https://www.uniprot.org/uniprot/P32605", "type": "external" } ], "mass": 34378.0, "length": 298, "protein_name": "U1 small nuclear ribonucleoprotein A", "gene_name": "MUD1", "organism": "Yeast", "refseq_name": "Mud1p", "refseq_ac": [ { "id": "NP_009677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009677", "type": "external" } ], "gene_names_uniprotkb": "MUD1; YBR0915", "gene_names_refseq": "MUD1", "protein_names_uniprotkb": "U1 small nuclear ribonucleoprotein A; Mutant U1 die protein 1; U1 snRNP A; U1-A; U1A", "protein_names_refseq": "Mud1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR119W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11804584;14562095;14562106;24374639;33481703;7813418;7900426;8449403;8849781;9012791", "class_list": "", "function": "Involved in nuclear mRNA splicing. The principal role of the U1A is to help fold or maintain U1 RNA in an active configuration. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQB7", "ec_number_list": [], "go_molecular_function": "GO:0030619 U1 snRNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P32605-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32607-1", "uniprot_id": [ { "id": "RTG1_YEAST", "url": "https://www.uniprot.org/uniprot/P32607", "type": "external" } ], "mass": 19016.0, "length": 177, "protein_name": "Retrograde regulation protein 1", "gene_name": "RTG1", "organism": "Yeast", "refseq_name": "Rtg1p", "refseq_ac": [ { "id": "NP_014574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014574", "type": "external" } ], "gene_names_uniprotkb": "RTG1", "gene_names_refseq": "RTG1", "protein_names_uniprotkb": "Retrograde regulation protein 1", "protein_names_refseq": "Rtg1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL067C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14562106;17322287;18407956;19779198;19823750;21126336;22218487;22956768;23749301;24374639;30516470;33481703;33491328;8422683;9169874;9178509", "class_list": "", "function": "Required for a novel path of interorganelle communication between mitochondria, peroxisomes and the nucleus, thereby maintaining a functional metabolic interaction between the tricarboxylic acid and glyoxylate cycles. Transcription factor that regulates CIT2 gene expression. Binds to two identical sites oriented as inverted repeats 28 bp apart in a regulatory upstream activation sequence element (UASR) in the CIT2 promoter. The core binding site is 5'-GGTCAC-3'., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W200;Q08228", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0071400 cellular response to oleic acid;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016559 peroxisome fission;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P32607-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32608-1", "uniprot_id": [ { "id": "RTG2_YEAST", "url": "https://www.uniprot.org/uniprot/P32608", "type": "external" } ], "mass": 65572.0, "length": 588, "protein_name": "Retrograde regulation protein 2", "gene_name": "RTG2", "organism": "Yeast", "refseq_name": "Rtg2p", "refseq_ac": [ { "id": "NP_011262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011262", "type": "external" } ], "gene_names_uniprotkb": "RTG2; NRF588", "gene_names_refseq": "RTG2", "protein_names_uniprotkb": "Retrograde regulation protein 2", "protein_names_refseq": "Rtg2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL252C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562106;17322287;18407956;21126336;24374639;33481703;33491328;8422683;8972578;9169869", "class_list": "", "function": "Required for a novel path of interorganelle communication between mitochondria, peroxisomes and the nucleus, thereby maintaining a functional metabolic interaction between the tricarboxylic acid and glyoxylate cycles. In particular, required for the retrograde expression of the peroxisomal isoform of citrate synthase, CIT2., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV83", "ec_number_list": [], "go_molecular_function": "GO:0051219 phosphoprotein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000791 euchromatin", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034504 protein localization to nucleus;GO:0031930 mitochondria-nucleus signaling pathway;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P32608-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32609-1", "uniprot_id": [ { "id": "PEP7_YEAST", "url": "https://www.uniprot.org/uniprot/P32609", "type": "external" } ], "mass": 59443.0, "length": 515, "protein_name": "Vacuolar segregation protein PEP7", "gene_name": "PEP7", "organism": "Yeast", "refseq_name": "phosphatidylinositol-3-phosphate binding protein", "refseq_ac": [ { "id": "NP_010610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010610", "type": "external" } ], "gene_names_uniprotkb": "PEP7; VAC1; VPL21; VPS19; VPT19", "gene_names_refseq": "PEP7; VAC1; VPL21; VPS19; VPT19", "protein_names_uniprotkb": "Vacuolar segregation protein PEP7; Carboxypeptidase Y-deficient protein 7; Protein VAC1; Vacuolar protein sorting-associated protein 19; Vacuolar protein-targeting protein 19", "protein_names_refseq": "phosphatidylinositol-3-phosphate binding protein", "tax_id": 559292, "disease": "Kariminejad neurodevelopmental syndrome (Disease Ontology:DOID:0061158)", "pathway": " (sce:YDR323C); (R-SCE-983231)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10359603;10978279;14562106;1730622;24374639;9168472;9169867", "class_list": "", "function": "Required for vacuole segregation and vacuole protein sorting. Possibly part of a complex which tethers the vacuole membrane to microtubules, either directly or via kinesin or dynein-like motor proteins. Probably functions in several interorganelle traffic pathways., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSV6;Q99229", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005774 vacuolar membrane;GO:0010009 cytoplasmic side of endosome membrane", "go_biological_process": "GO:0006895 Golgi to endosome transport;GO:0000011 vacuole inheritance;GO:0006906 vesicle fusion;GO:0006904 vesicle docking involved in exocytosis;GO:0006896 Golgi to vacuole transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32609-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32610-1", "uniprot_id": [ { "id": "VATD_YEAST", "url": "https://www.uniprot.org/uniprot/P32610", "type": "external" } ], "mass": 29194.0, "length": 256, "protein_name": "V-type proton ATPase subunit D", "gene_name": "VMA8", "organism": "Yeast", "refseq_name": "H(+)-transporting V1 sector ATPase subunit D", "refseq_ac": [ { "id": "NP_010863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010863", "type": "external" } ], "gene_names_uniprotkb": "VMA8; SYGP-ORF11", "gene_names_refseq": "VMA8", "protein_names_uniprotkb": "V-type proton ATPase subunit D; V-ATPase subunit D; Vacuolar proton pump subunit D", "protein_names_refseq": "H(+)-transporting V1 sector ATPase subunit D", "tax_id": 559292, "disease": "", "pathway": " (sce:YEL051W); (R-SCE-1222556); (R-SCE-6798695); (R-SCE-77387); (R-SCE-917977); (R-SCE-9639288)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "11283612;14562106;24374639;25971514;27295975;33491328;7797485;7831318;9169868", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:7797485, PubMed:7831318). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:7797485, PubMed:7831318)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLJ9", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0045121 membrane raft;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0048388 endosomal lumen acidification;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport;GO:0061795 Golgi lumen acidification", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P32610-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32614-1", "uniprot_id": [ { "id": "FRDS_YEAST", "url": "https://www.uniprot.org/uniprot/P32614", "type": "external" } ], "mass": 50844.0, "length": 470, "protein_name": "Fumarate reductase 1", "gene_name": "FRD1", "organism": "Yeast", "refseq_name": "fumarate reductase", "refseq_ac": [ { "id": "NP_010867", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010867", "type": "external" } ], "gene_names_uniprotkb": "FRD1; FRDS1; FRDS; SYGP-ORF35", "gene_names_refseq": "FRD1", "protein_names_uniprotkb": "Fumarate reductase 1; 1.3.1.6; FAD-dependent oxidoreductase; FRDS1; NADH-dependent fumarate reductase; Soluble fumarate reductase, cytoplasmic isozyme", "protein_names_refseq": "fumarate reductase", "tax_id": 559292, "disease": "", "pathway": " (sce:YEL047C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12949191;14562106;17330950;17345583;19779198;24374639;32597660;33481703;33491328;8946166;9169868;9587404;9711846", "class_list": "", "function": "Irreversibly catalyzes the reduction of fumarate to succinate. Together with the second isozyme of soluble fumarate reductase (OSM1), essential for anaerobic growth. Involved in maintaining redox balance. Reduction of fumarate is the main source of succinate during fermentation, and under anaerobic conditions, the formation of succinate is strictly required for the reoxidation of FADH(2)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLK3", "ec_number_list": [ { "id": "1.3.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.6", "type": "external" } ], "go_molecular_function": "GO:0010181 FMN binding;GO:0016156 fumarate reductase (NADH) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0071454 cellular response to anoxia", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P32614-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32621-1", "uniprot_id": [ { "id": "GDA1_YEAST", "url": "https://www.uniprot.org/uniprot/P32621", "type": "external" } ], "mass": 56822.0, "length": 518, "protein_name": "Guanosine-diphosphatase", "gene_name": "GDA1", "organism": "Yeast", "refseq_name": "guanosine diphosphatase", "refseq_ac": [ { "id": "NP_010872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010872", "type": "external" } ], "gene_names_uniprotkb": "GDA1; SYGP-ORF16", "gene_names_refseq": "GDA1", "protein_names_uniprotkb": "Guanosine-diphosphatase; 3.6.1.42; GDPase", "protein_names_refseq": "guanosine diphosphatase", "tax_id": 559292, "disease": "", "pathway": " (sce:YEL042W); (R-SCE-8850843)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14562106;17322287;21126336;24374639;7540172;8391537;9169868", "class_list": "", "function": "After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D3DLK7", "ec_number_list": [ { "id": "3.6.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42", "type": "external" } ], "go_molecular_function": "GO:0004382 GDP phosphatase activity;GO:0045134 UDP phosphatase activity;GO:0017111 ribonucleoside triphosphate phosphatase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006487 protein N-linked glycosylation;GO:0009134 nucleoside diphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32621-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32623-1", "uniprot_id": [ { "id": "CRH2_YEAST", "url": "https://www.uniprot.org/uniprot/P32623", "type": "external" } ], "mass": 49906.0, "length": 467, "protein_name": "Congo red hypersensitive protein 2", "gene_name": "UTR2", "organism": "Yeast", "refseq_name": "chitin transglycosylase UTR2", "refseq_ac": [ { "id": "NP_010874", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010874", "type": "external" } ], "gene_names_uniprotkb": "UTR2; CHR2; SYGP-ORF18", "gene_names_refseq": "CRH2; UTR2", "protein_names_uniprotkb": "Congo red hypersensitive protein 2; Unidentified transcript protein 2", "protein_names_refseq": "chitin transglycosylase UTR2", "tax_id": 559292, "disease": "", "pathway": " (sce:YEL040W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10757808;12045225;15781460;17302808;17322287;18694928;19734368;23919454;24374639;33481703;33491328;8411151;9169868;9613572", "class_list": "glycogene;glycosylhydrolase", "function": "Dual chitinase/transglycosylase that plays a role in cell wall architecture (PubMed:18694928, PubMed:19734368, PubMed:23919454). Chitinase and transglycosylase activities are coupled (By similarity). Required for the polysaccharide cross-linking at the septa and the cell wall (PubMed:18694928, PubMed:19734368, PubMed:23919454). More specifically, transfers chitin to both beta(1-3)- and beta(1-6)glucan in the cell wall (PubMed:18694928, PubMed:19734368, PubMed:23919454). The minimal number of intact hexopyranose units required in the molecule of the acceptor oligosaccharide is two and the effectivity of the acceptor increased with the increasing length of its oligosaccharide chain (PubMed:23919454)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "D3DLK9;Q6B1R6", "ec_number_list": [], "go_molecular_function": "GO:0016757 glycosyltransferase activity;GO:0008843 endochitinase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0000144 cellular bud neck septin ring;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006030 chitin metabolic process;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P32623-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000010001.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32626-1", "uniprot_id": [ { "id": "ENOPH_YEAST", "url": "https://www.uniprot.org/uniprot/P32626", "type": "external" } ], "mass": 25187.0, "length": 227, "protein_name": "Enolase-phosphatase E1", "gene_name": "UTR4", "organism": "Yeast", "refseq_name": "putative acireductone synthase UTR4", "refseq_ac": [ { "id": "NP_010876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010876", "type": "external" } ], "gene_names_uniprotkb": "UTR4; SYGP-ORF20", "gene_names_refseq": "UTR4", "protein_names_uniprotkb": "Enolase-phosphatase E1; 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; 3.1.3.77; Unknown transcript 4 protein", "protein_names_refseq": "putative acireductone synthase UTR4", "tax_id": 559292, "disease": "", "pathway": " (sce:YEL038W); (R-SCE-1237112)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12748633;14562095;14562106;24374639;33491328;8411151;9169868", "class_list": "", "function": "Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLL1", "ec_number_list": [ { "id": "3.1.3.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.77", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0043874 acireductone synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0019509 L-methionine salvage from methylthioadenosine", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32626-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32629-1", "uniprot_id": [ { "id": "ANP1_YEAST", "url": "https://www.uniprot.org/uniprot/P32629", "type": "external" } ], "mass": 58182.0, "length": 500, "protein_name": "Mannan polymerase II complex ANP1 subunit", "gene_name": "ANP1", "organism": "Yeast", "refseq_name": "Anp1p", "refseq_ac": [ { "id": "NP_010878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010878", "type": "external" } ], "gene_names_uniprotkb": "ANP1; GEM3; SYGP-ORF28", "gene_names_refseq": "ANP1; GEM3; MNN8", "protein_names_uniprotkb": "Mannan polymerase II complex ANP1 subunit; Aminonitrophenyl propanediol resistance protein; M-Pol II subunit ANP1", "protein_names_refseq": "Anp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YEL036C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10713261;11095735;24374639;7957057;8411151;9169868;9430634;9434768", "class_list": "glycogene;glycosyltransferase", "function": "Involved in the organization of the secretory pathway. Required to maintain a functional Golgi apparatus., [UniProtKB]; The M-Pol II complex possesses alpha-1,6-mannosyltransferase activity and is probably involved in the elongation of the mannan backbone of N-linked glycans on cell wall and periplasmic proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLL3", "ec_number_list": [], "go_molecular_function": "GO:0000009 alpha-1,6-mannosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0000137 Golgi cis cisterna;GO:0000136 mannan polymerase complex", "go_biological_process": "GO:0000032 cell wall mannoprotein biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P32629-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32639-1", "uniprot_id": [ { "id": "BRR2_YEAST", "url": "https://www.uniprot.org/uniprot/P32639", "type": "external" } ], "mass": 246185.0, "length": 2163, "protein_name": "Pre-mRNA-splicing helicase BRR2", "gene_name": "BRR2", "organism": "Yeast", "refseq_name": "ATP-dependent RNA helicase BRR2", "refseq_ac": [ { "id": "NP_011099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011099", "type": "external" } ], "gene_names_uniprotkb": "BRR2; RSS1; SNU246; SYGP-ORF66", "gene_names_refseq": "BRR2; PRP44; RSS1; SLT22; SNU246", "protein_names_uniprotkb": "Pre-mRNA-splicing helicase BRR2; 3.6.4.13; Protein Snu246", "protein_names_refseq": "ATP-dependent RNA helicase BRR2", "tax_id": 559292, "disease": "retinitis pigmentosa 33 (Disease Ontology:DOID:0110366); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (sce:YER172C)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10449419;11884590;14562106;14690591;17563356;18407956;18953335;19098916;19525970;19716790;19779198;19795423;19823750;20702584;21126336;23124065;23749301;24374639;32597660;33481703;33491328;33502312;8670905;8722763;9169868", "class_list": "", "function": "RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM80", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005681 spliceosomal complex;GO:0005682 U5 snRNP;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P32639-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32641-1", "uniprot_id": [ { "id": "RAD24_YEAST", "url": "https://www.uniprot.org/uniprot/P32641", "type": "external" } ], "mass": 75727.0, "length": 659, "protein_name": "Checkpoint protein RAD24", "gene_name": "RAD24", "organism": "Yeast", "refseq_name": "Rad24p", "refseq_ac": [ { "id": "NP_011100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011100", "type": "external" } ], "gene_names_uniprotkb": "RAD24; SYGP-ORF60", "gene_names_refseq": "RAD24", "protein_names_uniprotkb": "Checkpoint protein RAD24", "protein_names_refseq": "Rad24p", "tax_id": 559292, "disease": "", "pathway": " (sce:YER173W); (R-SCE-176187)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10660302;10913172;11486023;12604797;12665596;14562106;15964801;17330950;18407956;19779198;22814378;24374639;25719602;33481703;33491328;9169868", "class_list": "", "function": "Participates in checkpoint pathways arrest of the cell cycle, a mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. Regulates the DNA damage checkpoint pathway throughout the cell cycle, when associated with RCF5. Component of the RFC-like RAD24-RFC complex which loads the checkpoint clamp DDC1:MEC3:RAD17 complex and is involved in DNA repair pathways. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM81", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003689 DNA clamp loader activity;GO:0140463 chromatin-protein adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0035861 site of double-strand break;GO:0031389 Rad17 RFC-like complex;GO:0140445 chromosome, telomeric repeat region", "go_biological_process": "GO:0006281 DNA repair;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:0000077 DNA damage checkpoint signaling;GO:0006289 nucleotide-excision repair;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P32641-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32643-1", "uniprot_id": [ { "id": "TMT1_YEAST", "url": "https://www.uniprot.org/uniprot/P32643", "type": "external" } ], "mass": 34768.0, "length": 299, "protein_name": "Trans-aconitate 3-methyltransferase", "gene_name": "TMT1", "organism": "Yeast", "refseq_name": "trans-aconitate 3-methyltransferase", "refseq_ac": [ { "id": "NP_011102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011102", "type": "external" } ], "gene_names_uniprotkb": "TMT1; SYGP-ORF63; TAM1", "gene_names_refseq": "TAM1; TMT1", "protein_names_uniprotkb": "Trans-aconitate 3-methyltransferase; 2.1.1.145", "protein_names_refseq": "trans-aconitate 3-methyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YER175C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11695919;14562095;14562106;15147181;18092814;18407956;22814378;23749301;24374639;30516470;33491328;34965436;9169868", "class_list": "", "function": "Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate and 3-isopropylmalate at high affinity and of other molecules like cis-aconitate, isocitrate, and citrate at lower velocities and affinities. The function of trans-aconitate methylation appears to be in reducing the toxicity of this spontaneous breakdown product of cis-aconitate. The role of 3-isopropylmalate methylation is unclear but may represent a metabolic branch at 3-isopropylmalate, where some of the material is taken in the pathway leading to leucine and some is taken in a pathway to the 3-isopropylmalate methyl ester, a molecule that provides a signal to switch from vegetative to invasive growth in response to amino acid starvation., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM83", "ec_number_list": [ { "id": "2.1.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.145", "type": "external" } ], "go_molecular_function": "GO:0046547 trans-aconitate 3-methyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0032259 methylation;GO:0034198 cellular response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P32643-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32657-1", "uniprot_id": [ { "id": "CHD1_YEAST", "url": "https://www.uniprot.org/uniprot/P32657", "type": "external" } ], "mass": 168241.0, "length": 1468, "protein_name": "ATP-dependent chromatin remodeler CHD1", "gene_name": "CHD1", "organism": "Yeast", "refseq_name": "chromatin-remodeling ATPase CHD1", "refseq_ac": [ { "id": "NP_011091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011091", "type": "external" } ], "gene_names_uniprotkb": "CHD1; SYGP-ORF4", "gene_names_refseq": "CHD1", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD1; 3.6.4.-; Chromo domain-containing protein 1; Chromodomain helicase-like DNA-binding protein 1", "protein_names_refseq": "chromatin-remodeling ATPase CHD1", "tax_id": 559292, "disease": "CHARGE syndrome (Disease Ontology:DOID:0050834); autism spectrum disorder (Disease Ontology:DOID:0060041); myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); developmental and epileptic encephalopathy 94 (Disease Ontology:DOID:0081325); prostate cancer (Disease Ontology:DOID:10283); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (sce:YER164W)", "pathway_count": 1, "publication_count": 52, "publication_id_list": "10026213;10811623;11875433;12242279;12446794;12504018;12682017;12872131;14562106;14585955;15647753;15665377;16468993;16606615;17098252;17259992;17287358;17330950;17433364;17563356;17576814;17620414;17949749;18245327;18407956;19684113;19779198;20702584;20832723;21126336;21177495;21623345;22033927;22814378;22922743;23749301;24374639;25395991;29019976;30079888;32597660;33174727;33229814;33481703;33491328;33502312;33846633;34965436;35173352;39270644;9169868;9326634", "class_list": "", "function": "ATP-dependent chromatin-remodeling factor which functions as substrate recognition component for the transcription regulatory histone acetylation (HAT) complex SAGA. Recognizes H3K4me. Acts in opposition to the FACT complex in regulating polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the pol I transcription termination step. Negatively regulates DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 45, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D3DM72", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0000785 chromatin;GO:0035861 site of double-strand break;GO:0000124 SAGA complex", "go_biological_process": "GO:2000104 negative regulation of DNA-templated DNA replication;GO:0034728 nucleosome organization;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 5.8, "record_id": "P32657-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32660-1", "uniprot_id": [ { "id": "ATC5_YEAST", "url": "https://www.uniprot.org/uniprot/P32660", "type": "external" } ], "mass": 177798.0, "length": 1571, "protein_name": "Phospholipid-transporting ATPase DNF1", "gene_name": "DNF1", "organism": "Yeast", "refseq_name": "aminophospholipid-translocating P4-type ATPase DNF1", "refseq_ac": [ { "id": "NP_011093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011093", "type": "external" } ], "gene_names_uniprotkb": "DNF1; SYGP-ORF7", "gene_names_refseq": "DNF1", "protein_names_uniprotkb": "Phospholipid-transporting ATPase DNF1; 7.6.2.1; Flippase DNF1", "protein_names_refseq": "aminophospholipid-translocating P4-type ATPase DNF1", "tax_id": 559292, "disease": "progressive familial intrahepatic cholestasis 1 (Disease Ontology:DOID:0070226); intrahepatic cholestasis of pregnancy 1 (Disease Ontology:DOID:0070228); benign recurrent intrahepatic cholestasis 1 (Disease Ontology:DOID:0070231); intrahepatic cholestasis (Disease Ontology:DOID:1852)", "pathway": " (sce:YER166W)", "pathway_count": 1, "publication_count": 32, "publication_id_list": "12631737;16847258;17287358;17330950;17563356;18199685;18407956;19411703;19684113;19779198;19795423;19823750;19966303;20702584;21177495;22218487;22308393;22791719;23302692;23749301;24374639;24909858;27235400;30824614;31786280;32597660;33060204;33320091;33481703;33491328;35294892;9169868", "class_list": "", "function": "Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide, phosphatidylcholine, phosphatidylethanolamine, and small amounts of phosphatidylserine from the lumenal to the cytosolic leaflet of the cell membrane and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:12631737, PubMed:22308393, PubMed:22791719, PubMed:23302692, PubMed:31786280, PubMed:33060204, PubMed:33320091, PubMed:35294892). Does not appear to transport sphingomyelin, inositol phosphoceramide, or phosphatidic acid (PubMed:12631737, PubMed:22308393, PubMed:33320091). Required for efficient endocytosis (PubMed:12631737)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 39, "reported_mutagensis": 48, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM74", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0090555 phosphatidylethanolamine flippase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0045332 phospholipid translocation;GO:0007163 establishment or maintenance of cell polarity;GO:0099040 ceramide translocation", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P32660-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32768-1", "uniprot_id": [ { "id": "FLO1_YEAST", "url": "https://www.uniprot.org/uniprot/P32768", "type": "external" } ], "mass": 160668.0, "length": 1537, "protein_name": "Flocculation protein FLO1", "gene_name": "FLO1", "organism": "Yeast", "refseq_name": "flocculin FLO1", "refseq_ac": [ { "id": "NP_009424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009424", "type": "external" } ], "gene_names_uniprotkb": "FLO1; FLO2; FLO4; FLO8", "gene_names_refseq": "FLO1; FLO2; FLO4", "protein_names_uniprotkb": "Flocculation protein FLO1; Flocculin-1", "protein_names_refseq": "flocculin FLO1", "tax_id": 559292, "disease": "", "pathway": " (sce:YAR050W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11027318;12698276;15470092;16086015;18001350;24374639;25873380;7483845;7502576;7668043;7731988;8203162;8511970;8980634;9244284;9483793;9851992", "class_list": "", "function": "Cell wall protein that participates directly in adhesive cell-cell interactions during yeast flocculation, a reversible, asexual and Ca(2+)-dependent process in which cells adhere to form aggregates (flocs) consisting of thousands of cells. The lectin-like protein sticks out of the cell wall of flocculent cells and selectively binds mannose residues in the cell walls of adjacent cells. Activity is inhibited by mannose, but not by glucose, maltose, sucrose or galactose. Also involved in cell-substrate adhesion., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 14, "predicted_n_glycosites": 14, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "A7U4Y7;D6VPN7;Q58HH7;Q58HH8;Q58HH9;Q58HI0", "ec_number_list": [], "go_molecular_function": "GO:0005537 D-mannose binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0000128 flocculation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P32768-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32769-1", "uniprot_id": [ { "id": "HBS1_YEAST", "url": "https://www.uniprot.org/uniprot/P32769", "type": "external" } ], "mass": 68730.0, "length": 611, "protein_name": "Elongation factor 1 alpha-like protein", "gene_name": "HBS1", "organism": "Yeast", "refseq_name": "ribosome dissociation factor GTPase HBS1", "refseq_ac": [ { "id": "NP_013010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013010", "type": "external" } ], "gene_names_uniprotkb": "HBS1; YKR404", "gene_names_refseq": "HBS1", "protein_names_uniprotkb": "Elongation factor 1 alpha-like protein; 3.6.5.-", "protein_names_refseq": "ribosome dissociation factor GTPase HBS1", "tax_id": 559292, "disease": "beta thalassemia (Disease Ontology:DOID:12241)", "pathway": " (sce:YKR084C); (R-SCE-429958); (R-SCE-9954714)", "pathway_count": 3, "publication_count": 24, "publication_id_list": "11909951;1394434;14562095;14562106;16554824;17330950;18407956;19779198;20702584;20947765;21102444;21126336;21177495;21623367;22218487;23749301;24374639;27995908;30516470;32597660;33481703;33491328;8196765;8203164", "class_list": "", "function": "GTPase component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:16554824, PubMed:20947765, PubMed:21102444). The Dom34-Hbs1 complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:16554824, PubMed:20947765). Following ribosome-binding, the Pelota-HBS1L complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:16554824, PubMed:20947765). The Dom34-Hbs1 complex is also involved in non-functional rRNA decay (PubMed:21102444)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXE4", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1990533 Dom34-Hbs1 complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0070651 nonfunctional rRNA decay;GO:0006412 translation;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P32769-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32771-1", "uniprot_id": [ { "id": "FADH_YEAST", "url": "https://www.uniprot.org/uniprot/P32771", "type": "external" } ], "mass": 41042.0, "length": 386, "protein_name": "S-(hydroxymethyl)glutathione dehydrogenase", "gene_name": "SFA1", "organism": "Yeast", "refseq_name": "bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase", "refseq_ac": [ { "id": "NP_010113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010113", "type": "external" } ], "gene_names_uniprotkb": "SFA1; SFA", "gene_names_refseq": "ADH5; SFA1", "protein_names_uniprotkb": "S-(hydroxymethyl)glutathione dehydrogenase; 1.1.1.-; 1.1.1.1; 1.1.1.284; Alcohol dehydrogenase SFA; FALDH; FDH; FLD; GSH-FDH; Glutathione-dependent formaldehyde dehydrogenase", "protein_names_refseq": "bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase", "tax_id": 559292, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); late onset Parkinson's disease (Disease Ontology:DOID:0060892); AMED syndrome (Disease Ontology:DOID:0080952); cholestasis (Disease Ontology:DOID:13580); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841)", "pathway": " (sce:YDL168W); (R-SCE-211935); (R-SCE-2161541); (R-SCE-5365859); (R-SCE-71384)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "11260719;14562095;14562106;16823961;24374639;33491328;7649298;8483449;9169867", "class_list": "", "function": "Oxidizes long-chain alcohols and, in the presence of glutathione, is able to oxidize formaldehyde (PubMed:8483449). Is responsible for yeast resistance to formaldehyde (PubMed:7649298). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation (PubMed:11260719)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRI3", "ec_number_list": [ { "id": "1.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.1", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.78", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.284", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.284", "type": "external" } ], "go_molecular_function": "GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0008270 zinc ion binding;GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity;GO:0080007 S-nitrosoglutathione reductase (NADH) activity;GO:0106321 S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0046294 formaldehyde catabolic process;GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway;GO:0033859 furaldehyde metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P32771-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32773-1", "uniprot_id": [ { "id": "TOA1_YEAST", "url": "https://www.uniprot.org/uniprot/P32773", "type": "external" } ], "mass": 32201.0, "length": 286, "protein_name": "Transcription initiation factor IIA large subunit", "gene_name": "TOA1", "organism": "Yeast", "refseq_name": "transcription initiation factor IIA large subunit", "refseq_ac": [ { "id": "NP_014837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014837", "type": "external" } ], "gene_names_uniprotkb": "TOA1", "gene_names_refseq": "TOA1", "protein_names_uniprotkb": "Transcription initiation factor IIA large subunit; TFIIA 32 kDa subunit; TFIIA large subunit", "protein_names_refseq": "transcription initiation factor IIA large subunit", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR194C); (R-SCE-674695); (R-SCE-6807505); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-9018519)", "pathway_count": 8, "publication_count": 8, "publication_id_list": "10082550;10525531;1546313;17322287;24374639;33491328;8610010;9169874", "class_list": "", "function": "TFIIA is a component of the transcription machinery of RNA polymerase II and implicated in the regulation of basal transcription. Interacts with TBP (the TATA-binding protein)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2Q3;E9P936", "ec_number_list": [], "go_molecular_function": "GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0003712 transcription coregulator activity;GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005672 transcription factor TFIIA complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P32773-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32781-1", "uniprot_id": [ { "id": "AGA2_YEAST", "url": "https://www.uniprot.org/uniprot/P32781", "type": "external" } ], "mass": 9464.0, "length": 87, "protein_name": "A-agglutinin-binding subunit", "gene_name": "AGA2", "organism": "Yeast", "refseq_name": "Aga2p", "refseq_ac": [ { "id": "NP_011483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011483", "type": "external" } ], "gene_names_uniprotkb": "AGA2", "gene_names_refseq": "AGA2", "protein_names_uniprotkb": "A-agglutinin-binding subunit", "protein_names_refseq": "Aga2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL032C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11292808;14562106;1756718;24374639;7957044;9169869", "class_list": "", "function": "Receptor binding subunit of the a-agglutinin heterodimer. S.cerevisiae a and alpha cells express the complementary cell surface glycoproteins a-agglutinin and alpha-agglutinin, respectively, which interact with one another to promote cellular aggregation during mating., [UniProtKB, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6VUA6", "ec_number_list": [], "go_molecular_function": "GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0000324 fungal-type vacuole;GO:0009277 fungal-type cell wall", "go_biological_process": "GO:0000752 agglutination involved in conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P32781-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32783-1", "uniprot_id": [ { "id": "MCES_YEAST", "url": "https://www.uniprot.org/uniprot/P32783", "type": "external" } ], "mass": 50341.0, "length": 436, "protein_name": "mRNA cap guanine-N(7) methyltransferase", "gene_name": "ABD1", "organism": "Yeast", "refseq_name": "mRNA (guanine-N7)-methyltransferase", "refseq_ac": [ { "id": "NP_009795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009795", "type": "external" } ], "gene_names_uniprotkb": "ABD1; YBR1602", "gene_names_refseq": "ABD1", "protein_names_uniprotkb": "mRNA cap guanine-N(7) methyltransferase; 2.1.1.56; mRNA (guanine-N(7))-methyltransferase; mRNA cap methyltransferase", "protein_names_refseq": "mRNA (guanine-N7)-methyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR236C); (R-SCE-72086); (R-SCE-77075)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11018011;11472630;17322287;20190278;24374639;33481703;33491328;7623811;7813418;8552073;9169431", "class_list": "", "function": "Responsible for methylating the 5'-cap structure of mRNAs., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 33, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQN2;Q6B2G0", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.1.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.56", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.7.50", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.50", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006370 7-methylguanosine mRNA capping", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P32783-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32784-1", "uniprot_id": [ { "id": "GPT1_YEAST", "url": "https://www.uniprot.org/uniprot/P32784", "type": "external" } ], "mass": 85694.0, "length": 759, "protein_name": "Glycerol-3-phosphate O-acyltransferase 1", "gene_name": "SCT1", "organism": "Yeast", "refseq_name": "bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1", "refseq_ac": [ { "id": "NP_009542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009542", "type": "external" } ], "gene_names_uniprotkb": "SCT1; GAT2; YBL0309; YBL0315", "gene_names_refseq": "GAT2; SCT1", "protein_names_uniprotkb": "Glycerol-3-phosphate O-acyltransferase 1; 2.3.1.15; 2.3.1.42; DHAP-AT 1; Dihydroxyacetone phosphate acyltransferase 1; G-3-P acyltransferase 1; GPAT 1; Glycerol-3-phosphate / dihydroxyacetone phosphate acyltransferase 1; Suppressor of choline-transport mutants 1", "protein_names_refseq": "bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL011W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11544256;12167660;1332308;1441753;14562095;14562106;18407956;19525420;19779198;20702584;21126336;22323296;23749301;24374639;29073188;32597660;33481703;33491328;7608137;7813418", "class_list": "", "function": "Dual substrate-specific glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase, catalyzing the first and committed reaction in the de novo synthesis of glycerophospholipids and triacylglycerols (TAGs). Prefers Gly-3-P over dihydroxyacetone phosphate and has a marked preference for 16-carbon fatty acyl chains. Transfers a fatty acid from fatty acyl-CoA to the sn-1 position of glycerol-3-phosphate to produce lysophosphatidic acid (LysoPA). These lipids not only are precursors of glycerolipids, but also are dynamic components of signal transduction systems that control cell physiology (PubMed:11544256). SCT1 is the primary supplier of diacylglycerols (DAG), used mainly in TAG synthesis and phosphatidylcholine (PC) synthesis through the CDP-choline pathway (PubMed:12167660). Regulates fatty acid desaturation, that is, the ratio of unsaturated versus saturated fatty acyl chains, by competing with the desaturase OLE1 for the common substrate C16:0-CoA. Sequesters C16:0-CoA into lipids, thereby shielding it from desaturation by OLE1 (PubMed:22323296)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPY8;Q07062;Q96TV1", "ec_number_list": [ { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" } ], "go_molecular_function": "GO:0016287 glycerone-phosphate O-acyltransferase activity;GO:0004366 glycerol-3-phosphate O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008654 phospholipid biosynthetic process;GO:0016024 CDP-diacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P32784-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32789-1", "uniprot_id": [ { "id": "ALK2_YEAST", "url": "https://www.uniprot.org/uniprot/P32789", "type": "external" } ], "mass": 76372.0, "length": 676, "protein_name": "Serine/threonine-protein kinase Haspin homolog ALK2", "gene_name": "ALK2", "organism": "Yeast", "refseq_name": "protein kinase ALK2", "refseq_ac": [ { "id": "NP_009544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009544", "type": "external" } ], "gene_names_uniprotkb": "ALK2; YBL0317", "gene_names_refseq": "ALK2", "protein_names_uniprotkb": "Serine/threonine-protein kinase Haspin homolog ALK2; 2.7.11.1", "protein_names_refseq": "protein kinase ALK2", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL009W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "1441753;16855400;19779198;19795423;19823750;20489023;22814378;23749301;24374639;32597660;33481703;33491328;34965436;7813418", "class_list": "", "function": "Serine/threonine haspin-like protein kinase involved in cell cycle regulation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPZ0", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0072354 histone H3T3 kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0035556 intracellular signal transduction;GO:0006974 DNA damage response;GO:0044879 mitotic morphogenesis checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P32789-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32796-1", "uniprot_id": [ { "id": "CACP_YEAST", "url": "https://www.uniprot.org/uniprot/P32796", "type": "external" } ], "mass": 77242.0, "length": 670, "protein_name": "Carnitine O-acetyltransferase, mitochondrial", "gene_name": "CAT2", "organism": "Yeast", "refseq_name": "carnitine O-acetyltransferase CAT2", "refseq_ac": [ { "id": "NP_013670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013670", "type": "external" } ], "gene_names_uniprotkb": "CAT2; CAT; YCAT; YM8054.01", "gene_names_refseq": "CAT2; YCAT", "protein_names_uniprotkb": "Carnitine O-acetyltransferase, mitochondrial; 2.3.1.7; Carnitine acetylase", "protein_names_refseq": "carnitine O-acetyltransferase CAT2", "tax_id": 559292, "disease": "congenital myasthenic syndrome 6 (Disease Ontology:DOID:0110671); neurodegeneration with brain iron accumulation (Disease Ontology:DOID:0110734); Alzheimer's disease (Disease Ontology:DOID:10652); depressive disorder (Disease Ontology:DOID:1596); asthma (Disease Ontology:DOID:2841); congenital myasthenic syndrome (Disease Ontology:DOID:3635)", "pathway": " (sce:YML042W); (R-SCE-1483191); (R-SCE-264642); (R-SCE-389887); (R-SCE-70895); (R-SCE-9033241)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "14562106;24374639;7628448;8420957;9169872", "class_list": "", "function": "Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZD3", "ec_number_list": [ { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.4", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.56", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" } ], "go_molecular_function": "GO:0004092 carnitine O-acetyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005777 peroxisome", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0009437 carnitine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P32796-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32798-1", "uniprot_id": [ { "id": "COT1_YEAST", "url": "https://www.uniprot.org/uniprot/P32798", "type": "external" } ], "mass": 48155.0, "length": 439, "protein_name": "Vacuolar zinc transporter COT1", "gene_name": "COT1", "organism": "Yeast", "refseq_name": "metal cation transporter COT1", "refseq_ac": [ { "id": "NP_014961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014961", "type": "external" } ], "gene_names_uniprotkb": "COT1; O6131", "gene_names_refseq": "COT1", "protein_names_uniprotkb": "Vacuolar zinc transporter COT1; Cobalt toxicity protein 1", "protein_names_refseq": "metal cation transporter COT1", "tax_id": 559292, "disease": "hypermanganesemia with dystonia 1 (Disease Ontology:DOID:0080536)", "pathway": " (sce:YOR316C); (R-SCE-425410)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10856230;12556516;14557538;14562106;1508175;16169922;17287358;18407956;18930916;19779198;22842922;23749301;24374639;32597660;33481703;33491328;8896266;9169874;9712830", "class_list": "", "function": "Vacuolar transporter that regulates zinc homeostasis by mediating zinc transport and storage into the vacuole (PubMed:10856230, PubMed:12556516, PubMed:9712830). Plays a role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm (PubMed:12556516). May also participate in the regulation of cobalt levels under normal physiological conditions and may be important in the supply of metal that is required for metalloenzyme or cofactor synthesis (PubMed:1508175, PubMed:18930916). Involved in the resistance to cobalt and rhodium ions (PubMed:1508175)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W314", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0015087 cobalt ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045121 membrane raft;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0006882 intracellular zinc ion homeostasis;GO:0006824 cobalt ion transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P32798-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32801-1", "uniprot_id": [ { "id": "ELM1_YEAST", "url": "https://www.uniprot.org/uniprot/P32801", "type": "external" } ], "mass": 72150.0, "length": 640, "protein_name": "Serine/threonine-protein kinase ELM1", "gene_name": "ELM1", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase ELM1", "refseq_ac": [ { "id": "NP_012876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012876", "type": "external" } ], "gene_names_uniprotkb": "ELM1; YKL261", "gene_names_refseq": "ELM1; LDB9", "protein_names_uniprotkb": "Serine/threonine-protein kinase ELM1; 2.7.11.1", "protein_names_refseq": "serine/threonine protein kinase ELM1", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL048C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12917352;14562106;18231587;18407956;19779198;21126336;23749301;24374639;32597660;33481703;33491328;8154189;8196765;8395007", "class_list": "", "function": "Important role in G1 events required for bud emergence and septin organization. Coordinates cell growth and cell division at G2/M, essential for efficient cytokinesis and for regulation of SWE1., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXN9", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000144 cellular bud neck septin ring;GO:0005935 cellular bud neck", "go_biological_process": "GO:0000902 cell morphogenesis;GO:0042149 cellular response to glucose starvation;GO:0000281 mitotic cytokinesis;GO:0000921 septin ring assembly;GO:0000023 maltose metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P32801-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32802-1", "uniprot_id": [ { "id": "TMN1_YEAST", "url": "https://www.uniprot.org/uniprot/P32802", "type": "external" } ], "mass": 75963.0, "length": 667, "protein_name": "Transmembrane 9 superfamily member 1", "gene_name": "EMP70", "organism": "Yeast", "refseq_name": "Emp70p", "refseq_ac": [ { "id": "NP_013184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013184", "type": "external" } ], "gene_names_uniprotkb": "EMP70; L2385; L9449.11; TMN1", "gene_names_refseq": "EMP70; TMN1", "protein_names_uniprotkb": "Transmembrane 9 superfamily member 1; 70 kDa endomembrane protein; Acidic 24 kDa late endocytic intermediate component; Endomembrane protein EMP70", "protein_names_refseq": "Emp70p", "tax_id": 559292, "disease": "acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (sce:YLR083C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16847258;18178563;20681974;24374639;8314797;9169871;9729438", "class_list": "", "function": "With TMN2 and TMN3, plays a critical role in the late stages of a nutrient-controlled pathway notably regulating FLO11 gene expression. Acts downstream of RAS2 and TOR. Essential for cell adhesion and filamentous growth. May play a role as effector of cellular copper homeostasis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VY83;Q12101", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005768 endosome;GO:0010008 endosome membrane;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0007034 vacuolar transport;GO:0006811 monoatomic ion transport;GO:0006878 intracellular copper ion homeostasis;GO:0016197 endosomal transport;GO:0072657 protein localization to membrane", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32802-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32803-1", "uniprot_id": [ { "id": "EMP24_YEAST", "url": "https://www.uniprot.org/uniprot/P32803", "type": "external" } ], "mass": 23332.0, "length": 203, "protein_name": "Endosomal protein P24B", "gene_name": "EMP24", "organism": "Yeast", "refseq_name": "Emp24p", "refseq_ac": [ { "id": "NP_011315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011315", "type": "external" } ], "gene_names_uniprotkb": "EMP24; G1271", "gene_names_refseq": "BST2; EMP24", "protein_names_uniprotkb": "Endosomal protein P24B; 24 kDa endomembrane protein; Basic 24 kDa late endocytic intermediate component", "protein_names_refseq": "Emp24p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL200C); (R-SCE-6807878); (R-SCE-6811434)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10359606;10713261;11560939;14562106;16847258;24374639;7729411;8314797;8900179;9046087;9169869", "class_list": "", "function": "Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTV4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005798 Golgi-associated vesicle;GO:0030134 COPII-coated ER to Golgi transport vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006900 vesicle budding from membrane;GO:0016050 vesicle organization;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P32803-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32804-1", "uniprot_id": [ { "id": "ZRT1_YEAST", "url": "https://www.uniprot.org/uniprot/P32804", "type": "external" } ], "mass": 41582.0, "length": 376, "protein_name": "High-affinity zinc transporter ZRT1", "gene_name": "ZRT1", "organism": "Yeast", "refseq_name": "high-affinity Zn(2+) transporter ZRT1", "refseq_ac": [ { "id": "NP_011259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011259", "type": "external" } ], "gene_names_uniprotkb": "ZRT1; NRC376", "gene_names_refseq": "ZRT1", "protein_names_uniprotkb": "High-affinity zinc transporter ZRT1; Zinc-regulated transporter 1", "protein_names_refseq": "high-affinity Zn(2+) transporter ZRT1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL255W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "19684113;19779198;21177495;22218487;23749301;24374639;24909858;25454947;33481703;33491328;8322518;8637895;8798516;8972578;9169869", "class_list": "", "function": "High-affinity zinc transport protein., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV80", "ec_number_list": [], "go_molecular_function": "GO:0000006 high-affinity zinc transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0071578 zinc ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P32804-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32807-1", "uniprot_id": [ { "id": "KU70_YEAST", "url": "https://www.uniprot.org/uniprot/P32807", "type": "external" } ], "mass": 70647.0, "length": 602, "protein_name": "ATP-dependent DNA helicase II subunit 1", "gene_name": "YKU70", "organism": "Yeast", "refseq_name": "ATP-dependent DNA helicase YKU70", "refseq_ac": [ { "id": "NP_014011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014011", "type": "external" } ], "gene_names_uniprotkb": "YKU70; HDF1; NES24; YM8021.10", "gene_names_refseq": "HDF1; NES24; YKU70", "protein_names_uniprotkb": "ATP-dependent DNA helicase II subunit 1; 3.6.4.12; ATP-dependent DNA helicase II subunit Ku70; High affinity DNA-binding factor subunit 1", "protein_names_refseq": "ATP-dependent DNA helicase YKU70", "tax_id": 559292, "disease": "squamous cell carcinoma (Disease Ontology:DOID:1749); basal cell carcinoma (Disease Ontology:DOID:2513)", "pathway": " (sce:YMR284W); (R-SCE-6798695)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10675560;11046137;12138180;12975323;14562106;14585978;15738391;16951060;17287358;17322287;24374639;33491328;8017106;8509423;8626469;8668537;9169872;9635192;9635193;9663392;9914366", "class_list": "", "function": "Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Appears to have a role in recruitment of telomerase and CDC13 to the telomere and the subsequent telomere elongation. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0B1;P32498;Q0P778;Q0P779;Q0P787;Q0P789;Q6B267", "ec_number_list": [ { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.4.23.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.25", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "2.7.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.7.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.59", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.3.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0003684 damaged DNA binding;GO:0016887 ATP hydrolysis activity;GO:0042162 telomeric DNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0000781 chromosome, telomeric region;GO:0043564 Ku70:Ku80 complex", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0000723 telomere maintenance;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0006325 chromatin organization;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P32807-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32828-1", "uniprot_id": [ { "id": "SLX5_YEAST", "url": "https://www.uniprot.org/uniprot/P32828", "type": "external" } ], "mass": 71071.0, "length": 619, "protein_name": "E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5", "gene_name": "SLX5", "organism": "Yeast", "refseq_name": "SUMO-targeted ubiquitin ligase complex subunit SLX5", "refseq_ac": [ { "id": "NP_010271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010271", "type": "external" } ], "gene_names_uniprotkb": "SLX5; D2875; HEX3", "gene_names_refseq": "HEX3; SLX5; ULS2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5; 2.3.2.27; Hexose metabolism-related protein HEX3; RING-type E3 ubiquitin transferase SLX5; Synthetic lethal of unknown function protein 5", "protein_names_refseq": "SUMO-targeted ubiquitin ligase complex subunit SLX5", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL013W)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "11139495;16325482;16387868;17591698;17669696;17848550;18032921;18086879;18407956;18499666;18948542;19270524;19779198;23749301;23785440;24374639;26906737;26960795;30479332;31015336;33229814;33481703;33491328;9169867", "class_list": "", "function": "Component of the SUMO-targeted ubiquitin ligase (STUbL) complex SLX5/SLX8 that mediates ubiquitination and subsequent desumoylation of sumoylated proteins and proteins containing SUMO-like domains for their degradation (PubMed:11139495, PubMed:16325482, PubMed:17669696, PubMed:17848550, PubMed:18032921, PubMed:18499666, PubMed:18948542, PubMed:31015336). The STUbL complex SLX5/SLX8 stimulates ubiquitin conjugating enzymes, including UBC1, UBC4, UBC5 and UBC13-MMS2, and mediates the proteolytic down-regulation of sumoylated proteins (PubMed:18032921). The STUbL complex SLX5/SLX8 is involved in ubiquitin-mediated degradation of histone variant CSE4, preventing mislocalization to euchromatin (PubMed:26960795). The complex plays an essential role in maintenance of chromosome stability and links SUMO-dependent ubiquitination to a centromere-specific function during mitosis (PubMed:23785440). The complex is involved in proteolysis of spindle positioning protein KAR9 and ensures correct spindle function by regulating levels of microtubule-associated proteins (PubMed:26906737). During replication, the complex helps prevent DNA lesions via recombination and has a role in localizing the DNA damage protein DCD2 (PubMed:16325482, PubMed:17591698). The complex especially ubiquitinates the nuclease YEN1 and prevents persistent accumulation of a fraction of YEN1 associated with sites of activity in late G2/M and helps maintain the balance between pro- and anti-crossover pathways during homologous recombination (PubMed:30479332). It is also involved in ubiquitin-mediated degradation of DNA repair proteins RAD52 and RAD57 (PubMed:18032921). Along with SIR2, promotes silencing of genes at telomeric or ribosomal DNA (rDNA) loci (PubMed:18086879). Finally, the complex is recruited to distinct genomic hotspots of non-H2B protein ubiquitination (ub-hotspots) by the sumoylated transcription factor-like protein EUC1 where it ubiquitinates EUC1 and presumably other targets (PubMed:31015336)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VRX6", "ec_number_list": [], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0032183 SUMO binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0000776 kinetochore;GO:0033768 SUMO-targeted ubiquitin ligase complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process;GO:0000723 telomere maintenance;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P32828-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32833-1", "uniprot_id": [ { "id": "ORC2_YEAST", "url": "https://www.uniprot.org/uniprot/P32833", "type": "external" } ], "mass": 71238.0, "length": 620, "protein_name": "Origin recognition complex subunit 2", "gene_name": "ORC2", "organism": "Yeast", "refseq_name": "origin recognition complex subunit 2", "refseq_ac": [ { "id": "NP_009616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009616", "type": "external" } ], "gene_names_uniprotkb": "ORC2; RRR1; SIR5; YBR0523", "gene_names_refseq": "ORC2; RRR1; SIR5", "protein_names_uniprotkb": "Origin recognition complex subunit 2; Origin recognition complex 71 kDa subunit", "protein_names_refseq": "origin recognition complex subunit 2", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR060C); (R-SCE-176187); (R-SCE-68616); (R-SCE-68689); (R-SCE-68962)", "pathway_count": 5, "publication_count": 23, "publication_id_list": "11168584;14562106;17563356;17825064;18407956;19068484;19779198;19795423;19823750;20702584;21126336;21177495;21289063;23749301;24374639;30516470;32597660;33481703;33491328;7813418;8232543;8266071;8266072", "class_list": "", "function": "Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 38, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ60", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005656 nuclear pre-replicative complex;GO:0031261 DNA replication preinitiation complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005664 nuclear origin of replication recognition complex", "go_biological_process": "GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication;GO:0031509 subtelomeric heterochromatin formation;GO:0006270 DNA replication initiation;GO:0030466 silent mating-type cassette heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P32833-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32838-1", "uniprot_id": [ { "id": "PP2A4_YEAST", "url": "https://www.uniprot.org/uniprot/P32838", "type": "external" } ], "mass": 42433.0, "length": 368, "protein_name": "Serine/threonine-protein phosphatase PP2A-like PPG1", "gene_name": "PPG1", "organism": "Yeast", "refseq_name": "putative serine/threonine-protein kinase PPG1", "refseq_ac": [ { "id": "NP_014429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014429", "type": "external" } ], "gene_names_uniprotkb": "PPG1; N3281; PPG", "gene_names_refseq": "PPG1", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase PP2A-like PPG1; 3.1.3.16", "protein_names_refseq": "putative serine/threonine-protein kinase PPG1", "tax_id": 559292, "disease": "", "pathway": " (sce:YNR032W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14551259;14562106;15447631;17322287;24374639;33491328;7678255;9169873", "class_list": "", "function": "Involved in glycogen accumulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1K6;E9P8U5", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.43", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1901525 negative regulation of mitophagy;GO:0010506 regulation of autophagy;GO:0005977 glycogen metabolic process;GO:0071444 cellular response to pheromone;GO:1903939 regulation of TORC2 signaling", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P32838-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32839-1", "uniprot_id": [ { "id": "BCS1_YEAST", "url": "https://www.uniprot.org/uniprot/P32839", "type": "external" } ], "mass": 51107.0, "length": 456, "protein_name": "Mitochondrial chaperone BCS1", "gene_name": "BCS1", "organism": "Yeast", "refseq_name": "bifunctional AAA family ATPase chaperone/translocase BCS1", "refseq_ac": [ { "id": "NP_010663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010663", "type": "external" } ], "gene_names_uniprotkb": "BCS1; D9481.17", "gene_names_refseq": "BCS1", "protein_names_uniprotkb": "Mitochondrial chaperone BCS1; 3.6.1.-", "protein_names_refseq": "bifunctional AAA family ATPase chaperone/translocase BCS1", "tax_id": 559292, "disease": "Bjornstad syndrome (Disease Ontology:DOID:0050677); mitochondrial complex III deficiency nuclear type 1 (Disease Ontology:DOID:0080111); GRACILE syndrome (Disease Ontology:DOID:0111455)", "pathway": " (sce:YDR375C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10508156;1327750;14562106;17287358;24374639;8599931;9169867", "class_list": "", "function": "Chaperone necessary for the incorporation of Rieske iron-sulfur protein RIP1 into the mitochondrial respiratory chain complex III., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT07;Q06404", "ec_number_list": [ { "id": "1.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.2.3", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "7.1.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.8", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0034551 mitochondrial respiratory chain complex III assembly;GO:0051131 chaperone-mediated protein complex assembly;GO:0032979 protein insertion into mitochondrial inner membrane from matrix", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32839-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32842-1", "uniprot_id": [ { "id": "VATL2_YEAST", "url": "https://www.uniprot.org/uniprot/P32842", "type": "external" } ], "mass": 17037.0, "length": 164, "protein_name": "V-type proton ATPase subunit c'", "gene_name": "VMA11", "organism": "Yeast", "refseq_name": "H(+)-transporting V0 sector ATPase subunit c'", "refseq_ac": [ { "id": "NP_015090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015090", "type": "external" } ], "gene_names_uniprotkb": "VMA11; CLS9; P1064; TFP3", "gene_names_refseq": "CLS9; TFP3; VMA11", "protein_names_uniprotkb": "V-type proton ATPase subunit c'; Proteolipid protein VMA11; Trifluoperazine resistance protein 3; V-ATPase 16 kDa proteolipid subunit 2; V-ATPase subunit c'; Vacuolar proton pump c' subunit", "protein_names_refseq": "H(+)-transporting V0 sector ATPase subunit c'", "tax_id": 559292, "disease": "early-onset epilepsy 3 (Disease Ontology:DOID:0070472); thyroid gland carcinoma (Disease Ontology:DOID:3963)", "pathway": " (sce:YPL234C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562106;16847258;17322287;1837023;2192255;24374639;27776355;29526695;9030535;9169875", "class_list": "", "function": "Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:1837023, PubMed:9030535). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:1837023, PubMed:9030535)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3D6;P32365", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane;GO:0071944 cell periphery;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0048388 endosomal lumen acidification;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport;GO:0061795 Golgi lumen acidification", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P32842-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32849-1", "uniprot_id": [ { "id": "RAD5_YEAST", "url": "https://www.uniprot.org/uniprot/P32849", "type": "external" } ], "mass": 134002.0, "length": 1169, "protein_name": "DNA-dependent ATPase/E3 ubiquitin-protein ligase RAD5", "gene_name": "RAD5", "organism": "Yeast", "refseq_name": "DNA helicase RAD5", "refseq_ac": [ { "id": "NP_013132", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013132", "type": "external" } ], "gene_names_uniprotkb": "RAD5; REV2; SNM2", "gene_names_refseq": "RAD5; REV2; SNM2", "protein_names_uniprotkb": "DNA-dependent ATPase/E3 ubiquitin-protein ligase RAD5; 2.3.2.27; 3.6.4.-; DNA damage tolerance protein RAD5; Radiation sensitivity protein 5; Revertibility protein 2", "protein_names_refseq": "DNA helicase RAD5", "tax_id": 559292, "disease": "gastrointestinal system cancer (Disease Ontology:DOID:3119)", "pathway": " (sce:YLR032W)", "pathway_count": 1, "publication_count": 32, "publication_id_list": "10880451;10924462;11884624;12226657;12496280;1324406;1394508;14562095;14562106;16224103;17936713;18407956;19779198;19795423;19823750;22814378;23142547;23749301;24374639;25690888;27001510;29742437;30256854;31350889;33436623;33481703;33491328;36623584;37594077;7961763;9016623;9169871", "class_list": "", "function": "Promotes two parallel branches of the DNA damage tolerance (DDT) pathway (also known as the post-replication repair (PRR) pathway) that bypass replication-blocking lesions without removing them; the translesion DNA synthesis (TLS) branch and the template-switching (TS) branch (PubMed:10880451, PubMed:10924462, PubMed:11884624, PubMed:12226657, PubMed:12496280, PubMed:1324406, PubMed:17936713, PubMed:23142547, PubMed:25690888, PubMed:27001510, PubMed:29742437, PubMed:31350889, PubMed:33436623, PubMed:36623584, PubMed:37594077, PubMed:7961763, PubMed:9016623). To facilitate translesion DNA synthesis, recruits deoxycytidyl transferase/scaffolding protein REV1 to monoubiquitinated POL30/PCNA; this is required for translesion synthesis at 1,N6-ethenoadenine DNA adducts (PubMed:23142547, PubMed:27001510, PubMed:37594077). To initiate template-switching, catalyzes the 'Lys-63'-linked polyubiquitination of monoubiquitinated POL30/PCNA, in conjunction with the ubiquitin-conjugating enzymes MMS2 and UBC13 (PubMed:10880451, PubMed:11884624, PubMed:12226657, PubMed:12496280). In the chicken foot model of template switching, drives the ATP-dependent unwinding of the leading arm, which results in replication fork reversal and formation of a four-way DNA junction termed a chicken foot intermediate (PubMed:1324406, PubMed:17936713, PubMed:25690888, PubMed:29742437, PubMed:31350889, PubMed:33436623, PubMed:36623584, PubMed:7961763). In the chicken foot intermediate, the template is switched from the stalled leading strand to the newly synthesized sister/lagging strand, that can be extended by DNA polymerases; this results in the bypass of the DNA damage in the leading strand once the extended chicken foot is converted back to a replication fork (PubMed:1324406, PubMed:17936713, PubMed:25690888, PubMed:29742437, PubMed:31350889, PubMed:33436623, PubMed:36623584, PubMed:7961763). The enzyme reportedly lacks classical helicase activity; its ATPase activity is dependent upon binding of replication fork-like DNA, and it has been shown to catalyze the concerted unwinding and annealing of nascent and parental strands without exposing extended single-stranded regions, or to only unwind the leading arm (PubMed:17936713, PubMed:25690888, PubMed:7961763). Has also been implicated in double-strand break repair, possibly by circumventing non-homologous end-joining (PubMed:16224103, PubMed:9016623)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY34", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0061630 ubiquitin protein ligase activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006281 DNA repair;GO:0006302 double-strand break repair;GO:0006325 chromatin organization;GO:0000209 protein polyubiquitination;GO:0019985 translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P32849-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32854-1", "uniprot_id": [ { "id": "PEP12_YEAST", "url": "https://www.uniprot.org/uniprot/P32854", "type": "external" } ], "mass": 33006.0, "length": 288, "protein_name": "Syntaxin PEP12", "gene_name": "PEP12", "organism": "Yeast", "refseq_name": "SNAP receptor PEP12", "refseq_ac": [ { "id": "NP_014679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014679", "type": "external" } ], "gene_names_uniprotkb": "PEP12; OR26.29; VPS6; VPT13", "gene_names_refseq": "PEP12; VPL6; VPS6; VPT13", "protein_names_uniprotkb": "Syntaxin PEP12; Carboxypeptidase Y-deficient protein 12; Vacuolar protein sorting-associated protein 6; Vacuolar protein-targeting protein 13", "protein_names_refseq": "SNAP receptor PEP12", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305)", "pathway": " (sce:YOR036W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11788821;17330950;18407956;19779198;23749301;24374639;30516470;33481703;33491328;8730101;9169874", "class_list": "", "function": "Plays a role in the sorting and targeting of vacuolar proteases., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2A3", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0012505 endomembrane system", "go_biological_process": "GO:0048210 Golgi vesicle fusion to target membrane;GO:0006886 intracellular protein transport;GO:0016236 macroautophagy;GO:0006895 Golgi to endosome transport;GO:0000011 vacuole inheritance", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P32854-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32855-1", "uniprot_id": [ { "id": "SEC8_YEAST", "url": "https://www.uniprot.org/uniprot/P32855", "type": "external" } ], "mass": 122225.0, "length": 1065, "protein_name": "Exocyst complex component SEC8", "gene_name": "SEC8", "organism": "Yeast", "refseq_name": "exocyst subunit SEC8", "refseq_ac": [ { "id": "NP_015380", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015380", "type": "external" } ], "gene_names_uniprotkb": "SEC8; YP9499.11", "gene_names_refseq": "SEC8", "protein_names_uniprotkb": "Exocyst complex component SEC8", "protein_names_refseq": "exocyst subunit SEC8", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR055W); (R-SCE-264876)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "1512289;17563356;18407956;19684113;19779198;22814378;23749301;24374639;33229814;33491328;9169875", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W461", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0000145 exocyst;GO:0000131 incipient cellular bud site;GO:0005628 prospore membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006887 exocytosis;GO:0006893 Golgi to plasma membrane transport;GO:0006904 vesicle docking involved in exocytosis;GO:0090522 vesicle tethering involved in exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P32855-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32860-1", "uniprot_id": [ { "id": "NFU1_YEAST", "url": "https://www.uniprot.org/uniprot/P32860", "type": "external" } ], "mass": 29174.0, "length": 256, "protein_name": "NifU-like protein, mitochondrial", "gene_name": "NFU1", "organism": "Yeast", "refseq_name": "Nfu1p", "refseq_ac": [ { "id": "NP_012884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012884", "type": "external" } ], "gene_names_uniprotkb": "NFU1; NUB1; YKL253", "gene_names_refseq": "NFU1; NUB1", "protein_names_uniprotkb": "NifU-like protein, mitochondrial", "protein_names_refseq": "Nfu1p", "tax_id": 559292, "disease": "hereditary spastic paraplegia 93 (Disease Ontology:DOID:0070645); multiple mitochondrial dysfunctions syndrome 1 (Disease Ontology:DOID:0080133)", "pathway": " (sce:YKL040C); (R-SCE-9857492)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10468587;14562106;1481573;17322287;19779198;24374639;27532773;33491328;8154189;8196765", "class_list": "", "function": "Involved in iron homeostasis within the mitochondrion where it is involved in the assembly of iron-sulfur proteins (PubMed:10468587, PubMed:27532773). Together with BOL3, required during the last step of iron-sulfur protein assembly when the iron-sulfur cluster is inserted into the target protein (PubMed:27532773). Required for protecting iron sulfur clusters from oxidative damage (PubMed:27532773)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXP6", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0051604 protein maturation;GO:0044572 [4Fe-4S] cluster assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P32860-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32861-1", "uniprot_id": [ { "id": "UGPA1_YEAST", "url": "https://www.uniprot.org/uniprot/P32861", "type": "external" } ], "mass": 55988.0, "length": 499, "protein_name": "UTP--glucose-1-phosphate uridylyltransferase", "gene_name": "UGP1", "organism": "Yeast", "refseq_name": "UTP glucose-1-phosphate uridylyltransferase", "refseq_ac": [ { "id": "NP_012889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012889", "type": "external" } ], "gene_names_uniprotkb": "UGP1; YKL248", "gene_names_refseq": "UGP1", "protein_names_uniprotkb": "UTP--glucose-1-phosphate uridylyltransferase; 2.7.7.9; UDP-glucose pyrophosphorylase; UDPGP; UGPase", "protein_names_refseq": "UTP glucose-1-phosphate uridylyltransferase", "tax_id": 559292, "disease": "developmental and epileptic encephalopathy 83 (Disease Ontology:DOID:0112218); cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YKL035W); (R-SCE-173599); (R-SCE-3322077)", "pathway_count": 3, "publication_count": 29, "publication_id_list": "11875433;12372297;14562106;1481573;15665377;17010990;17287358;17330950;17531808;17563356;18407956;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22814378;23749301;23865587;24374639;27821475;32597660;33229814;33481703;33491328;7588797;8196765", "class_list": "", "function": "Plays a central role as a glucosyl donor in cellular metabolic pathways., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VXQ0", "ec_number_list": [ { "id": "2.7.7.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.9", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity;GO:0070569 uridylyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0005978 glycogen biosynthetic process;GO:0006011 UDP-alpha-D-glucose metabolic process;GO:0005992 trehalose biosynthetic process;GO:0006078 (1->6)-beta-D-glucan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P32861-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32862-1", "uniprot_id": [ { "id": "RGT1_YEAST", "url": "https://www.uniprot.org/uniprot/P32862", "type": "external" } ], "mass": 128240.0, "length": 1170, "protein_name": "Glucose transport transcription regulator RGT1", "gene_name": "RGT1", "organism": "Yeast", "refseq_name": "Rgt1p", "refseq_ac": [ { "id": "NP_012886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012886", "type": "external" } ], "gene_names_uniprotkb": "RGT1; YKL251", "gene_names_refseq": "RGT1", "protein_names_uniprotkb": "Glucose transport transcription regulator RGT1; Restores glucose transport protein 1", "protein_names_refseq": "Rgt1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL038W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "12861007;14562095;14562106;1481573;15665377;16844691;17330950;17563356;18407956;1874412;19779198;20702584;21126336;23749301;24374639;30516470;32597660;33229814;33481703;33491328;8196765;8887670", "class_list": "", "function": "Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose. In the absence of glucose, it functions as a transcriptional repressor, whereas high concentrations of glucose cause it to function as a transcriptional activator. In cells growing on low levels of glucose, has a neutral role, neither repressing nor activating transcription. Binds the consensus binding site sequence 5'-CGGANNA-3', of which multiple copies are present in all HXT promoters regulated by RGT1., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 42, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VXP8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006006 glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P32862-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32864-1", "uniprot_id": [ { "id": "RAEP_YEAST", "url": "https://www.uniprot.org/uniprot/P32864", "type": "external" } ], "mass": 67374.0, "length": 603, "protein_name": "Rab proteins geranylgeranyltransferase component A", "gene_name": "MRS6", "organism": "Yeast", "refseq_name": "GTPase-activating protein MRS6", "refseq_ac": [ { "id": "NP_015015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015015", "type": "external" } ], "gene_names_uniprotkb": "MRS6; MSI4", "gene_names_refseq": "MRS6; MSI4", "protein_names_uniprotkb": "Rab proteins geranylgeranyltransferase component A; REP; Rab escort protein", "protein_names_refseq": "GTPase-activating protein MRS6", "tax_id": 559292, "disease": "asthma (Disease Ontology:DOID:2841); choroideremia (Disease Ontology:DOID:9821)", "pathway": " (sce:YOR370C); (R-SCE-6803205); (R-SCE-8873719); (R-SCE-8876198)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "14562106;15665377;17330950;17563356;18407956;19779198;19795423;19823750;21126336;23749301;24374639;30516470;32597660;33481703;33491328;7882424;8132658;8387377;9169874", "class_list": "", "function": "Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W363;Q06761", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0005092 GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0005968 Rab-protein geranylgeranyltransferase complex", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007264 small GTPase-mediated signal transduction;GO:0016192 vesicle-mediated transport;GO:0018344 protein geranylgeranylation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P32864-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32873-1", "uniprot_id": [ { "id": "BEM3_YEAST", "url": "https://www.uniprot.org/uniprot/P32873", "type": "external" } ], "mass": 124913.0, "length": 1128, "protein_name": "GTPase-activating protein BEM3", "gene_name": "BEM3", "organism": "Yeast", "refseq_name": "GTPase-activating protein BEM3", "refseq_ac": [ { "id": "NP_015210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015210", "type": "external" } ], "gene_names_uniprotkb": "BEM3; LPH12C", "gene_names_refseq": "BEM3", "protein_names_uniprotkb": "GTPase-activating protein BEM3; Bud emergence protein 3", "protein_names_refseq": "GTPase-activating protein BEM3", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL115C); (R-SCE-6798695); (R-SCE-8980692); (R-SCE-9013148); (R-SCE-9013149); (R-SCE-9013423); (R-SCE-9013424); (R-SCE-9035034)", "pathway_count": 8, "publication_count": 25, "publication_id_list": "14562106;15665377;17287358;17330950;17563356;17914457;18407956;19684113;19779198;19795423;19823750;20702584;21177495;22118465;23749301;24374639;24909858;32597660;33229814;33481703;33491328;34965436;8227021;8300560;9169875", "class_list": "", "function": "GTPase-activating protein (GAP) for CDC42 and less efficiently for RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 14, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 14, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 14, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 57, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "D6W3Q3", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0051286 cell tip;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030427 site of polarized growth", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0035024 negative regulation of Rho protein signal transduction;GO:0030010 establishment of cell polarity;GO:0031106 septin ring organization", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "P32873-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32874-1", "uniprot_id": [ { "id": "HFA1_YEAST", "url": "https://www.uniprot.org/uniprot/P32874", "type": "external" } ], "mass": 259163.0, "length": 2273, "protein_name": "Acetyl-CoA carboxylase, mitochondrial", "gene_name": "HFA1", "organism": "Yeast", "refseq_name": "acetyl-CoA carboxylase HFA1", "refseq_ac": [ { "id": "NP_013934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013934", "type": "external" } ], "gene_names_uniprotkb": "HFA1; YM8261.01C; YM8325.08C", "gene_names_refseq": "HFA1", "protein_names_uniprotkb": "Acetyl-CoA carboxylase, mitochondrial; 6.4.1.2; ACC", "protein_names_refseq": "acetyl-CoA carboxylase HFA1", "tax_id": 559292, "disease": "chromosome 17q12 deletion syndrome (Disease Ontology:DOID:0060404); muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YMR207C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;14576278;14761959;24374639;33229814;33491328;7906156;9169872", "class_list": "", "function": "Catalyzes the rate-limiting reaction in the mitochondrial fatty acid synthesis (FAS) type II pathway. Responsible for the production of the mitochondrial malonyl-CoA, used for the biosynthesis of the cofactor lipoic acid. This protein carries three functions: biotin carboxyl carrier protein, biotin carboxylase, and carboxyltransferase., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W032;O42823", "ec_number_list": [ { "id": "6.3.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.14", "type": "external" }, { "id": "6.4.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003989 acetyl-CoA carboxylase activity;GO:0004075 biotin carboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:2001295 malonyl-CoA biosynthetic process;GO:0042759 long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P32874-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32891-1", "uniprot_id": [ { "id": "DLD1_YEAST", "url": "https://www.uniprot.org/uniprot/P32891", "type": "external" } ], "mass": 65293.0, "length": 587, "protein_name": "D-lactate dehydrogenase [cytochrome] 1, mitochondrial", "gene_name": "DLD1", "organism": "Yeast", "refseq_name": "D-lactate dehydrogenase", "refseq_ac": [ { "id": "NP_010107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010107", "type": "external" } ], "gene_names_uniprotkb": "DLD1; DLD", "gene_names_refseq": "DLD1", "protein_names_uniprotkb": "D-lactate dehydrogenase [cytochrome] 1, mitochondrial; 1.1.2.4; D-LCR; D-lactate ferricytochrome C oxidoreductase", "protein_names_refseq": "D-lactate dehydrogenase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL174C); (R-SCE-9837999)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11502169;14562106;24374639;8492799;9169867", "class_list": "", "function": "Catalyzes the stereospecific oxidation of D-lactate to pyruvate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRH8;Q12360", "ec_number_list": [ { "id": "1.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.2.3", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "3.4.24.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.64", "type": "external" }, { "id": "2.5.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.39", "type": "external" }, { "id": "1.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.2.4", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.1", "type": "external" }, { "id": "1.1.99.40", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.99.40", "type": "external" }, { "id": "1.2.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.41", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0004458 D-lactate dehydrogenase (cytochrome) activity;GO:0008720 D-lactate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:1903457 lactate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P32891-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32892-1", "uniprot_id": [ { "id": "DRS1_YEAST", "url": "https://www.uniprot.org/uniprot/P32892", "type": "external" } ], "mass": 84843.0, "length": 752, "protein_name": "ATP-dependent RNA helicase DRS1", "gene_name": "DRS1", "organism": "Yeast", "refseq_name": "putative ATP-dependent RNA helicase", "refseq_ac": [ { "id": "NP_013093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013093", "type": "external" } ], "gene_names_uniprotkb": "DRS1; L1345", "gene_names_refseq": "DRS1", "protein_names_uniprotkb": "ATP-dependent RNA helicase DRS1; 3.6.4.13; Deficiency of ribosomal subunits protein 1", "protein_names_refseq": "putative ATP-dependent RNA helicase", "tax_id": 559292, "disease": "", "pathway": " (sce:YLL008W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11911362;1454790;14562095;15100437;17563356;18407956;19779198;20702584;21126336;23749301;24374639;33481703;33491328;8247005;8810043;9169871", "class_list": "", "function": "ATP-binding RNA helicase involved in ribosome assembly., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXZ4", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0006364 rRNA processing;GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P32892-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32893-1", "uniprot_id": [ { "id": "TRS65_YEAST", "url": "https://www.uniprot.org/uniprot/P32893", "type": "external" } ], "mass": 63368.0, "length": 560, "protein_name": "Trafficking protein particle complex II-specific subunit 65", "gene_name": "TRS65", "organism": "Yeast", "refseq_name": "Trs65p", "refseq_ac": [ { "id": "NP_011682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011682", "type": "external" } ], "gene_names_uniprotkb": "TRS65; KRE11", "gene_names_refseq": "KRE11; TRS65", "protein_names_uniprotkb": "Trafficking protein particle complex II-specific subunit 65; Beta-glucan synthesis-associated protein TRS65; Killer toxin-resistance protein 11; TRAPP II-specific subunit 65; Transport protein particle 65 kDa subunit", "protein_names_refseq": "Trs65p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR166W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "11239471;14562106;15665377;17330950;17475775;18407956;19684113;19779198;20702584;20972447;21126336;22218487;23749301;24374639;30516470;32597660;33481703;33491328;8462845;9169869;9290212;9564032", "class_list": "", "function": "Specific subunit of the TRAPP II complex, a highly conserved vesicle tethering complex that functions in the late Golgi as a guanine nucleotide exchanger (GEF) for the Golgi YPT1 GTPase. TRS65 plays a role in the YPT GEF activity of TRAPP II in concert with the two other TRAPP II-specific subunits TRS120 and TRS130. Involved in cell wall (1-->6)-beta-glucan synthesis., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUU9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005802 trans-Golgi network;GO:1990071 TRAPPII protein complex", "go_biological_process": "GO:0042147 retrograde transport, endosome to Golgi;GO:0006891 intra-Golgi vesicle-mediated transport;GO:0065003 protein-containing complex assembly;GO:0051274 beta-glucan biosynthetic process;GO:0071555 cell wall organization", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P32893-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32895-1", "uniprot_id": [ { "id": "KPR1_YEAST", "url": "https://www.uniprot.org/uniprot/P32895", "type": "external" } ], "mass": 47047.0, "length": 427, "protein_name": "Ribose-phosphate pyrophosphokinase 1", "gene_name": "PRS1", "organism": "Yeast", "refseq_name": "ribose phosphate diphosphokinase subunit PRS1", "refseq_ac": [ { "id": "NP_012740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012740", "type": "external" } ], "gene_names_uniprotkb": "PRS1; PPS1; PRP1; PRPS1; PRPS", "gene_names_refseq": "PRP1; PRS1", "protein_names_uniprotkb": "Ribose-phosphate pyrophosphokinase 1; 2.7.6.1; Phosphoribosyl pyrophosphate synthase 1", "protein_names_refseq": "ribose phosphate diphosphokinase subunit PRS1", "tax_id": 559292, "disease": "X-linked nonsyndromic deafness (Disease Ontology:DOID:0050566); Arts syndrome (Disease Ontology:DOID:0050647); Charcot-Marie-Tooth disease X-linked recessive 5 (Disease Ontology:DOID:0110210)", "pathway": " (sce:YKL181W); (R-SCE-73843)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10212224;14562095;14562106;15280369;17287358;18407956;19684113;19779198;19795423;19823750;20702584;21177495;23749301;24374639;32597660;33481703;33491328;7992503;8007970;8154185;8196765;9108276", "class_list": "", "function": "5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX20", "ec_number_list": [ { "id": "2.7.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.6.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0004749 ribose phosphate diphosphokinase activity", "go_cellular_component": "GO:0002189 ribose phosphate diphosphokinase complex;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0009156 ribonucleoside monophosphate biosynthetic process;GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process;GO:0006164 purine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P32895-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32897-1", "uniprot_id": [ { "id": "TIM23_YEAST", "url": "https://www.uniprot.org/uniprot/P32897", "type": "external" } ], "mass": 23244.0, "length": 222, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM23", "gene_name": "TIM23", "organism": "Yeast", "refseq_name": "protein transporter TIM23", "refseq_ac": [ { "id": "NP_014414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014414", "type": "external" } ], "gene_names_uniprotkb": "TIM23; MAS6; MIM23; MPI3; N3180", "gene_names_refseq": "MAS6; MIM23; MPI3; TIM23", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM23; Membrane import machinery protein MIM23; Mitochondrial protein import protein 3; Mitochondrial protein import protein MAS6", "protein_names_refseq": "protein transporter TIM23", "tax_id": 559292, "disease": "muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (sce:YNR017W); (R-SCE-1268020)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10830167;14562106;15797382;18418384;24374639;8050570;8354690;8370462;9169873", "class_list": "", "function": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1J2", "ec_number_list": [], "go_molecular_function": "GO:0008320 protein transmembrane transporter activity;GO:0030943 mitochondrion targeting sequence binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0045039 protein insertion into mitochondrial inner membrane;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P32897-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32898-1", "uniprot_id": [ { "id": "PREP_YEAST", "url": "https://www.uniprot.org/uniprot/P32898", "type": "external" } ], "mass": 112180.0, "length": 989, "protein_name": "Presequence protease, mitochondrial", "gene_name": "CYM1", "organism": "Yeast", "refseq_name": "pitrilysin family metalloprotease", "refseq_ac": [ { "id": "NP_010718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010718", "type": "external" } ], "gene_names_uniprotkb": "CYM1; D9461.18; MOP112", "gene_names_refseq": "CYM1; MOP112", "protein_names_uniprotkb": "Presequence protease, mitochondrial; 3.4.24.-; Metalloprotease of 112 kDa; Pitrilysin metalloproteinase; PreP; Protease M", "protein_names_refseq": "pitrilysin family metalloprotease", "tax_id": 559292, "disease": "hereditary ataxia (Disease Ontology:DOID:0050951); autosomal recessive spinocerebellar ataxia 30 (Disease Ontology:DOID:0070411); Alzheimer's disease (Disease Ontology:DOID:10652); primary cerebellar degeneration (Disease Ontology:DOID:9277)", "pathway": " (sce:YDR430C); (R-SCE-1268020)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "14562095;14562106;15606766;15772085;17330950;17563356;18407956;21621546;23749301;24374639;25176146;32597660;33481703;33491328;35997162;8224861;9169867", "class_list": "", "function": "Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running (PubMed:15772085, PubMed:25176146). Preferentially cleaves the N-terminal side of paired basic amino acid residues (PubMed:35997162). Also degrades other unstructured peptides (PubMed:25176146). May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase (PubMed:35997162)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VT59;Q04068", "ec_number_list": [ { "id": "2.1.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.3", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0004176 ATP-dependent peptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016485 protein processing;GO:0034982 mitochondrial protein processing;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P32898-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32899-1", "uniprot_id": [ { "id": "IMP3_YEAST", "url": "https://www.uniprot.org/uniprot/P32899", "type": "external" } ], "mass": 21885.0, "length": 183, "protein_name": "U3 small nucleolar ribonucleoprotein protein IMP3", "gene_name": "IMP3", "organism": "Yeast", "refseq_name": "snoRNA-binding rRNA-processing protein IMP3", "refseq_ac": [ { "id": "NP_012018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012018", "type": "external" } ], "gene_names_uniprotkb": "IMP3", "gene_names_refseq": "IMP3", "protein_names_uniprotkb": "U3 small nucleolar ribonucleoprotein protein IMP3; Interacting with MPP10 protein 3; U3 snoRNP protein IMP3", "protein_names_refseq": "snoRNA-binding rRNA-processing protein IMP3", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR148W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10409734;12068309;15489263;17322287;24374639;8091229;8358820", "class_list": "", "function": "Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL97", "ec_number_list": [], "go_molecular_function": "GO:0030515 snoRNA binding;GO:0019843 rRNA binding;GO:0140691 RNA folding chaperone", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030686 90S preribosome;GO:0034457 Mpp10 complex;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32899-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32900-1", "uniprot_id": [ { "id": "SKG6_YEAST", "url": "https://www.uniprot.org/uniprot/P32900", "type": "external" } ], "mass": 81849.0, "length": 734, "protein_name": "Protein SKG6", "gene_name": "SKG6", "organism": "Yeast", "refseq_name": "Skg6p", "refseq_ac": [ { "id": "NP_012019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012019", "type": "external" } ], "gene_names_uniprotkb": "SKG6", "gene_names_refseq": "SKG6", "protein_names_uniprotkb": "Protein SKG6; Suppressor of lethality of KEX2-GAS1 double null mutant 6", "protein_names_refseq": "Skg6p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR149C)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "11489916;14562106;14574415;15645486;15665377;16314687;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33229814;33481703;33491328;8091229;8358820", "class_list": "", "function": "May be involved in the polarity establishment process. Suppresses the lethality of KEX2-GAS1 double null mutant when overexpressed., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 46, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D3DL98", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0071944 cell periphery;GO:0000131 incipient cellular bud site;GO:0005934 cellular bud tip;GO:0005935 cellular bud neck", "go_biological_process": "GO:1902413 negative regulation of mitotic cytokinesis", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P32900-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32901-1", "uniprot_id": [ { "id": "PTR2_YEAST", "url": "https://www.uniprot.org/uniprot/P32901", "type": "external" } ], "mass": 68044.0, "length": 601, "protein_name": "Peptide transporter PTR2", "gene_name": "PTR2", "organism": "Yeast", "refseq_name": "Ptr2p", "refseq_ac": [ { "id": "NP_013019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013019", "type": "external" } ], "gene_names_uniprotkb": "PTR2; YKR413", "gene_names_refseq": "PTR2", "protein_names_uniprotkb": "Peptide transporter PTR2; Peptide permease PTR2", "protein_names_refseq": "Ptr2p", "tax_id": 559292, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YKR093W); (R-SCE-427975)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "11875433;16847258;17330950;18407956;19779198;19795423;19823750;20702584;21177495;22218487;23749301;24374639;32597660;33481703;33491328;8154186;8196765;8264579", "class_list": "", "function": "Uptake of small peptides., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VXF3", "ec_number_list": [], "go_molecular_function": "GO:0042937 tripeptide transmembrane transporter activity;GO:1904680 peptide transmembrane transporter activity;GO:0071916 dipeptide transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0015031 protein transport;GO:0015833 peptide transport;GO:0140206 dipeptide import across plasma membrane;GO:0042938 dipeptide transport;GO:0042939 tripeptide transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P32901-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32905-1", "uniprot_id": [ { "id": "RSSA1_YEAST", "url": "https://www.uniprot.org/uniprot/P32905", "type": "external" } ], "mass": 28024.0, "length": 252, "protein_name": "Small ribosomal subunit protein uS2A", "gene_name": "RPS0A", "organism": "Yeast", "refseq_name": "40S ribosomal protein uS2 RPS0A", "refseq_ac": [ { "id": "NP_011730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011730", "type": "external" } ], "gene_names_uniprotkb": "RPS0A; NAB1A; NAB1; YST1", "gene_names_refseq": "NAB1A; NAB1; RPS0A; YST1", "protein_names_uniprotkb": "Small ribosomal subunit protein uS2A; 40S ribosomal protein S0-A; Nucleic acid-binding protein NAB1A", "protein_names_refseq": "40S ribosomal protein uS2 RPS0A", "tax_id": 559292, "disease": "arrhythmogenic right ventricular dysplasia 5 (Disease Ontology:DOID:0110074); sciatic neuropathy (Disease Ontology:DOID:11446); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (sce:YGR214W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 12, "publication_count": 25, "publication_id_list": "10601260;11701127;14562095;14562106;14627813;14976550;15665377;18407956;19779198;21109664;22096102;23749301;24374639;24524803;33481703;33491328;7895733;8626693;9038161;9169869;9290212;9298649;9559554;9718729;9973221", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uS2 is required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits (PubMed:14627813, PubMed:9973221)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUZ7", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule;GO:0030686 90S preribosome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0000054 ribosomal subunit export from nucleus;GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0002181 cytoplasmic translation;GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P32905-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32911-1", "uniprot_id": [ { "id": "SUI1_YEAST", "url": "https://www.uniprot.org/uniprot/P32911", "type": "external" } ], "mass": 12312.0, "length": 108, "protein_name": "Eukaryotic translation initiation factor eIF-1", "gene_name": "SUI1", "organism": "Yeast", "refseq_name": "translation initiation factor eIF1", "refseq_ac": [ { "id": "NP_014155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014155", "type": "external" } ], "gene_names_uniprotkb": "SUI1; N0905; RFR1", "gene_names_refseq": "MOF2; RFR1; SUI1", "protein_names_uniprotkb": "Eukaryotic translation initiation factor eIF-1; Protein translation factor SUI1", "protein_names_refseq": "translation initiation factor eIF1", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL244C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "15665377;1729602;17563356;18407956;19795423;19823750;22218487;22814378;24374639;32027465;33481703;33491328;9169873;9234673;9671501", "class_list": "", "function": "Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0U9", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0043024 ribosomal small subunit binding;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0016282 eukaryotic 43S preinitiation complex;GO:0043614 multi-eIF complex", "go_biological_process": "GO:0006417 regulation of translation;GO:1990145 maintenance of translational fidelity;GO:0001731 formation of translation preinitiation complex;GO:0006450 regulation of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P32911-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32913-1", "uniprot_id": [ { "id": "VPS17_YEAST", "url": "https://www.uniprot.org/uniprot/P32913", "type": "external" } ], "mass": 63204.0, "length": 551, "protein_name": "Vacuolar protein sorting-associated protein 17", "gene_name": "VPS17", "organism": "Yeast", "refseq_name": "retromer subunit VPS17", "refseq_ac": [ { "id": "NP_014775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014775", "type": "external" } ], "gene_names_uniprotkb": "VPS17; O3314; PEP21; VPT3; YOR3314W", "gene_names_refseq": "PEP21; VPS17; VPT3", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 17; Carboxypeptidase Y-deficient protein 21; Vacuolar protein targeting protein 3", "protein_names_refseq": "retromer subunit VPS17", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR132W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "12181349;14562106;17563356;18407956;19779198;23749301;24374639;3062374;33229814;33481703;33491328;34965436;3538017;35506766;35574911;8416961;8904341;9169874;9200815;9285823;9700157", "class_list": "", "function": "Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport (PubMed:12181349, PubMed:9700157). The VPS5-VPS17 subcomplex may assemble onto the membrane to promote vesicle formation and is required for recycling the vacuolar protein-sorting receptor (PubMed:9285823, PubMed:9700157). Required for the sorting and delivery of a subset of soluble vacuolar hydrolases (PubMed:3062374, PubMed:3538017, PubMed:8416961). Required for retention of late Golgi membrane proteins and vacuolar biogenesis (PubMed:9700157). Involved in vacuolar fragmentation during hyperosmotic stress (PubMed:35574911)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6W2J0;Q12279", "ec_number_list": [], "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0012505 endomembrane system;GO:0030904 retromer complex;GO:0030905 retromer, tubulation complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P32913-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32939-1", "uniprot_id": [ { "id": "YPT7_YEAST", "url": "https://www.uniprot.org/uniprot/P32939", "type": "external" } ], "mass": 23043.0, "length": 208, "protein_name": "Ypt/Rab-type GTPase YPT7", "gene_name": "YPT7", "organism": "Yeast", "refseq_name": "Rab family GTPase YPT7", "refseq_ac": [ { "id": "NP_013713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013713", "type": "external" } ], "gene_names_uniprotkb": "YPT7; VAM4; YM8270.02", "gene_names_refseq": "AST4; VAM4; YPT7", "protein_names_uniprotkb": "Ypt/Rab-type GTPase YPT7; Vacuolar morphology protein 4; Ypt7p", "protein_names_refseq": "Rab family GTPase YPT7", "tax_id": 559292, "disease": "Charcot-Marie-Tooth disease type 2 (Disease Ontology:DOID:0050539); Charcot-Marie-Tooth disease type 2B (Disease Ontology:DOID:0110159); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YML001W); (R-SCE-6798695); (R-SCE-8854214); (R-SCE-8873719); (R-SCE-8876198); (R-SCE-9013406)", "pathway_count": 6, "publication_count": 30, "publication_id_list": "10725336;10944212;11062257;11118206;11210571;11590240;11785952;11937061;11943201;12553664;14562106;1473149;1526998;19386605;19779198;20797862;21062894;21126336;22106047;22593205;23749301;24374639;25026035;26178622;33481703;33491328;37463208;7489715;8308065;9169872", "class_list": "", "function": "Ypt/Rab-type GTPases are key regulators of membrane trafficking and intracellular vesicular transport. They act as molecular switches that convert between GTP-bound and GDP-bound states, and regulate virtually all steps of membrane traffic from the formation of the transport vesicle at the donor membrane to its fusion at the target membrane. In the GDP-bound state, Ypt proteins are predominantly cytosolic, solubilized through the interaction with a GDP dissociation inhibitor (GDI). In the GTP-bound state, the proteins are membrane bound and interact with specific effector proteins that select cargo, promote vesicle movement, or verify the correct site of fusion (Probable). Involved in regulation of vesicular protein transport in exo- and endocytosis (PubMed:8308065). Involved in regulation of late endosome to vacuole trafficking and homotypic vacuole fusion, by interacting in its GTP-bound state on the donor membrane with the large multiprotein HOPS/class C-Vps tethering complex on the acceptor membrane (PubMed:10725336, PubMed:10944212, PubMed:11062257, PubMed:11118206, PubMed:11210571, PubMed:11590240, PubMed:19386605, PubMed:21062894, PubMed:7489715, PubMed:8308065). Involved in retromer assembly and cargo export, recognizing the cargo selection complex (CSC). GTP-bound YPT7 recruits CSC to vacuolar membranes via retromer subunit VPS35 (PubMed:22593205). Interacts with the HOPS complex subunit VPS39 independent of the HOPS complex at mitochondria-vacuole contact sites (vCLAMPs), providing a physical and metabolic interconnection between the endocytic pathway and mitochondria (PubMed:25026035)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZH4", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0005770 late endosome;GO:0045335 phagocytic vesicle", "go_biological_process": "GO:0006897 endocytosis;GO:0016236 macroautophagy;GO:0016192 vesicle-mediated transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0043254 regulation of protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P32939-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32945-1", "uniprot_id": [ { "id": "PPQ1_YEAST", "url": "https://www.uniprot.org/uniprot/P32945", "type": "external" } ], "mass": 61420.0, "length": 549, "protein_name": "Serine/threonine-protein phosphatase PPQ", "gene_name": "PPQ1", "organism": "Yeast", "refseq_name": "protein-serine/threonine phosphatase", "refseq_ac": [ { "id": "NP_015146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015146", "type": "external" } ], "gene_names_uniprotkb": "PPQ1; SAL6", "gene_names_refseq": "PPQ1; SAL6", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase PPQ; 3.1.3.16", "protein_names_refseq": "protein-serine/threonine phosphatase", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL179W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "1321058;14562106;15665377;18407956;19779198;19795423;19823750;20489023;21126336;23749301;24374639;27821475;32597660;33481703;33491328;7851758;8269960;9169875", "class_list": "", "function": "Phosphatase involved in the regulation of protein synthesis. Affects translational accuracy., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3I9", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.43", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007059 chromosome segregation;GO:0007346 regulation of mitotic cell cycle;GO:0090029 negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P32945-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33296-1", "uniprot_id": [ { "id": "UBC6_YEAST", "url": "https://www.uniprot.org/uniprot/P33296", "type": "external" } ], "mass": 28383.0, "length": 250, "protein_name": "Ubiquitin-conjugating enzyme E2 6", "gene_name": "UBC6", "organism": "Yeast", "refseq_name": "E2 ubiquitin-conjugating protein UBC6", "refseq_ac": [ { "id": "NP_011026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011026", "type": "external" } ], "gene_names_uniprotkb": "UBC6; DOA2", "gene_names_refseq": "DOA2; UBC6", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 6; 2.3.2.23; E2 ubiquitin-conjugating enzyme 6; Ubiquitin carrier protein UBC6; Ubiquitin-protein ligase UBC6", "protein_names_refseq": "E2 ubiquitin-conjugating protein UBC6", "tax_id": 559292, "disease": "", "pathway": " (sce:YER100W); (R-SCE-9609523); (R-SCE-983168)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "11641273;14562106;16179953;17330950;17563356;18407956;19779198;20702584;23749301;24374639;32597660;33481703;33491328;8393731;8396728;9169868;9695950", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM07", "ec_number_list": [ { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "1.14.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.64", "type": "external" }, { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0036503 ERAD pathway;GO:0006513 protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P33296-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33297-1", "uniprot_id": [ { "id": "PRS6A_YEAST", "url": "https://www.uniprot.org/uniprot/P33297", "type": "external" } ], "mass": 48256.0, "length": 434, "protein_name": "26S proteasome regulatory subunit 6A", "gene_name": "RPT5", "organism": "Yeast", "refseq_name": "proteasome regulatory particle base subunit RPT5", "refseq_ac": [ { "id": "NP_014760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014760", "type": "external" } ], "gene_names_uniprotkb": "RPT5; O3258; YOR3258W; YTA1", "gene_names_refseq": "RPT5; YTA1", "protein_names_uniprotkb": "26S proteasome regulatory subunit 6A; TBP-1; Tat-binding protein homolog 1", "protein_names_refseq": "proteasome regulatory particle base subunit RPT5", "tax_id": 559292, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YOR117W); (R-SCE-1236978); (R-SCE-5668541); (R-SCE-5689880); (R-SCE-6798695); (R-SCE-9907900)", "pathway_count": 6, "publication_count": 15, "publication_id_list": "12504901;17563356;18407956;19779198;20486117;22814378;22927375;23749301;24374639;33481703;33491328;7754704;8904341;9169874;9200815", "class_list": "", "function": "The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2H6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0036402 proteasome-activating activity", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070682 proteasome regulatory particle assembly;GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P33297-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33298-1", "uniprot_id": [ { "id": "PRS6B_YEAST", "url": "https://www.uniprot.org/uniprot/P33298", "type": "external" } ], "mass": 47894.0, "length": 428, "protein_name": "26S proteasome regulatory subunit 6B homolog", "gene_name": "RPT3", "organism": "Yeast", "refseq_name": "proteasome regulatory particle base subunit RPT3", "refseq_ac": [ { "id": "NP_010682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010682", "type": "external" } ], "gene_names_uniprotkb": "RPT3; D9509.14; YNT1; YTA2", "gene_names_refseq": "RPT3; YNT1; YTA2", "protein_names_uniprotkb": "26S proteasome regulatory subunit 6B homolog; Protein YNT1; Tat-binding homolog 2", "protein_names_refseq": "proteasome regulatory particle base subunit RPT3", "tax_id": 559292, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); hereditary spastic paraplegia (Disease Ontology:DOID:2476); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (sce:YDR394W); (R-SCE-1236978); (R-SCE-5668541); (R-SCE-5689880); (R-SCE-9907900)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "12504901;15665377;18407956;19795423;19823750;20486117;21126336;22106047;22218487;22927375;24374639;32597660;33481703;33491328;7754704;7803857;9169867", "class_list": "", "function": "The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT28", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0036402 proteasome-activating activity", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070682 proteasome regulatory particle assembly;GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P33298-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33300-1", "uniprot_id": [ { "id": "SUR1_YEAST", "url": "https://www.uniprot.org/uniprot/P33300", "type": "external" } ], "mass": 44808.0, "length": 382, "protein_name": "Mannosyl phosphorylinositol ceramide synthase SUR1", "gene_name": "SUR1", "organism": "Yeast", "refseq_name": "mannosylinositol phosphorylceramide synthase catalytic subunit SUR1", "refseq_ac": [ { "id": "NP_015268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015268", "type": "external" } ], "gene_names_uniprotkb": "SUR1; BCL21; CSG1; LPE15", "gene_names_refseq": "BCL21; CSG1; LPE15; SUR1", "protein_names_uniprotkb": "Mannosyl phosphorylinositol ceramide synthase SUR1; 2.4.1.370", "protein_names_refseq": "mannosylinositol phosphorylceramide synthase catalytic subunit SUR1", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL057C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "12954640;16847258;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21177495;23749301;24374639;32597660;33481703;33491328;35713525;7854312;8488727;9169875;9323360", "class_list": "glycogene;glycosyltransferase", "function": "Involved in the synthesis of mannosyl phosphorylinositol ceramide (PubMed:12954640, PubMed:9323360). Catalyzes the addition of mannosyl to phosphorylinositol ceramide. Suppressor of RVS161 mutation (PubMed:12954640, PubMed:9323360)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W3V7", "ec_number_list": [ { "id": "2.4.1.370", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.370", "type": "external" } ], "go_molecular_function": "GO:0000030 mannosyltransferase activity;GO:0103064 inositol phosphorylceramide mannosyltransferase activity", "go_cellular_component": "GO:0031501 mannosyltransferase complex;GO:0005794 Golgi apparatus;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0006675 mannosyl-inositol phosphorylceramide metabolic process;GO:0006676 mannosyl diphosphorylinositol ceramide metabolic process;GO:0051999 mannosyl-inositol phosphorylceramide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P33300-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000100000001.010.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33301-1", "uniprot_id": [ { "id": "XRS2_YEAST", "url": "https://www.uniprot.org/uniprot/P33301", "type": "external" } ], "mass": 96365.0, "length": 854, "protein_name": "DNA repair protein XRS2", "gene_name": "XRS2", "organism": "Yeast", "refseq_name": "Xrs2p", "refseq_ac": [ { "id": "NP_010657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010657", "type": "external" } ], "gene_names_uniprotkb": "XRS2; D9481.13", "gene_names_refseq": "XRS2", "protein_names_uniprotkb": "DNA repair protein XRS2", "protein_names_refseq": "Xrs2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR369C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "14522986;14562106;1468624;17563356;18407956;19779198;21126336;21177495;23749301;24374639;27017623;31537797;32597660;33481703;33491328;35501303;8164689;9169867;9845372", "class_list": "", "function": "Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:14522986, PubMed:1468624, PubMed:35501303). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:35501303). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (By similarity). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (By similarity). Within the MRN complex, XRS2 acts as a protein-protein adapter (PubMed:14522986). Specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (By similarity). Recruits MRE11 and RAD50 components of the MRN complex to DNA damage sites in response to DNA damage (PubMed:14522986). The MRN complex is also required for the processing of R-loops (PubMed:31537797)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT00", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042162 telomeric DNA binding;GO:0003691 double-stranded telomeric DNA binding;GO:0051880 G-quadruplex DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000781 chromosome, telomeric region;GO:0030870 Mre11 complex", "go_biological_process": "GO:0006284 base-excision repair;GO:0000723 telomere maintenance;GO:0006302 double-strand break repair;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0042138 meiotic DNA double-strand break formation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P33301-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33302-1", "uniprot_id": [ { "id": "PDR5_YEAST", "url": "https://www.uniprot.org/uniprot/P33302", "type": "external" } ], "mass": 170438.0, "length": 1511, "protein_name": "Pleiotropic ABC efflux transporter of multiple drugs", "gene_name": "PDR5", "organism": "Yeast", "refseq_name": "ATP-binding cassette multidrug transporter PDR5", "refseq_ac": [ { "id": "NP_014796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014796", "type": "external" } ], "gene_names_uniprotkb": "PDR5; LEM1; STS1; YDR1", "gene_names_refseq": "LEM1; PDR5; STS1; YDR1", "protein_names_uniprotkb": "Pleiotropic ABC efflux transporter of multiple drugs; Pleiotropic drug resistance protein 5; Suppressor of toxicity of sporidesmin", "protein_names_refseq": "ATP-binding cassette multidrug transporter PDR5", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR153W)", "pathway_count": 1, "publication_count": 90, "publication_id_list": "10601275;10602734;10639374;10712705;10734226;10841772;11321575;11327879;11422371;11515543;11602584;11758940;11875433;11882665;11943786;12469340;12496287;12529331;12551908;12754197;12872131;12896805;1319843;13678835;14557538;14562106;14599467;14960317;15009193;15047528;15294907;15707993;15713640;15796929;15836770;15896930;16008355;16061415;16141212;16487346;16751665;16847258;17156010;17158869;17287358;17302805;17316560;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;31757931;32597660;3316228;33481703;33491328;7565740;7623800;7753868;7840595;7882421;8007969;8175692;8294477;8307980;8549828;8663352;8810273;8821655;8940170;8985171;9020838;9046089;9115278;9169874;9393437;9393438;9450972;9559778;9818966;9830032", "class_list": "", "function": "Active efflux of weakly charged organic compounds of 90 cubic Angstroms to 300 cubic Angstroms surface volume. Confers resistance to numerous chemicals including cycloheximide, sulfomethuron methyl, steroids, antiseptics, antibiotics, anticancer, herbicides, mycotoxins, insecticides, ionophores, alkaloids, flavonoids, phenothiazines, organotin compounds, carbazoles, lysosomotropic aminoesters, detergents, rhodamines and other fluorophores, azoles and other antifungals. Exhibits nucleoside triphosphatase activity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 34, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W2L0", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0046677 response to antibiotic;GO:0009410 response to xenobiotic stimulus;GO:0030003 intracellular monoatomic cation homeostasis;GO:0046898 response to cycloheximide;GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane", "synthesized_glycan_count": 0, "hit_score": 9.1, "record_id": "P33302-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33307-1", "uniprot_id": [ { "id": "CSE1_YEAST", "url": "https://www.uniprot.org/uniprot/P33307", "type": "external" } ], "mass": 109356.0, "length": 960, "protein_name": "Importin alpha re-exporter", "gene_name": "CSE1", "organism": "Yeast", "refseq_name": "importin-alpha export receptor", "refseq_ac": [ { "id": "NP_011276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011276", "type": "external" } ], "gene_names_uniprotkb": "CSE1; HRC135", "gene_names_refseq": "CSE1; KAP109", "protein_names_uniprotkb": "Importin alpha re-exporter; Chromosome segregation protein CSE1", "protein_names_refseq": "importin-alpha export receptor", "tax_id": 559292, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (sce:YGL238W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10394916;14562106;15602554;18407956;21177495;24374639;33491328;33502312;8336709;8750240;9169869;9744791;9774694;9857050", "class_list": "", "function": "Export receptor for importin alpha (SRP1). Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV96", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0005049 nuclear export signal receptor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0061015 snRNA import into nucleus;GO:0051301 cell division;GO:0046827 positive regulation of protein export from nucleus;GO:0006611 protein export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P33307-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33308-1", "uniprot_id": [ { "id": "MED9_YEAST", "url": "https://www.uniprot.org/uniprot/P33308", "type": "external" } ], "mass": 17376.0, "length": 149, "protein_name": "Mediator of RNA polymerase II transcription subunit 9", "gene_name": "CSE2", "organism": "Yeast", "refseq_name": "Cse2p", "refseq_ac": [ { "id": "NP_014407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014407", "type": "external" } ], "gene_names_uniprotkb": "CSE2; MED9; N2046", "gene_names_refseq": "CSE2; MED9", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 9; Chromosome segregation protein 2; Mediator complex subunit 9", "protein_names_refseq": "Cse2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNR010W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11555651;12191485;14562095;14562106;15175151;15477388;16002404;16076843;16109375;16263706;17192271;17322287;19779198;24374639;33481703;33491328;7900425;8336709;9169873;9812975", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1I5", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P33308-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33310-1", "uniprot_id": [ { "id": "MDL1_YEAST", "url": "https://www.uniprot.org/uniprot/P33310", "type": "external" } ], "mass": 75950.0, "length": 695, "protein_name": "ATP-dependent permease MDL1, mitochondrial", "gene_name": "MDL1", "organism": "Yeast", "refseq_name": "ATP-binding cassette permease MDL1", "refseq_ac": [ { "id": "NP_013289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013289", "type": "external" } ], "gene_names_uniprotkb": "MDL1; L9470.3", "gene_names_refseq": "MDL1", "protein_names_uniprotkb": "ATP-dependent permease MDL1, mitochondrial; ABC transporter MDL1; Multidrug resistance-like protein 1", "protein_names_refseq": "ATP-binding cassette permease MDL1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR188W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11251115;14562095;14562106;14576278;24374639;33481703;7912468;9169871", "class_list": "", "function": "Mediates export of peptides with molecular masses of 2100 to 600 daltons generated upon proteolysis of mitochondrial inner membrane proteins., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYJ1", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0015421 ABC-type oligopeptide transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0090374 oligopeptide export from mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P33310-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33314-1", "uniprot_id": [ { "id": "BUD2_YEAST", "url": "https://www.uniprot.org/uniprot/P33314", "type": "external" } ], "mass": 126663.0, "length": 1104, "protein_name": "Inhibitory regulator protein BUD2/CLA2", "gene_name": "BUD2", "organism": "Yeast", "refseq_name": "GTPase-activating protein BUD2", "refseq_ac": [ { "id": "NP_012831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012831", "type": "external" } ], "gene_names_uniprotkb": "BUD2; CLA2; ERC25; YKL424", "gene_names_refseq": "BUD2; CLA2; ERC25", "protein_names_uniprotkb": "Inhibitory regulator protein BUD2/CLA2; Bud site selection protein 2", "protein_names_refseq": "GTPase-activating protein BUD2", "tax_id": 559292, "disease": "peripheral artery disease (Disease Ontology:DOID:0050830); autosomal dominant intellectual developmental disorder 5 (Disease Ontology:DOID:0070035); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); neurodegenerative disease (Disease Ontology:DOID:1289); lung cancer (Disease Ontology:DOID:1324); alcohol use disorder (Disease Ontology:DOID:1574); atherosclerosis (Disease Ontology:DOID:1936); coronary artery disease (Disease Ontology:DOID:3393); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); pulmonary embolism (Disease Ontology:DOID:9477)", "pathway": " (sce:YKL092C); (R-SCE-9696273)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "14562106;17330950;17563356;18407956;19779198;19795423;19823750;20702584;22814378;23749301;24374639;32597660;33229814;33481703;33491328;34502421;34965436;8196765;8203166;8262070;8371782", "class_list": "", "function": "Stimulates the GTPase activity of BUD1/RSR1. Participates in the regulation of bud-site selection., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VXJ6", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000131 incipient cellular bud site;GO:0005628 prospore membrane;GO:0005935 cellular bud neck", "go_biological_process": "GO:1902531 regulation of intracellular signal transduction;GO:0007163 establishment or maintenance of cell polarity;GO:0001403 invasive growth in response to glucose limitation;GO:0007120 axial cellular bud site selection;GO:0007121 bipolar cellular bud site selection", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P33314-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33317-1", "uniprot_id": [ { "id": "DUT_YEAST", "url": "https://www.uniprot.org/uniprot/P33317", "type": "external" } ], "mass": 15307.0, "length": 147, "protein_name": "Deoxyuridine 5'-triphosphate nucleotidohydrolase", "gene_name": "DUT1", "organism": "Yeast", "refseq_name": "bifunctional dITP/dUTP diphosphatase", "refseq_ac": [ { "id": "NP_009811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009811", "type": "external" } ], "gene_names_uniprotkb": "DUT1; YBR1705", "gene_names_refseq": "DUT1", "protein_names_uniprotkb": "Deoxyuridine 5'-triphosphate nucleotidohydrolase; 3.6.1.23; dUTP pyrophosphatase; dUTPase", "protein_names_refseq": "bifunctional dITP/dUTP diphosphatase", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YBR252W); (R-SCE-499943)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "14562106;17322287;17563356;18407956;21177495;21548881;22814378;23749301;24374639;32597660;33481703;33491328;7813418;8223452;8256522", "class_list": "", "function": "Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (PubMed:21548881, PubMed:8223452). Shows a significant activity against dITP, another potentially mutagenic nucleotide (PubMed:21548881)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQP8", "ec_number_list": [ { "id": "3.6.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.23", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004170 dUTP diphosphatase activity;GO:0035870 dITP diphosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006226 dUMP biosynthetic process;GO:0046081 dUTP catabolic process;GO:0035863 dITP catabolic process;GO:0009213 pyrimidine deoxyribonucleoside triphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P33317-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33322-1", "uniprot_id": [ { "id": "CBF5_YEAST", "url": "https://www.uniprot.org/uniprot/P33322", "type": "external" } ], "mass": 54705.0, "length": 483, "protein_name": "H/ACA ribonucleoprotein complex subunit CBF5", "gene_name": "CBF5", "organism": "Yeast", "refseq_name": "pseudouridine synthase CBF5", "refseq_ac": [ { "id": "NP_013276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013276", "type": "external" } ], "gene_names_uniprotkb": "CBF5; L9470.11", "gene_names_refseq": "CBF5", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit CBF5; 5.4.99.-; Centromere-binding factor 5; Centromere/microtubule-binding protein CBF5; H/ACA snoRNP protein CBF5; Small nucleolar RNP protein CBF5; p64'", "protein_names_refseq": "pseudouridine synthase CBF5", "tax_id": 559292, "disease": "X-linked dyskeratosis congenita (Disease Ontology:DOID:0070025); aplastic anemia (Disease Ontology:DOID:12449); dyskeratosis congenita (Disease Ontology:DOID:2729)", "pathway": " (sce:YLR175W); (R-SCE-171319)", "pathway_count": 2, "publication_count": 37, "publication_id_list": "10523634;11983179;12228251;12515383;14562095;14562106;14690591;15388873;15686447;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20190278;20702584;21126336;21131909;21177495;22106047;22218487;23749301;24374639;24909858;25219674;32597660;33481703;33491328;33502312;8336724;9169871;9315678;9472021;9848653", "class_list": "", "function": "Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:10523634, PubMed:9315678, PubMed:9472021, PubMed:9848653). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:10523634, PubMed:9315678, PubMed:9472021, PubMed:9848653). Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing (PubMed:10523634, PubMed:9315678, PubMed:9472021, PubMed:9848653). The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs (PubMed:21131909, PubMed:25219674). Catalyzes pseudouridylation at position 93 in U2 snRNA (PubMed:21131909). Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs (PubMed:25219674). It is a centromeric DNA-CBF3-binding factor which is involved in mitotic chromosome segregation (PubMed:8336724). Essential for cell growth (PubMed:8336724)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYH9", "ec_number_list": [ { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" }, { "id": "5.4.99.25", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.25", "type": "external" }, { "id": "5.4.99.27", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.27", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0009982 pseudouridine synthase activity;GO:0106032 snRNA pseudouridine synthase activity", "go_cellular_component": "GO:0005874 microtubule;GO:0000775 chromosome, centromeric region;GO:0031429 box H/ACA snoRNP complex;GO:0030686 90S preribosome", "go_biological_process": "GO:0000154 rRNA modification;GO:0051301 cell division;GO:0006364 rRNA processing;GO:0000495 box H/ACA sno(s)RNA 3'-end processing;GO:0031118 rRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P33322-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33327-1", "uniprot_id": [ { "id": "DHE2_YEAST", "url": "https://www.uniprot.org/uniprot/P33327", "type": "external" } ], "mass": 124332.0, "length": 1092, "protein_name": "NAD-specific glutamate dehydrogenase", "gene_name": "GDH2", "organism": "Yeast", "refseq_name": "glutamate dehydrogenase (NAD(+))", "refseq_ac": [ { "id": "NP_010066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010066", "type": "external" } ], "gene_names_uniprotkb": "GDH2; D0892", "gene_names_refseq": "GDH2", "protein_names_uniprotkb": "NAD-specific glutamate dehydrogenase; 1.4.1.2; NAD-GDH", "protein_names_refseq": "glutamate dehydrogenase (NAD(+))", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL215C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562106;15665377;1682801;18407956;20489023;20702584;21126336;22814378;23749301;24374639;32597660;33491328;33502312;7901008;9169867", "class_list": "", "function": "NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRD9", "ec_number_list": [ { "id": "1.4.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.2", "type": "external" } ], "go_molecular_function": "GO:0004352 glutamate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006066 alcohol metabolic process;GO:0006538 L-glutamate catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P33327-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33328-1", "uniprot_id": [ { "id": "SNC2_YEAST", "url": "https://www.uniprot.org/uniprot/P33328", "type": "external" } ], "mass": 12957.0, "length": 115, "protein_name": "Synaptobrevin homolog 2", "gene_name": "SNC2", "organism": "Yeast", "refseq_name": "SNAP receptor SNC2", "refseq_ac": [ { "id": "NP_014972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014972", "type": "external" } ], "gene_names_uniprotkb": "SNC2", "gene_names_refseq": "SNC2", "protein_names_uniprotkb": "Synaptobrevin homolog 2", "protein_names_refseq": "SNAP receptor SNC2", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR327C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12872131;14562106;15973437;16751107;17287358;18407956;19779198;22106047;23749301;24374639;33481703;33491328;8374953;8896263;9169874", "class_list": "", "function": "SNC1 and SNC2 are vesicle-targeting proteins essential for normal secretory traffic between the Golgi and the plasma membrane. They may also be involved in vesicle fusion., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W324", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030658 transport vesicle membrane", "go_biological_process": "GO:0048210 Golgi vesicle fusion to target membrane;GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0042147 retrograde transport, endosome to Golgi;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P33328-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33333-1", "uniprot_id": [ { "id": "PLSC_YEAST", "url": "https://www.uniprot.org/uniprot/P33333", "type": "external" } ], "mass": 33887.0, "length": 303, "protein_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase", "gene_name": "SLC1", "organism": "Yeast", "refseq_name": "1-acylglycerol-3-phosphate O-acyltransferase SLC1", "refseq_ac": [ { "id": "NP_010231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010231", "type": "external" } ], "gene_names_uniprotkb": "SLC1", "gene_names_refseq": "SLC1", "protein_names_uniprotkb": "1-acyl-sn-glycerol-3-phosphate acyltransferase; 1-AGP acyltransferase; 1-AGPAT; 2.3.1.23; 2.3.1.51; 2.3.1.n7; LPAAT; Lysophosphatidic acid acyltransferase; Sphingolipid compensation protein 1", "protein_names_refseq": "1-acylglycerol-3-phosphate O-acyltransferase SLC1", "tax_id": 559292, "disease": "congenital generalized lipodystrophy type 1 (Disease Ontology:DOID:0111135); lipodystrophy (Disease Ontology:DOID:811)", "pathway": " (sce:YDL052C); (R-SCE-1483166); (R-SCE-6798695)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "17322287;17675291;17890783;18154737;19779198;20694142;21820081;24374639;24868093;26643989;33491328;8408076;9169867;9401016", "class_list": "", "function": "Acyltransferase that catalyzes the sn-2-specific, acyl-CoA-dependent acylation of lysophosphatidic acid (LPA) to phosphatidic acid (PA) in lipid particles (PubMed:9401016). Together with ALE1, plays a central role in PA biosynthesis. PA is the intermediate, from which all glycerophospholipids are synthesized (PubMed:17890783). Can also acylate lysophosphoinositol (LPI) and lysophosphoserine (LPS) (PubMed:17675291). The fatty acyl substrates include 18:1-acyl-CoA, 14:0-acyl-CoA, 12:0-acyl-CoA and 10:0-acyl-CoA (PubMed:20694142)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRU4;E9P8Y5", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.3.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.64", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0106262 1-acylglycerophosphoethanolamine O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0016020 membrane", "go_biological_process": "GO:0006654 phosphatidic acid biosynthetic process;GO:0046474 glycerophospholipid biosynthetic process;GO:0016024 CDP-diacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P33333-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33334-1", "uniprot_id": [ { "id": "PRP8_YEAST", "url": "https://www.uniprot.org/uniprot/P33334", "type": "external" } ], "mass": 279504.0, "length": 2413, "protein_name": "Pre-mRNA-splicing factor 8", "gene_name": "PRP8", "organism": "Yeast", "refseq_name": "U4/U6-U5 snRNP complex subunit PRP8", "refseq_ac": [ { "id": "NP_012035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012035", "type": "external" } ], "gene_names_uniprotkb": "PRP8; DBF3; DNA39; RNA8; SLT21; USA2", "gene_names_refseq": "DBF3; DNA39; PRP8; RNA8; SLT21; USA2", "protein_names_uniprotkb": "Pre-mRNA-splicing factor 8", "protein_names_refseq": "U4/U6-U5 snRNP complex subunit PRP8", "tax_id": 559292, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); retinitis pigmentosa 13 (Disease Ontology:DOID:0110403); prostate cancer (Disease Ontology:DOID:10283); retinitis pigmentosa (Disease Ontology:DOID:10584); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (sce:YHR165C)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10444596;10449419;11425851;11884590;12773561;14562106;14690591;17317632;17934474;18407956;18779563;18836455;18843295;18953335;19098916;19854871;21764848;23354046;24374639;2835658;33229814;33491328;7785334;7838707;8091229;9150140", "class_list": "", "function": "Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for association of BRR2 with the spliceosomal U5 snRNP, and the subsequent assembly of the U4/U6-U5 tri-snRNP complex. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site, as well as the branch region. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. Also has a role in cell cycle., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D3DLB4", "ec_number_list": [], "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0030620 U2 snRNA binding;GO:0003729 mRNA binding;GO:0008237 metallopeptidase activity;GO:0030619 U1 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071013 catalytic step 2 spliceosome;GO:0005682 U5 snRNP;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0000350 generation of catalytic spliceosome for second transesterification step;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P33334-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33338-1", "uniprot_id": [ { "id": "SLA2_YEAST", "url": "https://www.uniprot.org/uniprot/P33338", "type": "external" } ], "mass": 108911.0, "length": 968, "protein_name": "Protein SLA2", "gene_name": "SLA2", "organism": "Yeast", "refseq_name": "Sla2p", "refseq_ac": [ { "id": "NP_014156", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014156", "type": "external" } ], "gene_names_uniprotkb": "SLA2; END4; MOP2; N1102; UFG1", "gene_names_refseq": "END4; MOP2; SLA2", "protein_names_uniprotkb": "Protein SLA2; Transmembrane protein MOP2", "protein_names_refseq": "Sla2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL243W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11875433;14562106;15665377;17330950;17563356;18407956;19684113;19779198;20702584;21177495;22218487;23749301;24374639;32597660;33481703;33491328;7896828;8335689;8896273;9169873", "class_list": "", "function": "Required for cellular morphogenesis and polarization of the cortical cytoskeleton. It might act in concert with proteins such as CDC42 and CDC43 to limit the region of cortical patch formation to the cortex of the bud. Required for the accumulation and/or maintenance of plasma membrane H(+)-ATPase on the cell surface., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W0V0;Q02434", "ec_number_list": [], "go_molecular_function": "GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0051015 actin filament binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0035615 clathrin adaptor activity;GO:0032051 clathrin light chain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030136 clathrin-coated vesicle;GO:0030864 cortical actin cytoskeleton;GO:0030479 actin cortical patch;GO:0000131 incipient cellular bud site", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0048268 clathrin coat assembly;GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation;GO:0000147 actin cortical patch assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P33338-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33339-1", "uniprot_id": [ { "id": "TFC4_YEAST", "url": "https://www.uniprot.org/uniprot/P33339", "type": "external" } ], "mass": 120229.0, "length": 1025, "protein_name": "Transcription factor tau 131 kDa subunit", "gene_name": "TFC4", "organism": "Yeast", "refseq_name": "transcription factor TFIIIC subunit TFC4", "refseq_ac": [ { "id": "NP_011561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011561", "type": "external" } ], "gene_names_uniprotkb": "TFC4; PCF1", "gene_names_refseq": "PCF1; TFC4", "protein_names_uniprotkb": "Transcription factor tau 131 kDa subunit; TFIIIC 131 kDa subunit; Transcription factor C subunit 4", "protein_names_refseq": "transcription factor TFIIIC subunit TFC4", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR047C); (R-SCE-76061); (R-SCE-76066)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10559229;12167707;12930823;14562095;14562106;16273108;1922038;19779198;2180956;22814378;23749301;24374639;2686985;32597660;33491328;7488859;7688737;8264649;8387209;9169869;9372943", "class_list": "", "function": "TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. TFC4 is the TFIIIB-assembling subunit of TFIIIC and essential for viability., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 21, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUI4;Q45U37", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0000127 transcription factor TFIIIC complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0042791 5S class rRNA transcription by RNA polymerase III;GO:0006383 transcription by RNA polymerase III;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P33339-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33399-1", "uniprot_id": [ { "id": "LHP1_YEAST", "url": "https://www.uniprot.org/uniprot/P33399", "type": "external" } ], "mass": 32104.0, "length": 275, "protein_name": "La protein homolog", "gene_name": "LHP1", "organism": "Yeast", "refseq_name": "tRNA maturation protein LHP1", "refseq_ac": [ { "id": "NP_010232", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010232", "type": "external" } ], "gene_names_uniprotkb": "LHP1; LAH1; YLA1", "gene_names_refseq": "LAH1; LHP1; YLA1", "protein_names_uniprotkb": "La protein homolog; La autoantigen homolog; La ribonucleoprotein", "protein_names_refseq": "tRNA maturation protein LHP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL051W)", "pathway_count": 1, "publication_count": 44, "publication_id_list": "10330157;10385518;10564276;10747032;10891482;11333229;11720288;12077351;12828645;14627812;14657028;14704279;15579677;15665377;16581807;17287358;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;22814378;23749301;23865587;24374639;32597660;33481703;33491328;7799435;8035818;8408076;9150139;9169867;9412461;9817748;9851972;9857199", "class_list": "", "function": "Molecular chaperone that binds nascent RNA polymerase III transcripts, stabilizing these RNAs against exonucleases. Required for the 3' endonucleolytic cleavage that matures tRNA precursors and for efficient folding of certain pre-tRNAs. Cooperates with GCD14 in the maturation of a subset of RNA polymerase III transcripts. Functions also in the assembly of certain RNA polymerase II-transcribed RNAs into RNPs. Binds and stabilizes newly synthesized U6 snRNA as well as precursors of U3 snRNA from degradation. Facilitates efficient Sm protein binding, thus assisting formation of the U4/U6 snRNP. Required for Ty3 normal transposition frequency., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRU5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0000049 tRNA binding;GO:0017070 U6 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "P33399-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33400-1", "uniprot_id": [ { "id": "PACC_YEAST", "url": "https://www.uniprot.org/uniprot/P33400", "type": "external" } ], "mass": 68232.0, "length": 625, "protein_name": "pH-response transcription factor pacC/RIM101", "gene_name": "RIM101", "organism": "Yeast", "refseq_name": "alkaline-responsive transcriptional regulator RIM101", "refseq_ac": [ { "id": "NP_011836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011836", "type": "external" } ], "gene_names_uniprotkb": "RIM101; RIM1", "gene_names_refseq": "RIM101; RIM1", "protein_names_uniprotkb": "pH-response transcription factor pacC/RIM101; Regulator of IME2 protein 1; pH-response regulator protein RIM101", "protein_names_refseq": "alkaline-responsive transcriptional regulator RIM101", "tax_id": 559292, "disease": "", "pathway": " (sce:YHL027W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11050096;11698381;12509465;14562095;14562106;17322287;18407956;19779198;20382759;21177495;23749301;24374639;32597660;33229814;33481703;33491328;8091229;8367297;9017390", "class_list": "", "function": "Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself), mainly by repressing transcriptional repressors of those genes, and represses transcription of acid-expressed genes. Required for meiosis, sporulation and invasive growth., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D3DKU1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0071454 cellular response to anoxia;GO:0071469 cellular response to alkaline pH;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P33400-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33401-1", "uniprot_id": [ { "id": "PGM1_YEAST", "url": "https://www.uniprot.org/uniprot/P33401", "type": "external" } ], "mass": 63112.0, "length": 570, "protein_name": "Phosphoglucomutase 1", "gene_name": "PGM1", "organism": "Yeast", "refseq_name": "phosphoglucomutase PGM1", "refseq_ac": [ { "id": "NP_012795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012795", "type": "external" } ], "gene_names_uniprotkb": "PGM1", "gene_names_refseq": "PGM1", "protein_names_uniprotkb": "Phosphoglucomutase 1; 5.4.2.2; Glucose phosphomutase 1; PGM 1", "protein_names_refseq": "phosphoglucomutase PGM1", "tax_id": 559292, "disease": "congenital disorder of glycosylation It (Disease Ontology:DOID:0080570); endometrial cancer (Disease Ontology:DOID:1380); teratoma (Disease Ontology:DOID:3307)", "pathway": " (sce:YKL127W); (R-SCE-3322077); (R-SCE-6798695); (R-SCE-70221); (R-SCE-70370)", "pathway_count": 5, "publication_count": 25, "publication_id_list": "14264884;14562095;14562106;15665377;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21177495;22218487;22814378;23103740;23749301;24374639;32597660;33481703;33491328;5231755;5784209;8119301;8196765", "class_list": "", "function": "Minor phosphoglucomutase isozyme that catalyzes the reversible interconversion of alpha-D-glucose 1-phosphate and alpha-D-glucose 6-phosphate (PubMed:23103740, PubMed:5784209). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable). Constitutes about 10-20% of the phosphoglucomutase activity in the cell (PubMed:14264884, PubMed:5231755). Key enzyme in hexose metabolism. The forward reaction is an essential step in the energy metabolism of galactose since the product of the galactose pathway enzymes in yeast is glucose 1-phosphate. The reverse reaction is an essential step for biosynthesis when carbon sources other than galactose are the energy source because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose (PubMed:14264884)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX68", "ec_number_list": [ { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.4.23.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.25", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.7.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.59", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.3.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004614 phosphoglucomutase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006006 glucose metabolic process;GO:0005978 glycogen biosynthetic process;GO:0019255 glucose 1-phosphate metabolic process;GO:0019388 galactose catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P33401-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33413-1", "uniprot_id": [ { "id": "DUR3_YEAST", "url": "https://www.uniprot.org/uniprot/P33413", "type": "external" } ], "mass": 80617.0, "length": 735, "protein_name": "Urea active transporter", "gene_name": "DUR3", "organism": "Yeast", "refseq_name": "Dur3p", "refseq_ac": [ { "id": "NP_011847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011847", "type": "external" } ], "gene_names_uniprotkb": "DUR3", "gene_names_refseq": "DUR3", "protein_names_uniprotkb": "Urea active transporter", "protein_names_refseq": "Dur3p", "tax_id": 559292, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); thyroid dyshormonogenesis 1 (Disease Ontology:DOID:0112185)", "pathway": " (sce:YHL016C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16847258;17218313;17322287;19684113;24374639;34965436;8091229;8335627", "class_list": "", "function": "Required for active transport of urea., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKP5", "ec_number_list": [], "go_molecular_function": "GO:0015489 putrescine transmembrane transporter activity;GO:0015204 urea transmembrane transporter activity;GO:0015606 spermidine transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0015840 urea transport;GO:0015847 putrescine transport;GO:0015848 spermidine transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P33413-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33418-1", "uniprot_id": [ { "id": "XPOT_YEAST", "url": "https://www.uniprot.org/uniprot/P33418", "type": "external" } ], "mass": 126820.0, "length": 1100, "protein_name": "Exportin-T", "gene_name": "LOS1", "organism": "Yeast", "refseq_name": "Ran GTPase-binding protein LOS1", "refseq_ac": [ { "id": "NP_012717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012717", "type": "external" } ], "gene_names_uniprotkb": "LOS1", "gene_names_refseq": "LOS1", "protein_names_uniprotkb": "Exportin-T; Exportin(tRNA); Karyopherin-beta; tRNA exportin", "protein_names_refseq": "Ran GTPase-binding protein LOS1", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL205W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10713174;10727409;10766739;14562106;14640976;15905365;16040803;17203074;17544521;17634288;18045534;23749301;24374639;3031485;7363329;8196765;8366091;8641292;8725220;9774653;9802895;9971735", "class_list": "", "function": "tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Preferentially interacts with tRNAs with mature 5'- and 3'-termini and does not distinguish between intron-containing and spliced tRNAs. In the nucleus binds to tRNA and to the Ran-GTPases GSP1 or GSP2 in their active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the tRNA from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWZ8", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0016363 nuclear matrix", "go_biological_process": "GO:0071528 tRNA re-export from nucleus;GO:0006409 tRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P33418-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33419-1", "uniprot_id": [ { "id": "SPC29_YEAST", "url": "https://www.uniprot.org/uniprot/P33419", "type": "external" } ], "mass": 29280.0, "length": 253, "protein_name": "Spindle pole component 29", "gene_name": "SPC29", "organism": "Yeast", "refseq_name": "Spc29p", "refseq_ac": [ { "id": "NP_015201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015201", "type": "external" } ], "gene_names_uniprotkb": "SPC29; LPH3W; LPH3; NIP29", "gene_names_refseq": "LPH3; NIP29; SPC29", "protein_names_uniprotkb": "Spindle pole component 29", "protein_names_refseq": "Spc29p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL124W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10339566;10654940;17287358;18407956;19269975;19779198;19795423;19823750;20368617;20489023;20702584;21177495;22218487;23749301;24374639;30044722;30516470;32597660;33481703;33491328;9169875", "class_list": "", "function": "Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Links the central plaque component SPC42 to the inner plaque component SPC110., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 31, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3P3", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005816 spindle pole body;GO:0005823 central plaque of spindle pole body;GO:0061493 central plaque of mitotic spindle pole body", "go_biological_process": "GO:0010968 regulation of microtubule nucleation;GO:1903087 mitotic spindle pole body duplication", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P33419-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33420-1", "uniprot_id": [ { "id": "NIP80_YEAST", "url": "https://www.uniprot.org/uniprot/P33420", "type": "external" } ], "mass": 100290.0, "length": 868, "protein_name": "Protein NIP100", "gene_name": "NIP100", "organism": "Yeast", "refseq_name": "Nip100p", "refseq_ac": [ { "id": "NP_015151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015151", "type": "external" } ], "gene_names_uniprotkb": "NIP100; NIP80", "gene_names_refseq": "NIP100; PAC13", "protein_names_uniprotkb": "Protein NIP100; Protein NIP80", "protein_names_refseq": "Nip100p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL174C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;24374639;33229814;33491328;9169875;9658168", "class_list": "", "function": "Motor-binding component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding (By similarity). The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W3J4;Q08917", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0051286 cell tip;GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005874 microtubule", "go_biological_process": "GO:0030048 actin filament-based movement;GO:0000132 establishment of mitotic spindle orientation;GO:0000743 nuclear migration involved in conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P33420-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33421-1", "uniprot_id": [ { "id": "SDH3_YEAST", "url": "https://www.uniprot.org/uniprot/P33421", "type": "external" } ], "mass": 22068.0, "length": 198, "protein_name": "Succinate dehydrogenase [ubiquinone] cytochrome b subunit, mitochondrial", "gene_name": "SDH3", "organism": "Yeast", "refseq_name": "succinate dehydrogenase cytochrome b subunit SDH3", "refseq_ac": [ { "id": "NP_012781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012781", "type": "external" } ], "gene_names_uniprotkb": "SDH3; CYB3; YKL4", "gene_names_refseq": "CYB3; SDH3; YKL4", "protein_names_uniprotkb": "Succinate dehydrogenase [ubiquinone] cytochrome b subunit, mitochondrial", "protein_names_refseq": "succinate dehydrogenase cytochrome b subunit SDH3", "tax_id": 559292, "disease": "paraganglioma (Disease Ontology:DOID:0050773); pheochromocytoma/paraganglioma syndrome 3 (Disease Ontology:DOID:0061218); Carney-Stratakis syndrome (Disease Ontology:DOID:0080533); Leigh disease (Disease Ontology:DOID:3652); lung non-small cell carcinoma (Disease Ontology:DOID:3908); gastrointestinal stromal tumor (Disease Ontology:DOID:9253)", "pathway": " (sce:YKL141W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10446163;11803020;14562106;14672929;14672930;1574929;17322287;24374639;8152421;8195189;8196765", "class_list": "", "function": "Membrane-anchoring mono-heme cytochrome b subunit of succinate dehydrogenase (SDH) that is involved in system II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH3 and SDH4 form the membrane dimer that anchors the catalytic dimer formed by SDH1 and SDH2 to the matrix surface of the mitochondrial inner membrane. Electrons originating from the catalytic dimer enter the membrane dimer for ubiquinone reduction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX55", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0048038 quinone binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex;GO:0045273 respiratory chain complex II (succinate dehydrogenase)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0045039 protein insertion into mitochondrial inner membrane;GO:0006121 mitochondrial electron transport, succinate to ubiquinone;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P33421-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33441-1", "uniprot_id": [ { "id": "MFT1_YEAST", "url": "https://www.uniprot.org/uniprot/P33441", "type": "external" } ], "mass": 44996.0, "length": 392, "protein_name": "THO complex subunit MFT1", "gene_name": "MFT1", "organism": "Yeast", "refseq_name": "Mft1p", "refseq_ac": [ { "id": "NP_013649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013649", "type": "external" } ], "gene_names_uniprotkb": "MFT1", "gene_names_refseq": "MFT1; MFT52", "protein_names_uniprotkb": "THO complex subunit MFT1; Mitochondrial fusion target protein 1", "protein_names_refseq": "Mft1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YML062C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "11060033;11979277;12093753;12871933;14527416;14562095;14562106;15192704;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21177495;22814378;24374639;30516470;32597660;33481703;33491328;8458428;9169872", "class_list": "", "function": "Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZB1", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0000445 THO complex part of transcription export complex;GO:0000781 chromosome, telomeric region;GO:0000446 nucleoplasmic THO complex", "go_biological_process": "GO:0006310 DNA recombination;GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P33441-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33442-1", "uniprot_id": [ { "id": "RS3A1_YEAST", "url": "https://www.uniprot.org/uniprot/P33442", "type": "external" } ], "mass": 28743.0, "length": 255, "protein_name": "Small ribosomal subunit protein eS1A", "gene_name": "RPS1A", "organism": "Yeast", "refseq_name": "40S ribosomal protein eS1 RPS1A", "refseq_ac": [ { "id": "NP_013546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013546", "type": "external" } ], "gene_names_uniprotkb": "RPS1A; L9753.9; PLC1; RPS10A", "gene_names_refseq": "RP10A; RPS1A", "protein_names_uniprotkb": "Small ribosomal subunit protein eS1A; 40S ribosomal protein S1-A; RP10A", "protein_names_refseq": "40S ribosomal protein eS1 RPS1A", "tax_id": 559292, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (sce:YLR441C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10601260;1451783;14562095;14562106;15665377;17287358;17322287;17330950;18407956;19779198;22096102;23749301;24374639;24524803;30516470;33481703;33491328;6098447;8143753;9169871;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ76", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0030686 90S preribosome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0002181 cytoplasmic translation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P33442-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33734-1", "uniprot_id": [ { "id": "HIS5_YEAST", "url": "https://www.uniprot.org/uniprot/P33734", "type": "external" } ], "mass": 61068.0, "length": 552, "protein_name": "Imidazole glycerol phosphate synthase hisHF", "gene_name": "HIS7", "organism": "Yeast", "refseq_name": "imidazoleglycerol-phosphate synthase", "refseq_ac": [ { "id": "NP_009807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009807", "type": "external" } ], "gene_names_uniprotkb": "HIS7; YBR1640", "gene_names_refseq": "HIS7", "protein_names_uniprotkb": "Imidazole glycerol phosphate synthase hisHF; 4.3.2.10; IGP synthase; IGPS; ImGP synthase", "protein_names_refseq": "imidazoleglycerol-phosphate synthase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR248C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11591353;12795595;12795596;14562106;18407956;24374639;33481703;33491328;7813418;8366040", "class_list": "", "function": "IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQP4", "ec_number_list": [ { "id": "6.3.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.5", "type": "external" }, { "id": "6.3.4.16", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.16", "type": "external" }, { "id": "2.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.2", "type": "external" }, { "id": "3.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.2", "type": "external" }, { "id": "4.3.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.10", "type": "external" }, { "id": "4.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.3.6", "type": "external" } ], "go_molecular_function": "GO:0016829 lyase activity;GO:0004359 glutaminase activity;GO:0000107 imidazoleglycerol-phosphate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000105 L-histidine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P33734-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33748-1", "uniprot_id": [ { "id": "MSN2_YEAST", "url": "https://www.uniprot.org/uniprot/P33748", "type": "external" } ], "mass": 77861.0, "length": 704, "protein_name": "Zinc finger protein MSN2", "gene_name": "MSN2", "organism": "Yeast", "refseq_name": "stress-responsive transcriptional activator MSN2", "refseq_ac": [ { "id": "NP_013751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013751", "type": "external" } ], "gene_names_uniprotkb": "MSN2; YM9532.02C", "gene_names_refseq": "MSN2", "protein_names_uniprotkb": "Zinc finger protein MSN2; Multicopy suppressor of SNF1 protein 2", "protein_names_refseq": "stress-responsive transcriptional activator MSN2", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR037C)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "11875433;12090248;12732613;14562106;16281053;17287358;17330950;17563356;18375619;18407956;19684113;19779198;19795423;19823750;20702584;21177495;22218487;23275436;23749301;24374639;24981510;27618436;28330760;30516470;32597660;33481703;33491328;8321194;8641288;9169872", "class_list": "", "function": "Positive transcriptional factor that acts as a component of the stress responsive system. Recognizes and binds to the stress response element (STRE) which is involved in the response to various forms of stress (heat, oxidative, osmotic, etc.). Involved in the regulation of the CTT1, DDR2, HSP12 genes. May be regulated via WHI2-PSR1 complex phosphatase activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZL2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071476 cellular hypotonic response;GO:0070417 cellular response to cold;GO:0061433 cellular response to caloric restriction;GO:0071469 cellular response to alkaline pH;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P33748-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33751-1", "uniprot_id": [ { "id": "PAD1_YEAST", "url": "https://www.uniprot.org/uniprot/P33751", "type": "external" } ], "mass": 26733.0, "length": 242, "protein_name": "Flavin prenyltransferase PAD1, mitochondrial", "gene_name": "PAD1", "organism": "Yeast", "refseq_name": "phenylacrylic acid decarboxylase PAD1", "refseq_ac": [ { "id": "NP_010827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010827", "type": "external" } ], "gene_names_uniprotkb": "PAD1; POF1", "gene_names_refseq": "PAD1; POF1", "protein_names_uniprotkb": "Flavin prenyltransferase PAD1, mitochondrial; 2.5.1.129; PAD; Phenylacrylic acid decarboxylase 1", "protein_names_refseq": "phenylacrylic acid decarboxylase PAD1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR538W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11693915;12903944;14562095;14562106;16232824;17054397;17766451;17889824;20471595;20844764;21547456;23111598;24374639;25647642;25852989;8181743;9169867", "class_list": "", "function": "Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1/ubiD (PubMed:25647642). The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN (By similarity). Involved in the decarboxylation of phenylacrylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives which play the role of aroma metabolites. Also involved in the degradation of the food preservative sorbic acid (2,4-hexadienoic acid) to a volatile hydrocarbon, 1,3-pentadiene. Not essential for ubiquinone synthesis (PubMed:17889824, PubMed:20471595). Can rescue Q biosynthesis in E.coli strains lacking UbiX (PubMed:17889824). Has mRNA binding activity (PubMed:20844764)., [UniProtKB, HAMAP, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTF7", "ec_number_list": [ { "id": "2.5.1.129", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.129", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0016831 carboxy-lyase activity;GO:0106141 flavin prenyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0046281 cinnamic acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P33751-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33753-1", "uniprot_id": [ { "id": "TRM2_YEAST", "url": "https://www.uniprot.org/uniprot/P33753", "type": "external" } ], "mass": 72852.0, "length": 639, "protein_name": "tRNA (uracil(54)-C(5))-methyltransferase", "gene_name": "TRM2", "organism": "Yeast", "refseq_name": "tRNA (uracil(54)-C(5))-methyltransferase", "refseq_ac": [ { "id": "NP_012982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012982", "type": "external" } ], "gene_names_uniprotkb": "TRM2; NUC2; NUD1; RNC1", "gene_names_refseq": "NUC2; NUD1; RNC1; TRM2", "protein_names_uniprotkb": "tRNA (uracil(54)-C(5))-methyltransferase; 2.1.1.35; Rho-associated nuclease 1; Transfer RNA methyltransferase 2; tRNA(m5U54)-methyltransferase", "protein_names_refseq": "tRNA (uracil(54)-C(5))-methyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR056W)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10864043;12003492;12844361;1408836;17205207;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;27821475;32597660;33481703;33491328;37181630;7074684;8196765;8256523", "class_list": "", "function": "Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA (PubMed:10864043, PubMed:12003492, PubMed:17205207, PubMed:7074684). May also have a role in tRNA stabilization or maturation (PubMed:12003492). Also involved in the formation of 5-methyl-uridine in mRNA, which alters the elongation step in protein synthesis in a position-dependent manner, slowing amino acid addition by the ribosome (PubMed:37181630). Displays 5'-3' exonuclease activity on double-strand (ds) DNA, and endonuclease activity on single-strand (ss) DNA, characteristic of endo-exonucleases. May be involved in DNA double-strand break repair (PubMed:17205207)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXB7;P30618;Q86ZR6;Q9HGQ5", "ec_number_list": [ { "id": "2.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.35", "type": "external" } ], "go_molecular_function": "GO:0000014 single-stranded DNA endodeoxyribonuclease activity;GO:0051908 double-stranded DNA 5'-3' DNA exonuclease activity;GO:0030697 tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent", "go_cellular_component": "", "go_biological_process": "GO:0006400 tRNA modification;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P33753-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33767-1", "uniprot_id": [ { "id": "OSTB_YEAST", "url": "https://www.uniprot.org/uniprot/P33767", "type": "external" } ], "mass": 49392.0, "length": 430, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1", "gene_name": "WBP1", "organism": "Yeast", "refseq_name": "dolichyl-diphosphooligosaccharide-protein glycotransferase", "refseq_ac": [ { "id": "NP_010914", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010914", "type": "external" } ], "gene_names_uniprotkb": "WBP1", "gene_names_refseq": "WBP1", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1; Oligosaccharyl transferase subunit WBP1; Oligosaccharyl transferase subunit beta", "protein_names_refseq": "dolichyl-diphosphooligosaccharide-protein glycotransferase", "tax_id": 559292, "disease": "congenital disorder of glycosylation Ir (Disease Ontology:DOID:0080569)", "pathway": " (sce:YEL002C); (R-SCE-6798695)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "11580295;14562095;14562106;15831493;15886282;1600939;16096345;16096346;16297388;1724755;23481256;24374639;29301962;29466327;7703229;8175708;8181570;9169868;9405463;9878773", "class_list": "", "function": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D3DLP5", "ec_number_list": [], "go_molecular_function": "GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex", "go_biological_process": "GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P33767-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33775-1", "uniprot_id": [ { "id": "PMT1_YEAST", "url": "https://www.uniprot.org/uniprot/P33775", "type": "external" } ], "mass": 92675.0, "length": 817, "protein_name": "Dolichyl-phosphate-mannose--protein mannosyltransferase 1", "gene_name": "PMT1", "organism": "Yeast", "refseq_name": "dolichyl-phosphate-mannose-protein mannosyltransferase PMT1", "refseq_ac": [ { "id": "NP_010188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010188", "type": "external" } ], "gene_names_uniprotkb": "PMT1; D2390", "gene_names_refseq": "PMT1", "protein_names_uniprotkb": "Dolichyl-phosphate-mannose--protein mannosyltransferase 1; 2.4.1.109", "protein_names_refseq": "dolichyl-phosphate-mannose-protein mannosyltransferase PMT1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL095W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10085156;10764776;12551906;14562106;16847258;18182384;21147851;21956107;22814378;24374639;8367478;8543034;8918452;8923743;9169867;9466258", "class_list": "glycogene;glycosyltransferase", "function": "Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT2 and more rarely with PMT3 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins. The PMT1-PMT2 complex participates in oxidative protein folding, ER-associated protein degradation (ERAD), as well as ER export. Required for incorporation of proteins in the cell wall., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VRQ4", "ec_number_list": [ { "id": "2.4.1.109", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.109", "type": "external" } ], "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0097583 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex;GO:0097582 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex", "go_biological_process": "GO:0036503 ERAD pathway;GO:0035269 protein O-linked glycosylation via mannose;GO:0032527 protein exit from endoplasmic reticulum;GO:1900101 regulation of endoplasmic reticulum unfolded protein response;GO:0009272 fungal-type cell wall biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P33775-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33891-1", "uniprot_id": [ { "id": "TIP20_YEAST", "url": "https://www.uniprot.org/uniprot/P33891", "type": "external" } ], "mass": 81167.0, "length": 701, "protein_name": "Protein transport protein TIP20", "gene_name": "TIP20", "organism": "Yeast", "refseq_name": "Tip20p", "refseq_ac": [ { "id": "NP_116577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116577", "type": "external" } ], "gene_names_uniprotkb": "TIP20; TIP1", "gene_names_refseq": "TIP1; TIP20", "protein_names_uniprotkb": "Protein transport protein TIP20", "protein_names_refseq": "Tip20p", "tax_id": 559292, "disease": "infantile liver failure syndrome (Disease Ontology:DOID:0080716)", "pathway": " (sce:YGL145W); (R-SCE-6811434)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "14562106;15942868;15958492;16429126;18407956;19795423;19823750;22814378;24374639;33491328;8334998;9046099;9169869", "class_list": "", "function": "Required for protein transport between the Golgi and the endoplasmic reticulum. May contribute to tethering of coatomer-coated retrograde transport vesicles to the ER membrane through interaction with and stabilization of the SNARE complex., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU04", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0070939 Dsl1/NZR complex;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006914 autophagy;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P33891-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33895-1", "uniprot_id": [ { "id": "NUF2_YEAST", "url": "https://www.uniprot.org/uniprot/P33895", "type": "external" } ], "mass": 52973.0, "length": 451, "protein_name": "Kinetochore protein NUF2", "gene_name": "NUF2", "organism": "Yeast", "refseq_name": "kinetochore-associated Ndc80 complex subunit NUF2", "refseq_ac": [ { "id": "NP_014572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014572", "type": "external" } ], "gene_names_uniprotkb": "NUF2", "gene_names_refseq": "NUF2", "protein_names_uniprotkb": "Kinetochore protein NUF2", "protein_names_refseq": "kinetochore-associated Ndc80 complex subunit NUF2", "tax_id": 559292, "disease": "oral cavity carcinoma in situ (Disease Ontology:DOID:0050610); castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); stomach cancer (Disease Ontology:DOID:10534); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YOL069W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11179222;11266451;12514103;14562106;15371542;15809444;17322287;24374639;33491328;8188751;9169874;9178509", "class_list": "", "function": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1Z8;Q6B1X5", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0031262 Ndc80 complex;GO:0005634 nucleus;GO:0000776 kinetochore;GO:0005876 spindle microtubule;GO:0000779 condensed chromosome, centromeric region", "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051383 kinetochore organization;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0045132 meiotic chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P33895-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34072-1", "uniprot_id": [ { "id": "MKS1_YEAST", "url": "https://www.uniprot.org/uniprot/P34072", "type": "external" } ], "mass": 65643.0, "length": 584, "protein_name": "Negative regulator of RAS-cAMP pathway", "gene_name": "MKS1", "organism": "Yeast", "refseq_name": "Mks1p", "refseq_ac": [ { "id": "NP_014323", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014323", "type": "external" } ], "gene_names_uniprotkb": "MKS1; LYS80; N2344; N2347", "gene_names_refseq": "LYS80; MKS1", "protein_names_uniprotkb": "Negative regulator of RAS-cAMP pathway", "protein_names_refseq": "Mks1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL076W)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "15665377;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33229814;33481703;33491328;8386801;8701611;9169873", "class_list": "", "function": "Negative regulator of Ras-cAMP pathway. Involved in transcriptional regulation of galactose-inducible genes., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 42, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "D6W1A3;Q02533", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006808 regulation of nitrogen utilization;GO:0031930 mitochondria-nucleus signaling pathway;GO:2000220 regulation of pseudohyphal growth", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P34072-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34077-1", "uniprot_id": [ { "id": "NIC96_YEAST", "url": "https://www.uniprot.org/uniprot/P34077", "type": "external" } ], "mass": 96174.0, "length": 839, "protein_name": "Nucleoporin NIC96", "gene_name": "NIC96", "organism": "Yeast", "refseq_name": "linker nucleoporin NIC96", "refseq_ac": [ { "id": "NP_116657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116657", "type": "external" } ], "gene_names_uniprotkb": "NIC96", "gene_names_refseq": "NIC96", "protein_names_uniprotkb": "Nucleoporin NIC96; 96 kDa nucleoporin-interacting component; Nuclear pore protein NIC96", "protein_names_refseq": "linker nucleoporin NIC96", "tax_id": 559292, "disease": "nephrotic syndrome type 12 (Disease Ontology:DOID:0080387)", "pathway": " (sce:YFR002W)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10428845;10617624;10684247;10806080;11121302;11689687;12403813;12496130;12730220;12791264;14562106;18407956;19779198;19795423;19823750;23749301;24374639;32597660;33481703;33491328;7670463;7688296;7828598;8522578;8682854;8682855;8789262;9017593", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NIC96, which is localized to the core of the NPC and the distal ring of the nuclear basket, is required for de novo assembly of NPCs. It is involved in nuclear GSP1 import., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VTN2", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0044612 nuclear pore linkers", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0000055 ribosomal large subunit export from nucleus;GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P34077-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34110-1", "uniprot_id": [ { "id": "VPS35_YEAST", "url": "https://www.uniprot.org/uniprot/P34110", "type": "external" } ], "mass": 109142.0, "length": 944, "protein_name": "Vacuolar protein sorting-associated protein 35", "gene_name": "VPS35", "organism": "Yeast", "refseq_name": "retromer subunit VPS35", "refseq_ac": [ { "id": "NP_012381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012381", "type": "external" } ], "gene_names_uniprotkb": "VPS35; J0580; VPT7", "gene_names_refseq": "ENV1; GRD9; VPS35; VPT7", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 35; Vacuolar protein-targeting protein 7", "protein_names_refseq": "retromer subunit VPS35", "tax_id": 559292, "disease": "Parkinson's disease 17 (Disease Ontology:DOID:0060897); brain cancer (Disease Ontology:DOID:1319); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (sce:YJL154C); (R-SCE-3238698)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "14562106;1498362;18407956;19779198;21126336;21177495;22814378;24374639;33481703;33491328;34965436;8641269;8813765;9700157", "class_list": "", "function": "Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor VPS10. Vacuolar carboxypeptidase Y (CPY) sorting is completely dependent on the presence of functional VPS35. The latter may play a role in the function, modification or packaging of a CPY-specific receptor complex. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS29-VPS26-VPS35 subcomplex may be involved in cargo selection., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW33", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030906 retromer, cargo-selective complex;GO:0005768 endosome;GO:0005829 cytosol;GO:0012505 endomembrane system;GO:0005770 late endosome", "go_biological_process": "GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response;GO:0045053 protein retention in Golgi apparatus;GO:0006886 intracellular protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P34110-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34111-1", "uniprot_id": [ { "id": "TFC3_YEAST", "url": "https://www.uniprot.org/uniprot/P34111", "type": "external" } ], "mass": 132108.0, "length": 1160, "protein_name": "Transcription factor tau 138 kDa subunit", "gene_name": "TFC3", "organism": "Yeast", "refseq_name": "transcription factor TFIIIC subunit TFC3", "refseq_ac": [ { "id": "NP_009400", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009400", "type": "external" } ], "gene_names_uniprotkb": "TFC3; FUN24; TSV115", "gene_names_refseq": "FUN24; TFC3; TSV115", "protein_names_uniprotkb": "Transcription factor tau 138 kDa subunit; TFIIIC 138 kDa subunit; Transcription factor C subunit 3", "protein_names_refseq": "transcription factor TFIIIC subunit TFC3", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL001C); (R-SCE-76061); (R-SCE-76066)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "12533520;1279682;14562095;14562106;14576278;18407956;19795423;19823750;21177495;2180956;23749301;24374639;2651441;30516470;33481703;33491328;7688737;7731988;7941740;8083243;9418847", "class_list": "", "function": "TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. TFC3 is essential for cell viability. Cooperates with TFC6 in DNA binding., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPL5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0000127 transcription factor TFIIIC complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0042791 5S class rRNA transcription by RNA polymerase III;GO:0006383 transcription by RNA polymerase III;GO:0006384 transcription initiation at RNA polymerase III promoter;GO:0071168 protein localization to chromatin", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P34111-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34160-1", "uniprot_id": [ { "id": "NCBP1_YEAST", "url": "https://www.uniprot.org/uniprot/P34160", "type": "external" } ], "mass": 100018.0, "length": 861, "protein_name": "Nuclear cap-binding protein complex subunit 1", "gene_name": "STO1", "organism": "Yeast", "refseq_name": "Sto1p", "refseq_ac": [ { "id": "NP_013844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013844", "type": "external" } ], "gene_names_uniprotkb": "STO1; CBC1; CBP80; GCR3; SUT1; YM8564.07; YM9553.01", "gene_names_refseq": "CBC1; CBP80; GCR3; STO1; SUT1", "protein_names_uniprotkb": "Nuclear cap-binding protein complex subunit 1; 80 kDa nuclear cap-binding protein; CBP80; Glycolysis regulation protein 3; NCBP 80 kDa subunit; Protein SUT1; Suppressor of TOP1 protein", "protein_names_refseq": "Sto1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR125W); (R-SCE-113418); (R-SCE-674695); (R-SCE-72086); (R-SCE-72203); (R-SCE-77595); (R-SCE-975956); (R-SCE-975957)", "pathway_count": 8, "publication_count": 23, "publication_id_list": "10072386;10490594;10504710;10733586;10823828;10949040;10958635;12756324;12897126;14562106;14671320;1512188;15753296;16166263;16427013;16729021;24374639;33491328;8811086;8846890;8858145;9169872;9499403", "class_list": "", "function": "Component of the CBC complex, which binds co-transcriptionally to the 5'-cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. The CBC complex is required for efficient pre-mRNA splicing through efficient commitment complex and spliceosome formation. Together with NPL3, the CBC complex is required for export of mRNAs out of the nucleus. The CBC complex is also involved in nuclear mRNA degradation, probably by directing the mRNAs to the sites of degradation. Affects replication of the positive-strand RNA virus BMV., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZU8", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0000339 RNA cap binding", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm;GO:0000243 commitment complex;GO:0005846 nuclear cap binding complex", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0006970 response to osmotic stress;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P34160-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34161-1", "uniprot_id": [ { "id": "YOX1_YEAST", "url": "https://www.uniprot.org/uniprot/P34161", "type": "external" } ], "mass": 42739.0, "length": 385, "protein_name": "Homeobox protein YOX1", "gene_name": "YOX1", "organism": "Yeast", "refseq_name": "Yox1p", "refseq_ac": [ { "id": "NP_013685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013685", "type": "external" } ], "gene_names_uniprotkb": "YOX1", "gene_names_refseq": "YOX1", "protein_names_uniprotkb": "Homeobox protein YOX1", "protein_names_refseq": "Yox1p", "tax_id": 559292, "disease": "clubfoot (Disease Ontology:DOID:11836)", "pathway": " (sce:YML027W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12464633;14562106;17322287;18407956;19779198;19795423;19823750;20702584;22218487;23749301;24374639;24909858;32597660;33481703;33491328;8096171;9169872", "class_list": "", "function": "Transcriptional repressor required to restrict transcription of ECB-dependent genes to the G1/M phase by repressing their transcription during the interval from late G1 to M phases. Genes that contain a ECB (early cell box) element in their transcription regulatory region are transcribed only during G1/M phases. In vitro, is capable of binding to the DNA of the leucine tRNA gene., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZE7", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P34161-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34162-1", "uniprot_id": [ { "id": "MED20_YEAST", "url": "https://www.uniprot.org/uniprot/P34162", "type": "external" } ], "mass": 22894.0, "length": 210, "protein_name": "Mediator of RNA polymerase II transcription subunit 20", "gene_name": "SRB2", "organism": "Yeast", "refseq_name": "Srb2p", "refseq_ac": [ { "id": "NP_011907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011907", "type": "external" } ], "gene_names_uniprotkb": "SRB2; HRS2; MED20", "gene_names_refseq": "HRS2; MED20; SRB2", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 20; Hyper-recombination suppressor protein 2; Mediator complex subunit 20; Suppressor of RNA polymerase B 2", "protein_names_refseq": "Srb2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR041C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "12191485;14562095;14562106;15175151;15477388;1591782;16002404;16076843;16109375;16263706;16885025;16964259;17192271;22814378;24374639;8091229;8187178;8324825;9660972", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKY9", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019904 protein domain specific binding;GO:0001094 TFIID-class transcription factor complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0031669 cellular response to nutrient levels;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P34162-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34163-1", "uniprot_id": [ { "id": "TGL1_YEAST", "url": "https://www.uniprot.org/uniprot/P34163", "type": "external" } ], "mass": 62979.0, "length": 548, "protein_name": "Sterol esterase TGL1", "gene_name": "TGL1", "organism": "Yeast", "refseq_name": "sterol esterase", "refseq_ac": [ { "id": "NP_012782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012782", "type": "external" } ], "gene_names_uniprotkb": "TGL1; YKL5", "gene_names_refseq": "TGL1; YKL5", "protein_names_uniprotkb": "Sterol esterase TGL1; 3.1.1.13; Triglyceride lipase-cholesterol esterase 1", "protein_names_refseq": "sterol esterase", "tax_id": 559292, "disease": "autosomal recessive congenital ichthyosis 8 (Disease Ontology:DOID:0060717); lysosomal acid lipase deficiency (Disease Ontology:DOID:0080217); Wolman disease (Disease Ontology:DOID:14497); cholesterol ester storage disease (Disease Ontology:DOID:14502)", "pathway": " (sce:YKL140W)", "pathway_count": 1, "publication_count": 31, "publication_id_list": "10515935;14562095;14562106;14640980;15665377;15713625;1574929;15922657;17287358;17330950;17563356;18407956;19111628;19779198;19795423;19823750;20702584;21126336;21177495;21820081;22106047;22218487;23613772;23749301;24374639;24868093;28866104;32597660;33481703;33491328;8196765", "class_list": "", "function": "Mediates the hydrolysis of steryl esters (SE) (PubMed:10515935, PubMed:14640980, PubMed:15713625). Preferentially hydrolyzes ergosteryl and zymosteryl esters (PubMed:19111628). Required for mobilization of SEs from lipid particles/droplets, thereby playing a central role in lipid metabolism and sterol homeostasis. Sterol intermediates stored in SE and set free by SE hydrolases are recycled to the sterol biosynthetic pathway and converted to the final product, ergosterol, in the endoplasmic reticulum. Also has weak lipase activity toward triglycerides at neutral pH, however, the physiological relevance of this activity is unclear (PubMed:15922657, PubMed:19111628, PubMed:28866104)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX56", "ec_number_list": [ { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" } ], "go_molecular_function": "GO:0004771 sterol ester esterase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0016020 membrane;GO:0005773 vacuole", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0016042 lipid catabolic process;GO:0016125 sterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P34163-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34167-1", "uniprot_id": [ { "id": "IF4B_YEAST", "url": "https://www.uniprot.org/uniprot/P34167", "type": "external" } ], "mass": 48522.0, "length": 436, "protein_name": "Eukaryotic translation initiation factor 4B", "gene_name": "TIF3", "organism": "Yeast", "refseq_name": "Tif3p", "refseq_ac": [ { "id": "NP_015489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015489", "type": "external" } ], "gene_names_uniprotkb": "TIF3; P9325.6; STM1; TIF42", "gene_names_refseq": "RBL3; STM1; TIF3", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4B; eIF-4B", "protein_names_refseq": "Tif3p", "tax_id": 559292, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); major depressive disorder (Disease Ontology:DOID:1470); Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (sce:YPR163C); (R-SCE-156827); (R-SCE-166208); (R-SCE-429947); (R-SCE-72649); (R-SCE-72662); (R-SCE-72702)", "pathway_count": 7, "publication_count": 21, "publication_id_list": "14562106;15665377;17322287;18407956;19684113;19779198;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32027465;32597660;33481703;33491328;34965436;8404865;8404866;9169875", "class_list": "", "function": "Involved in translation initiation. May be the homolog of mammalian eIF4B and be part of an RNA helicase. STM1/TIF3 is a non-essential gene., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4G4", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0043024 ribosomal small subunit binding;GO:0003727 single-stranded RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006413 translational initiation;GO:0097010 eukaryotic translation initiation factor 4F complex assembly;GO:0001731 formation of translation preinitiation complex;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P34167-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34218-1", "uniprot_id": [ { "id": "SAS3_YEAST", "url": "https://www.uniprot.org/uniprot/P34218", "type": "external" } ], "mass": 97582.0, "length": 831, "protein_name": "Histone acetyltransferase SAS3", "gene_name": "SAS3", "organism": "Yeast", "refseq_name": "histone acetyltransferase", "refseq_ac": [ { "id": "NP_009501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009501", "type": "external" } ], "gene_names_uniprotkb": "SAS3; YBL0507; YBL0515", "gene_names_refseq": "KAT6; SAS3", "protein_names_uniprotkb": "Histone acetyltransferase SAS3; 2.3.1.48; Something about silencing protein 3", "protein_names_refseq": "histone acetyltransferase", "tax_id": 559292, "disease": "Ohdo syndrome, SBBYS variant (Disease Ontology:DOID:0060290); DiGeorge syndrome (Disease Ontology:DOID:11198); leiomyoma (Disease Ontology:DOID:127); breast cancer (Disease Ontology:DOID:1612); bipolar disorder (Disease Ontology:DOID:3312); Noonan syndrome (Disease Ontology:DOID:3490); androgen insensitivity syndrome (Disease Ontology:DOID:4674)", "pathway": " (sce:YBL052C); (R-SCE-6804758)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10600516;10817755;11731478;14562095;16581777;17157260;23749301;24374639;25104842;33491328;7813418;8154187;8782818", "class_list": "", "function": "Catalytic component of the NuA3 histone acetyltransferase complex, that acetylates H3K14 (PubMed:10600516, PubMed:10817755, PubMed:11731478, PubMed:16581777, PubMed:17157260, PubMed:25104842). The NuA3 HAT complex has 2 functionally distinct forms. NuA3a binds H3K4me3, through the PHD finger of YNG1, and acetylates H3K14 at the promoter region of actively transcribed genes to promote transcription initiation. NuA3b binds H3K36me3 at the coding regions of actively transcribed genes, through the PWWP domain of PDP3, and coordinates transcription elongation (PubMed:17157260, PubMed:25104842). In vitro, SAS3 acetylates free histones H3 and H4 (PubMed:10600516). It is involved in silencing the HMR locus (PubMed:16581777, PubMed:8782818)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPU7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity;GO:0004402 histone acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0000781 chromosome, telomeric region;GO:1990467 NuA3a histone acetyltransferase complex;GO:1990468 NuA3b histone acetyltransferase complex", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030466 silent mating-type cassette heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P34218-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34219-1", "uniprot_id": [ { "id": "TOD6_YEAST", "url": "https://www.uniprot.org/uniprot/P34219", "type": "external" } ], "mass": 59226.0, "length": 525, "protein_name": "Transcriptional regulatory protein TOD6", "gene_name": "TOD6", "organism": "Yeast", "refseq_name": "Tod6p", "refseq_ac": [ { "id": "NP_009499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009499", "type": "external" } ], "gene_names_uniprotkb": "TOD6; PBF1; YBL0509; YBL0513", "gene_names_refseq": "PBF1; TOD6", "protein_names_uniprotkb": "Transcriptional regulatory protein TOD6; PAC-binding factor 1; Twin of DOT6", "protein_names_refseq": "Tod6p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL054W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "14562095;14562106;16544271;17322287;17330950;18407956;19040720;19111667;19158363;19684113;19779198;21177495;23749301;24374639;28270554;30516470;31208443;32597660;33481703;33491328;7813418;8154187", "class_list": "", "function": "Component of the RPD3 histone deacetylase complex RPD3C(L) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. TOD6 binds to sequences containing the core CGATG, which resembles the PAC (Polymerase A and C) motif., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 35, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VPU6", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0070210 Rpd3L-Expanded complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P34219-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34221-1", "uniprot_id": [ { "id": "PP2C3_YEAST", "url": "https://www.uniprot.org/uniprot/P34221", "type": "external" } ], "mass": 51332.0, "length": 468, "protein_name": "Protein phosphatase 2C homolog 3", "gene_name": "PTC3", "organism": "Yeast", "refseq_name": "type 2C protein phosphatase PTC3", "refseq_ac": [ { "id": "NP_009497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009497", "type": "external" } ], "gene_names_uniprotkb": "PTC3; YBL0511; YBL0513", "gene_names_refseq": "PTC3", "protein_names_uniprotkb": "Protein phosphatase 2C homolog 3; 3.1.3.16; PP2C-3", "protein_names_refseq": "type 2C protein phosphatase PTC3", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL056W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10580002;12477803;12667463;14562095;14562106;17322287;17330950;19779198;19795423;19823750;24374639;30655342;33481703;33491328;7813418;8154187", "class_list": "", "function": "Dephosphorylating regulator for many key proteins (PubMed:10580002, PubMed:12477803, PubMed:12667463). Dephosphorylates the cell cycle master regulator CDC28/cyclin-dependent kinase 1; its activity appears redundant with phosphatase PTC2 (PubMed:10580002). Dephosphorylates HOG1 at 'Thr-171', to attenuate activation of the stress-activated p38MAPK cascade; its activity appears redundant with phosphatase PTC2 (PubMed:12477803). Positively regulates both nonselective macroautophagy as well as the selective cytoplasm-to-vacuole (cvt) autophagy pathway and the genotoxin-induced targeted autophagy (GTA) pathway, possibly by dephosphorylating ATG13 to enable the interaction between the ATG17-ATG29-ATG31 and ATG1-ATG13 complexes; its activity appears redundant with phosphatase PTC2 (PubMed:30655342). Dephosphorylates RAD53, to regulate DNA damage checkpoint signaling (PubMed:12667463)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VPU4;Q92330", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.43", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0010508 positive regulation of autophagy;GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity;GO:1903753 negative regulation of p38MAPK cascade;GO:1904289 regulation of mitotic DNA damage checkpoint", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P34221-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34222-1", "uniprot_id": [ { "id": "PTH2_YEAST", "url": "https://www.uniprot.org/uniprot/P34222", "type": "external" } ], "mass": 22435.0, "length": 208, "protein_name": "Peptidyl-tRNA hydrolase 2", "gene_name": "PTH2", "organism": "Yeast", "refseq_name": "aminoacyl-tRNA hydrolase", "refseq_ac": [ { "id": "NP_009496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009496", "type": "external" } ], "gene_names_uniprotkb": "PTH2; YBL0510; YBL0514", "gene_names_refseq": "PTH2", "protein_names_uniprotkb": "Peptidyl-tRNA hydrolase 2; 3.1.1.29; PTH 2", "protein_names_refseq": "aminoacyl-tRNA hydrolase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL057C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12475929;12799450;14557538;14562106;17322287;22106047;23749301;24374639;33491328;7813418;8154187", "class_list": "", "function": "The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPU3", "ec_number_list": [ { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" } ], "go_molecular_function": "GO:0004045 peptidyl-tRNA hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P34222-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34225-1", "uniprot_id": [ { "id": "YEL1_YEAST", "url": "https://www.uniprot.org/uniprot/P34225", "type": "external" } ], "mass": 78768.0, "length": 687, "protein_name": "Guanine-nucleotide exchange factor YEL1", "gene_name": "YEL1", "organism": "Yeast", "refseq_name": "Arf family guanine nucleotide exchange factor YEL1", "refseq_ac": [ { "id": "NP_009493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009493", "type": "external" } ], "gene_names_uniprotkb": "YEL1; YBL0507; YBL0517", "gene_names_refseq": "YEL1", "protein_names_uniprotkb": "Guanine-nucleotide exchange factor YEL1; EFA6-like protein 1", "protein_names_refseq": "Arf family guanine nucleotide exchange factor YEL1", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL060W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562095;17330950;17563356;17786213;18208507;18397879;18407956;19779198;21126336;23749301;24374639;24440502;32597660;33481703;33491328;7813418;8154187", "class_list": "", "function": "Guanine-nucleotide exchange factor for ARF3 required for localization of ARF3 to the bud neck and tip and involved in actin patch polarization., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPT9", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005934 cellular bud tip;GO:0005935 cellular bud neck", "go_biological_process": "GO:0010513 positive regulation of phosphatidylinositol biosynthetic process;GO:0008104 intracellular protein localization;GO:0051666 actin cortical patch localization;GO:0032012 regulation of ARF protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P34225-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34226-1", "uniprot_id": [ { "id": "SKT5_YEAST", "url": "https://www.uniprot.org/uniprot/P34226", "type": "external" } ], "mass": 77066.0, "length": 696, "protein_name": "Chitin synthase regulator SKT5", "gene_name": "SKT5", "organism": "Yeast", "refseq_name": "Skt5p", "refseq_ac": [ { "id": "NP_009492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009492", "type": "external" } ], "gene_names_uniprotkb": "SKT5; CAL2; CHS4; CSD4; YBL0506; YBL0519", "gene_names_refseq": "CAL2; CHS4; CSD4; SKT5", "protein_names_uniprotkb": "Chitin synthase regulator SKT5", "protein_names_refseq": "Skt5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL061C)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "14562106;17142567;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;21177495;23749301;24374639;29763674;30516470;32597660;33481703;33491328;33502312;34965436;7764021;7813418;8154187;9234668;9314530", "class_list": "", "function": "Activator of the chitin synthase CHS3 which polymerizes chitin, a structural polymer of the fungal cell wall., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 45, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPT8;Q02215", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0000131 incipient cellular bud site;GO:0005935 cellular bud neck", "go_biological_process": "GO:0006031 chitin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P34226-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34227-1", "uniprot_id": [ { "id": "PRX1_YEAST", "url": "https://www.uniprot.org/uniprot/P34227", "type": "external" } ], "mass": 29496.0, "length": 261, "protein_name": "Peroxiredoxin PRX1, mitochondrial", "gene_name": "PRX1", "organism": "Yeast", "refseq_name": "thioredoxin peroxidase PRX1", "refseq_ac": [ { "id": "NP_009489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009489", "type": "external" } ], "gene_names_uniprotkb": "PRX1; YBL0503; YBL0524", "gene_names_refseq": "PRX1", "protein_names_uniprotkb": "Peroxiredoxin PRX1, mitochondrial; 1-Cys PRX; 1.11.1.25; 1.11.1.27; Glutaredoxin-dependent peroxiredoxin; Glutathione-dependent peroxiredoxin; Mitochondrial thiol peroxidase; Prx; Thioredoxin peroxidase; mTPx", "protein_names_refseq": "thioredoxin peroxidase PRX1", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL064C); (R-SCE-6798695)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10681558;10821871;14562106;14576278;17761666;19332553;20059400;21177495;24374639;33491328;7813418;8154187", "class_list": "", "function": "Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Involved in mitochondrial protection of cadmium-induced oxidative stress., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPT6", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.11.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.25", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" } ], "go_molecular_function": "GO:0008379 thioredoxin peroxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P34227-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34233-1", "uniprot_id": [ { "id": "ASH1_YEAST", "url": "https://www.uniprot.org/uniprot/P34233", "type": "external" } ], "mass": 65685.0, "length": 588, "protein_name": "Transcriptional regulatory protein ASH1", "gene_name": "ASH1", "organism": "Yeast", "refseq_name": "DNA-binding transcription repressor ASH1", "refseq_ac": [ { "id": "NP_012736", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012736", "type": "external" } ], "gene_names_uniprotkb": "ASH1", "gene_names_refseq": "ASH1", "protein_names_uniprotkb": "Transcriptional regulatory protein ASH1; Daughter cells HO repressor protein", "protein_names_refseq": "DNA-binding transcription repressor ASH1", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL185W)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "11171979;14562095;14562106;16314178;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21098119;21177495;23749301;24374639;24909858;27807972;30516470;32597660;33481703;33491328;8154185;8196765;8625408;8625409;9219698;9288973;9566907;9809065", "class_list": "", "function": "Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. ASH1 is necessary to repress HO in daughter cells to block mating-type switching through its binding to HO promoter 5'-YTGAT-3' sites. Also involved in pseudohyphal growth., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 39, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VX15", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0070210 Rpd3L-Expanded complex;GO:0005933 cellular bud;GO:0033698 Rpd3L complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization;GO:1900461 positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter;GO:0031495 negative regulation of mating type switching", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P34233-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34244-1", "uniprot_id": [ { "id": "HSL1_YEAST", "url": "https://www.uniprot.org/uniprot/P34244", "type": "external" } ], "mass": 169607.0, "length": 1518, "protein_name": "Probable serine/threonine-protein kinase HSL1", "gene_name": "HSL1", "organism": "Yeast", "refseq_name": "protein kinase HSL1", "refseq_ac": [ { "id": "NP_012821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012821", "type": "external" } ], "gene_names_uniprotkb": "HSL1; YKL453", "gene_names_refseq": "ELM2; HSL1; NIK1", "protein_names_uniprotkb": "Probable serine/threonine-protein kinase HSL1; 2.7.11.1", "protein_names_refseq": "protein kinase HSL1", "tax_id": 559292, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (sce:YKL101W)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "14562095;16688223;17287358;17563356;18407956;18768748;19211841;19684113;19779198;19795423;19823750;20489023;20702584;21126336;21177495;21725298;23749301;24374639;32597660;33481703;33491328;8196765;8256524;8647431", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 116, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2NP40;D6VXI6", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000144 cellular bud neck septin ring;GO:0005935 cellular bud neck", "go_biological_process": "GO:0000086 G2/M transition of mitotic cell cycle;GO:0030163 protein catabolic process;GO:0051726 regulation of cell cycle;GO:0044879 mitotic morphogenesis checkpoint signaling;GO:1902935 protein localization to septin ring", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P34244-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34247-1", "uniprot_id": [ { "id": "UTP11_YEAST", "url": "https://www.uniprot.org/uniprot/P34247", "type": "external" } ], "mass": 29735.0, "length": 250, "protein_name": "U3 small nucleolar RNA-associated protein 11", "gene_name": "UTP11", "organism": "Yeast", "refseq_name": "rRNA-processing protein UTP11", "refseq_ac": [ { "id": "NP_012823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012823", "type": "external" } ], "gene_names_uniprotkb": "UTP11; YKL449", "gene_names_refseq": "UTP11", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 11; U three protein 11; U3 snoRNA-associated protein 11", "protein_names_refseq": "rRNA-processing protein UTP11", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL099C); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12068309;12748633;15078877;17804645;24374639;33481703;33491328;8196765;8256524", "class_list": "", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXI8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005732 sno(s)RNA-containing ribonucleoprotein complex;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006412 translation;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P34247-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34252-1", "uniprot_id": [ { "id": "SLD2_YEAST", "url": "https://www.uniprot.org/uniprot/P34252", "type": "external" } ], "mass": 52272.0, "length": 453, "protein_name": "DNA replication regulator SLD2", "gene_name": "SLD2", "organism": "Yeast", "refseq_name": "Sld2p", "refseq_ac": [ { "id": "NP_012814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012814", "type": "external" } ], "gene_names_uniprotkb": "SLD2; DRC1; YKL463", "gene_names_refseq": "DRC1; SLD2", "protein_names_uniprotkb": "DNA replication regulator SLD2; DNA replication and checkpoint protein 1", "protein_names_refseq": "Sld2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL108W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10097122;11807498;14562106;14574415;16619031;17116692;17167417;19795423;19823750;20485558;21177495;23749301;24374639;32597660;33481703;33491328;34088668;8109175;8196765;9742127", "class_list": "", "function": "Has a role in the initiation of DNA replication. Required at S-phase checkpoint. Also required for the proper activation of RAD53 in response to DNA damage and replication blocks., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VXH9", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0031261 DNA replication preinitiation complex;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0071163 DNA replication preinitiation complex assembly;GO:1902977 mitotic DNA replication preinitiation complex assembly;GO:0031333 negative regulation of protein-containing complex assembly;GO:0006270 DNA replication initiation;GO:0000727 double-strand break repair via break-induced replication", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P34252-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34756-1", "uniprot_id": [ { "id": "FAB1_YEAST", "url": "https://www.uniprot.org/uniprot/P34756", "type": "external" } ], "mass": 257420.0, "length": 2278, "protein_name": "1-phosphatidylinositol 3-phosphate 5-kinase FAB1", "gene_name": "FAB1", "organism": "Yeast", "refseq_name": "1-phosphatidylinositol-3-phosphate 5-kinase", "refseq_ac": [ { "id": "NP_116674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116674", "type": "external" } ], "gene_names_uniprotkb": "FAB1; SVL7", "gene_names_refseq": "FAB1; SVL7", "protein_names_uniprotkb": "1-phosphatidylinositol 3-phosphate 5-kinase FAB1; 2.7.1.150; Formation of aploid and binucleate cells protein 1; PIPkin-III; Phosphatidylinositol 3-phosphate 5-kinase; Styryl dye vacuolar localization protein 7; Type III PIP kinase", "protein_names_refseq": "1-phosphatidylinositol-3-phosphate 5-kinase", "tax_id": 559292, "disease": "Fleck corneal dystrophy (Disease Ontology:DOID:0060448); cataract (Disease Ontology:DOID:83); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (sce:YFR019W)", "pathway_count": 1, "publication_count": 31, "publication_id_list": "11889142;11950935;14562095;14562106;15665377;16492811;17563356;18407956;18653468;19037259;19779198;19795423;19823750;21126336;22814378;23749301;24374639;28148651;28637746;30427760;32597660;33157024;33229814;33481703;33491328;34965436;7663021;7670463;9751732;9763421;9811604", "class_list": "", "function": "The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate (PubMed:16492811, PubMed:9811604). Required for endocytic-vacuolar pathway and nuclear migration (PubMed:16492811, PubMed:9751732, PubMed:9811604). The product of the reaction, PI(3,5)P2 is an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole (PubMed:9763421, PubMed:9811604). PI(3,5)P2 regulates the transition between trans-SNARE complex formation and vacuole membrane fusion (PubMed:30427760). Hyperosmotic shock-induced increase in the levels of PtdIns(3,5)P2 requires the presence of VAC7, VAC14, and/or FIG4 (PubMed:16492811)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 18, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 18, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 18, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 69, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "D6VTQ0", "ec_number_list": [ { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0010008 endosome membrane;GO:0070772 PAS complex;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0007033 vacuole organization;GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:1903100 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process;GO:0010511 regulation of phosphatidylinositol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 5.1, "record_id": "P34756-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34758-1", "uniprot_id": [ { "id": "SCD5_YEAST", "url": "https://www.uniprot.org/uniprot/P34758", "type": "external" } ], "mass": 97305.0, "length": 872, "protein_name": "Protein SCD5", "gene_name": "SCD5", "organism": "Yeast", "refseq_name": "Scd5p", "refseq_ac": [ { "id": "NP_014974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014974", "type": "external" } ], "gene_names_uniprotkb": "SCD5; FTB1", "gene_names_refseq": "FTB1; SCD5; SCD7", "protein_names_uniprotkb": "Protein SCD5; Protein FTB1", "protein_names_refseq": "Scd5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR329C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12356757;12956961;13679512;14562106;17563356;17898076;18407956;19779198;23749301;24374639;32597660;33229814;33481703;33491328;8688556;8896263;9169874", "class_list": "", "function": "Regulates both fluid phase and receptor-mediated endocytosis (PubMed:12356757, PubMed:12956961). Involved in vesicular transport at a late stage of the secretory pathway (PubMed:8688556). Regulates actin cytoskeleton organization (PubMed:12356757, PubMed:12956961)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W326", "ec_number_list": [], "go_molecular_function": "GO:0008157 protein phosphatase 1 binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane;GO:0030479 actin cortical patch", "go_biological_process": "GO:0006897 endocytosis;GO:0030866 cortical actin cytoskeleton organization;GO:0009306 protein secretion;GO:2000370 positive regulation of clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P34758-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34760-1", "uniprot_id": [ { "id": "TSA1_YEAST", "url": "https://www.uniprot.org/uniprot/P34760", "type": "external" } ], "mass": 21590.0, "length": 196, "protein_name": "Peroxiredoxin TSA1", "gene_name": "TSA1", "organism": "Yeast", "refseq_name": "thioredoxin peroxidase TSA1", "refseq_ac": [ { "id": "NP_013684", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013684", "type": "external" } ], "gene_names_uniprotkb": "TSA1; TPX1; TSA; ZRG14", "gene_names_refseq": "TPX1; TSA1; ZRG14", "protein_names_uniprotkb": "Peroxiredoxin TSA1; 1.11.1.24; Cytoplasmic thiol peroxidase 1; PRP; Protector protein; Prx; TPx type Ia; Thiol-specific antioxidant protein 1; Thioredoxin peroxidase type Ia; Thioredoxin-dependent peroxide reductase; Thioredoxin-dependent peroxiredoxin TSA1; cTPx 1", "protein_names_refseq": "thioredoxin peroxidase TSA1", "tax_id": 559292, "disease": "methylmalonic aciduria and homocystinuria type cblC (Disease Ontology:DOID:0050715); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); autosomal recessive spinocerebellar ataxia 32 (Disease Ontology:DOID:0070413); glucose intolerance (Disease Ontology:DOID:10603); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YML028W); (R-SCE-5628897); (R-SCE-6798695); (R-SCE-9818027)", "pathway_count": 4, "publication_count": 29, "publication_id_list": "10681558;14562106;14586471;15163410;15210711;15706081;18271751;18407956;19106090;19779198;19795423;19823750;21126336;21177495;22106047;22985967;23749301;24374639;24424024;27821475;2895105;32597660;33481703;33491328;7961686;8041739;8344960;9169872;9888818", "class_list": "", "function": "Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events (PubMed:10681558, PubMed:15210711, PubMed:19106090, PubMed:2895105, PubMed:7961686). Protects the cell against the oxidative stress caused by nascent-protein misfolding and aggregation (PubMed:24424024). Relays hydrogen peroxide as a signal to the transcription factor YAP1 by inducing the formation of intramolecular disulfide bonds in YAP1, which causes its nuclear accumulation and activation (PubMed:15706081, PubMed:19106090). Can act alternatively as peroxidase and molecular chaperone. Oxidative stress and heat shock exposure cause a reversible shift of the protein structure from low MW species to high MW complexes, triggering a peroxidase-to-chaperone functional switch. The chaperone function of the protein enhances resistance to heat shock (PubMed:15163410)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZE6", "ec_number_list": [ { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.4.23.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.25", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.8.98.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.98.2", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.7.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.59", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.3.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051082 unfolded protein binding;GO:0043022 ribosome binding;GO:0051920 peroxiredoxin activity;GO:0008379 thioredoxin peroxidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0034605 cellular response to heat;GO:0042262 DNA protection;GO:0050821 protein stabilization;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P34760-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34761-1", "uniprot_id": [ { "id": "WHI3_YEAST", "url": "https://www.uniprot.org/uniprot/P34761", "type": "external" } ], "mass": 71253.0, "length": 661, "protein_name": "Protein WHI3", "gene_name": "WHI3", "organism": "Yeast", "refseq_name": "mRNA-binding protein WHI3", "refseq_ac": [ { "id": "NP_014202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014202", "type": "external" } ], "gene_names_uniprotkb": "WHI3; N1382", "gene_names_refseq": "WHI3", "protein_names_uniprotkb": "Protein WHI3", "protein_names_refseq": "mRNA-binding protein WHI3", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL197C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11290704;14562106;17287358;18407956;19779198;20702584;21177495;23471970;23749301;24096659;24374639;32597660;33229814;33481703;33491328;7725799;9169873", "class_list": "", "function": "Involved in size control and cell cycle., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "D6W0Z0", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0010811 positive regulation of cell-substrate adhesion;GO:0045727 positive regulation of translation;GO:0045793 positive regulation of cell size;GO:0061157 mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P34761-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35056-1", "uniprot_id": [ { "id": "PEX5_YEAST", "url": "https://www.uniprot.org/uniprot/P35056", "type": "external" } ], "mass": 69324.0, "length": 612, "protein_name": "Peroxisomal targeting signal receptor", "gene_name": "PEX5", "organism": "Yeast", "refseq_name": "Pex5p", "refseq_ac": [ { "id": "NP_010530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010530", "type": "external" } ], "gene_names_uniprotkb": "PEX5; PAS10; YD8419.11", "gene_names_refseq": "PAS10; PEX5", "protein_names_uniprotkb": "Peroxisomal targeting signal receptor; PTS1 receptor; PTS1R; Peroxin-5", "protein_names_refseq": "Pex5p", "tax_id": 559292, "disease": "peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); peroxisome biogenesis disorder 2A (Disease Ontology:DOID:0080477); peroxisome biogenesis disorder 2B (Disease Ontology:DOID:0080622); rhizomelic chondrodysplasia punctata type 5 (Disease Ontology:DOID:0110854)", "pathway": " (sce:YDR244W); (R-SCE-9033241); (R-SCE-9664873)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "14562106;15283676;15536088;15632140;17322287;17452527;17550898;18407956;20154681;21665945;24374639;33481703;33491328;35768507;36122347;7980572;8265627;9094717;9169867", "class_list": "", "function": "Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) (PubMed:14562106, PubMed:35768507, PubMed:7980572, PubMed:8265627). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins (PubMed:9094717). PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle (PubMed:35768507)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSM4", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0005052 peroxisome matrix targeting signal-1 binding;GO:0140597 protein carrier chaperone", "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005782 peroxisomal matrix;GO:0005829 cytosol", "go_biological_process": "GO:0016558 protein import into peroxisome matrix;GO:0016560 protein import into peroxisome matrix, docking", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P35056-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35177-1", "uniprot_id": [ { "id": "SPT7_YEAST", "url": "https://www.uniprot.org/uniprot/P35177", "type": "external" } ], "mass": 152617.0, "length": 1332, "protein_name": "SAGA complex subunit SPT7", "gene_name": "SPT7", "organism": "Yeast", "refseq_name": "SAGA histone acetyltransferase complex subunit SPT7", "refseq_ac": [ { "id": "NP_009637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009637", "type": "external" } ], "gene_names_uniprotkb": "SPT7; YBR0739", "gene_names_refseq": "GIT2; SPT7", "protein_names_uniprotkb": "SAGA complex subunit SPT7; Suppressor of Ty protein 7; Transcriptional activator SPT7", "protein_names_refseq": "SAGA histone acetyltransferase complex subunit SPT7", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR081C)", "pathway_count": 1, "publication_count": 36, "publication_id_list": "10026213;10864329;12101232;12186975;12446794;1350857;14562106;15260971;15647753;17330950;17563356;18407956;19779198;20190278;20489023;20498363;21126336;23749301;24374639;25216679;28918903;30516470;31969703;32051285;32597660;33481703;33491328;33864814;7713415;7813418;7985423;9224714;9674426;9756893;9858534;9885573", "class_list": "", "function": "Component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription (PubMed:10864329, PubMed:25216679, PubMed:28918903). At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module) (PubMed:31969703, PubMed:9858534). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B (PubMed:10026213). SAGA interacts with DNA via upstream activating sequences (UASs) (PubMed:28918903). Also identified in a modified version of SAGA named SALSA or SLIK (PubMed:12101232, PubMed:12186975, PubMed:12446794). The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities (PubMed:33864814)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 34, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ80", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0000124 SAGA complex;GO:0046695 SLIK (SAGA-like) complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:0065003 protein-containing complex assembly;GO:0000747 conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P35177-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35179-1", "uniprot_id": [ { "id": "SC61G_YEAST", "url": "https://www.uniprot.org/uniprot/P35179", "type": "external" } ], "mass": 8944.0, "length": 80, "protein_name": "Protein transport protein SSS1", "gene_name": "SSS1", "organism": "Yeast", "refseq_name": "translocon subunit SSS1", "refseq_ac": [ { "id": "NP_010371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010371", "type": "external" } ], "gene_names_uniprotkb": "SSS1; D4475", "gene_names_refseq": "SSS1", "protein_names_uniprotkb": "Protein transport protein SSS1; Sec61 complex subunit SSS1; Sec61 complex subunit gamma; Ssh1 complex subunit SSS1; Ssh1 complex subunit gamma", "protein_names_refseq": "translocon subunit SSS1", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YDR086C); (R-SCE-9609523)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10611978;10775273;14562095;15831493;17322287;19795423;19823750;21126336;24374639;32597660;33491328;8223425;8929540;9160745;9169867", "class_list": "", "function": "Part of the Sec61 complex, which is the major component of channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). The functional states of the translocon complex include co- and post-translational ER import, cotranslational membrane protein integration and retrograde transport of misfolded proteins out of the ER. In the cotranslational pathway, ribosomes synthesizing presecretory proteins are targeted to the translocon by the cytosolic signal recognition particle (SRP) and its ER-localized receptor. The association of the Sec61 complex with the ribosome is mediated by the 28S rRNA of the large ribosomal subunit. SRP-independent post-translational translocation requires the association of additional factors, such as the Sec62/63 complex and KAR2. Also part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein ER import., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS73", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005784 Sec61 translocon complex;GO:0005637 nuclear inner membrane;GO:0030867 rough endoplasmic reticulum membrane", "go_biological_process": "GO:0006614 SRP-dependent cotranslational protein targeting to membrane;GO:0031204 post-translational protein targeting to membrane, translocation;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P35179-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35181-1", "uniprot_id": [ { "id": "AP1S1_YEAST", "url": "https://www.uniprot.org/uniprot/P35181", "type": "external" } ], "mass": 18152.0, "length": 156, "protein_name": "AP-1 complex subunit sigma-1", "gene_name": "APS1", "organism": "Yeast", "refseq_name": "Aps1p", "refseq_ac": [ { "id": "NP_013271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013271", "type": "external" } ], "gene_names_uniprotkb": "APS1; L9470.16; YAP19", "gene_names_refseq": "APS1; YAP19", "protein_names_uniprotkb": "AP-1 complex subunit sigma-1; Clathrin assembly protein complex 1 sigma-1 small chain; Clathrin coat assembly protein AP19; Clathrin coat-associated protein AP19; Golgi adaptor AP-1 19 kDa adaptin; HA1 19 kDa subunit; Sigma1-adaptin", "protein_names_refseq": "Aps1p", "tax_id": 559292, "disease": "MEDNIK syndrome (Disease Ontology:DOID:0060483); syndromic X-linked intellectual disability 5 (Disease Ontology:DOID:0060800); psoriasis 15 (Disease Ontology:DOID:0111281)", "pathway": " (sce:YLR170C); (R-SCE-432720)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10564262;14562106;17322287;24374639;26658609;33491328;8157009;8373805;9169871", "class_list": "", "function": "Component of the adapter complexes which link clathrin to receptors in coated vesicles (PubMed:10564262). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (PubMed:10564262). AP19 is probably a subunit of the Golgi membrane adapter (PubMed:10564262). Component of the AP-1-related (AP-1R) complex, an adapter protein complex that mediates sorting of cargo SNARE SNC1 (PubMed:26658609). In contrast to the APM1-containing AP-1 complex, AP-1R is incapable of sorting CHS3 (PubMed:26658609)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYH5", "ec_number_list": [], "go_molecular_function": "GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005768 endosome;GO:0005829 cytosol;GO:0030121 AP-1 adaptor complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0048203 vesicle targeting, trans-Golgi to endosome;GO:0006896 Golgi to vacuole transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P35181-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35182-1", "uniprot_id": [ { "id": "PP2C1_YEAST", "url": "https://www.uniprot.org/uniprot/P35182", "type": "external" } ], "mass": 31550.0, "length": 281, "protein_name": "Protein phosphatase 2C homolog 1", "gene_name": "PTC1", "organism": "Yeast", "refseq_name": "type 2C protein phosphatase PTC1", "refseq_ac": [ { "id": "NP_010278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010278", "type": "external" } ], "gene_names_uniprotkb": "PTC1; D2925; TPD1", "gene_names_refseq": "CWH47; KCS2; PTC1; TPD1", "protein_names_uniprotkb": "Protein phosphatase 2C homolog 1; 3.1.3.16; PP2C-1", "protein_names_refseq": "type 2C protein phosphatase PTC1", "tax_id": 559292, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (sce:YDL006W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562106;14685261;19779198;23749301;24374639;33481703;33491328;35563734;8196609;8395005;9169867", "class_list": "", "function": "Serine and threonine phosphatase (PubMed:8196609, PubMed:8395005). Involved in tRNA splicing and cell separation (PubMed:8196609)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRY2", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.43", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:1990439 MAP kinase serine/threonine phosphatase activity;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome", "go_biological_process": "GO:0007165 signal transduction;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0043409 negative regulation of MAPK cascade;GO:0000001 mitochondrion inheritance;GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P35182-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35191-1", "uniprot_id": [ { "id": "MDJ1_YEAST", "url": "https://www.uniprot.org/uniprot/P35191", "type": "external" } ], "mass": 55561.0, "length": 511, "protein_name": "DnaJ homolog 1, mitochondrial", "gene_name": "MDJ1", "organism": "Yeast", "refseq_name": "Mdj1p", "refseq_ac": [ { "id": "NP_116638", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116638", "type": "external" } ], "gene_names_uniprotkb": "MDJ1", "gene_names_refseq": "MDJ1", "protein_names_uniprotkb": "DnaJ homolog 1, mitochondrial", "protein_names_refseq": "Mdj1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YFL016C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;24374639;33491328;7670463;8168133;9353316", "class_list": "", "function": "Plays a role in mitochondrial biogenesis and protein folding., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTL4", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0051082 unfolded protein binding;GO:0031072 heat shock protein binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0009408 response to heat;GO:0042026 protein refolding;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins;GO:0006458 'de novo' protein folding", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P35191-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35192-1", "uniprot_id": [ { "id": "MAC1_YEAST", "url": "https://www.uniprot.org/uniprot/P35192", "type": "external" } ], "mass": 46516.0, "length": 417, "protein_name": "Metal-binding activator 1", "gene_name": "MAC1", "organism": "Yeast", "refseq_name": "Mac1p", "refseq_ac": [ { "id": "NP_013734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013734", "type": "external" } ], "gene_names_uniprotkb": "MAC1; CUA1; YM9711.11C", "gene_names_refseq": "CUA1; MAC1", "protein_names_uniprotkb": "Metal-binding activator 1", "protein_names_refseq": "Mac1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR021C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11134042;12011036;14562106;17322287;18407956;20702584;21126336;23749301;24374639;32597660;33481703;33491328;8262047;9169872", "class_list": "", "function": "Regulatory protein involved in Cu/Fe utilization and stress resistance. Involved in basal level transcription of FRE1 and H(2)O(2)-induced transcription of CTT1. Regulates the transcription of CTR1 and CTR3 via the copper ion responsive elements in their promoters. Required for degradation of CTR1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZJ5;E9P8Z5", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0005507 copper ion binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006878 intracellular copper ion homeostasis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006879 intracellular iron ion homeostasis;GO:0045732 positive regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P35192-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35194-1", "uniprot_id": [ { "id": "UTP20_YEAST", "url": "https://www.uniprot.org/uniprot/P35194", "type": "external" } ], "mass": 287560.0, "length": 2493, "protein_name": "U3 small nucleolar RNA-associated protein 20", "gene_name": "UTP20", "organism": "Yeast", "refseq_name": "Utp20p", "refseq_ac": [ { "id": "NP_009551", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009551", "type": "external" } ], "gene_names_uniprotkb": "UTP20; YBL0101", "gene_names_refseq": "UTP20", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 20; U three protein 20; U3 snoRNA-associated protein 20", "protein_names_refseq": "Utp20p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL004W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14562095;15590835;17563356;23749301;24374639;32597660;33491328;7813418;8091860", "class_list": "", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VPZ8", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030688 preribosome, small subunit precursor;GO:0030686 90S preribosome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P35194-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35196-1", "uniprot_id": [ { "id": "RER2_YEAST", "url": "https://www.uniprot.org/uniprot/P35196", "type": "external" } ], "mass": 32694.0, "length": 286, "protein_name": "Dehydrodolichyl diphosphate synthase complex subunit RER2", "gene_name": "RER2", "organism": "Yeast", "refseq_name": "ditrans,polycis-polyprenyl diphosphate synthase", "refseq_ac": [ { "id": "NP_009556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009556", "type": "external" } ], "gene_names_uniprotkb": "RER2; YBR0107", "gene_names_refseq": "RER2", "protein_names_uniprotkb": "Dehydrodolichyl diphosphate synthase complex subunit RER2; 2.5.1.87; DEDOL-PP synthase; Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific)", "protein_names_refseq": "ditrans,polycis-polyprenyl diphosphate synthase", "tax_id": 559292, "disease": "developmental delay and seizures with or without movement abnormalities (Disease Ontology:DOID:0080473); retinitis pigmentosa 59 (Disease Ontology:DOID:0110352); cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YBR002C); (R-SCE-446199)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11442630;14562106;17345630;24374639;25066056;33491328;7813418;8091860;9858571", "class_list": "", "function": "With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ03", "ec_number_list": [ { "id": "2.5.1.87", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.87", "type": "external" } ], "go_molecular_function": "GO:0004659 prenyltransferase activity;GO:0045547 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane;GO:1904423 dehydrodolichyl diphosphate synthase complex", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0043048 dolichyl monophosphate biosynthetic process;GO:0016094 polyprenol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P35196-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35197-1", "uniprot_id": [ { "id": "GCS1_YEAST", "url": "https://www.uniprot.org/uniprot/P35197", "type": "external" } ], "mass": 39296.0, "length": 352, "protein_name": "ADP-ribosylation factor GTPase-activating protein GCS1", "gene_name": "GCS1", "organism": "Yeast", "refseq_name": "GTPase-activating protein GCS1", "refseq_ac": [ { "id": "NP_010055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010055", "type": "external" } ], "gene_names_uniprotkb": "GCS1", "gene_names_refseq": "GCS1", "protein_names_uniprotkb": "ADP-ribosylation factor GTPase-activating protein GCS1; ARF GAP GCS1", "protein_names_refseq": "GTPase-activating protein GCS1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL226C); (R-SCE-6807878); (R-SCE-6811434)", "pathway_count": 3, "publication_count": 27, "publication_id_list": "11756474;11839779;11875433;14562106;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;27821475;31208443;32597660;33229814;33481703;33491328;34965436;8070409;9169867;9927415", "class_list": "", "function": "GTPase-activating protein (GAP) for ARF1 and ARF2. Involved in intracellular vesicular transport. Required for transport from the trans-Golgi network. Implicated in the regulation of retrograde transport from the Golgi to the ER and in actin cytoskeletal organization. May be involved in the maintenance of mitochondrial morphology, possibly through organizing the actin cytoskeleton in Saccharomyces., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 32, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VRC9", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0048205 COPI coating of Golgi vesicle;GO:0000278 mitotic cell cycle;GO:0007015 actin filament organization;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0043001 Golgi to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P35197-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35201-1", "uniprot_id": [ { "id": "CENPC_YEAST", "url": "https://www.uniprot.org/uniprot/P35201", "type": "external" } ], "mass": 62473.0, "length": 549, "protein_name": "Inner kinetochore subunit MIF2", "gene_name": "MIF2", "organism": "Yeast", "refseq_name": "Mif2p", "refseq_ac": [ { "id": "NP_012834", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012834", "type": "external" } ], "gene_names_uniprotkb": "MIF2", "gene_names_refseq": "MIF2", "protein_names_uniprotkb": "Inner kinetochore subunit MIF2; CENP-C homolog; Constitutive centromere-associated network protein MIF2; Mitotic fidelity of chromosome transmission protein 2", "protein_names_refseq": "Mif2p", "tax_id": 559292, "disease": "CREST syndrome (Disease Ontology:DOID:0060218); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (sce:YKL089W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "14562106;14581449;17330950;18407956;18701705;19779198;20489023;21126336;21633108;22218487;22561346;22814378;23749301;24374639;32597660;33481703;33491328;7579695;7628703;8196765;8408221", "class_list": "", "function": "Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (PubMed:22561346, PubMed:7579695, PubMed:8408221)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXJ9", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0019237 centromeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore;GO:0000779 condensed chromosome, centromeric region", "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051382 kinetochore assembly;GO:0051455 spindle attachment to meiosis I kinetochore;GO:0007059 chromosome segregation;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P35201-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35203-1", "uniprot_id": [ { "id": "CBF3C_YEAST", "url": "https://www.uniprot.org/uniprot/P35203", "type": "external" } ], "mass": 56336.0, "length": 478, "protein_name": "Centromere DNA-binding protein complex CBF3 subunit C", "gene_name": "CTF13", "organism": "Yeast", "refseq_name": "Ctf13p", "refseq_ac": [ { "id": "NP_013812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013812", "type": "external" } ], "gene_names_uniprotkb": "CTF13; CBF3C; YM6543.01; YM9582.19", "gene_names_refseq": "CTF13", "protein_names_uniprotkb": "Centromere DNA-binding protein complex CBF3 subunit C; Chromosome transmission fidelity protein 13; Kinetochore protein CTF13", "protein_names_refseq": "Ctf13p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR094W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15090617;19795423;19823750;24374639;33481703;33491328;7957085;8500169;9169872", "class_list": "", "function": "Acts as a central component of the centromere DNA-binding protein complex CBF3, which is essential for chromosome segregation and movement of centromeres along microtubules. CBF3 is required for the recruitment of other kinetochore complexes to CEN DNA. It plays a role in the attachment of chromosomes to the spindle and binds selectively to a highly conserved DNA sequence called CDEIII, found in centromers and in several promoters. The association of CBF3C with CBF3D and SGT1 is required for CBF3C activation and CBF3 assembly., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZR7", "ec_number_list": [], "go_molecular_function": "GO:0008301 DNA binding, bending", "go_cellular_component": "GO:0000776 kinetochore;GO:0031518 CBF3 complex", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0000921 septin ring assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P35203-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35206-1", "uniprot_id": [ { "id": "CSG2_YEAST", "url": "https://www.uniprot.org/uniprot/P35206", "type": "external" } ], "mass": 45442.0, "length": 410, "protein_name": "Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2", "gene_name": "CSG2", "organism": "Yeast", "refseq_name": "mannosylinositol phosphorylceramide synthase regulatory subunit", "refseq_ac": [ { "id": "NP_009592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009592", "type": "external" } ], "gene_names_uniprotkb": "CSG2; CLS2; YBR0404", "gene_names_refseq": "CLS2; CSG2", "protein_names_uniprotkb": "Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2", "protein_names_refseq": "mannosylinositol phosphorylceramide synthase regulatory subunit", "tax_id": 559292, "disease": "Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595)", "pathway": " (sce:YBR036C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12954640;16847258;23749301;24374639;2543907;7813418;7854312;8091864;8125941", "class_list": "", "function": "Required for calcium regulation. May regulate calcium accumulation by a non-vacuole organelle. Also regulates the activity of CSH1 and SUR1 during mannosyl phosphorylinositol ceramide synthesis., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ36", "ec_number_list": [], "go_molecular_function": "GO:0030234 enzyme regulator activity;GO:0015278 intracellularly gated calcium channel activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0006874 intracellular calcium ion homeostasis;GO:0032469 endoplasmic reticulum calcium ion homeostasis;GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum;GO:0006676 mannosyl diphosphorylinositol ceramide metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P35206-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35208-1", "uniprot_id": [ { "id": "SPT10_YEAST", "url": "https://www.uniprot.org/uniprot/P35208", "type": "external" } ], "mass": 72922.0, "length": 640, "protein_name": "Protein SPT10", "gene_name": "SPT10", "organism": "Yeast", "refseq_name": "Spt10p", "refseq_ac": [ { "id": "NP_012408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012408", "type": "external" } ], "gene_names_uniprotkb": "SPT10; CRE1; J0702; SUD1", "gene_names_refseq": "CRE1; SPT10; SUD1", "protein_names_uniprotkb": "Protein SPT10", "protein_names_refseq": "Spt10p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL127C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562106;19683497;23749301;24374639;33481703;33491328;8138180;8264536;8641269;8948101", "class_list": "", "function": "Required for normal transcription at a number of loci in yeast. Affects transcription at Ty1 elements, at PHO5, STE6 and ADH2., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VW59", "ec_number_list": [], "go_molecular_function": "GO:0043565 sequence-specific DNA binding;GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0010507 negative regulation of autophagy;GO:0000183 rDNA heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P35208-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35688-1", "uniprot_id": [ { "id": "LRG1_YEAST", "url": "https://www.uniprot.org/uniprot/P35688", "type": "external" } ], "mass": 116651.0, "length": 1017, "protein_name": "Rho-GTPase-activating protein LRG1", "gene_name": "LRG1", "organism": "Yeast", "refseq_name": "GTPase-activating protein LRG1", "refseq_ac": [ { "id": "NP_010041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010041", "type": "external" } ], "gene_names_uniprotkb": "LRG1", "gene_names_refseq": "LRG1", "protein_names_uniprotkb": "Rho-GTPase-activating protein LRG1; LIM-RhoGAP protein 1", "protein_names_refseq": "GTPase-activating protein LRG1", "tax_id": 559292, "disease": "hypertrophic cardiomyopathy 12 (Disease Ontology:DOID:0110318); dilated cardiomyopathy 1M (Disease Ontology:DOID:0110449); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (sce:YDL240W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11447600;11591390;14562095;14562106;18407956;19779198;22814378;23749301;24374639;33481703;33491328;8065929;9169867", "class_list": "", "function": "Acts in signal transduction. Activates CDC42, RHO1 and RHO2. Negatively regulates 1,3-beta-glucan synthesis. May be responsible for the down-regulation of CDC42 during mating., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRB6;Q07735", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0030427 site of polarized growth;GO:0000131 incipient cellular bud site;GO:0005934 cellular bud tip", "go_biological_process": "GO:0007165 signal transduction;GO:0030036 actin cytoskeleton organization;GO:0035024 negative regulation of Rho protein signal transduction;GO:0000755 cytogamy;GO:0030435 sporulation resulting in formation of a cellular spore", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P35688-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35691-1", "uniprot_id": [ { "id": "TCTP_YEAST", "url": "https://www.uniprot.org/uniprot/P35691", "type": "external" } ], "mass": 18741.0, "length": 167, "protein_name": "Translationally-controlled tumor protein homolog", "gene_name": "TMA19", "organism": "Yeast", "refseq_name": "Tma19p", "refseq_ac": [ { "id": "NP_012867", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012867", "type": "external" } ], "gene_names_uniprotkb": "TMA19; MMI1; YKL312", "gene_names_refseq": "MMI1; TMA19", "protein_names_uniprotkb": "Translationally-controlled tumor protein homolog; Microtubule and mitochondria-interacting protein 1; TCTP; Translation machinery-associated protein 19", "protein_names_refseq": "Tma19p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL056C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562095;14562106;16702403;16806052;19779198;19795423;19823750;23749301;24374639;30516470;33481703;33491328;8091862;8196765;9038161", "class_list": "", "function": "Involved in protein synthesis. Involved in microtubule stabilization., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXN1", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005874 microtubule;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0010507 negative regulation of autophagy;GO:0007026 negative regulation of microtubule depolymerization;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P35691-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35728-1", "uniprot_id": [ { "id": "MPE1_YEAST", "url": "https://www.uniprot.org/uniprot/P35728", "type": "external" } ], "mass": 49647.0, "length": 441, "protein_name": "Protein MPE1", "gene_name": "MPE1", "organism": "Yeast", "refseq_name": "cleavage polyadenylation factor subunit MPE1", "refseq_ac": [ { "id": "NP_012864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012864", "type": "external" } ], "gene_names_uniprotkb": "MPE1; YKL316", "gene_names_refseq": "MPE1", "protein_names_uniprotkb": "Protein MPE1", "protein_names_refseq": "cleavage polyadenylation factor subunit MPE1", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YKL059C); (R-SCE-983168)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12819204;14562106;17563356;18407956;24374639;33229814;33491328;8091862;8196765", "class_list": "", "function": "Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6VXM8", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0006369 termination of RNA polymerase II transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P35728-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35729-1", "uniprot_id": [ { "id": "NU120_YEAST", "url": "https://www.uniprot.org/uniprot/P35729", "type": "external" } ], "mass": 120448.0, "length": 1037, "protein_name": "Nucleoporin NUP120", "gene_name": "NUP120", "organism": "Yeast", "refseq_name": "Nup120p", "refseq_ac": [ { "id": "NP_012866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012866", "type": "external" } ], "gene_names_uniprotkb": "NUP120; RAT2; YKL313; YKL314", "gene_names_refseq": "NUP120; RAT2", "protein_names_uniprotkb": "Nucleoporin NUP120; Nuclear pore protein NUP120", "protein_names_refseq": "Nup120p", "tax_id": 559292, "disease": "nephrotic syndrome type 19 (Disease Ontology:DOID:0080394)", "pathway": " (sce:YKL057C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10684247;11071906;11823431;12730220;12791264;18407956;21177495;24374639;33491328;8091862;8196765;8557736;8557737;8565072", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP120 is involved in nuclear poly(A)+ RNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXN0;P35730", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0031509 subtelomeric heterochromatin formation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006406 mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P35729-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35732-1", "uniprot_id": [ { "id": "DEF1_YEAST", "url": "https://www.uniprot.org/uniprot/P35732", "type": "external" } ], "mass": 83973.0, "length": 738, "protein_name": "RNA polymerase II degradation factor 1", "gene_name": "DEF1", "organism": "Yeast", "refseq_name": "DNA damage-responsive RNA polymerase-degradation factor DEF1", "refseq_ac": [ { "id": "NP_012869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012869", "type": "external" } ], "gene_names_uniprotkb": "DEF1; RIP1; VID31; YKL308", "gene_names_refseq": "DEF1; VID31", "protein_names_uniprotkb": "RNA polymerase II degradation factor 1; RRM3-interacting protein 1", "protein_names_refseq": "DNA damage-responsive RNA polymerase-degradation factor DEF1", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL054C)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "11859374;14562106;15166235;15863512;15960978;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;23993092;24374639;24909858;27821475;32597660;33481703;33491328;8091862;8196765", "class_list": "", "function": "Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled repair (TCR) factor RAD26 fails to efficiently displace stalled RNA polymerase II (PubMed:11859374, PubMed:15166235, PubMed:15960978). Also involved in telomere length regulation (PubMed:15863512). Binds DNA (PubMed:15863512)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXN3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0043130 ubiquitin binding;GO:0062058 transcription factor TFIIH holo complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0000723 telomere maintenance;GO:0006974 DNA damage response;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P35732-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35817-1", "uniprot_id": [ { "id": "BDF1_YEAST", "url": "https://www.uniprot.org/uniprot/P35817", "type": "external" } ], "mass": 76978.0, "length": 686, "protein_name": "Bromodomain-containing factor 1", "gene_name": "BDF1", "organism": "Yeast", "refseq_name": "chromatin-binding protein BDF1", "refseq_ac": [ { "id": "NP_013503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013503", "type": "external" } ], "gene_names_uniprotkb": "BDF1; L8084.18", "gene_names_refseq": "BDF1", "protein_names_uniprotkb": "Bromodomain-containing factor 1", "protein_names_refseq": "chromatin-binding protein BDF1", "tax_id": 559292, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); Cornelia de Lange syndrome 6 (Disease Ontology:DOID:0060970); spermatogenic failure 21 (Disease Ontology:DOID:0070163); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); nephrocalcinosis (Disease Ontology:DOID:12679); azoospermia (Disease Ontology:DOID:14227); oligospermia (Disease Ontology:DOID:14228); melanoma (Disease Ontology:DOID:1909); colon cancer (Disease Ontology:DOID:219); transitional cell carcinoma (Disease Ontology:DOID:2671); photosensitivity disease (Disease Ontology:DOID:3159); papillary thyroid carcinoma (Disease Ontology:DOID:3969); juvenile myoclonic epilepsy (Disease Ontology:DOID:4890); B-cell lymphoma (Disease Ontology:DOID:707)", "pathway": " (sce:YLR399C)", "pathway_count": 1, "publication_count": 35, "publication_id_list": "10783167;11343701;12482937;12620224;12620225;14562095;14562106;15143168;15225549;15255905;15665377;16079223;17287358;17330950;17563356;18407956;19684113;19779198;20190278;20702584;21126336;21177495;22218487;23749301;24374639;24909858;30516470;32597660;33481703;33491328;7791775;7816623;8321235;9169871;9175470", "class_list": "", "function": "Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA-damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ34;Q06048", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0001094 TFIID-class transcription factor complex binding;GO:0001046 core promoter sequence-specific DNA binding;GO:0140566 histone reader activity;GO:0140008 histone H4 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0000812 Swr1 complex", "go_biological_process": "GO:0009301 snRNA transcription;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006355 regulation of DNA-templated transcription;GO:1905168 positive regulation of double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P35817-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35843-1", "uniprot_id": [ { "id": "HES1_YEAST", "url": "https://www.uniprot.org/uniprot/P35843", "type": "external" } ], "mass": 49505.0, "length": 434, "protein_name": "Oxysterol-binding protein homolog 5", "gene_name": "HES1", "organism": "Yeast", "refseq_name": "oxysterol-binding protein related protein HES1", "refseq_ac": [ { "id": "NP_014880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014880", "type": "external" } ], "gene_names_uniprotkb": "HES1; O5234; OSH5", "gene_names_refseq": "HES1; OSH5", "protein_names_uniprotkb": "Oxysterol-binding protein homolog 5; Homologous to KES1 protein 1; ORP 5; OSBP-related protein 5; Oxysterol-binding protein-related protein 5; Protein HES1", "protein_names_refseq": "oxysterol-binding protein related protein HES1", "tax_id": 559292, "disease": "autosomal dominant nonsyndromic deafness 67 (Disease Ontology:DOID:0110588); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (sce:YOR237W); (R-SCE-1482801); (R-SCE-192105)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11238399;14562106;15173322;16408938;16585271;20008566;24374639;26928762;8017104;8972580;9169874", "class_list": "", "function": "Lipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes. Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol. Involved in maintenance of intracellular sterol distribution and homeostasis. Plays a role in ergosterol synthesis (PubMed:11238399, PubMed:15173322, PubMed:16408938, PubMed:20008566). Binds and transports sterol (PubMed:20008566). May be involved in ergosterol transport from the plasma membrane (PM) to the ER (PubMed:16585271)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2U0", "ec_number_list": [], "go_molecular_function": "GO:0008142 oxysterol binding;GO:0008289 lipid binding;GO:0120015 sterol transfer activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0000329 fungal-type vacuole membrane;GO:0005935 cellular bud neck", "go_biological_process": "GO:0006897 endocytosis;GO:0016126 sterol biosynthetic process;GO:0006887 exocytosis;GO:0030011 maintenance of cell polarity;GO:0034727 piecemeal microautophagy of the nucleus", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P35843-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35845-1", "uniprot_id": [ { "id": "OSH1_YEAST", "url": "https://www.uniprot.org/uniprot/P35845", "type": "external" } ], "mass": 135098.0, "length": 1188, "protein_name": "Oxysterol-binding protein homolog 1", "gene_name": "SWH1", "organism": "Yeast", "refseq_name": "oxysterol-binding protein related protein SWH1", "refseq_ac": [ { "id": "NP_009421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009421", "type": "external" } ], "gene_names_uniprotkb": "SWH1; OSH1; YAR044W", "gene_names_refseq": "OSH1; SWH1; YAR044W", "protein_names_uniprotkb": "Oxysterol-binding protein homolog 1; ORP 1; OSBP-related protein 1; Oxysterol-binding protein-related protein 1", "protein_names_refseq": "oxysterol-binding protein related protein SWH1", "tax_id": 559292, "disease": "cholangiocarcinoma (Disease Ontology:DOID:4947); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YAR042W); (R-SCE-192105)", "pathway_count": 2, "publication_count": 32, "publication_id_list": "11238399;11408574;12727870;12844361;15023338;15173322;15367582;15665377;16096648;17287358;17330950;17563356;18407956;19779198;19795423;19823750;20008566;20702584;21126336;21177495;22218487;23749301;24374639;25420878;28319008;30516470;32597660;33481703;33491328;7731988;8017104;8086466", "class_list": "", "function": "Lipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes. Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol. Involved in maintenance of intracellular sterol distribution and homeostasis (PubMed:11238399, PubMed:15173322, PubMed:8017104). Involved in non-vesicular transport of ergosterol and PI(4)P at the NVJ. Binds sterol and PI4P in a mutually exclusive manner (PubMed:28319008). May be involved in formation of PMN vesicles by altering the membrane lipid composition (PubMed:15173322)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 45, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPN6;P39555;P80234;Q86ZC4;Q86ZS1", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0032934 sterol binding;GO:0120015 sterol transfer activity", "go_cellular_component": "GO:0071561 nucleus-vacuole junction;GO:0000139 Golgi membrane;GO:0005635 nuclear envelope;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006897 endocytosis;GO:0006887 exocytosis;GO:0030011 maintenance of cell polarity;GO:0034727 piecemeal microautophagy of the nucleus;GO:0015918 sterol transport", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P35845-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35997-1", "uniprot_id": [ { "id": "RS27A_YEAST", "url": "https://www.uniprot.org/uniprot/P35997", "type": "external" } ], "mass": 8879.0, "length": 82, "protein_name": "Small ribosomal subunit protein eS27A", "gene_name": "RPS27A", "organism": "Yeast", "refseq_name": "40S ribosomal protein eS27 RPS27A", "refseq_ac": [ { "id": "NP_012766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012766", "type": "external" } ], "gene_names_uniprotkb": "RPS27A", "gene_names_refseq": "RPS27A", "protein_names_uniprotkb": "Small ribosomal subunit protein eS27A; 40S ribosomal protein S27-A; RP61; YS20", "protein_names_refseq": "40S ribosomal protein eS27 RPS27A", "tax_id": 559292, "disease": "Diamond-Blackfan anemia 17 (Disease Ontology:DOID:0111880)", "pathway": " (sce:YKL156W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 12, "publication_count": 12, "publication_id_list": "10601260;14562095;14562106;20980660;22096102;22650761;24200810;24374639;24524803;8091859;8196765;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX42", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P35997-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35999-1", "uniprot_id": [ { "id": "PMIP_YEAST", "url": "https://www.uniprot.org/uniprot/P35999", "type": "external" } ], "mass": 88183.0, "length": 772, "protein_name": "Mitochondrial intermediate peptidase", "gene_name": "OCT1", "organism": "Yeast", "refseq_name": "metalloendopeptidase", "refseq_ac": [ { "id": "NP_012788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012788", "type": "external" } ], "gene_names_uniprotkb": "OCT1; MIP1", "gene_names_refseq": "OCT1", "protein_names_uniprotkb": "Mitochondrial intermediate peptidase; 3.4.24.59; MIP", "protein_names_refseq": "metalloendopeptidase", "tax_id": 559292, "disease": "combined oxidative phosphorylation deficiency 31 (Disease Ontology:DOID:0111488); lipodystrophy (Disease Ontology:DOID:811)", "pathway": " (sce:YKL134C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10332043;14562095;14562106;16823961;24374639;25176146;7593000;8035833;8196765;8831696", "class_list": "", "function": "Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane. Cleaves precursor proteins of respiratory components, including subunits of the electron transport chain and tricarboxylic acid cycle enzymes, and components of the mitochondrial genetic machinery, including ribosomal proteins, translation factors, and proteins required for mitochondrial DNA metabolism., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX62;P51980", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0050821 protein stabilization;GO:0006627 protein processing involved in protein targeting to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P35999-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36005-1", "uniprot_id": [ { "id": "KDX1_YEAST", "url": "https://www.uniprot.org/uniprot/P36005", "type": "external" } ], "mass": 49633.0, "length": 433, "protein_name": "Serine/threonine-protein kinase KDX1", "gene_name": "KDX1", "organism": "Yeast", "refseq_name": "putative protein kinase KDX1", "refseq_ac": [ { "id": "NP_012761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012761", "type": "external" } ], "gene_names_uniprotkb": "KDX1; MLP1; YKL615", "gene_names_refseq": "KDX1; MLP1", "protein_names_uniprotkb": "Serine/threonine-protein kinase KDX1; 2.7.11.1; Kinase dead X-talker protein 1; MPK1-like protein kinase 1", "protein_names_refseq": "putative protein kinase KDX1", "tax_id": 559292, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (sce:YKL161C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11062466;18055054;20489023;24374639;8091859;8196765;9111331", "class_list": "", "function": "Serine/threonine-protein kinase involved in the SLT2 mitogen-activated (MAP) kinase signaling pathway that regulates cell wall integrity. May also be involved in the mating pheromone and the CWI MAPK pathways., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX38", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0007165 signal transduction;GO:0000086 G2/M transition of mitotic cell cycle;GO:0009272 fungal-type cell wall biogenesis;GO:0141124 intracellular signaling cassette", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P36005-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36006-1", "uniprot_id": [ { "id": "MYO3_YEAST", "url": "https://www.uniprot.org/uniprot/P36006", "type": "external" } ], "mass": 142451.0, "length": 1272, "protein_name": "Myosin-3", "gene_name": "MYO3", "organism": "Yeast", "refseq_name": "myosin 3", "refseq_ac": [ { "id": "NP_012793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012793", "type": "external" } ], "gene_names_uniprotkb": "MYO3", "gene_names_refseq": "MYO3", "protein_names_uniprotkb": "Myosin-3; Actin-dependent myosin-I MYO3; Class I unconventional myosin MYO3; Type I myosin MYO3", "protein_names_refseq": "myosin 3", "tax_id": 559292, "disease": "focal segmental glomerulosclerosis 6 (Disease Ontology:DOID:0111131)", "pathway": " (sce:YKL129C)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10648568;10648569;11875433;11901111;12725728;12808026;14562106;16600966;17330950;17522383;18407956;19779198;24374639;27821475;30516470;32597660;33481703;33491328;7728870;8196765;8614799;8682864;9388196", "class_list": "", "function": "One of two redundant type-I myosins implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions redundantly with LAS17 as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Motor domain phosphorylation by PAK kinases CLA4 and STE20 promotes CDC42-regulated actin assembly. Functions together with the NPF PAN1 in late stages of endocytosis. Motor domain phosphorylation by PDK1 kinases PKH1 and PKH2, and by SGK kinases YPK1 and YPK2, promotes ligand-induced, but not constitutive endocytosis of the G protein-coupled receptor STE2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VX66", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0051015 actin filament binding;GO:0017022 myosin binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0051286 cell tip;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0071944 cell periphery", "go_biological_process": "GO:0006897 endocytosis;GO:0006970 response to osmotic stress;GO:0007015 actin filament organization;GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P36006-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36007-1", "uniprot_id": [ { "id": "LTHAD_YEAST", "url": "https://www.uniprot.org/uniprot/P36007", "type": "external" } ], "mass": 34899.0, "length": 326, "protein_name": "L-threo-3-hydroxyaspartate ammonia-lyase", "gene_name": "SRY1", "organism": "Yeast", "refseq_name": "threo-3-hydroxy-L-aspartate ammonia-lyase SRY1", "refseq_ac": [ { "id": "NP_012704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012704", "type": "external" } ], "gene_names_uniprotkb": "SRY1", "gene_names_refseq": "SRY1", "protein_names_uniprotkb": "L-threo-3-hydroxyaspartate ammonia-lyase; 4.3.1.16; L-threo-3-hydroxyaspartate dehydratase", "protein_names_refseq": "threo-3-hydroxy-L-aspartate ammonia-lyase SRY1", "tax_id": 559292, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (sce:YKL218C); (R-SCE-977347)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12951240;18407956;22814378;23749301;24374639;33491328;7941750;8196765", "class_list": "", "function": "Catalyzes the deamination of L-threo-3-hydroxyaspartate to oxaloacetate and ammonia. Shows a high specificity towards L-threo-3-hydroxyaspartate as other 3-hydroxyaminoacids, i.e. D,L-erythro- and D-threo-3-hydroxyaspartate, D-threonine, L-threonine, D,L-allothreonine, D-serine, and L-serine, are not substrates for this enzyme. Exhibits no detectable serine racemase activity. Is responsible for the 3-hydroxyaspartate resistance of S.cerevisiae, and thus may be involved in the detoxification of naturally occurring 3-hydroxyaspartate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWY5", "ec_number_list": [ { "id": "4.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.1.16", "type": "external" } ], "go_molecular_function": "GO:0008721 D-serine ammonia-lyase activity;GO:0030378 serine racemase activity;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0030170 pyridoxal phosphate binding", "go_cellular_component": "", "go_biological_process": "GO:0042219 modified amino acid catabolic process;GO:0006520 amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P36007-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36009-1", "uniprot_id": [ { "id": "DHR2_YEAST", "url": "https://www.uniprot.org/uniprot/P36009", "type": "external" } ], "mass": 82713.0, "length": 735, "protein_name": "Probable ATP-dependent RNA helicase DHR2", "gene_name": "DHR2", "organism": "Yeast", "refseq_name": "RNA helicase", "refseq_ac": [ { "id": "NP_012845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012845", "type": "external" } ], "gene_names_uniprotkb": "DHR2; YKL408", "gene_names_refseq": "DHR2", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DHR2; 3.6.4.13; DEAH box RNA helicase DHR2; Helicase JA2", "protein_names_refseq": "RNA helicase", "tax_id": 559292, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YKL078W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10982841;14562106;21941128;22902402;24374639;26149687;33481703;33491328;8196765;8203165", "class_list": "", "function": "Probable ATP-binding RNA helicase. Required for 18S rRNA synthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXK9;Q07040", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.1.1.260", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.260", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0003725 double-stranded RNA binding;GO:0004386 helicase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0042254 ribosome biogenesis;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P36009-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36012-1", "uniprot_id": [ { "id": "CENPA_YEAST", "url": "https://www.uniprot.org/uniprot/P36012", "type": "external" } ], "mass": 26841.0, "length": 229, "protein_name": "Histone H3-like centromeric protein CSE4", "gene_name": "CSE4", "organism": "Yeast", "refseq_name": "centromeric DNA-binding histone H3-like protein CSE4", "refseq_ac": [ { "id": "NP_012875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012875", "type": "external" } ], "gene_names_uniprotkb": "CSE4; CSL2; YKL262", "gene_names_refseq": "CSE4; CSL2", "protein_names_uniprotkb": "Histone H3-like centromeric protein CSE4; CENP-A homolog; CENPA homolog; Chromosome segregation protein 4", "protein_names_refseq": "centromeric DNA-binding histone H3-like protein CSE4", "tax_id": 559292, "disease": "male infertility (Disease Ontology:DOID:12336); oligospermia (Disease Ontology:DOID:14228); cancer (Disease Ontology:DOID:162); autoimmune disease (Disease Ontology:DOID:417); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YKL049C)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10323865;10454560;10499801;10891506;10958698;11063678;11257125;11606525;14581449;15530401;15590827;16207811;16631569;16715078;16966420;23637466;24374639;29272409;30726152;32004465;32079723;33491328;7698647;8154189;8196765;9584087;9741625", "class_list": "", "function": "Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for functional chromatin architecture at the yeast 2-micron circle partitioning locus and promotes equal plasmid segregation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXN8", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0043565 sequence-specific DNA binding;GO:0019237 centromeric DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005777 peroxisome;GO:0000776 kinetochore;GO:0000779 condensed chromosome, centromeric region;GO:0043505 CENP-A containing nucleosome", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0000278 mitotic cell cycle;GO:0007080 mitotic metaphase chromosome alignment;GO:0000070 mitotic sister chromatid segregation;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P36012-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36013-1", "uniprot_id": [ { "id": "MAOM_YEAST", "url": "https://www.uniprot.org/uniprot/P36013", "type": "external" } ], "mass": 74376.0, "length": 669, "protein_name": "NAD-dependent malic enzyme, mitochondrial", "gene_name": "MAE1", "organism": "Yeast", "refseq_name": "malate dehydrogenase (oxaloacetate-decarboxylating)", "refseq_ac": [ { "id": "NP_012896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012896", "type": "external" } ], "gene_names_uniprotkb": "MAE1", "gene_names_refseq": "MAE1", "protein_names_uniprotkb": "NAD-dependent malic enzyme, mitochondrial; 1.1.1.38; NAD-ME", "protein_names_refseq": "malate dehydrogenase (oxaloacetate-decarboxylating)", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL029C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;14576278;24374639;33491328;8196765;9603875", "class_list": "", "function": "NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXQ5", "ec_number_list": [ { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "4.1.1.112", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.112", "type": "external" }, { "id": "4.1.3.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.17", "type": "external" } ], "go_molecular_function": "GO:0008948 oxaloacetate decarboxylase activity;GO:0046872 metal ion binding;GO:0051287 NAD binding;GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity;GO:0004470 malic enzyme activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006520 amino acid metabolic process;GO:0006108 malate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P36013-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36014-1", "uniprot_id": [ { "id": "GPX1_YEAST", "url": "https://www.uniprot.org/uniprot/P36014", "type": "external" } ], "mass": 19485.0, "length": 167, "protein_name": "Glutathione peroxidase-like peroxiredoxin 1", "gene_name": "GPX1", "organism": "Yeast", "refseq_name": "glutathione peroxidase GPX1", "refseq_ac": [ { "id": "NP_012899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012899", "type": "external" } ], "gene_names_uniprotkb": "GPX1", "gene_names_refseq": "GPX1", "protein_names_uniprotkb": "Glutathione peroxidase-like peroxiredoxin 1; 1.11.1.24; 1.11.1.9; GPx 1; Glutathione peroxidase homolog 1", "protein_names_refseq": "glutathione peroxidase GPX1", "tax_id": 559292, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); spondylometaphyseal dysplasia Sedaghatian type (Disease Ontology:DOID:0112298); pre-eclampsia (Disease Ontology:DOID:10591); nephrotic syndrome (Disease Ontology:DOID:1184); colon cancer (Disease Ontology:DOID:219); acute kidney failure (Disease Ontology:DOID:3021); gastric adenocarcinoma (Disease Ontology:DOID:3717); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YKL026C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10480913;11445588;17322287;20572871;22659048;24374639;8196765", "class_list": "", "function": "Glutathione peroxidase-like protein that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress (PubMed:10480913, PubMed:11445588). Has peroxidase activity using thioredoxin or glutathione as a reducing power (PubMed:20572871, PubMed:22659048). Involved in peroxisome formation (PubMed:22659048)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXQ8", "ec_number_list": [ { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0004602 glutathione peroxidase activity;GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity;GO:0140824 thioredoxin-dependent peroxiredoxin activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005782 peroxisomal matrix;GO:0005829 cytosol", "go_biological_process": "GO:0007031 peroxisome organization;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P36014-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36015-1", "uniprot_id": [ { "id": "YKT6_YEAST", "url": "https://www.uniprot.org/uniprot/P36015", "type": "external" } ], "mass": 22707.0, "length": 200, "protein_name": "Synaptobrevin homolog YKT6", "gene_name": "YKT6", "organism": "Yeast", "refseq_name": "palmitoyltransferase YKT6", "refseq_ac": [ { "id": "NP_012725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012725", "type": "external" } ], "gene_names_uniprotkb": "YKT6", "gene_names_refseq": "YKT6", "protein_names_uniprotkb": "Synaptobrevin homolog YKT6; 2.3.1.-", "protein_names_refseq": "palmitoyltransferase YKT6", "tax_id": 559292, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (sce:YKL196C); (R-SCE-204005); (R-SCE-6807878); (R-SCE-6811438)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "11474112;17322287;17330950;17563356;18407956;19779198;19795423;19823750;20702584;23749301;24374639;33025734;33274589;33481703;33491328;34965436;8196765", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX04", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0005484 SNAP receptor activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:1990674 Golgi cis cisterna membrane;GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005739 mitochondrion;GO:0005768 endosome", "go_biological_process": "GO:0048210 Golgi vesicle fusion to target membrane;GO:0042144 vacuole fusion, non-autophagic;GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006895 Golgi to endosome transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P36015-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36016-1", "uniprot_id": [ { "id": "LHS1_YEAST", "url": "https://www.uniprot.org/uniprot/P36016", "type": "external" } ], "mass": 99572.0, "length": 881, "protein_name": "Heat shock protein 70 homolog LHS1", "gene_name": "LHS1", "organism": "Yeast", "refseq_name": "Hsp70 family chaperone LHS1", "refseq_ac": [ { "id": "NP_012850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012850", "type": "external" } ], "gene_names_uniprotkb": "LHS1; YKL355", "gene_names_refseq": "CER1; LHS1; SSI1", "protein_names_uniprotkb": "Heat shock protein 70 homolog LHS1; 3.6.1.-", "protein_names_refseq": "Hsp70 family chaperone LHS1", "tax_id": 559292, "disease": "immunodeficiency 59 (Disease Ontology:DOID:0111974)", "pathway": " (sce:YKL073W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10847680;14562106;14704430;24374639;8091863;8196765;8654361", "class_list": "", "function": "Chaperone required for protein translocation and folding in the endoplasmic reticulum., [UniProtKB, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6VXL3", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0031204 post-translational protein targeting to membrane, translocation;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P36016-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36017-1", "uniprot_id": [ { "id": "VPS21_YEAST", "url": "https://www.uniprot.org/uniprot/P36017", "type": "external" } ], "mass": 23081.0, "length": 210, "protein_name": "Vacuolar protein sorting-associated protein 21", "gene_name": "VPS21", "organism": "Yeast", "refseq_name": "Rab family GTPase VPS21", "refseq_ac": [ { "id": "NP_014732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014732", "type": "external" } ], "gene_names_uniprotkb": "VPS21; VPS12; VPT12; YOR3154C; YPT21; YPT51", "gene_names_refseq": "VPS12; VPS21; VPT12; YPT21; YPT51", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 21; GTP-binding protein YPT51; Vacuolar protein-targeting protein 12", "protein_names_refseq": "Rab family GTPase VPS21", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557)", "pathway": " (sce:YOR089C); (R-SCE-6798695); (R-SCE-8873719); (R-SCE-8876198); (R-SCE-983231)", "pathway_count": 5, "publication_count": 22, "publication_id_list": "10021387;10329739;10359603;10559187;10679018;10756108;11359917;12589066;14562106;14576278;17563356;18407956;23749301;24374639;32391792;32597660;33481703;33491328;8137814;8163546;9169874;9200815", "class_list": "", "function": "Required for protein transport to the vacuole. Involved in two vesicle trafficking steps to the prevacuolar compartment (PVC), regulating the docking of endosomes and Golgi vesicles to the PVC by interacting with PEP7/VAC1 on the PVC membrane and promoting SNARE complex formation (PubMed:10679018, PubMed:8137814). May be involved in recruiting the MON1-CCZ1 complex to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns[3]P) or other charged lipids, leading to recruitment of YPT7 (PubMed:32391792)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2F0", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0006897 endocytosis;GO:0036010 protein localization to endosome;GO:0006895 Golgi to endosome transport;GO:0061709 reticulophagy", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P36017-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36018-1", "uniprot_id": [ { "id": "YPT52_YEAST", "url": "https://www.uniprot.org/uniprot/P36018", "type": "external" } ], "mass": 26132.0, "length": 234, "protein_name": "GTP-binding protein YPT52", "gene_name": "YPT52", "organism": "Yeast", "refseq_name": "Rab family GTPase YPT52", "refseq_ac": [ { "id": "NP_012939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012939", "type": "external" } ], "gene_names_uniprotkb": "YPT52; YK112", "gene_names_refseq": "YPT52", "protein_names_uniprotkb": "GTP-binding protein YPT52", "protein_names_refseq": "Rab family GTPase YPT52", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557)", "pathway": " (sce:YKR014C); (R-SCE-6798695); (R-SCE-8873719); (R-SCE-8876198)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10713261;11785952;11943201;14562106;18407956;19779198;21389113;22106047;23749301;24374639;24909858;32391792;32597660;33481703;33491328;8163546;8196765", "class_list": "", "function": "Required for transport in the endocytic pathway and for correct sorting of the vacuolar hydrolases suggesting a possible intersection of the endocytic with the vacuolar sorting pathway (PubMed:21389113). May be involved in recruiting the MON1-CCZ1 complex to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns[3]P) or other charged lipids, leading to recruitment of YPT7 (PubMed:32391792)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX79", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0005770 late endosome", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0036010 protein localization to endosome;GO:0006895 Golgi to endosome transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P36018-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36022-1", "uniprot_id": [ { "id": "DYHC_YEAST", "url": "https://www.uniprot.org/uniprot/P36022", "type": "external" } ], "mass": 471348.0, "length": 4092, "protein_name": "Dynein heavy chain, cytoplasmic", "gene_name": "DYN1", "organism": "Yeast", "refseq_name": "dynein heavy chain", "refseq_ac": [ { "id": "NP_012980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012980", "type": "external" } ], "gene_names_uniprotkb": "DYN1; DHC1", "gene_names_refseq": "DHC1; DYN1; PAC6", "protein_names_uniprotkb": "Dynein heavy chain, cytoplasmic; DYHC; Dynein heavy chain, cytosolic", "protein_names_refseq": "dynein heavy chain", "tax_id": 559292, "disease": "lissencephaly (Disease Ontology:DOID:0050453); congenital muscular dystrophy (Disease Ontology:DOID:0050557); complex cortical dysplasia with other brain malformations 13 (Disease Ontology:DOID:0061144); autosomal dominant intellectual developmental disorder 13 (Disease Ontology:DOID:0070043); spinal muscular atrophy with lower extremity predominant 1 (Disease Ontology:DOID:0070351); polymicrogyria (Disease Ontology:DOID:0080918); Charcot-Marie-Tooth disease axonal type 2O (Disease Ontology:DOID:0110175); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); epilepsy (Disease Ontology:DOID:1826); nervous system disease (Disease Ontology:DOID:863)", "pathway": " (sce:YKR054C); (R-SCE-6798695)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "14562095;14562106;15642746;19779198;19795423;19823750;22031224;24374639;33491328;8196765;8234262;8248224", "class_list": "", "function": "Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXB5", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0000235 astral microtubule;GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0005881 cytoplasmic microtubule;GO:0005868 cytoplasmic dynein complex", "go_biological_process": "GO:0000132 establishment of mitotic spindle orientation;GO:0040001 establishment of mitotic spindle localization;GO:0007052 mitotic spindle organization;GO:0000070 mitotic sister chromatid segregation;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P36022-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36033-1", "uniprot_id": [ { "id": "FRE2_YEAST", "url": "https://www.uniprot.org/uniprot/P36033", "type": "external" } ], "mass": 80072.0, "length": 711, "protein_name": "Ferric/cupric reductase transmembrane component 2", "gene_name": "FRE2", "organism": "Yeast", "refseq_name": "ferric/cupric-chelate reductase", "refseq_ac": [ { "id": "NP_012702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012702", "type": "external" } ], "gene_names_uniprotkb": "FRE2", "gene_names_refseq": "FRE2", "protein_names_uniprotkb": "Ferric/cupric reductase transmembrane component 2; 1.16.1.9; Ferric-chelate reductase 2", "protein_names_refseq": "ferric/cupric-chelate reductase", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL220C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10341420;11120744;16024809;16847258;24374639;7720713;8091865;8164662;8196765;9153234;9200812;9726978", "class_list": "", "function": "Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6VWY3", "ec_number_list": [ { "id": "1.16.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.9", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0052851 ferric-chelate reductase (NADPH) activity;GO:0000293 ferric-chelate reductase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0015677 copper ion import;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P36033-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36035-1", "uniprot_id": [ { "id": "JEN1_YEAST", "url": "https://www.uniprot.org/uniprot/P36035", "type": "external" } ], "mass": 69376.0, "length": 616, "protein_name": "Carboxylic acid transporter protein homolog", "gene_name": "JEN1", "organism": "Yeast", "refseq_name": "monocarboxylate/H+ symporter", "refseq_ac": [ { "id": "NP_012705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012705", "type": "external" } ], "gene_names_uniprotkb": "JEN1", "gene_names_refseq": "JEN1", "protein_names_uniprotkb": "Carboxylic acid transporter protein homolog", "protein_names_refseq": "monocarboxylate/H+ symporter", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL217W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12872131;16847258;17761666;19779198;22814378;24374639;33481703;33491328;7941750;8196765", "class_list": "", "function": "Essential to lactate transport., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWY6", "ec_number_list": [], "go_molecular_function": "GO:0015136 sialic acid transmembrane transporter activity;GO:0046943 carboxylic acid transmembrane transporter activity;GO:0097079 selenite:proton symporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0035879 plasma membrane lactate transport;GO:0097080 plasma membrane selenite transport;GO:0006849 plasma membrane pyruvate transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P36035-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36041-1", "uniprot_id": [ { "id": "EAP1_YEAST", "url": "https://www.uniprot.org/uniprot/P36041", "type": "external" } ], "mass": 69762.0, "length": 632, "protein_name": "Protein EAP1", "gene_name": "EAP1", "organism": "Yeast", "refseq_name": "Eap1p", "refseq_ac": [ { "id": "NP_012718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012718", "type": "external" } ], "gene_names_uniprotkb": "EAP1", "gene_names_refseq": "EAP1", "protein_names_uniprotkb": "Protein EAP1; eIF4E-associated protein 1", "protein_names_refseq": "Eap1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL204W)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10848587;11114520;14562095;14562106;15665377;15848184;16120600;17287358;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32027465;32597660;33229814;33481703;33491328;8196765", "class_list": "", "function": "Can regulate translation through binding to eIF4E. Competes with eIF4G and p20 for binding to eIF4E in vivo and inhibits cap-dependent translation in vitro. Plays a role in cell growth and is implicated in the TOR signaling cascade. Functions independently of eIF4E to maintain genetic stability and to attenuate GCN4 translation upon TOR inactivation., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 21, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 21, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 21, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 33, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "D6VWZ9", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0008190 eukaryotic initiation factor 4E binding", "go_cellular_component": "GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0017148 negative regulation of translation;GO:0006402 mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "P36041-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36047-1", "uniprot_id": [ { "id": "SDS22_YEAST", "url": "https://www.uniprot.org/uniprot/P36047", "type": "external" } ], "mass": 38887.0, "length": 338, "protein_name": "Protein phosphatase 1 regulatory subunit SDS22", "gene_name": "SDS22", "organism": "Yeast", "refseq_name": "type 1 protein phosphatase-activating protein SDS22", "refseq_ac": [ { "id": "NP_012728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012728", "type": "external" } ], "gene_names_uniprotkb": "SDS22; EGP1", "gene_names_refseq": "EGP1; SDS22", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit SDS22", "protein_names_refseq": "type 1 protein phosphatase-activating protein SDS22", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL193C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562106;14690591;17322287;18407956;19779198;20489023;24374639;33481703;33491328;7791785;8196765;8394042", "class_list": "", "function": "Regulator of the mitotic function of yeast type 1 protein phosphatase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX07", "ec_number_list": [], "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0019888 protein phosphatase regulator activity;GO:0072542 protein phosphatase activator activity", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0051457 maintenance of protein location in nucleus;GO:0051276 chromosome organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P36047-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36048-1", "uniprot_id": [ { "id": "SN114_YEAST", "url": "https://www.uniprot.org/uniprot/P36048", "type": "external" } ], "mass": 114041.0, "length": 1008, "protein_name": "Pre-mRNA-splicing factor SNU114", "gene_name": "SNU114", "organism": "Yeast", "refseq_name": "U5 snRNP GTPase SNU114", "refseq_ac": [ { "id": "NP_012748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012748", "type": "external" } ], "gene_names_uniprotkb": "SNU114; GIN10; YKL637", "gene_names_refseq": "GIN10; SNU114", "protein_names_uniprotkb": "Pre-mRNA-splicing factor SNU114; 114 kDa U5 small nuclear ribonucleoprotein component; Growth inhibitory protein 10", "protein_names_refseq": "U5 snRNP GTPase SNU114", "tax_id": 559292, "disease": "mandibulofacial dysostosis, Guion-Almeida type (Disease Ontology:DOID:0080196); esophageal atresia (Disease Ontology:DOID:10485); microcephaly (Disease Ontology:DOID:10907); hepatitis B (Disease Ontology:DOID:2043); Treacher Collins syndrome (Disease Ontology:DOID:2908); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YKL173W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10449419;11884590;14562106;14690591;15665377;17330950;18407956;18953335;19779198;19795423;19823750;19854871;21126336;23749301;24374639;24440502;32597660;33481703;33491328;8091858;8196765;9233818", "class_list": "", "function": "Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX27", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0030623 U5 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0071007 U2-type catalytic step 2 spliceosome;GO:0005682 U5 snRNP", "go_biological_process": "GO:0000349 generation of catalytic spliceosome for first transesterification step;GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P36048-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36049-1", "uniprot_id": [ { "id": "EBP2_YEAST", "url": "https://www.uniprot.org/uniprot/P36049", "type": "external" } ], "mass": 49734.0, "length": 427, "protein_name": "rRNA-processing protein EBP2", "gene_name": "EBP2", "organism": "Yeast", "refseq_name": "Ebp2p", "refseq_ac": [ { "id": "NP_012749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012749", "type": "external" } ], "gene_names_uniprotkb": "EBP2; YKL636", "gene_names_refseq": "EBP2", "protein_names_uniprotkb": "rRNA-processing protein EBP2; EBNA1-binding protein homolog", "protein_names_refseq": "Ebp2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL172W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10849420;10947841;17287358;17330950;18407956;18603780;19779198;19795423;19823750;20702584;21126336;21177495;23749301;24374639;30516470;32597660;33481703;33491328;8091858;8196765", "class_list": "", "function": "Required for the processing of the 27S pre-rRNA. Probably involved in the step of the processing of the 27 SA precursor into the 27 SB intermediate., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX28", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0034399 nuclear periphery", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0006364 rRNA processing;GO:0000280 nuclear division", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P36049-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36051-1", "uniprot_id": [ { "id": "MCD4_YEAST", "url": "https://www.uniprot.org/uniprot/P36051", "type": "external" } ], "mass": 105693.0, "length": 919, "protein_name": "GPI ethanolamine phosphate transferase 1", "gene_name": "MCD4", "organism": "Yeast", "refseq_name": "mannose-ethanolamine phosphotransferase MCD4", "refseq_ac": [ { "id": "NP_012756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012756", "type": "external" } ], "gene_names_uniprotkb": "MCD4; FSR2; SSU21; YKL619; ZRG16", "gene_names_refseq": "FSR2; MCD4; SSU21; ZRG16", "protein_names_uniprotkb": "GPI ethanolamine phosphate transferase 1; 2.-.-.-; Morphogenesis checkpoint-dependent protein 4; Supersecretion of u-PA protein 21", "protein_names_refseq": "mannose-ethanolamine phosphotransferase MCD4", "tax_id": 559292, "disease": "multiple congenital anomalies-hypotonia-seizures syndrome 1 (Disease Ontology:DOID:0080138); holoprosencephaly (Disease Ontology:DOID:4621)", "pathway": " (sce:YKL165C); (R-SCE-162710)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10069808;10514566;11470244;12023081;12807869;14562095;16233801;16704983;18407956;24374639;33491328;8091859;8196765", "class_list": "", "function": "Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. Ethanolamine phosphate on the alpha-1,4-linked mannose is essential for further mannosylation by GPI10 and is necessary for an efficient recognition of GPI lipids and GPI proteins by the GPI transamidase, for the efficient transport of GPI anchored proteins from endoplasmic reticulum to Golgi and for the physiological incorporation of ceramides into GPI anchors by lipid remodeling. Also involved in non-mitochondrial ATP movements across membrane and participates in Golgi and endoplasmic reticulum function, Also required for the incorporation of BGL2 into the cell wall., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6VX34", "ec_number_list": [ { "id": "2.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0051377 mannose-ethanolamine phosphotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005774 vacuolar membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0015867 ATP transport;GO:0006506 GPI anchor biosynthetic process;GO:0071555 cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P36051-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36057-1", "uniprot_id": [ { "id": "SRPB_YEAST", "url": "https://www.uniprot.org/uniprot/P36057", "type": "external" } ], "mass": 26974.0, "length": 244, "protein_name": "Signal recognition particle receptor subunit beta", "gene_name": "SRP102", "organism": "Yeast", "refseq_name": "Signal recognition particle receptor subunit beta", "refseq_ac": [ { "id": "NP_012768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012768", "type": "external" } ], "gene_names_uniprotkb": "SRP102; YKL609", "gene_names_refseq": "SRP102", "protein_names_uniprotkb": "Signal recognition particle receptor subunit beta; SR-beta", "protein_names_refseq": "Signal recognition particle receptor subunit beta", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL154W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12654246;14562106;24374639;8091859;8196765", "class_list": "", "function": "Component of the signal recognition particle (SRP) complex receptor (SR) (By similarity). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). May mediate the membrane association of SR (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX44", "ec_number_list": [], "go_molecular_function": "GO:0005047 signal recognition particle binding;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005785 signal recognition particle receptor complex;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045047 protein targeting to ER;GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P36057-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36060-1", "uniprot_id": [ { "id": "MCR1_YEAST", "url": "https://www.uniprot.org/uniprot/P36060", "type": "external" } ], "mass": 34138.0, "length": 302, "protein_name": "NADH-cytochrome b5 reductase 2", "gene_name": "MCR1", "organism": "Yeast", "refseq_name": "cytochrome-b5 reductase", "refseq_ac": [ { "id": "NP_012772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012772", "type": "external" } ], "gene_names_uniprotkb": "MCR1; YKL605", "gene_names_refseq": "MCR1", "protein_names_uniprotkb": "NADH-cytochrome b5 reductase 2; 1.6.2.2; Mitochondrial cytochrome b reductase; p34/p32", "protein_names_refseq": "cytochrome-b5 reductase", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL150W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11420140;14562095;14562106;15590813;16407407;16689936;17244705;17330950;22984289;24374639;27694803;33481703;33491328;8001120;8091859;8196765;9199337;9866716", "class_list": "", "function": "The outer membrane form may mediate the reduction of outer membrane cytochrome b5 (PubMed:8001120). The soluble inter-membrane space form may transfer electrons from external NADH to cytochrome c, thereby mediating an antimycin-insensitive, energy-coupled oxidation of external NADH by yeast mitochondria (PubMed:8001120). Involved in the reduction of D-erythroascorbyl free radicals (PubMed:11420140). May play a minor role in complementing the function of CBR1 as a DPH3 reductase in the first step of diphthamide biosynthesis and tRNA Wobble base mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine) formation (PubMed:27694803)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2TBM9;D6VX47", "ec_number_list": [ { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0090524 cytochrome-b5 reductase activity, acting on NADH", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0006696 ergosterol biosynthetic process;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P36060-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36068-1", "uniprot_id": [ { "id": "SHE2_YEAST", "url": "https://www.uniprot.org/uniprot/P36068", "type": "external" } ], "mass": 28251.0, "length": 246, "protein_name": "SWI5-dependent HO expression protein 2", "gene_name": "SHE2", "organism": "Yeast", "refseq_name": "She2p", "refseq_ac": [ { "id": "NP_012792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012792", "type": "external" } ], "gene_names_uniprotkb": "SHE2", "gene_names_refseq": "SHE2", "protein_names_uniprotkb": "SWI5-dependent HO expression protein 2", "protein_names_refseq": "She2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL130C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10212145;10359695;10792032;11032818;11101531;12499354;13679573;14561888;14562106;14691136;15328357;15537539;15899876;16890529;17322287;17563356;18566598;19244342;19710186;20713510;24374639;36921931;8196765;9809065", "class_list": "", "function": "RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Recruits the MYO4-SHE3 complex to the ASH1 mRNA. Also recruits LOC1 and PUF6 to ASH1 mRNA, which are required for translational repression of this mRNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX65", "ec_number_list": [], "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003729 mRNA binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005934 cellular bud tip", "go_biological_process": "GO:0008298 intracellular mRNA localization;GO:0051028 mRNA transport;GO:0007533 mating type switching", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P36068-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36075-1", "uniprot_id": [ { "id": "CUE2_YEAST", "url": "https://www.uniprot.org/uniprot/P36075", "type": "external" } ], "mass": 50874.0, "length": 443, "protein_name": "Endonuclease CUE2", "gene_name": "CUE2", "organism": "Yeast", "refseq_name": "Cue2p", "refseq_ac": [ { "id": "NP_012833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012833", "type": "external" } ], "gene_names_uniprotkb": "CUE2", "gene_names_refseq": "CUE2", "protein_names_uniprotkb": "Endonuclease CUE2; Coupling of ubiquitin conjugation to ER degradation protein 2", "protein_names_refseq": "Cue2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL090W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12787503;15665377;17563356;18407956;23749301;24374639;31219035;32597660;33481703;33491328;36583309;8196765", "class_list": "", "function": "mRNA endonuclease involved in the No-Go Decay (NGD) pathway, which catalyzes mRNA cleavage and degradation in response to ribosome collisions (PubMed:31219035, PubMed:36583309). Acts downstream of the ribosome collision sensor HEL2 (PubMed:36583309). Specifically recognizes and binds RPS7/eS7 polyubiquitinated by MOT2/NOT4 and HEL2, promoting CUE2 recruitment to stalled ribosomes, where it mediates mRNA cleavage upstream of the colliding ribosome (PubMed:36583309). Also mediates mRNA cleavage within colliding ribosomes: recruited to colliding ribosomes downstream of the RQT (ribosome quality control trigger) complex following disassembly of stalled ribosomes and cleaves mRNAs partially released from the colliding ribosome (PubMed:36583309)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXJ8", "ec_number_list": [], "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding;GO:0004519 endonuclease activity;GO:0004521 RNA endonuclease activity;GO:0043130 ubiquitin binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P36075-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36080-1", "uniprot_id": [ { "id": "RRP14_YEAST", "url": "https://www.uniprot.org/uniprot/P36080", "type": "external" } ], "mass": 50482.0, "length": 434, "protein_name": "Ribosomal RNA-processing protein 14", "gene_name": "RRP14", "organism": "Yeast", "refseq_name": "ribosome biosynthesis protein RRP14", "refseq_ac": [ { "id": "NP_012841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012841", "type": "external" } ], "gene_names_uniprotkb": "RRP14", "gene_names_refseq": "RRP14", "protein_names_uniprotkb": "Ribosomal RNA-processing protein 14; Ribosome biogenesis protein RRP14", "protein_names_refseq": "ribosome biosynthesis protein RRP14", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL082C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "16544271;17272295;17804645;18407956;19684113;19795423;19823750;22814378;24374639;30516470;33481703;33491328;8196765", "class_list": "", "function": "Involved in ribosome biogenesis and cell polarity. Required for the synthesis of both 40S and 60S ribosomal subunits and may also play some direct role in correct positioning of the mitotic spindle during mitosis., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXK5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P36080-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36081-1", "uniprot_id": [ { "id": "PSG1_YEAST", "url": "https://www.uniprot.org/uniprot/P36081", "type": "external" } ], "mass": 46036.0, "length": 392, "protein_name": "PMA1 stabilization in the Golgi protein 1", "gene_name": "PSG1", "organism": "Yeast", "refseq_name": "Psg1p", "refseq_ac": [ { "id": "NP_012846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012846", "type": "external" } ], "gene_names_uniprotkb": "PSG1", "gene_names_refseq": "PSG1", "protein_names_uniprotkb": "PMA1 stabilization in the Golgi protein 1", "protein_names_refseq": "Psg1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL077W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;17210951;24374639;26764011;28727280;8196765", "class_list": "", "function": "PSG1 is cleaved by KEX2 in two stable peptides, PSG1-N' and PSG1-C', the former supporting a role in maturation quality control, the latter having a role in modulating vesicular trafficking., [UniProtKB, PubMed]; With EXP1, the specific cargo receptor protein for the plasma membrane ATPase PMA1, is involved in the transport and/or maturation of PMA1 (PubMed:28727280). EXP1 and PSG1 probably act sequentially to promote PMA1 sorting between the ER and the Golgi, with EXP1 promoting PMA1 export from the ER to the Golgi while PSG1 has a role in PMA1 maturation or quality control in the Golgi (PubMed:28727280). PSG1 might also couple PMA1 sorting and maturation in the early secretory pathway with the glycosylation machinery (Probable)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 31, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 31, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 31, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 31, "binding_glycan_count": 0, "secondary_ac_list": "D6VXL0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen;GO:0030663 COPI-coated vesicle membrane", "go_biological_process": "GO:0006605 protein targeting;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P36081-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36084-1", "uniprot_id": [ { "id": "MUD2_YEAST", "url": "https://www.uniprot.org/uniprot/P36084", "type": "external" } ], "mass": 60460.0, "length": 527, "protein_name": "Splicing factor MUD2", "gene_name": "MUD2", "organism": "Yeast", "refseq_name": "Mud2p", "refseq_ac": [ { "id": "NP_012849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012849", "type": "external" } ], "gene_names_uniprotkb": "MUD2; YKL358", "gene_names_refseq": "MUD2", "protein_names_uniprotkb": "Splicing factor MUD2", "protein_names_refseq": "Mud2p", "tax_id": 559292, "disease": "developmental delay, dysmorphic facies, and brain anomalies (Disease Ontology:DOID:0060933)", "pathway": " (sce:YKL074C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10376880;14562106;17287358;19795423;19823750;24374639;33491328;7926772;8091863;8196765;9150140", "class_list": "", "function": "Splicing factor that contacts pre-mRNA directly and is a component of the pre-mRNA-U1 snRNP complex (commitment complex 2) that forms during early spliceosome assembly in yeast extracts., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXL2", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0030628 pre-mRNA 3'-splice site binding;GO:0045131 pre-mRNA branch point binding;GO:0008187 poly-pyrimidine tract binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0000243 commitment complex;GO:0071004 U2-type prespliceosome;GO:0089701 U2AF complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:0000348 mRNA branch site recognition", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P36084-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36088-1", "uniprot_id": [ { "id": "FRMSR_YEAST", "url": "https://www.uniprot.org/uniprot/P36088", "type": "external" } ], "mass": 19734.0, "length": 180, "protein_name": "Free methionine-R-sulfoxide reductase", "gene_name": "YKL340", "organism": "Yeast", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "YKL340", "gene_names_refseq": "", "protein_names_uniprotkb": "Free methionine-R-sulfoxide reductase; 1.8.4.14; GAF domain-containing protein YKL069W; fRMsr", "protein_names_refseq": "", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL069W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11032796;14562095;14562106;19049972;24374639;33481703;8091863;8196765", "class_list": "", "function": "Catalyzes the reversible oxidation-reduction of the R-enantiomer of free methionine sulfoxide to methionine. Does not act on S-enantiomer of free methionine sulfoxide or R-enantiomer of dabsylated methionine sulfoxide. Involved in protection against oxidative stress., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXL7", "ec_number_list": [ { "id": "1.8.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.14", "type": "external" } ], "go_molecular_function": "GO:0033745 L-methionine-(R)-S-oxide reductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P36088-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36094-1", "uniprot_id": [ { "id": "SPC42_YEAST", "url": "https://www.uniprot.org/uniprot/P36094", "type": "external" } ], "mass": 42271.0, "length": 363, "protein_name": "Spindle pole body component SPC42", "gene_name": "SPC42", "organism": "Yeast", "refseq_name": "Spc42p", "refseq_ac": [ { "id": "NP_012882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012882", "type": "external" } ], "gene_names_uniprotkb": "SPC42; YKL255", "gene_names_refseq": "SPC42", "protein_names_uniprotkb": "Spindle pole body component SPC42", "protein_names_refseq": "Spc42p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL042W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10339566;15296722;17330950;17563356;18407956;18850724;19779198;19795423;19823750;20489023;22218487;23749301;24374639;30516470;32597660;33481703;33491328;8154189;8196765;8603920", "class_list": "", "function": "Forms a polymeric layer at the periphery of the spindle pole body (SPB) central plaque which has an essential function during SPB duplication and may facilitate attachment of the SPB to the nuclear membrane., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXP4", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005634 nucleus;GO:0005821 intermediate layer of spindle pole body;GO:0005823 central plaque of spindle pole body", "go_biological_process": "GO:0010968 regulation of microtubule nucleation;GO:0030474 spindle pole body duplication", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P36094-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36095-1", "uniprot_id": [ { "id": "VPS24_YEAST", "url": "https://www.uniprot.org/uniprot/P36095", "type": "external" } ], "mass": 26242.0, "length": 224, "protein_name": "Vacuolar protein-sorting-associated protein 24", "gene_name": "VPS24", "organism": "Yeast", "refseq_name": "ESCRT-III subunit protein VPS24", "refseq_ac": [ { "id": "NP_012883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012883", "type": "external" } ], "gene_names_uniprotkb": "VPS24; DID3; YKL254", "gene_names_refseq": "DID3; VPL26; VPS24", "protein_names_uniprotkb": "Vacuolar protein-sorting-associated protein 24; DOA4-independent degradation protein 3; ESCRT-III complex subunit VPS24", "protein_names_refseq": "ESCRT-III subunit protein VPS24", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL041W); (R-SCE-1632852); (R-SCE-917729); (R-SCE-9668328)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "11559748;12194857;14562095;14562106;17130288;17322287;18854142;21126336;22106047;24374639;32597660;33491328;8154189;8196765;9606181", "class_list": "", "function": "Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole. Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment oflate-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. The DID4/VPS2-VPS24 subcomplex is required for the VPS4-dependent dissociation of ESCRT-III., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXP5", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005771 multivesicular body", "go_biological_process": "GO:0015031 protein transport;GO:0070676 intralumenal vesicle formation;GO:0045324 late endosome to vacuole transport;GO:0032509 endosome transport via multivesicular body sorting pathway;GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P36095-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36096-1", "uniprot_id": [ { "id": "TUL1_YEAST", "url": "https://www.uniprot.org/uniprot/P36096", "type": "external" } ], "mass": 87880.0, "length": 758, "protein_name": "Transmembrane E3 ubiquitin-protein ligase 1", "gene_name": "TUL1", "organism": "Yeast", "refseq_name": "ubiquitin-protein ligase TUL1", "refseq_ac": [ { "id": "NP_012890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012890", "type": "external" } ], "gene_names_uniprotkb": "TUL1; YKL247", "gene_names_refseq": "TUL1", "protein_names_uniprotkb": "Transmembrane E3 ubiquitin-protein ligase 1; 2.3.2.27; RING-type E3 ubiquitin transferase TUL1", "protein_names_refseq": "ubiquitin-protein ligase TUL1", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL034W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11788821;1481573;15973437;16847258;24374639;25078903;29355480;8196765;8203146", "class_list": "", "function": "Catalytic component of the DSC E3 ubiquitin ligase complexes that tag proteins present in Golgi, endosome and vacuole membranes and function in protein homeostasis under non-stress conditions and support a role in protein quality control (PubMed:25078903, PubMed:29355480). Mediates ubiquitination of vacuolar proteins such as CPS1, PPN1, PEP12 and other proteins containing exposed hydrophilic residues within their transmembrane domains, leading to their sorting into internal vesicles in late endosomes (PubMed:11788821). Targets also the unpalmitoylated endosomal SNARE TLG1 to the MVB pathway (PubMed:15973437)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXQ1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0012505 endomembrane system;GO:0000324 fungal-type vacuole;GO:0044695 Dsc E3 ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0140624 EGAD pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P36096-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36100-1", "uniprot_id": [ { "id": "T2EA_YEAST", "url": "https://www.uniprot.org/uniprot/P36100", "type": "external" } ], "mass": 54742.0, "length": 482, "protein_name": "Transcription initiation factor IIE subunit alpha", "gene_name": "TFA1", "organism": "Yeast", "refseq_name": "transcription factor TFIIE subunit TFA1", "refseq_ac": [ { "id": "NP_012897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012897", "type": "external" } ], "gene_names_uniprotkb": "TFA1", "gene_names_refseq": "TFA1", "protein_names_uniprotkb": "Transcription initiation factor IIE subunit alpha; Factor A 66 kDa subunit; TFIIE-alpha; Transcription factor A large subunit", "protein_names_refseq": "transcription factor TFIIE subunit TFA1", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL028W); (R-SCE-674695); (R-SCE-6807505); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "14562106;24374639;30516470;33481703;33491328;7961670;8196765", "class_list": "", "function": "Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXQ6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005673 transcription factor TFIIE complex;GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0001113 transcription open complex formation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P36100-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36104-1", "uniprot_id": [ { "id": "SWD2_YEAST", "url": "https://www.uniprot.org/uniprot/P36104", "type": "external" } ], "mass": 37122.0, "length": 329, "protein_name": "COMPASS component SWD2", "gene_name": "SWD2", "organism": "Yeast", "refseq_name": "WD-repeat containing protein SWD2", "refseq_ac": [ { "id": "NP_012907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012907", "type": "external" } ], "gene_names_uniprotkb": "SWD2; CPS35; SAF37", "gene_names_refseq": "CPS35; SAF37; SWD2", "protein_names_uniprotkb": "COMPASS component SWD2; Complex proteins associated with SET1 protein SWD2; Set1C component SWD2", "protein_names_refseq": "WD-repeat containing protein SWD2", "tax_id": 559292, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (sce:YKL018W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11687631;11742990;11805083;12819204;14562106;15024081;17322287;21126336;24374639;29071121;33491328;8154185;8196765", "class_list": "", "function": "Involved in mediating RNA polymerase II termination. Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation., [UniProtKB]; The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXR8", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0048188 Set1C/COMPASS complex;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0000723 telomere maintenance;GO:0031124 mRNA 3'-end processing;GO:0031126 sno(s)RNA 3'-end processing;GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P36104-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36105-1", "uniprot_id": [ { "id": "RL14A_YEAST", "url": "https://www.uniprot.org/uniprot/P36105", "type": "external" } ], "mass": 15167.0, "length": 138, "protein_name": "Large ribosomal subunit protein eL14A", "gene_name": "RPL14A", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL14 RPL14A", "refseq_ac": [ { "id": "NP_012920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012920", "type": "external" } ], "gene_names_uniprotkb": "RPL14A; YKL153", "gene_names_refseq": "RPL14A", "protein_names_uniprotkb": "Large ribosomal subunit protein eL14A; 60S ribosomal protein L14-A", "protein_names_refseq": "60S ribosomal protein eL14 RPL14A", "tax_id": 559292, "disease": "congenital heart disease (Disease Ontology:DOID:1682); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (sce:YKL006W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10601260;14562095;14562106;19795423;19823750;21109664;22096102;24374639;24524803;32597660;8196765;8488728;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXT1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0016236 macroautophagy;GO:0042273 ribosomal large subunit biogenesis;GO:0002181 cytoplasmic translation;GO:0000027 ribosomal large subunit assembly;GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P36105-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36107-1", "uniprot_id": [ { "id": "AUR1_YEAST", "url": "https://www.uniprot.org/uniprot/P36107", "type": "external" } ], "mass": 45193.0, "length": 401, "protein_name": "Inositol phosphorylceramide synthase catalytic subunit AUR1", "gene_name": "AUR1", "organism": "Yeast", "refseq_name": "inositol phosphorylceramide synthase", "refseq_ac": [ { "id": "NP_012922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012922", "type": "external" } ], "gene_names_uniprotkb": "AUR1", "gene_names_refseq": "AUR1", "protein_names_uniprotkb": "Inositol phosphorylceramide synthase catalytic subunit AUR1; 2.7.1.227; Aureobasidin A resistance protein; IPC synthase catalytic subunit AUR1; Phosphatidylinositol:ceramide phosphoinositol transferase", "protein_names_refseq": "inositol phosphorylceramide synthase", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL004W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10888667;14562106;16847258;17330950;18407956;19047657;19684113;19726565;19779198;20702584;23749301;24374639;32597660;33481703;33491328;8196765;8593016;8668135;9092515", "class_list": "", "function": "Catalytic component of the inositol phosphorylceramide synthase which catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VXT3;Q92324", "ec_number_list": [ { "id": "2.7.1.227", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.227", "type": "external" } ], "go_molecular_function": "GO:0045140 inositol phosphoceramide synthase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane;GO:0070916 inositol phosphoceramide synthase complex", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0006676 mannosyl diphosphorylinositol ceramide metabolic process;GO:0006673 inositol phosphoceramide metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P36107-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36108-1", "uniprot_id": [ { "id": "DID4_YEAST", "url": "https://www.uniprot.org/uniprot/P36108", "type": "external" } ], "mass": 26291.0, "length": 232, "protein_name": "DOA4-independent degradation protein 4", "gene_name": "DID4", "organism": "Yeast", "refseq_name": "ESCRT-III subunit protein DID4", "refseq_ac": [ { "id": "NP_012924", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012924", "type": "external" } ], "gene_names_uniprotkb": "DID4; CHM2; GRD7; REN1; VPL2; VPS2; VPT14", "gene_names_refseq": "CHM2; DID4; GRD7; REN1; VPL2; VPS14; VPS2; VPT14", "protein_names_uniprotkb": "DOA4-independent degradation protein 4; ESCRT-III complex subunit VPS2; Vacuolar protein-sorting-associated protein 2; Vacuolar protein-targeting protein 14", "protein_names_refseq": "ESCRT-III subunit protein DID4", "tax_id": 559292, "disease": "frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (Disease Ontology:DOID:0111227)", "pathway": " (sce:YKL002W); (R-SCE-1632852); (R-SCE-917729); (R-SCE-9668328)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10734188;11559748;12194857;17928861;17949747;18194652;18407956;18854142;22814378;24374639;33481703;33491328;8196765", "class_list": "", "function": "Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment of late-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. Can directly stimulate VPS4 ATPase activity. The DID4/VPS2-VPS24 subcomplex is required for the VPS4-dependent dissociation of ESCRT-III., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXT5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005737 cytoplasm;GO:0005771 multivesicular body", "go_biological_process": "GO:0045053 protein retention in Golgi apparatus;GO:0015031 protein transport;GO:0070676 intralumenal vesicle formation;GO:0045324 late endosome to vacuole transport;GO:0032509 endosome transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P36108-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36112-1", "uniprot_id": [ { "id": "MIC60_YEAST", "url": "https://www.uniprot.org/uniprot/P36112", "type": "external" } ], "mass": 61082.0, "length": 540, "protein_name": "MICOS complex subunit MIC60", "gene_name": "MIC60", "organism": "Yeast", "refseq_name": "Mic60p", "refseq_ac": [ { "id": "NP_012941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012941", "type": "external" } ], "gene_names_uniprotkb": "MIC60; AIM28; FCJ1; FMP13", "gene_names_refseq": "AIM28; FCJ1; FMP13; MIC60", "protein_names_uniprotkb": "MICOS complex subunit MIC60; Altered inheritance of mitochondria protein 28; Formation of crista junctions protein 1; Found in mitochondrial proteome protein 13; Mitofilin", "protein_names_refseq": "Mic60p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR016W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562095;14562106;19300474;19528297;21944719;21987634;22009199;24374639;24687277;8196765", "class_list": "", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX81", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0044284 mitochondrial crista junction;GO:0061617 MICOS complex;GO:0030061 mitochondrial crista", "go_biological_process": "GO:0045041 protein import into mitochondrial intermembrane space;GO:0097753 membrane bending;GO:0042407 cristae formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P36112-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36113-1", "uniprot_id": [ { "id": "HEL1_YEAST", "url": "https://www.uniprot.org/uniprot/P36113", "type": "external" } ], "mass": 63569.0, "length": 551, "protein_name": "E3 ubiquitin-protein ligase HEL1", "gene_name": "HEL1", "organism": "Yeast", "refseq_name": "E3 ubiquitin-protein ligase HEL1", "refseq_ac": [ { "id": "NP_012942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012942", "type": "external" } ], "gene_names_uniprotkb": "HEL1", "gene_names_refseq": "HEL1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HEL1; 2.3.2.31; Histone E3 ligase 1; RING-type E3 ubiquitin transferase HEL1", "protein_names_refseq": "E3 ubiquitin-protein ligase HEL1", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR017C); (R-SCE-5205685); (R-SCE-9646399); (R-SCE-983168)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "14562106;22570702;24374639;33491328;8196765", "class_list": "", "function": "Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX82", "ec_number_list": [ { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "1.14.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036205 histone catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P36113-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36115-1", "uniprot_id": [ { "id": "IRS4_YEAST", "url": "https://www.uniprot.org/uniprot/P36115", "type": "external" } ], "mass": 68880.0, "length": 615, "protein_name": "Increased rDNA silencing protein 4", "gene_name": "IRS4", "organism": "Yeast", "refseq_name": "Irs4p", "refseq_ac": [ { "id": "NP_012944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012944", "type": "external" } ], "gene_names_uniprotkb": "IRS4", "gene_names_refseq": "IRS4", "protein_names_uniprotkb": "Increased rDNA silencing protein 4", "protein_names_refseq": "Irs4p", "tax_id": 559292, "disease": "neurodegeneration with brain iron accumulation (Disease Ontology:DOID:0110734); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (sce:YKR019C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10082585;15265867;15665377;18407956;19779198;21126336;21177495;23749301;24374639;30516470;32597660;33481703;33491328;8196765;9822599", "class_list": "", "function": "With TAX4, acts as a positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover. Negatively regulates signaling through the cell integrity pathway, including the MAP kinase SLT2. Also seems to be involved in rDNA silencing., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX84", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006897 endocytosis;GO:0006914 autophagy;GO:0016197 endosomal transport;GO:0000183 rDNA heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P36115-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36116-1", "uniprot_id": [ { "id": "VPS51_YEAST", "url": "https://www.uniprot.org/uniprot/P36116", "type": "external" } ], "mass": 18912.0, "length": 164, "protein_name": "Vacuolar protein sorting-associated protein 51", "gene_name": "VPS51", "organism": "Yeast", "refseq_name": "Vps51p", "refseq_ac": [ { "id": "NP_012945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012945", "type": "external" } ], "gene_names_uniprotkb": "VPS51; API3; VPS67; WHI6", "gene_names_refseq": "API3; VPS51; VPS67; WHI6", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 51; Apical bud growth protein 3", "protein_names_refseq": "Vps51p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR020W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11957109;12134085;12377769;12446664;12686613;14562106;17322287;21126336;22218487;22814378;24374639;33481703;33491328;8196765", "class_list": "", "function": "Involved in retrograde transport from early and late endosomes to late Golgi. Links the Golgi-associated retrograde protein (GARP) complex to the t-SNARE TLG1, leading to the fusion between the endosomal vesicles with the late Golgi. May also be indirectly involved in apical bud growth., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX85", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000938 GARP complex;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0010008 endosome membrane", "go_biological_process": "GO:0016239 positive regulation of macroautophagy;GO:0016050 vesicle organization;GO:0042147 retrograde transport, endosome to Golgi;GO:0090156 intracellular sphingolipid homeostasis;GO:0008361 regulation of cell size", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P36116-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36117-1", "uniprot_id": [ { "id": "ALY1_YEAST", "url": "https://www.uniprot.org/uniprot/P36117", "type": "external" } ], "mass": 102540.0, "length": 915, "protein_name": "Arrestin-related trafficking adapter 6", "gene_name": "ALY1", "organism": "Yeast", "refseq_name": "Aly1p", "refseq_ac": [ { "id": "NP_012946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012946", "type": "external" } ], "gene_names_uniprotkb": "ALY1; ART6", "gene_names_refseq": "ALY1; ART6", "protein_names_uniprotkb": "Arrestin-related trafficking adapter 6; Arrestin-like protein 1", "protein_names_refseq": "Aly1p", "tax_id": 559292, "disease": "stomach cancer (Disease Ontology:DOID:10534); Reye syndrome (Disease Ontology:DOID:14525); glaucoma (Disease Ontology:DOID:1686); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YKR021W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "14562095;14562106;17330950;17551511;18407956;18976803;19684113;19779198;20489023;21177495;23749301;24374639;24440502;30610170;32597660;33481703;33491328;34965436;8196765", "class_list": "", "function": "May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VX86", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005770 late endosome", "go_biological_process": "GO:2000397 positive regulation of ubiquitin-dependent endocytosis;GO:0006897 endocytosis;GO:0051453 regulation of intracellular pH;GO:0070086 ubiquitin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P36117-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36119-1", "uniprot_id": [ { "id": "RQT4_YEAST", "url": "https://www.uniprot.org/uniprot/P36119", "type": "external" } ], "mass": 60799.0, "length": 530, "protein_name": "RQC trigger complex subunit RQT4", "gene_name": "RQT4", "organism": "Yeast", "refseq_name": "Rqt4p", "refseq_ac": [ { "id": "NP_012948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012948", "type": "external" } ], "gene_names_uniprotkb": "RQT4", "gene_names_refseq": "RQT4", "protein_names_uniprotkb": "RQC trigger complex subunit RQT4", "protein_names_refseq": "Rqt4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR023W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "14562106;17330950;18407956;19684113;19779198;19795423;19823750;21177495;22106047;23749301;24374639;24909858;28223409;28757607;30516470;32203490;32597660;33229814;33481703;33491328;36627279;8196765", "class_list": "", "function": "Component of the RQC trigger (RQT) complex, a multiprotein complex involved in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation (PubMed:28223409, PubMed:28757607, PubMed:32203490, PubMed:36627279). Specifically recognizes and binds RPS20/uS10 ubiquitinated by HEL2, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes (PubMed:32203490, PubMed:36627279)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VX88", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0022626 cytosolic ribosome;GO:0180022 RQC-trigger complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0045893 positive regulation of DNA-templated transcription;GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P36119-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36126-1", "uniprot_id": [ { "id": "SPO14_YEAST", "url": "https://www.uniprot.org/uniprot/P36126", "type": "external" } ], "mass": 195204.0, "length": 1683, "protein_name": "Phospholipase D1", "gene_name": "SPO14", "organism": "Yeast", "refseq_name": "phospholipase D", "refseq_ac": [ { "id": "NP_012956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012956", "type": "external" } ], "gene_names_uniprotkb": "SPO14; PLD1", "gene_names_refseq": "PLD1; SPO14", "protein_names_uniprotkb": "Phospholipase D1; 3.1.4.4; Choline phosphatase 1; Meiosis-specific sporulation-specific protein 14; PLD 1; Phosphatidylcholine-hydrolyzing phospholipase D1", "protein_names_refseq": "phospholipase D", "tax_id": 559292, "disease": "developmental cardiac valvular defect (Disease Ontology:DOID:0080633); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); renal cell carcinoma (Disease Ontology:DOID:4450); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (sce:YKR031C); (R-SCE-1483166); (R-SCE-2029485); (R-SCE-6798695); (R-SCE-8980692)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "14562106;15665377;1582554;17330950;18407956;19779198;20702584;21347278;21954159;22814378;23749301;24374639;32597660;33481703;33491328;34965436;8196765;8576189;8618862", "class_list": "", "function": "Required for meiosis and spore formation. Seems to be involved in the coordinate induction of late meiotic events. PLD activity is induced under sporulation conditions and seems to be necessary to complete the meiotic cycle, but not for vegetative cell growth., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 28, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VX96", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.64", "type": "external" } ], "go_molecular_function": "GO:0004630 phospholipase D activity;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005768 endosome;GO:0005628 prospore membrane", "go_biological_process": "GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction;GO:0009395 phospholipid catabolic process;GO:0006644 phospholipid metabolic process;GO:0000753 cell morphogenesis involved in conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P36126-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36130-1", "uniprot_id": [ { "id": "CAF4_YEAST", "url": "https://www.uniprot.org/uniprot/P36130", "type": "external" } ], "mass": 72832.0, "length": 643, "protein_name": "CCR4-associated factor 4", "gene_name": "CAF4", "organism": "Yeast", "refseq_name": "Caf4p", "refseq_ac": [ { "id": "NP_012962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012962", "type": "external" } ], "gene_names_uniprotkb": "CAF4", "gene_names_refseq": "CAF4", "protein_names_uniprotkb": "CCR4-associated factor 4", "protein_names_refseq": "Caf4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR036C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11113136;12748633;14562095;14562106;14576278;16009724;16835275;17998537;19779198;23749301;24374639;32597660;33481703;33491328;8196765", "class_list": "", "function": "Involved in mitochondrial fission. Has a partially redundant function to MDV1 in acting as an adapter protein, binding to FIS1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase DNM1 to form mitochondrial fission complexes. Plays a key role in determining the polarized localization of those DNM1 clusters that are not immediately involved in the mitochondrial fission process., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX99", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0030014 CCR4-NOT complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0016559 peroxisome fission;GO:0000266 mitochondrial fission", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P36130-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36131-1", "uniprot_id": [ { "id": "SPC34_YEAST", "url": "https://www.uniprot.org/uniprot/P36131", "type": "external" } ], "mass": 34078.0, "length": 295, "protein_name": "DASH complex subunit SPC34", "gene_name": "SPC34", "organism": "Yeast", "refseq_name": "Spc34p", "refseq_ac": [ { "id": "NP_012963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012963", "type": "external" } ], "gene_names_uniprotkb": "SPC34", "gene_names_refseq": "SPC34", "protein_names_uniprotkb": "DASH complex subunit SPC34; 34 kDa spindle pole component protein; Outer kinetochore protein SPC34", "protein_names_refseq": "Spc34p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR037C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "11782438;11799062;12408861;14562095;15640796;15664196;15846338;16415853;16715078;16777964;17330950;17460120;17620411;17643123;18079178;24374639;24930965;25236177;33491328;36701236;8196765", "class_list": "", "function": "Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerization to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase (PubMed:15664196, PubMed:16415853, PubMed:16777964, PubMed:17460120, PubMed:17643123). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules (PubMed:11782438). Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle (PubMed:11782438, PubMed:12408861). During spindle-kinetochore attachment, kinetochores first attach to the lateral surface of spindle microtubules, which supports the congression of chromosomes toward the middle of the dividing cell; they then slide along towards the spindle pole, a process independent of the DASH complex but requiring the NDC80 complex (PubMed:15846338, PubMed:17620411). When the end of a disassembling microtubule reaches the laterally attached kinetochore, the DASH complex together with the NDC80 complex and STU2 convert lateral attachment to end-on capture to produce a structure that can track with microtubule shortening and sustain attachment when tension is applied across sister kinetochores upon their biorientation (PubMed:11782438, PubMed:15640796, PubMed:15664196, PubMed:15846338, PubMed:17620411, PubMed:25236177). Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached DASH complex to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids (PubMed:16415853, PubMed:16777964). Incorrect microtubule attachments are corrected by releasing microubules from the kinetochore through phosphorylation by IPL1 of kinetochore components (PubMed:12408861). Links the microtubule cytoskeleton to chromosomes during interphase (PubMed:36701236). Also contributes to the poleward transport of kinetochores on microtubules following centromeric DNA replication in S-phase (PubMed:18079178)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXA0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005876 spindle microtubule;GO:0072686 mitotic spindle;GO:0042729 DASH complex", "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0031116 positive regulation of microtubule polymerization;GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore;GO:1990758 mitotic sister chromatid biorientation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P36131-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36132-1", "uniprot_id": [ { "id": "KAE1_YEAST", "url": "https://www.uniprot.org/uniprot/P36132", "type": "external" } ], "mass": 42748.0, "length": 386, "protein_name": "tRNA N6-adenosine threonylcarbamoyltransferase", "gene_name": "KAE1", "organism": "Yeast", "refseq_name": "tRNA N6-adenosine threonylcarbamoyltransferase", "refseq_ac": [ { "id": "NP_012964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012964", "type": "external" } ], "gene_names_uniprotkb": "KAE1", "gene_names_refseq": "KAE1", "protein_names_uniprotkb": "tRNA N6-adenosine threonylcarbamoyltransferase; 2.3.1.234; Kinase-associated endopeptidase 1; N6-L-threonylcarbamoyladenine synthase; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein KAE1; tRNA threonylcarbamoyladenosine biosynthesis protein KAE1", "protein_names_refseq": "tRNA N6-adenosine threonylcarbamoyltransferase", "tax_id": 559292, "disease": "primary hypomagnesemia (Disease Ontology:DOID:0060879); Galloway-Mowat syndrome 3 (Disease Ontology:DOID:0080245); proteinuria (Disease Ontology:DOID:576)", "pathway": " (sce:YKR038C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12748633;14519092;14562095;14562106;14690591;16564010;16874308;18407956;21183954;21285948;21459853;23258706;23620299;24374639;8196765", "class_list": "", "function": "Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators., [UniProtKB, PubMed, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VXA1", "ec_number_list": [ { "id": "2.3.1.234", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.234", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0008252 nucleotidase activity;GO:0046872 metal ion binding;GO:0031490 chromatin DNA binding;GO:0061711 tRNA N(6)-L-threonylcarbamoyladenine synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0000408 EKC/KEOPS complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006400 tRNA modification;GO:0000723 telomere maintenance;GO:1990145 maintenance of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P36132-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36135-1", "uniprot_id": [ { "id": "UTH1_YEAST", "url": "https://www.uniprot.org/uniprot/P36135", "type": "external" } ], "mass": 36955.0, "length": 365, "protein_name": "Probable secreted beta-glucosidase UTH1", "gene_name": "UTH1", "organism": "Yeast", "refseq_name": "SUN family protein UTH1", "refseq_ac": [ { "id": "NP_012968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012968", "type": "external" } ], "gene_names_uniprotkb": "UTH1", "gene_names_refseq": "UTH1", "protein_names_uniprotkb": "Probable secreted beta-glucosidase UTH1; 3.2.1.-; Youth protein 1", "protein_names_refseq": "SUN family protein UTH1", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR042W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10612745;10683261;10870102;11958935;12519199;12748633;14562106;15247238;15905473;17377488;24040106;24374639;7859289;8196765;9799359", "class_list": "glycogene;glycosylhydrolase", "function": "Involved in aging, oxidative stress response, and in the regulation of mitochondrial biogenesis. Inactivation of UTH1 increases life span, leads to higher resistance to heat stress and against hydrogen peroxide, and increases sensitivity to the superoxide radical-generating drug paraquat and to copper. Also required for the selective autophagic degradation of mitochondria (mitophagy) in response to nitrogen starvation. Involved in the remodeling of the cell wall during the various phases of yeast culture development and under various environmental conditions and plays a role in septation. Involved in cell sensitivity to boric acid., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXA4", "ec_number_list": [], "go_molecular_function": "GO:0016798 hydrolase activity, acting on glycosyl bonds", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0009986 cell surface;GO:0009277 fungal-type cell wall", "go_biological_process": "GO:0000422 autophagy of mitochondrion;GO:0000272 polysaccharide catabolic process;GO:0000917 division septum assembly;GO:0009272 fungal-type cell wall biogenesis;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P36135-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36136-1", "uniprot_id": [ { "id": "SHB17_YEAST", "url": "https://www.uniprot.org/uniprot/P36136", "type": "external" } ], "mass": 31022.0, "length": 271, "protein_name": "Sedoheptulose 1,7-bisphosphatase", "gene_name": "SHB17", "organism": "Yeast", "refseq_name": "sedoheptulose-bisphosphatase", "refseq_ac": [ { "id": "NP_012969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012969", "type": "external" } ], "gene_names_uniprotkb": "SHB17", "gene_names_refseq": "SHB17", "protein_names_uniprotkb": "Sedoheptulose 1,7-bisphosphatase; 3.1.3.37", "protein_names_refseq": "sedoheptulose-bisphosphatase", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR043C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;20427268;21126336;21663798;24374639;33481703;33491328;8196765", "class_list": "", "function": "Sedoheptulose 1,7-bisphosphatase involved in riboneogenesis. Dephosphorylates sedoheptulose 1,7-bisphosphate (SBP), which is converted via the non-oxidative pentose phosphate pathway to ribose-5-phosphate. Has a fructose 1,6-bisphosphatase activity in vitro, but this is probably not biologically relevant, since deletion does not affect fructose 1,6-biphosphate (FBP) levels., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXA5", "ec_number_list": [ { "id": "3.1.3.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.37", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0050278 sedoheptulose-bisphosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0046390 ribose phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P36136-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36143-1", "uniprot_id": [ { "id": "GLG1_YEAST", "url": "https://www.uniprot.org/uniprot/P36143", "type": "external" } ], "mass": 69724.0, "length": 616, "protein_name": "Glycogenin-1", "gene_name": "GLG1", "organism": "Yeast", "refseq_name": "glycogenin glucosyltransferase GLG1", "refseq_ac": [ { "id": "NP_012984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012984", "type": "external" } ], "gene_names_uniprotkb": "GLG1", "gene_names_refseq": "GLG1", "protein_names_uniprotkb": "Glycogenin-1; 2.4.1.186; Glycogen synthesis initiator protein 1; Glycogenin glucosyltransferase 1", "protein_names_refseq": "glycogenin glucosyltransferase GLG1", "tax_id": 559292, "disease": "glycogen storage disease XV (Disease Ontology:DOID:0050579); glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (sce:YKR058W); (R-SCE-3322077); (R-SCE-6798695); (R-SCE-70221)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10077186;12775844;12844361;19779198;23749301;24374639;33491328;38832010;8196765;8524228;8900126", "class_list": "", "function": "Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase. Capable of transferring glucosyl residues to unbound acceptors such as free oligoglucans or oligoglucan derivatives., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VXB9", "ec_number_list": [ { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.4.23.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.25", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.4.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.11", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.7.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.59", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.3.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10", "type": "external" } ], "go_molecular_function": "GO:0008466 glycogenin glucosyltransferase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005773 vacuole", "go_biological_process": "GO:0005978 glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P36143-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36146-1", "uniprot_id": [ { "id": "LAS1_YEAST", "url": "https://www.uniprot.org/uniprot/P36146", "type": "external" } ], "mass": 59351.0, "length": 502, "protein_name": "Protein LAS1", "gene_name": "LAS1", "organism": "Yeast", "refseq_name": "rRNA-processing protein LAS1", "refseq_ac": [ { "id": "NP_012989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012989", "type": "external" } ], "gene_names_uniprotkb": "LAS1", "gene_names_refseq": "LAS1", "protein_names_uniprotkb": "Protein LAS1", "protein_names_refseq": "rRNA-processing protein LAS1", "tax_id": 559292, "disease": "Wilson-Turner syndrome (Disease Ontology:DOID:0060814)", "pathway": " (sce:YKR063C); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14562106;14576278;17322287;18407956;19779198;24374639;32597660;33481703;33491328;8196765;8582632", "class_list": "", "function": "Regulates cell surface growth, bud formation and morphogenesis. May act indirectly by regulating factor(s) involved in these processes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXC4;Q66R55", "ec_number_list": [], "go_molecular_function": "GO:0004519 endonuclease activity;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0000460 maturation of 5.8S rRNA;GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P36146-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36148-1", "uniprot_id": [ { "id": "GPT2_YEAST", "url": "https://www.uniprot.org/uniprot/P36148", "type": "external" } ], "mass": 83645.0, "length": 743, "protein_name": "Glycerol-3-phosphate O-acyltransferase 2", "gene_name": "GPT2", "organism": "Yeast", "refseq_name": "bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2", "refseq_ac": [ { "id": "NP_012993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012993", "type": "external" } ], "gene_names_uniprotkb": "GPT2; GAT1", "gene_names_refseq": "GAT1; GPT2", "protein_names_uniprotkb": "Glycerol-3-phosphate O-acyltransferase 2; 2.3.1.15; 2.3.1.42; DHAP-AT 2; Dihydroxyacetone phosphate acyltransferase 2; G-3-P acyltransferase 2; GPAT 2; Glycerol-3-phosphate / dihydroxyacetone phosphate acyltransferase 2", "protein_names_refseq": "bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR067W)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10049376;11544256;12167660;14562106;15665377;16847258;17330950;17563356;18407956;19525420;19684113;19779198;20702584;21126336;21177495;22218487;22267742;23749301;24374639;29073188;30516470;31421179;32597660;33481703;33491328;8196765;9401016", "class_list": "", "function": "Dual substrate-specific glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase, catalyzing the first and committed reaction in the de novo synthesis of glycerophospholipids and triacylglycerols (TAGs). Can use both Gly-3-P and dihydroxyacetone phosphate with similar efficiencies and has a broad fatty acyl-CoA specificity profile. Transfers a fatty acid from fatty acyl-CoA to the sn-1 position of glycerol-3-phosphate to produce lysophosphatidic acid (LysoPA). These lipids not only are precursors of glycerolipids, but also are dynamic components of signal transduction systems that control cell physiology., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXC8", "ec_number_list": [ { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" } ], "go_molecular_function": "GO:0016287 glycerone-phosphate O-acyltransferase activity;GO:0004366 glycerol-3-phosphate O-acyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008654 phospholipid biosynthetic process;GO:0090207 regulation of triglyceride metabolic process;GO:0016024 CDP-diacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P36148-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36149-1", "uniprot_id": [ { "id": "BET3_YEAST", "url": "https://www.uniprot.org/uniprot/P36149", "type": "external" } ], "mass": 22129.0, "length": 193, "protein_name": "Trafficking protein particle complex subunit BET3", "gene_name": "BET3", "organism": "Yeast", "refseq_name": "TRAPP complex core subunit BET3", "refseq_ac": [ { "id": "NP_012994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012994", "type": "external" } ], "gene_names_uniprotkb": "BET3", "gene_names_refseq": "BET3", "protein_names_uniprotkb": "Trafficking protein particle complex subunit BET3; TRAPP subunit BET3; Transport protein particle 22 kDa subunit", "protein_names_refseq": "TRAPP complex core subunit BET3", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR068C); (R-SCE-204005); (R-SCE-8876198)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "11239471;14562106;15692564;17322287;20375281;20972447;22814378;24374639;33491328;8196765;8590804;9564032", "class_list": "", "function": "Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation. Required for sporulation. Has a role late in meiosis following DNA replication., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXC9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0000407 phagophore assembly site;GO:1990072 TRAPPIII protein complex;GO:1990070 TRAPPI protein complex", "go_biological_process": "GO:0016236 macroautophagy;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0006995 cellular response to nitrogen starvation;GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P36149-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36156-1", "uniprot_id": [ { "id": "GSTO2_YEAST", "url": "https://www.uniprot.org/uniprot/P36156", "type": "external" } ], "mass": 43274.0, "length": 370, "protein_name": "Glutathione S-transferase omega-like 2", "gene_name": "ECM4", "organism": "Yeast", "refseq_name": "S-glutathionyl-(chloro)hydroquinone reductase", "refseq_ac": [ { "id": "NP_013002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013002", "type": "external" } ], "gene_names_uniprotkb": "ECM4; GTO2", "gene_names_refseq": "ECM4; GTO2", "protein_names_uniprotkb": "Glutathione S-transferase omega-like 2; 1.8.5.1; 2.5.1.18; Extracellular mutant protein 4; Glutathione-dependent dehydroascorbate reductase", "protein_names_refseq": "S-glutathionyl-(chloro)hydroquinone reductase", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR076W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;16709151;16936141;24374639;27736955;33491328;8196765;9335584", "class_list": "", "function": "Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). May be involved in cell wall organization and biogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXD6", "ec_number_list": [ { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0045174 glutathione dehydrogenase (ascorbate) activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006749 glutathione metabolic process;GO:0071555 cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P36156-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36159-1", "uniprot_id": [ { "id": "RNZ_YEAST", "url": "https://www.uniprot.org/uniprot/P36159", "type": "external" } ], "mass": 96816.0, "length": 838, "protein_name": "Ribonuclease Z", "gene_name": "TRZ1", "organism": "Yeast", "refseq_name": "tRNase Z", "refseq_ac": [ { "id": "NP_013005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013005", "type": "external" } ], "gene_names_uniprotkb": "TRZ1", "gene_names_refseq": "TRZ1", "protein_names_uniprotkb": "Ribonuclease Z; 3.1.26.11; RNase Z; tRNA 3 endonuclease; tRNase Z", "protein_names_refseq": "tRNase Z", "tax_id": 559292, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); combined oxidative phosphorylation deficiency 17 (Disease Ontology:DOID:0111496); infantile hypertrophic cardiomyopathy (Disease Ontology:DOID:0111753); prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (sce:YKR079C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12711671;14562095;14562106;14690591;17330950;18407956;19779198;24374639;33481703;33491328;8196765", "class_list": "", "function": "Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXD9", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0042781 3'-tRNA processing endoribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0042780 tRNA 3'-end processing;GO:1990180 mitochondrial tRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P36159-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36161-1", "uniprot_id": [ { "id": "NU133_YEAST", "url": "https://www.uniprot.org/uniprot/P36161", "type": "external" } ], "mass": 133321.0, "length": 1157, "protein_name": "Nucleoporin NUP133", "gene_name": "NUP133", "organism": "Yeast", "refseq_name": "Nup133p", "refseq_ac": [ { "id": "NP_013008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013008", "type": "external" } ], "gene_names_uniprotkb": "NUP133; RAT3; YKR402", "gene_names_refseq": "NUP133; RAT3", "protein_names_uniprotkb": "Nucleoporin NUP133; Nuclear pore protein NUP133", "protein_names_refseq": "Nup133p", "tax_id": 559292, "disease": "Galloway-Mowat syndrome 1 (Disease Ontology:DOID:0060364); nephrotic syndrome type 18 (Disease Ontology:DOID:0080393); Galloway-Mowat syndrome (Disease Ontology:DOID:0080694)", "pathway": " (sce:YKR082W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10684247;11071906;11823431;12730220;12791264;14562106;18407956;22814378;23749301;24374639;32597660;33491328;7813444;7862658;8196765;8203164;8524308;9049242", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP133 is involved in nuclear poly(A)+ RNA, tRNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXE2", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005829 cytosol", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0031509 subtelomeric heterochromatin formation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006409 tRNA export from nucleus;GO:0006913 nucleocytoplasmic transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P36161-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36162-1", "uniprot_id": [ { "id": "DAD2_YEAST", "url": "https://www.uniprot.org/uniprot/P36162", "type": "external" } ], "mass": 15072.0, "length": 133, "protein_name": "DASH complex subunit DAD2", "gene_name": "DAD2", "organism": "Yeast", "refseq_name": "Dad2p", "refseq_ac": [ { "id": "NP_013009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013009", "type": "external" } ], "gene_names_uniprotkb": "DAD2; HSK1; YKR403", "gene_names_refseq": "DAD2; HSK1", "protein_names_uniprotkb": "DASH complex subunit DAD2; DUO1 and DAM1-interacting protein 2; Helper of ASK1 protein 1; Outer kinetochore protein DAD2", "protein_names_refseq": "Dad2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR083C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "11782438;11799062;12408861;14562095;14562106;15640796;15664196;16415853;16715078;16777964;17322287;17460120;17643123;18079178;22814378;24374639;24930965;25236177;36701236;8196765;8203164", "class_list": "", "function": "Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerization to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase (PubMed:15664196, PubMed:16415853, PubMed:16777964, PubMed:17460120, PubMed:17643123). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules (PubMed:11782438). Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle (PubMed:11782438, PubMed:12408861). During spindle-kinetochore attachment, kinetochores first attach to the lateral surface of spindle microtubules, which supports the congression of chromosomes toward the middle of the dividing cell; they then slide along towards the spindle pole, a process independent of the DASH complex but requiring the NDC80 complex (PubMed:25236177). When the end of a disassembling microtubule reaches the laterally attached kinetochore, the DASH complex together with the NDC80 complex and STU2 convert lateral attachment to end-on capture to produce a structure that can track with microtubule shortening and sustain attachment when tension is applied across sister kinetochores upon their biorientation (PubMed:15640796, PubMed:15664196, PubMed:25236177). Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached DASH complex to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids (PubMed:16415853, PubMed:16777964). Incorrect microtubule attachments are corrected by releasing microubules from the kinetochore through phosphorylation by IPL1 of kinetochore components (PubMed:12408861). Links the microtubule cytoskeleton to chromosomes during interphase (PubMed:36701236). Also contributes to the poleward transport of kinetochores on microtubules following centromeric DNA replication in S-phase (PubMed:18079178)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXE3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005874 microtubule;GO:0072686 mitotic spindle;GO:1990023 mitotic spindle midzone;GO:0042729 DASH complex;GO:0044732 mitotic spindle pole body", "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0031116 positive regulation of microtubule polymerization;GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore;GO:1990758 mitotic sister chromatid biorientation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P36162-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36165-1", "uniprot_id": [ { "id": "TGL4_YEAST", "url": "https://www.uniprot.org/uniprot/P36165", "type": "external" } ], "mass": 102717.0, "length": 910, "protein_name": "Triacylglycerol lipase 4", "gene_name": "TGL4", "organism": "Yeast", "refseq_name": "triacylglycerol lipase", "refseq_ac": [ { "id": "NP_013015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013015", "type": "external" } ], "gene_names_uniprotkb": "TGL4; STC1; YKR409", "gene_names_refseq": "TGL4", "protein_names_uniprotkb": "Triacylglycerol lipase 4; 3.1.1.3; Lipase 4", "protein_names_refseq": "triacylglycerol lipase", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR089C)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "14562095;14562106;15665377;16135509;16267052;17287358;17563356;18407956;19150427;19779198;19795423;19823750;20332534;21126336;21177495;21820081;23749301;24374639;24868093;27170177;32597660;33481703;33491328;8196765;8203164", "class_list": "", "function": "Lipid particle-localized triacylglycerol (TAG) lipase. The lipid droplet/particle is a lipid storage compartment which serves as a depot of energy and building blocks for membrane lipid biosynthesis. Involved in the mobilization of the non-polar storage lipids triacylglycerols (TAGs) from lipid particles by hydrolysis of TAGs, releasing and supplying specific fatty acids to the appropriate metabolic pathways (PubMed:16135509, PubMed:16267052). Also has steryl ester (SE) hydrolase and phospholipase A(2) (PLA(2)) activities, and catalyzes the acylation of lysophosphatidic acid (LPA) (PubMed:20332534). Contributes to early bud formation in late G1 phase of the cell cycle upon phosphorylation and activation by cyclin-dependent kinase 1 (Cdk1/CDC28) (PubMed:19150427)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 33, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXE9", "ec_number_list": [ { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "1.1.1.101", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.101", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" } ], "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005811 lipid droplet", "go_biological_process": "GO:0019433 triglyceride catabolic process;GO:0006642 triglyceride mobilization;GO:0006644 phospholipid metabolic process;GO:0007114 cell budding;GO:0030435 sporulation resulting in formation of a cellular spore", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P36165-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36170-1", "uniprot_id": [ { "id": "FLO10_YEAST", "url": "https://www.uniprot.org/uniprot/P36170", "type": "external" } ], "mass": 122165.0, "length": 1169, "protein_name": "Flocculation protein FLO10", "gene_name": "FLO10", "organism": "Yeast", "refseq_name": "Flo10p", "refseq_ac": [ { "id": "NP_013028", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013028", "type": "external" } ], "gene_names_uniprotkb": "FLO10", "gene_names_refseq": "FLO10", "protein_names_uniprotkb": "Flocculation protein FLO10; Flocculin-10", "protein_names_refseq": "Flo10p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR102W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11027318;15016375;16086015;24374639;7502576;8196765", "class_list": "", "function": "Cell wall protein that participates directly in adhesive cell-cell interactions during yeast flocculation, a reversible, asexual and Ca(2+)-dependent process in which cells adhere to form aggregates (flocs) consisting of thousands of cells. The lectin-like protein sticks out of the cell wall of flocculent cells and selectively binds mannose residues in the cell walls of adjacent cells. Activity is inhibited by mannose, glucose, maltose and sucrose. Also involved in cell-substrate adhesion, haploid invasive growth and diploid pseudohyphae formation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 12, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "D6VXG3", "ec_number_list": [], "go_molecular_function": "GO:0005537 D-mannose binding", "go_cellular_component": "GO:0071944 cell periphery;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0000128 flocculation;GO:0001403 invasive growth in response to glucose limitation;GO:0044182 filamentous growth of a population of unicellular organisms", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P36170-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36224-1", "uniprot_id": [ { "id": "JNM1_YEAST", "url": "https://www.uniprot.org/uniprot/P36224", "type": "external" } ], "mass": 43607.0, "length": 373, "protein_name": "Nuclear migration protein JNM1", "gene_name": "JNM1", "organism": "Yeast", "refseq_name": "Jnm1p", "refseq_ac": [ { "id": "NP_014022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014022", "type": "external" } ], "gene_names_uniprotkb": "JNM1; INS1", "gene_names_refseq": "INS1; JNM1; PAC3", "protein_names_uniprotkb": "Nuclear migration protein JNM1", "protein_names_refseq": "Jnm1p", "tax_id": 559292, "disease": "synucleinopathy (Disease Ontology:DOID:0050890); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (sce:YMR294W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "15311283;15975903;16291862;18407956;23749301;24374639;32597660;33491328;8138567;9169872;9658168", "class_list": "", "function": "Component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding (By similarity). The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. JNM1 is associated with the rod and links it to the projecting sidearm. Required for proper nuclear migration during the mitotic cell cycle and for astral microtubule development., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0C1", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0015629 actin cytoskeleton;GO:0005869 dynactin complex;GO:0030286 dynein complex", "go_biological_process": "GO:0030048 actin filament-based movement;GO:0000132 establishment of mitotic spindle orientation;GO:0007052 mitotic spindle organization;GO:0007097 nuclear migration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P36224-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36421-1", "uniprot_id": [ { "id": "SYYC_YEAST", "url": "https://www.uniprot.org/uniprot/P36421", "type": "external" } ], "mass": 44020.0, "length": 394, "protein_name": "Tyrosine--tRNA ligase, cytoplasmic", "gene_name": "TYS1", "organism": "Yeast", "refseq_name": "tyrosine--tRNA ligase TYS1", "refseq_ac": [ { "id": "NP_011701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011701", "type": "external" } ], "gene_names_uniprotkb": "TYS1; G7522; MGM104", "gene_names_refseq": "TTS1; TYS1", "protein_names_uniprotkb": "Tyrosine--tRNA ligase, cytoplasmic; 6.1.1.1; TyrRS; Tyrosyl-tRNA synthetase", "protein_names_refseq": "tyrosine--tRNA ligase TYS1", "tax_id": 559292, "disease": "Charcot-Marie-Tooth disease dominant intermediate C (Disease Ontology:DOID:0110199); multisystem proteinopathy (Disease Ontology:DOID:070355); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); cancer (Disease Ontology:DOID:162); neuropathy (Disease Ontology:DOID:870)", "pathway": " (sce:YGR185C)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10588711;10677221;10766779;11359929;11410349;11530018;11875433;14562095;14562106;17576676;18407956;19779198;19795423;19823750;21126336;23749301;24374639;32597660;328277;33481703;33491328;3535890;36307205;7995524;8509419;9133739;9169869;9294037", "class_list": "", "function": "Catalyzes the attachment of L-tyrosine to tRNA(Tyr) in a two-step reaction: L-tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (PubMed:10588711, PubMed:10677221, PubMed:10766779, PubMed:3535890, PubMed:8509419). The specificity determinants on tRNA(Tyr) are the base pair C1-G72, the discriminator residue A73, and the three anticodon bases G34, U35 and A36 (PubMed:10677221). Also involved in nuclear tRNA export (PubMed:10588711). Also attaches D-Tyr to tRNA(Tyr), this reaction is about 150-fold less efficient than attachment of L-Tyr (PubMed:10766779)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUW8", "ec_number_list": [ { "id": "6.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.1", "type": "external" } ], "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0004831 tyrosine-tRNA ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006437 tyrosyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P36421-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36531-1", "uniprot_id": [ { "id": "RM36_YEAST", "url": "https://www.uniprot.org/uniprot/P36531", "type": "external" } ], "mass": 20091.0, "length": 177, "protein_name": "Large ribosomal subunit protein bL31m", "gene_name": "MRPL36", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein bL31m MRPL36", "refseq_ac": [ { "id": "NP_009680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009680", "type": "external" } ], "gene_names_uniprotkb": "MRPL36; YBR0918", "gene_names_refseq": "MRPL36; bL31m", "protein_names_uniprotkb": "Large ribosomal subunit protein bL31m; 54S ribosomal protein L36, mitochondrial; YmL36", "protein_names_refseq": "mitochondrial 54S ribosomal protein bL31m MRPL36", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR122C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11259585;12392552;12748633;14562095;14576278;15166137;2060626;24374639;24675956;25609543;7813418;7900426", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:24675956, PubMed:25609543). Overexpression of bL31m suppresses mutations in the COX2 leader peptide-encoding and initiation codon regions (PubMed:11259585, PubMed:15166137)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQC0", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P36531-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36775-1", "uniprot_id": [ { "id": "LONM_YEAST", "url": "https://www.uniprot.org/uniprot/P36775", "type": "external" } ], "mass": 127112.0, "length": 1133, "protein_name": "Lon protease homolog, mitochondrial", "gene_name": "PIM1", "organism": "Yeast", "refseq_name": "ATP-dependent Lon protease PIM1", "refseq_ac": [ { "id": "NP_009531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009531", "type": "external" } ], "gene_names_uniprotkb": "PIM1; LON; YBL0440", "gene_names_refseq": "PIM1", "protein_names_uniprotkb": "Lon protease homolog, mitochondrial; 3.4.21.53", "protein_names_refseq": "ATP-dependent Lon protease PIM1", "tax_id": 559292, "disease": "CODAS syndrome (Disease Ontology:DOID:0111274); brain ischemia (Disease Ontology:DOID:2316); ischemia (Disease Ontology:DOID:326)", "pathway": " (sce:YBL022C); (R-SCE-9837999)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10359790;14562095;14562106;15870080;16428434;20150421;21126336;24374639;2832732;28377575;32597660;33491328;35143841;36269765;7813418;8146662;8276800;8354406;8810243;9405361;9724747", "class_list": "", "function": "ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner (PubMed:15870080, PubMed:16428434, PubMed:35143841, PubMed:8146662, PubMed:8276800, PubMed:8354406, PubMed:8810243, PubMed:9405361, PubMed:9724747). Endogenous substrates include ABF2, ACO2, ILV1, ILV2, LSC1, LYS4, MGM101 and several oxidized proteins. The 2 nucleic acid-binding proteins ABF2 and MGM101 are protected from degradation by PIM1 when they are bound to DNA (PubMed:16428434, PubMed:20150421, PubMed:28377575)., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VPX8;P13435", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.2.4", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.1", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "1.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.4", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "1.2.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.41", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0043565 sequence-specific DNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0033108 mitochondrial respiratory chain complex assembly;GO:0034599 cellular response to oxidative stress;GO:0006457 protein folding;GO:0007005 mitochondrion organization;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P36775-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37012-1", "uniprot_id": [ { "id": "PGM2_YEAST", "url": "https://www.uniprot.org/uniprot/P37012", "type": "external" } ], "mass": 63089.0, "length": 569, "protein_name": "Phosphoglucomutase 2", "gene_name": "PGM2", "organism": "Yeast", "refseq_name": "phosphoglucomutase PGM2", "refseq_ac": [ { "id": "NP_013823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013823", "type": "external" } ], "gene_names_uniprotkb": "PGM2; GA-5; GAL5; YM9718.04C", "gene_names_refseq": "GAL5; PGM2", "protein_names_uniprotkb": "Phosphoglucomutase 2; 5.4.2.2; D-glucose-1,6-diphosphate:D-glucose-1-phosphate phosphotransferase; Glucose phosphomutase 2; PGM 2", "protein_names_refseq": "phosphoglucomutase PGM2", "tax_id": 559292, "disease": "congenital disorder of glycosylation It (Disease Ontology:DOID:0080570); endometrial cancer (Disease Ontology:DOID:1380); teratoma (Disease Ontology:DOID:3307)", "pathway": " (sce:YMR105C); (R-SCE-3322077); (R-SCE-6798695); (R-SCE-70221); (R-SCE-70370)", "pathway_count": 5, "publication_count": 31, "publication_id_list": "1100398;13887540;14264884;14562106;15665377;17322287;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21177495;2138705;22218487;22814378;23103740;23749301;24374639;32597660;33481703;33491328;4628805;4992300;5231755;5784209;7929458;8119301;8385141;9169872", "class_list": "", "function": "Major phosphoglucomutase isozyme that catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:1100398, PubMed:23103740, PubMed:4992300, PubMed:5784209). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable). Constitutes about 80-90% of the phosphoglucomutase activity in the cell (PubMed:14264884, PubMed:5231755). Key enzyme in hexose metabolism. The forward reaction is an essential step in the energy metabolism of galactose since the product of the galactose pathway enzymes in yeast is glucose 1-phosphate. The reverse reaction is an essential step for biosynthesis when carbon sources other than galactose are the energy source because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose (PubMed:14264884)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZS7", "ec_number_list": [ { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.4.23.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.25", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.7.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.59", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.3.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004614 phosphoglucomutase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006874 intracellular calcium ion homeostasis;GO:0006006 glucose metabolic process;GO:0005978 glycogen biosynthetic process;GO:0019255 glucose 1-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P37012-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37020-1", "uniprot_id": [ { "id": "GEF1_YEAST", "url": "https://www.uniprot.org/uniprot/P37020", "type": "external" } ], "mass": 87592.0, "length": 779, "protein_name": "Anion/proton exchange transporter GEF1", "gene_name": "GEF1", "organism": "Yeast", "refseq_name": "Gef1p", "refseq_ac": [ { "id": "NP_012574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012574", "type": "external" } ], "gene_names_uniprotkb": "GEF1; CLCY1; J1616", "gene_names_refseq": "CLC; GEF1", "protein_names_uniprotkb": "Anion/proton exchange transporter GEF1; CLC protein GEF1; ClC-A; ClC-Y1; Voltage-gated chloride channel", "protein_names_refseq": "Gef1p", "tax_id": 559292, "disease": "Dent disease (Disease Ontology:DOID:0050699); X-linked recessive hypophosphatemic rickets (Disease Ontology:DOID:0080353); Dent disease 1 (Disease Ontology:DOID:0081453); neuronal ceroid lipofuscinosis 3 (Disease Ontology:DOID:0110731); X-linked nephrolithiasis type I (Disease Ontology:DOID:0111798); low molecular weight proteinuria with hypercalciuric nephrocalcinosis (Disease Ontology:DOID:0111815); Raynaud-Claes syndrome (Disease Ontology:DOID:0112060); osteopetrosis (Disease Ontology:DOID:13533); renal tubular transport disease (Disease Ontology:DOID:447)", "pathway": " (sce:YJR040W); (R-SCE-2672351)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "12074596;15710404;16260785;16847258;17662057;18407956;24374639;33491328;7505388;7668047;7932715;8641269;9520490;9614122", "class_list": "", "function": "Anion/proton exchange transporter involved in iron and copper cation homeostasis. Involved in intracellular iron metabolism during growth on fermentable and non fermentable carbon sources. Required for proper copper-loading and maturation of multicopper oxidase FET3. Important for adjusting intracellular compartment pH to more alkaline pH under iron limitation. May also transport chloride ions through the plasma membrane., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VWL1", "ec_number_list": [], "go_molecular_function": "GO:0005247 voltage-gated chloride channel activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006878 intracellular copper ion homeostasis;GO:0006879 intracellular iron ion homeostasis;GO:0034756 regulation of iron ion transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P37020-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37254-1", "uniprot_id": [ { "id": "ADCS_YEAST", "url": "https://www.uniprot.org/uniprot/P37254", "type": "external" } ], "mass": 88544.0, "length": 787, "protein_name": "Aminodeoxychorismate synthase", "gene_name": "ABZ1", "organism": "Yeast", "refseq_name": "4-amino-4-deoxychorismate synthase", "refseq_ac": [ { "id": "NP_014431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014431", "type": "external" } ], "gene_names_uniprotkb": "ABZ1; N3286", "gene_names_refseq": "ABZ1", "protein_names_uniprotkb": "Aminodeoxychorismate synthase; 2.6.1.85; ADC synthase; P-aminobenzoic acid synthase; PABA synthase; Para-aminobenzoate synthase", "protein_names_refseq": "4-amino-4-deoxychorismate synthase", "tax_id": 559292, "disease": "", "pathway": " (sce:YNR033W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;17322287;19779198;24374639;33491328;8346682;8725220;9169873", "class_list": "", "function": "Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. Required for the synthesis of 4-aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1K8;Q02982;Q6B1Q1", "ec_number_list": [ { "id": "2.6.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.85", "type": "external" } ], "go_molecular_function": "GO:0046820 4-amino-4-deoxychorismate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0046654 tetrahydrofolate biosynthetic process;GO:0008153 4-aminobenzoate biosynthetic process;GO:0046656 folic acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P37254-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37291-1", "uniprot_id": [ { "id": "GLYC_YEAST", "url": "https://www.uniprot.org/uniprot/P37291", "type": "external" } ], "mass": 52218.0, "length": 469, "protein_name": "Serine hydroxymethyltransferase, cytosolic", "gene_name": "SHM2", "organism": "Yeast", "refseq_name": "glycine hydroxymethyltransferase SHM2", "refseq_ac": [ { "id": "NP_013159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013159", "type": "external" } ], "gene_names_uniprotkb": "SHM2; L2156; SHMT2", "gene_names_refseq": "SHM2; SHMT2", "protein_names_uniprotkb": "Serine hydroxymethyltransferase, cytosolic; 2.1.2.1; Glycine hydroxymethyltransferase; SHMT; Serine methylase", "protein_names_refseq": "glycine hydroxymethyltransferase SHM2", "tax_id": 559292, "disease": "neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities (Disease Ontology:DOID:0070543); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); ovarian cancer (Disease Ontology:DOID:2394); schizophrenia (Disease Ontology:DOID:5419); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (sce:YLR058C); (R-SCE-196757); (R-SCE-71262); (R-SCE-9837999)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "14562106;18407956;19779198;21126336;22106047;23749301;24374639;32597660;33481703;33491328;8132653;9169871;9509572", "class_list": "", "function": "Interconversion of serine and glycine., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY60", "ec_number_list": [ { "id": "1.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.2.4", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.1", "type": "external" }, { "id": "1.2.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.41", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004372 glycine hydroxymethyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0043332 mating projection tip", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0006730 one-carbon metabolic process;GO:0040029 epigenetic regulation of gene expression;GO:0035999 tetrahydrofolate interconversion;GO:0046653 tetrahydrofolate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P37291-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37292-1", "uniprot_id": [ { "id": "GLYM_YEAST", "url": "https://www.uniprot.org/uniprot/P37292", "type": "external" } ], "mass": 53686.0, "length": 490, "protein_name": "Serine hydroxymethyltransferase, mitochondrial", "gene_name": "SHM1", "organism": "Yeast", "refseq_name": "glycine hydroxymethyltransferase SHM1", "refseq_ac": [ { "id": "NP_009822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009822", "type": "external" } ], "gene_names_uniprotkb": "SHM1; SHMT1; YBR1732", "gene_names_refseq": "SHM1; SHMT1; TMP3", "protein_names_uniprotkb": "Serine hydroxymethyltransferase, mitochondrial; 2.1.2.1; Glycine hydroxymethyltransferase; SHMT; Serine methylase", "protein_names_refseq": "glycine hydroxymethyltransferase SHM1", "tax_id": 559292, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); ovarian cancer (Disease Ontology:DOID:2394); schizophrenia (Disease Ontology:DOID:5419); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (sce:YBR263W); (R-SCE-196757); (R-SCE-71262)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "14562106;18086883;23749301;24374639;33481703;33491328;7813418;8132653;8465606", "class_list": "", "function": "Interconversion of serine and glycine., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQR0", "ec_number_list": [ { "id": "2.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.1", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004372 glycine hydroxymethyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0035999 tetrahydrofolate interconversion;GO:0046653 tetrahydrofolate metabolic process;GO:0019264 glycine biosynthetic process from serine", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P37292-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37296-1", "uniprot_id": [ { "id": "VPP2_YEAST", "url": "https://www.uniprot.org/uniprot/P37296", "type": "external" } ], "mass": 101661.0, "length": 890, "protein_name": "V-type proton ATPase subunit a, Golgi isoform", "gene_name": "STV1", "organism": "Yeast", "refseq_name": "H(+)-transporting V0 sector ATPase subunit a", "refseq_ac": [ { "id": "NP_013770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013770", "type": "external" } ], "gene_names_uniprotkb": "STV1; YM9796.07", "gene_names_refseq": "STV1", "protein_names_uniprotkb": "V-type proton ATPase subunit a, Golgi isoform; Similar to VPH1 protein 1; V-ATPase 101 kDa subunit; V-ATPase a 2 subunit; V-ATPase subunit AC115; Vacuolar proton translocating ATPase subunit a 2", "protein_names_refseq": "H(+)-transporting V0 sector ATPase subunit a", "tax_id": 559292, "disease": "autosomal recessive distal renal tubular acidosis 3 with or without sensorineural hearing loss (Disease Ontology:DOID:0061166); autosomal recessive cutis laxa type IIA (Disease Ontology:DOID:0070134); developmental and epileptic encephalopathy 104 (Disease Ontology:DOID:0070390); autosomal recessive osteopetrosis 1 (Disease Ontology:DOID:0110942); wrinkly skin syndrome (Disease Ontology:DOID:0112171); clubfoot (Disease Ontology:DOID:11836); renal tubular acidosis (Disease Ontology:DOID:14219); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (sce:YMR054W); (R-SCE-1222556); (R-SCE-6798695); (R-SCE-77387); (R-SCE-917977); (R-SCE-9639288)", "pathway_count": 6, "publication_count": 22, "publication_id_list": "11278748;14562095;14562106;15665377;16847258;17330950;17563356;18407956;19684113;19779198;20702584;21126336;21177495;22218487;22814378;23749301;24374639;32597660;33481703;33491328;7514599;9169872", "class_list": "", "function": "Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:11278748, PubMed:7514599). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:11278748, PubMed:7514599). Is present only in Golgi- and endosome-residing V-ATPase complexes; enzymes containing this subunit have a 4-fold lower ratio of proton transport to ATP hydrolysis than complexes containing the vacuolar isoform and do not dissociate V1 and V0 in response to glucose depletion (PubMed:11278748, PubMed:7514599)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZM9", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005770 late endosome;GO:0010008 endosome membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex", "go_biological_process": "GO:0048388 endosomal lumen acidification;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport;GO:0061795 Golgi lumen acidification", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P37296-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37297-1", "uniprot_id": [ { "id": "STT4_YEAST", "url": "https://www.uniprot.org/uniprot/P37297", "type": "external" } ], "mass": 214607.0, "length": 1900, "protein_name": "Phosphatidylinositol 4-kinase STT4", "gene_name": "STT4", "organism": "Yeast", "refseq_name": "1-phosphatidylinositol 4-kinase STT4", "refseq_ac": [ { "id": "NP_013408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013408", "type": "external" } ], "gene_names_uniprotkb": "STT4; L2142.4", "gene_names_refseq": "STT4", "protein_names_uniprotkb": "Phosphatidylinositol 4-kinase STT4; 2.7.1.67; PI4-kinase; PtdIns-4-kinase", "protein_names_refseq": "1-phosphatidylinositol 4-kinase STT4", "tax_id": 559292, "disease": "chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); hereditary spastic paraplegia 84 (Disease Ontology:DOID:0112347)", "pathway": " (sce:YLR305C); (R-SCE-1483248); (R-SCE-1660514)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "14562106;14690591;18407956;19779198;23749301;24374639;32597660;33481703;33491328;8288577;9169871", "class_list": "", "function": "Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate. STT4 functions in PKC1 protein kinase pathway., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYU8", "ec_number_list": [ { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004430 1-phosphatidylinositol 4-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane", "go_biological_process": "GO:0016236 macroautophagy;GO:0030866 cortical actin cytoskeleton organization;GO:0048015 phosphatidylinositol-mediated signaling;GO:0000422 autophagy of mitochondrion;GO:0006995 cellular response to nitrogen starvation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P37297-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37298-1", "uniprot_id": [ { "id": "DHSD_YEAST", "url": "https://www.uniprot.org/uniprot/P37298", "type": "external" } ], "mass": 20249.0, "length": 181, "protein_name": "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial", "gene_name": "SDH4", "organism": "Yeast", "refseq_name": "succinate dehydrogenase membrane anchor subunit SDH4", "refseq_ac": [ { "id": "NP_010463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010463", "type": "external" } ], "gene_names_uniprotkb": "SDH4; ACN18; YD9395.11", "gene_names_refseq": "ACN18; SDH4", "protein_names_uniprotkb": "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; CybS; Succinate-ubiquinone reductase membrane anchor subunit", "protein_names_refseq": "succinate dehydrogenase membrane anchor subunit SDH4", "tax_id": 559292, "disease": "paraganglioma (Disease Ontology:DOID:0050773); mitochondrial complex II deficiency (Disease Ontology:DOID:0060537); pheochromocytoma/paraganglioma syndrome 1 (Disease Ontology:DOID:0061216); Carney-Stratakis syndrome (Disease Ontology:DOID:0080533); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)", "pathway": " (sce:YDR178W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11279023;11803020;14562106;14672929;14672930;17208193;17322287;21177495;24374639;8120006;9169867", "class_list": "", "function": "Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in system II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH3 and SDH4 form the membrane dimer that anchors the catalytic dimer formed by SDH1 and SDH2 to the matrix surface of the mitochondrial inner membrane. Electrons originating from the catalytic dimer enter the membrane dimer for ubiquinone reduction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSG0", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0048039 ubiquinone binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045273 respiratory chain complex II (succinate dehydrogenase)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006121 mitochondrial electron transport, succinate to ubiquinone;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P37298-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37303-1", "uniprot_id": [ { "id": "GLY1_YEAST", "url": "https://www.uniprot.org/uniprot/P37303", "type": "external" } ], "mass": 42815.0, "length": 387, "protein_name": "Low specificity L-threonine aldolase", "gene_name": "GLY1", "organism": "Yeast", "refseq_name": "threonine aldolase GLY1", "refseq_ac": [ { "id": "NP_010868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010868", "type": "external" } ], "gene_names_uniprotkb": "GLY1; SYGP-ORF34", "gene_names_refseq": "GLY1", "protein_names_uniprotkb": "Low specificity L-threonine aldolase; 4.1.2.48; Low specificity L-TA; TA", "protein_names_refseq": "threonine aldolase GLY1", "tax_id": 559292, "disease": "", "pathway": " (sce:YEL046C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "11875433;12872131;14557538;14562106;15665377;17330950;18407956;19684113;19779198;20702584;21126336;21177495;22106047;22218487;22814378;23749301;24374639;32597660;33481703;33491328;8132653;9151955;9163906;9169868", "class_list": "", "function": "Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLK4;P32615", "ec_number_list": [ { "id": "4.1.2.48", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.48", "type": "external" } ], "go_molecular_function": "GO:0008732 L-allo-threonine aldolase activity;GO:0004793 threonine aldolase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006545 glycine biosynthetic process;GO:0006567 L-threonine catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P37303-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37370-1", "uniprot_id": [ { "id": "VRP1_YEAST", "url": "https://www.uniprot.org/uniprot/P37370", "type": "external" } ], "mass": 82594.0, "length": 817, "protein_name": "Verprolin", "gene_name": "VRP1", "organism": "Yeast", "refseq_name": "Vrp1p", "refseq_ac": [ { "id": "NP_013441", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013441", "type": "external" } ], "gene_names_uniprotkb": "VRP1; END5; L8300.13; MDP2", "gene_names_refseq": "END5; MDP2; VRP1; YLR337W", "protein_names_uniprotkb": "Verprolin", "protein_names_refseq": "Vrp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR337C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "11875433;14562095;17563356;18407956;19756047;19779198;19795423;19823750;20702584;21126336;21177495;21725298;22218487;23749301;24374639;32597660;33229814;33481703;33491328;7968536;9169871", "class_list": "", "function": "Involved in cytoskeletal organization and cellular growth. May exert its effects on the cytoskeleton directly, or indirectly via proline-binding proteins (e.g. profilin) or proteins possessing SH3 domains., [UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 6, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 22, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 22, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 22, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 36, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 31, "binding_glycan_count": 0, "secondary_ac_list": "D6VYX7;Q06133", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0030479 actin cortical patch;GO:0000131 incipient cellular bud site;GO:0005935 cellular bud neck;GO:0043332 mating projection tip", "go_biological_process": "GO:0006897 endocytosis;GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0032465 regulation of cytokinesis;GO:0051666 actin cortical patch localization;GO:0007121 bipolar cellular bud site selection", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "P37370-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37838-1", "uniprot_id": [ { "id": "NOP4_YEAST", "url": "https://www.uniprot.org/uniprot/P37838", "type": "external" } ], "mass": 77825.0, "length": 685, "protein_name": "Nucleolar protein 4", "gene_name": "NOP4", "organism": "Yeast", "refseq_name": "mRNA-binding ribosome biosynthesis protein NOP4", "refseq_ac": [ { "id": "NP_015282", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_015282", "type": "external" } ], "gene_names_uniprotkb": "NOP4; NOP77", "gene_names_refseq": "NOP4; NOP77", "protein_names_uniprotkb": "Nucleolar protein 4; Nucleolar protein NOP77", "protein_names_refseq": "mRNA-binding ribosome biosynthesis protein NOP4", "tax_id": 559292, "disease": "alopecia, neurologic defects, and endocrinopathy syndrome (Disease Ontology:DOID:0112244)", "pathway": " (sce:YPL043W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14562106;15665377;17330950;18407956;19779198;20702584;21126336;21177495;23749301;24374639;32597660;33481703;33491328;8039505;8039506;9169875", "class_list": "", "function": "Required for 60S ribosomal subunit synthesis. Probably involved in the processing of 27S rRNA to produce mature 25S rRNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3X0", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0042802 identical protein binding;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P37838-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38009-1", "uniprot_id": [ { "id": "PUR92_YEAST", "url": "https://www.uniprot.org/uniprot/P38009", "type": "external" } ], "mass": 65263.0, "length": 592, "protein_name": "Bifunctional purine biosynthesis protein ADE17", "gene_name": "ADE17", "organism": "Yeast", "refseq_name": "bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17", "refseq_ac": [ { "id": "NP_013839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013839", "type": "external" } ], "gene_names_uniprotkb": "ADE17; YM8564.02C", "gene_names_refseq": "ADE17", "protein_names_uniprotkb": "Bifunctional purine biosynthesis protein ADE17; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR transformylase; ATIC; IMP synthase; Inosinicase", "protein_names_refseq": "bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17", "tax_id": 559292, "disease": "purine-pyrimidine metabolic disorder (Disease Ontology:DOID:653)", "pathway": " (sce:YMR120C); (R-SCE-73817)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10877846;14562106;18407956;19779198;22814378;23749301;24374639;33491328;7895733;9143321;9169872", "class_list": "", "function": "Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:10877846, PubMed:9143321). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10877846, PubMed:9143321). Also catalyzes the cyclization of FAICAR to IMP (PubMed:10877846, PubMed:9143321)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZU3", "ec_number_list": [ { "id": "2.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.3", "type": "external" }, { "id": "3.5.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.10", "type": "external" } ], "go_molecular_function": "GO:0003937 IMP cyclohydrolase activity;GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006164 purine nucleotide biosynthetic process;GO:0006189 'de novo' IMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38009-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38011-1", "uniprot_id": [ { "id": "GBLP_YEAST", "url": "https://www.uniprot.org/uniprot/P38011", "type": "external" } ], "mass": 34805.0, "length": 319, "protein_name": "Small ribosomal subunit protein RACK1", "gene_name": "ASC1", "organism": "Yeast", "refseq_name": "40S ribosomal protein RACK1 ASC1", "refseq_ac": [ { "id": "NP_013834", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013834", "type": "external" } ], "gene_names_uniprotkb": "ASC1; CPC2; YM9718.15C", "gene_names_refseq": "ASC1; ASU9; CPC2; NAD1", "protein_names_uniprotkb": "Small ribosomal subunit protein RACK1; Guanine nucleotide-binding protein subunit beta-like protein; RACK1; Receptor for activated C kinase; Receptor of activated protein kinase C 1", "protein_names_refseq": "40S ribosomal protein RACK1 ASC1", "tax_id": 559292, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (sce:YMR116C)", "pathway_count": 1, "publication_count": 31, "publication_id_list": "14562106;15012629;15334071;15340087;17287358;17563356;18407956;19779198;19795423;19823750;20702584;21109664;21126336;21704636;22096102;22106047;22218487;22814378;23749301;24374639;24524803;27821475;28223409;30465652;30516470;32597660;33481703;33491328;7895733;9038161;9169872", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). Located at the head of the 40S ribosomal subunit in the vicinity of the mRNA exit channel, RACK1 serves as a scaffold protein that can recruit other proteins to the ribosome. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation (PubMed:28223409, PubMed:30465652). Involved in the negative regulation of translation of a specific subset of proteins (PubMed:15340087)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZT9;Q6LAA5", "ec_number_list": [], "go_molecular_function": "GO:0005080 protein kinase C binding;GO:0001965 G-protein alpha-subunit binding;GO:0043022 ribosome binding;GO:0045182 translation regulator activity;GO:0005092 GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0070651 nonfunctional rRNA decay;GO:0007186 G protein-coupled receptor signaling pathway;GO:0010629 negative regulation of gene expression;GO:0017148 negative regulation of translation", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P38011-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38013-1", "uniprot_id": [ { "id": "AHP1_YEAST", "url": "https://www.uniprot.org/uniprot/P38013", "type": "external" } ], "mass": 19115.0, "length": 176, "protein_name": "Peroxiredoxin AHP1", "gene_name": "AHP1", "organism": "Yeast", "refseq_name": "thioredoxin peroxidase AHP1", "refseq_ac": [ { "id": "NP_013210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013210", "type": "external" } ], "gene_names_uniprotkb": "AHP1; L2916; L9354.5", "gene_names_refseq": "AHP1", "protein_names_uniprotkb": "Peroxiredoxin AHP1; 1.11.1.24; AHPC1; Alkyl hydroperoxide reductase; Cytoplasmic thiol peroxidase 3; Prx; TPx type II; TSA II; Thiol-specific antioxidant II; Thioredoxin peroxidase type II; Thioredoxin-dependent peroxiredoxin AHP1; cTPx 3", "protein_names_refseq": "thioredoxin peroxidase AHP1", "tax_id": 559292, "disease": "common cold (Disease Ontology:DOID:10459)", "pathway": " (sce:YLR109W)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10391912;10635552;10681558;14555475;14562106;14640681;15665377;17287358;18407956;19779198;19795423;19823750;20145245;21209336;22106047;22474296;23749301;24374639;32004955;32531362;33481703;33491328;36102610;7895733;9090053;9169871;9888818;9988687", "class_list": "", "function": "Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Preferentially eliminates organic peroxides rather than hydrogen peroxide (PubMed:10391912, PubMed:10681558, PubMed:9988687). Relays alkyl hydroperoxides as a signal to the transcription factor CAD1/YAP2 by inducing the formation of intramolecular disulfide bonds in CAD1, which causes its nuclear accumulation and activation (PubMed:20145245). Involved in cellular Mn(2+) homeostasis (PubMed:10635552)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYA9", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" } ], "go_molecular_function": "GO:0008379 thioredoxin peroxidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0045454 cell redox homeostasis;GO:0042744 hydrogen peroxide catabolic process;GO:0010038 response to metal ion", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P38013-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38041-1", "uniprot_id": [ { "id": "BOI1_YEAST", "url": "https://www.uniprot.org/uniprot/P38041", "type": "external" } ], "mass": 109295.0, "length": 980, "protein_name": "BEM1-interacting protein 1", "gene_name": "BOI1", "organism": "Yeast", "refseq_name": "Boi1p", "refseq_ac": [ { "id": "NP_009468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009468", "type": "external" } ], "gene_names_uniprotkb": "BOI1; BOB1; GIN7; YBL0717", "gene_names_refseq": "BOB1; BOI1; GIN7", "protein_names_uniprotkb": "BEM1-interacting protein 1; Growth inhibitory protein 7", "protein_names_refseq": "Boi1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL085W); (R-SCE-1660499)", "pathway_count": 2, "publication_count": 32, "publication_id_list": "12097146;14562106;15665377;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22218487;23749301;24374639;24909858;28265048;28270554;28904204;30516470;31208443;32597660;33229814;33481703;33491328;34965436;7502586;7813418;8666672", "class_list": "", "function": "Functions redundantly with BOI2 to promote the fusion of secretory vesicles with the plasma membrane at sites of polarized growth., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 108, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VPR9", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0055037 recycling endosome", "go_biological_process": "GO:0000920 septum digestion after cytokinesis;GO:0007015 actin filament organization;GO:0007032 endosome organization;GO:0001881 receptor recycling;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P38041-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38042-1", "uniprot_id": [ { "id": "CDC27_YEAST", "url": "https://www.uniprot.org/uniprot/P38042", "type": "external" } ], "mass": 85396.0, "length": 758, "protein_name": "Anaphase-promoting complex subunit CDC27", "gene_name": "CDC27", "organism": "Yeast", "refseq_name": "anaphase promoting complex subunit CDC27", "refseq_ac": [ { "id": "NP_009469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009469", "type": "external" } ], "gene_names_uniprotkb": "CDC27; APC3; SNB1; YBL0718", "gene_names_refseq": "APC3; CDC27; SNB1", "protein_names_uniprotkb": "Anaphase-promoting complex subunit CDC27; Anaphase-promoting complex subunit 3; Cell division control protein 27", "protein_names_refseq": "anaphase promoting complex subunit CDC27", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL084C); (R-SCE-983168)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10871279;14562095;14562106;15060174;1819514;18407956;19779198;21126336;23749301;24374639;32597660;33229814;33481703;33491328;7502586;7813418;7925276", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6VPS0", "ec_number_list": [], "go_molecular_function": "GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005680 anaphase-promoting complex;GO:0034399 nuclear periphery", "go_biological_process": "GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle;GO:0016567 protein ubiquitination;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0051445 regulation of meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P38042-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38063-1", "uniprot_id": [ { "id": "KPR4_YEAST", "url": "https://www.uniprot.org/uniprot/P38063", "type": "external" } ], "mass": 35720.0, "length": 326, "protein_name": "Ribose-phosphate pyrophosphokinase 4", "gene_name": "PRS4", "organism": "Yeast", "refseq_name": "ribose phosphate diphosphokinase subunit PRS4", "refseq_ac": [ { "id": "NP_009485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009485", "type": "external" } ], "gene_names_uniprotkb": "PRS4; PRPS4; YBL0619", "gene_names_refseq": "PRS4", "protein_names_uniprotkb": "Ribose-phosphate pyrophosphokinase 4; 2.7.6.1; Phosphoribosyl pyrophosphate synthase 4", "protein_names_refseq": "ribose phosphate diphosphokinase subunit PRS4", "tax_id": 559292, "disease": "Arts syndrome (Disease Ontology:DOID:0050647); Charcot-Marie-Tooth disease X-linked recessive 5 (Disease Ontology:DOID:0110210); phosphoribosylpyrophosphate synthetase superactivity (Disease Ontology:DOID:0111260); X-linked deafness 1 (Disease Ontology:DOID:0111739); retinitis pigmentosa (Disease Ontology:DOID:10584); gout (Disease Ontology:DOID:13189); fundus dystrophy (Disease Ontology:DOID:8501); diabetes insipidus (Disease Ontology:DOID:9409)", "pathway": " (sce:YBL068W); (R-SCE-73843)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10212224;12748633;14562095;14562106;15280369;24374639;33491328;7813418", "class_list": "", "function": "5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPT3;Q9HGQ6", "ec_number_list": [ { "id": "2.7.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.6.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0004749 ribose phosphate diphosphokinase activity", "go_cellular_component": "GO:0002189 ribose phosphate diphosphokinase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0009156 ribonucleoside monophosphate biosynthetic process;GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process;GO:0006164 purine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38063-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38069-1", "uniprot_id": [ { "id": "MNN2_YEAST", "url": "https://www.uniprot.org/uniprot/P38069", "type": "external" } ], "mass": 67774.0, "length": 597, "protein_name": "Alpha-1,2-mannosyltransferase MNN2", "gene_name": "MNN2", "organism": "Yeast", "refseq_name": "alpha-1,2-mannosyltransferase MNN2", "refseq_ac": [ { "id": "NP_009571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009571", "type": "external" } ], "gene_names_uniprotkb": "MNN2; CRV4; LDB8; TTP1; YBR0220", "gene_names_refseq": "CRV4; LDB8; MNN2; TTP1", "protein_names_uniprotkb": "Alpha-1,2-mannosyltransferase MNN2; 2.4.1.-; Calcium resistance and vanadate sensitivity protein 4; Mannan synthesis protein MNN2", "protein_names_refseq": "alpha-1,2-mannosyltransferase MNN2", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR015C)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "1097420;14562106;16107716;18410729;20236934;2082155;24374639;33491328;355255;381304;4124122;4578088;4578089;4612040;4612041;6802821;7813418;7992511;9413431;9756928", "class_list": "glycogene;glycosyltransferase", "function": "Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ17", "ec_number_list": [], "go_molecular_function": "GO:0000026 alpha-1,2-mannosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0046354 mannan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P38069-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000010001.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38070-1", "uniprot_id": [ { "id": "YPK3_YEAST", "url": "https://www.uniprot.org/uniprot/P38070", "type": "external" } ], "mass": 59591.0, "length": 525, "protein_name": "Serine/threonine-protein kinase YPK3", "gene_name": "YPK3", "organism": "Yeast", "refseq_name": "putative protein kinase YPK3", "refseq_ac": [ { "id": "NP_009584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009584", "type": "external" } ], "gene_names_uniprotkb": "YPK3; YBR0312", "gene_names_refseq": "YPK3", "protein_names_uniprotkb": "Serine/threonine-protein kinase YPK3; 2.7.11.1; Ribosomal S6 kinase homolog YPK3; S6K homolog YPK3", "protein_names_refseq": "putative protein kinase YPK3", "tax_id": 559292, "disease": "alcohol-related birth defects (Disease Ontology:DOID:0050668); non-syndromic X-linked intellectual disability 19 (Disease Ontology:DOID:0112019); intellectual disability (Disease Ontology:DOID:1059); primary biliary cholangitis (Disease Ontology:DOID:12236); dilated cardiomyopathy (Disease Ontology:DOID:12930); hyperinsulinism (Disease Ontology:DOID:2018); colon cancer (Disease Ontology:DOID:219); Coffin-Lowry syndrome (Disease Ontology:DOID:3783); myocardial infarction (Disease Ontology:DOID:5844); muscular atrophy (Disease Ontology:DOID:767); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YBR028C); (R-SCE-166208); (R-SCE-198693); (R-SCE-198753); (R-SCE-2559582); (R-SCE-444257); (R-SCE-881907); (R-SCE-9856649)", "pathway_count": 8, "publication_count": 20, "publication_id_list": "11062466;14562095;14562106;15665377;16172400;17330950;18407956;19779198;20702584;22218487;22814378;23749301;24374639;25767889;30516470;32597660;33481703;33491328;7813418;8091864", "class_list": "", "function": "AGC kinase which plays a role in TOR complex 1 (TORC1) signaling pathway which mediates temporal control of cell growth in response to nutrients (PubMed:11062466). Required for phosphorylation of ribosomal protein S6 (RPS6A/RPS6B) at 'Ser-232' and 'Ser-233' (PubMed:25767889)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ29", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0046777 protein autophosphorylation;GO:0018105 peptidyl-serine phosphorylation;GO:0038202 TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P38070-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38071-1", "uniprot_id": [ { "id": "ETR1_YEAST", "url": "https://www.uniprot.org/uniprot/P38071", "type": "external" } ], "mass": 42067.0, "length": 380, "protein_name": "Enoyl-[acyl-carrier-protein] reductase, mitochondrial", "gene_name": "ETR1", "organism": "Yeast", "refseq_name": "enoyl-[acyl-carrier-protein] reductase", "refseq_ac": [ { "id": "NP_009582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009582", "type": "external" } ], "gene_names_uniprotkb": "ETR1; MRF1'; MRF1; YBR0310", "gene_names_refseq": "ETR1; MRF1'; MRF1", "protein_names_uniprotkb": "Enoyl-[acyl-carrier-protein] reductase, mitochondrial; 1.3.1.104; 2-enoyl thioester reductase; Mitochondrial respiratory function protein 1", "protein_names_refseq": "enoyl-[acyl-carrier-protein] reductase", "tax_id": 559292, "disease": "childhood-onset dystonia with optic atrophy and basal ganglia abnormalities (Disease Ontology:DOID:0081419); Leber hereditary optic neuropathy with demyelinating disease of CNS (Disease Ontology:DOID:0111756); optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (sce:YBR026C); (R-SCE-77346)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11502169;11509667;12614607;14562106;14576278;17322287;18407956;23749301;24374639;26711224;33491328;7813418;8091864;8195160", "class_list": "", "function": "Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Required for respiration and the maintenance of the mitochondrial compartment., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ28;Q6Q5P2", "ec_number_list": [ { "id": "1.3.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.104", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0141148 enoyl-[acyl-carrier-protein] reductase (NADPH) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P38071-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38075-1", "uniprot_id": [ { "id": "PDX3_YEAST", "url": "https://www.uniprot.org/uniprot/P38075", "type": "external" } ], "mass": 26908.0, "length": 228, "protein_name": "Pyridoxamine 5'-phosphate oxidase", "gene_name": "PDX3", "organism": "Yeast", "refseq_name": "pyridoxamine-phosphate oxidase PDX3", "refseq_ac": [ { "id": "NP_009591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009591", "type": "external" } ], "gene_names_uniprotkb": "PDX3; YBR0321", "gene_names_refseq": "PDX3", "protein_names_uniprotkb": "Pyridoxamine 5'-phosphate oxidase; 1.4.3.5; PNP/PMP oxidase; PNPOx", "protein_names_refseq": "pyridoxamine-phosphate oxidase PDX3", "tax_id": 559292, "disease": "pyridoxamine 5'-phosphate oxidase deficiency (Disease Ontology:DOID:0111329); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (sce:YBR035C); (R-SCE-964975)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12872131;17322287;22984289;23749301;24374639;33491328;7813418;7896706;8091864", "class_list": "", "function": "Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ35", "ec_number_list": [ { "id": "1.4.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.5", "type": "external" } ], "go_molecular_function": "GO:0010181 FMN binding;GO:0004733 pyridoxamine phosphate oxidase activity", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0008615 pyridoxine biosynthetic process;GO:0009443 pyridoxal 5'-phosphate salvage", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38075-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38077-1", "uniprot_id": [ { "id": "ATPG_YEAST", "url": "https://www.uniprot.org/uniprot/P38077", "type": "external" } ], "mass": 34351.0, "length": 311, "protein_name": "ATP synthase subunit gamma, mitochondrial", "gene_name": "ATP3", "organism": "Yeast", "refseq_name": "F1F0 ATP synthase subunit gamma", "refseq_ac": [ { "id": "NP_009595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009595", "type": "external" } ], "gene_names_uniprotkb": "ATP3; ATP3a; ATP3b; YBR0408", "gene_names_refseq": "ATP3", "protein_names_uniprotkb": "ATP synthase subunit gamma, mitochondrial; F-ATPase gamma subunit", "protein_names_refseq": "F1F0 ATP synthase subunit gamma", "tax_id": 559292, "disease": "schizophrenia (Disease Ontology:DOID:5419); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YBR039W); (R-SCE-9837999)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10576729;12898710;14562106;17082766;17322287;19233840;24374639;24909858;32597660;33491328;7498726;7813418;7929329", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ39;Q54AF5;Q76MT6", "ec_number_list": [], "go_molecular_function": "GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P38077-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38080-1", "uniprot_id": [ { "id": "AKL1_YEAST", "url": "https://www.uniprot.org/uniprot/P38080", "type": "external" } ], "mass": 123989.0, "length": 1108, "protein_name": "Serine/threonine-protein kinase AKL1", "gene_name": "AKL1", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase AKL1", "refseq_ac": [ { "id": "NP_009615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009615", "type": "external" } ], "gene_names_uniprotkb": "AKL1; YBR0519", "gene_names_refseq": "AKL1", "protein_names_uniprotkb": "Serine/threonine-protein kinase AKL1; 2.7.11.1", "protein_names_refseq": "serine/threonine protein kinase AKL1", "tax_id": 559292, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (sce:YBR059C)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "11875433;12872131;12956961;14562106;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22218487;22814378;23749301;24374639;24909858;28069741;29895620;30516470;32597660;33229814;33481703;33491328;34965436;7813418", "class_list": "", "function": "Phosphorylates SCD5., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 15, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 15, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 15, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 81, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ59", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0071944 cell periphery;GO:0005628 prospore membrane;GO:0005935 cellular bud neck", "go_biological_process": "GO:0007015 actin filament organization;GO:0000147 actin cortical patch assembly;GO:1900186 negative regulation of clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "P38080-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38084-1", "uniprot_id": [ { "id": "BAP2_YEAST", "url": "https://www.uniprot.org/uniprot/P38084", "type": "external" } ], "mass": 67769.0, "length": 609, "protein_name": "Leu/Val/Ile amino-acid permease", "gene_name": "BAP2", "organism": "Yeast", "refseq_name": "branched-chain amino acid permease BAP2", "refseq_ac": [ { "id": "NP_009624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009624", "type": "external" } ], "gene_names_uniprotkb": "BAP2; YBR0629", "gene_names_refseq": "BAP2", "protein_names_uniprotkb": "Leu/Val/Ile amino-acid permease; Branched-chain amino-acid permease 2", "protein_names_refseq": "branched-chain amino acid permease BAP2", "tax_id": 559292, "disease": "retinitis pigmentosa 68 (Disease Ontology:DOID:0110374); sensorineural hearing loss (Disease Ontology:DOID:10003); blindness (Disease Ontology:DOID:1432)", "pathway": " (sce:YBR068C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10467005;10654085;14562095;14562106;16847258;17330950;17563356;18407956;19779198;19795423;19823750;20702584;22218487;23749301;24374639;24909858;32597660;33481703;33491328;34965436;7495881;7813418", "class_list": "", "function": "Permease for leucine, valine and isoleucine. Also transports cysteine, methionine, phenyalanine, tyrosine and tryptophan., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ67", "ec_number_list": [], "go_molecular_function": "GO:0015171 amino acid transmembrane transporter activity;GO:0015192 L-phenylalanine transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:1903801 L-leucine import across plasma membrane;GO:0055085 transmembrane transport;GO:0006865 amino acid transport;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P38084-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38085-1", "uniprot_id": [ { "id": "TAT1_YEAST", "url": "https://www.uniprot.org/uniprot/P38085", "type": "external" } ], "mass": 68758.0, "length": 619, "protein_name": "Valine/tyrosine/tryptophan amino-acid permease 1", "gene_name": "TAT1", "organism": "Yeast", "refseq_name": "amino acid transporter TAT1", "refseq_ac": [ { "id": "NP_009625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009625", "type": "external" } ], "gene_names_uniprotkb": "TAT1; TAP1; VAP1; YBR0710", "gene_names_refseq": "TAP1; TAT1; VAP1", "protein_names_uniprotkb": "Valine/tyrosine/tryptophan amino-acid permease 1; Tyrosine and tryptophan amino acid transporter 1", "protein_names_refseq": "amino acid transporter TAT1", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR069C)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10467005;11875433;14557538;14562106;15665377;16847258;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21177495;22106047;22218487;23749301;24374639;30516470;32597660;33481703;33491328;7523855;7813418;7985423", "class_list": "", "function": "High-affinity transport of valine and tyrosine. Low-affinity transport of tryptophan. Can also transport L-cysteine., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ68", "ec_number_list": [], "go_molecular_function": "GO:0015171 amino acid transmembrane transporter activity;GO:0022893 low-affinity tryptophan transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006865 amino acid transport;GO:0015827 tryptophan transport;GO:0003333 amino acid transmembrane transport;GO:0015828 tyrosine transport", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P38085-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38086-1", "uniprot_id": [ { "id": "RDH54_YEAST", "url": "https://www.uniprot.org/uniprot/P38086", "type": "external" } ], "mass": 107946.0, "length": 958, "protein_name": "DNA repair and recombination protein RDH54", "gene_name": "RDH54", "organism": "Yeast", "refseq_name": "DNA-dependent ATPase RDH54", "refseq_ac": [ { "id": "NP_009629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009629", "type": "external" } ], "gene_names_uniprotkb": "RDH54; TID1; YBR0715", "gene_names_refseq": "RDH54; TID1", "protein_names_uniprotkb": "DNA repair and recombination protein RDH54; 3.6.4.-; RAD homolog 54; Recombination factor TID1; Two hybrid interaction with DMC1 protein 1", "protein_names_refseq": "DNA-dependent ATPase RDH54", "tax_id": 559292, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YBR073W)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10970884;11005857;11470411;12702674;12748633;12775844;14562095;14562106;18407956;19779198;19917248;21126336;22106047;23749301;24374639;32597660;33481703;33491328;7813418;7985423;9335591;9409819;9409820", "class_list": "", "function": "Involved in the recombinational repair of double-strand breaks (DSB) in DNA during mitosis and meiosis. Has DNA dependent ATPase activity. Promotes D-loop (displacement loop) formation with RAD51 recombinase. Modifies the topology of double-stranded DNA during the D-loop reaction to facilitate the invasion of the homologous duplex molecule by the initiating single-stranded DNA substrate. Required for adaptation from G2/M checkpoint arrest induced by a double strand break, by participating in monitoring the extent of single-stranded DNA produced by resection of DNA ends. This role is distinct from its roles in recombination. Promotes colocalization of RAD51 and DMC1 during meiotic recombination. Involved in crossover interference., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ73", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003690 double-stranded DNA binding;GO:0003678 DNA helicase activity;GO:0008094 ATP-dependent activity, acting on DNA", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0000724 double-strand break repair via homologous recombination;GO:0007131 reciprocal meiotic recombination;GO:0032392 DNA geometric change", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P38086-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38088-1", "uniprot_id": [ { "id": "SYG_YEAST", "url": "https://www.uniprot.org/uniprot/P38088", "type": "external" } ], "mass": 78184.0, "length": 690, "protein_name": "Glycine--tRNA ligase 1, mitochondrial", "gene_name": "GRS1", "organism": "Yeast", "refseq_name": "glycine--tRNA ligase", "refseq_ac": [ { "id": "NP_009679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009679", "type": "external" } ], "gene_names_uniprotkb": "GRS1; YBR0917", "gene_names_refseq": "GRS1", "protein_names_uniprotkb": "Glycine--tRNA ligase 1, mitochondrial; 2.7.7.-; 6.1.1.14; Ap4A synthetase; Diadenosine tetraphosphate synthetase; GlyRS 1; GlyRS1; Glycyl-tRNA synthetase 1", "protein_names_refseq": "glycine--tRNA ligase", "tax_id": 559292, "disease": "Charcot-Marie-Tooth disease type 2 (Disease Ontology:DOID:0050539); Charcot-Marie-Tooth disease type 2D (Disease Ontology:DOID:0110164); autosomal dominant distal hereditary motor neuronopathy 5 (Disease Ontology:DOID:0111203); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); spinal muscular atrophy (Disease Ontology:DOID:12377)", "pathway": " (sce:YBR121C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10874035;14562106;14690591;14734560;15665377;17330950;18407956;19779198;22814378;23816885;24374639;33481703;33491328;7813418;7900426", "class_list": "", "function": "Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:23816885). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQB9", "ec_number_list": [ { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.1.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.14", "type": "external" } ], "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0005524 ATP binding;GO:0046983 protein dimerization activity;GO:0004820 glycine-tRNA ligase activity;GO:0141192 ATP:ATP adenylyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0015966 diadenosine tetraphosphate biosynthetic process;GO:0006353 DNA-templated transcription termination;GO:0070150 mitochondrial glycyl-tRNA aminoacylation;GO:0006426 glycyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P38088-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38090-1", "uniprot_id": [ { "id": "AGP2_YEAST", "url": "https://www.uniprot.org/uniprot/P38090", "type": "external" } ], "mass": 67262.0, "length": 596, "protein_name": "General amino acid permease AGP2", "gene_name": "AGP2", "organism": "Yeast", "refseq_name": "Agp2p", "refseq_ac": [ { "id": "NP_009690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009690", "type": "external" } ], "gene_names_uniprotkb": "AGP2; YBR1007", "gene_names_refseq": "AGP2", "protein_names_uniprotkb": "General amino acid permease AGP2", "protein_names_refseq": "Agp2p", "tax_id": 559292, "disease": "retinitis pigmentosa 68 (Disease Ontology:DOID:0110374)", "pathway": " (sce:YBR132C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10545096;12132580;16847258;19779198;24374639;33491328;7813418;7954890;8091856", "class_list": "", "function": "General amino acid permease with broad substrate specificity. Can also transport carnitine., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQC9", "ec_number_list": [], "go_molecular_function": "GO:0015171 amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0003333 amino acid transmembrane transport;GO:1902269 positive regulation of polyamine transmembrane transport;GO:1902274 positive regulation of (R)-carnitine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38090-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38109-1", "uniprot_id": [ { "id": "ATG42_YEAST", "url": "https://www.uniprot.org/uniprot/P38109", "type": "external" } ], "mass": 57639.0, "length": 508, "protein_name": "Vacuolar serine-type carboxypeptidase ATG42", "gene_name": "ATG42", "organism": "Yeast", "refseq_name": "carboxypeptidase C", "refseq_ac": [ { "id": "NP_009697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009697", "type": "external" } ], "gene_names_uniprotkb": "ATG42; YBR1015", "gene_names_refseq": "ATG42", "protein_names_uniprotkb": "Vacuolar serine-type carboxypeptidase ATG42; 3.4.16.5; CPC; Carboxypeptidase C", "protein_names_refseq": "carboxypeptidase C", "tax_id": 559292, "disease": "brain small vessel disease 6 with leukoencephalopathy (Disease Ontology:DOID:0061236); galactosialidosis (Disease Ontology:DOID:0080540); lysosomal storage disease (Disease Ontology:DOID:3211)", "pathway": " (sce:YBR139W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562106;16879428;17322287;17408619;19897216;24374639;29514932;7813418;7954890;8091856", "class_list": "", "function": "Vacuolar serine-type carboxypeptidase involved in vacuolar zymogen activation, breakdown of the autophagic body, and autophagosome-dependent protein synthesis (PubMed:29514932). Plays a key role in phytochelatin (PC) synthesis from glutathione (GSH) by cleaving the Gly from GSH and form the PC-peptides of the structure (gamma-Glu-Cys)2-Gly (PubMed:17408619). Also involved in resistance to xenobiotics via the degradation of glutathione-S-conjugates (PubMed:19897216)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VQD5", "ec_number_list": [], "go_molecular_function": "GO:0017171 serine hydrolase activity;GO:0004185 serine-type carboxypeptidase activity", "go_cellular_component": "GO:0005775 vacuolar lumen;GO:0000324 fungal-type vacuole;GO:0000328 fungal-type vacuole lumen", "go_biological_process": "GO:0016236 macroautophagy;GO:0006995 cellular response to nitrogen starvation;GO:0031638 zymogen activation;GO:0046938 phytochelatin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38109-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38110-1", "uniprot_id": [ { "id": "ATM_YEAST", "url": "https://www.uniprot.org/uniprot/P38110", "type": "external" } ], "mass": 321524.0, "length": 2787, "protein_name": "Serine/threonine-protein kinase TEL1", "gene_name": "TEL1", "organism": "Yeast", "refseq_name": "DNA-binding protein kinase TEL1", "refseq_ac": [ { "id": "NP_009465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009465", "type": "external" } ], "gene_names_uniprotkb": "TEL1; YBL0706", "gene_names_refseq": "TEL1", "protein_names_uniprotkb": "Serine/threonine-protein kinase TEL1; 2.7.11.1; ATM homolog; DNA-damage checkpoint kinase TEL1; Telomere length regulation protein 1", "protein_names_refseq": "DNA-binding protein kinase TEL1", "tax_id": 559292, "disease": "female breast cancer (Disease Ontology:DOID:0050671); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); lymphoma (Disease Ontology:DOID:0060058); pre-malignant neoplasm (Disease Ontology:DOID:0060071); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); leukemia (Disease Ontology:DOID:1240); ataxia telangiectasia (Disease Ontology:DOID:12704); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); disease of cellular proliferation (Disease Ontology:DOID:14566); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969); infertility (Disease Ontology:DOID:5223); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); lung small cell carcinoma (Disease Ontology:DOID:5409); prostate carcinoma in situ (Disease Ontology:DOID:8634); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease Ontology:DOID:9669)", "pathway": " (sce:YBL088C); (R-SCE-2559586); (R-SCE-5693548); (R-SCE-5693565); (R-SCE-9664873)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "11095737;11239397;11430828;11544181;11707419;11983176;12792653;12923051;15369670;15458641;15975089;16228207;21177495;24374639;33491328;7502586;7671310;7813418;8553072", "class_list": "", "function": "Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited by the MRX-complex to sites of DNA lesions immediately after damage to initiate non-homologous end-joining (NHEJ). Subsequently displaced by the RPA complex in a reaction probably involving the SAE2 protein. Phosphorylates MRE11 and XRS2, 2 subunits of the MRX-complex. The phosphorylation of MRE11 is a feedback response from the checkpoint signaling pathway. Phosphorylates RAD9, CHK1 and RAD53, leading to the activation of the CHK1 and RAD23 kinases involved in the DNA damage response cascade. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Also phosphorylates SLX4 and RTT107 which are involved in genome stability. Required for the control of telomere length and genome stability., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPR6", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042162 telomeric DNA binding;GO:0070273 phosphatidylinositol-4-phosphate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005694 chromosome;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006281 DNA repair;GO:0000723 telomere maintenance;GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0042770 signal transduction in response to DNA damage", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P38110-1", "record_type": "protein", "filter_code": "0000000.0100111.001000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38111-1", "uniprot_id": [ { "id": "ATR_YEAST", "url": "https://www.uniprot.org/uniprot/P38111", "type": "external" } ], "mass": 273342.0, "length": 2368, "protein_name": "Serine/threonine-protein kinase MEC1", "gene_name": "MEC1", "organism": "Yeast", "refseq_name": "protein kinase MEC1", "refseq_ac": [ { "id": "NP_009694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009694", "type": "external" } ], "gene_names_uniprotkb": "MEC1; ESR1; SAD3; YBR1012", "gene_names_refseq": "ESR1; MEC1; RAD31; SAD3", "protein_names_uniprotkb": "Serine/threonine-protein kinase MEC1; 2.7.11.1; ATR homolog; DNA-damage checkpoint kinase MEC1; Mitosis entry checkpoint protein 1", "protein_names_refseq": "protein kinase MEC1", "tax_id": 559292, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); Seckel syndrome 1 (Disease Ontology:DOID:0070007); adenoid cystic carcinoma (Disease Ontology:DOID:0080202); Alzheimer's disease (Disease Ontology:DOID:10652); ataxia telangiectasia (Disease Ontology:DOID:12704); lung cancer (Disease Ontology:DOID:1324); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (sce:YBR136W); (R-SCE-2559586); (R-SCE-5693548); (R-SCE-5693565); (R-SCE-9664873)", "pathway_count": 5, "publication_count": 33, "publication_id_list": "10950868;11060031;11095737;11140636;11359899;12181334;12792653;14595109;14988729;15369670;15458641;15975089;16148046;16365046;17563356;18407956;19779198;20061370;20190278;22031224;23749301;24374639;31340146;32597660;33481703;33491328;34569643;7813418;7926756;8065923;8091856;8553072;8986766", "class_list": "", "function": "Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited in complex with protein LCD1 by the single-strand-binding protein complex RPA to DNA lesions in order to initiate the DNA repair by homologous recombination, after the MRX-complex and TEL1 are displaced. Phosphorylates LCD1 and RPA2, a subunit of RPA, involved in DNA replication, repair and recombination. Phosphorylates RAD9, CHK1 and RAD53, which leads to the activation of the CHK1 and RAD53 kinases involved in DNA damage repair cascade. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Also phosphorylates SLX4 and RTT107 which are proteins involved in genome stability. Required for cell growth and meiotic recombination., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQD2;Q02580", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005694 chromosome", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0000723 telomere maintenance;GO:0006260 DNA replication;GO:0042770 signal transduction in response to DNA damage", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P38111-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38112-1", "uniprot_id": [ { "id": "MAK5_YEAST", "url": "https://www.uniprot.org/uniprot/P38112", "type": "external" } ], "mass": 87048.0, "length": 773, "protein_name": "ATP-dependent RNA helicase MAK5", "gene_name": "MAK5", "organism": "Yeast", "refseq_name": "ATP-dependent RNA helicase", "refseq_ac": [ { "id": "NP_009700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009700", "type": "external" } ], "gene_names_uniprotkb": "MAK5; YBR1119", "gene_names_refseq": "MAK5", "protein_names_uniprotkb": "ATP-dependent RNA helicase MAK5; 3.6.4.13; Maintenance of killer protein 5", "protein_names_refseq": "ATP-dependent RNA helicase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR142W)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "13680366;14562095;14562106;17330950;17563356;18407956;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33481703;33491328;7754712;7813418;787537", "class_list": "", "function": "ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs. Required for the maintenance of dsRNA killer plasmid., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQD8", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P38112-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38115-1", "uniprot_id": [ { "id": "ARA1_YEAST", "url": "https://www.uniprot.org/uniprot/P38115", "type": "external" } ], "mass": 38884.0, "length": 344, "protein_name": "D-arabinose dehydrogenase [NAD(P)+] heavy chain", "gene_name": "ARA1", "organism": "Yeast", "refseq_name": "D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1", "refseq_ac": [ { "id": "NP_009707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009707", "type": "external" } ], "gene_names_uniprotkb": "ARA1; YBR1127", "gene_names_refseq": "ARA1", "protein_names_uniprotkb": "D-arabinose dehydrogenase [NAD(P)+] heavy chain; 1.1.1.117; AKR3C", "protein_names_refseq": "D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1", "tax_id": 559292, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); polycystic ovary syndrome (Disease Ontology:DOID:11612); allergic disease (Disease Ontology:DOID:1205); hyperglycemia (Disease Ontology:DOID:4195); hypokalemia (Disease Ontology:DOID:4500); hepatocellular carcinoma (Disease Ontology:DOID:684); cataract (Disease Ontology:DOID:83); diabetic retinopathy (Disease Ontology:DOID:8947); diabetic neuropathy (Disease Ontology:DOID:9743); galactosemia (Disease Ontology:DOID:9870)", "pathway": " (sce:YBR149W); (R-SCE-193144); (R-SCE-193368); (R-SCE-193775); (R-SCE-193807); (R-SCE-196108); (R-SCE-2162123); (R-SCE-5365859); (R-SCE-5652227); (R-SCE-70221); (R-SCE-9757110)", "pathway_count": 11, "publication_count": 12, "publication_id_list": "14562106;17330950;18407956;19779198;2005616;21126336;23749301;24374639;33481703;33491328;7813418;9920381", "class_list": "", "function": "Catalyzes the oxidation of D-arabinose, L-xylose, L-fucose and L-galactose in the presence of NADP(+)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQE4", "ec_number_list": [ { "id": "1.1.1.156", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.156", "type": "external" }, { "id": "1.1.1.117", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.117", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.116", "type": "external" }, { "id": "1.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.-", "type": "external" }, { "id": "1.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.2", "type": "external" } ], "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0045290 D-arabinose 1-dehydrogenase [NAD(P)+] activity;GO:0047816 D-arabinose 1-dehydrogenase (NAD+) activity;GO:0106271 D-arabinose 1-dehydrogenase (NADP+) activity;GO:0052588 diacetyl reductase ((S)-acetoin forming) (NAD+) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0045149 acetoin metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38115-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38116-1", "uniprot_id": [ { "id": "ARL1_YEAST", "url": "https://www.uniprot.org/uniprot/P38116", "type": "external" } ], "mass": 20434.0, "length": 183, "protein_name": "ADP-ribosylation factor-like protein 1", "gene_name": "ARL1", "organism": "Yeast", "refseq_name": "Arf family GTPase ARL1", "refseq_ac": [ { "id": "NP_009723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009723", "type": "external" } ], "gene_names_uniprotkb": "ARL1; ARF3; YBR1216", "gene_names_refseq": "ARL1; DLP2", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 1; Arf-like GTPase 1", "protein_names_refseq": "Arf family GTPase ARL1", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR164C); (R-SCE-6811440)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11535602;12052896;12620188;12620189;14562106;24374639;28404745;33491328;7813418;9388248", "class_list": "", "function": "Recruits golgins such as IMH1 to the Golgi. Can bind and hydrolyze GTP. May be involved in trafficking events within the endosomal system., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQG0", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005802 trans-Golgi network;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0016236 macroautophagy;GO:0034605 cellular response to heat;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38116-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38128-1", "uniprot_id": [ { "id": "SMP1_YEAST", "url": "https://www.uniprot.org/uniprot/P38128", "type": "external" } ], "mass": 49414.0, "length": 452, "protein_name": "Transcription factor SMP1", "gene_name": "SMP1", "organism": "Yeast", "refseq_name": "Smp1p", "refseq_ac": [ { "id": "NP_009741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009741", "type": "external" } ], "gene_names_uniprotkb": "SMP1; YBR1245", "gene_names_refseq": "SMP1", "protein_names_uniprotkb": "Transcription factor SMP1", "protein_names_refseq": "Smp1p", "tax_id": 559292, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language (Disease Ontology:DOID:0070050); intellectual disability (Disease Ontology:DOID:1059); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); status epilepticus (Disease Ontology:DOID:1824); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (sce:YBR182C); (R-SCE-525793)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12482976;17322287;21177495;24374639;33481703;33491328;7813418;7871891;9121433", "class_list": "", "function": "Transcription factor that controls part of the HOG1-mediated osmostress responses. Binds to the DNA sequence 5'-ACTACTA[TA](4)TAG-3'. Does not appear to function in the MPK1 pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQH6", "ec_number_list": [], "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071470 cellular response to osmotic stress", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38128-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38130-1", "uniprot_id": [ { "id": "KTR3_YEAST", "url": "https://www.uniprot.org/uniprot/P38130", "type": "external" } ], "mass": 47482.0, "length": 404, "protein_name": "Probable mannosyltransferase KTR3", "gene_name": "KTR3", "organism": "Yeast", "refseq_name": "mannosyltransferase KTR3", "refseq_ac": [ { "id": "NP_009764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009764", "type": "external" } ], "gene_names_uniprotkb": "KTR3; YBR1445", "gene_names_refseq": "KTR3", "protein_names_uniprotkb": "Probable mannosyltransferase KTR3; 2.4.1.-", "protein_names_refseq": "mannosyltransferase KTR3", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR205W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;16107716;17322287;24374639;33481703;7813418;8368014", "class_list": "glycogene;glycosyltransferase", "function": "Possible glycosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQK3;E9P931", "ec_number_list": [], "go_molecular_function": "GO:0000026 alpha-1,2-mannosyltransferase activity;GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0000032 cell wall mannoprotein biosynthetic process;GO:0006493 protein O-linked glycosylation;GO:0006487 protein N-linked glycosylation;GO:0006491 N-glycan processing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38130-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38137-1", "uniprot_id": [ { "id": "FAT2_YEAST", "url": "https://www.uniprot.org/uniprot/P38137", "type": "external" } ], "mass": 60489.0, "length": 543, "protein_name": "Oxalate--CoA ligase", "gene_name": "PCS60", "organism": "Yeast", "refseq_name": "Pcs60p", "refseq_ac": [ { "id": "NP_009781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009781", "type": "external" } ], "gene_names_uniprotkb": "PCS60; AAE3; FAT2; YBR1512", "gene_names_refseq": "FAT2; PCS60", "protein_names_uniprotkb": "Oxalate--CoA ligase; 6.2.1.8; Acyl-activating enzyme 3; Oxalyl-CoA synthetase; Peroxisomal-coenzyme A synthetase", "protein_names_refseq": "Pcs60p", "tax_id": 559292, "disease": "combined malonic and methylmalonic acidemia (Disease Ontology:DOID:0111263)", "pathway": " (sce:YBR222C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;24291261;24374639;26359497;7813418;8841414", "class_list": "", "function": "Catalyzes the first step in a degradation pathway of oxalate to CO(2) to protect the cell against the harmful effects of oxalate derived from endogenous processes or an environmental sources., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQL9", "ec_number_list": [ { "id": "6.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0031956 medium-chain fatty acid-CoA ligase activity;GO:0050203 oxalate-CoA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005778 peroxisomal membrane;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0033611 oxalate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P38137-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38138-1", "uniprot_id": [ { "id": "GLU2A_YEAST", "url": "https://www.uniprot.org/uniprot/P38138", "type": "external" } ], "mass": 110266.0, "length": 954, "protein_name": "Glucosidase 2 subunit alpha", "gene_name": "ROT2", "organism": "Yeast", "refseq_name": "glucan 1,3-alpha-glucosidase ROT2", "refseq_ac": [ { "id": "NP_009788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009788", "type": "external" } ], "gene_names_uniprotkb": "ROT2; GLS2; YBR1526", "gene_names_refseq": "GLS2; ROT2", "protein_names_uniprotkb": "Glucosidase 2 subunit alpha; 3.2.1.207; Alpha-glucosidase II subunit alpha; Glucosidase II subunit alpha; Reversal of TOR2 lethality protein 2", "protein_names_refseq": "glucan 1,3-alpha-glucosidase ROT2", "tax_id": 559292, "disease": "polycystic liver disease (Disease Ontology:DOID:0050770); polycystic kidney disease (Disease Ontology:DOID:0080322); polycystic kidney disease 3 (Disease Ontology:DOID:0110860)", "pathway": " (sce:YBR229C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;16373354;24374639;33481703;6216253;7813418;8910335", "class_list": "glycogene;glycosylhydrolase", "function": "Catalytic subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 11, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.207", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.207", "type": "external" } ], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0033919 glucan 1,3-alpha-glucosidase activity;GO:0090599 alpha-glucosidase activity;GO:0106407 Glc2Man9GlcNAc2 oligosaccharide glucosidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0017177 glucosidase II complex", "go_biological_process": "GO:0000271 polysaccharide biosynthetic process;GO:0006491 N-glycan processing;GO:0070880 fungal-type cell wall beta-glucan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38138-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000011001.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38139-1", "uniprot_id": [ { "id": "LDH1_YEAST", "url": "https://www.uniprot.org/uniprot/P38139", "type": "external" } ], "mass": 43287.0, "length": 375, "protein_name": "Lipid droplet hydrolase 1", "gene_name": "LDH1", "organism": "Yeast", "refseq_name": "triacylglycerol lipase", "refseq_ac": [ { "id": "NP_009763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009763", "type": "external" } ], "gene_names_uniprotkb": "LDH1; YBR1444", "gene_names_refseq": "LDH1", "protein_names_uniprotkb": "Lipid droplet hydrolase 1; 3.1.1.3; Lipid esterase; Triacylglycerol lipase", "protein_names_refseq": "triacylglycerol lipase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR204C); (R-SCE-426048)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14645503;21478430;21478434;24374639;33491328;7813418;8368014", "class_list": "", "function": "Serine hydrolase required for the maintenance of steady state level of non-polar and polar lipids of lipid droplets and thus plays a role in maintaining the lipids homeostasis (PubMed:21478434). Exhibits both esterase and triacylglycerol lipase activity (PubMed:21478434)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQK2", "ec_number_list": [ { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.1.1.101", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.101", "type": "external" } ], "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds;GO:0047372 monoacylglycerol lipase activity;GO:0017171 serine hydrolase activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0016020 membrane", "go_biological_process": "GO:0055088 lipid homeostasis;GO:0046464 acylglycerol catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38139-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38140-1", "uniprot_id": [ { "id": "ERT1_YEAST", "url": "https://www.uniprot.org/uniprot/P38140", "type": "external" } ], "mass": 60311.0, "length": 529, "protein_name": "Transcription activator of gluconeogenesis ERT1", "gene_name": "ERT1", "organism": "Yeast", "refseq_name": "Ert1p", "refseq_ac": [ { "id": "NP_009798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009798", "type": "external" } ], "gene_names_uniprotkb": "ERT1; YBR1622", "gene_names_refseq": "ERT1", "protein_names_uniprotkb": "Transcription activator of gluconeogenesis ERT1; Ethanol regulator of translation 1", "protein_names_refseq": "Ert1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR239C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;18202368;18419300;19686338;23749301;24374639;33491328;7813418", "class_list": "", "function": "Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes like PCK1. Involved in restriction of Ty1 transposition., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQN5", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006094 gluconeogenesis;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38140-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38143-1", "uniprot_id": [ { "id": "GPX2_YEAST", "url": "https://www.uniprot.org/uniprot/P38143", "type": "external" } ], "mass": 18406.0, "length": 162, "protein_name": "Glutathione peroxidase-like peroxiredoxin 2", "gene_name": "GPX2", "organism": "Yeast", "refseq_name": "glutathione peroxidase GPX2", "refseq_ac": [ { "id": "NP_009803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009803", "type": "external" } ], "gene_names_uniprotkb": "GPX2; YBR1632", "gene_names_refseq": "AMI1; GPX2", "protein_names_uniprotkb": "Glutathione peroxidase-like peroxiredoxin 2; 1.11.1.24; GPx 2; Glutathione peroxidase homolog 2", "protein_names_refseq": "glutathione peroxidase GPX2", "tax_id": 559292, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); spondylometaphyseal dysplasia Sedaghatian type (Disease Ontology:DOID:0112298); pre-eclampsia (Disease Ontology:DOID:10591); nephrotic syndrome (Disease Ontology:DOID:1184); colon cancer (Disease Ontology:DOID:219); acute kidney failure (Disease Ontology:DOID:3021); gastric adenocarcinoma (Disease Ontology:DOID:3717); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YBR244W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10480913;11445588;14562095;14562106;16251189;17322287;17563356;18407956;21763276;24374639;33491328;7813418", "class_list": "", "function": "Glutathione peroxidase-like protein that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress (PubMed:10480913, PubMed:11445588). Plays an important role in the oxidative stress-induced response in the presence of Ca(2+). Has peroxidase activity using preferentially thioredoxin as a reducing power. The redox state of the mitochondrial GPX2 is regulated by TRX1 and TRX2 (cytoplasmic thioredoxin), and by TRX3 (mitochondrial matrix thioredoxin) (PubMed:16251189). Involved in sporulation (PubMed:21763276)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQP0", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" } ], "go_molecular_function": "GO:0004602 glutathione peroxidase activity;GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity;GO:0140824 thioredoxin-dependent peroxiredoxin activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38143-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38144-1", "uniprot_id": [ { "id": "ISW1_YEAST", "url": "https://www.uniprot.org/uniprot/P38144", "type": "external" } ], "mass": 131102.0, "length": 1129, "protein_name": "ISWI chromatin-remodeling complex ATPase ISW1", "gene_name": "ISW1", "organism": "Yeast", "refseq_name": "chromatin-remodeling ATPase ISW1", "refseq_ac": [ { "id": "NP_009804", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009804", "type": "external" } ], "gene_names_uniprotkb": "ISW1; YBR1633", "gene_names_refseq": "ISW1; SGN2", "protein_names_uniprotkb": "ISWI chromatin-remodeling complex ATPase ISW1; 3.6.4.-", "protein_names_refseq": "chromatin-remodeling ATPase ISW1", "tax_id": 559292, "disease": "central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (sce:YBR245C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10090725;11238381;12482963;14562095;14562106;14622597;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;23749301;24374639;32597660;33229814;33481703;33491328;7813418", "class_list": "", "function": "Catalytic component of ISW1-type complexes, which act by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. They are involved in coordinating transcriptional repression, activation and elongation phases. The ISW1A complex represses gene expression at initiation through specific positioning of a promoter proximal dinucleosome. The ISW1B complex acts within coding regions to control the amount of RNA polymerase II released into productive elongation and to coordinate elongation with termination and pre-mRNA processing., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 29, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VQP1", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0000976 transcription cis-regulatory region binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0036436 Isw1a complex;GO:0036437 Isw1b complex;GO:0030874 nucleolar chromatin", "go_biological_process": "GO:0046832 negative regulation of RNA export from nucleus;GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P38144-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38146-1", "uniprot_id": [ { "id": "YPT10_YEAST", "url": "https://www.uniprot.org/uniprot/P38146", "type": "external" } ], "mass": 21834.0, "length": 199, "protein_name": "GTP-binding protein YPT10", "gene_name": "YPT10", "organism": "Yeast", "refseq_name": "Rab family GTPase YPT10", "refseq_ac": [ { "id": "NP_009823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009823", "type": "external" } ], "gene_names_uniprotkb": "YPT10; YBR1733", "gene_names_refseq": "YPT10", "protein_names_uniprotkb": "GTP-binding protein YPT10", "protein_names_refseq": "Rab family GTPase YPT10", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR264C); (R-SCE-6798695); (R-SCE-8873719); (R-SCE-8876198)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "10394895;11785952;11943201;12748633;14562095;14562106;18407956;23749301;24374639;32391792;32597660;33491328;37463208;7813418;8465606", "class_list": "", "function": "Protein transport. Probably involved in vesicular traffic (By similarity). Specifically binds guanine nucleotides (PubMed:10394895). In its GTP-bound active form may be involved in recruiting the MON1-CCZ1 complex to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns[3]P) or other charged lipids, leading to recruitment of YPT7 and downstream effectors involved in endolysosomal maturation (PubMed:32391792)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQR1", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0030234 enzyme regulator activity;GO:0019001 guanyl nucleotide binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0031982 vesicle;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P38146-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38149-1", "uniprot_id": [ { "id": "DUG2_YEAST", "url": "https://www.uniprot.org/uniprot/P38149", "type": "external" } ], "mass": 98071.0, "length": 878, "protein_name": "Probable di- and tripeptidase DUG2", "gene_name": "DUG2", "organism": "Yeast", "refseq_name": "glutamine amidotransferase subunit DUG2", "refseq_ac": [ { "id": "NP_009840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009840", "type": "external" } ], "gene_names_uniprotkb": "DUG2; YBR2018", "gene_names_refseq": "DUG2", "protein_names_uniprotkb": "Probable di- and tripeptidase DUG2; 3.4.-.-; Deficient in utilization of glutathione protein 2; GSH degradosomal complex subunit DUG2", "protein_names_refseq": "glutamine amidotransferase subunit DUG2", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR281C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;17179087;18407956;24374639;33491328;7813418;8091861", "class_list": "", "function": "Component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQS6", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008242 omega peptidase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0034399 nuclear periphery;GO:0061672 glutathione hydrolase complex", "go_biological_process": "GO:0006751 glutathione catabolic process;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38149-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38153-1", "uniprot_id": [ { "id": "AP3M_YEAST", "url": "https://www.uniprot.org/uniprot/P38153", "type": "external" } ], "mass": 54837.0, "length": 483, "protein_name": "AP-3 complex subunit mu", "gene_name": "APM3", "organism": "Yeast", "refseq_name": "Apm3p", "refseq_ac": [ { "id": "NP_009847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009847", "type": "external" } ], "gene_names_uniprotkb": "APM3; YBR2035; YKS6", "gene_names_refseq": "APM3; YKS6", "protein_names_uniprotkb": "AP-3 complex subunit mu; AP-3 adaptor complex mu3A subunit; Adaptor-related protein complex 3 subunit mu; Mu-adaptin 3A; Mu3-adaptin", "protein_names_refseq": "Apm3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR288C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10559961;14562095;14562106;18407956;19779198;24374639;33491328;7813418;8091861;9250663;9335339", "class_list": "", "function": "Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. Required for the transport via the ALP pathway, which directs the transport of the cargo proteins PHO8 and VAM3 to the vacuole., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQT3", "ec_number_list": [], "go_molecular_function": "GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0005802 trans-Golgi network;GO:0030123 AP-3 adaptor complex;GO:0030121 AP-1 adaptor complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0006623 protein targeting to vacuole;GO:0006896 Golgi to vacuole transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38153-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38165-1", "uniprot_id": [ { "id": "RTG3_YEAST", "url": "https://www.uniprot.org/uniprot/P38165", "type": "external" } ], "mass": 54140.0, "length": 486, "protein_name": "Retrograde regulation protein 3", "gene_name": "RTG3", "organism": "Yeast", "refseq_name": "Rtg3p", "refseq_ac": [ { "id": "NP_009447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009447", "type": "external" } ], "gene_names_uniprotkb": "RTG3; YBL0810", "gene_names_refseq": "RTG3", "protein_names_uniprotkb": "Retrograde regulation protein 3", "protein_names_refseq": "Rtg3p", "tax_id": 559292, "disease": "Tietz syndrome (Disease Ontology:DOID:0090002); ocular albinism with sensorineural deafness (Disease Ontology:DOID:0090100); Waardenburg syndrome type 1 (Disease Ontology:DOID:0110948); Waardenburg syndrome type 2A (Disease Ontology:DOID:0110950); osteopetrosis (Disease Ontology:DOID:13533); Tietze's syndrome (Disease Ontology:DOID:14021); melanoma (Disease Ontology:DOID:1909); lysosomal storage disease (Disease Ontology:DOID:3211); Camurati-Engelmann disease (Disease Ontology:DOID:4997); familial melanoma (Disease Ontology:DOID:6846); Waardenburg syndrome (Disease Ontology:DOID:9258)", "pathway": " (sce:YBL103C); (R-SCE-3232118); (R-SCE-9856649)", "pathway_count": 3, "publication_count": 24, "publication_id_list": "14562106;17330950;17467953;17563356;18407956;19684113;19779198;20489023;20702584;21126336;21177495;22218487;22814378;22956768;23749301;24374639;30516470;32597660;33229814;33481703;33491328;7502586;7813418;9032238", "class_list": "", "function": "Transcription factor that regulates CIT2 gene expression. Binds to two identical sites oriented as inverted repeats 28 bp apart in a regulatory upstream activation sequence element (UASR) in the CIT2 promoter. The core binding site is 5'-GGTCAC-3'., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 46, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "D6VPQ0;P89494", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0071400 cellular response to oleic acid;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016559 peroxisome fission;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P38165-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38193-1", "uniprot_id": [ { "id": "PP4R2_YEAST", "url": "https://www.uniprot.org/uniprot/P38193", "type": "external" } ], "mass": 50655.0, "length": 441, "protein_name": "Serine/threonine-protein phosphatase 4 regulatory subunit 2", "gene_name": "PSY4", "organism": "Yeast", "refseq_name": "Psy4p", "refseq_ac": [ { "id": "NP_009507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009507", "type": "external" } ], "gene_names_uniprotkb": "PSY4; HTP3; YBL0402", "gene_names_refseq": "HSM6; PSY4", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 4 regulatory subunit 2; PP4R2", "protein_names_refseq": "Psy4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL046W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "14562095;14562106;15665377;16085932;16299494;17322287;17563356;18407956;19520826;19779198;20190278;20489023;23749301;24374639;32597660;33481703;33491328;35977012;7813418;7871888", "class_list": "", "function": "Regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPV2;Q6B302", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030289 protein phosphatase 4 complex", "go_biological_process": "GO:0051598 meiotic recombination checkpoint signaling;GO:2000002 negative regulation of DNA damage checkpoint", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P38193-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38210-1", "uniprot_id": [ { "id": "LDB7_YEAST", "url": "https://www.uniprot.org/uniprot/P38210", "type": "external" } ], "mass": 19792.0, "length": 180, "protein_name": "Chromatin structure-remodeling complex protein RSC14", "gene_name": "LDB7", "organism": "Yeast", "refseq_name": "Ldb7p", "refseq_ac": [ { "id": "NP_009547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009547", "type": "external" } ], "gene_names_uniprotkb": "LDB7; RSC14; YBL0322", "gene_names_refseq": "LDB7; RSC14", "protein_names_uniprotkb": "Chromatin structure-remodeling complex protein RSC14; Low dye-binding protein 7; Remodel the structure of chromatin complex subunit 14", "protein_names_refseq": "Ldb7p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL006C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12748633;1441753;14587103;16204215;18407956;24374639;32597660;33491328;7813418", "class_list": "", "function": "Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. Together with HTL1, NPL6, RSC3, RSC30 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity. May be involved in the transfer of mannosylphosphate (MP) groups into N-linked oligosaccharides., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPZ4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000785 chromatin;GO:0016586 RSC-type complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006368 transcription elongation by RNA polymerase II;GO:0006337 nucleosome disassembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38210-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38217-1", "uniprot_id": [ { "id": "IMB2_YEAST", "url": "https://www.uniprot.org/uniprot/P38217", "type": "external" } ], "mass": 103681.0, "length": 918, "protein_name": "Importin subunit beta-2", "gene_name": "KAP104", "organism": "Yeast", "refseq_name": "Kap104p", "refseq_ac": [ { "id": "NP_009573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009573", "type": "external" } ], "gene_names_uniprotkb": "KAP104; YBR0224", "gene_names_refseq": "KAP104", "protein_names_uniprotkb": "Importin subunit beta-2; Importin-104; Karyopherin subunit beta-2; Karyopherin-104; TRN; Transportin", "protein_names_refseq": "Kap104p", "tax_id": 559292, "disease": "intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies (Disease Ontology:DOID:0081262)", "pathway": " (sce:YBR017C); (R-SCE-450513)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10506153;11423015;14562106;19366694;24374639;7762304;7813418;8849456;9321403;9488461", "class_list": "", "function": "Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Required for nuclear transport of NAB2, HRP1/NAB4 and TFG2. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins (PubMed:10506153, PubMed:19366694, PubMed:8849456, PubMed:9488461). The complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11423015). At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of the cargo. Efficient GTP-Ran-mediated substrate release requires RNA (PubMed:10506153). The importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11423015)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ19", "ec_number_list": [], "go_molecular_function": "GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005934 cellular bud tip", "go_biological_process": "GO:0010458 exit from mitosis;GO:0051028 mRNA transport;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38217-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38251-1", "uniprot_id": [ { "id": "RFC5_YEAST", "url": "https://www.uniprot.org/uniprot/P38251", "type": "external" } ], "mass": 39942.0, "length": 354, "protein_name": "Replication factor C subunit 5", "gene_name": "RFC5", "organism": "Yeast", "refseq_name": "replication factor C subunit 5", "refseq_ac": [ { "id": "NP_009644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009644", "type": "external" } ], "gene_names_uniprotkb": "RFC5; YBR0810", "gene_names_refseq": "RFC5", "protein_names_uniprotkb": "Replication factor C subunit 5; Activator 1 40 kDa subunit; Replication factor C5", "protein_names_refseq": "replication factor C subunit 5", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR087W); (R-SCE-176187); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-69091)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "10913172;11389843;11486023;12604797;12665596;12912927;14562106;15201901;15964801;17322287;21126336;24374639;7651383;7813418;7900426;8559655", "class_list": "", "function": "Component of ATP-dependent clamp loader (RFC and RFC-like) complexes for DNA clamps, such as the POL30/PCNA homotrimer and the checkpoint clamp DDC1:MEC3:RAD17 complex. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Component of the replication factor C (RFC or activator 1) complex which loads POL30/PCNA and acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. Component of the RFC-like RAD24-RFC complex which loads the checkpoint clamp DDC1:MEC3:RAD17 complex and is involved in DNA repair pathways. Component of the RFC-like ELG1-RFC complex which appears to have a role in DNA replication, replication fork re-start, recombination and repair., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ88", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0031390 Ctf18 RFC-like complex;GO:0031391 Elg1 RFC-like complex;GO:0005663 DNA replication factor C complex;GO:0031389 Rad17 RFC-like complex", "go_biological_process": "GO:0006272 leading strand elongation;GO:0006281 DNA repair;GO:0000077 DNA damage checkpoint signaling;GO:0007064 mitotic sister chromatid cohesion;GO:0007062 sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P38251-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38255-1", "uniprot_id": [ { "id": "RXT2_YEAST", "url": "https://www.uniprot.org/uniprot/P38255", "type": "external" } ], "mass": 48629.0, "length": 430, "protein_name": "Transcriptional regulatory protein RXT2", "gene_name": "RXT2", "organism": "Yeast", "refseq_name": "Rxt2p", "refseq_ac": [ { "id": "NP_009653", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009653", "type": "external" } ], "gene_names_uniprotkb": "RXT2; RAF60; YBR0822", "gene_names_refseq": "RAF60; RXT2", "protein_names_uniprotkb": "Transcriptional regulatory protein RXT2", "protein_names_refseq": "Rxt2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR095C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "12748633;14562095;14562106;16275642;16286008;16314178;17322287;17330950;18407956;19779198;20489023;21126336;21177495;23749301;24374639;33481703;33491328;7813418;7900426", "class_list": "", "function": "Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ96", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0070210 Rpd3L-Expanded complex;GO:0033698 Rpd3L complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006334 nucleosome assembly;GO:0061188 negative regulation of rDNA heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P38255-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38266-1", "uniprot_id": [ { "id": "AIM3_YEAST", "url": "https://www.uniprot.org/uniprot/P38266", "type": "external" } ], "mass": 103863.0, "length": 947, "protein_name": "Altered inheritance of mitochondria protein 3", "gene_name": "AIM3", "organism": "Yeast", "refseq_name": "Aim3p", "refseq_ac": [ { "id": "NP_009666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009666", "type": "external" } ], "gene_names_uniprotkb": "AIM3; YBR0901", "gene_names_refseq": "AIM3", "protein_names_uniprotkb": "Altered inheritance of mitochondria protein 3", "protein_names_refseq": "Aim3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR108W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "12748633;15561700;15665377;17287358;17563356;18407956;19300474;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;32597660;33229814;33481703;33491328;7813418;7900426", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 26, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 26, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 26, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 37, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 26, "binding_glycan_count": 0, "secondary_ac_list": "D6VQA7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0045121 membrane raft;GO:0030479 actin cortical patch", "go_biological_process": "GO:0051016 barbed-end actin filament capping;GO:0000147 actin cortical patch assembly", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "P38266-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38272-1", "uniprot_id": [ { "id": "SHE3_YEAST", "url": "https://www.uniprot.org/uniprot/P38272", "type": "external" } ], "mass": 47417.0, "length": 425, "protein_name": "SWI5-dependent HO expression protein 3", "gene_name": "SHE3", "organism": "Yeast", "refseq_name": "She3p", "refseq_ac": [ { "id": "NP_009688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009688", "type": "external" } ], "gene_names_uniprotkb": "SHE3; YBR1005", "gene_names_refseq": "SHE3", "protein_names_uniprotkb": "SWI5-dependent HO expression protein 3", "protein_names_refseq": "She3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR130C)", "pathway_count": 1, "publication_count": 34, "publication_id_list": "10212145;10359695;10792032;11032818;11101531;12499354;14561888;14562106;14691136;15328357;15665377;16890529;17287358;17330950;17563356;18407956;19429778;19684113;19779198;19795423;19823750;20439999;20702584;21126336;21177495;22218487;23749301;24374639;32597660;33481703;33491328;7813418;8091856;9809065", "class_list": "", "function": "RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Required for the delivery of cortical endoplasmic reticulum into the emerging bud., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 36, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQC7", "ec_number_list": [], "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0005934 cellular bud tip", "go_biological_process": "GO:0008298 intracellular mRNA localization;GO:0051028 mRNA transport;GO:0007533 mating type switching;GO:0048309 endoplasmic reticulum inheritance", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P38272-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38274-1", "uniprot_id": [ { "id": "HSL7_YEAST", "url": "https://www.uniprot.org/uniprot/P38274", "type": "external" } ], "mass": 95153.0, "length": 827, "protein_name": "Protein arginine N-methyltransferase HSL7", "gene_name": "HSL7", "organism": "Yeast", "refseq_name": "protein arginine N-methyltransferase", "refseq_ac": [ { "id": "NP_009691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009691", "type": "external" } ], "gene_names_uniprotkb": "HSL7; YBR1008", "gene_names_refseq": "HSL7", "protein_names_uniprotkb": "Protein arginine N-methyltransferase HSL7; 2.1.1.320; Histone synthetic lethal protein 7; Type II PRMT; Type II protein arginine N-methyltransferase", "protein_names_refseq": "protein arginine N-methyltransferase", "tax_id": 559292, "disease": "idiopathic scoliosis (Disease Ontology:DOID:0060250); Leydig cell tumor (Disease Ontology:DOID:2696); asthma (Disease Ontology:DOID:2841); seminoma (Disease Ontology:DOID:4440)", "pathway": " (sce:YBR133C)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10411908;10490630;10490648;10903903;11408575;14562106;16426232;17287358;17563356;18407956;18515076;23749301;24374639;24440502;32597660;33481703;33491328;7813418;8091856;8647431", "class_list": "", "function": "S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that can catalyze both the mono- and symmetric (type II) dimethylation of the guanidino nitrogens of arginine residues in target proteins (PubMed:18515076). Involved in the control of the cell cycle at the G2/M (mitosis) transition. Cooperates with HSL1 to hyperphosphorylate SWE1, thereby targeting SWE1 for polyubiquitination and subsequent degradation (PubMed:10490630, PubMed:10490648). Acts as a negative regulator of the filamentous growth-signaling pathway through inhibition of STE20 (PubMed:10411908)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2NP39;D6VQD0", "ec_number_list": [ { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" } ], "go_molecular_function": "GO:0042054 histone methyltransferase activity;GO:0035241 protein-arginine omega-N monomethyltransferase activity;GO:0035243 protein-arginine omega-N symmetric methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000144 cellular bud neck septin ring;GO:0005824 outer plaque of spindle pole body", "go_biological_process": "GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0006355 regulation of DNA-templated transcription;GO:0000902 cell morphogenesis;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P38274-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38287-1", "uniprot_id": [ { "id": "CSH1_YEAST", "url": "https://www.uniprot.org/uniprot/P38287", "type": "external" } ], "mass": 44382.0, "length": 376, "protein_name": "Mannosyl phosphorylinositol ceramide synthase CSH1", "gene_name": "CSH1", "organism": "Yeast", "refseq_name": "mannosylinositol phosphorylceramide synthase catalytic subunit CSH1", "refseq_ac": [ { "id": "NP_009719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009719", "type": "external" } ], "gene_names_uniprotkb": "CSH1; YBR1212", "gene_names_refseq": "CSH1", "protein_names_uniprotkb": "Mannosyl phosphorylinositol ceramide synthase CSH1; 2.4.1.370; CSG1/SUR1 homolog 1", "protein_names_refseq": "mannosylinositol phosphorylceramide synthase catalytic subunit CSH1", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR161W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12954640;14562095;14562106;17322287;17330950;24374639;32597660;33491328;35713525;7597849;7813418", "class_list": "glycogene;glycosyltransferase", "function": "Involved in the synthesis of mannosyl phosphorylinositol ceramide (PubMed:12954640). Catalyzes the addition of mannosyl to phosphorylinositol ceramide (PubMed:12954640)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VQF6", "ec_number_list": [ { "id": "2.4.1.370", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.370", "type": "external" } ], "go_molecular_function": "GO:0000030 mannosyltransferase activity;GO:0103064 inositol phosphorylceramide mannosyltransferase activity", "go_cellular_component": "GO:0031501 mannosyltransferase complex;GO:0005794 Golgi apparatus;GO:0005774 vacuolar membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0006676 mannosyl diphosphorylinositol ceramide metabolic process;GO:0051999 mannosyl-inositol phosphorylceramide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38287-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000100000001.010.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38297-1", "uniprot_id": [ { "id": "FZO1_YEAST", "url": "https://www.uniprot.org/uniprot/P38297", "type": "external" } ], "mass": 97808.0, "length": 855, "protein_name": "Mitofusin FZO1", "gene_name": "FZO1", "organism": "Yeast", "refseq_name": "mitofusin", "refseq_ac": [ { "id": "NP_009738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009738", "type": "external" } ], "gene_names_uniprotkb": "FZO1; YBR1241", "gene_names_refseq": "FZO1", "protein_names_uniprotkb": "Mitofusin FZO1; 3.6.5.-; Transmembrane GTPase FZO1", "protein_names_refseq": "mitofusin", "tax_id": 559292, "disease": "Charcot-Marie-Tooth disease type 2 (Disease Ontology:DOID:0050539); Charcot-Marie-Tooth disease type 6 (Disease Ontology:DOID:0080068); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Charcot-Marie-Tooth disease type 2A2A (Disease Ontology:DOID:0110155); Charcot-Marie-Tooth disease type 2A2B (Disease Ontology:DOID:0111557); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); adult respiratory distress syndrome (Disease Ontology:DOID:11394); prediabetes syndrome (Disease Ontology:DOID:11716); carotid stenosis (Disease Ontology:DOID:13001); dental fluorosis (Disease Ontology:DOID:13711); multiple symmetric lipomatosis (Disease Ontology:DOID:14116); primary pulmonary hypertension (Disease Ontology:DOID:14557); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); acute kidney failure (Disease Ontology:DOID:3021); pulmonary fibrosis (Disease Ontology:DOID:3770); rhinitis (Disease Ontology:DOID:4483); myocardial infarction (Disease Ontology:DOID:5844); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); chronic kidney disease (Disease Ontology:DOID:784); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YBR179C)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "10562274;11266460;12808034;14562095;14562106;15087460;15297626;15760898;16624808;16735578;18353967;19684113;19779198;19812251;20505073;20550520;21385840;21502136;22353369;23317502;23749301;24374639;27044889;27253069;28860650;33491328;7813418;9685359;9786948", "class_list": "", "function": "Essential transmembrane GTPase, which mediates mitochondrial fusion (PubMed:10562274, PubMed:11266460, PubMed:15297626, PubMed:15760898, PubMed:16624808, PubMed:19812251, PubMed:21385840, PubMed:21502136, PubMed:23317502, PubMed:27253069, PubMed:9685359, PubMed:9786948). Fusion proceeds through several steps; first mitochondria are tethered together, then brought into close contact, followed by the formation of a docking ring around contact areas, and finally membrane fusion (PubMed:27253069). Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondrial morphology, which is balanced between fusion and fission, mediated by FZO1 and DNM1, respectively (PubMed:10562274). Functions antagonistically with DNM1 (PubMed:10562274). Probably acts by forming membrane contact sites that mediate mitochondrial membrane fusion (PubMed:27253069). Mitochondrial docking and fusion requires GTP hydrolysis (PubMed:15297626, PubMed:19812251, PubMed:27253069). Mitochondrial fusion also promotes increased lifespan., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 34, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQH3", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0160190 peroxisome-mitochondrion membrane tether activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0031966 mitochondrial membrane;GO:0160189 peroxisomal-mitochondrial contact site", "go_biological_process": "GO:0008053 mitochondrial fusion;GO:0051646 mitochondrion localization;GO:0048312 intracellular distribution of mitochondria;GO:1990626 mitochondrial outer membrane fusion;GO:1990627 mitochondrial inner membrane fusion", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P38297-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38302-1", "uniprot_id": [ { "id": "NTC20_YEAST", "url": "https://www.uniprot.org/uniprot/P38302", "type": "external" } ], "mass": 15970.0, "length": 140, "protein_name": "Pre-mRNA-splicing factor NTC20", "gene_name": "NTC20", "organism": "Yeast", "refseq_name": "Ntc20p", "refseq_ac": [ { "id": "NP_009747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009747", "type": "external" } ], "gene_names_uniprotkb": "NTC20; SNT384; YBR1316", "gene_names_refseq": "NTC20", "protein_names_uniprotkb": "Pre-mRNA-splicing factor NTC20; PRP19-associated complex protein 20; Synergistic to PRP19 mutation protein 384", "protein_names_refseq": "Ntc20p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR188C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "11018040;11102353;11842115;11884590;12088152;12871902;14562095;14562106;17322287;18407956;19684113;19779198;19795423;19823750;21126336;23749301;24374639;32597660;33481703;33491328;7813418;7871891", "class_list": "", "function": "Involved in pre-mRNA splicing. As a component of the NTC complex, associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQI3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0071006 U2-type catalytic step 1 spliceosome;GO:0000974 Prp19 complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P38302-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38310-1", "uniprot_id": [ { "id": "FTH1_YEAST", "url": "https://www.uniprot.org/uniprot/P38310", "type": "external" } ], "mass": 51420.0, "length": 465, "protein_name": "Iron transporter FTH1", "gene_name": "FTH1", "organism": "Yeast", "refseq_name": "Fth1p", "refseq_ac": [ { "id": "NP_009766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009766", "type": "external" } ], "gene_names_uniprotkb": "FTH1; YBR1446", "gene_names_refseq": "FTH1", "protein_names_uniprotkb": "Iron transporter FTH1", "protein_names_refseq": "Fth1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR207W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10608875;14562095;14562106;16847258;17287358;17330950;17563356;18407956;19684113;19779198;20702584;23749301;24374639;30516470;32597660;33481703;33491328;7813418;8368014", "class_list": "", "function": "High affinity iron transporter probably involved in transport of intravacuolar stores of iron., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQK4;Q9URQ1", "ec_number_list": [], "go_molecular_function": "GO:0015093 ferrous iron transmembrane transporter activity;GO:0005381 iron ion transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0000329 fungal-type vacuole membrane;GO:0033573 high-affinity iron permease complex", "go_biological_process": "GO:0034755 iron ion transmembrane transport;GO:0006897 endocytosis;GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P38310-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38328-1", "uniprot_id": [ { "id": "ARPC1_YEAST", "url": "https://www.uniprot.org/uniprot/P38328", "type": "external" } ], "mass": 42475.0, "length": 384, "protein_name": "Actin-related protein 2/3 complex subunit 1", "gene_name": "ARC40", "organism": "Yeast", "refseq_name": "Arc40p", "refseq_ac": [ { "id": "NP_009793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009793", "type": "external" } ], "gene_names_uniprotkb": "ARC40; YBR1532", "gene_names_refseq": "ARC40", "protein_names_uniprotkb": "Actin-related protein 2/3 complex subunit 1; Arp2/3 complex 41 kDa subunit; p41-ARC", "protein_names_refseq": "Arc40p", "tax_id": 559292, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); myelodysplastic syndrome (Disease Ontology:DOID:0050908); immunodeficiency 71 (Disease Ontology:DOID:0112004); stomach cancer (Disease Ontology:DOID:10534); pancreatic cancer (Disease Ontology:DOID:1793); gastritis (Disease Ontology:DOID:4029); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (sce:YBR234C); (R-SCE-2029482); (R-SCE-5663213)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10377407;17322287;19779198;23749301;24374639;33491328;7813418", "class_list": "", "function": "Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQN0", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0005885 Arp2/3 protein complex;GO:0030479 actin cortical patch", "go_biological_process": "GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0045010 actin nucleation;GO:0044396 actin cortical patch organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38328-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38334-1", "uniprot_id": [ { "id": "TRS20_YEAST", "url": "https://www.uniprot.org/uniprot/P38334", "type": "external" } ], "mass": 19700.0, "length": 175, "protein_name": "Trafficking protein particle complex subunit 20", "gene_name": "TRS20", "organism": "Yeast", "refseq_name": "TRAPP subunit TRS20", "refseq_ac": [ { "id": "NP_009813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009813", "type": "external" } ], "gene_names_uniprotkb": "TRS20; YBR1722", "gene_names_refseq": "TRS20", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 20; TRAPP subunit 20; Transport protein particle 20 kDa subunit", "protein_names_refseq": "TRAPP subunit TRS20", "tax_id": 559292, "disease": "X-linked spondyloepiphyseal dysplasia tarda (Disease Ontology:DOID:0080362); spondyloepiphyseal dysplasia congenita (Disease Ontology:DOID:14789)", "pathway": " (sce:YBR254C); (R-SCE-204005); (R-SCE-8876198)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11239471;14562106;20375281;20972447;24374639;33491328;7813418;8465606;9564032", "class_list": "", "function": "Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQQ0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0016236 macroautophagy;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0006891 intra-Golgi vesicle-mediated transport;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38334-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38353-1", "uniprot_id": [ { "id": "SSH1_YEAST", "url": "https://www.uniprot.org/uniprot/P38353", "type": "external" } ], "mass": 53312.0, "length": 490, "protein_name": "Sec sixty-one protein homolog", "gene_name": "SSH1", "organism": "Yeast", "refseq_name": "Ssh1p", "refseq_ac": [ { "id": "NP_009842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009842", "type": "external" } ], "gene_names_uniprotkb": "SSH1; YBR2020", "gene_names_refseq": "SSH1", "protein_names_uniprotkb": "Sec sixty-one protein homolog; Ssh1 complex subunit SSH1; Ssh1 complex subunit alpha", "protein_names_refseq": "Ssh1p", "tax_id": 559292, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); autosomal dominant tubulointerstitial kidney disease 5 (Disease Ontology:DOID:0061120); common variable immunodeficiency (Disease Ontology:DOID:12177)", "pathway": " (sce:YBR283C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10775273;11702951;14562106;16847258;17322287;1764528;24374639;7813418;8091861;8612571", "class_list": "", "function": "Part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein endoplasmic reticulum (ER) import., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQS8", "ec_number_list": [], "go_molecular_function": "GO:0005048 signal sequence binding;GO:0043022 ribosome binding;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005784 Sec61 translocon complex;GO:0071261 Ssh1 translocon complex", "go_biological_process": "GO:0006614 SRP-dependent cotranslational protein targeting to membrane;GO:0031204 post-translational protein targeting to membrane, translocation;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38353-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38426-1", "uniprot_id": [ { "id": "TPS3_YEAST", "url": "https://www.uniprot.org/uniprot/P38426", "type": "external" } ], "mass": 118835.0, "length": 1054, "protein_name": "Trehalose synthase complex regulatory subunit TPS3", "gene_name": "TPS3", "organism": "Yeast", "refseq_name": "trehalose 6-phosphate synthase/phosphatase complex subunit", "refseq_ac": [ { "id": "NP_013988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013988", "type": "external" } ], "gene_names_uniprotkb": "TPS3; YM8156.03C", "gene_names_refseq": "TPS3", "protein_names_uniprotkb": "Trehalose synthase complex regulatory subunit TPS3; Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 115 kDa subunit", "protein_names_refseq": "trehalose 6-phosphate synthase/phosphatase complex subunit", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR261C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "11875433;14562095;14562106;15665377;17287358;17322287;17330950;17563356;18407956;19684113;19779198;20702584;21126336;21177495;23749301;24374639;30516470;32597660;33229814;33481703;33491328;9169872;9194697;9837904", "class_list": "", "function": "Regulatory subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a two step process. May stabilize the trehalose synthase complex., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 30, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 30, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 30, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 55, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 29, "binding_glycan_count": 0, "secondary_ac_list": "D6W087;Q6B1W2", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003824 catalytic activity;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)", "go_biological_process": "GO:0005992 trehalose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 5.6, "record_id": "P38426-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38427-1", "uniprot_id": [ { "id": "TSL1_YEAST", "url": "https://www.uniprot.org/uniprot/P38427", "type": "external" } ], "mass": 123018.0, "length": 1098, "protein_name": "Trehalose synthase complex regulatory subunit TSL1", "gene_name": "TSL1", "organism": "Yeast", "refseq_name": "trehalose 6-phosphate synthase/phosphatase complex subunit", "refseq_ac": [ { "id": "NP_013608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013608", "type": "external" } ], "gene_names_uniprotkb": "TSL1", "gene_names_refseq": "TSL1", "protein_names_uniprotkb": "Trehalose synthase complex regulatory subunit TSL1; Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 123 kDa subunit", "protein_names_refseq": "trehalose 6-phosphate synthase/phosphatase complex subunit", "tax_id": 559292, "disease": "", "pathway": " (sce:YML100W)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "11875433;14562095;14562106;15665377;17287358;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23273919;23749301;24374639;24909858;28270554;32597660;33229814;33481703;33491328;34965436;8404905;9169872;9194697;9837904", "class_list": "", "function": "Regulatory subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a two step process. May stabilize the trehalose synthase complex, and confer sensitivity to physiological concentrations of phosphate and to fructose 6-phosphate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 47, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6W0I5", "ec_number_list": [], "go_molecular_function": "GO:0003824 catalytic activity;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)", "go_biological_process": "GO:0005992 trehalose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P38427-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38623-1", "uniprot_id": [ { "id": "RCK2_YEAST", "url": "https://www.uniprot.org/uniprot/P38623", "type": "external" } ], "mass": 68062.0, "length": 610, "protein_name": "Serine/threonine-protein kinase RCK2", "gene_name": "RCK2", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase RCK2", "refseq_ac": [ { "id": "NP_013349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013349", "type": "external" } ], "gene_names_uniprotkb": "RCK2; CLK1; CMK3; L9672.6", "gene_names_refseq": "CLK1; CMK3; RCK2", "protein_names_uniprotkb": "Serine/threonine-protein kinase RCK2; 2.7.11.1; CAM kinase-like protein kinase CLK1", "protein_names_refseq": "serine/threonine protein kinase RCK2", "tax_id": 559292, "disease": "autosomal dominant intellectual developmental disorder 59 (Disease Ontology:DOID:0061033); autosomal dominant intellectual developmental disorder 53 (Disease Ontology:DOID:0080228); autosomal dominant intellectual developmental disorder 54 (Disease Ontology:DOID:0080230); autosomal recessive intellectual developmental disorder 63 (Disease Ontology:DOID:0081224); heart conduction disease (Disease Ontology:DOID:10273); Alzheimer's disease (Disease Ontology:DOID:10652); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (sce:YLR248W)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "10805732;11344302;14562095;14562106;14735355;15665377;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;28270554;30516470;31208443;32597660;33481703;33491328;8112585;8939941;9169871", "class_list": "", "function": "Serine/threonine-protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VYP6;Q02532;Q06557", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007231 osmosensory signaling pathway;GO:0007165 signal transduction;GO:0034599 cellular response to oxidative stress;GO:0040020 regulation of meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P38623-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38629-1", "uniprot_id": [ { "id": "RFC3_YEAST", "url": "https://www.uniprot.org/uniprot/P38629", "type": "external" } ], "mass": 38204.0, "length": 340, "protein_name": "Replication factor C subunit 3", "gene_name": "RFC3", "organism": "Yeast", "refseq_name": "replication factor C subunit 3", "refseq_ac": [ { "id": "NP_014109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014109", "type": "external" } ], "gene_names_uniprotkb": "RFC3; N0533", "gene_names_refseq": "RFC3", "protein_names_uniprotkb": "Replication factor C subunit 3; Activator 1 40 kDa subunit; Replication factor C3", "protein_names_refseq": "replication factor C subunit 3", "tax_id": 559292, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (sce:YNL290W); (R-SCE-176187); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-69091)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "10660302;11389843;11486023;12604797;12665596;14530260;14562106;15201901;15964801;22814378;24374639;33491328;7651383;8302859;8553702;9169873", "class_list": "", "function": "Component of ATP-dependent clamp loader (RFC and RFC-like) complexes for DNA clamps, such as the POL30/PCNA homotrimer and the checkpoint clamp DDC1:MEC3:RAD17 complex. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Component of the replication factor C (RFC or activator 1) complex which loads POL30/PCNA and acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. Component of the RFC-like RAD24-RFC complex which loads the checkpoint clamp DDC1:MEC3:RAD17 complex and is involved in DNA repair pathways. Component of the RFC-like ELG1-RFC complex which appears to have a role in DNA replication, replication fork re-start, recombination and repair. RFC3 supplies a catalytic site to the ATP site of RFC4., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0Q3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0031390 Ctf18 RFC-like complex;GO:0031391 Elg1 RFC-like complex;GO:0005663 DNA replication factor C complex", "go_biological_process": "GO:0006272 leading strand elongation;GO:0006281 DNA repair;GO:0006298 mismatch repair;GO:0000077 DNA damage checkpoint signaling;GO:0007064 mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P38629-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38633-1", "uniprot_id": [ { "id": "MED31_YEAST", "url": "https://www.uniprot.org/uniprot/P38633", "type": "external" } ], "mass": 14741.0, "length": 127, "protein_name": "Mediator of RNA polymerase II transcription subunit 31", "gene_name": "SOH1", "organism": "Yeast", "refseq_name": "mediator complex subunit SOH1", "refseq_ac": [ { "id": "NP_011388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011388", "type": "external" } ], "gene_names_uniprotkb": "SOH1; G2864; MED31", "gene_names_refseq": "MED31; SOH1", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 31; Hpr1 suppressor protein 1; Mediator complex subunit 31", "protein_names_refseq": "mediator complex subunit SOH1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL127C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12191485;14562095;14562106;15175151;15356001;15477388;16002404;16076843;16109375;16263706;17322287;22218487;24374639;33491328;7982575;8686378;9169869", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VU21", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P38633-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38689-1", "uniprot_id": [ { "id": "KPR3_YEAST", "url": "https://www.uniprot.org/uniprot/P38689", "type": "external" } ], "mass": 35124.0, "length": 320, "protein_name": "Ribose-phosphate pyrophosphokinase 3", "gene_name": "PRS3", "organism": "Yeast", "refseq_name": "ribose phosphate diphosphokinase subunit PRS3", "refseq_ac": [ { "id": "NP_011852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011852", "type": "external" } ], "gene_names_uniprotkb": "PRS3; PRPS3", "gene_names_refseq": "PRS3", "protein_names_uniprotkb": "Ribose-phosphate pyrophosphokinase 3; 2.7.6.1; Phosphoribosyl pyrophosphate synthase 3", "protein_names_refseq": "ribose phosphate diphosphokinase subunit PRS3", "tax_id": 559292, "disease": "Arts syndrome (Disease Ontology:DOID:0050647); Charcot-Marie-Tooth disease X-linked recessive 5 (Disease Ontology:DOID:0110210); phosphoribosylpyrophosphate synthetase superactivity (Disease Ontology:DOID:0111260); X-linked deafness 1 (Disease Ontology:DOID:0111739); retinitis pigmentosa (Disease Ontology:DOID:10584); gout (Disease Ontology:DOID:13189)", "pathway": " (sce:YHL011C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10212224;10514564;14562095;15280369;17322287;22814378;24374639;33491328;7992503;8091229", "class_list": "", "function": "5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKQ2", "ec_number_list": [ { "id": "2.7.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.6.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0004749 ribose phosphate diphosphokinase activity", "go_cellular_component": "GO:0002189 ribose phosphate diphosphokinase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0009156 ribonucleoside monophosphate biosynthetic process;GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process;GO:0006164 purine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38689-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38691-1", "uniprot_id": [ { "id": "KSP1_YEAST", "url": "https://www.uniprot.org/uniprot/P38691", "type": "external" } ], "mass": 117082.0, "length": 1029, "protein_name": "Serine/threonine-protein kinase KSP1", "gene_name": "KSP1", "organism": "Yeast", "refseq_name": "putative serine/threonine protein kinase KSP1", "refseq_ac": [ { "id": "NP_011950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011950", "type": "external" } ], "gene_names_uniprotkb": "KSP1", "gene_names_refseq": "KSP1", "protein_names_uniprotkb": "Serine/threonine-protein kinase KSP1; 2.7.11.1", "protein_names_refseq": "putative serine/threonine protein kinase KSP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR082C)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "11875433;14562106;15665377;17287358;17330950;18407956;19684113;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22218487;22447937;23749301;24374639;29438499;30516470;32597660;33229814;33481703;33491328;34965436;8091229;8676864", "class_list": "", "function": "May act on PRP20., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 66, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D3DL33", "ec_number_list": [ { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0043555 regulation of translation in response to stress;GO:0000086 G2/M transition of mitotic cell cycle;GO:0031929 TOR signaling;GO:0008104 intracellular protein localization;GO:0016242 negative regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P38691-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38696-1", "uniprot_id": [ { "id": "ARP1_YEAST", "url": "https://www.uniprot.org/uniprot/P38696", "type": "external" } ], "mass": 42995.0, "length": 384, "protein_name": "Centractin", "gene_name": "ARP1", "organism": "Yeast", "refseq_name": "actin-related protein 1", "refseq_ac": [ { "id": "NP_011997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011997", "type": "external" } ], "gene_names_uniprotkb": "ARP1; ACT3; ACT5", "gene_names_refseq": "ACT5; ARP1", "protein_names_uniprotkb": "Centractin; Actin-like protein; Actin-related protein 1", "protein_names_refseq": "actin-related protein 1", "tax_id": 559292, "disease": "Down syndrome (Disease Ontology:DOID:14250); colon cancer (Disease Ontology:DOID:219)", "pathway": " (sce:YHR129C); (R-SCE-6798695)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14562106;15311283;15975903;16291862;16415535;17322287;24374639;7929558;8069915;8091229;9658168", "class_list": "", "function": "Core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding (By similarity). The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. ARP1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits. Required for proper orientation of the mitotic spindle., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 42, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL78;Q6B1J6", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005874 microtubule;GO:0015629 actin cytoskeleton;GO:0016020 membrane;GO:0005869 dynactin complex;GO:0030286 dynein complex", "go_biological_process": "GO:0030048 actin filament-based movement;GO:0000132 establishment of mitotic spindle orientation;GO:0007097 nuclear migration;GO:0031578 mitotic spindle orientation checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38696-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38700-1", "uniprot_id": [ { "id": "APM2_YEAST", "url": "https://www.uniprot.org/uniprot/P38700", "type": "external" } ], "mass": 69990.0, "length": 605, "protein_name": "Adaptin medium chain homolog APM2", "gene_name": "APM2", "organism": "Yeast", "refseq_name": "Apm2p", "refseq_ac": [ { "id": "NP_011844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011844", "type": "external" } ], "gene_names_uniprotkb": "APM2", "gene_names_refseq": "APM2", "protein_names_uniprotkb": "Adaptin medium chain homolog APM2; Adaptin-mu1-II", "protein_names_refseq": "Apm2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHL019C); (R-SCE-432720)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10564262;14562106;24374639;26658609;33481703;33491328;7749194;8091229", "class_list": "", "function": "Component of the AP-1-related (AP-1R) complex, an adapter protein complex that mediates of cargo protein sorting in clathrin-coated vesicles (PubMed:26658609). AP-1R has a specific role in SNARE SNC1 sorting (PubMed:26658609). In contrast to the APM1-containing AP-1 complex, AP-1R is incapable of sorting CHS3 (PubMed:26658609)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DKR4", "ec_number_list": [], "go_molecular_function": "GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005769 early endosome;GO:0005829 cytosol;GO:0031901 early endosome membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0048203 vesicle targeting, trans-Golgi to endosome;GO:0006896 Golgi to vacuole transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38700-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38703-1", "uniprot_id": [ { "id": "LAG1_YEAST", "url": "https://www.uniprot.org/uniprot/P38703", "type": "external" } ], "mass": 48455.0, "length": 411, "protein_name": "Ceramide synthase LAG1", "gene_name": "LAG1", "organism": "Yeast", "refseq_name": "sphingosine N-acyltransferase LAG1", "refseq_ac": [ { "id": "NP_011860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011860", "type": "external" } ], "gene_names_uniprotkb": "LAG1", "gene_names_refseq": "LAG1", "protein_names_uniprotkb": "Ceramide synthase LAG1; 2.3.1.297; Longevity assurance factor 1; Longevity assurance gene 1 protein; Longevity assurance protein 1; Very-long-chain ceramide synthase LAG1", "protein_names_refseq": "sphingosine N-acyltransferase LAG1", "tax_id": 559292, "disease": "autosomal recessive congenital ichthyosis 9 (Disease Ontology:DOID:0060718); sciatic neuropathy (Disease Ontology:DOID:11446); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (sce:YHL003C); (R-SCE-1660661)", "pathway_count": 2, "publication_count": 31, "publication_id_list": "10198056;11387200;11694577;12151215;12869556;14562095;15236759;15302821;15692566;16756512;16847258;17322287;17330950;17563356;18407956;19684113;19779198;21177495;22814378;23749301;24374639;26726837;31164445;32597660;33481703;33491328;34492164;37953642;39528796;8091229;8195187", "class_list": "", "function": "Component of the ceramide synthase complex that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward hexacosanoyl-CoA (C26:0-CoA) (PubMed:11694577, PubMed:12869556, PubMed:37953642). N-acylates sphinganine and phytosphingosine bases to form dihydroceramides and phytoceramides, respectively (PubMed:12869556). Has a higher affinity for phytosphingosine (PHS) than dihydrosphingosine (DHS), and thus preferentially produces phytoceramides for the establishment of lateral diffusion barriers in the cortical endoplasmic reticulum and nuclear envelope (PubMed:31164445). Redundant with LAC1 but requires SUR2 to compensate for sphingolipid biosynthesis (PubMed:31164445, PubMed:39528796). Disruption or inhibition of sphingolipid synthesis leads to the activation and phosphorylation of YPK1 through the TORC2 and PKH1 pathways, which phosphorylates ORM1 and LAG1 to activate sphingolipid synthesis (PubMed:34492164). Facilitates ER-to-Golgi transport of GPI-anchored proteins. Involved in the aging process. Along with LAC1, plays a role in pheromone-induced MAP kinase-activation of mating and formation of diploid cells (PubMed:26726837). May also play a role, together with LAC1, in the polarized membrane distribution of phosphatidylinositol 4,5 biphosphate required for STE5 localization to the plasma membrane (PubMed:26726837)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DKR1;Q6LD26", "ec_number_list": [ { "id": "2.3.1.297", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.297", "type": "external" } ], "go_molecular_function": "GO:0050291 sphingosine N-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0061576 acyl-CoA ceramide synthase complex", "go_biological_process": "GO:0046513 ceramide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P38703-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38713-1", "uniprot_id": [ { "id": "OSH3_YEAST", "url": "https://www.uniprot.org/uniprot/P38713", "type": "external" } ], "mass": 113760.0, "length": 996, "protein_name": "Oxysterol-binding protein homolog 3", "gene_name": "OSH3", "organism": "Yeast", "refseq_name": "oxysterol-binding protein related protein OSH3", "refseq_ac": [ { "id": "NP_011940", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011940", "type": "external" } ], "gene_names_uniprotkb": "OSH3", "gene_names_refseq": "OSH3", "protein_names_uniprotkb": "Oxysterol-binding protein homolog 3; ORP 3; OSBP-related protein 3; Oxysterol-binding protein-related protein 3", "protein_names_refseq": "oxysterol-binding protein related protein OSH3", "tax_id": 559292, "disease": "cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (sce:YHR073W); (R-SCE-192105)", "pathway_count": 2, "publication_count": 30, "publication_id_list": "11238399;11408574;12049664;12727870;14562106;15023338;15173322;16585271;17287358;17330950;17563356;18407956;19779198;19795423;19823750;20008566;20702584;21126336;21177495;21295699;22814378;23749301;23791945;24213531;24374639;32597660;33481703;33491328;34965436;8091229", "class_list": "", "function": "Lipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes. Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol. Involved in maintenance of intracellular sterol distribution and homeostasis (PubMed:11238399, PubMed:15173322). May serve as a sensor of PI4P levels at PM-ER membrane contact site, regulating PI4P phosphatase SAC1 activity (PubMed:21295699). May be involved in ergosterol transport from the plasma membrane (PM) to the ER, however it does not bind sterols directly (PubMed:16585271, PubMed:23791945). Plays a role in the positive regulation of vesicular transport of ceramide from the ER to the Golgi, negatively regulating COPII-mediated ER export of cargos (PubMed:24213531)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 52, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DL23", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0032934 sterol binding;GO:0120015 sterol transfer activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0097038 perinuclear endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0006887 exocytosis;GO:0030011 maintenance of cell polarity;GO:0034727 piecemeal microautophagy of the nucleus;GO:0035621 ER to Golgi ceramide transport", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P38713-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38719-1", "uniprot_id": [ { "id": "DBP8_YEAST", "url": "https://www.uniprot.org/uniprot/P38719", "type": "external" } ], "mass": 47878.0, "length": 431, "protein_name": "ATP-dependent RNA helicase DBP8", "gene_name": "DBP8", "organism": "Yeast", "refseq_name": "ATP-dependent RNA helicase DBP8", "refseq_ac": [ { "id": "NP_012039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012039", "type": "external" } ], "gene_names_uniprotkb": "DBP8", "gene_names_refseq": "DBP8", "protein_names_uniprotkb": "ATP-dependent RNA helicase DBP8; 3.6.4.13; DEAD box protein 8", "protein_names_refseq": "ATP-dependent RNA helicase DBP8", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR169W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11222764;14562095;14562106;16772403;24374639;8091229", "class_list": "", "function": "ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLB8", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.1.1.260", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.260", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030686 90S preribosome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P38719-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38759-1", "uniprot_id": [ { "id": "VPS29_YEAST", "url": "https://www.uniprot.org/uniprot/P38759", "type": "external" } ], "mass": 31013.0, "length": 282, "protein_name": "Vacuolar protein sorting-associated protein 29", "gene_name": "VPS29", "organism": "Yeast", "refseq_name": "retromer subunit VPS29", "refseq_ac": [ { "id": "NP_011876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011876", "type": "external" } ], "gene_names_uniprotkb": "VPS29; PEP11; VTP6", "gene_names_refseq": "PEP11; VPS29; VPT6", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 29; Carboxypeptidase Y-deficient protein 11; Vesicle protein sorting 29", "protein_names_refseq": "retromer subunit VPS29", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR012W); (R-SCE-3238698)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14562106;18407956;21126336;21177495;22814378;24374639;32597660;33491328;8091229;9700157", "class_list": "", "function": "Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor VPS10. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS29-VPS26-VPS35 subcomplex may be involved in cargo selection., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKV7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030906 retromer, cargo-selective complex;GO:0005768 endosome;GO:0005829 cytosol;GO:0012505 endomembrane system;GO:0030904 retromer complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38759-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38764-1", "uniprot_id": [ { "id": "RPN1_YEAST", "url": "https://www.uniprot.org/uniprot/P38764", "type": "external" } ], "mass": 109492.0, "length": 993, "protein_name": "26S proteasome regulatory subunit RPN1", "gene_name": "RPN1", "organism": "Yeast", "refseq_name": "proteasome regulatory particle base subunit RPN1", "refseq_ac": [ { "id": "NP_011892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011892", "type": "external" } ], "gene_names_uniprotkb": "RPN1; HRD2; NAS1; RPD1", "gene_names_refseq": "HRD2; NAS1; RPN1", "protein_names_uniprotkb": "26S proteasome regulatory subunit RPN1; HMG-CoA reductase degradation protein 2; Proteasome non-ATPase subunit 1", "protein_names_refseq": "proteasome regulatory particle base subunit RPN1", "tax_id": 559292, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (sce:YHR027C); (R-SCE-1236978); (R-SCE-5668541); (R-SCE-5689880); (R-SCE-6798695); (R-SCE-9907900)", "pathway_count": 6, "publication_count": 24, "publication_id_list": "12504901;14562106;17287358;17330950;17563356;18407956;19779198;19795423;19823750;20486117;20702584;21126336;21177495;22218487;23749301;24374639;27821475;30181345;32597660;33481703;33491328;34965436;8091229;9584156", "class_list": "", "function": "Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 29, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKX4", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0008540 proteasome regulatory particle, base subcomplex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0042176 regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P38764-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38782-1", "uniprot_id": [ { "id": "MED6_YEAST", "url": "https://www.uniprot.org/uniprot/P38782", "type": "external" } ], "mass": 32819.0, "length": 295, "protein_name": "Mediator of RNA polymerase II transcription subunit 6", "gene_name": "MED6", "organism": "Yeast", "refseq_name": "mediator complex subunit MED6", "refseq_ac": [ { "id": "NP_011925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011925", "type": "external" } ], "gene_names_uniprotkb": "MED6; MTR32", "gene_names_refseq": "MED6", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 6; Mediator complex subunit 6", "protein_names_refseq": "mediator complex subunit MED6", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR058C)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "12191485;14562095;14562106;15175151;15477388;15710619;16002404;16076843;16263706;16885025;17192271;18407956;19779198;23749301;24374639;32597660;33481703;33491328;7479899;8091229;9234719;9671455;9845373", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL07", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P38782-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38788-1", "uniprot_id": [ { "id": "SSZ1_YEAST", "url": "https://www.uniprot.org/uniprot/P38788", "type": "external" } ], "mass": 58238.0, "length": 538, "protein_name": "Ribosome-associated complex subunit SSZ1", "gene_name": "SSZ1", "organism": "Yeast", "refseq_name": "ribosome-associated complex protein SSZ1", "refseq_ac": [ { "id": "NP_011931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011931", "type": "external" } ], "gene_names_uniprotkb": "SSZ1; PDR13", "gene_names_refseq": "PDR13; SSZ1", "protein_names_uniprotkb": "Ribosome-associated complex subunit SSZ1; DnaK-related protein SSZ1; Heat shock protein 70 homolog SSZ1; Pleiotropic drug resistance protein 13", "protein_names_refseq": "ribosome-associated complex protein SSZ1", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR064C); (R-SCE-3371453); (R-SCE-3371497); (R-SCE-3371568); (R-SCE-3371571); (R-SCE-6798695); (R-SCE-8876725)", "pathway_count": 7, "publication_count": 30, "publication_id_list": "11054575;11274393;11929993;12748633;14562095;14562106;15456889;15665377;15908962;17287358;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33481703;33491328;8091229;8962070", "class_list": "", "function": "Component of the ribosome-associated complex (RAC), a heterodimeric chaperone complex involved in regulation of accurate translation termination and in folding or maintaining nascent polypeptides in a folding-competent state. RAC stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones SSB1/SSB2 that bind to the nascent polypeptide chain. SSZ1 is required for ZUO1 to function efficiently as a J-protein for SSB1/SSB2. Also involved in pleiotropic drug resistance by post-translational activation of transcription factor PDR1., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL13;Q6B1F3;Q6TQT7;Q6TQT8", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0051083 'de novo' cotranslational protein folding;GO:0006457 protein folding;GO:0006364 rRNA processing;GO:0042026 protein refolding;GO:0006452 translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P38788-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38789-1", "uniprot_id": [ { "id": "SSF1_YEAST", "url": "https://www.uniprot.org/uniprot/P38789", "type": "external" } ], "mass": 51764.0, "length": 453, "protein_name": "Ribosome biogenesis protein SSF1", "gene_name": "SSF1", "organism": "Yeast", "refseq_name": "rRNA-binding ribosome biosynthesis protein", "refseq_ac": [ { "id": "NP_011933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011933", "type": "external" } ], "gene_names_uniprotkb": "SSF1", "gene_names_refseq": "SSF1", "protein_names_uniprotkb": "Ribosome biogenesis protein SSF1", "protein_names_refseq": "rRNA-binding ribosome biosynthesis protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR066W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11864607;12702244;14562106;17330950;18407956;19779198;23749301;24374639;30516470;32597660;33481703;33491328;7748491;8091229", "class_list": "", "function": "Required for biogenesis of the 60S ribosomal subunit., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DL15", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0000027 ribosomal large subunit assembly;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0008361 regulation of cell size", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P38789-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38811-1", "uniprot_id": [ { "id": "TRA1_YEAST", "url": "https://www.uniprot.org/uniprot/P38811", "type": "external" } ], "mass": 433180.0, "length": 3744, "protein_name": "SAGA complex/NuA4 acetyltransferase complex subunit TRA1", "gene_name": "TRA1", "organism": "Yeast", "refseq_name": "histone acetyltransferase TRA1", "refseq_ac": [ { "id": "NP_011967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011967", "type": "external" } ], "gene_names_uniprotkb": "TRA1", "gene_names_refseq": "TRA1", "protein_names_uniprotkb": "SAGA complex/NuA4 acetyltransferase complex subunit TRA1; Transcription-associated protein 1; p400 kDa component of SAGA", "protein_names_refseq": "histone acetyltransferase TRA1", "tax_id": 559292, "disease": "autosomal dominant nonsyndromic deafness (Disease Ontology:DOID:0050564); autosomal dominant nonsyndromic deafness 75 (Disease Ontology:DOID:0112166)", "pathway": " (sce:YHR099W)", "pathway_count": 1, "publication_count": 39, "publication_id_list": "10026213;10487762;10864329;10911987;11423663;12186975;12446794;14690591;15260971;15647753;16135807;17563356;18407956;18616809;19779198;19795423;19823750;20489023;20635087;20702584;21126336;22814378;23749301;24374639;25216679;28767037;28918903;29559617;31069110;31969703;32597660;33481703;33491328;33864814;36198799;36417436;8091229;9756893;9885573", "class_list": "", "function": "Essential scaffold subunit of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription (PubMed:10864329, PubMed:25216679, PubMed:28918903). At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module) (PubMed:11423663). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B (PubMed:10026213). SAGA interacts with DNA via upstream activating sequences (UASs) (PubMed:28918903, PubMed:36198799). Also identified in a modified version of SAGA named SALSA or SLIK (PubMed:12186975, PubMed:12446794). The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities (PubMed:33864814). Component of the NuA4 histone H4/H2A acetyltransferase involved in transcription and DNA repair (PubMed:10487762, PubMed:10911987, PubMed:16135807)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DL49", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000124 SAGA complex;GO:0046695 SLIK (SAGA-like) complex;GO:0110078 TTT Hsp90 cochaperone complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P38811-1", "record_type": "protein", "filter_code": "0000000.0100111.001000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38873-1", "uniprot_id": [ { "id": "KOG1_YEAST", "url": "https://www.uniprot.org/uniprot/P38873", "type": "external" } ], "mass": 177609.0, "length": 1557, "protein_name": "Target of rapamycin complex 1 subunit KOG1", "gene_name": "KOG1", "organism": "Yeast", "refseq_name": "ubiquitin-binding TORC1 subunit KOG1", "refseq_ac": [ { "id": "NP_012056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012056", "type": "external" } ], "gene_names_uniprotkb": "KOG1; H9998.14; LAS24", "gene_names_refseq": "KOG1; LAS24", "protein_names_uniprotkb": "Target of rapamycin complex 1 subunit KOG1; Kontroller of growth protein 1; Local anesthetic-sensitive protein 24; Raptor; Regulatory-associated protein of TOR; TORC1 subunit KOG1", "protein_names_refseq": "ubiquitin-binding TORC1 subunit KOG1", "tax_id": 559292, "disease": "nicotine dependence (Disease Ontology:DOID:0050742)", "pathway": " (sce:YHR186C); (R-SCE-3371571); (R-SCE-9639288)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "11875433;12408816;12631735;14562095;16394584;18407956;19779198;21126336;23749301;24374639;26439012;28483912;29698392;32597660;33481703;33491328;33853774;8091229", "class_list": "", "function": "Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. KOG1 may have a role in binding and recruiting substrates of TORC1., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DLD4", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0010494 cytoplasmic stress granule;GO:0031931 TORC1 complex", "go_biological_process": "GO:0007584 response to nutrient;GO:0010506 regulation of autophagy;GO:0030307 positive regulation of cell growth;GO:0001558 regulation of cell growth;GO:0031929 TOR signaling", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P38873-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38886-1", "uniprot_id": [ { "id": "RPN10_YEAST", "url": "https://www.uniprot.org/uniprot/P38886", "type": "external" } ], "mass": 29747.0, "length": 268, "protein_name": "26S proteasome regulatory subunit RPN10", "gene_name": "RPN10", "organism": "Yeast", "refseq_name": "proteasome regulatory particle base subunit RPN10", "refseq_ac": [ { "id": "NP_012070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012070", "type": "external" } ], "gene_names_uniprotkb": "RPN10; MCB1; SUN1", "gene_names_refseq": "MCB1; RPN10; SUN1", "protein_names_uniprotkb": "26S proteasome regulatory subunit RPN10", "protein_names_refseq": "proteasome regulatory particle base subunit RPN10", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR200W); (R-SCE-9907900)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "12504901;14562106;17190603;17322287;17563356;20486117;22814378;22927375;23749301;24374639;33481703;33491328;8091229;8887631;9017604", "class_list": "", "function": "Multiubiquitin binding protein., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLE9", "ec_number_list": [], "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0000502 proteasome complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P38886-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38932-1", "uniprot_id": [ { "id": "VPS45_YEAST", "url": "https://www.uniprot.org/uniprot/P38932", "type": "external" } ], "mass": 67017.0, "length": 577, "protein_name": "Vacuolar protein sorting-associated protein 45", "gene_name": "VPS45", "organism": "Yeast", "refseq_name": "Vps45p", "refseq_ac": [ { "id": "NP_011420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011420", "type": "external" } ], "gene_names_uniprotkb": "VPS45; STT10; VPL28", "gene_names_refseq": "STT10; VPL28; VPS45", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 45", "protein_names_refseq": "Vps45p", "tax_id": 559292, "disease": "severe congenital neutropenia 5 (Disease Ontology:DOID:0112132)", "pathway": " (sce:YGL095C); (R-SCE-983231)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10359603;12756236;14562106;17287358;24374639;7628704;7706396;7720726;9169869;9290212;9930650", "class_list": "", "function": "Essential for vacuolar protein sorting. Function in membrane traffic between the Golgi and the vacuole., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU50", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005774 vacuolar membrane;GO:0031201 SNARE complex", "go_biological_process": "GO:0048210 Golgi vesicle fusion to target membrane;GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0006895 Golgi to endosome transport;GO:0007033 vacuole organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38932-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38960-1", "uniprot_id": [ { "id": "STN1_YEAST", "url": "https://www.uniprot.org/uniprot/P38960", "type": "external" } ], "mass": 57511.0, "length": 494, "protein_name": "Protein STN1", "gene_name": "STN1", "organism": "Yeast", "refseq_name": "Stn1p", "refseq_ac": [ { "id": "NP_010367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010367", "type": "external" } ], "gene_names_uniprotkb": "STN1; D4456; YD8554.15", "gene_names_refseq": "STN1", "protein_names_uniprotkb": "Protein STN1", "protein_names_refseq": "Stn1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR082W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11230140;11230149;17322287;18407956;20008938;24164896;24374639;7483840;9042864;9169867", "class_list": "", "function": "Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS69", "ec_number_list": [], "go_molecular_function": "GO:0043047 single-stranded telomeric DNA binding;GO:0061770 translation elongation factor binding", "go_cellular_component": "GO:0000781 chromosome, telomeric region;GO:1990879 CST complex", "go_biological_process": "GO:0016233 telomere capping;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0032210 regulation of telomere maintenance via telomerase", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38960-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38989-1", "uniprot_id": [ { "id": "SMC2_YEAST", "url": "https://www.uniprot.org/uniprot/P38989", "type": "external" } ], "mass": 133928.0, "length": 1170, "protein_name": "Structural maintenance of chromosomes protein 2", "gene_name": "SMC2", "organism": "Yeast", "refseq_name": "condensin subunit SMC2", "refseq_ac": [ { "id": "NP_116687", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116687", "type": "external" } ], "gene_names_uniprotkb": "SMC2", "gene_names_refseq": "SMC2", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 2; DA-box protein SMC2", "protein_names_refseq": "condensin subunit SMC2", "tax_id": 559292, "disease": "colon adenocarcinoma (Disease Ontology:DOID:234); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YFR031C); (R-SCE-2514853)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10811823;14562106;18407956;24374639;33491328;7670463;7698648;8686381", "class_list": "", "function": "Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTR1", "ec_number_list": [], "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0000793 condensed chromosome;GO:0000785 chromatin;GO:0000796 condensin complex", "go_biological_process": "GO:0051301 cell division;GO:0007076 mitotic chromosome condensation;GO:0030261 chromosome condensation;GO:0000070 mitotic sister chromatid segregation;GO:0070550 rDNA chromatin condensation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38989-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39013-1", "uniprot_id": [ { "id": "END3_YEAST", "url": "https://www.uniprot.org/uniprot/P39013", "type": "external" } ], "mass": 40297.0, "length": 349, "protein_name": "Actin cytoskeleton-regulatory complex protein END3", "gene_name": "END3", "organism": "Yeast", "refseq_name": "End3p", "refseq_ac": [ { "id": "NP_014315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014315", "type": "external" } ], "gene_names_uniprotkb": "END3; N2307", "gene_names_refseq": "END3", "protein_names_uniprotkb": "Actin cytoskeleton-regulatory complex protein END3; Endocytosis protein 3", "protein_names_refseq": "End3p", "tax_id": 559292, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (sce:YNL084C)", "pathway_count": 1, "publication_count": 41, "publication_id_list": "10594004;10954428;10972812;11739778;11907579;11940605;14562095;14562106;15248838;15944351;16273108;16914733;17151356;17330950;17898076;18298676;18407956;19779198;20702584;21126336;22218487;23749301;24374639;32597660;33481703;33491328;7841519;7852314;7865884;8144575;8380177;8740422;8741841;8991091;9128251;9169873;9234686;9243513;9436999;9822599;9885245", "class_list": "", "function": "Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization. END3 regulates PAN1 function by preventing phosphorylation of PAN1 by PKR1 and is also involved in the correct localization of SLA1 to the cell cortex, in the bipolar budding of diploid cells and the correct distribution of chitin at the cell surface., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W195;Q8TFC4;Q8TFD0;Q8TG51", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0010008 endosome membrane;GO:0071944 cell periphery;GO:0030479 actin cortical patch", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0016197 endosomal transport;GO:0061709 reticulophagy;GO:0030476 ascospore wall assembly", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "P39013-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39014-1", "uniprot_id": [ { "id": "MET30_YEAST", "url": "https://www.uniprot.org/uniprot/P39014", "type": "external" } ], "mass": 72835.0, "length": 640, "protein_name": "F-box protein MET30", "gene_name": "MET30", "organism": "Yeast", "refseq_name": "ubiquitin-binding SDF ubiquitin ligase complex subunit MET30", "refseq_ac": [ { "id": "NP_012218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012218", "type": "external" } ], "gene_names_uniprotkb": "MET30", "gene_names_refseq": "MET30; ZRG11", "protein_names_uniprotkb": "F-box protein MET30; E3 ubiquitin ligase complex SCF(Met30) subunit MET30; Methionine-requiring protein 30", "protein_names_refseq": "ubiquitin-binding SDF ubiquitin ligase complex subunit MET30", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL046W)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10637232;11027256;14562095;14562106;14660673;15689486;15870262;15883825;17330950;18407956;19779198;20702584;21126336;23749301;24374639;24648496;32597660;33443148;33481703;33491328;8524217;9169870;9499404;9716410", "class_list": "", "function": "Substrate-recognition component of the SCF(Met30) complex, an E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10637232, PubMed:14660673, PubMed:9716410). Negatively regulates sulfur amino acids biosynthesis genes expression (PubMed:15689486, PubMed:15870262, PubMed:8524217). Controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the SCF(Met30) complex (PubMed:15689486, PubMed:15870262, PubMed:8524217). Required for the efficient binding of CDC45 and MCM proteins to origins of replication (PubMed:15689486, PubMed:15870262, PubMed:8524217). Required for efficient expression of G1 cyclins (PubMed:15870262). The SCF(Met30) complex catalyzes ubiquitination and degradation of the Cdk-inhibitory kinase SWE1 (PubMed:9716410). Involved in the S-adenosylmethionine (AdoMet)-mediated inhibition of the transcription function of MET4 (PubMed:10637232, PubMed:8524217). The SCF(Met30) complex mediates ubiquitination and subsequent degradation of MET4 and the cellular response to cadmium (PubMed:10637232). The SCF(Met30) complex acts as an inhibitor of autophagy by promoting ubiquitination and degradation of ATG9 in normal conditions (PubMed:33443148)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVN6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0043130 ubiquitin binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0140299 molecular sensor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex;GO:0043224 nuclear SCF ubiquitin ligase complex", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007346 regulation of mitotic cell cycle;GO:0046686 response to cadmium ion", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P39014-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39015-1", "uniprot_id": [ { "id": "STM1_YEAST", "url": "https://www.uniprot.org/uniprot/P39015", "type": "external" } ], "mass": 29995.0, "length": 273, "protein_name": "Suppressor protein STM1", "gene_name": "STM1", "organism": "Yeast", "refseq_name": "Stm1p", "refseq_ac": [ { "id": "NP_013251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013251", "type": "external" } ], "gene_names_uniprotkb": "STM1; L9634.1; MPT4; STO1", "gene_names_refseq": "MPT4; STM1", "protein_names_uniprotkb": "Suppressor protein STM1; 3BP1; AF; G4p2 protein; GU4 nucleic-binding protein 2; POP2 multicopy suppressor protein 4; Ribosomal subunits association factor; TOM1 suppressor protein 1; Triplex-binding protein 1", "protein_names_refseq": "Stm1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR150W); (R-SCE-114608)", "pathway_count": 2, "publication_count": 40, "publication_id_list": "10681538;11514626;12207228;14562106;15044472;15654430;16580682;17287358;17322287;17330950;17563356;18029617;18407956;19666721;19779198;19795423;19823750;20702584;21126336;21177495;21460238;22096102;22106047;22218487;23206692;23749301;24200810;24374639;25209664;29069440;30516470;32597660;33481703;33491328;34769086;36691768;7548221;7721866;9169871;9504907", "class_list": "", "function": "Ribosome preservation factor that protect a small pool of nontranslating, vacant ribosomes in cells under nutrient starvation conditions. Under nutrient-limiting conditions, cells reduce ribosome biogenesis and degrade ribosomes via autophagy (ribophagy) or proteasomal degradation. To avoid excessive degradation during starvation, STM1 binds to and protects 80S ribosomes from proteasomal degradation. Under nutrient-sufficient conditions, TORC1 phosphorylates and inhibits STM1 to prevent formation of dormant 80S ribosomes (PubMed:16580682, PubMed:19666721, PubMed:21460238, PubMed:23206692, PubMed:34769086, PubMed:36691768). Acts as an inhibitor of mRNA translation by promoting ribosome hibernation: clamps the two ribosomal subunits, thereby preventing their dissociation, and inhibits translation by excluding mRNA-binding (PubMed:19666721, PubMed:21460238, PubMed:22096102, PubMed:29069440, PubMed:36691768). Acts via its association with eEF2 (EFT1), promoting ribosome stabilization and storage in an inactive state (PubMed:23206692, PubMed:29069440). May also repress translation by preventing association of eEF3 (YEF3 and HEF3) with ribosomes (PubMed:19666721). Binds specifically G4 quadruplex (these are four-stranded right-handed helices, stabilized by guanine base quartets) and purine motif triplex (characterized by a third, antiparallel purine-rich DNA strand located within the major groove of a homopurine stretch of duplex DNA) nucleic acid structures. These structures may be present at telomeres or in rRNAs (PubMed:15044472). Acts with CDC13 to control telomere length homeostasis (PubMed:15044472). Involved in the control of the apoptosis-like cell death (PubMed:15044472)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 28, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYE5", "ec_number_list": [], "go_molecular_function": "GO:0045142 triplex DNA binding;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042162 telomeric DNA binding;GO:0030371 translation repressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0000723 telomere maintenance;GO:0031929 TOR signaling;GO:0006414 translational elongation;GO:0043558 regulation of translational initiation in response to stress", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "P39015-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39016-1", "uniprot_id": [ { "id": "MPT5_YEAST", "url": "https://www.uniprot.org/uniprot/P39016", "type": "external" } ], "mass": 95422.0, "length": 859, "protein_name": "Suppressor protein MPT5", "gene_name": "MPT5", "organism": "Yeast", "refseq_name": "Mpt5p", "refseq_ac": [ { "id": "NP_011337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011337", "type": "external" } ], "gene_names_uniprotkb": "MPT5; BIC834; HTR1; PUF5", "gene_names_refseq": "HTR1; MPT5; PUF5; UTH4", "protein_names_uniprotkb": "Suppressor protein MPT5; Protein HTR1; Pumilio homology domain family member 5", "protein_names_refseq": "Mpt5p", "tax_id": 559292, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YGL178W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10734188;11157761;14562106;15024427;17330950;17563356;18407956;19684113;19779198;23749301;24374639;32597660;33229814;33481703;33491328;7668046;7845352;9169869", "class_list": "", "function": "RNA-binding protein involved in post-transcriptional regulation. Negatively regulates expression of HO by binding to the 3'-UTR of HO mRNA. Predominantly binds to mRNAs encoding chromatin modifiers and spindle pole body components. Recognizes and binds to 5'-TGTAA[CT]A[AT]TA-3' in the 3'-UTR of target mRNAs. Multicopy suppressor of POP2 mutation. Required for high temperature growth., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6VTX5", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0010608 post-transcriptional regulation of gene expression;GO:0017148 negative regulation of translation;GO:0045947 negative regulation of translational initiation;GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0008298 intracellular mRNA localization", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P39016-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39103-1", "uniprot_id": [ { "id": "COX14_YEAST", "url": "https://www.uniprot.org/uniprot/P39103", "type": "external" } ], "mass": 7959.0, "length": 70, "protein_name": "Cytochrome c oxidase assembly protein COX14", "gene_name": "COX14", "organism": "Yeast", "refseq_name": "Cox14p", "refseq_ac": [ { "id": "NP_013577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013577", "type": "external" } ], "gene_names_uniprotkb": "COX14; YM4987.06C", "gene_names_refseq": "COX14", "protein_names_uniprotkb": "Cytochrome c oxidase assembly protein COX14", "protein_names_refseq": "Cox14p", "tax_id": 559292, "disease": "", "pathway": " (sce:YML129C)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14562106;24374639;7797555;9169872", "class_list": "", "function": "Required for the synthesis of yeast cytochrome oxidase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0F6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0050821 protein stabilization;GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0070130 negative regulation of mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P39103-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39111-1", "uniprot_id": [ { "id": "VATF_YEAST", "url": "https://www.uniprot.org/uniprot/P39111", "type": "external" } ], "mass": 13461.0, "length": 118, "protein_name": "V-type proton ATPase subunit F", "gene_name": "VMA7", "organism": "Yeast", "refseq_name": "H(+)-transporting V1 sector ATPase subunit F", "refseq_ac": [ { "id": "NP_011534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011534", "type": "external" } ], "gene_names_uniprotkb": "VMA7", "gene_names_refseq": "VMA7", "protein_names_uniprotkb": "V-type proton ATPase subunit F; V-ATPase 14 kDa subunit; V-ATPase subunit F; Vacuolar proton pump subunit F", "protein_names_refseq": "H(+)-transporting V1 sector ATPase subunit F", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR020C); (R-SCE-1222556); (R-SCE-77387); (R-SCE-917977); (R-SCE-9639288)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "14562106;18055462;24374639;25971514;27295975;33481703;33491328;7929071;7929308;9169869;9290212", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:7929071). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:7929071)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUF5", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane;GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0048388 endosomal lumen acidification;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport;GO:0061795 Golgi lumen acidification", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P39111-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39683-1", "uniprot_id": [ { "id": "NPT1_YEAST", "url": "https://www.uniprot.org/uniprot/P39683", "type": "external" } ], "mass": 49019.0, "length": 429, "protein_name": "Nicotinate phosphoribosyltransferase", "gene_name": "NPT1", "organism": "Yeast", "refseq_name": "nicotinate phosphoribosyltransferase", "refseq_ac": [ { "id": "NP_014852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014852", "type": "external" } ], "gene_names_uniprotkb": "NPT1", "gene_names_refseq": "NPT1", "protein_names_uniprotkb": "Nicotinate phosphoribosyltransferase; 6.3.4.21; NAPRTase", "protein_names_refseq": "nicotinate phosphoribosyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR209C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12062417;14562095;14562106;16154095;19779198;19795423;19823750;21177495;24374639;32597660;33481703;33491328;8516295;9169874;9521740", "class_list": "", "function": "Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:9521740). Essential for growth under anaerobic conditions (PubMed:12062417)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2R5;Q08626", "ec_number_list": [ { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" } ], "go_molecular_function": "GO:0016740 transferase activity;GO:0004516 nicotinate phosphoribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0000183 rDNA heterochromatin formation;GO:0019358 nicotinate nucleotide salvage;GO:0034355 NAD+ biosynthetic process via the salvage pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P39683-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39704-1", "uniprot_id": [ { "id": "ERP2_YEAST", "url": "https://www.uniprot.org/uniprot/P39704", "type": "external" } ], "mass": 24064.0, "length": 215, "protein_name": "Protein ERP2", "gene_name": "ERP2", "organism": "Yeast", "refseq_name": "Erp2p", "refseq_ac": [ { "id": "NP_009395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009395", "type": "external" } ], "gene_names_uniprotkb": "ERP2; FUN54", "gene_names_refseq": "ERP2", "protein_names_uniprotkb": "Protein ERP2", "protein_names_refseq": "Erp2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL007C); (R-SCE-6807878); (R-SCE-6811434)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10359606;14562106;16847258;17322287;24374639;7731988;7941740", "class_list": "", "function": "Involved in vesicular protein trafficking., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPL1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005798 Golgi-associated vesicle;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006900 vesicle budding from membrane;GO:0007030 Golgi organization;GO:0006621 protein retention in ER lumen", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P39704-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39705-1", "uniprot_id": [ { "id": "NUP60_YEAST", "url": "https://www.uniprot.org/uniprot/P39705", "type": "external" } ], "mass": 59039.0, "length": 539, "protein_name": "Nucleoporin NUP60", "gene_name": "NUP60", "organism": "Yeast", "refseq_name": "FG-nucleoporin NUP60", "refseq_ac": [ { "id": "NP_009401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009401", "type": "external" } ], "gene_names_uniprotkb": "NUP60; FUN17", "gene_names_refseq": "NUP60", "protein_names_uniprotkb": "Nucleoporin NUP60; Nuclear pore protein NUP60", "protein_names_refseq": "FG-nucleoporin NUP60", "tax_id": 559292, "disease": "", "pathway": " (sce:YAR002W)", "pathway_count": 1, "publication_count": 33, "publication_id_list": "10684247;11387327;11535617;12604785;12791264;14562106;14574415;15039779;15665377;17287358;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20190278;20702584;21126336;21177495;22031224;22218487;23749301;24374639;30516470;32597660;33229814;33481703;33491328;7731988;7941740", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 22, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 22, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 22, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 76, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 21, "binding_glycan_count": 0, "secondary_ac_list": "D6VPL6", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005829 cytosol", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0006302 double-strand break repair;GO:0006611 protein export from nucleus;GO:0031990 mRNA export from nucleus in response to heat stress", "synthesized_glycan_count": 0, "hit_score": 5.7, "record_id": "P39705-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39718-1", "uniprot_id": [ { "id": "PEX22_YEAST", "url": "https://www.uniprot.org/uniprot/P39718", "type": "external" } ], "mass": 19877.0, "length": 180, "protein_name": "Ubiquitin-conjugating enzyme E2 enzyme activator PEX22", "gene_name": "PEX22", "organism": "Yeast", "refseq_name": "ubiquitin-protein transferase activating protein PEX22", "refseq_ac": [ { "id": "NP_009346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009346", "type": "external" } ], "gene_names_uniprotkb": "PEX22", "gene_names_refseq": "PEX22; YAF5", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 enzyme activator PEX22; Peroxin-22; Peroxisome assembly protein 22", "protein_names_refseq": "ubiquitin-protein transferase activating protein PEX22", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL055W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10402463;14562106;17322287;17452527;22085930;23896733;24374639;7731988", "class_list": "", "function": "Assists in the ubiquitination of peroxisomal proteins by anchoring ubiquitin-conjugating enzyme E2 PEX4 to the peroxisomal membrane (PubMed:17452527, PubMed:22085930). Also stimulates PEX4 enzymatic activity (PubMed:22085930)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPG3", "ec_number_list": [], "go_molecular_function": "GO:0097027 ubiquitin-protein transferase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0031398 positive regulation of protein ubiquitination;GO:1902499 positive regulation of protein autoubiquitination;GO:0016562 protein import into peroxisome matrix, receptor recycling", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P39718-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39732-1", "uniprot_id": [ { "id": "GIP4_YEAST", "url": "https://www.uniprot.org/uniprot/P39732", "type": "external" } ], "mass": 86636.0, "length": 760, "protein_name": "GLC7-interacting protein 4", "gene_name": "GIP4", "organism": "Yeast", "refseq_name": "protein phosphatase regulator GIP4", "refseq_ac": [ { "id": "NP_009371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009371", "type": "external" } ], "gene_names_uniprotkb": "GIP4; FUN21", "gene_names_refseq": "FUN21; GIP4", "protein_names_uniprotkb": "GLC7-interacting protein 4", "protein_names_refseq": "protein phosphatase regulator GIP4", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL031C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "14562095;14562106;1583694;16537909;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;32597660;33481703;33491328;7731988", "class_list": "", "function": "GLC7 phosphatase-regulatory protein involved in GLC7 subcellular redistribution and chromosome segregation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 37, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VPI7", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0008157 protein phosphatase 1 binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P39732-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39904-1", "uniprot_id": [ { "id": "VPS52_YEAST", "url": "https://www.uniprot.org/uniprot/P39904", "type": "external" } ], "mass": 74333.0, "length": 641, "protein_name": "Vacuolar protein sorting-associated protein 52", "gene_name": "VPS52", "organism": "Yeast", "refseq_name": "Vps52p", "refseq_ac": [ { "id": "NP_010772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010772", "type": "external" } ], "gene_names_uniprotkb": "VPS52; D8035.27; SAC2", "gene_names_refseq": "SAC2; VPS52", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 52; Suppressor of actin mutation protein 2", "protein_names_refseq": "Vps52p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR484W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10637310;11689439;12377769;12446664;12686613;14562095;14562106;18407956;24374639;2656401;33491328;7754710;9169867", "class_list": "", "function": "Involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE TGL1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles. May also be involved in the actin cytoskeleton organization., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTA7;Q03379", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding", "go_cellular_component": "GO:0000938 GARP complex;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0010008 endosome membrane", "go_biological_process": "GO:0016239 positive regulation of macroautophagy;GO:0042147 retrograde transport, endosome to Golgi;GO:0032456 endocytic recycling;GO:0090156 intracellular sphingolipid homeostasis;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P39904-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39929-1", "uniprot_id": [ { "id": "SNF7_YEAST", "url": "https://www.uniprot.org/uniprot/P39929", "type": "external" } ], "mass": 26987.0, "length": 240, "protein_name": "Vacuolar-sorting protein SNF7", "gene_name": "SNF7", "organism": "Yeast", "refseq_name": "ESCRT-III subunit protein SNF7", "refseq_ac": [ { "id": "NP_013125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013125", "type": "external" } ], "gene_names_uniprotkb": "SNF7; DID1; VPS32", "gene_names_refseq": "DID1; RNS4; SNF7; VPL5; VPS32", "protein_names_uniprotkb": "Vacuolar-sorting protein SNF7; DOA4-independent degradation protein 1; Sucrose nonfermenting protein 7; Vacuolar protein-sorting-associated protein 32", "protein_names_refseq": "ESCRT-III subunit protein SNF7", "tax_id": 559292, "disease": "cataract 31 multiple types (Disease Ontology:DOID:0110265)", "pathway": " (sce:YLR025W); (R-SCE-1632852); (R-SCE-917729); (R-SCE-9668328)", "pathway_count": 4, "publication_count": 35, "publication_id_list": "11029042;11559748;12194857;14562106;15086794;15935782;16601096;17287358;17322287;17330950;1752413;17563356;18407956;18854142;19779198;19795423;19823750;21126336;21177495;22106047;23749301;24058170;24139821;24374639;24711499;25303532;26427873;26522593;26670543;30516470;3062374;33481703;33491328;8224817;9169871", "class_list": "", "function": "Acts a component of the ESCRT-III complex required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB) (PubMed:11559748, PubMed:12194857). The sequential action of ESCRT-0, -I, and -II together with the ordered assembly of ESCRT-III links membrane invagination to cargo sorting (PubMed:12194857). Membrane scission in the neck of the growing vesicle releases mature, cargo-laden ILVs into the lumen (PubMed:24139821, PubMed:24711499). ESCRT-III is critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment of late-acting components of the sorting machinery (PubMed:24139821, PubMed:24711499). SNF7 is the most abundant ESCRT-III subunit which forms membrane-sculpting filaments with 30 Angstrom periodicity and a exposed cationic membrane-binding surface (PubMed:26670543). Its activation requires a prominent conformational rearrangement to expose protein-membrane and protein-protein interfaces (PubMed:26670543). SNF7 filaments then form spirals that could function as spiral springs (PubMed:26522593). The elastic expansion of compressed SNF7 spirals generates an area difference between the two sides of the membrane and thus curvature which could be the origin of membrane deformation leading eventually to fission (PubMed:26522593). SNF7 recruits BRO1, which in turn recruits DOA4, which deubiquitinates cargos before their enclosure within MVB vesicles (PubMed:11029042, PubMed:15935782). ESCRT-III is also recruited to the nuclear envelope (NE) by integral INM proteins to surveil and clear defective nuclear pore complex (NPC) assembly intermediates to ensure the fidelity of NPC assembly (PubMed:25303532)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 23, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY27;E9P8V6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0015031 protein transport;GO:0007031 peroxisome organization;GO:0006900 vesicle budding from membrane;GO:0061709 reticulophagy", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P39929-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39955-1", "uniprot_id": [ { "id": "SAPR1_YEAST", "url": "https://www.uniprot.org/uniprot/P39955", "type": "external" } ], "mass": 100332.0, "length": 897, "protein_name": "Microtubule severing ATPase SAP1", "gene_name": "SAP1", "organism": "Yeast", "refseq_name": "putative AAA family ATPase SAP1", "refseq_ac": [ { "id": "NP_010966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010966", "type": "external" } ], "gene_names_uniprotkb": "SAP1", "gene_names_refseq": "SAP1", "protein_names_uniprotkb": "Microtubule severing ATPase SAP1; 5.6.1.1; Protein SAP1; SIN1-associated protein", "protein_names_refseq": "putative AAA family ATPase SAP1", "tax_id": 559292, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); hereditary spastic paraplegia 4 (Disease Ontology:DOID:0110792); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (sce:YER047C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562106;17330950;18407956;19779198;21126336;23749301;24374639;31208443;32597660;33481703;33491328;8654588;9169868", "class_list": "", "function": "May function as an ATP-dependent microtubule severing protein., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLU8", "ec_number_list": [], "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0051013 microtubule severing", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P39955-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39969-1", "uniprot_id": [ { "id": "BOI2_YEAST", "url": "https://www.uniprot.org/uniprot/P39969", "type": "external" } ], "mass": 115688.0, "length": 1040, "protein_name": "BEM1-interacting protein 2", "gene_name": "BOI2", "organism": "Yeast", "refseq_name": "Boi2p", "refseq_ac": [ { "id": "NP_011039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011039", "type": "external" } ], "gene_names_uniprotkb": "BOI2; BEB1", "gene_names_refseq": "BEB1; BOI2", "protein_names_uniprotkb": "BEM1-interacting protein 2", "protein_names_refseq": "Boi2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YER114C)", "pathway_count": 1, "publication_count": 31, "publication_id_list": "11875433;12097146;14562106;15665377;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22218487;23749301;24374639;24909858;28904204;30516470;32597660;33002606;33229814;33481703;33491328;34965436;8666671;8666672;9169868", "class_list": "", "function": "Protein involved in bud formation (PubMed:8666671). Functions redundantly with BOI1 to promote the fusion of secretory vesicles with the plasma membrane at sites of polarized growth (PubMed:28904204, PubMed:8666672). Acts as an abscission inhibitor during cytokinesis in response to chromatin bridges (PubMed:28904204)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 17, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 17, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 17, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 81, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "D3DM20", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0055037 recycling endosome;GO:0005802 trans-Golgi network;GO:0030427 site of polarized growth", "go_biological_process": "GO:0000920 septum digestion after cytokinesis;GO:0007015 actin filament organization;GO:0007032 endosome organization;GO:0001881 receptor recycling;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "P39969-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40010-1", "uniprot_id": [ { "id": "NUG1_YEAST", "url": "https://www.uniprot.org/uniprot/P40010", "type": "external" } ], "mass": 57709.0, "length": 520, "protein_name": "Nuclear GTP-binding protein NUG1", "gene_name": "NUG1", "organism": "Yeast", "refseq_name": "RNA-binding GTPase NUG1", "refseq_ac": [ { "id": "NP_010921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010921", "type": "external" } ], "gene_names_uniprotkb": "NUG1", "gene_names_refseq": "NUG1", "protein_names_uniprotkb": "Nuclear GTP-binding protein NUG1; Nuclear GTPase 1", "protein_names_refseq": "RNA-binding GTPase NUG1", "tax_id": 559292, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YER006W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11583615;14562106;18407956;19779198;20190278;21126336;23749301;24374639;33481703;33491328;9169868", "class_list": "", "function": "GTPase required for 60S ribosomal subunit export to the cytoplasm., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLQ2", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0015031 protein transport;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P40010-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80667-1", "uniprot_id": [ { "id": "PEX13_YEAST", "url": "https://www.uniprot.org/uniprot/P80667", "type": "external" } ], "mass": 42706.0, "length": 386, "protein_name": "Peroxisomal membrane protein PEX13", "gene_name": "PEX13", "organism": "Yeast", "refseq_name": "peroxin PEX13", "refseq_ac": [ { "id": "NP_013292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013292", "type": "external" } ], "gene_names_uniprotkb": "PEX13; L9470.1; PAS20", "gene_names_refseq": "PAS20; PEX13", "protein_names_uniprotkb": "Peroxisomal membrane protein PEX13; Peroxin-13", "protein_names_refseq": "peroxin PEX13", "tax_id": 559292, "disease": "peroxisome biogenesis disorder 11A (Disease Ontology:DOID:0080485); Peroxisome biogenesis disorder 11B (Disease Ontology:DOID:0081439); peroxisomal disease (Disease Ontology:DOID:906)", "pathway": " (sce:YLR191W); (R-SCE-9033241); (R-SCE-9603798)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12453410;14562106;20154681;24374639;33491328;40739340;8858166;8858167;9169871", "class_list": "", "function": "Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor or the PEX7-PEX21 or PEX7-PEX18 receptor complex (PubMed:20154681, PubMed:8858167). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (PubMed:20154681). Mechanistically, PEX5 (or PEX7-PEX21) receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:20154681)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYJ4", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0016561 protein import into peroxisome matrix, translocation;GO:0016560 protein import into peroxisome matrix, docking", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P80667-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40014-1", "uniprot_id": [ { "id": "SPC25_YEAST", "url": "https://www.uniprot.org/uniprot/P40014", "type": "external" } ], "mass": 25244.0, "length": 221, "protein_name": "Kinetochore protein SPC25", "gene_name": "SPC25", "organism": "Yeast", "refseq_name": "kinetochore-associated Ndc80 complex subunit SPC25", "refseq_ac": [ { "id": "NP_010934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010934", "type": "external" } ], "gene_names_uniprotkb": "SPC25", "gene_names_refseq": "SPC25", "protein_names_uniprotkb": "Kinetochore protein SPC25", "protein_names_refseq": "kinetochore-associated Ndc80 complex subunit SPC25", "tax_id": 559292, "disease": "", "pathway": " (sce:YER018C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11179222;11266451;11952896;12514103;14562106;15371542;15809444;22814378;24374639;32597660;33491328;7754704;9169868", "class_list": "", "function": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLR6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031262 Ndc80 complex;GO:0005634 nucleus;GO:0000776 kinetochore;GO:0000940 outer kinetochore", "go_biological_process": "GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0098653 centromere clustering", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P40014-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40020-1", "uniprot_id": [ { "id": "FIR1_YEAST", "url": "https://www.uniprot.org/uniprot/P40020", "type": "external" } ], "mass": 98812.0, "length": 876, "protein_name": "Factor interacting with REF2", "gene_name": "FIR1", "organism": "Yeast", "refseq_name": "Fir1p", "refseq_ac": [ { "id": "NP_010949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010949", "type": "external" } ], "gene_names_uniprotkb": "FIR1; PIP1", "gene_names_refseq": "FIR1; PIP1", "protein_names_uniprotkb": "Factor interacting with REF2; PAP1-interacting protein; Polymerase-interacting protein 1", "protein_names_refseq": "Fir1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YER032W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12748633;14562095;14574415;15121841;17287358;19779198;20702584;21126336;21177495;22218487;23749301;24374639;32597660;33481703;33491328;9169868;9196079;9236779", "class_list": "", "function": "Involved in 3' mRNA processing. Positively regulates poly(A) synthesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 40, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DLT1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005935 cellular bud neck", "go_biological_process": "GO:0006397 mRNA processing;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P40020-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40061-1", "uniprot_id": [ { "id": "TSC11_YEAST", "url": "https://www.uniprot.org/uniprot/P40061", "type": "external" } ], "mass": 164368.0, "length": 1430, "protein_name": "Target of rapamycin complex 2 subunit TSC11", "gene_name": "TSC11", "organism": "Yeast", "refseq_name": "TORC2 complex subunit TSC11", "refseq_ac": [ { "id": "NP_011018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011018", "type": "external" } ], "gene_names_uniprotkb": "TSC11; AVO3", "gene_names_refseq": "AVO3; TSC11", "protein_names_uniprotkb": "Target of rapamycin complex 2 subunit TSC11; Adheres voraciously to TOR2 protein 3; TORC2 subunit TSC11; Temperature-sensitive CSG2 suppressor protein 11", "protein_names_refseq": "TORC2 complex subunit TSC11", "tax_id": 559292, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); colon cancer (Disease Ontology:DOID:219); breast ductal carcinoma (Disease Ontology:DOID:3007); gallbladder cancer (Disease Ontology:DOID:3121); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung small cell carcinoma (Disease Ontology:DOID:5409); hepatocellular carcinoma (Disease Ontology:DOID:684); tongue cancer (Disease Ontology:DOID:8649); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YER093C); (R-SCE-1257604); (R-SCE-389357); (R-SCE-5218920); (R-SCE-6804757); (R-SCE-9856530)", "pathway_count": 6, "publication_count": 21, "publication_id_list": "12408816;12631735;14562106;15809876;16002396;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;23749301;24374639;29170376;32597660;33481703;33491328;9169868", "class_list": "", "function": "Essential component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway. TSC11 may exert its functions through two distinct mechanisms, one mediated by AVO1 and the other mediated by AVO2 and SLM1., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 44, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DM00", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005774 vacuolar membrane;GO:0031932 TORC2 complex", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0030148 sphingolipid biosynthetic process;GO:0001558 regulation of cell growth;GO:0031929 TOR signaling;GO:0030950 establishment or maintenance of actin cytoskeleton polarity", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P40061-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40072-1", "uniprot_id": [ { "id": "SLX8_YEAST", "url": "https://www.uniprot.org/uniprot/P40072", "type": "external" } ], "mass": 30764.0, "length": 274, "protein_name": "E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8", "gene_name": "SLX8", "organism": "Yeast", "refseq_name": "SUMO-targeted ubiquitin ligase complex subunit SLX8", "refseq_ac": [ { "id": "NP_011041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011041", "type": "external" } ], "gene_names_uniprotkb": "SLX8", "gene_names_refseq": "SLX8", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8; 2.3.2.27; RING-type E3 ubiquitin transferase SLX8; Synthetic lethal of unknown function protein 8", "protein_names_refseq": "SUMO-targeted ubiquitin ligase complex subunit SLX8", "tax_id": 559292, "disease": "", "pathway": " (sce:YER116C)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "11139495;16325482;16387868;17330950;17591698;17669696;17728242;17848550;18032921;18407956;18499666;18562670;18948542;19684113;19779198;20702584;21177495;23749301;23785440;24374639;26906737;26960795;30479332;30516470;31015336;32597660;33481703;33491328;9169868", "class_list": "", "function": "Component of the SUMO-targeted ubiquitin ligase (STUbL) complex SLX5/SLX8 that mediates ubiquitination and subsequent desumoylation of sumoylated proteins and proteins containing SUMO-like domains for their degradation (PubMed:11139495, PubMed:16325482, PubMed:17669696, PubMed:17848550, PubMed:18032921, PubMed:18499666, PubMed:18948542, PubMed:31015336). The STUbL complex SLX5/SLX8 stimulates ubiquitin conjugating enzymes, including UBC1, UBC4, UBC5 and UBC13-MMS2, and mediates the proteolytic down-regulation of sumoylated proteins (PubMed:18032921). The STUbL complex SLX5/SLX8 is involved in ubiquitin-mediated degradation of histone variant CSE4, preventing mislocalization to euchromatin (PubMed:26960795). The complex plays an essential role in maintenance of chromosome stability and links SUMO-dependent ubiquitination to a centromere-specific function during mitosis (PubMed:23785440). The complex is involved in proteolysis of spindle positioning protein KAR9 and ensures correct spindle function by regulating levels of microtubule-associated proteins (PubMed:26906737). During replication, the complex helps to prevent DNA lesions via recombination and has a role in localizing the DNA damage protein DCD2 (PubMed:16325482, PubMed:17591698). The complex especially ubiquitinates the nuclease YEN1 and prevents persistent accumulation of a fraction of YEN1 associated with sites of activity in late G2/M and helps maintain the balance between pro- and anti-crossover pathways during homologous recombination (PubMed:30479332). It is also involved in ubiquitin-mediated degradation of DNA repair proteins RAD52 and RAD57 (PubMed:18032921). Finally, the complex is recruited to distinct genomic hotspots of non-H2B protein ubiquitination (ub-hotspots) by the sumoylated transcription factor-like protein EUC1 where it ubiquitinates EUC1 and presumably other targets (PubMed:31015336)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM22", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000776 kinetochore;GO:0033768 SUMO-targeted ubiquitin ligase complex", "go_biological_process": "GO:0006281 DNA repair;GO:0016925 protein sumoylation;GO:0000723 telomere maintenance;GO:0006974 DNA damage response;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P40072-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40095-1", "uniprot_id": [ { "id": "YEY8_YEAST", "url": "https://www.uniprot.org/uniprot/P40095", "type": "external" } ], "mass": 63712.0, "length": 573, "protein_name": "Uncharacterized protein YER158C", "gene_name": "", "organism": "Yeast", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_011085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011085", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein YER158C", "protein_names_refseq": "uncharacterized protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YER158C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;19756047;19779198;23749301;24374639;33481703;33491328;9169868", "class_list": "", "function": "", "predicted_glycosites": 9, "predicted_n_glycosites": 8, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "D3DM65", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "", "go_biological_process": "GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P40095-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40302-1", "uniprot_id": [ { "id": "PSA6_YEAST", "url": "https://www.uniprot.org/uniprot/P40302", "type": "external" } ], "mass": 25604.0, "length": 234, "protein_name": "Proteasome subunit alpha type-6", "gene_name": "PRE5", "organism": "Yeast", "refseq_name": "proteasome core particle subunit alpha 6", "refseq_ac": [ { "id": "NP_014045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014045", "type": "external" } ], "gene_names_uniprotkb": "PRE5; YM9924.06", "gene_names_refseq": "PRE5", "protein_names_uniprotkb": "Proteasome subunit alpha type-6; Macropain subunit PRE5; Multicatalytic endopeptidase complex subunit PRE5; Proteasome component PRE5; Proteinase YSCE subunit PRE5", "protein_names_refseq": "proteasome core particle subunit alpha 6", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YMR314W); (R-SCE-1236974); (R-SCE-1236978); (R-SCE-5668541); (R-SCE-5689880); (R-SCE-9907900); (R-SCE-9912633)", "pathway_count": 7, "publication_count": 23, "publication_id_list": "11062564;11081519;14562106;16531229;16608349;16793518;17322287;17330950;18407956;19779198;20227375;20486117;21126336;21177495;22106047;22927375;24374639;32597660;33481703;33491328;7918444;9087403;9169872", "class_list": "", "function": "The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0E1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0005634 nucleus;GO:0019773 proteasome core complex, alpha-subunit complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010499 proteasomal ubiquitin-independent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P40302-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40325-1", "uniprot_id": [ { "id": "HUA1_YEAST", "url": "https://www.uniprot.org/uniprot/P40325", "type": "external" } ], "mass": 22435.0, "length": 198, "protein_name": "Proline-rich protein HUA1", "gene_name": "HUA1", "organism": "Yeast", "refseq_name": "Hua1p", "refseq_ac": [ { "id": "NP_011784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011784", "type": "external" } ], "gene_names_uniprotkb": "HUA1", "gene_names_refseq": "HUA1", "protein_names_uniprotkb": "Proline-rich protein HUA1", "protein_names_refseq": "Hua1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR268C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11914276;12872131;14566057;17322287;22814378;24374639;7754704;9169869;9605509", "class_list": "", "function": "May be involved in assembly and disassembly of the actin cytoskeleton., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV46", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P40325-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40327-1", "uniprot_id": [ { "id": "PRS4_YEAST", "url": "https://www.uniprot.org/uniprot/P40327", "type": "external" } ], "mass": 48828.0, "length": 437, "protein_name": "26S proteasome regulatory subunit 4 homolog", "gene_name": "RPT2", "organism": "Yeast", "refseq_name": "proteasome regulatory particle base subunit RPT2", "refseq_ac": [ { "id": "NP_010277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010277", "type": "external" } ], "gene_names_uniprotkb": "RPT2; D2920; YHS4; YTA5", "gene_names_refseq": "RPT2; YHS4; YTA5", "protein_names_uniprotkb": "26S proteasome regulatory subunit 4 homolog; Tat-binding homolog 5", "protein_names_refseq": "proteasome regulatory particle base subunit RPT2", "tax_id": 559292, "disease": "neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss (Disease Ontology:DOID:0081324); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (sce:YDL007W); (R-SCE-1236978); (R-SCE-5668541); (R-SCE-5689880); (R-SCE-9907900)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "12504901;17330950;17563356;18407956;20486117;22106047;22927375;23749301;24374639;33481703;33491328;7721833;7754704;9169867", "class_list": "", "function": "The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). Has ATPase activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRY1", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0036402 proteasome-activating activity", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0070651 nonfunctional rRNA decay;GO:0043171 peptide catabolic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045732 positive regulation of protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P40327-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40339-1", "uniprot_id": [ { "id": "RFC4_YEAST", "url": "https://www.uniprot.org/uniprot/P40339", "type": "external" } ], "mass": 36149.0, "length": 323, "protein_name": "Replication factor C subunit 4", "gene_name": "RFC4", "organism": "Yeast", "refseq_name": "replication factor C subunit 4", "refseq_ac": [ { "id": "NP_014547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014547", "type": "external" } ], "gene_names_uniprotkb": "RFC4; O0923", "gene_names_refseq": "RFC4", "protein_names_uniprotkb": "Replication factor C subunit 4; Activator 1 37 kDa subunit; Replication factor C4", "protein_names_refseq": "replication factor C subunit 4", "tax_id": 559292, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (sce:YOL094C); (R-SCE-176187); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-69091)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "11389843;11486023;12604797;12665596;12912927;14562106;15201901;15964801;24374639;33481703;33491328;7651383;8063832;8533473;9169874", "class_list": "", "function": "Component of ATP-dependent clamp loader (RFC and RFC-like) complexes for DNA clamps, such as the POL30/PCNA homotrimer and the checkpoint clamp DDC1:MEC3:RAD17 complex. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Component of the replication factor C (RFC or activator 1) complex which loads POL30/PCNA and acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. Component of the RFC-like RAD24-RFC complex which loads the checkpoint clamp DDC1:MEC3:RAD17 complex and is involved in DNA repair pathways. Component of the RFC-like ELG1-RFC complex which appears to have a role in DNA replication, replication fork re-start, recombination and repair., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1X4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0031390 Ctf18 RFC-like complex;GO:0031391 Elg1 RFC-like complex;GO:0005663 DNA replication factor C complex", "go_biological_process": "GO:0006272 leading strand elongation;GO:0006281 DNA repair;GO:0000077 DNA damage checkpoint signaling;GO:0007064 mitotic sister chromatid cohesion;GO:0007062 sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P40339-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40348-1", "uniprot_id": [ { "id": "RFC2_YEAST", "url": "https://www.uniprot.org/uniprot/P40348", "type": "external" } ], "mass": 39742.0, "length": 353, "protein_name": "Replication factor C subunit 2", "gene_name": "RFC2", "organism": "Yeast", "refseq_name": "replication factor C subunit 2", "refseq_ac": [ { "id": "NP_012602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012602", "type": "external" } ], "gene_names_uniprotkb": "RFC2; J1808", "gene_names_refseq": "RFC2", "protein_names_uniprotkb": "Replication factor C subunit 2; Activator 1 41 kDa subunit; Replication factor C2", "protein_names_refseq": "replication factor C subunit 2", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR068W); (R-SCE-176187); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-69091)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "10660302;11389843;11486023;12604797;12665596;12912927;14562106;15201901;15964801;17322287;22814378;24374639;33491328;7651383;8202350;8641269;8840504", "class_list": "", "function": "Component of ATP-dependent clamp loader (RFC and RFC-like) complexes for DNA clamps, such as the POL30/PCNA homotrimer and the checkpoint clamp DDC1:MEC3:RAD17 complex. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Component of the replication factor C (RFC or activator 1) complex which loads POL30/PCNA and acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. Component of the RFC-like RAD24-RFC complex which loads the checkpoint clamp DDC1:MEC3:RAD17 complex and is involved in DNA repair pathways. Component of the RFC-like ELG1-RFC complex which appears to have a role in DNA replication, replication fork re-start, recombination and repair. RFC2 binds ATP and single-stranded DNA., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWN9;E9P8U1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031390 Ctf18 RFC-like complex;GO:0031391 Elg1 RFC-like complex;GO:0005663 DNA replication factor C complex;GO:0031389 Rad17 RFC-like complex", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0006272 leading strand elongation;GO:0006281 DNA repair;GO:0006298 mismatch repair;GO:0000077 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P40348-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40352-1", "uniprot_id": [ { "id": "RAD26_YEAST", "url": "https://www.uniprot.org/uniprot/P40352", "type": "external" } ], "mass": 124528.0, "length": 1085, "protein_name": "DNA repair and recombination protein RAD26", "gene_name": "RAD26", "organism": "Yeast", "refseq_name": "DNA-dependent ATPase RAD26", "refseq_ac": [ { "id": "NP_012569", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012569", "type": "external" } ], "gene_names_uniprotkb": "RAD26; GTA1085; J1606", "gene_names_refseq": "RAD26", "protein_names_uniprotkb": "DNA repair and recombination protein RAD26; 3.6.4.-; DNA-dependent ATPase RAD26", "protein_names_refseq": "DNA-dependent ATPase RAD26", "tax_id": 559292, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); UV-sensitive syndrome (Disease Ontology:DOID:0060240); colorectal carcinoma (Disease Ontology:DOID:0080199); primary ovarian insufficiency 11 (Disease Ontology:DOID:0080868); Cockayne syndrome B (Disease Ontology:DOID:0080908); cerebrooculofacioskeletal syndrome 1 (Disease Ontology:DOID:0080911); age related macular degeneration 5 (Disease Ontology:DOID:0110028); De Sanctis-Cacchione syndrome (Disease Ontology:DOID:0112158); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); polyneuropathy due to drug (Disease Ontology:DOID:14184); transient cerebral ischemia (Disease Ontology:DOID:224); larynx cancer (Disease Ontology:DOID:2596); Cockayne syndrome (Disease Ontology:DOID:2962); middle cerebral artery infarction (Disease Ontology:DOID:3525); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); macular degeneration (Disease Ontology:DOID:4448); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YJR035W); (R-SCE-6781823); (R-SCE-6782135); (R-SCE-6782210)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "18407956;19779198;19795423;19823750;19901073;20190278;23749301;24374639;33481703;33491328;7957102;8198589;8641269;8702468", "class_list": "", "function": "A DNA-dependent ATPase that plays a role in transcription-coupled repair (TCR) (Probable). Does not have detectable helicase activity; ATPase is more active with single-stranded (ss)DNA than double-stranded (ds)DNA (PubMed:8702468). RNA does not stimulate ATPase (PubMed:8702468)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWK8", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003678 DNA helicase activity;GO:0008094 ATP-dependent activity, acting on DNA", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response;GO:0006283 transcription-coupled nucleotide-excision repair;GO:0006289 nucleotide-excision repair;GO:0061635 regulation of protein complex stability", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P40352-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40357-1", "uniprot_id": [ { "id": "SEC9_YEAST", "url": "https://www.uniprot.org/uniprot/P40357", "type": "external" } ], "mass": 73624.0, "length": 651, "protein_name": "Protein transport protein SEC9", "gene_name": "SEC9", "organism": "Yeast", "refseq_name": "Sec9p", "refseq_ac": [ { "id": "NP_011523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011523", "type": "external" } ], "gene_names_uniprotkb": "SEC9; HSS7", "gene_names_refseq": "HSS7; SEC9", "protein_names_uniprotkb": "Protein transport protein SEC9", "protein_names_refseq": "Sec9p", "tax_id": 559292, "disease": "CEDNIK syndrome (Disease Ontology:DOID:0060337); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); epilepsy (Disease Ontology:DOID:1826); schizophrenia (Disease Ontology:DOID:5419); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YGR009C); (R-SCE-199992); (R-SCE-6798695); (R-SCE-8980692); (R-SCE-9013406)", "pathway_count": 5, "publication_count": 21, "publication_id_list": "10402465;15964280;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;23749301;24374639;30516470;32597660;33229814;33481703;33491328;7954793;9169869", "class_list": "", "function": "Component of a SNARE complex that may be the effector of SEC4 function in exocytosis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 14, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 14, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 14, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "D6VUE6", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031201 SNARE complex;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0048210 Golgi vesicle fusion to target membrane;GO:0006886 intracellular protein transport;GO:0006887 exocytosis;GO:0035493 SNARE complex assembly;GO:0006893 Golgi to plasma membrane transport", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P40357-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40452-1", "uniprot_id": [ { "id": "COA1_YEAST", "url": "https://www.uniprot.org/uniprot/P40452", "type": "external" } ], "mass": 22044.0, "length": 197, "protein_name": "Cytochrome c oxidase assembly factor 1", "gene_name": "COA1", "organism": "Yeast", "refseq_name": "Coa1p", "refseq_ac": [ { "id": "NP_012109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012109", "type": "external" } ], "gene_names_uniprotkb": "COA1; FMP35", "gene_names_refseq": "COA1", "protein_names_uniprotkb": "Cytochrome c oxidase assembly factor 1", "protein_names_refseq": "Coa1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL157C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;14576278;17882259;17882260;19684113;24374639;9169870", "class_list": "", "function": "Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane. Involved in a step coupling MSS51-dependent cotranslational insertion of COX1 to the addition of its heme A and copper B cofactors., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVC9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P40452-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40453-1", "uniprot_id": [ { "id": "UBP7_YEAST", "url": "https://www.uniprot.org/uniprot/P40453", "type": "external" } ], "mass": 123134.0, "length": 1071, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 7", "gene_name": "UBP7", "organism": "Yeast", "refseq_name": "ubiquitin-specific protease UBP7", "refseq_ac": [ { "id": "NP_012110", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012110", "type": "external" } ], "gene_names_uniprotkb": "UBP7", "gene_names_refseq": "UBP7", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 7; 3.4.19.12; Deubiquitinating enzyme 7; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7", "protein_names_refseq": "ubiquitin-specific protease UBP7", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL156W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562095;14562106;17079730;18407956;19779198;19795423;19823750;22031224;23749301;24374639;32597660;33481703;33491328;9169870", "class_list": "", "function": "Involved in the sorting of ubiquitinated cargo proteins at the multivesicular body (MVB)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VVD1", "ec_number_list": [], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P40453-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40457-1", "uniprot_id": [ { "id": "MLP2_YEAST", "url": "https://www.uniprot.org/uniprot/P40457", "type": "external" } ], "mass": 195141.0, "length": 1679, "protein_name": "Protein MLP2", "gene_name": "MLP2", "organism": "Yeast", "refseq_name": "Mlp2p", "refseq_ac": [ { "id": "NP_012117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012117", "type": "external" } ], "gene_names_uniprotkb": "MLP2", "gene_names_refseq": "MLP2", "protein_names_uniprotkb": "Protein MLP2; Myosin-like protein 2", "protein_names_refseq": "Mlp2p", "tax_id": 559292, "disease": "autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (sce:YIL149C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10085285;10617624;10638763;11862215;12490156;14562106;14718167;16027220;17330950;17563356;18407956;19779198;19795423;19823750;20489023;21126336;23749301;24152732;24374639;32597660;33229814;33481703;33491328;9169870", "class_list": "", "function": "Together with the closely related MLP1, involved in the structural and functional organization of perinuclear chromatin (PubMed:10638763). MLP1/MLP2 associate with the nuclear pore complex and form filamentous structures along the nuclear periphery (PubMed:10085285, PubMed:10617624, PubMed:24152732). Has a role in the localization of Esc1 to nucleolar regions (PubMed:24152732). Together with MLP1, mediates tethering of the some telomeres to the nuclear periphery, probably mediated by YKU70/YKU80 (HDF1/HDF2) heterodimer and show perinuclear location dependent silencing (PubMed:11862215). MLP1 and MLP2 are involved in telomere length regulation but not silencing or telomere anchoring (PubMed:12490156). Plays a role in the incorporation of components into the spindle pole body (PubMed:10617624, PubMed:14718167, PubMed:16027220). Involved in double-strand break repair, probably also mediated by the YKU70/YKU80 (HDF1/HDF2) heterodimer (PubMed:10638763, PubMed:14718167, PubMed:16027220)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 36, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VVD8", "ec_number_list": [], "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006406 mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0006355 regulation of DNA-templated transcription;GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P40457-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40460-1", "uniprot_id": [ { "id": "NDC80_YEAST", "url": "https://www.uniprot.org/uniprot/P40460", "type": "external" } ], "mass": 80487.0, "length": 691, "protein_name": "Kinetochore protein NDC80", "gene_name": "NDC80", "organism": "Yeast", "refseq_name": "kinetochore-associated Ndc80 complex subunit NDC80", "refseq_ac": [ { "id": "NP_012122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012122", "type": "external" } ], "gene_names_uniprotkb": "NDC80; HEC1; TID3", "gene_names_refseq": "HEC1; NDC80; TID3", "protein_names_uniprotkb": "Kinetochore protein NDC80; 80 kDa spindle component protein; Nuclear division cycle protein 80; Two-hybrid interaction with DMC1 protein 3", "protein_names_refseq": "kinetochore-associated Ndc80 complex subunit NDC80", "tax_id": 559292, "disease": "stomach cancer (Disease Ontology:DOID:10534); cancer (Disease Ontology:DOID:162); lung non-small cell carcinoma (Disease Ontology:DOID:3908); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YIL144W)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10409732;11179222;11266451;11952896;12386167;12408861;12514103;14562106;15371542;15809444;18407956;19300438;19779198;19822728;20489023;21126336;2229181;23749301;24374639;30516470;31919192;32597660;33481703;33491328;9169870;9335591;9585415", "class_list": "", "function": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVE3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0031262 Ndc80 complex;GO:0005634 nucleus;GO:0000776 kinetochore;GO:0000779 condensed chromosome, centromeric region;GO:0000940 outer kinetochore", "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0034501 protein localization to kinetochore;GO:1990758 mitotic sister chromatid biorientation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P40460-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40498-1", "uniprot_id": [ { "id": "UTP25_YEAST", "url": "https://www.uniprot.org/uniprot/P40498", "type": "external" } ], "mass": 83991.0, "length": 721, "protein_name": "U3 small nucleolar RNA-associated protein 25", "gene_name": "UTP25", "organism": "Yeast", "refseq_name": "rRNA-binding ribosome biosynthesis protein UTP25", "refseq_ac": [ { "id": "NP_012175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012175", "type": "external" } ], "gene_names_uniprotkb": "UTP25", "gene_names_refseq": "UTP25", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 25; U three protein 25; U3 snoRNA-associated protein 25", "protein_names_refseq": "rRNA-binding ribosome biosynthesis protein UTP25", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL091C); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "14562095;14562106;17563356;18407956;19779198;19795423;19823750;20702584;20884785;21941128;22218487;23749301;24374639;33481703;33491328;9169870", "class_list": "", "function": "DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVJ6", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:0034511 U3 snoRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P40498-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40506-1", "uniprot_id": [ { "id": "PPCS_YEAST", "url": "https://www.uniprot.org/uniprot/P40506", "type": "external" } ], "mass": 41867.0, "length": 365, "protein_name": "Phosphopantothenate--cysteine ligase CAB2", "gene_name": "CAB2", "organism": "Yeast", "refseq_name": "phosphopantothenate--cysteine ligase CAB2", "refseq_ac": [ { "id": "NP_012183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012183", "type": "external" } ], "gene_names_uniprotkb": "CAB2", "gene_names_refseq": "CAB2", "protein_names_uniprotkb": "Phosphopantothenate--cysteine ligase CAB2; 6.3.2.5; Coenzyme A biosynthesis protein 2; PPC synthetase; Phosphopantothenoylcysteine synthetase", "protein_names_refseq": "phosphopantothenate--cysteine ligase CAB2", "tax_id": 559292, "disease": "dilated cardiomyopathy 2C (Disease Ontology:DOID:0081159); neurodegenerative disease (Disease Ontology:DOID:1289); dilated cardiomyopathy (Disease Ontology:DOID:12930); cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YIL083C); (R-SCE-196783)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14562095;14562106;19266201;23749301;24374639;33491328;9169870", "class_list": "", "function": "Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVK3", "ec_number_list": [ { "id": "6.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.5", "type": "external" } ], "go_molecular_function": "GO:0004632 phosphopantothenate--cysteine ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990143 CoA-synthesizing protein complex", "go_biological_process": "GO:0015937 coenzyme A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P40506-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40515-1", "uniprot_id": [ { "id": "FIS1_YEAST", "url": "https://www.uniprot.org/uniprot/P40515", "type": "external" } ], "mass": 17733.0, "length": 155, "protein_name": "Mitochondrial fission 1 protein", "gene_name": "FIS1", "organism": "Yeast", "refseq_name": "Fis1p", "refseq_ac": [ { "id": "NP_012199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012199", "type": "external" } ], "gene_names_uniprotkb": "FIS1; MDV2", "gene_names_refseq": "FIS1; MDV2", "protein_names_uniprotkb": "Mitochondrial fission 1 protein; Mitochondrial division protein 2", "protein_names_refseq": "Fis1p", "tax_id": 559292, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); dental fluorosis (Disease Ontology:DOID:13711); acute kidney failure (Disease Ontology:DOID:3021); rhinitis (Disease Ontology:DOID:4483); myocardial infarction (Disease Ontology:DOID:5844); chronic kidney disease (Disease Ontology:DOID:784); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (sce:YIL065C); (R-SCE-9603798)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11038182;11038183;12163467;12514182;12679388;14517324;14562106;14576278;15809300;17322287;21177495;23530241;24374639;33491328;9169870", "class_list": "", "function": "Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation. Required for targeting MDV1 to the mitochondria. Regulates the assembly of DNM1 into punctate structures, in the mitochondrial tubules, promoting mitochondrial membrane constriction and/or division., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VVL9", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0016559 peroxisome fission;GO:0006915 apoptotic process;GO:0007031 peroxisome organization;GO:0000266 mitochondrial fission;GO:0090141 positive regulation of mitochondrial fission", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P40515-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40555-1", "uniprot_id": [ { "id": "PSMD9_YEAST", "url": "https://www.uniprot.org/uniprot/P40555", "type": "external" } ], "mass": 24846.0, "length": 220, "protein_name": "Probable 26S proteasome regulatory subunit p27", "gene_name": "NAS2", "organism": "Yeast", "refseq_name": "Nas2p", "refseq_ac": [ { "id": "NP_012259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012259", "type": "external" } ], "gene_names_uniprotkb": "NAS2", "gene_names_refseq": "NAS2", "protein_names_uniprotkb": "Probable 26S proteasome regulatory subunit p27; Proteasome non-ATPase subunit 2", "protein_names_refseq": "Nas2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL007C); (R-SCE-9907900)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14562106;17322287;19446322;22814378;24374639;9169870;9653651", "class_list": "", "function": "Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC). During the base subcomplex assembly is part of a NAS2:RPT4:RPT5 module; NAS2 is released during the further base assembly process., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVS3", "ec_number_list": [], "go_molecular_function": "GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070682 proteasome regulatory particle assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P40555-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40559-1", "uniprot_id": [ { "id": "INP51_YEAST", "url": "https://www.uniprot.org/uniprot/P40559", "type": "external" } ], "mass": 108430.0, "length": 946, "protein_name": "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51", "gene_name": "INP51", "organism": "Yeast", "refseq_name": "phosphoinositide 5-phosphatase INP51", "refseq_ac": [ { "id": "NP_012264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012264", "type": "external" } ], "gene_names_uniprotkb": "INP51; SJL1; YIA2C", "gene_names_refseq": "INP51; SJL1", "protein_names_uniprotkb": "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51; 3.1.3.36; Synaptojanin-like protein 1", "protein_names_refseq": "phosphoinositide 5-phosphatase INP51", "tax_id": 559292, "disease": "early-onset Parkinson's disease (Disease Ontology:DOID:0060894); Parkinson's disease 20 (Disease Ontology:DOID:0060898); developmental and epileptic encephalopathy 53 (Disease Ontology:DOID:0080464); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (sce:YIL002C); (R-SCE-1660499)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11311145;14562095;14562106;15265867;15689497;15691741;17452534;21126336;24374639;32597660;7762303;9169870;9265642;9560389;9788876", "class_list": "", "function": "Controls the cellular levels and subcellular distribution of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Does not utilize phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), nor phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in endocytosis and acts as a negative regulator of the Slm pathway which modulates polarized actin assembly and growth., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVS9", "ec_number_list": [ { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0030479 actin cortical patch", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P40559-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40561-1", "uniprot_id": [ { "id": "SGN1_YEAST", "url": "https://www.uniprot.org/uniprot/P40561", "type": "external" } ], "mass": 28954.0, "length": 250, "protein_name": "RNA-binding protein SGN1", "gene_name": "SGN1", "organism": "Yeast", "refseq_name": "Sgn1p", "refseq_ac": [ { "id": "NP_012266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012266", "type": "external" } ], "gene_names_uniprotkb": "SGN1; RBP29; YIB1C", "gene_names_refseq": "RBP1; RBP29; SGN1", "protein_names_uniprotkb": "RNA-binding protein SGN1", "protein_names_refseq": "Sgn1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YIR001C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10764794;14562106;19779198;19795423;19823750;21126336;21177495;23749301;24374639;33481703;33491328;7762303;9169870", "class_list": "", "function": "mRNA-binding protein that may play a role in modulating the expression of cytoplasmic mRNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVT1", "ec_number_list": [], "go_molecular_function": "GO:0008143 poly(A) binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0033621 nuclear mRNA surveillance of meiosis-specific transcripts", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P40561-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40573-1", "uniprot_id": [ { "id": "MET28_YEAST", "url": "https://www.uniprot.org/uniprot/P40573", "type": "external" } ], "mass": 21590.0, "length": 187, "protein_name": "Transcriptional activator of sulfur metabolism MET28", "gene_name": "MET28", "organism": "Yeast", "refseq_name": "Met28p", "refseq_ac": [ { "id": "NP_012282", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012282", "type": "external" } ], "gene_names_uniprotkb": "MET28", "gene_names_refseq": "MET28", "protein_names_uniprotkb": "Transcriptional activator of sulfur metabolism MET28; Methionine-requiring protein 28", "protein_names_refseq": "Met28p", "tax_id": 559292, "disease": "", "pathway": " (sce:YIR017C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562095;24374639;8665859;9169870;9171357;9799240", "class_list": "", "function": "Acts as an accessory factor in the activation of sulfur amino acids metabolism genes. Possesses no intrinsic transcription activation abilities. Binds to the MET16 promoter as a complex with MET4 and CBF1. Enhances the DNA-binding activity of CBF1., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVU7", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0089713 Cbf1-Met4-Met28 complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009086 methionine biosynthetic process;GO:0019344 cysteine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P40573-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40693-1", "uniprot_id": [ { "id": "RLP7_YEAST", "url": "https://www.uniprot.org/uniprot/P40693", "type": "external" } ], "mass": 36559.0, "length": 322, "protein_name": "Ribosome biogenesis protein RLP7", "gene_name": "RLP7", "organism": "Yeast", "refseq_name": "Rlp7p", "refseq_ac": [ { "id": "NP_014396", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014396", "type": "external" } ], "gene_names_uniprotkb": "RLP7; N2014; RPL7", "gene_names_refseq": "RLP7; RPL7", "protein_names_uniprotkb": "Ribosome biogenesis protein RLP7; Ribosomal protein L7-like", "protein_names_refseq": "Rlp7p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL002C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "11087857;14562106;17287358;17322287;17330950;18407956;19779198;19795423;19823750;20190278;21126336;22814378;23749301;24374639;27821475;32597660;33229814;33481703;33491328;7941739;7985421;8256515;8402262;9169873", "class_list": "", "function": "Involved in the biogenesis of the 60S ribosomal subunit. May act as a specificity factor that binds precursor rRNAs and tethers the enzymes that carry out the early 5' to 3' exonucleolytic reactions that generate the mature rRNAs., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W1H5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0042134 rRNA primary transcript binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000465 exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P40693-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40956-1", "uniprot_id": [ { "id": "GTS1_YEAST", "url": "https://www.uniprot.org/uniprot/P40956", "type": "external" } ], "mass": 44407.0, "length": 396, "protein_name": "Protein GTS1", "gene_name": "GTS1", "organism": "Yeast", "refseq_name": "Gts1p", "refseq_ac": [ { "id": "NP_011334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011334", "type": "external" } ], "gene_names_uniprotkb": "GTS1; LSR1", "gene_names_refseq": "FHT1; GTS1; LSR1", "protein_names_uniprotkb": "Protein GTS1; Protein LSR1", "protein_names_refseq": "Gts1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL181W)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "11875433;14562106;17287358;17330950;17563356;18407956;19684113;19779198;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33229814;33481703;33491328;8035831;9046087;9169869;9219336", "class_list": "", "function": "Appears to modulate the timing of budding to obtain an appropriate cell size independent of the DNA replication cycle. Transcription factor involved in both heat resistance and flocculation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VTX2", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030479 actin cortical patch;GO:0005935 cellular bud neck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006897 endocytosis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0010512 negative regulation of phosphatidylinositol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P40956-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40960-1", "uniprot_id": [ { "id": "PAC11_YEAST", "url": "https://www.uniprot.org/uniprot/P40960", "type": "external" } ], "mass": 60074.0, "length": 533, "protein_name": "WD repeat-containing protein PAC11", "gene_name": "PAC11", "organism": "Yeast", "refseq_name": "dynein intermediate chain", "refseq_ac": [ { "id": "NP_010776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010776", "type": "external" } ], "gene_names_uniprotkb": "PAC11", "gene_names_refseq": "PAC11", "protein_names_uniprotkb": "WD repeat-containing protein PAC11", "protein_names_refseq": "dynein intermediate chain", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR488C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11266443;14562106;17322287;24374639;9169867", "class_list": "", "function": "Required for viability in the absence of the kinesin-related CIN8 mitotic motor. May be a dynein intermediate chain., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTB1;Q03398", "ec_number_list": [], "go_molecular_function": "GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005881 cytoplasmic microtubule;GO:0005868 cytoplasmic dynein complex", "go_biological_process": "GO:0000132 establishment of mitotic spindle orientation;GO:0040001 establishment of mitotic spindle localization;GO:0010970 transport along microtubule;GO:0030473 nuclear migration along microtubule", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P40960-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40963-1", "uniprot_id": [ { "id": "SAS2_YEAST", "url": "https://www.uniprot.org/uniprot/P40963", "type": "external" } ], "mass": 39206.0, "length": 338, "protein_name": "Histone acetyltransferase SAS2", "gene_name": "SAS2", "organism": "Yeast", "refseq_name": "histone acetyltransferase", "refseq_ac": [ { "id": "NP_013846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_013846", "type": "external" } ], "gene_names_uniprotkb": "SAS2; ESO1; YM9553.03C", "gene_names_refseq": "KAT8; SAS2", "protein_names_uniprotkb": "Histone acetyltransferase SAS2; 2.3.1.48; Something about silencing protein 2", "protein_names_refseq": "histone acetyltransferase", "tax_id": 559292, "disease": "breast cancer (Disease Ontology:DOID:1612); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": " (sce:YMR127C); (R-SCE-2559586); (R-SCE-5693548); (R-SCE-5693565); (R-SCE-9018519)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "11731479;11731480;12626510;14562095;16079223;18407956;19795423;19823750;22020126;23749301;24374639;33491328;8782818;9093847;9169872", "class_list": "", "function": "Histone acetyltransferase (HAT) subunit of the SAS complex, a multiprotein complex that acetylates 'Lys-16' of histone H4 and 'Lys-14' of histone H3. The SAS complex is however unable to acetylate nucleosomal histones. The complex is involved in transcriptional silencing at telomeres and at HML locus. Also involved in rDNA silencing and G0 control., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZV0", "ec_number_list": [ { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004402 histone acetyltransferase activity;GO:0016407 acetyltransferase activity;GO:0046972 histone H4K16 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000785 chromatin;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0030466 silent mating-type cassette heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P40963-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40968-1", "uniprot_id": [ { "id": "PRP17_YEAST", "url": "https://www.uniprot.org/uniprot/P40968", "type": "external" } ], "mass": 52048.0, "length": 455, "protein_name": "Pre-mRNA-processing factor 17", "gene_name": "CDC40", "organism": "Yeast", "refseq_name": "Cdc40p", "refseq_ac": [ { "id": "NP_010652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010652", "type": "external" } ], "gene_names_uniprotkb": "CDC40; D9481.11; PRP17; SLU4; XRS2", "gene_names_refseq": "CDC40; PRP17; SLT15; SLU4", "protein_names_uniprotkb": "Pre-mRNA-processing factor 17; Cell division control protein 40", "protein_names_refseq": "Cdc40p", "tax_id": 559292, "disease": "pontocerebellar hypoplasia type 15 (Disease Ontology:DOID:0112326)", "pathway": " (sce:YDR364C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11884590;14562106;14690591;19779198;24374639;7753021;9169867", "class_list": "", "function": "May function in the second step of pre-mRNA splicing. Regulatory protein involved in replication and mitotic spindle formation and/or maintenance. Required for initiation and completion of S-phase and for initiation and completion of DNA replication. Might be required for the maintenance of microtubules. Essential only at elevated temperatures., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSZ3;Q06341", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0034399 nuclear periphery", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000350 generation of catalytic spliceosome for second transesterification step;GO:0000389 mRNA 3'-splice site recognition;GO:0000348 mRNA branch site recognition", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P40968-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41318-1", "uniprot_id": [ { "id": "LST8_YEAST", "url": "https://www.uniprot.org/uniprot/P41318", "type": "external" } ], "mass": 34034.0, "length": 303, "protein_name": "Target of rapamycin complex subunit LST8", "gene_name": "LST8", "organism": "Yeast", "refseq_name": "TOR complex subunit LST8", "refseq_ac": [ { "id": "NP_014392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014392", "type": "external" } ], "gene_names_uniprotkb": "LST8; N2005", "gene_names_refseq": "LST8", "protein_names_uniprotkb": "Target of rapamycin complex subunit LST8; Lethal with SEC13 protein 8; TORC subunit LST8", "protein_names_refseq": "TOR complex subunit LST8", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL006W); (R-SCE-1257604); (R-SCE-3371571); (R-SCE-389357); (R-SCE-5218920); (R-SCE-6804757); (R-SCE-9639288); (R-SCE-9856530)", "pathway_count": 8, "publication_count": 13, "publication_id_list": "11742997;12408816;12631735;12719473;14562106;16002396;24374639;29170376;29698392;33491328;7985421;9169873;9409822", "class_list": "", "function": "Essential component of both TORC1 and TORC2. TORC1 regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. LST8 is involved in the negative regulation of transcription factors GLN3 and RTG1-RTG3, limiting the synthesis of alpha-ketoglutarate, glutamate and glutamine. LST8 is required for targeting of amino acid permeases (AAPs) to the plasma membrane. TORC2 regulates cell cycle-dependent polarization of the actin-cytoskeleton, cell wall integrity, and receptor endocytosis. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway. LST8 is involved in maintenance of cell wall integrity. LST8 modulates TOR2 kinase activity., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1H1", "ec_number_list": [], "go_molecular_function": "GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0010008 endosome membrane;GO:0005774 vacuolar membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007584 response to nutrient;GO:0032956 regulation of actin cytoskeleton organization;GO:0001558 regulation of cell growth;GO:0031929 TOR signaling", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P41318-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41543-1", "uniprot_id": [ { "id": "OST1_YEAST", "url": "https://www.uniprot.org/uniprot/P41543", "type": "external" } ], "mass": 54072.0, "length": 476, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "gene_name": "OST1", "organism": "Yeast", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1", "refseq_ac": [ { "id": "NP_012532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012532", "type": "external" } ], "gene_names_uniprotkb": "OST1; J1404; NLT1", "gene_names_refseq": "NLT1; OST1", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; N-linked oligosaccharyl transferase subunit 1; Oligosaccharyl transferase 64 kDa subunit; Oligosaccharyl transferase subunit OST1; Oligosaccharyl transferase subunit alpha", "protein_names_refseq": "dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL002C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11580295;14562095;14562106;15831493;15886282;16096345;16096346;16297388;24374639;29301962;29466327;7720878;7860628;8175708;8181570;8641269;9405463;9878773", "class_list": "", "function": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6VWH3", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P41543-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41813-1", "uniprot_id": [ { "id": "FKH2_YEAST", "url": "https://www.uniprot.org/uniprot/P41813", "type": "external" } ], "mass": 94374.0, "length": 862, "protein_name": "Fork head protein homolog 2", "gene_name": "FKH2", "organism": "Yeast", "refseq_name": "forkhead family transcription factor FKH2", "refseq_ac": [ { "id": "NP_014331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014331", "type": "external" } ], "gene_names_uniprotkb": "FKH2; N2403; YNL2403C", "gene_names_refseq": "FKH2", "protein_names_uniprotkb": "Fork head protein homolog 2", "protein_names_refseq": "forkhead family transcription factor FKH2", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL068C)", "pathway_count": 1, "publication_count": 33, "publication_id_list": "10747051;10894548;10894549;10959837;11562353;12702877;12865300;14562106;15509804;17283050;17287358;17563356;18407956;19779198;19795423;19823750;20702584;21177495;22265405;22438832;22932476;23749301;24374639;24504085;26728715;28649434;30516470;32597660;33481703;33491328;8533472;8701611;9169873", "class_list": "", "function": "Transcription factor that regulates the expression of the CLB2 cluster of genes during the G2/M phase of the mitotic cell cycle (PubMed:10894548, PubMed:10894549, PubMed:10959837, PubMed:11562353, PubMed:12702877, PubMed:17283050, PubMed:24504085). The CLB2 cluster of genes includes mitotic regulators such as CLB1, CLB2, CDC5 and CDC20 as well as SWI5 and ACE2, transcription factors required for the subsequent temporal wave of cell cycle regulated gene expression in the M/G1 phase interval (PubMed:10894548, PubMed:10959837, PubMed:11562353). Involved in HMRa silencing (PubMed:10747051). FKH1 and FKH2 associate with the coding regions of active genes and influence, in opposing ways, transcriptional elongation and termination, and coordinate early transcription elongation and pre-mRNA processing (PubMed:12702877). Both FKH1 and FKH2 play a role as regulators of lifespan in collaboration with the anaphase-promoting complex (APC), likely through combined regulation of stress response, genomic stability, and cell cycle regulation (PubMed:22438832). FKH1 and FKH2 function also in controlling yeast cell morphology by preventing preudohyphal growth (PubMed:10747051, PubMed:10894548). Acts as a rate-limiting replication origin activator via its interaction with the origin recognition complex (ORC) (PubMed:22265405, PubMed:26728715)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 40, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1B1", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P41813-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41818-1", "uniprot_id": [ { "id": "GLC8_YEAST", "url": "https://www.uniprot.org/uniprot/P41818", "type": "external" } ], "mass": 26649.0, "length": 229, "protein_name": "Protein GLC8", "gene_name": "GLC8", "organism": "Yeast", "refseq_name": "PP1-complex regulatory subunit GLC8", "refseq_ac": [ { "id": "NP_014042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014042", "type": "external" } ], "gene_names_uniprotkb": "GLC8; YM9924.03C", "gene_names_refseq": "GLC8", "protein_names_uniprotkb": "Protein GLC8", "protein_names_refseq": "PP1-complex regulatory subunit GLC8", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR311C)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "12407105;14562106;15665377;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20489023;21126336;21177495;22218487;22814378;23749301;23894419;24374639;30516470;31512287;32597660;33481703;33491328;8150278;9169872", "class_list": "", "function": "Modulator of GLC7 type-1 protein phosphatase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0D8", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007059 chromosome segregation;GO:0035556 intracellular signal transduction;GO:0005978 glycogen biosynthetic process;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P41818-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41832-1", "uniprot_id": [ { "id": "BNI1_YEAST", "url": "https://www.uniprot.org/uniprot/P41832", "type": "external" } ], "mass": 219673.0, "length": 1953, "protein_name": "Protein BNI1", "gene_name": "BNI1", "organism": "Yeast", "refseq_name": "formin BNI1", "refseq_ac": [ { "id": "NP_014128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014128", "type": "external" } ], "gene_names_uniprotkb": "BNI1; N0646; PPF3; SHE5", "gene_names_refseq": "BNI1; PPF3; SHE5", "protein_names_uniprotkb": "Protein BNI1; Pointed projection formation protein 3; Sensitive to high expression protein 5; Synthetic lethal 39", "protein_names_refseq": "formin BNI1", "tax_id": 559292, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); autosomal dominant auditory neuropathy 1 (Disease Ontology:DOID:0060690); nephrotic syndrome type 24 (Disease Ontology:DOID:0061194); primary ovarian insufficiency 2A (Disease Ontology:DOID:0080858); autosomal dominant nonsyndromic deafness 1 (Disease Ontology:DOID:0110541); sensorineural hearing loss (Disease Ontology:DOID:10003); microcephaly (Disease Ontology:DOID:10907); congenital dyserythropoietic anemia (Disease Ontology:DOID:1338); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (sce:YNL271C)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "10085293;14561409;14562106;15006353;15635372;15665377;17330950;17563356;18407956;19220811;19779198;19795423;19823750;20702584;21126336;22218487;23749301;24374639;24909858;27821475;30516470;31699995;32597660;33229814;33481703;33491328;7941743;8740425;9169873", "class_list": "", "function": "Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and acts as a leaky capper, slowing both polymerization and depolymerization. Protects the growing actin fiber from tight capping proteins and so increases the time of elongation and the total amount of F-actin. May organize microtubules by mediating spindle positioning and movement in the budding process. Potential target of the RHO family members., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 18, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 18, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 18, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 81, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "D6W0S3;O13450", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0031267 small GTPase binding;GO:0005522 profilin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0032153 cell division site;GO:0000131 incipient cellular bud site", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0051016 barbed-end actin filament capping;GO:0051017 actin filament bundle assembly;GO:0032880 regulation of protein localization;GO:0045010 actin nucleation", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "P41832-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42073-1", "uniprot_id": [ { "id": "REF2_YEAST", "url": "https://www.uniprot.org/uniprot/P42073", "type": "external" } ], "mass": 59819.0, "length": 533, "protein_name": "RNA end formation protein 2", "gene_name": "REF2", "organism": "Yeast", "refseq_name": "RNA-processing protein REF2", "refseq_ac": [ { "id": "NP_010481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010481", "type": "external" } ], "gene_names_uniprotkb": "REF2; YD9346.06", "gene_names_refseq": "REF2", "protein_names_uniprotkb": "RNA end formation protein 2", "protein_names_refseq": "RNA-processing protein REF2", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR195W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12773397;12819204;14562106;15121841;17330950;18407956;19779198;19795423;19823750;23749301;24374639;32597660;33229814;33481703;33491328;7862160;9169867;9196079", "class_list": "", "function": "RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Negative regulator of poly(A) synthesis. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation. REF2 is required for 3'-end formation of snoRNAs., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6VSH8", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0031124 mRNA 3'-end processing;GO:0031126 sno(s)RNA 3'-end processing;GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled;GO:1901901 regulation of protein localization to cell division site involved in cytokinesis;GO:1903501 positive regulation of mitotic actomyosin contractile ring assembly", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P42073-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42837-1", "uniprot_id": [ { "id": "FIG4_YEAST", "url": "https://www.uniprot.org/uniprot/P42837", "type": "external" } ], "mass": 101746.0, "length": 879, "protein_name": "Polyphosphoinositide phosphatase", "gene_name": "FIG4", "organism": "Yeast", "refseq_name": "phosphatidylinositol-3,5-bisphosphate 5-phosphatase", "refseq_ac": [ { "id": "NP_014074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014074", "type": "external" } ], "gene_names_uniprotkb": "FIG4; N0330", "gene_names_refseq": "FIG4", "protein_names_uniprotkb": "Polyphosphoinositide phosphatase; 3.1.3.-; Factor-induced gene 4 protein; Phosphatidylinositol 3,5-bisphosphate 5-phosphatase", "protein_names_refseq": "phosphatidylinositol-3,5-bisphosphate 5-phosphatase", "tax_id": 559292, "disease": "amyotrophic lateral sclerosis type 11 (Disease Ontology:DOID:0060202); Yunis-Varon syndrome (Disease Ontology:DOID:0060589); bilateral parasagittal parieto-occipital polymicrogyria (Disease Ontology:DOID:0080923); Charcot-Marie-Tooth disease type 4J (Disease Ontology:DOID:0110184); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (sce:YNL325C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11950935;14528018;14562106;16492811;17572665;18407956;18653468;19037259;24374639;33491328;7645347;9169873", "class_list": "", "function": "The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Major enzyme required for hyperosmotic shock-induced turnover of PtdIns(3,5)P2 and requires VAC14 for this function. In vivo, mediates turnover of PtdIns(3,5)P2 at the vacuole membrane necessary for vacuolar size control. In vitro, catalyzes the removal of phosphate from the fifth hydroxyl of the myo-inositol ring of phosphatidylinositol 3,5-bisphosphate., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0M2", "ec_number_list": [ { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0034399 nuclear periphery;GO:0070772 PAS complex;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0046856 phosphatidylinositol dephosphorylation;GO:1903100 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process;GO:0010511 regulation of phosphatidylinositol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P42837-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42838-1", "uniprot_id": [ { "id": "LEM3_YEAST", "url": "https://www.uniprot.org/uniprot/P42838", "type": "external" } ], "mass": 47438.0, "length": 414, "protein_name": "Phospholipid-transporting ATPase accessory subunit LEM3", "gene_name": "LEM3", "organism": "Yeast", "refseq_name": "Lem3p", "refseq_ac": [ { "id": "NP_014076", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014076", "type": "external" } ], "gene_names_uniprotkb": "LEM3; BRE3; N0333; ROS3", "gene_names_refseq": "BRE3; LEM3; ROS3", "protein_names_uniprotkb": "Phospholipid-transporting ATPase accessory subunit LEM3; Alkylphosphocholine resistance protein LEM3; Brefeldin-A sensitivity protein 3; Ro-sensitive 3", "protein_names_refseq": "Lem3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL323W)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "12133835;12842877;14562106;17330950;17563356;18407956;19411703;19779198;19795423;19823750;20702584;21126336;22218487;22791719;22814378;23749301;24374639;30516470;32597660;33320091;33481703;33491328;35294892;7645347;9169873", "class_list": "", "function": "Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide, phosphatidylcholine, phosphatidylethanolamine, and small amounts of phosphatidylserine from the lumenal to the cytosolic leaflet of the cell membrane and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:12133835, PubMed:12842877, PubMed:22791719). Contributes to substrate binding and specificity of the P4-ATPase catalytic subunit (PubMed:33320091)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6W0M3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:1990531 phospholipid-translocating ATPase complex", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0045332 phospholipid translocation;GO:0044088 regulation of vacuole organization;GO:0140331 aminophospholipid translocation", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P42838-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42949-1", "uniprot_id": [ { "id": "TIM16_YEAST", "url": "https://www.uniprot.org/uniprot/P42949", "type": "external" } ], "mass": 16216.0, "length": 149, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM16", "gene_name": "PAM16", "organism": "Yeast", "refseq_name": "import motor complex subunit PAM16", "refseq_ac": [ { "id": "NP_012431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012431", "type": "external" } ], "gene_names_uniprotkb": "PAM16; J0822; TIM16", "gene_names_refseq": "MIA1; PAM16; TIM16", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM16; Presequence translocated-associated motor subunit PAM16", "protein_names_refseq": "import motor complex subunit PAM16", "tax_id": 559292, "disease": "spondylometaphyseal dysplasia Megarbane-Dagher-Melike type (Disease Ontology:DOID:0112304); osteochondrodysplasia (Disease Ontology:DOID:2256)", "pathway": " (sce:YJL104W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562106;14981506;14981507;15218029;16027163;16105940;16107694;17322287;23749301;24374639;33491328;7483851;8641269", "class_list": "", "function": "Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW80;Q6B2X3", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex;GO:0001405 PAM complex, Tim23 associated import motor", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P42949-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43535-1", "uniprot_id": [ { "id": "GCN20_YEAST", "url": "https://www.uniprot.org/uniprot/P43535", "type": "external" } ], "mass": 85027.0, "length": 752, "protein_name": "Protein GCN20", "gene_name": "GCN20", "organism": "Yeast", "refseq_name": "putative AAA family ATPase GCN20", "refseq_ac": [ { "id": "NP_116664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116664", "type": "external" } ], "gene_names_uniprotkb": "GCN20", "gene_names_refseq": "GCN20", "protein_names_uniprotkb": "Protein GCN20; General control non-derepressible protein 20", "protein_names_refseq": "putative AAA family ATPase GCN20", "tax_id": 559292, "disease": "", "pathway": " (sce:YFR009W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10733573;10775272;11101534;14562106;15722345;17322287;18407956;22814378;24374639;33491328;33743194;34965436;7621831;7670463;9234705", "class_list": "", "function": "Acts as a positive activator of the GCN2 protein kinase activity in response to in response to low amino acid, carbon, or purine availability (PubMed:10733573, PubMed:7621831). Component of the GCN1-GCN20 complex that forms a complex with GCN2 on translating ribosomes; during this process, GCN20 helps GCN1 to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of GCN2, and hence stimulating GCN2 kinase activity (PubMed:10775272, PubMed:15722345, PubMed:7621831, PubMed:9234705). Participates in gene-specific mRNA translation activation, such as the transcriptional activator GCN4, by promoting the GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/SUI2) on 'Ser-52', and hence allowing GCN4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:15722345)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTN9", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0043022 ribosome binding;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0043335 protein unfolding;GO:0042327 positive regulation of phosphorylation;GO:0006448 regulation of translational elongation;GO:0071264 positive regulation of translational initiation in response to starvation;GO:0071232 cellular response to histidine", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P43535-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43583-1", "uniprot_id": [ { "id": "BLM10_YEAST", "url": "https://www.uniprot.org/uniprot/P43583", "type": "external" } ], "mass": 245996.0, "length": 2143, "protein_name": "Proteasome activator BLM10", "gene_name": "BLM10", "organism": "Yeast", "refseq_name": "proteasome activator BLM10", "refseq_ac": [ { "id": "NP_116648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116648", "type": "external" } ], "gene_names_uniprotkb": "BLM10; BLM3; YFL006W", "gene_names_refseq": "BLM10; YFL006W", "protein_names_uniprotkb": "Proteasome activator BLM10; Bleomycin resistance protein BLM10", "protein_names_refseq": "proteasome activator BLM10", "tax_id": 559292, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545)", "pathway": " (sce:YFL007W)", "pathway_count": 1, "publication_count": 38, "publication_id_list": "11842813;11875433;12185839;12748633;12973301;14562095;14562106;15449308;15665377;15778719;16952374;17287358;17322287;17330950;17563356;18407956;18927584;19684113;19779198;19795423;19823750;20227375;20486117;20702584;21126336;21177495;22025621;23273919;23706739;23749301;24374639;30516470;32597660;33481703;33491328;34965436;7670463;8789262", "class_list": "", "function": "Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Involved in DNA damage response in somatic cells: binds to acetylated histones and promotes degradation of histones following DNA double-strand breaks., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTM3;P43584", "ec_number_list": [], "go_molecular_function": "GO:0016504 peptidase activator activity;GO:0070628 proteasome binding", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0005634 nucleus", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0043248 proteasome assembly;GO:0061136 regulation of proteasomal protein catabolic process;GO:0010499 proteasomal ubiquitin-independent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P43583-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43587-1", "uniprot_id": [ { "id": "YPI1_YEAST", "url": "https://www.uniprot.org/uniprot/P43587", "type": "external" } ], "mass": 18187.0, "length": 155, "protein_name": "Type 1 phosphatases regulator YPI1", "gene_name": "YPI1", "organism": "Yeast", "refseq_name": "type 1 protein phosphatase-activating protein YPI1", "refseq_ac": [ { "id": "NP_116658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116658", "type": "external" } ], "gene_names_uniprotkb": "YPI1", "gene_names_refseq": "YPI1", "protein_names_uniprotkb": "Type 1 phosphatases regulator YPI1", "protein_names_refseq": "type 1 protein phosphatase-activating protein YPI1", "tax_id": 559292, "disease": "", "pathway": " (sce:YFR003C)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "14506263;14562106;14690591;15665377;16137619;17142459;17287358;17322287;17330950;17563356;18172024;18407956;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22218487;22814378;23749301;24374639;30516470;32597660;33481703;33491328;7670463", "class_list": "", "function": "Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control. Regulates the nuclear localization of type 1 phosphatase GLC7 and SDS22, and is involved in the regulation of mRNA 3'-end processing. May also regulate the activity of type 1 phosphatase PPZ1., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTN3", "ec_number_list": [], "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0008157 protein phosphatase 1 binding;GO:0072542 protein phosphatase activator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0006873 intracellular monoatomic ion homeostasis;GO:0051276 chromosome organization;GO:1900180 regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P43587-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43588-1", "uniprot_id": [ { "id": "RPN11_YEAST", "url": "https://www.uniprot.org/uniprot/P43588", "type": "external" } ], "mass": 34398.0, "length": 306, "protein_name": "Ubiquitin C-terminal hydrolase RPN11", "gene_name": "RPN11", "organism": "Yeast", "refseq_name": "proteasome regulatory particle lid subunit RPN11", "refseq_ac": [ { "id": "NP_116659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116659", "type": "external" } ], "gene_names_uniprotkb": "RPN11; MPR1", "gene_names_refseq": "MPR1; RPN11", "protein_names_uniprotkb": "Ubiquitin C-terminal hydrolase RPN11; 26S proteasome regulatory subunit RPN11; 3.4.19.12; Protein MPR1", "protein_names_refseq": "proteasome regulatory particle lid subunit RPN11", "tax_id": 559292, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658)", "pathway": " (sce:YFR004W); (R-SCE-1236978); (R-SCE-5668541); (R-SCE-5689880); (R-SCE-6798695); (R-SCE-9907900)", "pathway_count": 6, "publication_count": 16, "publication_id_list": "12183636;12504901;14562106;17322287;18407956;20486117;21075847;22927375;23589842;23911091;24374639;24463465;33481703;33491328;7628709;7670463", "class_list": "", "function": "Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. RPN11 is the only catalytically active member of the lid and serves as the essential deubiquitinase of the proteasome., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTN4;Q8J0T5", "ec_number_list": [ { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.4.23.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.25", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.7.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.59", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.3.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10", "type": "external" } ], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding;GO:0070628 proteasome binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0140492 metal-dependent deubiquitinase activity", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0008541 proteasome regulatory particle, lid subcomplex", "go_biological_process": "GO:0016559 peroxisome fission;GO:0016579 protein deubiquitination;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P43588-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43594-1", "uniprot_id": [ { "id": "MIC19_YEAST", "url": "https://www.uniprot.org/uniprot/P43594", "type": "external" } ], "mass": 18855.0, "length": 170, "protein_name": "MICOS complex subunit MIC19", "gene_name": "MIC19", "organism": "Yeast", "refseq_name": "Mic19p", "refseq_ac": [ { "id": "NP_116666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116666", "type": "external" } ], "gene_names_uniprotkb": "MIC19; AIM13; MCS19", "gene_names_refseq": "AIM13; MCS19; MIC19", "protein_names_uniprotkb": "MICOS complex subunit MIC19; Altered inheritance of mitochondria protein 13, mitochondrial; Mitochondrial contact site complex 19 kDa subunit", "protein_names_refseq": "Mic19p", "tax_id": 559292, "disease": "", "pathway": " (sce:YFR011C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562095;14562106;17322287;19300474;19779198;21944719;21987634;22009199;24374639;24687277;33481703;33491328;7670463", "class_list": "", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTP1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0044284 mitochondrial crista junction;GO:0061617 MICOS complex", "go_biological_process": "GO:0042407 cristae formation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P43594-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43596-1", "uniprot_id": [ { "id": "IOC3_YEAST", "url": "https://www.uniprot.org/uniprot/P43596", "type": "external" } ], "mass": 90897.0, "length": 787, "protein_name": "ISWI one complex protein 3", "gene_name": "IOC3", "organism": "Yeast", "refseq_name": "Ioc3p", "refseq_ac": [ { "id": "NP_116668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116668", "type": "external" } ], "gene_names_uniprotkb": "IOC3", "gene_names_refseq": "IOC3", "protein_names_uniprotkb": "ISWI one complex protein 3", "protein_names_refseq": "Ioc3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YFR013W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12482963;14562095;14562106;14622597;24374639;33481703;33491328;33502312;7670463", "class_list": "", "function": "Functions as a component of the ISW1A complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1A complex represses gene expression at initiation through specific positioning of a promoter proximal dinucleosome., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTP4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036436 Isw1a complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0007062 sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P43596-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43609-1", "uniprot_id": [ { "id": "RSC8_YEAST", "url": "https://www.uniprot.org/uniprot/P43609", "type": "external" } ], "mass": 63168.0, "length": 557, "protein_name": "Chromatin structure-remodeling complex protein RSC8", "gene_name": "RSC8", "organism": "Yeast", "refseq_name": "Rsc8p", "refseq_ac": [ { "id": "NP_116695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116695", "type": "external" } ], "gene_names_uniprotkb": "RSC8; SWH3", "gene_names_refseq": "RSC8; SWH3", "protein_names_uniprotkb": "Chromatin structure-remodeling complex protein RSC8; Remodel the structure of chromatin complex subunit 8; SWI3 homolog", "protein_names_refseq": "Rsc8p", "tax_id": 559292, "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340); colorectal carcinoma (Disease Ontology:DOID:0080199); Coffin-Siris syndrome 8 (Disease Ontology:DOID:0112367); hydrocephalus (Disease Ontology:DOID:10908); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); Coffin-Siris syndrome (Disease Ontology:DOID:1925); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YFR037C)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10025404;10329629;10619019;12072455;12183366;12419236;12684875;12697820;14562106;16204215;17322287;19779198;19795423;19823750;21126336;23749301;24374639;32597660;33481703;33491328;7670463;8686381;8980231;9121424;9685490", "class_list": "", "function": "Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and for repression of CHA1 expression., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTS0;Q6B289", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016514 SWI/SNF complex;GO:0000785 chromatin;GO:0016586 RSC-type complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P43609-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43618-1", "uniprot_id": [ { "id": "CENPT_YEAST", "url": "https://www.uniprot.org/uniprot/P43618", "type": "external" } ], "mass": 41313.0, "length": 361, "protein_name": "Inner kinetochore subunit CNN1", "gene_name": "CNN1", "organism": "Yeast", "refseq_name": "centromere-binding protein CNN1", "refseq_ac": [ { "id": "NP_116704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116704", "type": "external" } ], "gene_names_uniprotkb": "CNN1", "gene_names_refseq": "CNN1", "protein_names_uniprotkb": "Inner kinetochore subunit CNN1; CENP-T homolog; Co-purified with NNF1 protein 1; Constitutive centromere-associated network protein CNN1", "protein_names_refseq": "centromere-binding protein CNN1", "tax_id": 559292, "disease": "", "pathway": " (sce:YFR046C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562095;14562106;14633972;17322287;19779198;20489023;22561345;22561346;23334295;23749301;24374639;32997987;33481703;33491328;34308839;7670463;8686379", "class_list": "", "function": "Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (PubMed:22561346). Modulates outer kinetochore KMN network activity by regulating interactions within the network (PubMed:23334295, PubMed:22561345)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 29, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTS9;Q6B2K8", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0019237 centromeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore", "go_biological_process": "GO:0007059 chromosome segregation;GO:0051301 cell division;GO:1905560 negative regulation of kinetochore assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P43618-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43638-1", "uniprot_id": [ { "id": "MHP1_YEAST", "url": "https://www.uniprot.org/uniprot/P43638", "type": "external" } ], "mass": 155207.0, "length": 1398, "protein_name": "MAP-homologous protein 1", "gene_name": "MHP1", "organism": "Yeast", "refseq_name": "Mhp1p", "refseq_ac": [ { "id": "NP_012493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012493", "type": "external" } ], "gene_names_uniprotkb": "MHP1; J1206", "gene_names_refseq": "MHP1", "protein_names_uniprotkb": "MAP-homologous protein 1", "protein_names_refseq": "Mhp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL042W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "14562106;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;21126336;21177495;22106047;22814378;23749301;24374639;30516470;32597660;33481703;33491328;8641269;8947554", "class_list": "", "function": "Essential for the formation and/or stabilization of microtubules. Binds to microtubules in vitro., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 58, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VWE2", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005874 microtubule", "go_biological_process": "GO:0007026 negative regulation of microtubule depolymerization;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P43638-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P45976-1", "uniprot_id": [ { "id": "FIP1_YEAST", "url": "https://www.uniprot.org/uniprot/P45976", "type": "external" } ], "mass": 35777.0, "length": 327, "protein_name": "Pre-mRNA polyadenylation factor FIP1", "gene_name": "FIP1", "organism": "Yeast", "refseq_name": "cleavage polyadenylation factor subunit FIP1", "refseq_ac": [ { "id": "NP_012626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012626", "type": "external" } ], "gene_names_uniprotkb": "FIP1; J1911", "gene_names_refseq": "FIP1", "protein_names_uniprotkb": "Pre-mRNA polyadenylation factor FIP1", "protein_names_refseq": "cleavage polyadenylation factor subunit FIP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR093C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10619842;11238938;12626716;12819204;14562106;16496213;17563356;18407956;18537269;19779198;19795423;19823750;21177495;22218487;23749301;24374639;32597660;33481703;33491328;7736590;8641269", "class_list": "", "function": "Polymerase-regulating component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase PAP1. This inhibits the extension of an oligo(A) primer by limiting access of the RNA substrate to the C-terminal RNA binding domain of PAP1. Seems to tether PAP1 to the cleavage factor I., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWR1", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P45976-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46676-1", "uniprot_id": [ { "id": "SUM1_YEAST", "url": "https://www.uniprot.org/uniprot/P46676", "type": "external" } ], "mass": 118201.0, "length": 1062, "protein_name": "Suppressor of mar1-1 protein", "gene_name": "SUM1", "organism": "Yeast", "refseq_name": "Sum1p", "refseq_ac": [ { "id": "NP_010596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_010596", "type": "external" } ], "gene_names_uniprotkb": "SUM1; D9740.19", "gene_names_refseq": "SUM1", "protein_names_uniprotkb": "Suppressor of mar1-1 protein; SUM1-1 protein", "protein_names_refseq": "Sum1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR310C)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10562556;12612074;14562106;15665377;17198398;17330950;17563356;18407956;19528232;19684113;19779198;20190278;20702584;21126336;21177495;22106412;22814378;23749301;24374639;27821475;32597660;33229814;33481703;33491328;8754829;9169867", "class_list": "", "function": "DNA-binding protein that specifically binds the regulatory region of middle sporulation genes (MSE). Required for the repression of middle sporulation genes during vegetative growth. Represses expression via the recruitment of histone deacetylase HST1., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 18, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 18, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 18, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 81, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "D6VST9", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "P46676-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46946-1", "uniprot_id": [ { "id": "COM1_YEAST", "url": "https://www.uniprot.org/uniprot/P46946", "type": "external" } ], "mass": 40097.0, "length": 345, "protein_name": "DNA endonuclease SAE2", "gene_name": "SAE2", "organism": "Yeast", "refseq_name": "ssDNA endodeoxyribonuclease SAE2", "refseq_ac": [ { "id": "NP_011340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011340", "type": "external" } ], "gene_names_uniprotkb": "SAE2; COM1; G1639", "gene_names_refseq": "COM1; SAE2", "protein_names_uniprotkb": "DNA endonuclease SAE2; 3.1.-.-; Completion of meiotic recombination protein 1; Sporulation in the absence of SPO11 protein 2", "protein_names_refseq": "ssDNA endodeoxyribonuclease SAE2", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL175C)", "pathway_count": 1, "publication_count": 44, "publication_id_list": "11052944;11333222;11832209;11983174;12839620;12925751;14562095;14562106;14729978;15121837;15369670;15655113;15834151;15937224;16162495;16374511;16861895;17565964;17989249;18042458;18407956;18670132;18716619;18806779;19124276;19361851;19595717;19779198;20061370;20150422;22563681;23749301;24344201;24374639;24699249;25762720;30275497;31552432;33481703;33491328;8619317;9169869;9215887;9215888", "class_list": "", "function": "Endonuclease that cooperates with the MRX complex in processing meiotic and mitotic double-strand breaks by allowing the endonucleolytic removal of SPO11 from the break sites and ensuring both resection and intrachromosomal association of the broken ends. Required for proper recovery from checkpoint-mediated cell cycle arrest after DNA damage. MRX complex and SAE2 remove a small oligonucleotide(s) from the DNA ends to form an early intermediate which is rapidly processed by EXO1 and/or SGS1 to generate extensive tracts of single-stranded DNA that serve as substrate for RAD51. Plays a transitional role in the dissociation of MRE11 from, and the recruitment of RAD52 to, repair foci. Ensures that both ends of a DSB participate in a recombination event and impairs the formation of palindromic structures in the genome. With TEL1, promotes microhomology-mediated end joining (MMEJ) but inhibits non-homologous end joining (NHEJ), likely by regulating MRE11-dependent ssDNA accumulation at DNA break. SAE2 and MRX are particularly important for removal of hairpins, bulky adducts and other irregular end structures. Facilitates telomere length reequilibration and subsequent checkpoint switch off. Involved in homing efficiency of VMA1 intein VDE and in repair of transposon excision sites., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTX7", "ec_number_list": [ { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.2", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0042802 identical protein binding;GO:0003690 double-stranded DNA binding;GO:0004520 DNA endonuclease activity;GO:0170053 nuclease activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030870 Mre11 complex", "go_biological_process": "GO:0000723 telomere maintenance;GO:0042138 meiotic DNA double-strand break formation;GO:0006308 DNA catabolic process;GO:0000706 meiotic DNA double-strand break processing;GO:0000729 DNA double-strand break processing", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "P46946-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46951-1", "uniprot_id": [ { "id": "YPP1_YEAST", "url": "https://www.uniprot.org/uniprot/P46951", "type": "external" } ], "mass": 95366.0, "length": 817, "protein_name": "Cargo-transport protein YPP1", "gene_name": "YPP1", "organism": "Yeast", "refseq_name": "Ypp1p", "refseq_ac": [ { "id": "NP_011714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_011714", "type": "external" } ], "gene_names_uniprotkb": "YPP1; G7594", "gene_names_refseq": "YPP1", "protein_names_uniprotkb": "Cargo-transport protein YPP1; Alpha-synuclein protective protein 1", "protein_names_refseq": "Ypp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR198W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;14690591;16702403;17576801;19779198;24374639;7502584;9169869", "class_list": "", "function": "Involved in endocytosis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VUY0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006898 receptor-mediated endocytosis;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P46951-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46964-1", "uniprot_id": [ { "id": "OST2_YEAST", "url": "https://www.uniprot.org/uniprot/P46964", "type": "external" } ], "mass": 14698.0, "length": 130, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2", "gene_name": "OST2", "organism": "Yeast", "refseq_name": "dolichyl-diphosphooligosaccharide-protein glycotransferase", "refseq_ac": [ { "id": "NP_014746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_014746", "type": "external" } ], "gene_names_uniprotkb": "OST2; YOR3211C", "gene_names_refseq": "OST2", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2; Oligosaccharyl transferase 16 kDa subunit; Oligosaccharyl transferase subunit OST2; Oligosaccharyl transferase subunit epsilon", "protein_names_refseq": "dolichyl-diphosphooligosaccharide-protein glycotransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR103C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11580295;15831493;15886282;16096345;16096346;16297388;16847258;24374639;29301962;29466327;7593165;8175708;9169874;9200815;9405463;9878773", "class_list": "", "function": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2G3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex", "go_biological_process": "GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P46964-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000000010.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46985-1", "uniprot_id": [ { "id": "MNN11_YEAST", "url": "https://www.uniprot.org/uniprot/P46985", "type": "external" } ], "mass": 47859.0, "length": 422, "protein_name": "Probable alpha-1,6-mannosyltransferase MNN11", "gene_name": "MNN11", "organism": "Yeast", "refseq_name": "alpha-1,6-mannosyltransferase", "refseq_ac": [ { "id": "NP_012352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012352", "type": "external" } ], "gene_names_uniprotkb": "MNN11; J0425", "gene_names_refseq": "MNN11", "protein_names_uniprotkb": "Probable alpha-1,6-mannosyltransferase MNN11; 2.4.1.-; M-Pol II subunit MNN11; Mannan polymerase II complex MNN11 subunit", "protein_names_refseq": "alpha-1,6-mannosyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL183W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10037752;14562095;14562106;17322287;19795423;19823750;24374639;8641269;9430634", "class_list": "glycogene;glycosyltransferase", "function": "Required for synthesis of full-length mannan chains., [UniProtKB, PubMed]; The M-Pol II complex possesses alpha-1,6-mannosyltransferase activity and is probably involved in the elongation of the mannan backbone of N-linked glycans on cell wall and periplasmic proteins., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW07;E9P8Z0", "ec_number_list": [], "go_molecular_function": "GO:0000009 alpha-1,6-mannosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0000136 mannan polymerase complex", "go_biological_process": "GO:0000032 cell wall mannoprotein biosynthetic process;GO:0009101 glycoprotein biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P46985-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47037-1", "uniprot_id": [ { "id": "SMC3_YEAST", "url": "https://www.uniprot.org/uniprot/P47037", "type": "external" } ], "mass": 141336.0, "length": 1230, "protein_name": "Structural maintenance of chromosomes protein 3", "gene_name": "SMC3", "organism": "Yeast", "refseq_name": "cohesin subunit SMC3", "refseq_ac": [ { "id": "NP_012461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012461", "type": "external" } ], "gene_names_uniprotkb": "SMC3; J1049", "gene_names_refseq": "SMC3", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 3; DA-box protein SMC3", "protein_names_refseq": "cohesin subunit SMC3", "tax_id": 559292, "disease": "Cornelia de Lange syndrome 3 (Disease Ontology:DOID:0080507); intellectual disability (Disease Ontology:DOID:1059); Cornelia de Lange syndrome (Disease Ontology:DOID:11725); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YJL074C); (R-SCE-2468052); (R-SCE-2500257); (R-SCE-3108214)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "11983169;14562106;18614053;22031224;24374639;33491328;8641269;9335333;9990856", "class_list": "", "function": "Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWA9", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0030892 mitotic cohesin complex;GO:0005634 nucleus", "go_biological_process": "GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0007130 synaptonemal complex assembly;GO:0034087 establishment of mitotic sister chromatid cohesion;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P47037-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47041-1", "uniprot_id": [ { "id": "BIT61_YEAST", "url": "https://www.uniprot.org/uniprot/P47041", "type": "external" } ], "mass": 60841.0, "length": 543, "protein_name": "Target of rapamycin complex 2 subunit BIT61", "gene_name": "BIT61", "organism": "Yeast", "refseq_name": "Bit61p", "refseq_ac": [ { "id": "NP_012477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012477", "type": "external" } ], "gene_names_uniprotkb": "BIT61; J1141", "gene_names_refseq": "BIT61", "protein_names_uniprotkb": "Target of rapamycin complex 2 subunit BIT61; 61 kDa binding partner of TOR2 protein; TORC2 subunit BIT61", "protein_names_refseq": "Bit61p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL058C); (R-SCE-1257604); (R-SCE-389357); (R-SCE-5218920); (R-SCE-6804757); (R-SCE-9856530)", "pathway_count": 6, "publication_count": 21, "publication_id_list": "14562106;14736892;15689497;17322287;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21177495;23749301;24374639;24909858;29170376;30516470;32597660;33481703;33491328;8641269", "class_list": "", "function": "Component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWC4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0005774 vacuolar membrane;GO:0031932 TORC2 complex", "go_biological_process": "GO:0001558 regulation of cell growth;GO:0031929 TOR signaling;GO:0030950 establishment or maintenance of actin cytoskeleton polarity;GO:0038203 TORC2 signaling;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P47041-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47047-1", "uniprot_id": [ { "id": "MTR4_YEAST", "url": "https://www.uniprot.org/uniprot/P47047", "type": "external" } ], "mass": 122055.0, "length": 1073, "protein_name": "ATP-dependent RNA helicase DOB1", "gene_name": "MTR4", "organism": "Yeast", "refseq_name": "ATP-dependent RNA helicase MTR4", "refseq_ac": [ { "id": "NP_012485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012485", "type": "external" } ], "gene_names_uniprotkb": "MTR4; DOB1; J1158", "gene_names_refseq": "DOB1; MTR4", "protein_names_uniprotkb": "ATP-dependent RNA helicase DOB1; 3.6.4.13; mRNA transport regulator MTR4", "protein_names_refseq": "ATP-dependent RNA helicase MTR4", "tax_id": 559292, "disease": "amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (sce:YJL050W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "14562106;15828860;17287358;17563356;18407956;19779198;19795423;19823750;20702584;23749301;24374639;30047866;30516470;32597660;33481703;33491328;8641269;8756671;9463390", "class_list": "", "function": "ATP-dependent RNA helicase required for the 3'-end formation of 5.8S RNA. Cofactor for the exosome complex that unwinds secondary structure in pre-rRNA. Required for nucleocytoplasmic transport of mRNA. May serve as a chaperone which translocates or normalizes the structure of mRNAs in preparation for export. Component of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWD3", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.1.1.260", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.260", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0016491 oxidoreductase activity;GO:0034458 3'-5' RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0031499 TRAMP complex", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0034476 U5 snRNA 3'-end processing;GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process;GO:0006397 mRNA processing;GO:0000460 maturation of 5.8S rRNA", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P47047-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47054-1", "uniprot_id": [ { "id": "NU192_YEAST", "url": "https://www.uniprot.org/uniprot/P47054", "type": "external" } ], "mass": 191535.0, "length": 1683, "protein_name": "Nucleoporin NUP192", "gene_name": "NUP192", "organism": "Yeast", "refseq_name": "Nup192p", "refseq_ac": [ { "id": "NP_012495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012495", "type": "external" } ], "gene_names_uniprotkb": "NUP192; J1216", "gene_names_refseq": "NUP192", "protein_names_uniprotkb": "Nucleoporin NUP192; Nuclear pore protein NUP192", "protein_names_refseq": "Nup192p", "tax_id": 559292, "disease": "nephrotic syndrome type 13 (Disease Ontology:DOID:0080381)", "pathway": " (sce:YJL039C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10428845;10684247;11121302;12791264;14562106;23499021;23749301;24374639;33491328;8641269", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP192 is located to the NPC core at the nuclear membrane and is essential for de novo assembly of NPCs., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWE4", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0044611 nuclear pore inner ring", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:0015031 protein transport;GO:0046822 regulation of nucleocytoplasmic transport;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P47054-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47061-1", "uniprot_id": [ { "id": "VPS53_YEAST", "url": "https://www.uniprot.org/uniprot/P47061", "type": "external" } ], "mass": 95449.0, "length": 822, "protein_name": "Vacuolar protein sorting-associated protein 53", "gene_name": "VPS53", "organism": "Yeast", "refseq_name": "Vps53p", "refseq_ac": [ { "id": "NP_012505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012505", "type": "external" } ], "gene_names_uniprotkb": "VPS53; J1258", "gene_names_refseq": "VPS53", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 53", "protein_names_refseq": "Vps53p", "tax_id": 559292, "disease": "pontocerebellar hypoplasia type 2E (Disease Ontology:DOID:0060271)", "pathway": " (sce:YJL029C)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10637310;11689439;12377769;12446664;12620189;12686613;14562095;17287358;18407956;19779198;19795423;19823750;20702584;23749301;24374639;31208443;32597660;33481703;33491328;8641269", "class_list": "", "function": "Involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE TGL1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWF3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000938 GARP complex;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0010008 endosome membrane", "go_biological_process": "GO:0042147 retrograde transport, endosome to Golgi;GO:0090156 intracellular sphingolipid homeostasis;GO:0006623 protein targeting to vacuole;GO:0006896 Golgi to vacuole transport", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P47061-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47068-1", "uniprot_id": [ { "id": "BBC1_YEAST", "url": "https://www.uniprot.org/uniprot/P47068", "type": "external" } ], "mass": 128297.0, "length": 1157, "protein_name": "Myosin tail region-interacting protein MTI1", "gene_name": "BBC1", "organism": "Yeast", "refseq_name": "Bbc1p", "refseq_ac": [ { "id": "NP_012514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012514", "type": "external" } ], "gene_names_uniprotkb": "BBC1; J1286; J1305; MTI1; YJL021C", "gene_names_refseq": "BBC1; MTI1; YJL021C", "protein_names_uniprotkb": "Myosin tail region-interacting protein MTI1; Protein BBC1", "protein_names_refseq": "Bbc1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL020C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "11901111;15665377;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22106047;22218487;23749301;24374639;24909858;30516470;32597660;33229814;33481703;33491328;8641269", "class_list": "", "function": "Involved in the regulation of actin cytoskeleton., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 69, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "D6VWG0;P47067;Q8X1F4", "ec_number_list": [], "go_molecular_function": "GO:0017024 myosin I binding;GO:0032032 myosin I tail binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0030479 actin cortical patch", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization;GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P47068-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47083-1", "uniprot_id": [ { "id": "MPP10_YEAST", "url": "https://www.uniprot.org/uniprot/P47083", "type": "external" } ], "mass": 66953.0, "length": 593, "protein_name": "U3 small nucleolar RNA-associated protein MPP10", "gene_name": "MPP10", "organism": "Yeast", "refseq_name": "rRNA-processing protein MPP10", "refseq_ac": [ { "id": "NP_012535", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012535", "type": "external" } ], "gene_names_uniprotkb": "MPP10; J1411; YJR83.5", "gene_names_refseq": "MPP10", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein MPP10; M phase phosphoprotein 10; U3 snoRNA-associated protein MPP10", "protein_names_refseq": "rRNA-processing protein MPP10", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR002W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "12068309;15489263;15590835;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;20884785;21177495;22814378;23749301;24374639;30516470;32597660;33481703;33491328;8641269;9315638", "class_list": "", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA. Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWH6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030686 90S preribosome;GO:0005732 sno(s)RNA-containing ribonucleoprotein complex", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P47083-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47102-1", "uniprot_id": [ { "id": "GEA1_YEAST", "url": "https://www.uniprot.org/uniprot/P47102", "type": "external" } ], "mass": 159437.0, "length": 1408, "protein_name": "ARF guanine-nucleotide exchange factor 1", "gene_name": "GEA1", "organism": "Yeast", "refseq_name": "Arf family guanine nucleotide exchange factor GEA1", "refseq_ac": [ { "id": "NP_012565", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012565", "type": "external" } ], "gene_names_uniprotkb": "GEA1; J1580", "gene_names_refseq": "GEA1", "protein_names_uniprotkb": "ARF guanine-nucleotide exchange factor 1", "protein_names_refseq": "Arf family guanine nucleotide exchange factor GEA1", "tax_id": 559292, "disease": "Charcot-Marie-Tooth disease dominant intermediate A (Disease Ontology:DOID:0110202)", "pathway": " (sce:YJR031C); (R-SCE-6811438)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12808035;14562106;14734650;19039328;24374639;25190516;33491328;8619316;8641269;8945477", "class_list": "", "function": "Activates the ARF proteins by exchanging bound GDP for free GTP. Plays a role in maintaining mitochondrial morphology, and in the turnover of mitochondria through mitophagy (PubMed:25190516)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWK4", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane;GO:0000137 Golgi cis cisterna", "go_biological_process": "GO:0016236 macroautophagy;GO:0030036 actin cytoskeleton organization;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0032012 regulation of ARF protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P47102-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47108-1", "uniprot_id": [ { "id": "URB2_YEAST", "url": "https://www.uniprot.org/uniprot/P47108", "type": "external" } ], "mass": 135118.0, "length": 1174, "protein_name": "Nucleolar pre-ribosomal-associated protein 2", "gene_name": "URB2", "organism": "Yeast", "refseq_name": "ribosome biogenesis protein URB2", "refseq_ac": [ { "id": "NP_012575", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012575", "type": "external" } ], "gene_names_uniprotkb": "URB2; J1622; NPA2", "gene_names_refseq": "NPA2; URB2", "protein_names_uniprotkb": "Nucleolar pre-ribosomal-associated protein 2; Unhealthy ribosome biogenesis protein 2", "protein_names_refseq": "ribosome biogenesis protein URB2", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR041C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562095;14562106;15226434;15242642;17145778;21177495;24374639;33491328;7668047;8641269", "class_list": "", "function": "Required for 27S pre-rRNA processing. Has an early role during 60S ribosomal subunit assembly., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWL2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0042254 ribosome biogenesis;GO:0006364 rRNA processing;GO:0016072 rRNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P47108-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47115-1", "uniprot_id": [ { "id": "YJ26_YEAST", "url": "https://www.uniprot.org/uniprot/P47115", "type": "external" } ], "mass": 27361.0, "length": 236, "protein_name": "Uncharacterized protein YJR056C", "gene_name": "J1710", "organism": "Yeast", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_012590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_012590", "type": "external" } ], "gene_names_uniprotkb": "J1710", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein YJR056C", "protein_names_refseq": "uncharacterized protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR056C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562106;18407956;19684113;19779198;21177495;22218487;23749301;24374639;33481703;33491328;8641269;8840504", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWM7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P47115-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000000010.0000000000001.000.00000", "kg_view_protein": true } ]