[ { "uniprot_canonical_ac": "P00770-1", "uniprot_id": [ { "id": "MCPT2_RAT", "url": "https://www.uniprot.org/uniprot/P00770", "type": "external" } ], "mass": 27102.0, "length": 247, "protein_name": "Mast cell protease 2", "gene_name": "Mcpt2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mcpt2", "gene_names_refseq": "", "protein_names_uniprotkb": "Mast cell protease 2; 3.4.21.-; Group-specific protease; Mast cell protease II; rMCP-2; rMCP-II", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:29266)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "3233198;3549719;629933", "class_list": "", "function": "This enzyme, isolated from small intestine, specifically inactivates the apo forms of a certain group of intracellular pyridoxal phosphate-requiring enzymes. It has chymotrypsin-like specificity towards small substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P00770-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01230-1", "uniprot_id": [ { "id": "LSHB_RAT", "url": "https://www.uniprot.org/uniprot/P01230", "type": "external" } ], "mass": 15177.0, "length": 141, "protein_name": "Lutropin subunit beta", "gene_name": "Lhb", "organism": "Rat", "refseq_name": "lutropin subunit beta isoform 2 precursor", "refseq_ac": [ { "id": "NP_001029147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029147", "type": "external" } ], "gene_names_uniprotkb": "Lhb", "gene_names_refseq": "Lhb", "protein_names_uniprotkb": "Lutropin subunit beta; LH-B; LSH-B; LSH-beta; Luteinizing hormone subunit beta; Lutropin beta chain", "protein_names_refseq": "LH-B; LSH-B; LSH-beta; Luteinizing hormone (lutropin) subunit beta; luteinizing hormone beta polypeptide; luteinizing hormone beta subunit; lutropin beta chain; lutropin subunit beta isoform 2 precursor; lutropin subunit beta", "tax_id": 10116, "disease": "congenital disorder of glycosylation Iu (Disease Ontology:DOID:0080571); hypogonadotropic hypogonadism 23 with or without anosmia (Disease Ontology:DOID:0090091); severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": " (rno:25329); (R-RNO-193048); (R-RNO-193993); (R-RNO-209822); (R-RNO-375281); (R-RNO-8866910)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "23518923;23678542;23734233;25258388;6096374;6192440", "class_list": "", "function": "Data suggest that the molecular decision for LHbeta subunit to enter the regulated secretory pathway is a pre-Golgi event controlled by the C-terminal heptapeptide. Publication Status: Online-Only, [RefSeq, PubMed]; GnRH stimulates AMPK, and AMPK inhibition suppresses GnRH-stimulated LHbeta transcription., [RefSeq, PubMed]; Increased LH concentration induces production of incomplete LHR transcripts in hippocampal cells and decreases immature LHR at the protein level, [RefSeq, PubMed]; Orchestrated Egr1 and Pitx1 activities depending on specific central and peripheral regulatory inputs could be responsible for physiologically variable Lhb gene promoter activation in vivo., [RefSeq, PubMed]; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0001541 ovarian follicle development;GO:0042700 luteinizing hormone signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P01230-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01835-1", "uniprot_id": [ { "id": "KACB_RAT", "url": "https://www.uniprot.org/uniprot/P01835", "type": "external" } ], "mass": 11601.0, "length": 106, "protein_name": "Ig kappa chain C region, B allele", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig kappa chain C region, B allele", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "6273908;807630", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0042105 alpha-beta T cell receptor complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P01835-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01836-1", "uniprot_id": [ { "id": "KACA_RAT", "url": "https://www.uniprot.org/uniprot/P01836", "type": "external" } ], "mass": 11732.0, "length": 106, "protein_name": "Ig kappa chain C region, A allele", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig kappa chain C region, A allele", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6273908", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0042105 alpha-beta T cell receptor complex;GO:0071735 IgG immunoglobulin complex", "go_biological_process": "GO:0002250 adaptive immune response;GO:0030183 B cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01836-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04355-1", "uniprot_id": [ { "id": "MT2_RAT", "url": "https://www.uniprot.org/uniprot/P04355", "type": "external" } ], "mass": 6145.0, "length": 61, "protein_name": "Metallothionein-2", "gene_name": "Mt2", "organism": "Rat", "refseq_name": "metallothionein-2", "refseq_ac": [ { "id": "NP_001131036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131036", "type": "external" } ], "gene_names_uniprotkb": "Mt2", "gene_names_refseq": "MT-2; MT-II; Mt2A; Mt2", "protein_names_uniprotkb": "Metallothionein-2; MT-2; MT-II; Metallothionein-II", "protein_names_refseq": "metallothionein 2A; metallothionein-2; metallothionein-II", "tax_id": 10116, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); carotid stenosis (Disease Ontology:DOID:13001); transient cerebral ischemia (Disease Ontology:DOID:224); psychotic disorder (Disease Ontology:DOID:2468); median neuropathy (Disease Ontology:DOID:571); type 2 diabetes mellitus (Disease Ontology:DOID:9352); senile cataract (Disease Ontology:DOID:9669)", "pathway": " (rno:689415); (R-RNO-5661231)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "1694170;1942051;26732138;27147436;27173051;27939232;2959527;3184190;33849565;3653102;3945804;6470004;6853483", "class_list": "", "function": "Acute attack of experimental autoimmune encephalomyelitis was followed by increased expression of metallothioneins in molecular and granular cell layer of hippocampus., [RefSeq, PubMed]; Downregulation of metallothionein-2 contributes to oxaliplatin-induced neuropathic pain. Publication Status: Online-Only, [RefSeq, PubMed]; Melatonin -exhibited anti-allodynia is mediated by MT2-enhanced PP2Ac expression that couples PP2Ac with HDAC4 to induce HDAC4 dephosphorylation and nuclear import, herein increases HDAC4 binding to the promoter of hmgb1 gene and upregulates HMGB1 expression in dorsal horn neurons., [RefSeq, PubMed]; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids., [UniProtKB]; Observe a huge increase in MT3 transcripts in both cortical and hippocampal areas, while the MT1/2 mRNA content increases slightly, returning to the levels measured in adolescent rats, [RefSeq, PubMed]; The recurrent seizures plus normal diet group showed worse performances in neurological reflex tests and reduced latencies to myoclonic seizures induced by penicillin compared with the control, which was concomitant with altered expressions of ZnT-7, MT-1, MT-2, and ZIP7., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046870 cadmium ion binding;GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0048143 astrocyte activation;GO:0009617 response to bacterium;GO:0007263 nitric oxide mediated signal transduction;GO:0071276 cellular response to cadmium ion;GO:0071280 cellular response to copper ion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P04355-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04462-1", "uniprot_id": [ { "id": "MYH8_RAT", "url": "https://www.uniprot.org/uniprot/P04462", "type": "external" } ], "mass": 29844.0, "length": 257, "protein_name": "Myosin-8", "gene_name": "Myh8", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Myh8", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin-8; MyHC-perinatal; Myosin heavy chain 8; Myosin heavy chain, skeletal muscle, perinatal", "protein_names_refseq": "", "tax_id": 10116, "disease": "arthrogryposis multiplex congenita (Disease Ontology:DOID:0080954); distal arthrogryposis type 7 (Disease Ontology:DOID:0111603); disease of cellular proliferation (Disease Ontology:DOID:14566); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6149224", "class_list": "", "function": "Muscle contraction., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0000146 microfilament motor activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032982 myosin filament;GO:0030016 myofibril;GO:0016459 myosin complex", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0030049 muscle filament sliding;GO:0046034 ATP metabolic process;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P04462-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04563-1", "uniprot_id": [ { "id": "GAST_RAT", "url": "https://www.uniprot.org/uniprot/P04563", "type": "external" } ], "mass": 11832.0, "length": 104, "protein_name": "Gastrin", "gene_name": "Gast", "organism": "Rat", "refseq_name": "gastrin precursor", "refseq_ac": [ { "id": "NP_036981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036981", "type": "external" } ], "gene_names_uniprotkb": "Gast; Gas", "gene_names_refseq": "Gast; Gas; PPG34", "protein_names_uniprotkb": "Gastrin; G34; Gastrin-34", "protein_names_refseq": "gastrin precursor", "tax_id": 10116, "disease": "metabolic acidosis (Disease Ontology:DOID:0050758); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:25320); (R-RNO-416476); (R-RNO-881907)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12220729;1701434;19208342;21995960;25601282;25849341;3453895;38583887;6897117", "class_list": "", "function": "G cells are luminal sampling chemomechanosensory cells whose gastrin secretion is regulated by neural, hormonal, luminal, and mechanical factors through protein kinase A activation, cAMP signaling, and mitogen-activated protein kinase phosphorylation., [RefSeq, PubMed]; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine., [UniProtKB]; Gastrin: a new branch of the gastropancreatic axis that can explain the effect of sleeve gastrectomy on glucose metabolism., [RefSeq, PubMed]; Plays a role in the development of gastric mucosa, ECL cells and A-like cells in newborn and young rats, [RefSeq, PubMed]; The results suggested that clusterin may contribute to gastrin's growth-promoting effect on the oxyntic mucosa., [RefSeq, PubMed]; Treatment with gastrin, a CCK2R agonist, stimulated the secretion of GLP-1, and that this effect was likely due to increased expression of proglucagon and PCSK1 (also known as prohormone convertase 3 (PC3 gene))., [RefSeq, PubMed]; We examined the chronic effects of a GLP-1-gastrin dual agonist ZP3022 on glycemic control and beta cell dysfunction in overtly diabetic Zucker Diabetic Fatty, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032094 response to food", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P04563-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04906-1", "uniprot_id": [ { "id": "GSTP1_RAT", "url": "https://www.uniprot.org/uniprot/P04906", "type": "external" } ], "mass": 23439.0, "length": 210, "protein_name": "Glutathione S-transferase P", "gene_name": "Gstp1", "organism": "Rat", "refseq_name": "glutathione S-transferase P", "refseq_ac": [ { "id": "NP_036709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036709", "type": "external" } ], "gene_names_uniprotkb": "Gstp1", "gene_names_refseq": "GST-P; Gst3; Gstp1; Gstp2; Gstp", "protein_names_uniprotkb": "Glutathione S-transferase P; 2.5.1.18; Chain 7; GST 7-7; GST class-pi", "protein_names_refseq": "GST 7-7; GST class-pi; Glutathione-S-transferase, placental enzyme pi type; chain 7; glutathione S-transferase P; glutathione S-transferase, pi 2", "tax_id": 10116, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenoma (Disease Ontology:DOID:0050860); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); myelodysplastic syndrome (Disease Ontology:DOID:0050908); pre-malignant neoplasm (Disease Ontology:DOID:0060071); drug allergy (Disease Ontology:DOID:0060500); late onset Parkinson's disease (Disease Ontology:DOID:0060892); prostate cancer (Disease Ontology:DOID:10283); lymphoid leukemia (Disease Ontology:DOID:1037); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); osteoporosis (Disease Ontology:DOID:11476); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); allergic disease (Disease Ontology:DOID:1205); Graves' disease (Disease Ontology:DOID:12361); cholestasis (Disease Ontology:DOID:13580); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); respiratory system disease (Disease Ontology:DOID:1579); breast cancer (Disease Ontology:DOID:1612); congenital heart disease (Disease Ontology:DOID:1682); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); colon adenocarcinoma (Disease Ontology:DOID:234); multiple sclerosis (Disease Ontology:DOID:2377); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); testicular cancer (Disease Ontology:DOID:2998); acute kidney failure (Disease Ontology:DOID:3021); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); carotid artery disease (Disease Ontology:DOID:3407); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); toxic encephalopathy (Disease Ontology:DOID:3602); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); pulmonary fibrosis (Disease Ontology:DOID:3770); bronchus carcinoma (Disease Ontology:DOID:3904); lung non-small cell carcinoma (Disease Ontology:DOID:3908); liver disease (Disease Ontology:DOID:409); conjunctivochalasis (Disease Ontology:DOID:4250); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); movement disease (Disease Ontology:DOID:480); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); cholangiocarcinoma (Disease Ontology:DOID:4947); bone marrow disease (Disease Ontology:DOID:4961); peripheral nervous system disease (Disease Ontology:DOID:574); hepatocellular carcinoma (Disease Ontology:DOID:684); hematopoietic system disease (Disease Ontology:DOID:74); peritonitis (Disease Ontology:DOID:8283); lung disease (Disease Ontology:DOID:850); prostate carcinoma in situ (Disease Ontology:DOID:8634); myeloid leukemia (Disease Ontology:DOID:8692); psoriasis (Disease Ontology:DOID:8893); acute myeloid leukemia (Disease Ontology:DOID:9119); type 2 diabetes mellitus (Disease Ontology:DOID:9352); meningitis (Disease Ontology:DOID:9471); multiple myeloma (Disease Ontology:DOID:9538); senile cataract (Disease Ontology:DOID:9669); pulmonary emphysema (Disease Ontology:DOID:9675); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:24426); (R-RNO-156590); (R-RNO-3299685); (R-RNO-6798695); (R-RNO-9753281)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "29501922;2995915;3029128;3359441;34502162;3864155;38959295", "class_list": "", "function": "Catalyzes conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Acts as a negative regulator of ferroptosis by mediating glutathione conjugation and detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration., [UniProtKB, UniProtKB]; Gstp1 negatively regulates blood pressure in hypertensive rat via promoting APLNR ubiquitination degradation mediated by Nedd4., [RefSeq, PubMed]; The cytotoxic action of 2-acetylaminofluorene that give rise to the GST-P(+) single hepatocytes was suggested to be an injury to the excretory pump(s) and the duct of hepatocytes. A new physiological mechanism was hypothesized for the induction of preneoplastic cell populations in the rat liver instead of a genetic mechanism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 70, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0005504 fatty acid binding;GO:0015643 toxic substance binding;GO:0019901 protein kinase binding;GO:0035730 S-nitrosoglutathione binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0097057 TRAF2-GSTP1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0032869 cellular response to insulin stimulus;GO:0032930 positive regulation of superoxide anion generation;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P04906-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06214-1", "uniprot_id": [ { "id": "HEM2_RAT", "url": "https://www.uniprot.org/uniprot/P06214", "type": "external" } ], "mass": 36032.0, "length": 330, "protein_name": "Delta-aminolevulinic acid dehydratase", "gene_name": "Alad", "organism": "Rat", "refseq_name": "delta-aminolevulinic acid dehydratase isoform 1", "refseq_ac": [ { "id": "NP_037031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037031", "type": "external" } ], "gene_names_uniprotkb": "Alad", "gene_names_refseq": "ALADH; ALADR; Alad", "protein_names_uniprotkb": "Delta-aminolevulinic acid dehydratase; 4.2.1.24; ALADH; Porphobilinogen synthase", "protein_names_refseq": "aminolevulinate, delta-, dehydratase; aminolevulinatedelta-dehydratase; delta - aminolevulinic acid dehydratase; delta-aminolevulinic acid dehydratase isoform 1; delta-aminolevulinic acid dehydratase; porphobilinogen synthase", "tax_id": 10116, "disease": "sickle cell anemia (Disease Ontology:DOID:10923); hypothyroidism (Disease Ontology:DOID:1459); status epilepticus (Disease Ontology:DOID:1824); hemochromatosis (Disease Ontology:DOID:2352); anemia (Disease Ontology:DOID:2355); acute kidney failure (Disease Ontology:DOID:3021); porphyria cutanea tarda (Disease Ontology:DOID:3132); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (rno:25374); (R-RNO-189451); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "3502704;3808948", "class_list": "", "function": "Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0032791 lead ion binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0004655 porphobilinogen synthase activity;GO:1904854 proteasome core complex binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol", "go_biological_process": "GO:0033273 response to vitamin;GO:0046685 response to arsenic-containing substance;GO:0006979 response to oxidative stress;GO:0007584 response to nutrient;GO:0010043 response to zinc ion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P06214-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06341-1", "uniprot_id": [ { "id": "HB2A_RAT", "url": "https://www.uniprot.org/uniprot/P06341", "type": "external" } ], "mass": 26827.0, "length": 233, "protein_name": "Rano class II histocompatibility antigen, A beta chain", "gene_name": "RT1-B", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RT1-B", "gene_names_refseq": "", "protein_names_uniprotkb": "Rano class II histocompatibility antigen, A beta chain; RT1 class II histocompatibility antigen, A beta chain", "protein_names_refseq": "", "tax_id": 10116, "disease": "autoimmune pancreatitis (Disease Ontology:DOID:0040091); chikungunya (Disease Ontology:DOID:0050012); autoimmune polyendocrine syndrome type 2 (Disease Ontology:DOID:0050168); erythema multiforme (Disease Ontology:DOID:0050185); Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); marginal zone lymphoma (Disease Ontology:DOID:0050748); primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); rheumatic heart disease (Disease Ontology:DOID:0050827); cervical dystonia (Disease Ontology:DOID:0050840); stroke (Disease Ontology:DOID:0051061); immunoglobulin alpha deficiency (Disease Ontology:DOID:0060025); paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); latex allergy (Disease Ontology:DOID:0060532); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); pemphigus vulgaris (Disease Ontology:DOID:0060851); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); Parkinsonism (Disease Ontology:DOID:0080855); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); osteomyelitis (Disease Ontology:DOID:1019); pleurisy (Disease Ontology:DOID:10247); prostate cancer (Disease Ontology:DOID:10283); pneumoconiosis (Disease Ontology:DOID:10316); silicosis (Disease Ontology:DOID:10325); bacterial infectious disease (Disease Ontology:DOID:104); pre-eclampsia (Disease Ontology:DOID:10591); celiac disease (Disease Ontology:DOID:10608); Alzheimer's disease (Disease Ontology:DOID:10652); thrombotic thrombocytopenic purpura (Disease Ontology:DOID:10772); sickle cell anemia (Disease Ontology:DOID:10923); prostatic hypertrophy (Disease Ontology:DOID:11132); common wart (Disease Ontology:DOID:11165); sarcoidosis (Disease Ontology:DOID:11335); rhinoscleroma (Disease Ontology:DOID:11336); cryptorchidism (Disease Ontology:DOID:11383); osteoporosis (Disease Ontology:DOID:11476); cicatricial pemphigoid (Disease Ontology:DOID:11656); degenerative myopia (Disease Ontology:DOID:11829); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); allergic disease (Disease Ontology:DOID:1205); optic neuritis (Disease Ontology:DOID:1210); alveolar echinococcosis (Disease Ontology:DOID:12148); common variable immunodeficiency (Disease Ontology:DOID:12177); beta thalassemia (Disease Ontology:DOID:12241); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); aplastic anemia (Disease Ontology:DOID:12449); vulva cancer (Disease Ontology:DOID:1245); choreatic disease (Disease Ontology:DOID:12859); Sjogren's syndrome (Disease Ontology:DOID:12894); dilated cardiomyopathy (Disease Ontology:DOID:12930); agranulocytosis (Disease Ontology:DOID:12987); allergic bronchopulmonary aspergillosis (Disease Ontology:DOID:13166); Behcet's disease (Disease Ontology:DOID:13241); typhoid fever (Disease Ontology:DOID:13258); pure red-cell aplasia (Disease Ontology:DOID:1340); Addison's disease (Disease Ontology:DOID:13774); autoimmune polyendocrine syndrome (Disease Ontology:DOID:14040); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); hypothyroidism (Disease Ontology:DOID:1459); cystic echinococcosis (Disease Ontology:DOID:1495); rheumatic fever (Disease Ontology:DOID:1586); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); hepatitis C (Disease Ontology:DOID:1883); melanoma (Disease Ontology:DOID:1909); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); dental caries (Disease Ontology:DOID:216); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); ovarian cancer (Disease Ontology:DOID:2394); Leydig cell tumor (Disease Ontology:DOID:2696); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); antiphospholipid syndrome (Disease Ontology:DOID:2988); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); coronary artery disease (Disease Ontology:DOID:3393); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); tuberculosis (Disease Ontology:DOID:399); multidrug-resistant tuberculosis (Disease Ontology:DOID:401); autoimmune disease (Disease Ontology:DOID:417); systemic scleroderma (Disease Ontology:DOID:418); cervical cancer (Disease Ontology:DOID:4362); myasthenia gravis (Disease Ontology:DOID:437); macular degeneration (Disease Ontology:DOID:4448); rhinitis (Disease Ontology:DOID:4483); liver cirrhosis (Disease Ontology:DOID:5082); infertility (Disease Ontology:DOID:5223); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); myositis (Disease Ontology:DOID:633); migraine (Disease Ontology:DOID:6364); acute disseminated encephalomyelitis (Disease Ontology:DOID:639); pulmonary hypertension (Disease Ontology:DOID:6432); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); autoimmune thyroiditis (Disease Ontology:DOID:7188); stomach disease (Disease Ontology:DOID:76); hyperthyroidism (Disease Ontology:DOID:7998); sporadic breast cancer (Disease Ontology:DOID:8029); myocarditis (Disease Ontology:DOID:820); peritonitis (Disease Ontology:DOID:8283); osteoarthritis (Disease Ontology:DOID:8398); arthritis (Disease Ontology:DOID:848); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); prostate carcinoma in situ (Disease Ontology:DOID:8634); mycosis fungoides (Disease Ontology:DOID:8691); in situ carcinoma (Disease Ontology:DOID:8719); Crohn's disease (Disease Ontology:DOID:8778); neuromyelitis optica (Disease Ontology:DOID:8869); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); atrophic gastritis (Disease Ontology:DOID:8929); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); achalasia (Disease Ontology:DOID:9164); pemphigus (Disease Ontology:DOID:9182); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); iridocyclitis (Disease Ontology:DOID:9383); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3865896", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 134, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0009986 cell surface;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0042613 MHC class II protein complex", "go_biological_process": "GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0002250 adaptive immune response;GO:0050870 positive regulation of T cell activation;GO:0050778 positive regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P06341-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07490-1", "uniprot_id": [ { "id": "GON1_RAT", "url": "https://www.uniprot.org/uniprot/P07490", "type": "external" } ], "mass": 10500.0, "length": 92, "protein_name": "Progonadoliberin-1", "gene_name": "Gnrh1", "organism": "Rat", "refseq_name": "progonadoliberin-1 precursor", "refseq_ac": [ { "id": "NP_036899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036899", "type": "external" } ], "gene_names_uniprotkb": "Gnrh1; Gnrh", "gene_names_refseq": "Gnrh1; Gnrha; Gnrh; Lhrh; Rgnrhg1; SH-4", "protein_names_uniprotkb": "Progonadoliberin-1; GnRH-I; Gonadoliberin I; Gonadotropin-releasing hormone I; LH-RH I; Luliberin I; Luteinizing hormone-releasing hormone I; Progonadoliberin I; Prolactin release-inhibiting factor I", "protein_names_refseq": "Putative protein SH; gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); luteinizing hormone-releasing hormone; progonadoliberin I; progonadoliberin-1 precursor; progonadoliberin-1", "tax_id": 10116, "disease": "hypogonadotropic hypogonadism 12 with or without anosmia (Disease Ontology:DOID:0090072); prostatic hypertrophy (Disease Ontology:DOID:11132); breast cancer (Disease Ontology:DOID:1612); periodontitis (Disease Ontology:DOID:824)", "pathway": " (rno:25194); (R-RNO-375281); (R-RNO-416476)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "1468115;2476669;2867548;31272713;31430847;34268716;3547652;37797313;38129517", "class_list": "", "function": "FTO-mediated m[6]A demethylation regulates GnRH expression in the hypothalamus via the PLCbeta3/Ca[2+]/CAMK signalling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Mast Cell Dynamics in the Ovary Are Governed by GnRH and Prolactin., [RefSeq, PubMed]; Mutual Interactions Between GnRH and Kisspeptin in GnRH- and Kiss-1-Expressing Immortalized Hypothalamic Cell Models., [RefSeq, PubMed]; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones., [UniProtKB, UniProtKB, UniProtKB]; The data obtained confirm the regulatory or morphogenetic effect of GnRH on fetal thymus development mediated by synthesis of thymic cytokines. Publication Status: Online-Only, [RefSeq, PubMed]; The data suggest that alterations of histone H3 acetylation in the preoptic area and anteroventral periventricular nucleus and the inability of Ncoa2 and Crebbp to respond to estradiol in the middle-aged anterior hypothalamus partially contribute to the decline of GnRH neuron activation and estradiol target gene expression changes that occur in females along with reproductive aging., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005183 gonadotropin hormone-releasing hormone activity;GO:0031530 gonadotropin-releasing hormone receptor binding", "go_cellular_component": "GO:1990008 neurosecretory vesicle;GO:0005615 extracellular space;GO:0005798 Golgi-associated vesicle;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:1990637 response to prolactin;GO:0033087 negative regulation of immature T cell proliferation;GO:2000354 regulation of ovarian follicle development;GO:0032496 response to lipopolysaccharide;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P07490-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08011-1", "uniprot_id": [ { "id": "MGST1_RAT", "url": "https://www.uniprot.org/uniprot/P08011", "type": "external" } ], "mass": 17472.0, "length": 155, "protein_name": "Microsomal glutathione S-transferase 1", "gene_name": "Mgst1", "organism": "Rat", "refseq_name": "microsomal glutathione S-transferase 1", "refseq_ac": [ { "id": "NP_599176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599176", "type": "external" } ], "gene_names_uniprotkb": "Mgst1; Gst12", "gene_names_refseq": "Mgst1", "protein_names_uniprotkb": "Microsomal glutathione S-transferase 1; 2.5.1.18; Microsomal GST-1; Microsomal GST-I", "protein_names_refseq": "microsomal GST-1; microsomal GST-I; microsomal glutathione S-transferase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:171341); (R-RNO-156590); (R-RNO-5423646); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "11106493;16314419;16806268;21216258;21851097;24419913;28801553;3372534;3932348;6439207", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1., [RefSeq, PubMed]; Since Mgst1expression was reported to decline with age, our results could represent a putative adaptive process during aging. It could also be an early mechanism protecting neuronal cells against some neurodegenerative insults, [RefSeq, PubMed]; The functional unit is a homotrimer centered on the crystallographic three-fold axes of the unit cell. The GSH substrate binds in an extended conformation at the interface between two subunits of the trimer supported by new in vitro mutagenesis data. Publication Status: Online-Only, [RefSeq, PubMed]; Two doxorubicin derivatives/prodrugs (DNS-DOX; MNS-DOX) are substrates for MGST1; neoplasm drug resistance can be overcome in cell lines over-expressing recombinant MGST1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0042802 identical protein binding;GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0034635 glutathione transport;GO:0032496 response to lipopolysaccharide;GO:0033327 Leydig cell differentiation;GO:0009410 response to xenobiotic stimulus;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P08011-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08494-1", "uniprot_id": [ { "id": "MGP_RAT", "url": "https://www.uniprot.org/uniprot/P08494", "type": "external" } ], "mass": 12037.0, "length": 103, "protein_name": "Matrix Gla protein", "gene_name": "Mgp", "organism": "Rat", "refseq_name": "matrix Gla protein precursor", "refseq_ac": [ { "id": "NP_036994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036994", "type": "external" } ], "gene_names_uniprotkb": "Mgp", "gene_names_refseq": "Mglap; Mgp", "protein_names_uniprotkb": "Matrix Gla protein; MGP", "protein_names_refseq": "matrix Gla protein precursor", "tax_id": 10116, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); calcinosis (Disease Ontology:DOID:182); arteriosclerosis (Disease Ontology:DOID:2349); germinoma (Disease Ontology:DOID:3304); brain infarction (Disease Ontology:DOID:3454); renal cell carcinoma (Disease Ontology:DOID:4450); myocardial infarction (Disease Ontology:DOID:5844); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (rno:25333)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23445897;28707070;3317405;8061611", "class_list": "", "function": "Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation., [UniProtKB, UniProtKB, UniProtKB]; Contiuous expression of Matrix Gla protein contributes to crystal formation in kidney of hyperoxaluric animals., [RefSeq, PubMed]; High proliferative glioma cells expressing a high level of MGP may exist and contribute to tumor infiltration and recurrence., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007584 response to nutrient;GO:0030154 cell differentiation;GO:0051592 response to calcium ion;GO:0030324 lung development;GO:0051384 response to glucocorticoid", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P08494-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08661-1", "uniprot_id": [ { "id": "MBL2_RAT", "url": "https://www.uniprot.org/uniprot/P08661", "type": "external" } ], "mass": 26014.0, "length": 244, "protein_name": "Mannose-binding protein C", "gene_name": "AABR07006691.1; Mbl2", "organism": "Rat", "refseq_name": "mannose-binding protein C isoform 1 precursor", "refseq_ac": [ { "id": "NP_073195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073195", "type": "external" } ], "gene_names_uniprotkb": "AABR07006691.1; Mbl2; Mbl2", "gene_names_refseq": "Ab2-001; Ab2-011; Mbl2", "protein_names_uniprotkb": "Mannose-binding protein C; MBP-C; Mannan-binding protein; Ra-reactive factor polysaccharide-binding component p28A; RaRF p28A", "protein_names_refseq": "MBP-C; RA-reactive factor P28A subunit; RARF/P28A; mannan-binding protein; mannose binding lectin 2 (protein C); mannose-binding lectin (protein C) 2; mannose-binding protein C (liver); mannose-binding protein C isoform 1 precursor; mannose-binding protein C-like; ra-reactive factor polysaccharide-binding component p28A; raRF p28A", "tax_id": 10116, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); disease by infectious agent (Disease Ontology:DOID:0050117); Kartagener syndrome (Disease Ontology:DOID:0050144); chorioamnionitis (Disease Ontology:DOID:0050697); respiratory allergy (Disease Ontology:DOID:0060496); Cryptococcal meningitis (Disease Ontology:DOID:0080159); lupus nephritis (Disease Ontology:DOID:0080162); Coronavirus infectious disease (Disease Ontology:DOID:0080599); sensorineural hearing loss (Disease Ontology:DOID:10003); dermatomyositis (Disease Ontology:DOID:10223); bacterial infectious disease (Disease Ontology:DOID:104); Legionnaires' disease (Disease Ontology:DOID:10457); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); otitis media (Disease Ontology:DOID:10754); lepromatous leprosy (Disease Ontology:DOID:10887); respiratory failure (Disease Ontology:DOID:11162); adult respiratory distress syndrome (Disease Ontology:DOID:11394); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); common variable immunodeficiency (Disease Ontology:DOID:12177); vitiligo (Disease Ontology:DOID:12306); bronchopneumonia (Disease Ontology:DOID:12375); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); allergic bronchopulmonary aspergillosis (Disease Ontology:DOID:13166); lung cancer (Disease Ontology:DOID:1324); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); Kawasaki disease (Disease Ontology:DOID:13378); coccidioidomycosis (Disease Ontology:DOID:13450); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); toxic shock syndrome (Disease Ontology:DOID:14115); cystic fibrosis (Disease Ontology:DOID:1485); fungal infectious disease (Disease Ontology:DOID:1564); thrombocytopenia (Disease Ontology:DOID:1588); cryptosporidiosis (Disease Ontology:DOID:1733); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); vulvovaginal candidiasis (Disease Ontology:DOID:2272); leptospirosis (Disease Ontology:DOID:2297); ovarian cancer (Disease Ontology:DOID:2394); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); bipolar disorder (Disease Ontology:DOID:3312); bacterial vaginosis (Disease Ontology:DOID:3385); peripheral vascular disease (Disease Ontology:DOID:341); pulmonary fibrosis (Disease Ontology:DOID:3770); liver disease (Disease Ontology:DOID:409); coronary restenosis (Disease Ontology:DOID:4247); rhinitis (Disease Ontology:DOID:4483); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); aortic valve insufficiency (Disease Ontology:DOID:57); panic disorder (Disease Ontology:DOID:594); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); hepatocellular carcinoma (Disease Ontology:DOID:684); autoimmune thyroiditis (Disease Ontology:DOID:7188); end stage renal disease (Disease Ontology:DOID:783); polymyalgia rheumatica (Disease Ontology:DOID:853); herpes simplex (Disease Ontology:DOID:8566); bacterial pneumonia (Disease Ontology:DOID:874); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); visceral leishmaniasis (Disease Ontology:DOID:9146); pemphigus (Disease Ontology:DOID:9182); bronchiectasis (Disease Ontology:DOID:9563); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:64668); (R-RNO-166662)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10903744;11850428;1607365;21454685;22167201;3009480;3032924;8557671;9922165", "class_list": "", "function": "Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:11850428, PubMed:3009480, PubMed:8557671). Specifically recognizes and binds the mannose moiety of carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:11850428, PubMed:8557671)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 72, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0005771 multivesicular body;GO:0032991 protein-containing complex;GO:1905370 serine-type endopeptidase complex", "go_biological_process": "GO:0006508 proteolysis;GO:0043129 surfactant homeostasis;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0010954 positive regulation of protein processing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P08661-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09011-1", "uniprot_id": [ { "id": "MIP_RAT", "url": "https://www.uniprot.org/uniprot/P09011", "type": "external" } ], "mass": 28209.0, "length": 263, "protein_name": "Lens fiber major intrinsic protein", "gene_name": "Mip", "organism": "Rat", "refseq_name": "lens fiber major intrinsic protein", "refseq_ac": [ { "id": "NP_001099189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099189", "type": "external" } ], "gene_names_uniprotkb": "Mip", "gene_names_refseq": "Aqp0; Mip", "protein_names_uniprotkb": "Lens fiber major intrinsic protein; Aquaporin-0; MIP26; MP26", "protein_names_refseq": "MIP26; MP26; aquaporin-0; lens fiber major intrinsic protein; major intrinsic protein of eye lens fiber", "tax_id": 10116, "disease": "cataract 15 multiple types (Disease Ontology:DOID:0110251); cataract (Disease Ontology:DOID:83)", "pathway": " (rno:25480); (R-RNO-432047)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10067969;19281766;22020074;23226368;2377471;3174458;7848273", "class_list": "", "function": "Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient. Specifically expressed in lens fiber cells, this aquaporin is crucial for maintaining lens water homeostasis and transparency. Beyond water permeability, it also acts as a cell-to-cell adhesion molecule, forming thin junctions between lens fiber cells that are essential for maintaining the ordered structure and transparency of the lens., [UniProtKB, UniProtKB]; The kfrs4 rat represents the first characterised rat model with a recessive mutation in the Mip gene, [RefSeq, PubMed]; These findings suggest that AQP0 plays an important role in controlling lens ascorbic acid content., [RefSeq, PubMed]; These results show that changes in the subcellular distribution and processing of AQP0 occur at discrete stages during fiber cell differentiation in the eye lens and suggest that these stages of differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V6E0", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0015250 water channel activity;GO:0005212 structural constituent of eye lens;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0046691 intracellular canaliculus;GO:0070161 anchoring junction", "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:0015722 canalicular bile acid transport;GO:0007601 visual perception;GO:0006833 water transport;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P09011-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09416-1", "uniprot_id": [ { "id": "MYC_RAT", "url": "https://www.uniprot.org/uniprot/P09416", "type": "external" } ], "mass": 50561.0, "length": 453, "protein_name": "Myc proto-oncogene protein", "gene_name": "Myc", "organism": "Rat", "refseq_name": "myc proto-oncogene protein", "refseq_ac": [ { "id": "NP_036735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036735", "type": "external" } ], "gene_names_uniprotkb": "Myc", "gene_names_refseq": "Myc; RNCMYC; c-myc; mMyc", "protein_names_uniprotkb": "Myc proto-oncogene protein; Proto-oncogene c-Myc; Transcription factor p64", "protein_names_refseq": "Avian myelocytomatosis viral (v-myc) oncogene homolog; myc proto-oncogene protein; myelocytomatosis oncogene; myelocytomatosis viral oncogene homolog; proto-oncogene c-Myc; transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog", "tax_id": 10116, "disease": "angiosarcoma (Disease Ontology:DOID:0001816); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); alcohol-associated liver disease (Disease Ontology:DOID:0070658); polycystic kidney disease (Disease Ontology:DOID:0080322); polycystic kidney disease 1 (Disease Ontology:DOID:0110858); prostate cancer (Disease Ontology:DOID:10283); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); osteoporosis (Disease Ontology:DOID:11476); leiomyoma (Disease Ontology:DOID:127); brain cancer (Disease Ontology:DOID:1319); lung cancer (Disease Ontology:DOID:1324); hyperparathyroidism (Disease Ontology:DOID:13543); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); hepatitis C (Disease Ontology:DOID:1883); nephroblastoma (Disease Ontology:DOID:2154); prostate adenocarcinoma (Disease Ontology:DOID:2526); demyelinating disease (Disease Ontology:DOID:3213); rhabdoid cancer (Disease Ontology:DOID:3672); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); coronary restenosis (Disease Ontology:DOID:4247); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); pancreatic carcinoma (Disease Ontology:DOID:4905); liver cirrhosis (Disease Ontology:DOID:5082); prolactinoma (Disease Ontology:DOID:5394); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); Burkitt lymphoma (Disease Ontology:DOID:8584); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24577); (R-RNO-5689880); (R-RNO-8866911)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "17304222;20352099;3277717;3306601;33262248;35016888;35244724;36591933;38042369", "class_list": "", "function": "C-MYC ameliorates ventricular remodeling of myocardial infarction rats via binding to the promoter of microRNA-29a-3p to facilitate TET2 expression., [RefSeq, PubMed]; Correlation of Myc Expression with Wee1 Expression by Zanthoxylum acanthopodium in Cervical Carcinoma Histology., [RefSeq, PubMed]; Role of Myc Proto-Oncogene as a Transcriptional Hub to Regulate the Expression of Regeneration-Associated Genes following Preconditioning Peripheral Nerve Injury., [RefSeq, PubMed]; The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Rat mRNA also has a similarly placed CUG upstream of the AUG start site, suggesting that it may also produce two Myc proteins. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes (PubMed:17304222). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (By similarity). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transcriptional activation of the Myc gene by glucose in beta-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 35, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8L2Q2H7;Q6B500", "ec_number_list": [], "go_molecular_function": "GO:0071074 eukaryotic initiation factor eIF2 binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003729 mRNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0044195 nucleoplasmic reticulum;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0043279 response to alkaloid;GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:1904385 cellular response to angiotensin;GO:2001171 positive regulation of ATP biosynthetic process;GO:0071409 cellular response to cycloheximide", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P09416-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C0K5-1", "uniprot_id": [ { "id": "HAVR2_RAT", "url": "https://www.uniprot.org/uniprot/P0C0K5", "type": "external" } ], "mass": 30641.0, "length": 282, "protein_name": "Hepatitis A virus cellular receptor 2 homolog", "gene_name": "Havcr2", "organism": "Rat", "refseq_name": "hepatitis A virus cellular receptor 2 homolog precursor", "refseq_ac": [ { "id": "NP_001094232", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094232", "type": "external" } ], "gene_names_uniprotkb": "Havcr2; Tim3; Timd3", "gene_names_refseq": "Havcr2; tim3", "protein_names_uniprotkb": "Hepatitis A virus cellular receptor 2 homolog; HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; TIM-3; TIMD-3", "protein_names_refseq": "HAVcr-2; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; TIM-3; TIMD-3; hepatitis A virus cellular receptor 2 homolog precursor; hepatitis A virus cellular receptor 2 homolog", "tax_id": 10116, "disease": "subcutaneous panniculitis-like T-cell lymphoma (Disease Ontology:DOID:0070662); cystic fibrosis (Disease Ontology:DOID:1485); transient cerebral ischemia (Disease Ontology:DOID:224); pulmonary tuberculosis (Disease Ontology:DOID:2957); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:363578)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15020066;15913792;30677253;33168786;34847253;38527407", "class_list": "", "function": "A newly intervention strategy in preeclampsia: Targeting PD-1/Tim-3 signaling pathways to modulate the polarization of decidual macrophages., [RefSeq, PubMed]; Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits. In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN. Expressed on Treg cells can inhibit Th17 cell responses. Receptor for LGALS9. Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth. However, the function as receptor for LGALS9 has been challenged (By similarity). Also reported to enhance CD8+ T cell responses to an acute infection such as by Listeria monocytogenes. Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF. In tumor-infiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes. Can enhance mast cell production of Th2 cytokines Il-4, IL-6 and IL-13. Expressed on natural killer (NK) cells and acts as a coreceptor to enhance IFN-gamma production in response to LGALS9. In contrast, shown to suppress NK cell-mediated cytotoxicity. Negatively regulates NK cell function in LPS-induced endotoxic shock., [UniProtKB, UniProtKB, UniProtKB]; Galectin-9 and Tim-3 are upregulated in response to microglial activation induced by the peptide Amyloid-beta (25-35)., [RefSeq, PubMed]; Negative regulation of glial Tim-3 inhibits the secretion of inflammatory factors and modulates microglia to antiinflammatory phenotype after experimental intracerebral hemorrhage in rats., [RefSeq, PubMed]; Tim-3 deteriorates neuroinflammatory and neurocyte apoptosis after subarachnoid hemorrhage through the Nrf2/HMGB1 signaling pathway in rats., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "G3V9I4", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0001772 immunological synapse;GO:0016592 mediator complex", "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:0032703 negative regulation of interleukin-2 production;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P0C0K5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C7J6-1", "uniprot_id": [ { "id": "LRFN1_RAT", "url": "https://www.uniprot.org/uniprot/P0C7J6", "type": "external" } ], "mass": 81970.0, "length": 766, "protein_name": "Leucine-rich repeat and fibronectin type III domain-containing protein 1", "gene_name": "Lrfn1", "organism": "Rat", "refseq_name": "leucine-rich repeat and fibronectin type III domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_001121166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121166", "type": "external" } ], "gene_names_uniprotkb": "Lrfn1; Salm2", "gene_names_refseq": "Lrfn1", "protein_names_uniprotkb": "Leucine-rich repeat and fibronectin type III domain-containing protein 1; Synaptic adhesion-like molecule 2", "protein_names_refseq": "60S ribosomal protein L38-like; leucine-rich repeat and fibronectin type III domain-containing protein 1 precursor; leucine-rich repeat and fibronectin type III domain-containing protein 1; synaptic adhesion-like molecule 2", "tax_id": 10116, "disease": "", "pathway": " (rno:365222); (R-RNO-8849932)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16630835;18227064;38843836", "class_list": "", "function": "Promotes neurite outgrowth in hippocampal neurons (By similarity). Involved in the regulation of the differentiation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0009986 cell surface;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0099151 regulation of postsynaptic density assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0C7J6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CC09-1", "uniprot_id": [ { "id": "H2A2A_RAT", "url": "https://www.uniprot.org/uniprot/P0CC09", "type": "external" } ], "mass": 14095.0, "length": 130, "protein_name": "Histone H2A type 2-A", "gene_name": "H2ac18", "organism": "Rat", "refseq_name": "histone H2A type 1", "refseq_ac": [ { "id": "NP_001302422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001302422", "type": "external" } ], "gene_names_uniprotkb": "H2ac18; Hist2h2aa3", "gene_names_refseq": "H2A.2; H2ac18; Hist2h2aa1; Hist2h2aa3; Hist2h2aa", "protein_names_uniprotkb": "Histone H2A type 2-A; H2A-clustered histone 18; Histone H2A.2", "protein_names_refseq": "histone 2, H2aa; histone H2A type 1; histone cluster 2 H2A family member A3; histone cluster 2, H2aa1; histone cluster 2, H2aa3; histone cluster 2, H2aa", "tax_id": 10116, "disease": "", "pathway": " (rno:365877); (R-RNO-110330); (R-RNO-110331); (R-RNO-212300); (R-RNO-2299718); (R-RNO-2559580); (R-RNO-2559582); (R-RNO-2559586); (R-RNO-3214815); (R-RNO-3214858); (R-RNO-427359); (R-RNO-427413); (R-RNO-5250924); (R-RNO-5578749); (R-RNO-5625886); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-5689901); (R-RNO-606279); (R-RNO-68616); (R-RNO-73728); (R-RNO-73772); (R-RNO-8936459); (R-RNO-9018519); (R-RNO-9764725); (R-RNO-9841922); (R-RNO-9843940); (R-RNO-9843970); (R-RNO-9909649); (R-RNO-9940951); (R-RNO-9943411); (R-RNO-9943962); (R-RNO-9970672)", "pathway_count": 33, "publication_count": 2, "publication_id_list": "19343714;21239733", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0CC09-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11530-1", "uniprot_id": [ { "id": "DMD_RAT", "url": "https://www.uniprot.org/uniprot/P11530", "type": "external" } ], "mass": 425828.0, "length": 3677, "protein_name": "Dystrophin", "gene_name": "Dmd", "organism": "Rat", "refseq_name": "dystrophin isoform 1", "refseq_ac": [ { "id": "NP_001357805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001357805", "type": "external" } ], "gene_names_uniprotkb": "Dmd", "gene_names_refseq": "DNADMD1; Dmd", "protein_names_uniprotkb": "Dystrophin", "protein_names_refseq": "apodystrophin-3; apodystrophin-I; dystrophin isoform 1; dystrophin, muscular dystrophy; dystrophin-related", "tax_id": 10116, "disease": "small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); dilated cardiomyopathy 3B (Disease Ontology:DOID:0110461); intellectual disability (Disease Ontology:DOID:1059); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); dilated cardiomyopathy (Disease Ontology:DOID:12930); cognitive disorder (Disease Ontology:DOID:1561); status epilepticus (Disease Ontology:DOID:1824); brain edema (Disease Ontology:DOID:4724); congestive heart failure (Disease Ontology:DOID:6000); muscular atrophy (Disease Ontology:DOID:767); retinal degeneration (Disease Ontology:DOID:8466); Becker muscular dystrophy (Disease Ontology:DOID:9883); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (R-RNO-390522); (R-RNO-9913351)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10545507;22673903;3340214;34502162;35082358;36155058;37933572;38246612", "class_list": "", "function": "Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Identification and characterization of dystrophin-locus-derived testis-specific protein: A testis-specific gene within the intronic region of the rat dystrophin gene., [RefSeq, PubMed]; Nuclear transport and subcellular localization of the dystrophin Dp71 and Dp40 isoforms in the PC12 cell line., [RefSeq, PubMed]; Overexpression of the dystrophins Dp40 and Dp40L170P modifies neurite outgrowth and the protein expression profile of PC12 cells. Publication Status: Online-Only, [RefSeq, PubMed]; Plasticity occurs in a specific phenotype of neurons in the nucleus tractus solitarius of dystrophin gene-mutated rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1M705", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005178 integrin binding;GO:0008270 zinc ion binding;GO:0017022 myosin binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0014904 myotube cell development;GO:0021629 olfactory nerve structural organization;GO:1903409 reactive oxygen species biosynthetic process;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P11530-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12007-1", "uniprot_id": [ { "id": "IVD_RAT", "url": "https://www.uniprot.org/uniprot/P12007", "type": "external" } ], "mass": 46435.0, "length": 424, "protein_name": "Isovaleryl-CoA dehydrogenase, mitochondrial", "gene_name": "Ivd", "organism": "Rat", "refseq_name": "isovaleryl-CoA dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_036724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036724", "type": "external" } ], "gene_names_uniprotkb": "Ivd", "gene_names_refseq": "Ivd", "protein_names_uniprotkb": "Isovaleryl-CoA dehydrogenase, mitochondrial; 1.3.8.1; 1.3.8.4; Butyryl-CoA dehydrogenase; IVD", "protein_names_refseq": "butyryl-CoA dehydrogenase; isovaleryl coenzyme A dehydrogenase; isovaleryl-CoA dehydrogenase, mitochondrial precursor; isovaleryl-CoA dehydrogenase, mitochondrial", "tax_id": 10116, "disease": "isovaleric acidemia (Disease Ontology:DOID:14753); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (rno:24513); (R-RNO-70895)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "23474214;27213235;2777793;28100784;3446585;6401713", "class_list": "", "function": "A mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism, where isovaleryl-CoA (3-methylbutanoyl-CoA) is metabolized to 3-methylbut-2-enoyl-CoA. To a lesser extent, it also participates in the first step in fatty acid beta-oxidation, in which it catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of other saturated short-chain acyl-CoA thioesters such as pentanoyl-CoA, hexanoyl-CoA and butanoyl-CoA, using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Isovaleryl-CoA dehydrogenase has relatively broader substrate specificity than those of the other two enzymes in accommodating various substrate analogs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.4", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" } ], "go_molecular_function": "GO:0008470 3-methylbutanoyl-CoA dehydrogenase activity;GO:0042802 identical protein binding;GO:0050660 flavin adenine dinucleotide binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0009083 branched-chain amino acid catabolic process;GO:0006552 L-leucine catabolic process;GO:0006551 L-leucine metabolic process;GO:0046395 carboxylic acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P12007-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13832-1", "uniprot_id": [ { "id": "MRLCA_RAT", "url": "https://www.uniprot.org/uniprot/P13832", "type": "external" } ], "mass": 19895.0, "length": 172, "protein_name": "Myosin regulatory light chain RLC-A", "gene_name": "Rlc-a", "organism": "Rat", "refseq_name": "myosin regulatory light chain RLC-A", "refseq_ac": [ { "id": "NP_001128489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128489", "type": "external" } ], "gene_names_uniprotkb": "Rlc-a", "gene_names_refseq": "Myl12a; RGD1309537; Rlc-a", "protein_names_uniprotkb": "Myosin regulatory light chain RLC-A; Myosin RLC-A; Myosin regulatory light chain 2-A, smooth muscle isoform", "protein_names_refseq": "myosin RLC-A; myosin regulatory light chain RLC-A; myosin, light chain 12A, regulatory, non-sarcomeric", "tax_id": 10116, "disease": "", "pathway": " (rno:501203); (R-RNO-3928664); (R-RNO-445355)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "1649372;2391362;27233767;29393594;3584239;8034049", "class_list": "", "function": "Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity)., [UniProtKB]; Phosphorylation of myosin regulatory light chain (RLC) increased and remained elevated post-MI, while phosphorylation of myosin binding protein-C (MyBP-C) was initially depressed but then increased as the hearts became decompensated., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0051020 GTPase binding;GO:0032036 myosin heavy chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032991 protein-containing complex;GO:0016460 myosin II complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P13832-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14200-1", "uniprot_id": [ { "id": "MCH_RAT", "url": "https://www.uniprot.org/uniprot/P14200", "type": "external" } ], "mass": 18482.0, "length": 165, "protein_name": "Pro-MCH", "gene_name": "Pmch", "organism": "Rat", "refseq_name": "pro-MCH precursor", "refseq_ac": [ { "id": "NP_036757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036757", "type": "external" } ], "gene_names_uniprotkb": "Pmch; Mch", "gene_names_refseq": "Pmch", "protein_names_uniprotkb": "Pro-MCH", "protein_names_refseq": "pro-MCH precursor; pro-MCH", "tax_id": 10116, "disease": "sleeping sickness (Disease Ontology:DOID:10112); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24659); (R-RNO-375276); (R-RNO-416476); (R-RNO-418594)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "10037747;12964948;1327720;2261081;2477226;2759038;28867197;31034718;31664021;31917877;36565982;7617126;7647772;7783849;8593803;9145426;9575823;9700748;9809645", "class_list": "", "function": "A hypothalamus to telencephalon neural pathway for regulating impulsivity involved communication from melanin-concentrating hormone (MCH)-expressing lateral hypothalamic neurons to the ventral hippocampus subregion. Publication Status: Online-Only, [RefSeq, PubMed]; Acute intrahippocampal administration of melanin-concentrating hormone impairs memory consolidation and decreases the expression of MCHR-1 and TrkB receptors., [RefSeq, PubMed]; Characterisation and origins of melanin-concentrating hormone immunoreactive fibres of the posterior lobe of the pituitary and median eminence during lactation in the Long-Evans rat., [RefSeq, PubMed]; Neuropeptide ligand for the G protein-coupled receptor MCHR1 and MCHR2 that can activate both G(i/o)- and G(q/11)-dependent signaling pathways (By similarity). Acts as a neuromodulator in the central nervous system, promoting feeding, positive energy balance (orexigenic) and sleep (PubMed:12964948, PubMed:9575823). Inhibits stimulated ACTH release (lowering plasma glucocorticoids), consistent with a role in down-regulating hypothalamic-pituitary-adrenal (HPA) axis activity (PubMed:9575823). Functionally antagonizes melanotropin alpha (alpha-MSH), opposing its inhibitory effect on food intake and exploratory behaviors and its stimulatory effect on the HPA axis (PubMed:9145426, PubMed:9575823). Antagonizes NEI-induced behavioral effects (PubMed:9145426). May also participate in spermatocyte differentiation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]; Neuropeptide that modulates stress-related neuroendocrine responses and behaviors, increasing grooming, rearing and locomotor activity (PubMed:7647772, PubMed:9145426). Stimulates ACTH secretion, functionally counteracting the ACTH-suppressing action of MCH; the underlying mechanism is not fully characterized (PubMed:7647772). Reduces dopamine and DOPAC release in the ventromedial nucleus (PubMed:9700748). Influences differentiation of neuronal processes and affects neurofilament protein content in vitro (PubMed:9809645)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Prolactin maintains transient melanin-concentrating hormone expression in the medial preoptic area during established lactation., [RefSeq, PubMed]; Results show that the number of Melanin Concentrating hormone-immunoreactive neurons in the Medial Preoptic Area is positively correlated with the number of pups in the litter and that artificially reducing the number of pups can also decrease the number of MCH-immunoreactive neurons in the MPOA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030354 melanin-concentrating hormone activity;GO:0031777 type 1 melanin-concentrating hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0045202 synapse", "go_biological_process": "GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0007611 learning or memory;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P14200-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15431-1", "uniprot_id": [ { "id": "GBRB1_RAT", "url": "https://www.uniprot.org/uniprot/P15431", "type": "external" } ], "mass": 54072.0, "length": 474, "protein_name": "Gamma-aminobutyric acid receptor subunit beta-1", "gene_name": "Gabrb1", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid receptor subunit beta-1 precursor", "refseq_ac": [ { "id": "NP_037088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037088", "type": "external" } ], "gene_names_uniprotkb": "Gabrb1; Gabrb-1", "gene_names_refseq": "GARB1; Gabrb1", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit beta-1; GABA(A) receptor subunit beta-1; GABAAR subunit beta-1", "protein_names_refseq": "GABA(A) receptor subunit beta-1; GABAAR subunit beta-1; Gamma-aminobutyric acid receptor beta 1; gamma-aminobutyric acid (GABA) A receptor, beta 1; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1; gamma-aminobutyric acid receptor subunit beta-1 precursor; gamma-aminobutyric acid receptor subunit beta-1; gamma-aminobutyric acid type A receptor beta 1 subunit", "tax_id": 10116, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); developmental and epileptic encephalopathy 45 (Disease Ontology:DOID:0080428); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); autistic disorder (Disease Ontology:DOID:12849); hepatic encephalopathy (Disease Ontology:DOID:13413); depressive disorder (Disease Ontology:DOID:1596); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:25450); (R-RNO-977443)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1977069;22215379;23176253;2548852;29706582;30044221;33636639;38843836", "class_list": "", "function": "Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:1977069). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:30044221). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:1977069). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (PubMed:1977069). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Bone marrow stem cells and adult stem cells were found to express GABA-A alpha2 and beta3, but not beta1 mRNA transcripts., [RefSeq, PubMed]; In inhibitory transmission onto hippocampal CA1 pyramidal cells, deletion of all beta subunits 1, 2, and 3 completely eliminated inhibitory responses. In addition, only knockout of beta3, alone or in combination with another beta subunit, impaired inhibitory synaptic transmission. expression of beta3 alone on the background of the beta1-3 subunit knockout was sufficient to restore synaptic and extrasynaptic inhibitory ..., [RefSeq, PubMed]; Stimulation of brain alpha7-nicotinic acetylcholine receptors suppresses the rat micturition through brain GABAergic receptors., [RefSeq, PubMed]; We conclude that is a greater contribution of beta(1) -subunit-containing GABA(A) receptors following oxygen and glucose deprivation in cerebellar Purkinje cells, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0005253 monoatomic anion channel activity;GO:0050811 GABA receptor binding;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005635 nuclear envelope;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0032570 response to progesterone;GO:0009636 response to toxic substance;GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P15431-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15978-1", "uniprot_id": [ { "id": "HA11_RAT", "url": "https://www.uniprot.org/uniprot/P15978", "type": "external" } ], "mass": 36570.0, "length": 319, "protein_name": "Class I histocompatibility antigen, Non-RT1.A alpha-1 chain", "gene_name": "RT1-Aw2", "organism": "Rat", "refseq_name": "class I histocompatibility antigen, Non-RT1.A alpha-1 chain precursor", "refseq_ac": [ { "id": "NP_036777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036777", "type": "external" } ], "gene_names_uniprotkb": "RT1-Aw2", "gene_names_refseq": "MHCRTA; RATMHCRTA; RT1-Aw2; RT1-A; RT1.Al; RT1.EC2; RT1Aw2; RTS; Rt1-ec2", "protein_names_uniprotkb": "Class I histocompatibility antigen, Non-RT1.A alpha-1 chain", "protein_names_refseq": "MHC class I antigen; MHC class Ia protein; RT1 class I histocompatibility antigen, AA alpha chain; RT1 class Ib gene RT1Aw2; RT1 class Ib gene(Aw2); RT1 class Ib, locus Aw2; class I histocompatibility antigen, Non-RT1.A alpha-1 chain precursor; class I histocompatibility antigen, Non-RT1.A alpha-1 chain", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); hereditary multiple exostoses (Disease Ontology:DOID:206); germ cell cancer (Disease Ontology:DOID:2994); chondrosarcoma (Disease Ontology:DOID:3371)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "15240697;2315309;3585249", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030881 beta-2-microglobulin binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0030670 phagocytic vesicle membrane;GO:0042612 MHC class I protein complex;GO:0098553 lumenal side of endoplasmic reticulum membrane", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0006955 immune response;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P15978-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16391-1", "uniprot_id": [ { "id": "HA12_RAT", "url": "https://www.uniprot.org/uniprot/P16391", "type": "external" } ], "mass": 41830.0, "length": 371, "protein_name": "RT1 class I histocompatibility antigen, AA alpha chain", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "RT1 class I histocompatibility antigen, AA alpha chain", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "11163232;11591757;12719799;2315309;7871571", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O02940", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030881 beta-2-microglobulin binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0030670 phagocytic vesicle membrane;GO:0042612 MHC class I protein complex;GO:0098553 lumenal side of endoplasmic reticulum membrane", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0006955 immune response;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P16391-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18211-1", "uniprot_id": [ { "id": "HB2D_RAT", "url": "https://www.uniprot.org/uniprot/P18211", "type": "external" } ], "mass": 29876.0, "length": 264, "protein_name": "Rano class II histocompatibility antigen, D-1 beta chain", "gene_name": "RT1-Db1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RT1-Db1", "gene_names_refseq": "", "protein_names_uniprotkb": "Rano class II histocompatibility antigen, D-1 beta chain; RT1 class II histocompatibility antigen, D-1 beta chain", "protein_names_refseq": "", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); autoimmune polyendocrine syndrome type 2 (Disease Ontology:DOID:0050168); primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); rheumatic heart disease (Disease Ontology:DOID:0050827); stroke (Disease Ontology:DOID:0051061); latex allergy (Disease Ontology:DOID:0060532); lupus nephritis (Disease Ontology:DOID:0080162); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); sensorineural hearing loss (Disease Ontology:DOID:10003); leprosy (Disease Ontology:DOID:1024); prostate cancer (Disease Ontology:DOID:10283); bacterial infectious disease (Disease Ontology:DOID:104); celiac disease (Disease Ontology:DOID:10608); Alzheimer's disease (Disease Ontology:DOID:10652); Alport syndrome (Disease Ontology:DOID:10983); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); sarcoidosis (Disease Ontology:DOID:11335); cicatricial pemphigoid (Disease Ontology:DOID:11656); diabetic angiopathy (Disease Ontology:DOID:11713); sympathetic ophthalmia (Disease Ontology:DOID:12029); allergic disease (Disease Ontology:DOID:1205); optic neuritis (Disease Ontology:DOID:1210); Chagas disease (Disease Ontology:DOID:12140); alveolar echinococcosis (Disease Ontology:DOID:12148); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); vulva cancer (Disease Ontology:DOID:1245); paracoccidioidomycosis (Disease Ontology:DOID:12662); autistic disorder (Disease Ontology:DOID:12849); choreatic disease (Disease Ontology:DOID:12859); Sjogren's syndrome (Disease Ontology:DOID:12894); thromboangiitis obliterans (Disease Ontology:DOID:12918); retinopathy of prematurity (Disease Ontology:DOID:13025); uveitis (Disease Ontology:DOID:13141); allergic bronchopulmonary aspergillosis (Disease Ontology:DOID:13166); Behcet's disease (Disease Ontology:DOID:13241); typhoid fever (Disease Ontology:DOID:13258); temporal arteritis (Disease Ontology:DOID:13375); pure red-cell aplasia (Disease Ontology:DOID:1340); uveoparotid fever (Disease Ontology:DOID:13404); pulmonary sarcoidosis (Disease Ontology:DOID:13406); Addison's disease (Disease Ontology:DOID:13774); polyneuropathy (Disease Ontology:DOID:1389); schistosomiasis (Disease Ontology:DOID:1395); autoimmune polyendocrine syndrome (Disease Ontology:DOID:14040); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); cystic echinococcosis (Disease Ontology:DOID:1495); urticaria (Disease Ontology:DOID:1555); rheumatic fever (Disease Ontology:DOID:1586); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); hepatitis C (Disease Ontology:DOID:1883); autoimmune hepatitis (Disease Ontology:DOID:2048); multiple sclerosis (Disease Ontology:DOID:2377); Takayasu's arteritis (Disease Ontology:DOID:2508); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); antiphospholipid syndrome (Disease Ontology:DOID:2988); breast carcinoma (Disease Ontology:DOID:3459); mixed connective tissue disease (Disease Ontology:DOID:3492); cerebral infarction (Disease Ontology:DOID:3526); tuberculosis (Disease Ontology:DOID:399); multidrug-resistant tuberculosis (Disease Ontology:DOID:401); autoimmune disease (Disease Ontology:DOID:417); myasthenia gravis (Disease Ontology:DOID:437); renal cell carcinoma (Disease Ontology:DOID:4450); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myositis (Disease Ontology:DOID:633); acute disseminated encephalomyelitis (Disease Ontology:DOID:639); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); autoimmune thyroiditis (Disease Ontology:DOID:7188); peptic ulcer disease (Disease Ontology:DOID:750); abdominal aortic aneurysm (Disease Ontology:DOID:7693); infectious mononucleosis (Disease Ontology:DOID:8568); neuromyelitis optica (Disease Ontology:DOID:8869); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); atrophic gastritis (Disease Ontology:DOID:8929); diabetic retinopathy (Disease Ontology:DOID:8947); narcolepsy (Disease Ontology:DOID:8986); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); systemic lupus erythematosus (Disease Ontology:DOID:9074); pemphigus (Disease Ontology:DOID:9182); allergic asthma (Disease Ontology:DOID:9415); type 1 diabetes mellitus (Disease Ontology:DOID:9744); Meniere's disease (Disease Ontology:DOID:9849)", "pathway": " (R-RNO-202424); (R-RNO-202427); (R-RNO-202430); (R-RNO-202433); (R-RNO-2132295); (R-RNO-389948)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "2388838", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 95, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding;GO:0042609 CD4 receptor binding;GO:0042608 T cell receptor binding", "go_cellular_component": "GO:0009986 cell surface;GO:0005765 lysosomal membrane;GO:0009897 external side of plasma membrane;GO:0031902 late endosome membrane;GO:0042613 MHC class II protein complex", "go_biological_process": "GO:0002842 positive regulation of T cell mediated immune response to tumor cell;GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0045622 regulation of T-helper cell differentiation;GO:0006955 immune response;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P18211-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18589-1", "uniprot_id": [ { "id": "MX2_RAT", "url": "https://www.uniprot.org/uniprot/P18589", "type": "external" } ], "mass": 75074.0, "length": 659, "protein_name": "Interferon-induced GTP-binding protein Mx2", "gene_name": "Mx2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mx2", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon-induced GTP-binding protein Mx2; Myxovirus resistance protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); liver disease (Disease Ontology:DOID:409); avian influenza (Disease Ontology:DOID:4492); myocardial infarction (Disease Ontology:DOID:5844); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (R-RNO-1169408)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18062906;2173790", "class_list": "", "function": "Interferon-induced dynamin-like GTPase with antiviral activity against vesicular stomatitis virus (VSV)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:0071357 cellular response to type I interferon;GO:0046822 regulation of nucleocytoplasmic transport;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0009615 response to virus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P18589-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19468-1", "uniprot_id": [ { "id": "GSH1_RAT", "url": "https://www.uniprot.org/uniprot/P19468", "type": "external" } ], "mass": 72619.0, "length": 637, "protein_name": "Glutamate--cysteine ligase catalytic subunit", "gene_name": "Gclc", "organism": "Rat", "refseq_name": "glutamate--cysteine ligase catalytic subunit", "refseq_ac": [ { "id": "NP_036947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036947", "type": "external" } ], "gene_names_uniprotkb": "Gclc; Glclc", "gene_names_refseq": "Gclc; Glclc", "protein_names_uniprotkb": "Glutamate--cysteine ligase catalytic subunit; 6.3.2.2; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase", "protein_names_refseq": "GCS heavy chain; Glutamylcysteine gamma synthetase light chain; gamma-ECS; gamma-glutamylcysteine synthetase; glutamate--cysteine ligase catalytic subunit", "tax_id": 10116, "disease": "congenital nonspherocytic hemolytic anemia 7 (Disease Ontology:DOID:0111681); cystic fibrosis (Disease Ontology:DOID:1485); liver cirrhosis (Disease Ontology:DOID:5082); hemolytic anemia (Disease Ontology:DOID:583); myocardial infarction (Disease Ontology:DOID:5844); cataract (Disease Ontology:DOID:83); colorectal cancer (Disease Ontology:DOID:9256); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:25283); (R-RNO-174403)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1967255;22673903;23682816;25016074;27998794", "class_list": "", "function": "Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis., [UniProtKB, UniProtKB]; In diabetic retinopathy, histone methylation at Gclc-ARE4 plays an important role in regulating the Nrf2-Gclc-GSH cascade., [RefSeq, PubMed]; Increased GCLC protein expression in the lungs were observed in the rats exposed to biomass smoke and cigarette smoke., [RefSeq, PubMed]; Study determined the effects of troxerutin on cognitive deficits and glutamate cysteine ligase subunits (GCLM and GCLC) in the hippocampus of streptozotocin-induced type 1 diabetes mellitus rat: troxerutin alleviates oxidative stress and promotes learning potential in STZ-induced diabetic rats likely through GCL mechanisms, especially that of GCLC., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.2", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0043531 ADP binding;GO:0004357 glutamate-cysteine ligase activity;GO:0016595 glutamate binding", "go_cellular_component": "GO:0017109 glutamate-cysteine ligase complex;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0046685 response to arsenic-containing substance;GO:0051900 regulation of mitochondrial depolarization;GO:0097069 cellular response to thyroxine stimulus;GO:0006536 glutamate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P19468-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19627-1", "uniprot_id": [ { "id": "GNAZ_RAT", "url": "https://www.uniprot.org/uniprot/P19627", "type": "external" } ], "mass": 40880.0, "length": 355, "protein_name": "Guanine nucleotide-binding protein G(z) subunit alpha", "gene_name": "Gnaz", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein G(z) subunit alpha", "refseq_ac": [ { "id": "NP_037321", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037321", "type": "external" } ], "gene_names_uniprotkb": "Gnaz", "gene_names_refseq": "GXA; Gnaz; Hg1h", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(z) subunit alpha; G(x) alpha chain; Gz-alpha", "protein_names_refseq": "Guanine nucleotide binding protein alpha; g(x) alpha chain; guanine nucleotide binding protein (G protein), alpha z polypeptide; guanine nucleotide binding protein, alpha z polypeptide; guanine nucleotide binding protein, alpha z subunit; guanine nucleotide-binding protein G(z) subunit alpha; gz-alpha; heterotrimeric guanine nucleotide-binding protein 1h", "tax_id": 10116, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); McCune Albright syndrome (Disease Ontology:DOID:1858); communication disorder (Disease Ontology:DOID:2033)", "pathway": " (rno:25740); (R-RNO-418597)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15919662;16157560;18525017;2456569;38843836", "class_list": "", "function": "An endogenous receptor-mediated signaling process in pancreatic beta-cells is dependent on G alpha(z) function., [RefSeq, PubMed]; Central Galphaz (inhibitory) and Galphaq (stimulatory) activity differentially modulates AVP release to control the pattern of diuresis to intracerebroventricular nociceptin., [RefSeq, PubMed]; Endothelin-1 in picomolar concentrations can interrupt prolactin release for several hours downstream of spontaneous and high K+-stimulated voltage-gated Ca2+ influx. This action occurred through the Gz signaling pathway., [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031821 G protein-coupled serotonin receptor binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse;GO:0044297 cell body", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0046676 negative regulation of insulin secretion;GO:0098664 G protein-coupled serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P19627-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19969-1", "uniprot_id": [ { "id": "GBRA5_RAT", "url": "https://www.uniprot.org/uniprot/P19969", "type": "external" } ], "mass": 52337.0, "length": 464, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-5", "gene_name": "Gabra5", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-5 precursor", "refseq_ac": [ { "id": "NP_058991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058991", "type": "external" } ], "gene_names_uniprotkb": "Gabra5; Gabra-5", "gene_names_refseq": "Gabra5", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-5; GABA(A) receptor subunit alpha-5; GABAAR subunit alpha-5", "protein_names_refseq": "GABA(A) receptor subunit alpha-5; GABA-A receptor alpha-5 subunit; GABAAR subunit alpha-5; gamma-aminobutyric acid (GABA) A receptor, alpha 5; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5; gamma-aminobutyric acid A receptor, alpha 5; gamma-aminobutyric acid receptor subunit alpha-5 precursor; gamma-aminobutyric acid receptor subunit alpha-5; gamma-aminobutyric acid type A receptor alpha 5 subunit", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 79 (Disease Ontology:DOID:0112215); autistic disorder (Disease Ontology:DOID:12849); depressive disorder (Disease Ontology:DOID:1596); bipolar disorder (Disease Ontology:DOID:3312)", "pathway": " (rno:29707); (R-RNO-977443)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10462548;1660002;2153588;2157817;2561977;31249307;32240868;32750173;34937496;35732272;38843836", "class_list": "", "function": "Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10462548, PubMed:1660002, PubMed:2153588). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:10462548, PubMed:1660002, PubMed:2153588). GABAARs containing alpha-5/GABRA5 subunits are mainly extrasynaptic and contribute to the tonic GABAergic inhibition in the hippocampus (By similarity). Extrasynaptic alpha-5-containing GABAARs in CA1 pyramidal neurons play a role in learning and memory processes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Alteration of the alpha5 GABA receptor and 5HTT lead to cognitive deficits associated with major depressive-like behaviors in a 14-day combined stress rat model., [RefSeq, PubMed]; Gabra5 overexpression increased tonic GABA currents and normalized aberrant pyramidal cell activity in the ventral hippocampus. Publication Status: Online-Only, [RefSeq, PubMed]; Positive Allosteric Modulation of alpha5-GABAA Receptors Reverses Stress-Induced Alterations in Dopamine System Function and Prepulse Inhibition of Startle., [RefSeq, PubMed]; Sex-dependent pronociceptive role of spinal alpha5 -GABAA receptor and its epigenetic regulation in neuropathic rodents., [RefSeq, PubMed]; Significance of inhibitory recruitment in aging with preserved cognition: limiting gamma-aminobutyric acid type A alpha5 function produces memory impairment., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0050811 GABA receptor binding;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043235 receptor complex;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0060384 innervation;GO:0008306 associative learning;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P19969-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21794-1", "uniprot_id": [ { "id": "HIP70_RAT", "url": "https://www.uniprot.org/uniprot/P21794", "type": "external" } ], "mass": 2113.0, "length": 19, "protein_name": "Hormone-induced protein 70 kDa", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Hormone-induced protein 70 kDa; HIP-70", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2181662", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P21794-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23574-1", "uniprot_id": [ { "id": "GBRG1_RAT", "url": "https://www.uniprot.org/uniprot/P23574", "type": "external" } ], "mass": 53551.0, "length": 465, "protein_name": "Gamma-aminobutyric acid receptor subunit gamma-1", "gene_name": "Gabrg1", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid receptor subunit gamma-1 precursor", "refseq_ac": [ { "id": "NP_542153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542153", "type": "external" } ], "gene_names_uniprotkb": "Gabrg1", "gene_names_refseq": "Gabrg1", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit gamma-1; GABA(A) receptor subunit gamma-1; GABAAR subunit gamma-1", "protein_names_refseq": "GABA(A) receptor subunit gamma-1; GABAAR subunit gamma-1; gamma-aminobutyric acid (GABA) A receptor, gamma 1; gamma-aminobutyric acid A receptor, gamma 1; gamma-aminobutyric acid receptor subunit gamma-1 precursor; gamma-aminobutyric acid receptor subunit gamma-1; gamma-aminobutyric acid type A receptor gamma 1 subunit", "tax_id": 10116, "disease": "trigeminal neuralgia (Disease Ontology:DOID:12098)", "pathway": " (rno:140674)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18292084;2170110;24425869;33288547", "class_list": "", "function": "GABAA Receptors Expressed in Oligodendrocytes Cultured from the Neonatal Rat Contain alpha3 and gamma1 Subunits and Present Differential Functional and Pharmacological Properties., [RefSeq, PubMed]; Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:2170110). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:2170110). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors, [RefSeq, PubMed]; Switching the intracellular domains of the gamma2 and gamma1 subunits substantiated this inference. Because this region determines post-synaptic localization, we hypothesize that GABAARs containing gamma1 and gamma2 use different mechanisms for synaptic clustering., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0050811 GABA receptor binding;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:0005254 chloride channel activity;GO:0005230 extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0045211 postsynaptic membrane;GO:0098794 postsynapse;GO:0034707 chloride channel complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0007268 chemical synaptic transmission;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P23574-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24528-1", "uniprot_id": [ { "id": "MGMT_RAT", "url": "https://www.uniprot.org/uniprot/P24528", "type": "external" } ], "mass": 22244.0, "length": 209, "protein_name": "Methylated-DNA--protein-cysteine methyltransferase", "gene_name": "Mgmt", "organism": "Rat", "refseq_name": "methylated-DNA--protein-cysteine methyltransferase", "refseq_ac": [ { "id": "NP_036993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036993", "type": "external" } ], "gene_names_uniprotkb": "Mgmt", "gene_names_refseq": "Mgmt", "protein_names_uniprotkb": "Methylated-DNA--protein-cysteine methyltransferase; 2.1.1.63; 6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase", "protein_names_refseq": "0-6-methylguanine-DNA methyltransferase; 6-O-methylguanine-DNA methyltransferase; O(6)-alkylguanine-DNA alkyltransferase; O-6-methylguanine-DNA-alkyltransferase; O6-alkylguanine-DNA alkyltransferase; O6-methylguanine-DNA methyltranferase; methylated-DNA--protein-cysteine methyltransferase", "tax_id": 10116, "disease": "autosomal dominant Robinow syndrome 3 (Disease Ontology:DOID:0060767); urinary bladder cancer (Disease Ontology:DOID:11054); neurodegenerative disease (Disease Ontology:DOID:1289); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); pancreatic endocrine carcinoma (Disease Ontology:DOID:1798); melanoma (Disease Ontology:DOID:1909); colon adenocarcinoma (Disease Ontology:DOID:234); cervix carcinoma (Disease Ontology:DOID:2893); granulosa cell tumor (Disease Ontology:DOID:2999); glioblastoma (Disease Ontology:DOID:3068); oligodendroglioma (Disease Ontology:DOID:3181); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); cholangiocarcinoma (Disease Ontology:DOID:4947); gastrinoma (Disease Ontology:DOID:5577); retinoblastoma (Disease Ontology:DOID:768)", "pathway": " (rno:25332)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1945835;20051376;2013136;2049083;32433023;8202360;8467487", "class_list": "", "function": "Folate deficiency resulted in significant increases in levels of the DNA repair proteins OGG-1 and MGMT in the liver, [RefSeq, PubMed]; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MGMT-Mediated neuron Apoptosis in Injured Rat Spinal Cord., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.63", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.63", "type": "external" } ], "go_molecular_function": "GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity;GO:0003677 DNA binding;GO:0005509 calcium ion binding;GO:0008168 methyltransferase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0043066 negative regulation of apoptotic process;GO:0045471 response to ethanol;GO:0006307 DNA alkylation repair;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P24528-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24898-1", "uniprot_id": [ { "id": "JUNB_RAT", "url": "https://www.uniprot.org/uniprot/P24898", "type": "external" } ], "mass": 35765.0, "length": 344, "protein_name": "Transcription factor JunB", "gene_name": "Junb", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Junb; Jun-b", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor JunB; Transcription factor AP-1 subunit JunB", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:24517)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1542584;22673903;29393594;39676507", "class_list": "", "function": "Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P733", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0090575 RNA polymerase II transcription regulator complex;GO:0035976 transcription factor AP-1 complex", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0033687 osteoblast proliferation;GO:0001570 vasculogenesis;GO:0001701 in utero embryonic development;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P24898-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27704-1", "uniprot_id": [ { "id": "MK06_RAT", "url": "https://www.uniprot.org/uniprot/P27704", "type": "external" } ], "mass": 82275.0, "length": 720, "protein_name": "Mitogen-activated protein kinase 6", "gene_name": "Mapk6", "organism": "Rat", "refseq_name": "mitogen-activated protein kinase 6", "refseq_ac": [ { "id": "NP_113810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113810", "type": "external" } ], "gene_names_uniprotkb": "Mapk6; Erk3; Prkm6", "gene_names_refseq": "ERK3; Mapk6", "protein_names_uniprotkb": "Mitogen-activated protein kinase 6; 2.7.11.24; ERK-3; Extracellular signal-regulated kinase 3; MAP kinase 6; MAPK 6; p55-MAPK", "protein_names_refseq": "ERK-3; MAP kinase 6; MAPK 6; extracellular signal-regulated kinase 3; mitogen-activated protein kinase 6; p55-MAPK", "tax_id": 10116, "disease": "", "pathway": " (rno:58840); (R-RNO-5687128)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12808096;15269285;2032290;24411019;25187167;28429763;30118880;33404840", "class_list": "", "function": "Analysis revealed that the effects of miR-26a in VSMCs were mediated by targeting MAPK6 at the mRNA and protein levels. Publication Status: Online-Only, [RefSeq, PubMed]; Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity)., [UniProtKB]; ERK3 biological activity is regulated by its cellular abundance through the control of protein stability, [RefSeq, PubMed]; It plays distinct role in proliferation, differentiation, and neuronal viability., [RefSeq, PubMed]; MiR-26a-5p could act as a negative regulator of neuropathic pain development through targeting MAPK6, [RefSeq, PubMed]; TGF-beta1-modified MSC-derived exosomal miR-135b attenuates cartilage injury via promoting M2 synovial macrophage polarization by targeting MAPK6., [RefSeq, PubMed]; These data suggest a novel mechanism for the localization of an MAPK family member, ERK3, in which cell cycle-regulated, site-specific proteolysis generates the nuclear form of the protein., [RefSeq, PubMed]; Thsi study validated the Hprt1, Actb, Mapk6 or B2m and showed that any one or combination of two of them are good reference genes for normalization of mRNA expression in qPCR experiments in the spinal cord and RVM in the CFA model of inflammatory injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32LY4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0032156 septin cytoskeleton;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0060999 positive regulation of dendritic spine development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P27704-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28471-1", "uniprot_id": [ { "id": "GBRA4_RAT", "url": "https://www.uniprot.org/uniprot/P28471", "type": "external" } ], "mass": 60951.0, "length": 552, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-4", "gene_name": "Gabra4", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-4 precursor", "refseq_ac": [ { "id": "NP_542154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542154", "type": "external" } ], "gene_names_uniprotkb": "Gabra4", "gene_names_refseq": "Gabra4", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-4; GABA(A) receptor subunit alpha-4; GABAAR subunit alpha-4", "protein_names_refseq": "GABA(A) receptor subunit alpha-4; GABA-A receptor alpha-4 subunit; GABAAR subunit alpha-4; gamma-aminobutyric acid (GABA) A receptor, alpha 4; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4; gamma-aminobutyric acid receptor subunit alpha-4 precursor; gamma-aminobutyric acid receptor subunit alpha-4; gamma-aminobutyric acid type A receptor alpha4 subunit", "tax_id": 10116, "disease": "autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (rno:140675); (R-RNO-977443)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1655526;24090084;25223733;27382064;28218471", "class_list": "", "function": "Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). Alpha-4/GABRA4 subunit often assembles with delta or gamma-2 subunits, in combination with beta subunits (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). GABAARs containing alpha-4 are predominantly extrasynaptic, contributing to tonic inhibition in dentate granule cells and thalamic relay neurons (By similarity). Extrasynaptic alpha-4-containing GABAARs control levels of excitability and network activity (By similarity). GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Spontaneous, recurrent seizures that define chronic epilepsy may influence changes in GABAA receptor alpha4 expression, [RefSeq, PubMed]; Study shows that alpha4betadelta-GABAA receptors in dorsal hippocampal CA1 of adolescent female rats traffic to the plasma membrane of dendritic spines following voluntary exercise and contribute to protection of animals from activity-based anorexia through localization at excitatory synapses., [RefSeq, PubMed]; The subunit arrangement of alpha4beta2delta GABAA receptors is not strongly predefined but is mostly satisfying the 2:2:1 subunit stoichiometry for alpha4, beta2, and delta subunits and that several subunit arrangements result in receptors with similar functional properties tuned to physiological conditions., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0098794 postsynapse;GO:0034707 chloride channel complex;GO:0032590 dendrite membrane;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0007417 central nervous system development;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P28471-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28494-1", "uniprot_id": [ { "id": "MA2A1_RAT", "url": "https://www.uniprot.org/uniprot/P28494", "type": "external" } ], "mass": 131242.0, "length": 1148, "protein_name": "Alpha-mannosidase 2", "gene_name": "Man2a1", "organism": "Rat", "refseq_name": "alpha-mannosidase 2", "refseq_ac": [ { "id": "NP_037111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037111", "type": "external" } ], "gene_names_uniprotkb": "Man2a1; Mana2", "gene_names_refseq": "Man2a1; Mana2; Manno", "protein_names_uniprotkb": "Alpha-mannosidase 2; 3.2.1.114; AMan II; Golgi alpha-mannosidase II; Man II; Mannosidase alpha class 2A member 1; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase", "protein_names_refseq": "AMan II; MAN II; alpha-mannosidase 2; alpha-mannosidase II; golgi alpha-mannosidase II; mannosidase 2, alpha 1; mannosidase alpha 2; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase", "tax_id": 10116, "disease": "congenital dyserythropoietic anemia (Disease Ontology:DOID:1338); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:25478); (R-RNO-975578)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1885615;2246269;22673903;24741992;25797317;2748583", "class_list": "glycogene;glycosylhydrolase", "function": "Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data suggest that hepatocyte expression of Man2a1 (Golgi apparatus alpha-mannosidase) and Man2b1 (lysosome alpha-mannosidase) is down-regulated by biological toxin swainsonine as part of locoweed/Oxytropis kansuensis hepatotoxic damage., [RefSeq, PubMed]; Swainsonine from Oxytropis kansuensis could reduce the expression of MAN2A1 in brain tissues, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G3V7Y9", "ec_number_list": [ { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.114", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005797 Golgi medial cisterna;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0001701 in utero embryonic development;GO:0001889 liver development;GO:0048286 lung alveolus development;GO:0007585 respiratory gaseous exchange by respiratory system", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P28494-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000001000.0000000011001.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28826-1", "uniprot_id": [ { "id": "MEP1B_RAT", "url": "https://www.uniprot.org/uniprot/P28826", "type": "external" } ], "mass": 79236.0, "length": 704, "protein_name": "Meprin A subunit beta", "gene_name": "Mep1b", "organism": "Rat", "refseq_name": "meprin A subunit beta isoform 2 precursor", "refseq_ac": [ { "id": "NP_037315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037315", "type": "external" } ], "gene_names_uniprotkb": "Mep1b", "gene_names_refseq": "Mep1b", "protein_names_uniprotkb": "Meprin A subunit beta; 3.4.24.63; Endopeptidase-2; Meprin B", "protein_names_refseq": "endopeptidase-2; meprin 1 beta; meprin A beta; meprin A subunit beta isoform 2 precursor; meprin B", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (rno:25727)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1377685;15695509;18509531;18786924;8760356", "class_list": "", "function": "Identifies proIL-18 as a biologically important substrate for meprin beta and implicates meprins in the modulation of inflammation, [RefSeq, PubMed]; In anti-Thy 1.1 glomerulonephritis we observed striking redistribution of meprin beta in tubular epithelial cells from the apical to the basolateral side and the cytosol. This might point to an involvement of meprin beta in this form of glomerulonephritis Publication Status: Online-Only, [RefSeq, PubMed]; Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q642D0", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0017090 meprin A complex;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P28826-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28902-1", "uniprot_id": [ { "id": "GUC2A_RAT", "url": "https://www.uniprot.org/uniprot/P28902", "type": "external" } ], "mass": 12574.0, "length": 115, "protein_name": "Guanylin", "gene_name": "Guca2a", "organism": "Rat", "refseq_name": "guanylin precursor", "refseq_ac": [ { "id": "NP_037250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037250", "type": "external" } ], "gene_names_uniprotkb": "Guca2a; Guca2", "gene_names_refseq": "GUANYL; Guanylin; Guca2a; Guca2", "protein_names_uniprotkb": "Guanylin; Guanylate cyclase activator 2A", "protein_names_refseq": "guanylate cyclase activator 2 (guanylin); guanylate cyclase activator 2a (guanylin); guanylin precursor", "tax_id": 10116, "disease": "pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); pulmonary sarcoidosis (Disease Ontology:DOID:13406); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); pneumonia (Disease Ontology:DOID:552); lung disease (Disease Ontology:DOID:850); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25656); (R-RNO-8935690)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "1346555;1378267;1379587;14986129;22310983;23081987;26249840;27044258;29097254", "class_list": "", "function": "Data (including data from studies in transgenic rats) suggest guanylin--guanylyl cyclase-C signaling in macrophages in mesenteric fat regulates cGMP--PKG--VASP pathway and mesenteric panniculitis/obesity via down-regulation of proinflammatory factors., [RefSeq, PubMed]; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins., [UniProtKB]; Guanylin is synthesized as an intrinsic peptide in epithelial cells of the hepatobiliary system and released luminally into the hepatic and cystic bile to regulate electrolyte secretion by a paracrine/luminocrine signaling pathway, [RefSeq, PubMed]; The early diffuse guanylin immunoreactivity we observed in ducts and acinar anlage, before the secretory set is operative, suggests guanylin has a role in cell differentiation. (Guanylin), [RefSeq, PubMed]; The macrophagic guanylin-GC-C system contributes to the altered expression of genes involved in lipid metabolism, leading to resistance to obesity, [RefSeq, PubMed]; The specific cellular distribution of both GN and UGN differs between duodenum and colon and between human and rat intestines., [RefSeq, PubMed]; These results support the hypothesis that IL-15 secreted from Gn-GC-C-expressing macrophages contributes to the inhibition of fatty acid synthase and lipid accumulation in adipocytes, leading to obesity resistance, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030249 guanylate cyclase regulator activity;GO:0030250 guanylate cyclase activator activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P28902-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30969-1", "uniprot_id": [ { "id": "GNRHR_RAT", "url": "https://www.uniprot.org/uniprot/P30969", "type": "external" } ], "mass": 37748.0, "length": 327, "protein_name": "Gonadotropin-releasing hormone receptor", "gene_name": "Gnrhr", "organism": "Rat", "refseq_name": "gonadotropin-releasing hormone receptor", "refseq_ac": [ { "id": "NP_112300", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112300", "type": "external" } ], "gene_names_uniprotkb": "Gnrhr", "gene_names_refseq": "GH1; Gnrhr; Lhrhr", "protein_names_uniprotkb": "Gonadotropin-releasing hormone receptor; GnRH receptor; GnRH-R", "protein_names_refseq": "gnRH receptor; gnRH-R; gonadotropin-releasing hormone receptor; growth hormone", "tax_id": 10116, "disease": "primary sclerosing cholangitis (Disease Ontology:DOID:0060643); hypogonadotropic hypogonadism 7 with or without anosmia (Disease Ontology:DOID:0090078); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:81668); (R-RNO-375281); (R-RNO-416476)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "1338727;1339279;22356123;27349532;27569529;28032117;33576068;7764374;7916600;8185587;9828194", "class_list": "", "function": "GnRH-R is expressed in the mammary tissues after weaning; GnRH is involved in the involution and tissue remodeling of post-lactating rat mammary tissues, [RefSeq, PubMed]; Gonadotrophin-releasing hormone receptor autoantibodies induce polycystic ovary syndrome-like features in a rat model., [RefSeq, PubMed]; Prevention of estradiol synthesis blocked the ability of peripheral estradiol administration in ovariectomized rats to enhance hippocampus-dependent memory in a radial-maze task. Hippocampal GnRH receptor antagonism blocked the ability of peripheral estradiol administration in ovariectomized rats to enhance hippocampus-dependent memory. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB]; The age-dependent basal and regulated Gnrhr transcription could account for the initial blockade and subsequent activation of the reproductive system during development., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004968 gonadotropin-releasing hormone receptor activity;GO:0016520 growth hormone-releasing hormone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0032870 cellular response to hormone stimulus;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P30969-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35053-1", "uniprot_id": [ { "id": "GPC1_RAT", "url": "https://www.uniprot.org/uniprot/P35053", "type": "external" } ], "mass": 61734.0, "length": 558, "protein_name": "Glypican-1", "gene_name": "Gpc1", "organism": "Rat", "refseq_name": "glypican-1 precursor", "refseq_ac": [ { "id": "NP_110455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110455", "type": "external" } ], "gene_names_uniprotkb": "Gpc1", "gene_names_refseq": "Gpc1; HSPG M12; HSPGM12", "protein_names_uniprotkb": "Glypican-1; HSPG M12", "protein_names_refseq": "GPI-anchored cell surface heparan sulfate proteoglycan; glypican-1 precursor", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:58920); (R-RNO-1971475); (R-RNO-2022928); (R-RNO-2024096); (R-RNO-975634); (R-RNO-9769739)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "1417860;14707133;15383532;16407548;23851278;24090084;32647868;8207484", "class_list": "", "function": "Cell surface proteoglycan that bears heparan sulfate. May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. Binds Cu(2+) or Zn(2+) ions (By similarity). Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination., [UniProtKB, PubMed, PubMed]; Cell surface proteoglycan., [UniProtKB, UniProtKB]; The glycocalyx core protein Glypican 1 protects vessel wall endothelial cells from stiffness-mediated dysfunction and disease., [RefSeq, PubMed]; These data suggest that fluid shear stress induced the cell junctional clustering of lipid rafts with their anchored glypican-1 and associated HS., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 196, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043236 laminin binding;GO:0005507 copper ion binding;GO:0017134 fibroblast growth factor binding;GO:0070052 collagen V binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0016477 cell migration;GO:0014037 Schwann cell differentiation;GO:0032288 myelin assembly;GO:0030200 heparan sulfate proteoglycan catabolic process;GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P35053-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35345-1", "uniprot_id": [ { "id": "MC5R_RAT", "url": "https://www.uniprot.org/uniprot/P35345", "type": "external" } ], "mass": 37050.0, "length": 325, "protein_name": "Melanocortin receptor 5", "gene_name": "Mc5r", "organism": "Rat", "refseq_name": "melanocortin receptor 5", "refseq_ac": [ { "id": "NP_037314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037314", "type": "external" } ], "gene_names_uniprotkb": "Mc5r", "gene_names_refseq": "Mc5r", "protein_names_uniprotkb": "Melanocortin receptor 5; MC5-R", "protein_names_refseq": "MC5-R; melanocortin receptor 5", "tax_id": 10116, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (rno:25726); (R-RNO-375276)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "14660008;17531155;22643233;8179577", "class_list": "", "function": "Compared with low-activity rats, high-activity rats show enhanced mRNA expression of MCRs in the brain, specifically of MC3R in the paraventricular nucleus, and MC4R and MC5R in the perifornical lateral hypothalamus., [RefSeq, PubMed]; Expression levels of melanocortin 3 receptor (MC3R) and melanocortin 5 receptor (MC5R) were not significantly affected by high dietary salt intake in either WKY or SP-SHR tissues Publication Status: Online-Only, [RefSeq, PubMed]; G protein-coupled receptor for melanocyte-stimulating hormones (alpha- beta- and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor. Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway. Also activates ERK1/2 via a PI3K-dependent signaling mechanism. Order of potency of natural melanocortins in receptor activation is alpha-MSH > ACTH > beta-MSH > gamma-MSH (By similarity). Plays a key role in immune response, and is essential for temperature regulation and exocrine gland function (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Mc5 receptor expression is localized to the ganglion cell and inner nuclear layers in adult retina and superior colliculus and is decreased after optic nerve transection., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0042562 hormone binding;GO:0004977 melanocortin receptor activity;GO:0004978 corticotropin receptor activity;GO:0004980 melanocyte-stimulating hormone receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0001659 temperature homeostasis;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0050777 negative regulation of immune response;GO:0045921 positive regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P35345-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37361-1", "uniprot_id": [ { "id": "MT3_RAT", "url": "https://www.uniprot.org/uniprot/P37361", "type": "external" } ], "mass": 6809.0, "length": 66, "protein_name": "Metallothionein-3", "gene_name": "Mt3", "organism": "Rat", "refseq_name": "metallothionein-3", "refseq_ac": [ { "id": "NP_446420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446420", "type": "external" } ], "gene_names_uniprotkb": "Mt3", "gene_names_refseq": "GIF; Mt-3; Mt3", "protein_names_uniprotkb": "Metallothionein-3; GIF; Growth inhibitory factor; MT-3; MT-III; Metallothionein-III", "protein_names_refseq": "MT-III; growth inhibitory factor; metallothionein III; metallothionein-3", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypothyroidism (Disease Ontology:DOID:1459); transient cerebral ischemia (Disease Ontology:DOID:224); motor neuron disease (Disease Ontology:DOID:231); psychotic disorder (Disease Ontology:DOID:2468); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); multiple system atrophy (Disease Ontology:DOID:4752); borna disease (Disease Ontology:DOID:5154); median neuropathy (Disease Ontology:DOID:571)", "pathway": " (rno:117038); (R-RNO-5661231)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10366715;25778834;27939232;38904023;7677777;8412560", "class_list": "", "function": "After passing middle age we observe a huge increase in MT3 transcripts in both cortical and hippocampal areas, while the MT1/2 mRNA content increases slightly, [RefSeq, PubMed]; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity)., [UniProtKB]; Metallothionein 3 Potentiates Pulmonary Artery Smooth Muscle Cell Proliferation by Promoting Zinc-MTF1-ATG5 Axis-mediated Autophagosome Formation. Publication Status: Online-Only, [RefSeq, PubMed]; Rats treated with KD (EXP2) showed a significant down-regulated expression of ZnT-3, MT-3, ApoE, clusterin, and ACAT-1 in hippocampus, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046870 cadmium ion binding;GO:0008270 zinc ion binding;GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005874 microtubule", "go_biological_process": "GO:2000296 negative regulation of hydrogen peroxide catabolic process;GO:0032095 regulation of response to food;GO:0006829 zinc ion transport;GO:0001934 positive regulation of protein phosphorylation;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P37361-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39069-1", "uniprot_id": [ { "id": "KAD1_RAT", "url": "https://www.uniprot.org/uniprot/P39069", "type": "external" } ], "mass": 21584.0, "length": 194, "protein_name": "Adenylate kinase isoenzyme 1", "gene_name": "AABR07051450.1; Ak1", "organism": "Rat", "refseq_name": "adenylate kinase isoenzyme 1", "refseq_ac": [ { "id": "NP_077325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077325", "type": "external" } ], "gene_names_uniprotkb": "AABR07051450.1; Ak1; AABR07051450.1; AK1; Ak1", "gene_names_refseq": "Ak 1; Ak1", "protein_names_uniprotkb": "Adenylate kinase isoenzyme 1; 2.7.4.3; 2.7.4.4; 2.7.4.6; AK 1; ATP-AMP transphosphorylase 1; ATP:AMP phosphotransferase; Adenylate monophosphate kinase; Myokinase", "protein_names_refseq": "ATP-AMP transphosphorylase 1; ATP:AMP phosphotransferase; adenylate kinase isoenzyme 1-like; adenylate kinase isoenzyme 1; adenylate monophosphate kinase; myokinase", "tax_id": 10116, "disease": "congenital nonspherocytic hemolytic anemia 3 (Disease Ontology:DOID:0051004); neuronal ceroid lipofuscinosis 5 (Disease Ontology:DOID:0110728); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); middle cerebral artery infarction (Disease Ontology:DOID:3525); hemolytic anemia (Disease Ontology:DOID:583); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24183); (R-RNO-499943)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "22673903;23620342;34192805;8468325", "class_list": "", "function": "Activation of AMP kinase ameliorates kidney vascular dysfunction, oxidative stress and inflammation in rodent models of obesity., [RefSeq, PubMed]; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP (By similarity)., [UniProtKB, UniProtKB, UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]; Data indicate that the beta-alanine administration was able to inhibit the enzyme pyruvate kinase, cytosolic creatine kinase, and adenylate kinase activities in cerebral cortex, and increase in cerebellum., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBC5;Q9JJN3", "ec_number_list": [ { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0004550 nucleoside diphosphate kinase activity;GO:0047506 dAMP kinase activity;GO:0019205 nucleobase-containing compound kinase activity", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006172 ADP biosynthetic process;GO:0046033 AMP metabolic process;GO:0046103 inosine biosynthetic process;GO:0007517 muscle organ development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P39069-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41243-1", "uniprot_id": [ { "id": "MATK_RAT", "url": "https://www.uniprot.org/uniprot/P41243", "type": "external" } ], "mass": 51897.0, "length": 467, "protein_name": "Megakaryocyte-associated tyrosine-protein kinase", "gene_name": "Matk", "organism": "Rat", "refseq_name": "megakaryocyte-associated tyrosine-protein kinase isoform 1", "refseq_ac": [ { "id": "NP_068631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068631", "type": "external" } ], "gene_names_uniprotkb": "Matk; Batk; Ctk", "gene_names_refseq": "Batk; Matk", "protein_names_uniprotkb": "Megakaryocyte-associated tyrosine-protein kinase; 2.7.10.2; Protein kinase BATK; Tyrosine-protein kinase CTK", "protein_names_refseq": "megakaryocyte-associated tyrosine kinase (non-receptor protein tyrosine kinase); megakaryocyte-associated tyrosine-protein kinase isoform 1; megakaryocyte-associated tyrosine-protein kinase; non-receptor protein kinase protein; protein kinase BATK; tyrosine-protein kinase CTK", "tax_id": 10116, "disease": "", "pathway": " (rno:60450)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21393838;7807586", "class_list": "", "function": "Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain., [UniProtKB]; The CHK SH2 was expressed in Escherichia coli and the purified protein was characterized as monomeric by synchrotron small-angle X-ray scattering in-line with size-exclusion chromatography., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P41243-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43219-1", "uniprot_id": [ { "id": "GIPR_RAT", "url": "https://www.uniprot.org/uniprot/P43219", "type": "external" } ], "mass": 52257.0, "length": 455, "protein_name": "Gastric inhibitory polypeptide receptor", "gene_name": "Gipr", "organism": "Rat", "refseq_name": "gastric inhibitory polypeptide receptor precursor", "refseq_ac": [ { "id": "NP_036846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036846", "type": "external" } ], "gene_names_uniprotkb": "Gipr", "gene_names_refseq": "Gippr; Gipr; RATGIPPR", "protein_names_uniprotkb": "Gastric inhibitory polypeptide receptor; GIP-R; Glucose-dependent insulinotropic polypeptide receptor", "protein_names_refseq": "GIP-R; gastric inhibitory peptide receptor; gastric inhibitory polypeptide receptor precursor; glucose-dependent insulinotropic polypeptide receptor", "tax_id": 10116, "disease": "dopamine beta-hydroxylase deficiency (Disease Ontology:DOID:0090145); migraine with aura (Disease Ontology:DOID:10024); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); cardiovascular system disease (Disease Ontology:DOID:1287); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); brain ischemia (Disease Ontology:DOID:2316); hyperglycemia (Disease Ontology:DOID:4195); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25024); (R-RNO-420092)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "23689510;24360021;26395740;33321289;34607331;8243312", "class_list": "", "function": "Disbalance of the Duodenal Epithelial Cell Turnover and Apoptosis Accompanies Insensitivity of Intestinal Redox Homeostasis to Inhibition of the Brain Glucose-Dependent Insulinotropic Polypeptide Receptors in a Rat Model of Sporadic Alzheimer's Disease. Erratum:[Neuroendocrinology. 2023;113(5):577-578. doi: 10.1159/000528617. PMID: 37497980], [RefSeq, PubMed]; GIP-GIPR promotes neurite outgrowth of cortical neurons in Akt dependent manner., [RefSeq, PubMed]; Gipr is expressed in healthy arteries, predominantly in endothelial cells., [RefSeq, PubMed]; Glucose-dependent insulinotropic polypeptide and Glucose-dependent insulinotropic polypeptide receptors expression in the rat major salivary glands, as well as its variation in the rat SMG during the growth period, [RefSeq, PubMed]; Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor., [RefSeq, PubMed]; This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0016519 gastric inhibitory peptide receptor activity;GO:0120022 glucagon family peptide binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0032024 positive regulation of insulin secretion;GO:0051592 response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P43219-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43278-1", "uniprot_id": [ { "id": "H10_RAT", "url": "https://www.uniprot.org/uniprot/P43278", "type": "external" } ], "mass": 20885.0, "length": 194, "protein_name": "Histone H1.0", "gene_name": "H1-0", "organism": "Rat", "refseq_name": "histone H1.0", "refseq_ac": [ { "id": "NP_036710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036710", "type": "external" } ], "gene_names_uniprotkb": "H1-0; H1f0", "gene_names_refseq": "H1-0; H1f0; H1fv", "protein_names_uniprotkb": "Histone H1.0; Histone H1'; Histone H1(0)", "protein_names_refseq": "H1 histone family, member 0; Histone H1-0; histone H1'; histone H1(0); histone H1.0; histone H10", "tax_id": 10116, "disease": "", "pathway": " (rno:24437); (R-RNO-140342); (R-RNO-2559584)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "36509326;8479926", "class_list": "", "function": "Expression of Histone H1 in Rats with Traumatic Brain Injury and the Effect of the NLRP3 Inflammasome Pathway., [RefSeq, PubMed]; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0003677 DNA binding;GO:0003690 double-stranded DNA binding;GO:0031490 chromatin DNA binding;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0016604 nuclear body;GO:0000785 chromatin", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P43278-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43424-1", "uniprot_id": [ { "id": "GALT_RAT", "url": "https://www.uniprot.org/uniprot/P43424", "type": "external" } ], "mass": 43314.0, "length": 379, "protein_name": "Galactose-1-phosphate uridylyltransferase", "gene_name": "Galt", "organism": "Rat", "refseq_name": "galactose-1-phosphate uridylyltransferase", "refseq_ac": [ { "id": "NP_001013107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013107", "type": "external" } ], "gene_names_uniprotkb": "Galt", "gene_names_refseq": "Galt", "protein_names_uniprotkb": "Galactose-1-phosphate uridylyltransferase; 2.7.7.12; Gal-1-P uridylyltransferase; UDP-glucose--hexose-1-phosphate uridylyltransferase", "protein_names_refseq": "UDP-glucose--hexose-1-phosphate uridylyltransferase; gal-1-P uridylyltransferase; galactose-1-phosphate uridyl transferase; galactose-1-phosphate uridylyltransferase", "tax_id": 10116, "disease": "classic galactosemia (Disease Ontology:DOID:0111459); galactosemia (Disease Ontology:DOID:9870)", "pathway": " (rno:298003); (R-RNO-70370)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "31845342;32882063;34964137;8400361", "class_list": "", "function": "A galactose-1-phosphate uridylyltransferase-null rat model of classic galactosemia mimics relevant patient outcomes and reveals tissue-specific and longitudinal differences in galactose metabolism., [RefSeq, PubMed]; A pilot study of neonatal GALT gene replacement using AAV9 dramatically lowers galactose metabolites in blood, liver, and brain and minimizes cataracts in GALT-null rat pups., [RefSeq, PubMed]; Neonatal GALT gene replacement offers metabolic and phenotypic correction through early adulthood in a rat model of classic galactosemia., [RefSeq, PubMed]; Plays an important role in galactose metabolism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KM61", "ec_number_list": [ { "id": "2.7.7.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0061623 glycolytic process from galactose;GO:0001889 liver development;GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway;GO:0006011 UDP-alpha-D-glucose metabolic process;GO:0006012 galactose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P43424-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43425-1", "uniprot_id": [ { "id": "GBG7_RAT", "url": "https://www.uniprot.org/uniprot/P43425", "type": "external" } ], "mass": 7524.0, "length": 68, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7", "gene_name": "Gng7", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7", "refseq_ac": [ { "id": "NP_077052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077052", "type": "external" } ], "gene_names_uniprotkb": "Gng7; Gngt7", "gene_names_refseq": "Gng7; Hg3b", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7", "protein_names_refseq": "guanine nucleotide binding protein (G protein), gamma 7 subunit; guanine nucleotide binding protein, gamma 7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7; heterotrimeric guanine nucleotide-binding protein 3b", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:58979); (R-RNO-1296041); (R-RNO-202040); (R-RNO-381676); (R-RNO-392170); (R-RNO-392451); (R-RNO-400042); (R-RNO-4086398); (R-RNO-416476); (R-RNO-418594); (R-RNO-418597); (R-RNO-420092); (R-RNO-428930); (R-RNO-432040); (R-RNO-456926); (R-RNO-8964616); (R-RNO-9856530); (R-RNO-997272)", "pathway_count": 18, "publication_count": 2, "publication_id_list": "30864685;7807587", "class_list": "", "function": "GNG7 silencing repressed apoptosis and enhanced the proliferation and differentiation of placental cytotrophoblasts in preeclampsia rats through activation of the mTOR signaling pathway., [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilization of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q45QK4", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding", "go_cellular_component": "GO:0030672 synaptic vesicle membrane;GO:0005834 heterotrimeric G-protein complex;GO:0098685 Schaffer collateral - CA1 synapse;GO:0098688 parallel fiber to Purkinje cell synapse", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P43425-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43429-1", "uniprot_id": [ { "id": "GATA1_RAT", "url": "https://www.uniprot.org/uniprot/P43429", "type": "external" } ], "mass": 42871.0, "length": 413, "protein_name": "Erythroid transcription factor", "gene_name": "Gata1", "organism": "Rat", "refseq_name": "erythroid transcription factor", "refseq_ac": [ { "id": "NP_036896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036896", "type": "external" } ], "gene_names_uniprotkb": "Gata1", "gene_names_refseq": "Eryf1; Gata1", "protein_names_uniprotkb": "Erythroid transcription factor; Eryf1; GATA-1; GATA-binding factor 1; GF-1; NF-E1 DNA-binding protein", "protein_names_refseq": "GATA-1; GATA-binding factor 1; GATA-binding protein 1 (globin transcription factor 1); GF-1; NF-E1 DNA-binding protein; erythroid transcription factor", "tax_id": 10116, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); congenital nonspherocytic hemolytic anemia 9 (Disease Ontology:DOID:0051008); transient myeloproliferative syndrome (Disease Ontology:DOID:0060888); myeloid leukemia associated with Down Syndrome (Disease Ontology:DOID:0080798); X-linked thrombocytopenia with beta-thalassemia (Disease Ontology:DOID:0111767); X-linked dyserythropoietic anemia (Disease Ontology:DOID:0112156); beta thalassemia (Disease Ontology:DOID:12241); lung cancer (Disease Ontology:DOID:1324); major depressive disorder (Disease Ontology:DOID:1470); thrombocytopenia (Disease Ontology:DOID:1588); depressive disorder (Disease Ontology:DOID:1596); colon adenocarcinoma (Disease Ontology:DOID:234); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); myelofibrosis (Disease Ontology:DOID:4971); polycythemia (Disease Ontology:DOID:8432); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:25172); (R-RNO-8936459); (R-RNO-8939236); (R-RNO-983231)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "34890016;35674159;7957872", "class_list": "", "function": "GATA1 regulates the microRNA3283p/PIM1 axis via circular RNA ITGB1 to promote renal ischemia/reperfusion injury in HK2 cells., [RefSeq, PubMed]; Targeting GATA1 and p2x7r Locus Binding in Spinal Astrocytes Suppresses Chronic Visceral Pain by Promoting DNA Demethylation., [RefSeq, PubMed]; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0005667 transcription regulator complex;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0010724 regulation of definitive erythrocyte differentiation;GO:0035162 embryonic hemopoiesis;GO:0010725 regulation of primitive erythrocyte differentiation;GO:0030221 basophil differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P43429-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46413-1", "uniprot_id": [ { "id": "GSHB_RAT", "url": "https://www.uniprot.org/uniprot/P46413", "type": "external" } ], "mass": 52345.0, "length": 474, "protein_name": "Glutathione synthetase", "gene_name": "Gss", "organism": "Rat", "refseq_name": "glutathione synthetase", "refseq_ac": [ { "id": "NP_037094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037094", "type": "external" } ], "gene_names_uniprotkb": "Gss", "gene_names_refseq": "Gss", "protein_names_uniprotkb": "Glutathione synthetase; 6.3.2.3; GSH synthetase; GSH-S; Glutathione synthase", "protein_names_refseq": "GSH synthetase; GSH-S; glutathione synthase; glutathione synthetase", "tax_id": 10116, "disease": "glutathione synthetase deficiency (Disease Ontology:DOID:0080699); glutatione synthetase deficiency with 5-oxoprolinuria (Disease Ontology:DOID:0081034); congenital nonspherocytic hemolytic anemia 6 (Disease Ontology:DOID:0112252); Alzheimer's disease (Disease Ontology:DOID:10652); Huntington's disease (Disease Ontology:DOID:12858); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (rno:25458); (R-RNO-174403)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "7862666", "class_list": "", "function": "Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7862666). Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:7862666). Participates in ophthalmate biosynthesis in hepatocytes (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.3", "type": "external" } ], "go_molecular_function": "GO:0004363 glutathione synthase activity;GO:0043295 glutathione binding;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0034612 response to tumor necrosis factor;GO:0031667 response to nutrient levels;GO:0046686 response to cadmium ion;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P46413-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48508-1", "uniprot_id": [ { "id": "GSH0_RAT", "url": "https://www.uniprot.org/uniprot/P48508", "type": "external" } ], "mass": 30548.0, "length": 274, "protein_name": "Glutamate--cysteine ligase regulatory subunit", "gene_name": "Gclm", "organism": "Rat", "refseq_name": "glutamate--cysteine ligase regulatory subunit", "refseq_ac": [ { "id": "NP_059001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059001", "type": "external" } ], "gene_names_uniprotkb": "Gclm; Glclr", "gene_names_refseq": "Gclm; Glclr", "protein_names_uniprotkb": "Glutamate--cysteine ligase regulatory subunit; GCS light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; Glutamate--cysteine ligase modifier subunit", "protein_names_refseq": "GCS light chain; gamma-ECS regulatory subunit; gamma-glutamylcysteine synthetase regulatory subunit; glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory; glutamate--cysteine ligase regulatory subunit", "tax_id": 10116, "disease": "myocardial infarction (Disease Ontology:DOID:5844); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (rno:29739); (R-RNO-174403)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "22673903;24557597;27998794;8104188", "class_list": "", "function": "Study determined the effects of troxerutin on cognitive deficits and glutamate cysteine ligase subunits (GCLM and GCLC) in the hippocampus of streptozotocin-induced type 1 diabetes mellitus rat: troxerutin alleviates oxidative stress and promotes learning potential in STZ-induced diabetic rats likely through GCL mechanisms, especially that of GCLC., [RefSeq, PubMed]; Upregulation of both GCLC and GLCM mRNA levels in response to cysteine deprivation was dependent on new protein synthesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035226 glutamate-cysteine ligase catalytic subunit binding;GO:0046982 protein heterodimerization activity;GO:0004357 glutamate-cysteine ligase activity;GO:1990609 glutamate-cysteine ligase regulator activity", "go_cellular_component": "GO:0017109 glutamate-cysteine ligase complex", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0051900 regulation of mitochondrial depolarization;GO:0097069 cellular response to thyroxine stimulus;GO:0035733 hepatic stellate cell activation;GO:0006536 glutamate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P48508-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49000-1", "uniprot_id": [ { "id": "AMH_RAT", "url": "https://www.uniprot.org/uniprot/P49000", "type": "external" } ], "mass": 58889.0, "length": 553, "protein_name": "Anti-Muellerian hormone", "gene_name": "Amh", "organism": "Rat", "refseq_name": "anti-Muellerian hormone precursor", "refseq_ac": [ { "id": "NP_037034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037034", "type": "external" } ], "gene_names_uniprotkb": "Amh", "gene_names_refseq": "Amh; MIS", "protein_names_uniprotkb": "Anti-Muellerian hormone; AMH; MIS; Muellerian-inhibiting factor; Muellerian-inhibiting substance", "protein_names_refseq": "Anti - Mullerian hormone (Mulerian inhibiting substance); anti-Muellerian hormone precursor; anti-Muellerian hormone; muellerian-inhibiting factor; muellerian-inhibiting substance", "tax_id": 10116, "disease": "persistent Mullerian duct syndrome (Disease Ontology:DOID:0050791); polycystic ovary syndrome (Disease Ontology:DOID:11612); breast cancer (Disease Ontology:DOID:1612); disorder of sexual development (Disease Ontology:DOID:1923); granulosa cell tumor (Disease Ontology:DOID:2999); ovarian carcinoma (Disease Ontology:DOID:4001); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25378); (R-RNO-201451)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1572639;31724927;32387527;33709094;37633225;7588229", "class_list": "", "function": "Effects of Ovarian Transplant on Anti-Mullerian Hormone, Kisspeptin-1, and Kisspeptin-1 Receptor Levels in Rats., [RefSeq, PubMed]; Mechanisms of DHEA-induced AMH increase in the ovarian tissues of PCOS rat., [RefSeq, PubMed]; Ovarian follicles are resistant to monocyte perturbations-implications for ovarian health with immune disruptiondagger., [RefSeq, PubMed]; Role of non-classical effects of testosterone and epitestosterone on AMH balance and testicular development parameters., [RefSeq, PubMed]; The anti-Muellerian hormone (AMH) plays an important role in several reproductive functions (By similarity). Anti-Muellerian hormone binds and activates AMHR2, its specific type-II receptor, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A) to regulate target gene expression through downstream SMAD protein signal transduction (By similarity). Produced and secreted by Sertoli cells of the male fetus, anti-Muellerian hormone induces Muellerian duct regression during male fetal sexual differentiation (By similarity). In female, it is produced by granulosa cells of the preantral and small antral follicles and acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles (By similarity). Also plays a role in Leydig cell differentiation and function (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005160 transforming growth factor beta receptor binding;GO:0008083 growth factor activity;GO:0005114 type II transforming growth factor beta receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0007530 sex determination;GO:2000355 negative regulation of ovarian follicle development;GO:0010628 positive regulation of gene expression;GO:0001655 urogenital system development;GO:0001541 ovarian follicle development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P49000-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49218-1", "uniprot_id": [ { "id": "MTR1A_RAT", "url": "https://www.uniprot.org/uniprot/P49218", "type": "external" } ], "mass": 18214.0, "length": 156, "protein_name": "Melatonin receptor type 1A", "gene_name": "Mtnr1a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mtnr1a", "gene_names_refseq": "", "protein_names_uniprotkb": "Melatonin receptor type 1A; Mel-1A-R; Mel1a receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "idiopathic juvenile osteoporosis (Disease Ontology:DOID:12559); Huntington's disease (Disease Ontology:DOID:12858); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7946354", "class_list": "", "function": "High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Possibly involved in sleep induction, by melatonin activation of the potassium channel KCNMA1/BK and the dissociation of G-beta and G-gamma subunits, thereby decreasing synaptic transmission (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042562 hormone binding;GO:0008502 melatonin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043235 receptor complex", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0046676 negative regulation of insulin secretion;GO:0007623 circadian rhythm;GO:0043010 camera-type eye development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P49218-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49287-1", "uniprot_id": [ { "id": "MTR1B_RAT", "url": "https://www.uniprot.org/uniprot/P49287", "type": "external" } ], "mass": 40194.0, "length": 364, "protein_name": "Melatonin receptor type 1B", "gene_name": "Mtnr1b", "organism": "Rat", "refseq_name": "melatonin receptor type 1B precursor", "refseq_ac": [ { "id": "NP_001380770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001380770", "type": "external" } ], "gene_names_uniprotkb": "Mtnr1b; Mt2", "gene_names_refseq": "Mel1b-r; Mt2; Mtnr1b", "protein_names_uniprotkb": "Melatonin receptor type 1B; Mel-1B-R; Mel1b receptor", "protein_names_refseq": "mel-1B-R; mel1b melatonin receptor; mel1b receptor; melatonin receptor type 1B precursor; melatonin receptor type 1B", "tax_id": 10116, "disease": "acute pancreatitis (Disease Ontology:DOID:2913); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:192646); (R-RNO-373076); (R-RNO-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12000116;19340560;25714375;26162699;26884304;28377323;7568007", "class_list": "", "function": "An inhibitory effect of melatonin on oxytocin secretion from the rat hypothalamo-neurohypophysial system is mediated through a subtype MT1 membrane receptor and its action is independent of subtype MT2 receptor. However, for the stimulatory effect of pharmacological concentration of the pineal hormone on oxytocin release, probably mechanisms other than membrane MT1/MT2 receptor(s)-dependent are involved., [RefSeq, PubMed]; High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity., [UniProtKB]; Since binding sites for melatonin have been found in the hippocampus of several mammals, it has been suggested that the pineal hormone melatonin is able to modulate neuronal functions of hippocampal cells, [RefSeq, PubMed]; Suggest MT2 melatonin receptor may be a novel target for analgesic drug development., [RefSeq, PubMed]; TBI in rats resulted in lower levels of MT1 and MT2; replication of these findings is necessary as is evaluation of the consequences of lower receptor levels., [RefSeq, PubMed]; We demonstrated the co-existence of MT1 and MT2 receptors in all melanopsin-positive M1 ipRGCs, and the expression of MT1 and MT2 receptors in these cells could be seen as early as the day of birth (P0). Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7X946", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008502 melatonin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0051970 negative regulation of transmission of nerve impulse;GO:0007186 G protein-coupled receptor signaling pathway;GO:0043524 negative regulation of neuron apoptotic process;GO:0042593 glucose homeostasis;GO:0046676 negative regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P49287-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50233-1", "uniprot_id": [ { "id": "DHI2_RAT", "url": "https://www.uniprot.org/uniprot/P50233", "type": "external" } ], "mass": 43726.0, "length": 400, "protein_name": "11-beta-hydroxysteroid dehydrogenase type 2", "gene_name": "Hsd11b2", "organism": "Rat", "refseq_name": "11-beta-hydroxysteroid dehydrogenase type 2", "refseq_ac": [ { "id": "NP_058777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058777", "type": "external" } ], "gene_names_uniprotkb": "Hsd11b2; Hsd11k", "gene_names_refseq": "Hsd11b2", "protein_names_uniprotkb": "11-beta-hydroxysteroid dehydrogenase type 2; 1.1.1.-; 11-DH2; 11-beta-HSD2; Corticosteroid 11-beta-dehydrogenase isozyme 2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase", "protein_names_refseq": "11-DH2; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type 2; Hydroxysteroid dehydrogenase, 11 beta type 2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; corticosteroid 11-beta-dehydrogenase isozyme 2", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); hypertension (Disease Ontology:DOID:10763); apparent mineralocorticoid excess syndrome (Disease Ontology:DOID:4367); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); inherited metabolic disorder (Disease Ontology:DOID:655); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25117); (R-RNO-194002); (R-RNO-9757110)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "1312193;26403275;26798634;28320863;32978833;34028587;7649078", "class_list": "", "function": "Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as corticosterone, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as 11-dehydrocorticosterone, in the presence of NAD(+) (PubMed:7649078). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids (PubMed:34028587, PubMed:7649078). Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure (PubMed:34028587). Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen (By similarity). Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone (By similarity). Converts 7-beta-25-dihydroxycholesterol to 7-oxo-25-hydroxycholesterol in vitro (By similarity). 7-beta-25-dihydroxycholesterol (not 7-oxo-25-hydroxycholesterol) acts as a ligand for the G protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (By similarity). Catalyzes the conversion of 7-beta-hydroxycholesterol into 7-ketocholesterol (7-oxocholesterol), a precursor of 7-keto,27-hydroxycholesterol, which activates smoothened (SMO) and the smoothened signaling pathway (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Contribution of placental 11beta-HSD2 to the pathogenesis of preeclampsia., [RefSeq, PubMed]; Rac1 GTPase regulates 11beta-HSD2 expression, mineralocorticoid receptor activation, and mineralocorticoid receptor-mediated pro-fibrotic signaling., [RefSeq, PubMed]; Specific 11beta-HSD2 immunoreactivity was found in the cytoplasm of the Magnocellular Neurosecretory Cells in both the Supraoptic and Paraventricular nuclei., [RefSeq, PubMed]; Zearalenone is a selective inhibitor of HSD11B2, implying that this agent may cause excessive glucocorticoid action in local tissues such as kidney and placentas., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.146", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.146", "type": "external" }, { "id": "1.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.201", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0051287 NAD binding;GO:0005496 steroid binding;GO:0070523 11-beta-hydroxysteroid dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0001666 response to hypoxia;GO:0032094 response to food;GO:0051384 response to glucocorticoid;GO:0007565 female pregnancy;GO:0048545 response to steroid hormone", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P50233-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50545-1", "uniprot_id": [ { "id": "HCK_RAT", "url": "https://www.uniprot.org/uniprot/P50545", "type": "external" } ], "mass": 59154.0, "length": 524, "protein_name": "Tyrosine-protein kinase HCK", "gene_name": "Hck", "organism": "Rat", "refseq_name": "tyrosine-protein kinase HCK", "refseq_ac": [ { "id": "NP_037317", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037317", "type": "external" } ], "gene_names_uniprotkb": "Hck", "gene_names_refseq": "Hck; Hctk; p56Hck; p59Hck", "protein_names_uniprotkb": "Tyrosine-protein kinase HCK; 2.7.10.2; Hematopoietic cell kinase; Hemopoietic cell kinase; p56-HCK; p56Hck; p59Hck", "protein_names_refseq": "hematopoietic cell kinase; hemopoietic cell kinase; hemopoietic cell tyrosine kinase; p56-HCK; tyrosine-protein kinase HCK", "tax_id": 10116, "disease": "intestinal cancer (Disease Ontology:DOID:10155); Goldenhar syndrome (Disease Ontology:DOID:2907); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:25734); (R-RNO-2029481); (R-RNO-912631); (R-RNO-9674555); (R-RNO-9705462)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "14551197;1764064;1875927;22673903;27053350", "class_list": "", "function": "Alternate protein isoforms arise through the use of a non-AUG (CUG), and a downstream in-frame AUG translation initiation codons, in mouse and human. Same is likely true for rat as there is strong sequence conservation amongst different species., [RefSeq, PubMed]; Hck was up-regulated in neurons adjacent to the hematoma after intracerebral hemorrhage., [RefSeq, PubMed]; Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS (By similarity)., [UniProtKB, PubMed]; The protein encoded by this gene is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types.The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms in human and mouse. Based on strong sequence conservation amongst these species, this may also be true for rat. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64647;Q6AYV7", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane", "go_biological_process": "GO:0071801 regulation of podosome assembly;GO:0006954 inflammatory response;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0018108 peptidyl-tyrosine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P50545-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50573-1", "uniprot_id": [ { "id": "GBRR3_RAT", "url": "https://www.uniprot.org/uniprot/P50573", "type": "external" } ], "mass": 54031.0, "length": 464, "protein_name": "Gamma-aminobutyric acid receptor subunit rho-3", "gene_name": "Gabrr3", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid receptor subunit rho-3 precursor", "refseq_ac": [ { "id": "NP_620252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620252", "type": "external" } ], "gene_names_uniprotkb": "Gabrr3", "gene_names_refseq": "Gabrr3", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit rho-3; GABA(A) receptor subunit rho-3; GABA(C) receptor; GABAAR subunit rho-3", "protein_names_refseq": "GABA receptor rho-3 subunit; GABA(A) receptor subunit rho-3; GABA(C) receptor; GABAAR subunit rho-3; gamma-aminobutyric acid (GABA) A receptor, rho 3; gamma-aminobutyric acid (GABA) receptor, rho 3; gamma-aminobutyric acid receptor subunit rho-3 precursor; gamma-aminobutyric acid receptor subunit rho-3; gamma-aminobutyric acid type A receptor rho3 subunit", "tax_id": 10116, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:192258); (R-RNO-977443)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11861315;12431995;18201822;8605242", "class_list": "", "function": "Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (PubMed:11861315). Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces (By similarity). When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:11861315)., [UniProtKB, UniProtKB, PubMed]; The expression of GABA(C) receptors in the cerebellum adds a new dimension to the regulation of GABAergic neurotransmission, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P50573-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51657-1", "uniprot_id": [ { "id": "DHB1_RAT", "url": "https://www.uniprot.org/uniprot/P51657", "type": "external" } ], "mass": 36967.0, "length": 344, "protein_name": "Estradiol 17-beta-dehydrogenase 1", "gene_name": "Hsd17b1", "organism": "Rat", "refseq_name": "estradiol 17-beta-dehydrogenase 1", "refseq_ac": [ { "id": "NP_036983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036983", "type": "external" } ], "gene_names_uniprotkb": "Hsd17b1; Edh17b1", "gene_names_refseq": "17BHD1; Hsd17b1", "protein_names_uniprotkb": "Estradiol 17-beta-dehydrogenase 1; 1.1.1.62; 17-beta-HSD 1; 17-beta-hydroxysteroid dehydrogenase type 1", "protein_names_refseq": "17-beta-HSD 1; 17-beta-hydroxysteroid dehydrogenase type 1; Hydroxysteroid dehydrogenase 17 beta, type 1; estradiol 17-beta-dehydrogenase 1", "tax_id": 10116, "disease": "invasive ductal carcinoma (Disease Ontology:DOID:3008)", "pathway": " (rno:25322); (R-RNO-193144)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "34038751;7925110;8612487;9524272", "class_list": "", "function": "Favors the reduction of estrogens and androgens. Uses preferentially NADH., [UniProtKB]; Gonadal sex steroid hormone secretion after exposure of male rats to estrogenic chemicals and their combinations., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.64", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" } ], "go_molecular_function": "GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:0042803 protein homodimerization activity;GO:0005496 steroid binding;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0036094 small molecule binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0060612 adipose tissue development;GO:0007040 lysosome organization;GO:0006703 estrogen biosynthetic process;GO:0060348 bone development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P51657-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51839-1", "uniprot_id": [ { "id": "GUC2D_RAT", "url": "https://www.uniprot.org/uniprot/P51839", "type": "external" } ], "mass": 122093.0, "length": 1110, "protein_name": "Guanylate cyclase 2D", "gene_name": "Gucy2d", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gucy2d; Gucy2e", "gene_names_refseq": "", "protein_names_uniprotkb": "Guanylate cyclase 2D; 4.6.1.2; GC-D; Guanylate cyclase, olfactory; ONE-GC; Olfactory guanylyl cyclase GC-D", "protein_names_refseq": "", "tax_id": 10116, "disease": "Leber congenital amaurosis (Disease Ontology:DOID:14791)", "pathway": " (rno:113911)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11580282;18178149;7724600", "class_list": "", "function": "Functions as an olfactory receptor activated by a urine odorant, uroguanylin (PubMed:18178149). Activated as well by the volatile semiochemicals carbon disulfide (CS2) and carbon dioxide (CO2) (By similarity). Has guanylate cyclase activity upon binding of the ligand (PubMed:18178149). Activation of GUCY2D neurons leads to the cGMP-dependent activation of the CNGA3 channels, membrane depolarization and an increase in action potential frequency. Signaling pathways activated by GUCY2D may trigger social behaviors such as acquisition of food preference (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F1M245", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0016941 natriuretic peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0097730 non-motile cilium;GO:0060170 ciliary membrane", "go_biological_process": "GO:0042048 olfactory behavior;GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007168 receptor guanylyl cyclase signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P51839-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51840-1", "uniprot_id": [ { "id": "GUC2E_RAT", "url": "https://www.uniprot.org/uniprot/P51840", "type": "external" } ], "mass": 120801.0, "length": 1108, "protein_name": "Retinal guanylyl cyclase 1", "gene_name": "Gucy2e", "organism": "Rat", "refseq_name": "retinal guanylyl cyclase 1 precursor", "refseq_ac": [ { "id": "NP_077356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077356", "type": "external" } ], "gene_names_uniprotkb": "Gucy2e; Guc2e; Gucy2d", "gene_names_refseq": "Gucy2d; Gucy2e; RETGC-1", "protein_names_uniprotkb": "Retinal guanylyl cyclase 1; 4.6.1.2; Guanylate cyclase 2E; Guanylyl cyclase GC-E; RETGC-1", "protein_names_refseq": "guanylate cyclase 2D, membrane (retina-specific); guanylate cyclase 2D, retinal; guanylyl cyclase 2e; guanylyl cyclase GC-E; retinal guanylyl cyclase 1 precursor; retinal guanylyl cyclase 1", "tax_id": 10116, "disease": "congenital stationary night blindness (Disease Ontology:DOID:0050534); Leber congenital amaurosis 1 (Disease Ontology:DOID:0110078); cone-rod dystrophy 6 (Disease Ontology:DOID:0111011); retinitis pigmentosa (Disease Ontology:DOID:10584); choroidal sclerosis (Disease Ontology:DOID:980)", "pathway": " (rno:79222); (R-RNO-2514859)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "7831337;9153227", "class_list": "", "function": "Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-associated proteins to the photoreceptor outer segment membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0001750 photoreceptor outer segment;GO:0042622 photoreceptor outer segment membrane;GO:0120202 rod photoreceptor disc membrane", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007601 visual perception;GO:0007168 receptor guanylyl cyclase signaling pathway;GO:0046068 cGMP metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P51840-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52287-1", "uniprot_id": [ { "id": "GBB3_RAT", "url": "https://www.uniprot.org/uniprot/P52287", "type": "external" } ], "mass": 37180.0, "length": 340, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3", "gene_name": "Gnb3", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3", "refseq_ac": [ { "id": "NP_068630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068630", "type": "external" } ], "gene_names_uniprotkb": "Gnb3", "gene_names_refseq": "Gnb3; Hg2d", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Transducin beta chain 3", "protein_names_refseq": "G protein beta-subunit; guanine nucleotide binding protein (G protein), beta 3; guanine nucleotide binding protein (G protein), beta polypeptide 3; guanine nucleotide binding protein, beta 3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; guanine nucleotide-binding protein, beta-3 subunit; heterotrimeric guanine nucleotide-binding protein 2d; transducin beta chain 3", "tax_id": 10116, "disease": "congenital stationary night blindness 1H (Disease Ontology:DOID:0110866); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); familial hyperlipidemia (Disease Ontology:DOID:1168); depressive disorder (Disease Ontology:DOID:1596); carotid artery disease (Disease Ontology:DOID:3407); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:60449); (R-RNO-1296041); (R-RNO-202040); (R-RNO-381676); (R-RNO-392170); (R-RNO-392451); (R-RNO-400042); (R-RNO-4086398); (R-RNO-416476); (R-RNO-418594); (R-RNO-418597); (R-RNO-420092); (R-RNO-428930); (R-RNO-432040); (R-RNO-456926); (R-RNO-6814122); (R-RNO-8964616); (R-RNO-9717207); (R-RNO-9856530); (R-RNO-997272)", "pathway_count": 20, "publication_count": 1, "publication_id_list": "7959013", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030507 spectrin binding;GO:0051020 GTPase binding;GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0044297 cell body;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0090181 regulation of cholesterol metabolic process;GO:0010906 regulation of glucose metabolic process;GO:0006884 cell volume homeostasis;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P52287-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52500-1", "uniprot_id": [ { "id": "GRPR_RAT", "url": "https://www.uniprot.org/uniprot/P52500", "type": "external" } ], "mass": 43236.0, "length": 384, "protein_name": "Gastrin-releasing peptide receptor", "gene_name": "Grpr", "organism": "Rat", "refseq_name": "gastrin-releasing peptide receptor", "refseq_ac": [ { "id": "NP_036838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036838", "type": "external" } ], "gene_names_uniprotkb": "Grpr", "gene_names_refseq": "Grpr", "protein_names_uniprotkb": "Gastrin-releasing peptide receptor; GRP-R; GRP-preferring bombesin receptor", "protein_names_refseq": "GRP-R; GRP-preferring bombesin receptor; gastrin-releasing peptide receptor", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder 75 (Disease Ontology:DOID:0061048); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:24938); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "22735756;26855425;33059246;37604300;8391296", "class_list": "", "function": "GRPR down-regulation inhibits spermatogenesis through Ca[2+] mediated by PLCbeta/IP3R signaling pathway in long-term formaldehyde-exposed rats., [RefSeq, PubMed]; Peptidergic pathways comprise the core of a sigh control circuit that integrates physiological and perhaps emotional input to transform normal breaths into sighs, [RefSeq, PubMed]; Receptor for gastrin-releasing peptide (GRP) (PubMed:8391296). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide-expressing cells which leads to enhanced auditory fear memories (By similarity). Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425)., [UniProtKB, UniProtKB, PubMed, PubMed]; These findings highlight the role of GRPR signaling in sepsis outcome. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "G3V6I7", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity;GO:0008188 neuropeptide receptor activity;GO:0004946 bombesin receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007611 learning or memory;GO:0042127 regulation of cell population proliferation;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0035176 social behavior", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P52500-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52909-1", "uniprot_id": [ { "id": "JUND_RAT", "url": "https://www.uniprot.org/uniprot/P52909", "type": "external" } ], "mass": 34875.0, "length": 341, "protein_name": "Transcription factor JunD", "gene_name": "Jund", "organism": "Rat", "refseq_name": "transcription factor JunD isoform deltaJunD", "refseq_ac": [ { "id": "NP_001273895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273895", "type": "external" } ], "gene_names_uniprotkb": "Jund; Jun-d", "gene_names_refseq": "Jund", "protein_names_uniprotkb": "Transcription factor JunD; Transcription factor AP-1 subunit JunD", "protein_names_refseq": "jun D proto-oncogene; transcription factor AP-1 subunit JunD; transcription factor JunD isoform deltaJunD; transcription factor JunD; transcription factor jun-D", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); crescentic glomerulonephritis (Disease Ontology:DOID:13139); transient cerebral ischemia (Disease Ontology:DOID:224); renal carcinoma (Disease Ontology:DOID:4451); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:24518)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12105216;22673903;25788572;7875605", "class_list": "", "function": "JunD activates miR-29b by enhancing its transcription and processing, which contribute to the inhibitory effect of JunD, [RefSeq, PubMed]; The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]., [RefSeq]; Transcription factor binding AP-1 sites (By similarity). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (By similarity)., [UniProtKB, UniProtKB]; Translation initiation from alternative AUG and non-AUG sites in human, mouse and rat., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0005667 transcription regulator complex;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0009409 response to cold;GO:0032496 response to lipopolysaccharide;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P52909-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54313-1", "uniprot_id": [ { "id": "GBB2_RAT", "url": "https://www.uniprot.org/uniprot/P54313", "type": "external" } ], "mass": 37331.0, "length": 340, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2", "gene_name": "Gnb2", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2", "refseq_ac": [ { "id": "NP_112299", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112299", "type": "external" } ], "gene_names_uniprotkb": "Gnb2", "gene_names_refseq": "Gnb2; Hg2c1", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; G protein subunit beta-2; Transducin beta chain 2", "protein_names_refseq": "g protein subunit beta-2; guanine nucleotide binding protein (G protein), beta 2; guanine nucleotide binding protein (G protein), beta polypeptide 2; guanine nucleotide binding protein beta 2 subunit; guanine nucleotide binding protein, beta polypeptide 2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; guanine nucleotide-binding protein, beta 2; heterotrimeric guanine nucleotide-binding protein 2c1; transducin beta chain 2", "tax_id": 10116, "disease": "", "pathway": " (rno:81667); (R-RNO-1296041); (R-RNO-202040); (R-RNO-381676); (R-RNO-392170); (R-RNO-392451); (R-RNO-400042); (R-RNO-4086398); (R-RNO-416476); (R-RNO-418594); (R-RNO-418597); (R-RNO-420092); (R-RNO-428930); (R-RNO-432040); (R-RNO-456926); (R-RNO-6814122); (R-RNO-8964616); (R-RNO-9856530); (R-RNO-997272)", "pathway_count": 19, "publication_count": 6, "publication_id_list": "10970423;21633701;22711958;22905384;24513289;38843836", "class_list": "", "function": "Analysis of enhanced expression of heterotrimeric GTP-binding protein subunits in Zajdela ascitic hepatoma, [RefSeq, PubMed]; Data indicate that verexpression of Gbeta2 subunit mimics CaV2.2 kinetic slowing by noradrenaline., [RefSeq, PubMed]; Data show that the C-terminus of SNAP-25 is a binding target for Gbetagamma necessary for both transient transmitter-mediated presynaptic inhibition, and the induction of presynaptic LTD., [RefSeq, PubMed]; Gnb2 and Gnb4 participate in the opioid and adrenergic receptor-mediated Ca2+ channel modulation in rat sympathetic neurons, [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q71SU9", "ec_number_list": [], "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0044877 protein-containing complex binding;GO:0051020 GTPase binding;GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0048471 perinuclear region of cytoplasm;GO:0044297 cell body", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P54313-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54842-1", "uniprot_id": [ { "id": "MAFB_RAT", "url": "https://www.uniprot.org/uniprot/P54842", "type": "external" } ], "mass": 35792.0, "length": 323, "protein_name": "Transcription factor MafB", "gene_name": "Mafb", "organism": "Rat", "refseq_name": "transcription factor MafB", "refseq_ac": [ { "id": "NP_062189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062189", "type": "external" } ], "gene_names_uniprotkb": "Mafb; Maf1", "gene_names_refseq": "Krml; Mafb; b-maf", "protein_names_uniprotkb": "Transcription factor MafB; Maf-B; Transcription factor Maf-1; V-maf musculoaponeurotic fibrosarcoma oncogene homolog B", "protein_names_refseq": "Kreisler maf-related leucine zipper homolog (b-maf); maf-B; transcription factor Maf-1; transcription factor MafB; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B", "tax_id": 10116, "disease": "Duane retraction syndrome 3 (Disease Ontology:DOID:0061029); multicentric carpotarsal osteolysis syndrome (Disease Ontology:DOID:0111534); Duane retraction syndrome (Disease Ontology:DOID:12557)", "pathway": " (rno:54264)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "22673903;22961837;26108485;9038383;9375588;9571165", "class_list": "", "function": "Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context (By similarity). Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The chronic culture of the rat beta-cell line resulted in partial DNA demethylation of the MafB promoter., [RefSeq, PubMed]; These results support a role for MafB as a regulator of chondrocyte gene expression and matrix formation via control of aggrecan, MMP3 and MMP13 expression, and indicate an important role for RA in the regulation of MafB, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0021571 rhombomere 5 development;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007584 response to nutrient", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P54842-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57097-1", "uniprot_id": [ { "id": "MERTK_RAT", "url": "https://www.uniprot.org/uniprot/P57097", "type": "external" } ], "mass": 109423.0, "length": 994, "protein_name": "Tyrosine-protein kinase Mer", "gene_name": "Mertk", "organism": "Rat", "refseq_name": "tyrosine-protein kinase Mer precursor", "refseq_ac": [ { "id": "NP_075232", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075232", "type": "external" } ], "gene_names_uniprotkb": "Mertk; Mer", "gene_names_refseq": "Mertk; rdy", "protein_names_uniprotkb": "Tyrosine-protein kinase Mer; 2.7.10.1; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK", "protein_names_refseq": "Receptor tyrosine tinase gene probably the gene for Rdy; c-mer proto-oncogene tyrosine kinase; proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; receptor tyrosine kinase MerTK; retinal dystrophy; tyrosine-protein kinase Mer precursor; tyrosine-protein kinase Mer", "tax_id": 10116, "disease": "retinitis pigmentosa 38 (Disease Ontology:DOID:0110367); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:65037); (R-RNO-202733)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10699188;30054542;34440696;34829984;38588709;38783191", "class_list": "", "function": "Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore Phagocytic Capacity to Retinal Pigment Epithelium Lacking the Engulfment Receptor MerTK. Publication Status: Online-Only, [RefSeq, PubMed]; MERTK in the rat trigeminal system: a potential novel target for cluster headache? Publication Status: Online-Only, [RefSeq, PubMed]; Protective Role of MerTK in Diabetic Peripheral Neuropathy via Inhibition of the NF-kappaB Signaling Pathway., [RefSeq, PubMed]; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 (By similarity)., [UniProtKB]; Study of the Role of the Tyrosine Kinase Receptor MerTK in the Development of Kidney Ischemia-Reperfusion Injury in RCS Rats. Publication Status: Online-Only, [RefSeq, PubMed]; The long-term preservation of photoreceptors we observed indicates that MERTK-related form of inherited retinal degeneration, which has currently no cure, could be amenable to laser therapy or subretinal surgery, to extend the visual function, potentially for life. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 15, "predicted_n_glycosites": 14, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0006468 protein phosphorylation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007283 spermatogenesis;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P57097-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60522-1", "uniprot_id": [ { "id": "GBRL2_RAT", "url": "https://www.uniprot.org/uniprot/P60522", "type": "external" } ], "mass": 13667.0, "length": 117, "protein_name": "Gamma-aminobutyric acid receptor-associated protein-like 2", "gene_name": "Gabarapl2", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid receptor-associated protein-like 2", "refseq_ac": [ { "id": "NP_073197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073197", "type": "external" } ], "gene_names_uniprotkb": "Gabarapl2; Gef2", "gene_names_refseq": "Gabarapl2; Gef2", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor-associated protein-like 2; GABA(A) receptor-associated protein-like 2; GATE-16; GEF-2; Ganglioside expression factor 2; Golgi-associated ATPase enhancer of 16 kDa", "protein_names_refseq": "GABA(A) receptor-associated protein like 2; GATE-16; GEF-2; gamma-aminobutyric acid receptor-associated protein-like 2; ganglioside expression factor 2; golgi-associated ATPase enhancer of 16 kDa", "tax_id": 10116, "disease": "", "pathway": " (rno:64670); (R-RNO-1632852); (R-RNO-8854214)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08765;Q9DCP8;Q9UQF7", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0008429 phosphatidylethanolamine binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0070972 protein localization to endoplasmic reticulum;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P60522-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60924-1", "uniprot_id": [ { "id": "DELE1_RAT", "url": "https://www.uniprot.org/uniprot/P60924", "type": "external" } ], "mass": 55208.0, "length": 509, "protein_name": "DAP3-binding cell death enhancer 1", "gene_name": "Dele1", "organism": "Rat", "refseq_name": "DAP3-binding cell death enhancer 1", "refseq_ac": [ { "id": "NP_955787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955787", "type": "external" } ], "gene_names_uniprotkb": "Dele1; Dele", "gene_names_refseq": "DELE1(L); Dele1; Dele; RGD735029", "protein_names_uniprotkb": "DAP3-binding cell death enhancer 1; DAP3-binding cell death enhancer 1, long form; DELE1(L); Death ligand signal enhancer", "protein_names_refseq": "DAP3-binding cell death enhancer 1, long form; DAP3-binding cell death enhancer 1; SEL1 domain containing protein RGD735029; death ligand signal enhancer", "tax_id": 10116, "disease": "", "pathway": " (rno:307480); (R-RNO-9840373)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "20563667", "class_list": "", "function": "Functionally characterizes the human homolog as a DAP3-binding protein involved in apoptosis mediated by death receptors., [RefSeq, PubMed]; Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI (By similarity). It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR (By similarity). Also acts as an activator of PRKN-independent mitophagy: activates the protein kinase activity of EIF2AK1/HRI in response to mitochondrial damage, promoting eIF-2-alpha (EIF2S1) phosphorylation, leading to mitochondrial localization of EIF2S1 followed by induction of mitophagy (By similarity)., [UniProtKB, UniProtKB]; Protein kinase activator that activates the ISR in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting DELE1 localization at the mitochondrial surface, where it binds and activates EIF2AK1/HRI to trigger the ISR., [UniProtKB, UniProtKB]; Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency, mitochondrial stress or mitochondrial DNA breaks. Detects impaired protein import and processing in mitochondria, activating the ISR. May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V8I7", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0051260 protein homooligomerization;GO:0006974 DNA damage response;GO:0033554 cellular response to stress;GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P60924-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61149-1", "uniprot_id": [ { "id": "FGF1_RAT", "url": "https://www.uniprot.org/uniprot/P61149", "type": "external" } ], "mass": 17418.0, "length": 155, "protein_name": "Fibroblast growth factor 1", "gene_name": "Fgf1", "organism": "Rat", "refseq_name": "fibroblast growth factor 1", "refseq_ac": [ { "id": "NP_036978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036978", "type": "external" } ], "gene_names_uniprotkb": "Fgf1; Fgf-1; Fgfa", "gene_names_refseq": "FGF-1; Fgf1; Fgf2b; HBGF-1; HBGF1", "protein_names_uniprotkb": "Fibroblast growth factor 1; Acidic fibroblast growth factor; FGF-1; HBGF-1; Heparin-binding growth factor 1; aFGF", "protein_names_refseq": "Fibroblast growth factor 1 (heparin binding); aFGF; acidic fibroblast growth factor; fibroblast growth factor 1 (acidic); fibroblast growth factor 1; fibroblast growth factor 2b; heparin-binding growth factor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:25317); (R-RNO-109704); (R-RNO-1257604); (R-RNO-190322); (R-RNO-190370); (R-RNO-190371); (R-RNO-190372); (R-RNO-190373); (R-RNO-190375); (R-RNO-190377); (R-RNO-5654219); (R-RNO-5654221); (R-RNO-5654227); (R-RNO-5654228); (R-RNO-5654687); (R-RNO-5654688); (R-RNO-5654689); (R-RNO-5654693); (R-RNO-5654695); (R-RNO-5654699); (R-RNO-5654700); (R-RNO-5654704); (R-RNO-5654706); (R-RNO-5654710); (R-RNO-5654712); (R-RNO-5654719); (R-RNO-5654720); (R-RNO-5654726); (R-RNO-5654727); (R-RNO-5654732); (R-RNO-5654733); (R-RNO-5673001); (R-RNO-6811558)", "pathway_count": 33, "publication_count": 10, "publication_id_list": "15627653;17277441;18540049;22673903;2470029;28298517;28795363;28813681;32360543;35477223", "class_list": "", "function": "FGF-1 modulates pancreatic beta-cell functions/metabolism: An in vitro study., [RefSeq, PubMed]; FGF1-overexpressed adipose-derived mesenchymal stem induce neuroprotection and functional recovery in a rat stroke model., [RefSeq, PubMed]; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis., [UniProtKB, UniProtKB]; Secreted key regulators (Fgf1, Bmp4, Gdf3) are expressed by PAC1-immunopositive retinal ganglion cells in the postnatal rat retina. Publication Status: Online-Only, [RefSeq, PubMed]; Suboptimal FGFR activation by a weak FGF1-FGFR dimer is sufficient to evoke a metabolic response, whereas full FGFR activation by stable and sustained dimerization is required to elicit a mitogenic response., [RefSeq, PubMed]; This is the first time a comprehensive subset of proteins involved in FGF inhibitory response is defined. We were able to identify a number of targets and specifically discover glycogen synthase kinase3beta (GSK3beta) as a novel key mediator of FGF inhibitory response in chondrocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P10935", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0044548 S100 protein binding;GO:0008083 growth factor activity;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:0001759 organ induction;GO:1903672 positive regulation of sprouting angiogenesis;GO:0001525 angiogenesis;GO:0001934 positive regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P61149-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61954-1", "uniprot_id": [ { "id": "GBG11_RAT", "url": "https://www.uniprot.org/uniprot/P61954", "type": "external" } ], "mass": 8481.0, "length": 73, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11", "gene_name": "Gng11", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11", "refseq_ac": [ { "id": "NP_071791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071791", "type": "external" } ], "gene_names_uniprotkb": "Gng11; Gngt11", "gene_names_refseq": "Gng11", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11", "protein_names_refseq": "guanine nucleotide binding protein (G protein), gamma 11; guanine nucleotide binding protein gamma subunit 11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11", "tax_id": 10116, "disease": "", "pathway": " (rno:64199); (R-RNO-1296041); (R-RNO-202040); (R-RNO-381676); (R-RNO-392170); (R-RNO-392451); (R-RNO-400042); (R-RNO-4086398); (R-RNO-416476); (R-RNO-418594); (R-RNO-418597); (R-RNO-420092); (R-RNO-428930); (R-RNO-432040); (R-RNO-456926); (R-RNO-8964616); (R-RNO-9856530); (R-RNO-997272)", "pathway_count": 18, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P50152;Q4V8M0", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding", "go_cellular_component": "GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P61954-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70490-1", "uniprot_id": [ { "id": "MFGM_RAT", "url": "https://www.uniprot.org/uniprot/P70490", "type": "external" } ], "mass": 47413.0, "length": 427, "protein_name": "Lactadherin", "gene_name": "Mfge8", "organism": "Rat", "refseq_name": "lactadherin isoform 1 precursor", "refseq_ac": [ { "id": "NP_001035276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035276", "type": "external" } ], "gene_names_uniprotkb": "Mfge8; Ags", "gene_names_refseq": "AGS; MFGME8; MFGMP-E8; Mfge8; OAcGD3S", "protein_names_uniprotkb": "Lactadherin; AGS; MFG-E8; MFGM; Milk fat globule-EGF factor 8; O-acetyl GD3 ganglioside synthase; SED1", "protein_names_refseq": "MFG-E8; MFGM; O-acetyl GD3 ganglioside synthase; O-acetyl disialoganglioside synthase; O-acetyltransferase Milk fat glolbule membrane protein; O-acetyltransferase milk fat globule membrane protein; SED1; lactadherin isoform 1 precursor; lactadherin; milk fat globule-EGF factor 8 protein", "tax_id": 10116, "disease": "temporal arteritis (Disease Ontology:DOID:13375)", "pathway": " (rno:25277); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "12670504;15240697;29393594;30154436;31615282;31958465;32945126;34169949;38843836;8780713", "class_list": "", "function": "Abolished the effect of rhMFG-E8 on anti-apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Contributes to phagocytic removal of apoptotic cells in many tissues. Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Appears to participate in the O-acetylation of GD3 ganglioside sialic acid., [UniProtKB]; MFGE8 attenuates Ang-II-induced atrial fibrosis and vulnerability to atrial fibrillation through inhibition of TGF-beta1/Smad2/3 pathway., [RefSeq, PubMed]; MFGE8 is down-regulated in cardiac fibrosis and attenuates endothelial-mesenchymal transition through Smad2/3-Snail signalling pathway., [RefSeq, PubMed]; Needle-shaped amyloid deposition in rat mammary gland: evidence of a novel amyloid fibril protein., [RefSeq, PubMed]; Study shows that OAcGD3S is strongly expressed during liver fibrogenesis and hepatic stellate cells seem to be the major cellular sources of OAcGD3S in the liver, [RefSeq, PubMed]; TMT-based quantitative proteomics analysis reveals the effect of bovine derived MFG-E8 against oxidative stress on rat L6 cells., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008429 phosphatidylethanolamine binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0006911 phagocytosis, engulfment;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P70490-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70492-1", "uniprot_id": [ { "id": "FGF10_RAT", "url": "https://www.uniprot.org/uniprot/P70492", "type": "external" } ], "mass": 24029.0, "length": 215, "protein_name": "Fibroblast growth factor 10", "gene_name": "Fgf10", "organism": "Rat", "refseq_name": "fibroblast growth factor 10 precursor", "refseq_ac": [ { "id": "NP_037083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037083", "type": "external" } ], "gene_names_uniprotkb": "Fgf10", "gene_names_refseq": "FGF-10; Fgf10; Fgf5a", "protein_names_uniprotkb": "Fibroblast growth factor 10; FGF-10", "protein_names_refseq": "fibroblast growth factor 10 precursor; fibroblast growth factor 5a", "tax_id": 10116, "disease": "lacrimoauriculodentodigital syndrome 1 (Disease Ontology:DOID:0050331); developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425); childhood-onset asthma (Disease Ontology:DOID:0080815); vitamin D-dependent rickets type 1A (Disease Ontology:DOID:0080886); lacrimoauriculodentodigital syndrome 3 (Disease Ontology:DOID:0081372); aplasia of lacrimal and salivary glands (Disease Ontology:DOID:0111549); intestinal atresia (Disease Ontology:DOID:10486); pre-eclampsia (Disease Ontology:DOID:10591); rickets (Disease Ontology:DOID:10609); hypospadias (Disease Ontology:DOID:10892); gestational diabetes (Disease Ontology:DOID:11714); alcohol use disorder (Disease Ontology:DOID:1574); hepatitis B (Disease Ontology:DOID:2043); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); Wilson disease (Disease Ontology:DOID:893); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25443); (R-RNO-109704); (R-RNO-1257604); (R-RNO-190370); (R-RNO-190377); (R-RNO-5654219); (R-RNO-5654221); (R-RNO-5654687); (R-RNO-5654688); (R-RNO-5654689); (R-RNO-5654693); (R-RNO-5654695); (R-RNO-5654699); (R-RNO-5654700); (R-RNO-5654726); (R-RNO-5654727); (R-RNO-5658623); (R-RNO-5673001); (R-RNO-6811558)", "pathway_count": 19, "publication_count": 4, "publication_id_list": "29758198;33577857;35934252;8663172", "class_list": "", "function": "FGF 10 Inhibited Spinal Microglial Activation in Neuropathic Pain via PPAR-gamma/NF-kappaB Signaling., [RefSeq, PubMed]; LncRNA TUG1/miR-145-5p/FGF10 promotes the proliferation and migration of Vascular smooth muscle cell in hypertensive state by activating the Wnt/beta-catenin pathway., [RefSeq, PubMed]; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing., [UniProtKB]; Testosterone exposure in prenatal life disrupts epithelial nuclear morphology, smooth muscle layer pattern, and FGF10 and Shh expression in prostate., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0008083 growth factor activity;GO:0005111 type 2 fibroblast growth factor receptor binding;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0030878 thyroid gland development;GO:0046579 positive regulation of Ras protein signal transduction;GO:0001759 organ induction;GO:0048752 semicircular canal morphogenesis;GO:0060594 mammary gland specification", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70492-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70596-1", "uniprot_id": [ { "id": "MC4R_RAT", "url": "https://www.uniprot.org/uniprot/P70596", "type": "external" } ], "mass": 36887.0, "length": 332, "protein_name": "Melanocortin receptor 4", "gene_name": "Mc4r", "organism": "Rat", "refseq_name": "melanocortin receptor 4", "refseq_ac": [ { "id": "NP_037231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037231", "type": "external" } ], "gene_names_uniprotkb": "Mc4r", "gene_names_refseq": "Mc4r", "protein_names_uniprotkb": "Melanocortin receptor 4; MC4-R", "protein_names_refseq": "MC4-R; melanocortin receptor 4", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); alcohol dependence (Disease Ontology:DOID:0050741); left ventricular noncompaction (Disease Ontology:DOID:0060480); myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis 2 (Disease Ontology:DOID:0061184); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); sciatic neuropathy (Disease Ontology:DOID:11446); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); morbid obesity (Disease Ontology:DOID:11981); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); morphine dependence (Disease Ontology:DOID:2560); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25635); (R-RNO-375276)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "32035118;32378055;35304172;38960135;8794897", "class_list": "", "function": "Activation of the Melanocortin-4 Receptor Prevents Oxidative Damage and Mitochondrial Dysfunction in Cultured Hippocampal Neurons Exposed to Ethanol., [RefSeq, PubMed]; G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha- and beta-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor. Functions as a central component of the leptin-melanocortin pathway, which is essential for maintaining energy homeostasis. Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway, which promotes anorexogenic signaling in the hypothalamus and contributes to a negative energy balance. Regulates food intake: activation by agonists suppresses appetite, whereas the antagonist Agouti-related protein/AGRP precludes agonist-induced signaling, thereby stimulating appetite. Modulates the firing activity of neurons in paraventricular nucleus (PVN) of the hypothalamus via alpha-MSH and AGRP regulation of inwardly rectifying potassium channel KCNJ13 closure, independently of G(s) signaling. In the PVN, also interacts with opsin 3/OPN3, which couples to G(i/o) proteins to inhibit MC4R-mediated cAMP signaling, thereby promoting food intake. In intestinal epithelial cells, contributes to inhibition of hepatic glucose production via nesfatin-1/NUCB2, leading to increased cAMP levels and glucagon-like peptide 1 (GLP-1) secretion. Interaction with MGRN1 displaces the G(s) protein, further decreasing MC4R signaling activity. Also activated by gamma-MSH, though with low potency., [UniProtKB, UniProtKB]; Melanocortin-4 receptor signaling in the central amygdala mediates chronic inflammatory pain effects on nociception., [RefSeq, PubMed]; Melanocortin-receptor 4 activation modulates proliferation and differentiation of rat postnatal hippocampal neural precursor cells., [RefSeq, PubMed]; Nicotine-induced Brain Stimulation Reward is Modulated by Melanocortin-4 Receptors in Ovariectomized Rats., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0042562 hormone binding;GO:0017046 peptide hormone binding;GO:0004977 melanocortin receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098804 non-motile cilium membrane", "go_biological_process": "GO:1903999 negative regulation of eating behavior;GO:2000252 negative regulation of feeding behavior;GO:1903998 regulation of eating behavior;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P70596-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97521-1", "uniprot_id": [ { "id": "MCAT_RAT", "url": "https://www.uniprot.org/uniprot/P97521", "type": "external" } ], "mass": 33154.0, "length": 301, "protein_name": "Mitochondrial carnitine/acylcarnitine carrier protein", "gene_name": "Slc25a20", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc25a20; Cact", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial carnitine/acylcarnitine carrier protein; CACT; CAC; Carnitine/acylcarnitine translocase; Solute carrier family 25 member 20", "protein_names_refseq": "", "tax_id": 10116, "disease": "carnitine-acylcarnitine translocase deficiency (Disease Ontology:DOID:0111585); lipid metabolism disorder (Disease Ontology:DOID:3146)", "pathway": " (R-RNO-200425)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "8305461;9032458;9731180", "class_list": "", "function": "Mediates the electroneutral exchange of acylcarnitines (O-acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)-carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism (PubMed:9731180). Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation (Probable). Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange) (PubMed:8305461)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005476 carnitine:O-acyl-L-carnitine antiporter activity;GO:0015227 O-acyl-L-carnitine transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006839 mitochondrial transport;GO:0006853 carnitine shuttle;GO:1902603 carnitine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97521-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97523-1", "uniprot_id": [ { "id": "MET_RAT", "url": "https://www.uniprot.org/uniprot/P97523", "type": "external" } ], "mass": 153941.0, "length": 1382, "protein_name": "Hepatocyte growth factor receptor", "gene_name": "Met", "organism": "Rat", "refseq_name": "hepatocyte growth factor receptor isoform 1 precursor", "refseq_ac": [ { "id": "NP_113705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113705", "type": "external" } ], "gene_names_uniprotkb": "Met", "gene_names_refseq": "Hgfr; Met", "protein_names_uniprotkb": "Hepatocyte growth factor receptor; 2.7.10.1; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; SF receptor; Scatter factor receptor; Tyrosine-protein kinase Met", "protein_names_refseq": "HGF receptor; HGF/SF receptor; SF receptor; c-Met; hepatocyte growth factor receptor isoform 1 precursor; hepatocyte growth factor receptor; met proto-oncogene tyrosine kinase; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met", "tax_id": 10116, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive nonsyndromic deafness 97 (Disease Ontology:DOID:0110539); prostate carcinoma (Disease Ontology:DOID:10286); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); sarcoma (Disease Ontology:DOID:1115); gestational diabetes (Disease Ontology:DOID:11714); autistic disorder (Disease Ontology:DOID:12849); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); invasive ductal carcinoma (Disease Ontology:DOID:3008); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); papillary renal cell carcinoma (Disease Ontology:DOID:4465); large cell carcinoma (Disease Ontology:DOID:4552); cholangiocarcinoma (Disease Ontology:DOID:4947); pancreatitis (Disease Ontology:DOID:4989); gastrinoma (Disease Ontology:DOID:5577); hepatocellular carcinoma (Disease Ontology:DOID:684); periodontitis (Disease Ontology:DOID:824); liver benign neoplasm (Disease Ontology:DOID:916); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (rno:24553); (R-RNO-1257604); (R-RNO-416550); (R-RNO-5673001); (R-RNO-6806942); (R-RNO-6807004); (R-RNO-6811558); (R-RNO-8851805); (R-RNO-8851907); (R-RNO-8865999); (R-RNO-8874081); (R-RNO-8875513); (R-RNO-8875555); (R-RNO-8875656); (R-RNO-8875791); (R-RNO-9734091)", "pathway_count": 16, "publication_count": 11, "publication_id_list": "21454685;25277788;25674220;26972715;28679425;29393594;38843836;7628535;8166728;8853431;9271668", "class_list": "", "function": "Mesenchymal stromal cells increased serum and tissue HGF levels, Met tubular expression and prevented the suppression of tubular MSP/RON expression. Publication Status: Online-Only, [RefSeq, PubMed]; Met was strongly expressed in BASCs, which expressed an AT2 cell marker, pro-SP-C, and a club cell marker, CCSP. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Also promotes differentiation and proliferation of hematopoietic cells (By similarity)., [UniProtKB]; The dynamic expression and localization of different c-MET isoforms in the rat pancreas during different developmental stages indicates that distinct c-MET isoform might be involved in different aspects of pancreatic development Publication Status: Online-Only, [RefSeq, PubMed]; Transplantation of c-Met-bone marrow-derived mesenchymal stem cells (BMSCs) ameliorated liver injury with reduced hepatic activity index (HAI) scores, and that the effects of c-Met-BMSCs were more profound than those of control BMSCs. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 10, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 29, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "P97579;Q63119;Q63964", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0071635 negative regulation of transforming growth factor beta production;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001889 liver development;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P97523-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97592-1", "uniprot_id": [ { "id": "MCPT4_RAT", "url": "https://www.uniprot.org/uniprot/P97592", "type": "external" } ], "mass": 27042.0, "length": 246, "protein_name": "Mast cell protease 4", "gene_name": "Mcpt4", "organism": "Rat", "refseq_name": "mast cell protease 4 precursor", "refseq_ac": [ { "id": "NP_062194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062194", "type": "external" } ], "gene_names_uniprotkb": "Mcpt4", "gene_names_refseq": "Mcpt4", "protein_names_uniprotkb": "Mast cell protease 4; 3.4.21.-; Mast cell protease IV; rMCP-4; rMCP-IV", "protein_names_refseq": "mast cell protease 4 precursor; mast cell protease IV; rMCP-4; rMCP-IV", "tax_id": 10116, "disease": "diabetic encephalopathy (Disease Ontology:DOID:0050850); prostate cancer (Disease Ontology:DOID:10283); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); Huntington's disease (Disease Ontology:DOID:12858); major depressive disorder (Disease Ontology:DOID:1470); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian carcinoma (Disease Ontology:DOID:4001); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); pancreatitis (Disease Ontology:DOID:4989); psoriasis (Disease Ontology:DOID:8893); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:54270)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11896050;8996238", "class_list": "", "function": "Investigation of substrate recognition profile, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008201 heparin binding;GO:0042277 peptide binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0030163 protein catabolic process;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P97592-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97832-1", "uniprot_id": [ { "id": "HAND1_RAT", "url": "https://www.uniprot.org/uniprot/P97832", "type": "external" } ], "mass": 23810.0, "length": 216, "protein_name": "Heart- and neural crest derivatives-expressed protein 1", "gene_name": "Hand1", "organism": "Rat", "refseq_name": "heart- and neural crest derivatives-expressed protein 1", "refseq_ac": [ { "id": "NP_067603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067603", "type": "external" } ], "gene_names_uniprotkb": "Hand1; Ehand", "gene_names_refseq": "Hand1; eHand", "protein_names_uniprotkb": "Heart- and neural crest derivatives-expressed protein 1; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; eHAND", "protein_names_refseq": "extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; heart and neural crest derivatives expressed transcript 1; heart- and neural crest derivatives-expressed protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:59112)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14636580;19170063", "class_list": "", "function": "Foxc2 is directly involved in the regulation of Hand1 expression., [RefSeq, PubMed]; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V8L8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P97832-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97852-1", "uniprot_id": [ { "id": "DHB4_RAT", "url": "https://www.uniprot.org/uniprot/P97852", "type": "external" } ], "mass": 79428.0, "length": 735, "protein_name": "Peroxisomal multifunctional enzyme type 2", "gene_name": "Hsd17b4", "organism": "Rat", "refseq_name": "peroxisomal multifunctional enzyme type 2", "refseq_ac": [ { "id": "NP_077368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077368", "type": "external" } ], "gene_names_uniprotkb": "Hsd17b4; Edh17b4", "gene_names_refseq": "Hsd17b4; MFP-2; MPF-2", "protein_names_uniprotkb": "Peroxisomal multifunctional enzyme type 2; 17-beta-HSD 4; 17-beta-hydroxysteroid dehydrogenase 4; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; D-bifunctional protein; DBP; MFE-2; MFP-2; Multifunctional protein 2", "protein_names_refseq": "17-beta-HSD 4; 17-beta-hydroxysteroid dehydrogenase 4; D-bifunctional protein; DBP; MFE-2; multifunctional protein 2; peroxisomal multifunctional enzyme type 2; peroxisomal multifunctional enzyme type II", "tax_id": 10116, "disease": "Perrault syndrome (Disease Ontology:DOID:0050857); D-bifunctional protein deficiency (Disease Ontology:DOID:0090031); hypertension (Disease Ontology:DOID:10763); Stiff-Person syndrome (Disease Ontology:DOID:13366); lipid metabolism disorder (Disease Ontology:DOID:3146); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:79244); (R-RNO-193368); (R-RNO-2046106); (R-RNO-389887); (R-RNO-390247); (R-RNO-9033241)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "12517343;29917219;38843836;8856068;8913347;9003397;9003427", "class_list": "", "function": "Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; HSD17B4 is over-expressed in rat liver cancer tissues. Its expression was positively correlated with TNF-alpha, IL-6 and PCNA levels., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70523;P70540", "ec_number_list": [ { "id": "4.2.1.134", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.134", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "4.2.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.107", "type": "external" }, { "id": "4.2.1.119", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.119", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0004300 enoyl-CoA hydratase activity;GO:0016853 isomerase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0000038 very long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P97852-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98089-1", "uniprot_id": [ { "id": "MUC2L_RAT", "url": "https://www.uniprot.org/uniprot/P98089", "type": "external" } ], "mass": 91500.0, "length": 837, "protein_name": "Intestinal mucin-like protein", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Intestinal mucin-like protein; MLP", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1371999", "class_list": "", "function": "", "predicted_glycosites": 18, "predicted_n_glycosites": 14, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:1903136 cuprous ion binding;GO:1903135 cupric ion binding;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0070701 mucus layer;GO:0031012 extracellular matrix;GO:0070702 inner mucus layer;GO:0070703 outer mucus layer", "go_biological_process": "GO:0071559 response to transforming growth factor beta;GO:0008285 negative regulation of cell population proliferation;GO:0032496 response to lipopolysaccharide;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P98089-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01460-1", "uniprot_id": [ { "id": "DIAC_RAT", "url": "https://www.uniprot.org/uniprot/Q01460", "type": "external" } ], "mass": 41531.0, "length": 367, "protein_name": "Di-N-acetylchitobiase", "gene_name": "Ctbs", "organism": "Rat", "refseq_name": "di-N-acetylchitobiase precursor", "refseq_ac": [ { "id": "NP_112285", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112285", "type": "external" } ], "gene_names_uniprotkb": "Ctbs; Ctb", "gene_names_refseq": "Ctbs", "protein_names_uniprotkb": "Di-N-acetylchitobiase; 3.2.1.-", "protein_names_refseq": "chitobiase, di-N-acetyl-; di-N-acetylchitobiase precursor; di-N-acetylchitobiase", "tax_id": 10116, "disease": "", "pathway": " (rno:81652)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1527079;2751306", "class_list": "glycogene;glycosylhydrolase", "function": "Reducing-end exoglycosidase involved in glycan degradation. Hydrolyzes N,N'-diacetylchitobiose (GlnNAc2) and higher chitin-oligosaccharides (GlcNAc(n)) to monomeric GlcNAc acting on reducing-end residues (PubMed:2751306). During N-linked glycoprotein degradation, it cleaves single GlcNAc molecules uniquely from the reducing end of N,N'-diacetylchitobiose units linking oligosaccharides to proteins, and therefore it functions after cleavage of the Asn-GlcNAc bond and asparagine removal by glycosylasparaginase (PubMed:2751306)., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0004568 chitinase activity;GO:0008061 chitin binding", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0016052 carbohydrate catabolic process;GO:0006032 chitin catabolic process;GO:0009313 oligosaccharide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q01460-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01579-1", "uniprot_id": [ { "id": "GSTT1_RAT", "url": "https://www.uniprot.org/uniprot/Q01579", "type": "external" } ], "mass": 27468.0, "length": 240, "protein_name": "Glutathione S-transferase theta-1", "gene_name": "Gstt1", "organism": "Rat", "refseq_name": "glutathione S-transferase theta-1", "refseq_ac": [ { "id": "NP_445745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445745", "type": "external" } ], "gene_names_uniprotkb": "Gstt1", "gene_names_refseq": "GST T1-1; GSTYRS; Gstt1", "protein_names_uniprotkb": "Glutathione S-transferase theta-1; 2.5.1.18; GST 5-5; GST class-theta-1; Glutathione S-transferase 5", "protein_names_refseq": "GSH transferase theta 1-1; GST 5-5; GST class-theta-1; Glutathione S-transferase 1 (theta); glutathione S-transferase 5; glutathione S-transferase theta-1", "tax_id": 10116, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); inflammatory bowel disease (Disease Ontology:DOID:0050589); alcohol dependence (Disease Ontology:DOID:0050741); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); medulloblastoma (Disease Ontology:DOID:0050902); myelodysplastic syndrome (Disease Ontology:DOID:0050908); pre-malignant neoplasm (Disease Ontology:DOID:0060071); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); drug allergy (Disease Ontology:DOID:0060500); alcohol-associated liver disease (Disease Ontology:DOID:0070658); mucositis (Disease Ontology:DOID:0080178); colorectal carcinoma (Disease Ontology:DOID:0080199); COVID-19 (Disease Ontology:DOID:0080600); venous insufficiency (Disease Ontology:DOID:10128); osteonecrosis (Disease Ontology:DOID:10159); prostate cancer (Disease Ontology:DOID:10283); lymphoid leukemia (Disease Ontology:DOID:1037); Hirschsprung's disease (Disease Ontology:DOID:10487); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); hypospadias (Disease Ontology:DOID:10892); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); head and neck cancer (Disease Ontology:DOID:11934); optic neuritis (Disease Ontology:DOID:1210); beta thalassemia (Disease Ontology:DOID:12241); neutropenia (Disease Ontology:DOID:1227); aplastic anemia (Disease Ontology:DOID:12449); cardiovascular system disease (Disease Ontology:DOID:1287); lung cancer (Disease Ontology:DOID:1324); Fanconi anemia (Disease Ontology:DOID:13636); exfoliation syndrome (Disease Ontology:DOID:13641); Parkinson's disease (Disease Ontology:DOID:14330); aggressive periodontitis (Disease Ontology:DOID:1474); cystic fibrosis (Disease Ontology:DOID:1485); acute chest syndrome (Disease Ontology:DOID:1584); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); congenital heart disease (Disease Ontology:DOID:1682); ovary epithelial cancer (Disease Ontology:DOID:2152); motor neuron disease (Disease Ontology:DOID:231); colon adenocarcinoma (Disease Ontology:DOID:234); anemia (Disease Ontology:DOID:2355); multiple sclerosis (Disease Ontology:DOID:2377); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); cervix carcinoma (Disease Ontology:DOID:2893); pulmonary tuberculosis (Disease Ontology:DOID:2957); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Lynch syndrome (Disease Ontology:DOID:3883); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); liver disease (Disease Ontology:DOID:409); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); esophagus adenocarcinoma (Disease Ontology:DOID:4914); esophageal cancer (Disease Ontology:DOID:5041); liver cirrhosis (Disease Ontology:DOID:5082); peripheral nervous system disease (Disease Ontology:DOID:574); oral submucous fibrosis (Disease Ontology:DOID:5773); leukopenia (Disease Ontology:DOID:615); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); cataract (Disease Ontology:DOID:83); lung disease (Disease Ontology:DOID:850); Hodgkin's lymphoma (Disease Ontology:DOID:8567); infectious mononucleosis (Disease Ontology:DOID:8568); ulcerative colitis (Disease Ontology:DOID:8577); oral cavity cancer (Disease Ontology:DOID:8618); myeloid leukemia (Disease Ontology:DOID:8692); Crohn's disease (Disease Ontology:DOID:8778); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease Ontology:DOID:9669); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25260); (R-RNO-156590); (R-RNO-9753281)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "1445253;1848757;20097269;33484035;8761485", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity., [UniProtKB, PubMed]; Inability of GSTT1 to activate iodinated halomethanes to mutagens in Salmonella., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 92, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0004602 glutathione peroxidase activity;GO:0047651 alkylhalidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0033197 response to vitamin E;GO:0010269 response to selenium ion;GO:0009410 response to xenobiotic stimulus;GO:0009751 response to salicylic acid;GO:0006304 DNA modification", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q01579-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02527-1", "uniprot_id": [ { "id": "MGAT3_RAT", "url": "https://www.uniprot.org/uniprot/Q02527", "type": "external" } ], "mass": 62022.0, "length": 538, "protein_name": "Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase", "gene_name": "Mgat3", "organism": "Rat", "refseq_name": "beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase", "refseq_ac": [ { "id": "NP_062112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062112", "type": "external" } ], "gene_names_uniprotkb": "Mgat3; Gnt3", "gene_names_refseq": "Mgat3", "protein_names_uniprotkb": "Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase; 2.4.1.144; GNT-III; GlcNAc-T III; N-acetylglucosaminyltransferase III; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III", "protein_names_refseq": "GNT-III; N-acetylglucosaminyltransferase III; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III; beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase; glcNAc-T III; mannoside acetyl glucosaminyltransferase 3; mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase", "tax_id": 10116, "disease": "autosomal dominant Robinow syndrome 2 (Disease Ontology:DOID:0060765); DiGeorge syndrome (Disease Ontology:DOID:11198); neurodegenerative disease (Disease Ontology:DOID:1289); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:29582); (R-RNO-975574)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1325461;20554946", "class_list": "glycogene;glycosyltransferase", "function": "GnT-III transfection has the potential to be an effective approach in humanizing the N-glycosylation of lepidopteran insect cells., [RefSeq, PubMed]; It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc). It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. The addition of this bisecting GlcNAc residue alters not only the composition, but also the conformation of the N-glycan. The introduction of the bisecting GlcNAc residue results in the suppression of further processing and elongation of N-glycans, precluding the formation of beta-1,6 GlcNAc branching, catalyzed by MGAT5 since it is unable to use the bisected oligosaccharide as a substrate. Addition of bisecting N-acetylglucosamine to CDH1/E-cadherin modulates CDH1 cell membrane location. Inhibits NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc- formation which modulates sialylation levels and plays a role in cell migration regulation (By similarity). In brain, addition of bisecting N-acetylglucosamine to BACE1 blocks its lysosomal targeting in response to oxidative stress and further degradation which increases its location to early endosome and the APP cleavage (By similarity). Adds bisecting GlcNAc residue to complex-type N-linked-glycans attached on fragment crystallizable (Fc) of IgGs. Readily converts fucosylated and non-fucosylated core glycoforms with terminal GlcNAcs on both antennae. Prior galactosylation of GlcNAc on the alpha(1->3) Man branch prevents N-glycan bisection, whereas galactosylation of GlcNAc on the alpha(1->6) Man branch is permissive., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.144", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.144", "type": "external" } ], "go_molecular_function": "GO:0003830 beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:1902966 positive regulation of protein localization to early endosome;GO:0050435 amyloid-beta metabolic process;GO:0050890 cognition;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 2382, "hit_score": 0.3, "record_id": "Q02527-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02644-1", "uniprot_id": [ { "id": "GHRHR_RAT", "url": "https://www.uniprot.org/uniprot/Q02644", "type": "external" } ], "mass": 51522.0, "length": 464, "protein_name": "Growth hormone-releasing hormone receptor", "gene_name": "Ghrhr", "organism": "Rat", "refseq_name": "growth hormone-releasing hormone receptor isoform 1 precursor", "refseq_ac": [ { "id": "NP_036982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036982", "type": "external" } ], "gene_names_uniprotkb": "Ghrhr; Grfr", "gene_names_refseq": "GHRHREC; Ghrhr", "protein_names_uniprotkb": "Growth hormone-releasing hormone receptor; GHRH receptor; GRF receptor; GRFR; Growth hormone-releasing factor receptor", "protein_names_refseq": "GHRH receptor; GRF receptor; GRFR; Growth hormone - releasing receptor; growth hormone-releasing factor receptor; growth hormone-releasing hormone receptor isoform 1 precursor", "tax_id": 10116, "disease": "isolated growth hormone deficiency (Disease Ontology:DOID:0060870); isolated growth hormone deficiency type IB (Disease Ontology:DOID:0060874); sleep disorder (Disease Ontology:DOID:535)", "pathway": " (rno:25321); (R-RNO-420092)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1333056;1334535;23417421;23770714;25404316", "class_list": "", "function": "Data show alterations in growth hormone (GH) synthesis and expression of GH-releasing hormone receptor (GHRH receptor) on cells of the immune system that may play a role in the immune response in aging., [RefSeq, PubMed]; Data show that cardiac stem cells (CSCs) isolated from mouse, rat and pig myocardium express growth hormone-releasing hormone receptor (GHRH-R) and agonists of GHRH-R stimulate their proliferation and survival., [RefSeq, PubMed]; GHRH protects the heart from I/R injury through GHRHR-mediated mechanisms, leading to activation of RISK and SAFE pathways, which converge on mitochondria and possibly on AMP-activated protein kinase., [RefSeq, PubMed]; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019838 growth factor binding;GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0016520 growth hormone-releasing hormone receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030141 secretory granule", "go_biological_process": "GO:0021984 adenohypophysis development;GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190 activation of adenylate cyclase activity;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q02644-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02769-1", "uniprot_id": [ { "id": "FDFT_RAT", "url": "https://www.uniprot.org/uniprot/Q02769", "type": "external" } ], "mass": 48106.0, "length": 416, "protein_name": "Squalene synthase", "gene_name": "Fdft1", "organism": "Rat", "refseq_name": "squalene synthase", "refseq_ac": [ { "id": "NP_062111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062111", "type": "external" } ], "gene_names_uniprotkb": "Fdft1", "gene_names_refseq": "Fdft1", "protein_names_uniprotkb": "Squalene synthase; 2.5.1.21; FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase; SQS; SS", "protein_names_refseq": "FPP:FPP farnesyltransferase; SQS; SS; farnesyl diphosphate farnesyltransferase; squalene synthase; squalene synthetase", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); cataract (Disease Ontology:DOID:83)", "pathway": " (rno:29580); (R-RNO-9969896)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1400448;1569107;16440058;17460354;29393594;32980992;8509416;9575210", "class_list": "", "function": "Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene (PubMed:9575210). Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway (By similarity)., [UniProtKB, PubMed, UniProtKB]; Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway., [UniProtKB, UniProtKB]; Protective mechanism of fdft1 in steroid hormone synthesis pathway in SD rats with acute hypoxic injury., [RefSeq, PubMed]; The hypomorphic Lss(S) and Fdft1(S) alleles are not specific to the SCR strain, but are widely prevalent in several other laboratory rat strains., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 22, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.21", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051996 squalene synthase [NAD(P)H] activity;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006695 cholesterol biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol;GO:0033490 cholesterol biosynthetic process via lathosterol;GO:0008299 isoprenoid biosynthetic process;GO:0045338 farnesyl diphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q02769-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02874-2", "uniprot_id": [ { "id": "H2AY_RAT", "url": "https://www.uniprot.org/uniprot/Q02874", "type": "external" } ], "mass": 39040.0, "length": 368, "protein_name": "Core histone macro-H2A.1", "gene_name": "Macroh2a1", "organism": "Rat", "refseq_name": "core histone macro-H2A.1", "refseq_ac": [ { "id": "NP_058878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058878", "type": "external" } ], "gene_names_uniprotkb": "Macroh2a1; H2afy", "gene_names_refseq": "H2A.y; H2A/y; H2afy; Macroh2a1; mH2A1", "protein_names_uniprotkb": "Core histone macro-H2A.1; H2A.y; H2A/y; Histone macroH2A1; mH2A1", "protein_names_refseq": "H2A histone family, member Y; core histone macro-H2A.1; histone macroH2A1", "tax_id": 10116, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908)", "pathway": " (rno:29384)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1529340;16107708;22673903;9138085", "class_list": "", "function": "In contrast to isoform 1, does not bind poly-ADP-ribose. Represses SOD3 gene expression., [UniProtKB, UniProtKB]; Isoform that specifically binds poly-ADP-ribose and O-acetyl-ADP-ribose and plays a key role in NAD(+) metabolism. Able to bind to the ends of poly-ADP-ribose chains created by PARP1 and cap them. This prevents PARP1 from further addition of ADP-ribose and thus limits the consumption of nuclear NAD(+), allowing the cell to maintain proper NAD(+) levels in both the nucleus and the mitochondria to promote proper mitochondrial respiration. Increases the expression of genes involved in redox metabolism, including SOD3., [UniProtKB, UniProtKB]; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (PubMed:16107708). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PubMed:16107708). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (PubMed:16107708). Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (By similarity). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O09140;Q63325", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000793 condensed chromosome;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0019216 regulation of lipid metabolic process;GO:1902884 positive regulation of response to oxidative stress;GO:0045815 transcription initiation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q02874-2", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06145-1", "uniprot_id": [ { "id": "GIP_RAT", "url": "https://www.uniprot.org/uniprot/Q06145", "type": "external" } ], "mass": 16401.0, "length": 144, "protein_name": "Gastric inhibitory polypeptide", "gene_name": "Gip", "organism": "Rat", "refseq_name": "gastric inhibitory polypeptide precursor", "refseq_ac": [ { "id": "NP_062604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062604", "type": "external" } ], "gene_names_uniprotkb": "Gip", "gene_names_refseq": "Gip; Gludins; RATGLUDINS", "protein_names_uniprotkb": "Gastric inhibitory polypeptide; GIP; Glucose-dependent insulinotropic polypeptide", "protein_names_refseq": "Glucose-dependent insulinotropic peptide; gastric inhibitory polypeptide precursor; glucose-dependent insulinotropic polypeptide", "tax_id": 10116, "disease": "oculocutaneous albinism (Disease Ontology:DOID:0050632); autonomic nervous system disease (Disease Ontology:DOID:11465); polycystic ovary syndrome (Disease Ontology:DOID:11612); hypothyroidism (Disease Ontology:DOID:1459); hyperinsulinism (Disease Ontology:DOID:2018); pancreas disease (Disease Ontology:DOID:26); hyperglycemia (Disease Ontology:DOID:4195); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25040); (R-RNO-400511); (R-RNO-420092)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "1380834;1476614;25032669;26041107;26811539;33197511;33321289;8446620;8503905", "class_list": "", "function": "GIP-GIPR promotes neurite outgrowth of cortical neurons in Akt dependent manner., [RefSeq, PubMed]; GK-rats respond to gastric bypass surgery with improved glycemia despite unaffected insulin secretion and beta cell mass., [RefSeq, PubMed]; Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion., [UniProtKB, UniProtKB, UniProtKB]; Provide evidence that gastric inhibitory polypeptide regulates skeletal muscle glucose transport; however, the exact signaling mechanism(s) remain unknown, [RefSeq, PubMed]; Sitagliptin attenuated resistin expression via the GIP-dependent pathway, which inhibited sympathetic innervation through a signalling pathway involving phosphatidylinositol 3-kinase (PI3K) and Akt protein. Publication Status: Online-Only, [RefSeq, PubMed]; The role of GIP as a critical link between catch-up growth and the development of metabolic disturbances., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031769 glucagon receptor binding;GO:0005102 signaling receptor binding;GO:0005179 hormone activity;GO:0048018 receptor ligand activity;GO:0031767 gastric inhibitory polypeptide receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0043025 neuronal cell body;GO:0005576 extracellular region", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007613 memory;GO:0008344 adult locomotory behavior;GO:0032024 positive regulation of insulin secretion;GO:0042594 response to starvation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q06145-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06175-1", "uniprot_id": [ { "id": "HBEGF_RAT", "url": "https://www.uniprot.org/uniprot/Q06175", "type": "external" } ], "mass": 22843.0, "length": 208, "protein_name": "Proheparin-binding EGF-like growth factor", "gene_name": "Hbegf", "organism": "Rat", "refseq_name": "proheparin-binding EGF-like growth factor precursor", "refseq_ac": [ { "id": "NP_037077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037077", "type": "external" } ], "gene_names_uniprotkb": "Hbegf; Dtr; Hegfl", "gene_names_refseq": "Dtr; GFHB; Hb-egf; Hbegf; Hegfl", "protein_names_uniprotkb": "Proheparin-binding EGF-like growth factor", "protein_names_refseq": "Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor); heparin binding epidermal growth factor-like growth factor; heparin-binding epidermal -growth - like growth factor; heparin-binding epidermal -growth factor; proheparin-binding EGF-like growth factor precursor; proheparin-binding EGF-like growth factor", "tax_id": 10116, "disease": "glomerulosclerosis (Disease Ontology:DOID:0050851); acute kidney failure (Disease Ontology:DOID:3021); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677)", "pathway": " (rno:25433); (R-RNO-1227986); (R-RNO-1236394); (R-RNO-1250196); (R-RNO-1250342); (R-RNO-1250347); (R-RNO-1257604); (R-RNO-177929); (R-RNO-179812); (R-RNO-180292); (R-RNO-180336); (R-RNO-182971); (R-RNO-1963640); (R-RNO-1963642); (R-RNO-212718); (R-RNO-2179392); (R-RNO-5673001); (R-RNO-6785631); (R-RNO-6811558); (R-RNO-8847993); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8857538); (R-RNO-8863795); (R-RNO-9009391)", "pathway_count": 25, "publication_count": 6, "publication_id_list": "31882563;35281434;36655849;37868978;38262115;7678488", "class_list": "", "function": "Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity)., [UniProtKB]; HB-EGF Plays a Pivotal Role in Mucosal Hyperplasia During Otitis Media Induced by a Viral Analog. Publication Status: Online-Only, [RefSeq, PubMed]; Hypothyroidism induces motor deficit via altered cerebellar HB-EGF/EGFR and autophagy. Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown of HB-EGF in rat islets blocks beta-cell proliferation in response to glucose ex vivo and in vivo in transplanted glucose-infused rats. Findings identify a novel glucose/HB-EGF/EGFR axis implicated in beta-cell compensation to increased metabolic demand., [RefSeq, PubMed]; Macrophage regulation of the 'second brain': CD163 intestinal macrophages interact with inhibitory interneurons to regulate colonic motility - evidence from the Cx3cr1-Dtr rat model. Publication Status: Online-Only, [RefSeq, PubMed]; MicroRNA-194-5p/Heparin-binding EGF-like growth factor signaling mediates dexamethasone-induced activation of pseudorabies virus in rat pheochromocytoma cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007399 nervous system development;GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration;GO:0030307 positive regulation of cell growth;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q06175-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06605-1", "uniprot_id": [ { "id": "GRZ1_RAT", "url": "https://www.uniprot.org/uniprot/Q06605", "type": "external" } ], "mass": 27236.0, "length": 248, "protein_name": "Granzyme-like protein 1", "gene_name": "", "organism": "Rat", "refseq_name": "granzyme-like protein 1-like precursor", "refseq_ac": [ { "id": "NP_001316820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001316820", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "LOC102553861", "protein_names_uniprotkb": "Granzyme-like protein 1; 3.4.21.-; GLP I; GLP-1; Granzyme-like protein I", "protein_names_refseq": "granzyme-like protein 1-like precursor; granzyme-like protein I", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8508925", "class_list": "", "function": "Serine protease necessary for target cell lysis in cell-mediated immune responses., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0044194 cytolytic granule", "go_biological_process": "GO:0051402 neuron apoptotic process;GO:0017148 negative regulation of translation;GO:0042742 defense response to bacterium;GO:0070269 pyroptotic inflammatory response;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q06605-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06606-1", "uniprot_id": [ { "id": "GRZ2_RAT", "url": "https://www.uniprot.org/uniprot/Q06606", "type": "external" } ], "mass": 27486.0, "length": 248, "protein_name": "Granzyme-like protein 2", "gene_name": "Mcpt10", "organism": "Rat", "refseq_name": "granzyme-like protein 2 precursor", "refseq_ac": [ { "id": "NP_058842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058842", "type": "external" } ], "gene_names_uniprotkb": "Mcpt10", "gene_names_refseq": "GLP II; GLP-2; Mcpt10; rMCP-10; rMCP-X", "protein_names_uniprotkb": "Granzyme-like protein 2; 3.4.21.-; GLP II; GLP-2; Granzyme-like protein II; Mast cell protease 10; Mast cell protease X; rMCP-10; rMCP-X", "protein_names_refseq": "granzyme-like protein 2 precursor; granzyme-like protein 2; granzyme-like protein II; mast cell protease X", "tax_id": 10116, "disease": "", "pathway": " (rno:29269); (rno:54269)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8508925", "class_list": "", "function": "Serine protease necessary for target cell lysis in cell-mediated immune responses., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q06606-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07523-1", "uniprot_id": [ { "id": "HAOX2_RAT", "url": "https://www.uniprot.org/uniprot/Q07523", "type": "external" } ], "mass": 39201.0, "length": 353, "protein_name": "2-Hydroxyacid oxidase 2", "gene_name": "Hao2", "organism": "Rat", "refseq_name": "2-Hydroxyacid oxidase 2", "refseq_ac": [ { "id": "NP_114471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114471", "type": "external" } ], "gene_names_uniprotkb": "Hao2; Hao3; Haox2", "gene_names_refseq": "Hao2; Hao3; LCHAO", "protein_names_uniprotkb": "2-Hydroxyacid oxidase 2; (S)-2-hydroxy-acid oxidase, peroxisomal; 1.1.3.15; HAOX2; LCHAO; Long chain alpha-hydroxy acid oxidase; Long-chain L-2-hydroxy acid oxidase", "protein_names_refseq": "(S)-2-hydroxy-acid oxidase, peroxisomal; 2-Hydroxyacid oxidase 2; HAOX2; hydroxyacid oxidase 2 (long chain); hydroxyacid oxidase 3 (medium-chain); long chain alpha-hydroxy acid oxidase; long-chain L-2-hydroxy acid oxidase", "tax_id": 10116, "disease": "", "pathway": " (rno:84029); (R-RNO-390918); (R-RNO-9033241)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15683236;1939137;22342614;22673903;26658681;3061453;8508789", "class_list": "", "function": "Dysregulation of HAO2 is a very early event in the development of hepatocellular carcinoma (HCC)., [RefSeq, PubMed]; Oxidase that catalyzes the oxidation of medium and long chain hydroxyacids such as 2-hydroxyhexadecanoate, 2-hydroxyoctanoate, 2-hydroxyhexanoate and 2-hydroxybutanoate, to the corresponding 2-oxoacids (PubMed:15683236, PubMed:3061453, PubMed:8508789). Its role in the oxidation of 2-hydroxy fatty acids may contribute to the general pathway of fatty acid alpha-oxidation (By similarity). Can also use mandelate as substrate (PubMed:3061453). Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2 (PubMed:15683236, PubMed:3061453, PubMed:8508789)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0010181 FMN binding;GO:0003973 (S)-2-hydroxy-acid oxidase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0018924 mandelate metabolic process;GO:0019395 fatty acid oxidation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q07523-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07731-1", "uniprot_id": [ { "id": "GDNF_RAT", "url": "https://www.uniprot.org/uniprot/Q07731", "type": "external" } ], "mass": 23619.0, "length": 211, "protein_name": "Glial cell line-derived neurotrophic factor", "gene_name": "Gdnf", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gdnf", "gene_names_refseq": "", "protein_names_uniprotkb": "Glial cell line-derived neurotrophic factor; ATF; Astrocyte-derived trophic factor", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:25453); (R-RNO-5673001); (R-RNO-8853659)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10828539;11930164;21994944;7696586;7867768;7895811;8493557;9187648", "class_list": "", "function": "Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed:10828539). Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor (By similarity). May also modulate local neuronal effects in distal regions of the motor neuron (PubMed:10828539). Involved in the development of the neural crest (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q63214;Q64062;Q64063;Q8R485;Q9QX94;Q9QX95;Q9QXJ7;Q9QXJ8;Q9QXJ9", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0030971 receptor tyrosine kinase binding;GO:0008083 growth factor activity;GO:0048018 receptor ligand activity;GO:0030116 glial cell-derived neurotrophic factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0043235 receptor complex", "go_biological_process": "GO:0001759 organ induction;GO:0030432 peristalsis;GO:0051584 regulation of dopamine uptake involved in synaptic transmission;GO:0048484 enteric nervous system development;GO:0021516 dorsal spinal cord development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q07731-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08326-1", "uniprot_id": [ { "id": "MSS4_RAT", "url": "https://www.uniprot.org/uniprot/Q08326", "type": "external" } ], "mass": 13928.0, "length": 123, "protein_name": "Guanine nucleotide exchange factor MSS4", "gene_name": "Rabif", "organism": "Rat", "refseq_name": "guanine nucleotide exchange factor MSS4", "refseq_ac": [ { "id": "NP_001007679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007679", "type": "external" } ], "gene_names_uniprotkb": "Rabif; Mss4", "gene_names_refseq": "Mss4; RGD1563962; Rabif", "protein_names_uniprotkb": "Guanine nucleotide exchange factor MSS4; Rab-interacting factor", "protein_names_refseq": "guanine nucleotide exchange factor MSS4; guanine-nucleotide-releasing protein mss4; mammalian suppressor of Sec4", "tax_id": 10116, "disease": "", "pathway": " (rno:304807)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11258916;12105226;21427360;25303613;8429887", "class_list": "", "function": "Female-biased transcript levels when controlled by BDIV resistance alleles at Mss4., [RefSeq, PubMed]; Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1, RAB3A and RAB10, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport., [UniProtKB, UniProtKB]; MSS4 modulates Rab15 activity in early endocytosis (also called RABIF)., [RefSeq, PubMed]; Transcription profiling using trigeminal nerve tissue of BDIX, BDIV, and BDIX.BDIV-Mss4a congenics of both sexes revealed 61 genes located in the Mss4a fragment differentially expressed between BDIV and BDIX rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0015031 protein transport;GO:0007264 small GTPase-mediated signal transduction;GO:0006892 post-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q08326-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08834-1", "uniprot_id": [ { "id": "MGT5A_RAT", "url": "https://www.uniprot.org/uniprot/Q08834", "type": "external" } ], "mass": 84562.0, "length": 740, "protein_name": "Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A", "gene_name": "Mgat5", "organism": "Rat", "refseq_name": "alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A", "refseq_ac": [ { "id": "NP_075583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075583", "type": "external" } ], "gene_names_uniprotkb": "Mgat5", "gene_names_refseq": "Mgat5", "protein_names_uniprotkb": "Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A; 2.4.1.155; Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase; GNT-V; GlcNAc-T V; Mannoside acetylglucosaminyltransferase 5; N-acetylglucosaminyl-transferase V; Secreted GNT-V; Secreted beta-1,6-N-acetylglucosaminyltransferase V", "protein_names_refseq": "GNT-V; N-acetylglucosaminyl-transferase V; N-acetylglucosaminyltransferase V; alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase; alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A-like; alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A; alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase; glcNAc-T V; mannoside acetylglucosaminyltransferase 5; mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase", "tax_id": 10116, "disease": "proteinuria (Disease Ontology:DOID:576)", "pathway": " (rno:65271); (R-RNO-975577)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16641100;38499842;7615638;8340368", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides (PubMed:7615638, PubMed:8340368). Catalyzes an important step in the biosynthesis of branched, complex-type N-glycans, such as those found on EGFR, TGFR (TGF-beta receptor) and CDH2 (By similarity). Via its role in the biosynthesis of complex N-glycans, plays an important role in the activation of cellular signaling pathways, reorganization of the actin cytoskeleton, cell-cell adhesion and cell migration (PubMed:7615638). MGAT5-dependent EGFR N-glycosylation enhances the interaction between EGFR and LGALS3 and thereby prevents rapid EGFR endocytosis and prolongs EGFR signaling. Required for efficient interaction between TGFB1 and its receptor. Enhances activation of intracellular signaling pathways by several types of growth factors, including FGF2, PDGF, IGF, TGFB1 and EGF. MGAT5-dependent CDH2 N-glycosylation inhibits CDH2-mediated homotypic cell-cell adhesion and contributes to the regulation of downstream signaling pathways. Promotes cell migration. Contributes to the regulation of the inflammatory response. MGAT5-dependent TCR N-glycosylation enhances the interaction between TCR and LGALS3, limits agonist-induced TCR clustering, and thereby dampens TCR-mediated responses to antigens. Required for normal leukocyte evasation and accumulation at sites of inflammation (By similarity). Inhibits attachment of monocytes to the vascular endothelium and subsequent monocyte diapedesis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; GnT-V-mediated aberrant N-glycosylation of TIMP-1 promotes diabetic retinopathy progression. Publication Status: Online-Only, [RefSeq, PubMed]; Promotes proliferation of umbilical vein endothelial cells and angiogenesis, at least in part by promoting the release of the growth factor FGF2 from the extracellular matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.155", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0016757 glycosyltransferase activity;GO:0004864 protein phosphatase inhibitor activity;GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0006487 protein N-linked glycosylation;GO:1904894 positive regulation of receptor signaling pathway via STAT", "synthesized_glycan_count": 2831, "hit_score": 0.5, "record_id": "Q08834-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09325-1", "uniprot_id": [ { "id": "MGAT1_RAT", "url": "https://www.uniprot.org/uniprot/Q09325", "type": "external" } ], "mass": 51586.0, "length": 447, "protein_name": "Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase", "gene_name": "Mgat1", "organism": "Rat", "refseq_name": "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase", "refseq_ac": [ { "id": "NP_110488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110488", "type": "external" } ], "gene_names_uniprotkb": "Mgat1; Gnt1", "gene_names_refseq": "Mgat1", "protein_names_uniprotkb": "Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; 2.4.1.101; GNT-I; GlcNAc-T I; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I", "protein_names_refseq": "GNT-I; MGAT1 gene for N-acetylglucosaminyltransferase; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I; alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; glcNAc-T I; mannoside acetylglucosaminyltransferase 1; mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:81519); (R-RNO-964739)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12913295;7764514", "class_list": "glycogene;glycosyltransferase", "function": "Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans., [UniProtKB, UniProtKB]; The unusually long 5'-UTR of the major GnT-I transcript in rat brain was shown to inhibit protein production from the following coding sequence in COS7 cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.101", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.101", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006487 protein N-linked glycosylation;GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway", "synthesized_glycan_count": 9485, "hit_score": 0.3, "record_id": "Q09325-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09326-1", "uniprot_id": [ { "id": "MGAT2_RAT", "url": "https://www.uniprot.org/uniprot/Q09326", "type": "external" } ], "mass": 51110.0, "length": 442, "protein_name": "Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase", "gene_name": "Mgat2", "organism": "Rat", "refseq_name": "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase precursor", "refseq_ac": [ { "id": "NP_446056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446056", "type": "external" } ], "gene_names_uniprotkb": "Mgat2; Gnt2", "gene_names_refseq": "Gnt2; Mgat2", "protein_names_uniprotkb": "Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; 2.4.1.143; Beta-1,2-N-acetylglucosaminyltransferase II; GNT-II; GlcNAc-T II; Mannoside acetylglucosaminyltransferase 2; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II", "protein_names_refseq": "GNT-II; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II; alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase precursor; beta-1,2-N-acetylglucosaminyltransferase II; beta-12-N-acetylglucosaminyltransferase II; glcNAc-T II; mannoside acetylglucosaminyltransferase 2; mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase", "tax_id": 10116, "disease": "congenital disorder of glycosylation type IIa (Disease Ontology:DOID:0070253)", "pathway": " (rno:94273); (R-RNO-975578)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "25164810;29393594;7797505", "class_list": "glycogene;glycosyltransferase", "function": "Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans., [UniProtKB, PubMed]; The interaction of DGAT2 and MGAT2 serves to channel lipid substrates efficiently for triacylglycerol biosynthesis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.143", "type": "external" } ], "go_molecular_function": "GO:0008455 alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity;GO:0030145 manganese ion binding;GO:0042803 protein homodimerization activity;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005795 Golgi stack;GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane;GO:0015934 large ribosomal subunit", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0009312 oligosaccharide biosynthetic process", "synthesized_glycan_count": 8635, "hit_score": 0.4, "record_id": "Q09326-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VGK0-1", "uniprot_id": [ { "id": "GBRL1_RAT", "url": "https://www.uniprot.org/uniprot/Q0VGK0", "type": "external" } ], "mass": 14044.0, "length": 117, "protein_name": "Gamma-aminobutyric acid receptor-associated protein-like 1", "gene_name": "Gabarapl1", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid receptor-associated protein-like 1", "refseq_ac": [ { "id": "NP_001037759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037759", "type": "external" } ], "gene_names_uniprotkb": "Gabarapl1; Gec1", "gene_names_refseq": "Gabarapl1; Gec1", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor-associated protein-like 1; GABA(A) receptor-associated protein-like 1; GEC-1; Glandular epithelial cell protein 1", "protein_names_refseq": "GABA(A) receptor-associated protein like 1; GEC-1; gamma-aminobutyric acid (GABA(A)) receptor-associated protein-like 1; gamma-aminobutyric acid receptor-associated protein-like 1; glandular epithelial cell protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:689161); (R-RNO-1632852)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16650615;18423580;19524128", "class_list": "", "function": "Gec1 expression is dependent upon the circadian clock machinery in GnRH-expressing neurons., [RefSeq, PubMed]; The putative role in the trafficking of receptor GABA(A), [RefSeq, PubMed]; Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0031625 ubiquitin protein ligase binding;GO:0030957 Tat protein binding;GO:0008429 phosphatidylethanolamine binding;GO:0050811 GABA receptor binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005874 microtubule", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0000423 mitophagy;GO:0006995 cellular response to nitrogen starvation;GO:0061723 glycophagy", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q0VGK0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27W02-1", "uniprot_id": [ { "id": "MGN_RAT", "url": "https://www.uniprot.org/uniprot/Q27W02", "type": "external" } ], "mass": 17164.0, "length": 146, "protein_name": "Protein mago nashi homolog", "gene_name": "Magoh", "organism": "Rat", "refseq_name": "protein mago nashi homolog", "refseq_ac": [ { "id": "NP_001094006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094006", "type": "external" } ], "gene_names_uniprotkb": "Magoh", "gene_names_refseq": "Magoh", "protein_names_uniprotkb": "Protein mago nashi homolog; Mago-nashi-like proliferation-associated protein", "protein_names_refseq": "mago homolog, exon junction complex core component; mago-nashi homolog, proliferation-associated; mago-nashi-like proliferation-associated protein; protein mago nashi homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:298385); (R-RNO-159236); (R-RNO-72163); (R-RNO-975957)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "16275927", "class_list": "", "function": "Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S pre-initiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0006406 mRNA export from nucleus;GO:0006417 regulation of translation;GO:0008380 RNA splicing;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q27W02-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29TV8-1", "uniprot_id": [ { "id": "GKN2_RAT", "url": "https://www.uniprot.org/uniprot/Q29TV8", "type": "external" } ], "mass": 20369.0, "length": 184, "protein_name": "Gastrokine-2", "gene_name": "Gkn2", "organism": "Rat", "refseq_name": "gastrokine-2 precursor", "refseq_ac": [ { "id": "NP_001034775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034775", "type": "external" } ], "gene_names_uniprotkb": "Gkn2; Blot", "gene_names_refseq": "Gkn2; RGD1311934", "protein_names_uniprotkb": "Gastrokine-2; Blottin", "protein_names_refseq": "blottin; gastrokine-2 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:297419)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16888721", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0045178 basal part of cell", "go_biological_process": "GO:0002283 neutrophil activation involved in immune response;GO:0044546 NLRP3 inflammasome complex assembly;GO:0006954 inflammatory response;GO:0042127 regulation of cell population proliferation;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q29TV8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2AC31-1", "uniprot_id": [ { "id": "FFAR4_RAT", "url": "https://www.uniprot.org/uniprot/Q2AC31", "type": "external" } ], "mass": 40902.0, "length": 361, "protein_name": "Free fatty acid receptor 4", "gene_name": "Ffar4", "organism": "Rat", "refseq_name": "free fatty acid receptor 4", "refseq_ac": [ { "id": "NP_001040553", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040553", "type": "external" } ], "gene_names_uniprotkb": "Ffar4; Gpr120; O3far1", "gene_names_refseq": "Ffar4; Gpr120; O3far1", "protein_names_uniprotkb": "Free fatty acid receptor 4; G protein-coupled receptor 120; Omega-3 fatty acid receptor 1", "protein_names_refseq": "G-protein coupled receptor 120; free fatty acid receptor 4; omega-3 fatty acid receptor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:294075); (R-RNO-381771); (R-RNO-416476)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "18320172;28583918;29369009;30482157", "class_list": "", "function": "G protein-coupled receptor for long-chain fatty acids (LCFAs) with a major role in adipogenesis, energy metabolism and inflammation. Signals via G protein and beta-arrestin pathways. LCFAs sensing initiates activation of phosphoinositidase C-linked G proteins GNAQ and GNA11 (G(q)/G(11)), inducing a variety of cellular responses via second messenger pathways such as intracellular calcium mobilization, modulation of cyclic adenosine monophosphate (cAMP) production, and mitogen-activated protein kinases (MAPKs). After LCFAs binding, associates with beta-arrestin ARRB2 that acts as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (By similarity). In response to dietary fats, plays an important role in the regulation of adipocyte proliferation and differentiation. Acts as a receptor for omega-3 polyunsaturated fatty acids (PUFAs) at primary cilium of perivascular preadipocytes, initiating an adipogenic program via cAMP and CTCF-dependent chromatin remodeling that ultimately results in transcriptional activation of adipogenic genes and cell cycle entry. Induces differentiation of brown and beige adipocytes probably via autocrine and endocrine functions of FGF21 hormone. Contributes to the thermogenic activation of brown adipose tissue and the browning of white adipose tissue. Activates brown adipocytes by initiating intracellular calcium signaling leading to mitochondrial depolarization and fission, and overall increased mitochondrial respiration. Consequently stimulates fatty acid uptake and oxidation in mitochondria together with UCP1-mediated thermogenic respiration, eventually reducing fat mass. Regulates bi-potential differentiation of bone marrow mesenchymal stem cells toward osteoblasts or adipocytes likely by up-regulating distinct integrins. In response to dietary fats regulates hormone secretion and appetite. Stimulates GIP and GLP1 secretion from enteroendocrine cells as well as GCG secretion in pancreatic alpha cells, thereby playing a role in the regulation of blood glucose levels. Negatively regulates glucose-induced SST secretion in pancreatic delta cells. Mediates LCFAs inhibition of GHRL secretion, an appetite-controlling hormone. In taste buds, contributes to sensing of dietary fatty acids by the gustatory system. During the inflammatory response, promotes anti-inflammatory M2 macrophage differentiation in adipose tissue (By similarity). Mediates the anti-inflammatory effects of omega-3 PUFAs via inhibition of NLRP3 inflammasome activation (By similarity). In this pathway, interacts with adapter protein ARRB2 and inhibits the priming step triggered by Toll-like receptors (TLRs) at the level of TAK1 and TAB1 (By similarity). Further inhibits the activation step when ARRB2 directly associates with NLRP3, leading to inhibition of pro-inflammatory cytokine release (By similarity). Mediates LCFAs anti-apoptotic effects (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy, [RefSeq, PubMed]; Rat GPR120 is a G-protein-coupled receptor whose ligand is a free fatty acid, and it may play an important role in the FFA-associated physiological responses., [RefSeq, PubMed]; These findings suggest that GPR120, the sensing receptor for extracorporeal shockwave treatment, may be useful in the treatment of interstitial cystitis by inhibiting inflammatory response in bladder cells. Publication Status: Online-Only, [RefSeq, PubMed]; These present data have shown for the first time that total mRNA isolation and protein expression from both adipose tissues (abdominal and subcutaneous) of rat in obesity condition yield significative statistical difference among the control versus obese groups, showing that the diet high in carbohydrates modifies the total presence of mRNA and protein level expression of the receptors GPR41, 43 and 120, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005504 fatty acid binding;GO:1990763 arrestin family protein binding;GO:0008527 taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q2AC31-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32KJ6-1", "uniprot_id": [ { "id": "GALNS_RAT", "url": "https://www.uniprot.org/uniprot/Q32KJ6", "type": "external" } ], "mass": 58302.0, "length": 524, "protein_name": "N-acetylgalactosamine-6-sulfatase", "gene_name": "Galns", "organism": "Rat", "refseq_name": "N-acetylgalactosamine-6-sulfatase precursor", "refseq_ac": [ { "id": "NP_001041316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041316", "type": "external" } ], "gene_names_uniprotkb": "Galns", "gene_names_refseq": "Galns", "protein_names_uniprotkb": "N-acetylgalactosamine-6-sulfatase; 3.1.6.4; Chondroitinase; Chondroitinsulfatase; GalNAc6S sulfatase; Galactose-6-sulfate sulfatase; N-acetylgalactosamine-6-sulfate sulfatase", "protein_names_refseq": "N-acetylgalactosamine-6-sulfatase precursor; N-acetylgalactosamine-6-sulfatase; N-acetylgalactosamine-6-sulfate sulfatase; chondroitinase; chondroitinsulfatase; galNAc6S sulfatase; galactosamine (N-acetyl)-6-sulfate sulfatase; galactose-6-sulfate sulfatase", "tax_id": 10116, "disease": "mucopolysaccharidosis IVA (Disease Ontology:DOID:0111391); mucopolysaccharidosis IV (Disease Ontology:DOID:12804)", "pathway": " (rno:292073); (R-RNO-2022857); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "16174644;34504088", "class_list": "", "function": "Lysosomal enzyme that hydrolyzes sulfate groups from glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate (C6S)., [UniProtKB, UniProtKB]; Treatment of skeletal and non-skeletal alterations of Mucopolysaccharidosis type IVA by AAV-mediated gene therapy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" } ], "go_molecular_function": "GO:0043890 N-acetylgalactosamine-6-sulfatase activity;GO:0046872 metal ion binding;GO:0004065 arylsulfatase activity;GO:0008484 sulfuric ester hydrolase activity", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0030207 chondroitin sulfate proteoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q32KJ6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32PY6-1", "uniprot_id": [ { "id": "HENMT_RAT", "url": "https://www.uniprot.org/uniprot/Q32PY6", "type": "external" } ], "mass": 45087.0, "length": 394, "protein_name": "Small RNA 2'-O-methyltransferase", "gene_name": "Henmt1", "organism": "Rat", "refseq_name": "small RNA 2'-O-methyltransferase", "refseq_ac": [ { "id": "NP_001032744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032744", "type": "external" } ], "gene_names_uniprotkb": "Henmt1; AABR07012856.1", "gene_names_refseq": "Henmt1; RGD1306230", "protein_names_uniprotkb": "Small RNA 2'-O-methyltransferase; 2.1.1.386; HEN1 methyltransferase homolog 1", "protein_names_refseq": "HEN1 methyltransferase homolog 1; small RNA 2'-O-methyltransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:100363095)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.386", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.386", "type": "external" } ], "go_molecular_function": "GO:0090486 small RNA 2'-O-methyltransferase activity;GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0008171 O-methyltransferase activity;GO:0008173 RNA methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0043186 P granule", "go_biological_process": "GO:0030422 siRNA processing;GO:0034587 piRNA processing;GO:0001510 RNA methylation;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32PY6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32PY9-1", "uniprot_id": [ { "id": "GNTK_RAT", "url": "https://www.uniprot.org/uniprot/Q32PY9", "type": "external" } ], "mass": 20210.0, "length": 185, "protein_name": "Gluconokinase", "gene_name": "Idnk", "organism": "Rat", "refseq_name": "probable gluconokinase", "refseq_ac": [ { "id": "NP_001032439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032439", "type": "external" } ], "gene_names_uniprotkb": "Idnk", "gene_names_refseq": "Idnk", "protein_names_uniprotkb": "Gluconokinase; 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Erratum:[Mol Med. 2011 Sep-Oct;17(9-10):1129], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q32ZI4-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B8Q0-1", "uniprot_id": [ { "id": "MARE2_RAT", "url": "https://www.uniprot.org/uniprot/Q3B8Q0", "type": "external" } ], "mass": 36988.0, "length": 326, "protein_name": "Microtubule-associated protein RP/EB family member 2", "gene_name": "AABR07031491.2; Mapre2", "organism": "Rat", "refseq_name": "microtubule-associated protein RP/EB family member 2", "refseq_ac": [ { "id": "NP_001094470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094470", "type": "external" } ], "gene_names_uniprotkb": "AABR07031491.2; Mapre2; AABR07031491.2; Mapre2", "gene_names_refseq": "Mapre2", "protein_names_uniprotkb": "Microtubule-associated protein RP/EB family member 2", "protein_names_refseq": "microtubule-associated protein RP/EB family member 2-like; microtubule-associated protein RP/EB family member 2", "tax_id": 10116, "disease": "congenital symmetric circumferential skin creases 2 (Disease Ontology:DOID:0112243)", "pathway": " (rno:679221)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (By similarity). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation. Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0051010 microtubule plus-end binding", "go_cellular_component": "GO:0005925 focal adhesion;GO:0051233 spindle midzone;GO:0015630 microtubule cytoskeleton;GO:0005815 microtubule organizing center;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051301 cell division;GO:0051549 positive regulation of keratinocyte migration;GO:0051225 spindle assembly;GO:0035372 protein localization to microtubule", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3B8Q0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B8Q1-1", "uniprot_id": [ { "id": "DDX21_RAT", "url": "https://www.uniprot.org/uniprot/Q3B8Q1", "type": "external" } ], "mass": 85966.0, "length": 782, "protein_name": "Nucleolar RNA helicase 2", "gene_name": "Ddx21", "organism": "Rat", "refseq_name": "nucleolar RNA helicase 2", "refseq_ac": [ { "id": "NP_001032278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032278", "type": "external" } ], "gene_names_uniprotkb": "Ddx21; Ddx21a", "gene_names_refseq": "Ddx21a; Ddx21b; Ddx21", "protein_names_uniprotkb": "Nucleolar RNA helicase 2; 3.6.4.13; DEAD box protein 21; Gu-alpha; Nucleolar RNA helicase Gu; Nucleolar RNA helicase II; RH II/Gu", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box helicase 21; DEAD (Asp-Glu-Ala-Asp) box polypeptide 21a; DEAD (Asp-Glu-Ala-Asp) box polypeptide 21b; DEAD (Asp-Glu-Ala-Asp) box polypeptide 21; DEAD box protein 21; DEAD-box helicase 21; RH II/Gu; gu-alpha; nucleolar RNA helicase 2; nucleolar RNA helicase Gu; nucleolar RNA helicase II", "tax_id": 10116, "disease": "", "pathway": " (rno:317399); (R-RNO-5250924); (R-RNO-6791226)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes. In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes. Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77'. Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases. Involved in rRNA processing. May bind to specific miRNA hairpins (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0030515 snoRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0009615 response to virus;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3B8Q1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KR53-1", "uniprot_id": [ { "id": "GPBL1_RAT", "url": "https://www.uniprot.org/uniprot/Q3KR53", "type": "external" } ], "mass": 52432.0, "length": 475, "protein_name": "Vasculin-like protein 1", "gene_name": "Gpbp1l1", "organism": "Rat", "refseq_name": "vasculin-like protein 1", "refseq_ac": [ { "id": "NP_001030085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030085", "type": "external" } ], "gene_names_uniprotkb": "Gpbp1l1", "gene_names_refseq": "Gpbp1l1", "protein_names_uniprotkb": "Vasculin-like protein 1; GC-rich promoter-binding protein 1-like 1", "protein_names_refseq": "vasculin-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:313519)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Possible transcription factor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3KR53-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KRC6-1", "uniprot_id": [ { "id": "LRC8E_RAT", "url": "https://www.uniprot.org/uniprot/Q3KRC6", "type": "external" } ], "mass": 90445.0, "length": 795, "protein_name": "Volume-regulated anion channel subunit LRRC8E", "gene_name": "Lrrc8e", "organism": "Rat", "refseq_name": "volume-regulated anion channel subunit LRRC8E", "refseq_ac": [ { "id": "NP_001029311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029311", "type": "external" } ], "gene_names_uniprotkb": "Lrrc8e", "gene_names_refseq": "Lrrc8e; RGD1311979", "protein_names_uniprotkb": "Volume-regulated anion channel subunit LRRC8E; Leucine-rich repeat-containing protein 8E", "protein_names_refseq": "leucine rich repeat containing 8 family, member E; leucine-rich repeat-containing protein 8E; volume-regulated anion channel subunit LRRC8E", "tax_id": 10116, "disease": "", "pathway": " (rno:304203); (R-RNO-5223345)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "28833202", "class_list": "", "function": "Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:28833202). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress (By similarity). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:28833202). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005225 volume-sensitive anion channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0098656 monoatomic anion transmembrane transport;GO:0006884 cell volume homeostasis;GO:0071470 cellular response to osmotic stress;GO:0015810 aspartate transmembrane transport;GO:0140361 cyclic-GMP-AMP transmembrane import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3KRC6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q498R3-1", "uniprot_id": [ { "id": "DJC10_RAT", "url": "https://www.uniprot.org/uniprot/Q498R3", "type": "external" } ], "mass": 90747.0, "length": 793, "protein_name": "Endoplasmic reticulum disulfide reductase DNAJC10", "gene_name": "Dnajc10", "organism": "Rat", "refseq_name": "endoplasmic reticulum disulfide reductase DNAJC10 precursor", "refseq_ac": [ { "id": "NP_001099956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099956", "type": "external" } ], "gene_names_uniprotkb": "Dnajc10", "gene_names_refseq": "Dnajc10", "protein_names_uniprotkb": "Endoplasmic reticulum disulfide reductase DNAJC10; 1.8.4.2; DnaJ homolog subfamily C member 10", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 10; dnaJ homolog subfamily C member 10; endoplasmic reticulum disulfide reductase DNAJC10 precursor; endoplasmic reticulum disulfide reductase DNAJC10", "tax_id": 10116, "disease": "", "pathway": " (rno:295690)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "Endoplasmic reticulum disulfide reductase that collaborates directly with a BIP/HSPA5 (GRP78)-type chaperone to maintain protein quality control by facilitating either the correct folding or the targeted degradation of misfolded proteins., [UniProtKB, UniProtKB]; Endoplasmic reticulum disulfide reductase that collaborates directly with the chaperone BIP/HSPA5 (GRP78) to maintain protein quality control by facilitating either the correct folding or the targeted degradation of misfolded proteins. Essential for efficient maturation of newly synthesized polypeptides in the endoplasmic reticulum, binds to substrate proteins and specifically catalyzes the reduction and removal of improper (non-native) disulfide bonds during the folding process. In endoplasmic reticulum-associated degradation (ERAD), DNAJC10 reduces incorrect disulfide bonds specifically in misfolded glycoproteins that have been recognized by EDEM1, a key component of the ERAD pathway, thereby enabling their retrotranslocation and degradation. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.2", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" } ], "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity;GO:0019153 protein-disulfide reductase (glutathione) activity;GO:0051087 protein-folding chaperone binding;GO:0051117 ATPase binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0036498 IRE1-mediated unfolded protein response;GO:0036503 ERAD pathway;GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0034976 response to endoplasmic reticulum stress;GO:0034975 protein folding in endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q498R3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZV0-1", "uniprot_id": [ { "id": "MANBA_RAT", "url": "https://www.uniprot.org/uniprot/Q4FZV0", "type": "external" } ], "mass": 101221.0, "length": 881, "protein_name": "Beta-mannosidase", "gene_name": "Manba", "organism": "Rat", "refseq_name": "beta-mannosidase precursor", "refseq_ac": [ { "id": "NP_001026825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026825", "type": "external" } ], "gene_names_uniprotkb": "Manba", "gene_names_refseq": "Manba", "protein_names_uniprotkb": "Beta-mannosidase; 3.2.1.25; Lysosomal beta A mannosidase; Mannanase; Mannase", "protein_names_refseq": "beta-mannosidase precursor; beta-mannosidase; lysosomal beta A mannosidase; mannanase; mannase; mannosidase beta A; mannosidase, beta A, lysosomal", "tax_id": 10116, "disease": "beta-mannosidosis (Disease Ontology:DOID:3633)", "pathway": " (rno:310864); (R-RNO-6798695); (R-RNO-8853383)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosylhydrolase", "function": "Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q2NKP5", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0005537 D-mannose binding;GO:0004567 beta-mannosidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006516 glycoprotein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4FZV0-1", "record_type": "protein", "filter_code": "0000000.1000011.010000.000000000000001000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZX5-1", "uniprot_id": [ { "id": "MSRB2_RAT", "url": "https://www.uniprot.org/uniprot/Q4FZX5", "type": "external" } ], "mass": 19073.0, "length": 174, "protein_name": "Methionine-R-sulfoxide reductase B2, mitochondrial", "gene_name": "Msrb2", "organism": "Rat", "refseq_name": "methionine-R-sulfoxide reductase B2, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_001026830", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026830", "type": "external" } ], "gene_names_uniprotkb": "Msrb2", "gene_names_refseq": "Mrsb; Msrb2", "protein_names_uniprotkb": "Methionine-R-sulfoxide reductase B2, mitochondrial; 1.8.4.12; 1.8.4.14; MsrB2", "protein_names_refseq": "methionine-R-sulfoxide reductase B2, mitochondrial isoform 1; methionine-R-sulfoxide reductase B2, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:361286); (R-RNO-5676934)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.12", "type": "external" }, { "id": "1.8.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.14", "type": "external" } ], "go_molecular_function": "GO:0033743 peptide-methionine (R)-S-oxide reductase activity;GO:0033745 L-methionine-(R)-S-oxide reductase activity;GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0030041 actin filament polymerization;GO:0030091 protein repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4FZX5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLH9-1", "uniprot_id": [ { "id": "GPR4_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLH9", "type": "external" } ], "mass": 41267.0, "length": 365, "protein_name": "G protein-coupled receptor 4", "gene_name": "Gpr4", "organism": "Rat", "refseq_name": "G-protein coupled receptor 4", "refseq_ac": [ { "id": "NP_001020851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020851", "type": "external" } ], "gene_names_uniprotkb": "Gpr4", "gene_names_refseq": "Gpr4", "protein_names_uniprotkb": "G protein-coupled receptor 4", "protein_names_refseq": "G-protein coupled receptor 4", "tax_id": 10116, "disease": "", "pathway": " (rno:308408); (R-RNO-373076); (R-RNO-416476)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "29393594;29894771;31956173;32566653;38936540", "class_list": "", "function": "Interference with GPR4 inactivates NLRP3 inflammasome signaling by inhibiting LPAR1 expression to ameliorate oxygen-glucose deprivation/reoxygenation-induced inflammation and apoptosis of cardiomyocytes., [RefSeq, PubMed]; Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells., [RefSeq, PubMed]; Involvement of the G-Protein-Coupled Receptor 4 in the Increased Expression of RANK/RANKL/OPG System and Neurotrophins by Nucleus Pulposus Cells under the Degenerated Intervertebral Disc-Like Acidic Microenvironment. Publication Status: Online-Only, [RefSeq, PubMed]; Proton-sensing G protein-coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions. Activated by an optimal pH of 6.8-7.2. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. GPR4 is mainly coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. May also couple with G(i), G(q) and G(12)/G(13) G proteins (By similarity). Acts as a key regulator of respiratory sensitivity to CO2/H(+) in brain retrotrapezoid nucleus neurons: acts by mediating detection of protons generated by the formation of carbonic acid in the blood, an important mechanism to impulse to breathe (By similarity). Also acts as a regulator of acid secretion in the kidney collecting duct by maintaining acid-base homeostasis in the kidney. Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells, possibly through the G(12)/G(13)/Rho GTPase signaling pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results indicate that GPR4 is expressed by multiple neuronal populations and endothelium and that its pH sensitivity is affected by level of expression and l-lactic acid (LL). GPR4 antagonist NE 52-QQ57 blunts hypercapnic response to CO2 but this effect is absent under anaesthesia, possibly due to the inhibitory effect of LL on GPR4., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0030155 regulation of cell adhesion;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0043114 regulation of vascular permeability", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q4KLH9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM64-1", "uniprot_id": [ { "id": "JAGN1_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM64", "type": "external" } ], "mass": 21102.0, "length": 183, "protein_name": "Protein jagunal homolog 1", "gene_name": "Jagn1", "organism": "Rat", "refseq_name": "protein jagunal homolog 1", "refseq_ac": [ { "id": "NP_001037737", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037737", "type": "external" } ], "gene_names_uniprotkb": "Jagn1", "gene_names_refseq": "Jagn1", "protein_names_uniprotkb": "Protein jagunal homolog 1", "protein_names_refseq": "jagunal homolog 1; protein jagunal homolog 1", "tax_id": 10116, "disease": "severe congenital neutropenia 6 (Disease Ontology:DOID:0112134)", "pathway": " (rno:502872)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26882284", "class_list": "", "function": "Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils., [UniProtKB, UniProtKB, UniProtKB]; These results identify a novel role for Jagn1 in regulating proinsulin biosynthesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030223 neutrophil differentiation;GO:1901142 insulin metabolic process;GO:0002446 neutrophil mediated immunity;GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KM64-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM84-1", "uniprot_id": [ { "id": "MET18_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM84", "type": "external" } ], "mass": 40009.0, "length": 362, "protein_name": "Histidine protein methyltransferase 1 homolog", "gene_name": "Mettl18", "organism": "Rat", "refseq_name": "histidine protein methyltransferase 1 homolog", "refseq_ac": [ { "id": "NP_001020839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020839", "type": "external" } ], "gene_names_uniprotkb": "Mettl18", "gene_names_refseq": "Mettl18; RGD1306783", "protein_names_uniprotkb": "Histidine protein methyltransferase 1 homolog; 2.1.1.85; Methyltransferase-like protein 18", "protein_names_refseq": "histidine protein methyltransferase 1 homolog; methyltransferase 18, RPL3 N3-histidine; methyltransferase like 18; methyltransferase-like protein 18", "tax_id": 10116, "disease": "", "pathway": " (rno:304928)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3, thereby regulating translation elongation. Histidine methylation of RPL3 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.85", "type": "external" } ], "go_molecular_function": "GO:0031072 heat shock protein binding;GO:0018064 protein-L-histidine N-tele-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0005737 cytoplasm", "go_biological_process": "GO:2000232 regulation of rRNA processing;GO:0006417 regulation of translation;GO:0006448 regulation of translational elongation;GO:0018026 peptidyl-lysine monomethylation;GO:0090069 regulation of ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KM84-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM95-1", "uniprot_id": [ { "id": "LRC42_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM95", "type": "external" } ], "mass": 47914.0, "length": 421, "protein_name": "Leucine-rich repeat-containing protein 42", "gene_name": "Lrrc42", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 42", "refseq_ac": [ { "id": "NP_001020824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020824", "type": "external" } ], "gene_names_uniprotkb": "Lrrc42", "gene_names_refseq": "Lrrc42; RGD1308919", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 42", "protein_names_refseq": "leucine-rich repeat-containing protein 42", "tax_id": 10116, "disease": "", "pathway": " (rno:298309)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KM95-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQW4-1", "uniprot_id": [ { "id": "HDAC1_RAT", "url": "https://www.uniprot.org/uniprot/Q4QQW4", "type": "external" } ], "mass": 55093.0, "length": 482, "protein_name": "Histone deacetylase 1", "gene_name": "Hdac1", "organism": "Rat", "refseq_name": "histone deacetylase 1", "refseq_ac": [ { "id": "NP_001020580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020580", "type": "external" } ], "gene_names_uniprotkb": "Hdac1", "gene_names_refseq": "Hdac1", "protein_names_uniprotkb": "Histone deacetylase 1; 3.5.1.-; 3.5.1.98; HD1; Protein deacetylase HDAC1; Protein deacylase HDAC1", "protein_names_refseq": "HD1; histone deacetylase 1; protein deacetylase HDAC1; protein deacylase HDAC1; protein decrotonylase HDAC1", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); glaucoma (Disease Ontology:DOID:1686); multiple sclerosis (Disease Ontology:DOID:2377); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); pulmonary hypertension (Disease Ontology:DOID:6432); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:297893); (R-RNO-1538133); (R-RNO-201722); (R-RNO-2173795); (R-RNO-3214815); (R-RNO-350054); (R-RNO-3769402); (R-RNO-4551638); (R-RNO-6804758); (R-RNO-73762); (R-RNO-8936459); (R-RNO-8943724); (R-RNO-9018519); (R-RNO-9022692); (R-RNO-9701898); (R-RNO-9764725); (R-RNO-9824594); (R-RNO-9825892); (R-RNO-983231); (R-RNO-9937850); (R-RNO-9940951)", "pathway_count": 21, "publication_count": 8, "publication_id_list": "16641100;22673903;30980393;35172152;35853847;36542845;36921705;39007513", "class_list": "", "function": "Activation-induced chromatin reorganization in neurons depends on HDAC1 activity., [RefSeq, PubMed]; Endothelial histone deacetylase 1 activity impairs kidney microvascular NO signaling in rats fed a high-salt diet., [RefSeq, PubMed]; HDAC1 overexpression promoted by METTL3-IGF2BP2 inhibits FGF21 expression in metabolic syndrome-related liver injury., [RefSeq, PubMed]; Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Silencing EIF3A ameliorates pulmonary arterial hypertension through HDAC1 and PTEN/PI3K/AKT pathway in vitro and in vivo., [RefSeq, PubMed]; [(11)C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease. Erratum:[Nat Commun. 2022 Oct 3;13(1):5833. doi: 10.1038/s41467-022-33668-0. PMID: 36192402] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.9.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.-", "type": "external" }, { "id": "3.5.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.48", "type": "external" }, { "id": "3.5.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.62", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0035851 Krueppel-associated box domain binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0009913 epidermal cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q4QQW4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QR85-1", "uniprot_id": [ { "id": "MEP50_RAT", "url": "https://www.uniprot.org/uniprot/Q4QR85", "type": "external" } ], "mass": 37076.0, "length": 342, "protein_name": "Methylosome protein WDR77", "gene_name": "Wdr77", "organism": "Rat", "refseq_name": "methylosome protein WDR77", "refseq_ac": [ { "id": "NP_001008771", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008771", "type": "external" } ], "gene_names_uniprotkb": "Wdr77; Mep50", "gene_names_refseq": "Ac2-269; MEP-50; RGD1310479; Wdr77", "protein_names_uniprotkb": "Methylosome protein WDR77; MEP-50; Methylosome protein 50; WD repeat-containing protein 77", "protein_names_refseq": "WD repeat-containing protein 77; methylosome protein 50-like; methylosome protein 50; methylosome protein WDR77", "tax_id": 10116, "disease": "", "pathway": " (rno:310769); (R-RNO-191859); (R-RNO-3214858)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage., [UniProtKB, UniProtKB, UniProtKB]; Substrate-recognition component of the DCX(WDR77) complex, which mediates ubiquitination and degradation of Irgm in intestinal cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008327 methyl-CpG binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4QR85-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QR86-1", "uniprot_id": [ { "id": "DEPD7_RAT", "url": "https://www.uniprot.org/uniprot/Q4QR86", "type": "external" } ], "mass": 58201.0, "length": 511, "protein_name": "DEP domain-containing protein 7", "gene_name": "Depdc7", "organism": "Rat", "refseq_name": "DEP domain-containing protein 7 isoform 1", "refseq_ac": [ { "id": "NP_001025087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025087", "type": "external" } ], "gene_names_uniprotkb": "Depdc7", "gene_names_refseq": "Depdc7; RGD1309720", "protein_names_uniprotkb": "DEP domain-containing protein 7", "protein_names_refseq": "DEP domain-containing protein 7 isoform 1; DEP domain-containing protein 7", "tax_id": 10116, "disease": "", "pathway": " (rno:295971)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4QR86-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V793-1", "uniprot_id": [ { "id": "HIPK4_RAT", "url": "https://www.uniprot.org/uniprot/Q4V793", "type": "external" } ], "mass": 69298.0, "length": 616, "protein_name": "Homeodomain-interacting protein kinase 4", "gene_name": "Hipk4", "organism": "Rat", "refseq_name": "homeodomain-interacting protein kinase 4", "refseq_ac": [ { "id": "NP_001019947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019947", "type": "external" } ], "gene_names_uniprotkb": "Hipk4", "gene_names_refseq": "Hipk4", "protein_names_uniprotkb": "Homeodomain-interacting protein kinase 4; 2.7.11.1", "protein_names_refseq": "homeodomain-interacting protein kinase 4", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:308449)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0035173 histone kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:1901796 regulation of signal transduction by p53 class mediator;GO:0046777 protein autophosphorylation;GO:0018105 peptidyl-serine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V793-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7D3-1", "uniprot_id": [ { "id": "MACOI_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7D3", "type": "external" } ], "mass": 76082.0, "length": 664, "protein_name": "Macoilin", "gene_name": "Maco1", "organism": "Rat", "refseq_name": "macoilin", "refseq_ac": [ { "id": "NP_001020870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020870", "type": "external" } ], "gene_names_uniprotkb": "Maco1; Tmem57", "gene_names_refseq": "Maco1; Tmem57", "protein_names_uniprotkb": "Macoilin; Macoilin-1; Transmembrane protein 57", "protein_names_refseq": "macoilin; transmembrane protein 57", "tax_id": 10116, "disease": "", "pathway": " (rno:313618); (R-RNO-8980692); (R-RNO-9013106)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "22673903;38843836", "class_list": "", "function": "Plays a role in the regulation of neuronal activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q2TLZ0", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0030424 axon;GO:0031965 nuclear membrane;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:0023041 neuronal signal transduction;GO:0006935 chemotaxis;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4V7D3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7E8-1", "uniprot_id": [ { "id": "LRRF2_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7E8", "type": "external" } ], "mass": 49773.0, "length": 437, "protein_name": "Leucine-rich repeat flightless-interacting protein 2", "gene_name": "Lrrfip2", "organism": "Rat", "refseq_name": "leucine-rich repeat flightless-interacting protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001019932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019932", "type": "external" } ], "gene_names_uniprotkb": "Lrrfip2", "gene_names_refseq": "Lrrfip2", "protein_names_uniprotkb": "Leucine-rich repeat flightless-interacting protein 2; LRR FLII-interacting protein 2", "protein_names_refseq": "LRR FLII-interacting protein 2; leucine rich repeat (in FLII) interacting protein 2; leucine-rich repeat flightless-interacting protein 2 isoform 1; leucine-rich repeat flightless-interacting protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:301035)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030275 LRR domain binding", "go_cellular_component": "", "go_biological_process": "GO:0035660 MyD88-dependent toll-like receptor 4 signaling pathway;GO:0006355 regulation of DNA-templated transcription;GO:0016055 Wnt signaling pathway;GO:0032760 positive regulation of tumor necrosis factor production;GO:0002756 MyD88-independent toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V7E8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V889-1", "uniprot_id": [ { "id": "Q4V889_RAT", "url": "https://www.uniprot.org/uniprot/Q4V889", "type": "external" } ], "mass": 66968.0, "length": 603, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "Rlim", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RLIM", "refseq_ac": [ { "id": "NP_001020063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020063", "type": "external" } ], "gene_names_uniprotkb": "Rlim", "gene_names_refseq": "Rliml1; Rlim; Rnf12", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase RLIM; ring finger protein 12; ring finger protein, LIM domain interacting-like 1", "tax_id": 10116, "disease": "Tonne-Kalscheuer syndrome (Disease Ontology:DOID:0112042)", "pathway": " (rno:317241); (R-RNO-983168)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "29393594;30988473", "class_list": "", "function": "A novel approach to differentiate rat embryonic stem cells in vitro reveals a role for RNF12 in activation of X chromosome inactivation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D4A8S6", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0060816 random inactivation of X chromosome;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0050767 regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4V889-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8B3-1", "uniprot_id": [ { "id": "MED24_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8B3", "type": "external" } ], "mass": 110081.0, "length": 987, "protein_name": "Mediator of RNA polymerase II transcription subunit 24", "gene_name": "Med24", "organism": "Rat", "refseq_name": "mediator of RNA polymerase II transcription subunit 24", "refseq_ac": [ { "id": "NP_001029251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029251", "type": "external" } ], "gene_names_uniprotkb": "Med24; Thrap4", "gene_names_refseq": "Med24; Thrap4", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 24; Mediator complex subunit 24; Thyroid hormone receptor-associated protein 4", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 24; thyroid hormone receptor-associated protein 4", "tax_id": 10116, "disease": "Hirschsprung's disease (Disease Ontology:DOID:10487); intestinal disease (Disease Ontology:DOID:5295); neuropathy (Disease Ontology:DOID:870)", "pathway": " (rno:619436); (R-RNO-9841922)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0044877 protein-containing complex binding;GO:0046966 nuclear thyroid hormone receptor binding;GO:0003712 transcription coregulator activity;GO:0004402 histone acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000151 ubiquitin ligase complex;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0006366 transcription by RNA polymerase II;GO:0019827 stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8B3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8B4-1", "uniprot_id": [ { "id": "Q4V8B4_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8B4", "type": "external" } ], "mass": 62734.0, "length": 572, "protein_name": "Chromatin assembly factor 1 subunit B", "gene_name": "Chaf1b", "organism": "Rat", "refseq_name": "chromatin assembly factor 1 subunit B", "refseq_ac": [ { "id": "NP_001019912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019912", "type": "external" } ], "gene_names_uniprotkb": "Chaf1b", "gene_names_refseq": "Chaf1b", "protein_names_uniprotkb": "Chromatin assembly factor 1 subunit B; Chromatin assembly factor I p60 subunit", "protein_names_refseq": "chromatin assembly factor 1 subunit B; chromatin assembly factor 1, subunit B (p60)", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); prostate cancer (Disease Ontology:DOID:10283); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (rno:288242)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;34626773", "class_list": "", "function": "Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer., [UniProtKB, UniProtKB, UniProtKB]; DNA methylation mediated downregulation of histone H3 variant H3.3 affects cell proliferation contributing to the development of HCC., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0006334 nucleosome assembly;GO:0006335 DNA replication-dependent chromatin assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4V8B4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8E5-1", "uniprot_id": [ { "id": "S33A2_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8E5", "type": "external" } ], "mass": 43513.0, "length": 416, "protein_name": "Solute carrier family 33 member 2", "gene_name": "Slc33a2", "organism": "Rat", "refseq_name": "solute carrier family 33 member 2", "refseq_ac": [ { "id": "NP_001020079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020079", "type": "external" } ], "gene_names_uniprotkb": "Slc33a2; Mfsd3", "gene_names_refseq": "Mfsd3; Slc33a2", "protein_names_uniprotkb": "Solute carrier family 33 member 2; Major facilitator superfamily domain-containing protein 3", "protein_names_refseq": "major facilitator superfamily domain containing 3; major facilitator superfamily domain-containing protein 3; solute carrier family 33 member 2", "tax_id": 10116, "disease": "", "pathway": " (rno:500899)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8E5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8E6-1", "uniprot_id": [ { "id": "GSTT4_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8E6", "type": "external" } ], "mass": 27970.0, "length": 240, "protein_name": "Glutathione S-transferase theta-4", "gene_name": "Gstt4", "organism": "Rat", "refseq_name": "glutathione S-transferase theta-4", "refseq_ac": [ { "id": "NP_001103145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103145", "type": "external" } ], "gene_names_uniprotkb": "Gstt4", "gene_names_refseq": "Gstt4", "protein_names_uniprotkb": "Glutathione S-transferase theta-4; 2.5.1.18; GST class-theta-4", "protein_names_refseq": "GST class-theta-4; glutathione S-transferase theta-4", "tax_id": 10116, "disease": "", "pathway": " (rno:686922)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8E6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8K3-1", "uniprot_id": [ { "id": "NAA11_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8K3", "type": "external" } ], "mass": 27623.0, "length": 246, "protein_name": "N-alpha-acetyltransferase 11", "gene_name": "Naa11", "organism": "Rat", "refseq_name": "N-alpha-acetyltransferase 11", "refseq_ac": [ { "id": "NP_001019913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019913", "type": "external" } ], "gene_names_uniprotkb": "Naa11; Ard1b; Ard2", "gene_names_refseq": "Ard1b; Naa11", "protein_names_uniprotkb": "N-alpha-acetyltransferase 11; 2.3.1.255; N-terminal acetyltransferase complex ARD1 subunit homolog B; NatA catalytic subunit Naa11", "protein_names_refseq": "Ard2; N-alpha-acetyltransferase 11; N-terminal acetyltransferase complex ARD1 subunit homolog B; alpha-N-acetyltransferase 1B; natA catalytic subunit Naa11", "tax_id": 10116, "disease": "Ogden syndrome (Disease Ontology:DOID:0050781)", "pathway": " (rno:289482)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16638120", "class_list": "", "function": "Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.255", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.255", "type": "external" } ], "go_molecular_function": "GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:1990189 protein N-terminal-serine acetyltransferase activity;GO:1990190 protein-N-terminal-glutamate acetyltransferase activity;GO:0008999 protein-N-terminal-alanine acetyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0031415 NatA complex", "go_biological_process": "GO:0006474 N-terminal protein amino acid acetylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8K3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q562C4-1", "uniprot_id": [ { "id": "TMT1B_RAT", "url": "https://www.uniprot.org/uniprot/Q562C4", "type": "external" } ], "mass": 27904.0, "length": 244, "protein_name": "Thiol S-methyltransferase TMT1B", "gene_name": "Tmt1b", "organism": "Rat", "refseq_name": "thiol S-methyltransferase TMT1B precursor", "refseq_ac": [ { "id": "NP_001019447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019447", "type": "external" } ], "gene_names_uniprotkb": "Tmt1b; Mettl7b", "gene_names_refseq": "Mettl7b; RGD1305205; Tmt1b", "protein_names_uniprotkb": "Thiol S-methyltransferase TMT1B; 2.1.1.9; ALDI; Associated with lipid droplet protein 1; Methyltransferase-like protein 7B; Thiol S-methyltransferase METTL7B", "protein_names_refseq": "ALDI; associated with lipid droplet protein 1; methyltransferase like 7B; methyltransferase-like protein 7B; thiol S-methyltransferase METTL7B; thiol S-methyltransferase TMT1B precursor; thiol S-methyltransferase TMT1B", "tax_id": 10116, "disease": "", "pathway": " (rno:366792)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17004324;33649426", "class_list": "", "function": "Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes. Selectively methylates S-centered nucleophiles from metabolites such as hydrogen sulfide and dithiothreitol., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.9", "type": "external" } ], "go_molecular_function": "GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0018708 thiol S-methyltransferase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q562C4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q562C6-1", "uniprot_id": [ { "id": "LZTL1_RAT", "url": "https://www.uniprot.org/uniprot/Q562C6", "type": "external" } ], "mass": 34638.0, "length": 299, "protein_name": "Leucine zipper transcription factor-like protein 1", "gene_name": "Lztfl1", "organism": "Rat", "refseq_name": "leucine zipper transcription factor-like protein 1", "refseq_ac": [ { "id": "NP_001019437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019437", "type": "external" } ], "gene_names_uniprotkb": "Lztfl1", "gene_names_refseq": "Lztfl1", "protein_names_uniprotkb": "Leucine zipper transcription factor-like protein 1", "protein_names_refseq": "leucine zipper transcription factor-like protein 1", "tax_id": 10116, "disease": "Bardet-Biedl syndrome 17 (Disease Ontology:DOID:0110139)", "pathway": " (rno:316102); (R-RNO-5620922)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0002177 manchette", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:1903565 negative regulation of protein localization to cilium;GO:1903568 negative regulation of protein localization to ciliary membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q562C6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q562C9-1", "uniprot_id": [ { "id": "MTND_RAT", "url": "https://www.uniprot.org/uniprot/Q562C9", "type": "external" } ], "mass": 21461.0, "length": 179, "protein_name": "Acireductone dioxygenase", "gene_name": "Adi1", "organism": "Rat", "refseq_name": "acireductone dioxygenase", "refseq_ac": [ { "id": "NP_954528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954528", "type": "external" } ], "gene_names_uniprotkb": "Adi1; ADI1; Alp1; MTCBP1; Mtcbp1", "gene_names_refseq": "ARD'; Adi1; Alp1; Fe-ARD; MTCBP-1; Ni-ARD", "protein_names_uniprotkb": "Acireductone dioxygenase; 1.13.11.53; 1.13.11.54; ARD'; ARD; Acireductone dioxygenase (Fe(2+)-requiring); Acireductone dioxygenase (Ni(2+)-requiring); Androgen-responsive ARD-like protein 1; Fe-ARD; MTCBP-1; Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1; Ni-ARD", "protein_names_refseq": "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; aci-reductone dioxygenase (ARD)-like protein 1; acireductone dioxygenase (Fe(2+)-requiring); acireductone dioxygenase (Ni(2+)-requiring); acireductone dioxygenase; androgen-responsive ARD-like protein 1; androgen-responsive gene encoding an ARD-like protein; membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:298934); (R-RNO-1237112)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "14684610", "class_list": "", "function": "Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14., [UniProtKB, HAMAP, UniProtKB]; May have an important role in androgen regulated prostate homeostasis as well as in prostate cancer progression by regulating cell death of prostate cancer cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6V9S4", "ec_number_list": [ { "id": "1.13.11.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.54", "type": "external" }, { "id": "1.13.11.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.53", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0016151 nickel cation binding;GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity;GO:0010308 acireductone dioxygenase (Ni2+-requiring) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0019509 L-methionine salvage from methylthioadenosine;GO:0006555 methionine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q562C9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q569C4-1", "uniprot_id": [ { "id": "HDA10_RAT", "url": "https://www.uniprot.org/uniprot/Q569C4", "type": "external" } ], "mass": 63957.0, "length": 588, "protein_name": "Polyamine deacetylase HDAC10", "gene_name": "Hdac10", "organism": "Rat", "refseq_name": "polyamine deacetylase HDAC10 isoform 2", "refseq_ac": [ { "id": "NP_001030172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030172", "type": "external" } ], "gene_names_uniprotkb": "Hdac10", "gene_names_refseq": "Hdac10", "protein_names_uniprotkb": "Polyamine deacetylase HDAC10; 3.5.1.48; 3.5.1.62; HD10; Histone deacetylase 10", "protein_names_refseq": "HD10; polyamine deacetylase HDAC10 isoform 2; polyamine deacetylase HDAC10", "tax_id": 10116, "disease": "", "pathway": " (rno:362981); (R-RNO-3214815); (R-RNO-350054)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "32112918", "class_list": "", "function": "Histone Deacetylation 10 Alleviates Inflammation After Intracerebral Hemorrhage via the PTPN22/NLRP3 Pathway in Rats., [RefSeq, PubMed]; Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. May play a role in homologous recombination. May promote DNA mismatch repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.5.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.48", "type": "external" }, { "id": "3.5.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.62", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042826 histone deacetylase binding;GO:0019213 deacetylase activity;GO:0004407 histone deacetylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0032425 positive regulation of mismatch repair;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006355 regulation of DNA-templated transcription;GO:0016236 macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q569C4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q58NB7-1", "uniprot_id": [ { "id": "Q58NB7_RAT", "url": "https://www.uniprot.org/uniprot/Q58NB7", "type": "external" } ], "mass": 31953.0, "length": 284, "protein_name": "Retinoic acid receptor responder 1", "gene_name": "Rarres1", "organism": "Rat", "refseq_name": "retinoic acid receptor responder protein 1 precursor", "refseq_ac": [ { "id": "NP_001014790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014790", "type": "external" } ], "gene_names_uniprotkb": "Rarres1", "gene_names_refseq": "Rarres1", "protein_names_uniprotkb": "Retinoic acid receptor responder 1", "protein_names_refseq": "retinoic acid receptor responder (tazarotene induced) 1; retinoic acid receptor responder protein 1 precursor; retinoic acid receptor responder protein 1; tazarotene-induced protein 1", "tax_id": 10116, "disease": "follicular lymphoma (Disease Ontology:DOID:0050873)", "pathway": " (rno:310486)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22669512;29393594;31905805", "class_list": "", "function": "Data demonstrated an increase in RARRES1 expression in a rat lung fibrosis model induced by adenoviral TGF-beta1 induction., [RefSeq, PubMed]; RARRES1 and 2 may have different expression and roles in human and rodent placentas, thereby underlining immanent limitations of comparative interspecies placentology. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6J5L7", "ec_number_list": [], "go_molecular_function": "GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q58NB7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJP1-1", "uniprot_id": [ { "id": "Q5BJP1_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJP1", "type": "external" } ], "mass": 47508.0, "length": 436, "protein_name": "PBX/knotted 1 homeobox 1", "gene_name": "Pknox1", "organism": "Rat", "refseq_name": "homeobox protein PKNOX1 isoform 1", "refseq_ac": [ { "id": "NP_001013092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013092", "type": "external" } ], "gene_names_uniprotkb": "Pknox1", "gene_names_refseq": "Pknox1", "protein_names_uniprotkb": "PBX/knotted 1 homeobox 1", "protein_names_refseq": "homeobox protein PKNOX1 isoform 1; homeobox protein PKNOX1", "tax_id": 10116, "disease": "", "pathway": " (rno:294322)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30338914", "class_list": "", "function": "These data implicate the upregulated hepatic expression of Pknox1 in type 2 diabetes mellitus (T2DM) complicated with nonalcoholic fatty liver disease (NAFLD) may be caused by the reduced expression of miR-17 family, indicating that developing miRNA-mediated regulation strategies on Pknox1 may provide new therapeutic options for metabolic disease, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030218 erythrocyte differentiation;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BJP1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJQ2-1", "uniprot_id": [ { "id": "MINY1_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJQ2", "type": "external" } ], "mass": 52729.0, "length": 482, "protein_name": "Ubiquitin carboxyl-terminal hydrolase MINDY-1", "gene_name": "Mindy1", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase MINDY-1", "refseq_ac": [ { "id": "NP_001020289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020289", "type": "external" } ], "gene_names_uniprotkb": "Mindy1; Fam63a", "gene_names_refseq": "Fam63a; Mindy1", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase MINDY-1; 3.4.19.12; Deubiquitinating enzyme MINDY-1; Protein FAM63A", "protein_names_refseq": "deubiquitinating enzyme MINDY-1; family with sequence similarity 63, member A; protein FAM63A; ubiquitin carboxyl-terminal hydrolase MINDY-1", "tax_id": 10116, "disease": "", "pathway": " (rno:310665)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0016807 cysteine-type carboxypeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJQ2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJY9-1", "uniprot_id": [ { "id": "K1C18_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJY9", "type": "external" } ], "mass": 47761.0, "length": 423, "protein_name": "Keratin, type I cytoskeletal 18", "gene_name": "Krt18", "organism": "Rat", "refseq_name": "keratin, type I cytoskeletal 18", "refseq_ac": [ { "id": "NP_446428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446428", "type": "external" } ], "gene_names_uniprotkb": "Krt18; Krt1-18", "gene_names_refseq": "Krt1-18; Krt18", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 18; CK-18; Cytokeratin-18; K18; Keratin-18", "protein_names_refseq": "CK-18; K18; cytokeratin-18; keratin 18, type I; keratin complex 1, acidic, gene 18; keratin, type I cytoskeletal 18", "tax_id": 10116, "disease": "primary sclerosing cholangitis (Disease Ontology:DOID:0060643); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); primary biliary cholangitis (Disease Ontology:DOID:12236); liver disease (Disease Ontology:DOID:409); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:294853); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10707864;11428046;14630065;16128803;16641100;1691189;16998620;22673903;36395917;7507868;7514933;7517927;7589899;8541209;8789401;8824732;9353322", "class_list": "", "function": "Keratin 18 Depletion as a Possible Mechanism for the Induction of Apoptosis and Ferroptosis in the Rat Hippocampus After Hypobaric Hypoxia., [RefSeq, PubMed]; Structural component of intermediate filaments in epithelial cells. Forms obligate heteropolymers with a type II keratin KRT8, mechanical stability and resilience to epithelial cells (PubMed:1691189). KRT8/KRT18 filaments are involved in ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement (By similarity). Organization and orientation of KRT18 filaments are responsible for the properly elongated morphology of epithelial tubules (By similarity). Also acts downstream of ROCK kinase activation as part of a positive feedback mechanism in response to cellular mechanical stress loading (By similarity). Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (PubMed:9353322). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane (By similarity). Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q63278", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0031667 response to nutrient levels;GO:0097191 extrinsic apoptotic signaling pathway;GO:0043001 Golgi to plasma membrane protein transport;GO:0033209 tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q5BJY9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK01-1", "uniprot_id": [ { "id": "MET24_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK01", "type": "external" } ], "mass": 40967.0, "length": 363, "protein_name": "Probable methyltransferase-like protein 24", "gene_name": "Mettl24", "organism": "Rat", "refseq_name": "probable methyltransferase-like protein 24 precursor", "refseq_ac": [ { "id": "NP_001020209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020209", "type": "external" } ], "gene_names_uniprotkb": "Mettl24", "gene_names_refseq": "Mettl24", "protein_names_uniprotkb": "Probable methyltransferase-like protein 24; 2.1.1.-", "protein_names_refseq": "UPF0624 protein C6orf186 homolog; methyltransferase-like protein 24; probable methyltransferase-like protein 24 precursor; probable methyltransferase-like protein 24", "tax_id": 10116, "disease": "", "pathway": " (rno:499465)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable methyltransferase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK01-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK17-1", "uniprot_id": [ { "id": "IYD1_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK17", "type": "external" } ], "mass": 32846.0, "length": 285, "protein_name": "Iodotyrosine deiodinase 1", "gene_name": "Iyd", "organism": "Rat", "refseq_name": "iodotyrosine deiodinase 1", "refseq_ac": [ { "id": "NP_001020171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020171", "type": "external" } ], "gene_names_uniprotkb": "Iyd; Dehal1", "gene_names_refseq": "Iyd; RGD1309288", "protein_names_uniprotkb": "Iodotyrosine deiodinase 1; 1.21.1.1; IYD-1; Iodotyrosine dehalogenase 1", "protein_names_refseq": "IYD-1; iodotyrosine dehalogenase 1; iodotyrosine deiodinase 1", "tax_id": 10116, "disease": "thyroid dyshormonogenesis 4 (Disease Ontology:DOID:0112188)", "pathway": " (rno:308129); (R-RNO-209968)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "25850545", "class_list": "", "function": "Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine. During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT). The scavanged iodide can then reenter the hormone-producing pathways. Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine., [UniProtKB, UniProtKB]; Iodine deficiency results in an increased expression of IYD in thyroid, whereas excess iodine decreases the expression of thyroidal IYD., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.21.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.21.1.1", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0010181 FMN binding;GO:0140616 iodotyrosine deiodinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0042403 thyroid hormone metabolic process;GO:0006570 tyrosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BK17-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK22-1", "uniprot_id": [ { "id": "GTPB8_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK22", "type": "external" } ], "mass": 32232.0, "length": 285, "protein_name": "GTP-binding protein 8", "gene_name": "Gtpbp8", "organism": "Rat", "refseq_name": "GTP-binding protein 8", "refseq_ac": [ { "id": "NP_001020186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020186", "type": "external" } ], "gene_names_uniprotkb": "Gtpbp8", "gene_names_refseq": "Gtpbp8; RGD1310025", "protein_names_uniprotkb": "GTP-binding protein 8", "protein_names_refseq": "GTP-binding protein 8 (putative); GTP-binding protein 8", "tax_id": 10116, "disease": "", "pathway": " (rno:360714)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK22-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVJ5-1", "uniprot_id": [ { "id": "MERB1_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVJ5", "type": "external" } ], "mass": 23420.0, "length": 203, "protein_name": "bMERB domain-containing protein 1", "gene_name": "Bmerb1", "organism": "Rat", "refseq_name": "bMERB domain-containing protein 1", "refseq_ac": [ { "id": "NP_001014136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014136", "type": "external" } ], "gene_names_uniprotkb": "Bmerb1", "gene_names_refseq": "Bmerb1; RGD1305733", "protein_names_uniprotkb": "bMERB domain-containing protein 1; Uncharacterized protein C16orf45 homolog", "protein_names_refseq": "bMERB domain-containing protein 1; uncharacterized protein C16orf45 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:360459)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0021822 negative regulation of cell motility involved in cerebral cortex radial glia guided migration;GO:0007026 negative regulation of microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVJ5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVM7-1", "uniprot_id": [ { "id": "DJC16_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVM7", "type": "external" } ], "mass": 88870.0, "length": 771, "protein_name": "DnaJ homolog subfamily C member 16", "gene_name": "Dnajc16", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily C member 16 precursor", "refseq_ac": [ { "id": "NP_001014216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014216", "type": "external" } ], "gene_names_uniprotkb": "Dnajc16; Erdj8", "gene_names_refseq": "Dnajc16; ERdj8", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 16; ER-resident protein ERdj8; ERdj8; Endoplasmic reticulum DNA J domain-containing protein 8", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 16; ER-resident protein ERdj8; dnaJ homolog subfamily C member 16 precursor; dnaJ homolog subfamily C member 16; endoplasmic reticulum DNA J domain-containing protein 8", "tax_id": 10116, "disease": "", "pathway": " (rno:362652)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Plays an important role in regulating the size of autophagosomes during the formation process., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016243 regulation of autophagosome size;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FVM7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVQ4-1", "uniprot_id": [ { "id": "MLEC_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVQ4", "type": "external" } ], "mass": 32418.0, "length": 291, "protein_name": "Malectin", "gene_name": "Mlec", "organism": "Rat", "refseq_name": "malectin precursor", "refseq_ac": [ { "id": "NP_001014005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014005", "type": "external" } ], "gene_names_uniprotkb": "Mlec", "gene_names_refseq": "Mlec; RGD1307736", "protein_names_uniprotkb": "Malectin", "protein_names_refseq": "malectin precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:304543); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0051087 protein-folding chaperone binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVQ4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FWT5-1", "uniprot_id": [ { "id": "GATA_RAT", "url": "https://www.uniprot.org/uniprot/Q5FWT5", "type": "external" } ], "mass": 56838.0, "length": 525, "protein_name": "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial", "gene_name": "Qrsl1", "organism": "Rat", "refseq_name": "glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial", "refseq_ac": [ { "id": "NP_001014056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014056", "type": "external" } ], "gene_names_uniprotkb": "Qrsl1; QRSL1", "gene_names_refseq": "Qrsl1", "protein_names_uniprotkb": "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; 6.3.5.7; Glu-AdT subunit A; Glutaminyl-tRNA synthase-like protein 1", "protein_names_refseq": "QRSL1, glutaminyl-tRNA amidotransferase subunit A; glu-AdT subunit A; glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1; glutaminyl-tRNA synthase-like protein 1; glutamyl-tRNA(Gln) amidotransferase subunit A homolog; glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); combined oxidative phosphorylation deficiency 40 (Disease Ontology:DOID:0112117)", "pathway": " (rno:309911)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.-", "type": "external" }, { "id": "6.3.5.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.7", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex", "go_biological_process": "GO:0031647 regulation of protein stability;GO:0032543 mitochondrial translation;GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FWT5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5HZE0-1", "uniprot_id": [ { "id": "S2529_RAT", "url": "https://www.uniprot.org/uniprot/Q5HZE0", "type": "external" } ], "mass": 32635.0, "length": 306, "protein_name": "Mitochondrial basic amino acids transporter", "gene_name": "Slc25a29", "organism": "Rat", "refseq_name": "mitochondrial basic amino acids transporter", "refseq_ac": [ { "id": "NP_001010958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010958", "type": "external" } ], "gene_names_uniprotkb": "Slc25a29; Ornt3", "gene_names_refseq": "Slc25a29", "protein_names_uniprotkb": "Mitochondrial basic amino acids transporter; CACT-like; Carnitine/acylcarnitine translocase-like; Mitochondrial carnitine/acylcarnitine carrier protein CACL; Mitochondrial ornithine transporter 3; Solute carrier family 25 member 29", "protein_names_refseq": "carnitine/acylcarnitine translocase-like; mitochondrial basic amino acids transporter; mitochondrial carnitine/acylcarnitine carrier protein CACL; mitochondrial ornithine transporter 3; solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29; solute carrier family 25 (mitochondrial carrier, palmitoylcarnitine transporter), member 29", "tax_id": 10116, "disease": "", "pathway": " (rno:314441); (R-RNO-352230)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial transporter of arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms. Plays a physiological role in the import of basic amino acids into mitochondria for mitochondrial protein synthesis and amino acid degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005289 high-affinity L-arginine transmembrane transporter activity;GO:0005292 high-affinity lysine transmembrane transporter activity;GO:0015174 basic amino acid transmembrane transporter activity;GO:0015227 O-acyl-L-carnitine transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015822 ornithine transport;GO:0089709 L-histidine transmembrane transport;GO:1903401 L-lysine transmembrane transport;GO:1990575 mitochondrial L-ornithine transmembrane transport;GO:1903826 L-arginine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5HZE0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0G4-1", "uniprot_id": [ { "id": "GARS_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0G4", "type": "external" } ], "mass": 81793.0, "length": 728, "protein_name": "Glycine--tRNA ligase", "gene_name": "Gars1", "organism": "Rat", "refseq_name": "glycine--tRNA ligase", "refseq_ac": [ { "id": "NP_001258068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258068", "type": "external" } ], "gene_names_uniprotkb": "Gars1; Gars", "gene_names_refseq": "Gars1; GlyRS; RGD1559871", "protein_names_uniprotkb": "Glycine--tRNA ligase; 2.7.7.-; 6.1.1.14; Ap4A synthetase; Diadenosine tetraphosphate synthetase; GlyRS; Glycyl-tRNA synthetase 1; Glycyl-tRNA synthetase", "protein_names_refseq": "AP-4-A synthetase; ap4A synthetase; diadenosine tetraphosphate synthetase; glycine--tRNA ligase", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease type 2 (Disease Ontology:DOID:0050539); Charcot-Marie-Tooth disease type 2D (Disease Ontology:DOID:0110164); autosomal dominant distal hereditary motor neuronopathy 5 (Disease Ontology:DOID:0111203); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); spinal muscular atrophy (Disease Ontology:DOID:12377)", "pathway": " (rno:297113)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V7G8", "ec_number_list": [ { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.1.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.14", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0004081 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity;GO:0004820 glycine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0030141 secretory granule;GO:0030424 axon", "go_biological_process": "GO:0015966 diadenosine tetraphosphate biosynthetic process;GO:0006418 tRNA aminoacylation for protein translation;GO:0070150 mitochondrial glycyl-tRNA aminoacylation;GO:0006426 glycyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5I0G4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0J5-1", "uniprot_id": [ { "id": "MITD1_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0J5", "type": "external" } ], "mass": 28849.0, "length": 249, "protein_name": "MIT domain-containing protein 1", "gene_name": "Mitd1", "organism": "Rat", "refseq_name": "MIT domain-containing protein 1", "refseq_ac": [ { "id": "NP_001009714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009714", "type": "external" } ], "gene_names_uniprotkb": "Mitd1", "gene_names_refseq": "Mitd1; RGD1307700", "protein_names_uniprotkb": "MIT domain-containing protein 1", "protein_names_refseq": "MIT domain-containing protein 1; MIT, microtubule interacting and transport, domain containing 1", "tax_id": 10116, "disease": "", "pathway": " (rno:363219)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT complexes. Does not seem to be involved in endosomal transport (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0016020 membrane;GO:0031902 late endosome membrane;GO:0030496 midbody", "go_biological_process": "GO:0000281 mitotic cytokinesis;GO:0061952 midbody abscission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0J5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5KTC7-1", "uniprot_id": [ { "id": "NAAA_RAT", "url": "https://www.uniprot.org/uniprot/Q5KTC7", "type": "external" } ], "mass": 40313.0, "length": 362, "protein_name": "N-acylethanolamine-hydrolyzing acid amidase", "gene_name": "Naaa", "organism": "Rat", "refseq_name": "N-acylethanolamine-hydrolyzing acid amidase precursor", "refseq_ac": [ { "id": "NP_001010967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010967", "type": "external" } ], "gene_names_uniprotkb": "Naaa; Asahl", "gene_names_refseq": "Asahl; Naaa", "protein_names_uniprotkb": "N-acylethanolamine-hydrolyzing acid amidase; 3.5.1.23; 3.5.1.60; ASAH-like protein; Acylsphingosine deacylase NAAA; N-acylsphingosine amidohydrolase-like", "protein_names_refseq": "ASAH-like protein; N-acylethanolamine-hydrolyzing acid amidase precursor; N-acylethanolamine-hydrolyzing acid amidase; acylsphingosine deacylase NAAA", "tax_id": 10116, "disease": "", "pathway": " (rno:497009); (R-RNO-112310)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11463796;15655246;17462942;22860206;29393594;31063807", "class_list": "", "function": "Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-stearoylethanolamine > N-oleoylethanolamine > N-linoleoylethanolamine > N-arachidonoylethanolamine., [UniProtKB, PubMed, PubMed, PubMed]; MRNA and protein levels and activity of NAAA in alveolar macrophages are much higher than those in the whole lung tissue., [RefSeq, PubMed]; Taken together, this study identified the association between NAAA and steoarthritis (OA) progression, and suggested that NAAA inhibitors could be a novel therapeutic approach for OA., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3KRD3", "ec_number_list": [ { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.60", "type": "external" } ], "go_molecular_function": "GO:0017064 fatty acid amide hydrolase activity;GO:0017040 N-acylsphingosine amidohydrolase activity;GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0047412 N-(long-chain-acyl)ethanolamine deacylase activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0070291 N-acylethanolamine metabolic process;GO:0006670 sphingosine metabolic process;GO:0006631 fatty acid metabolic process;GO:0016042 lipid catabolic process;GO:0070292 N-acylphosphatidylethanolamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5KTC7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M939-1", "uniprot_id": [ { "id": "HAT1_RAT", "url": "https://www.uniprot.org/uniprot/Q5M939", "type": "external" } ], "mass": 49241.0, "length": 419, "protein_name": "Histone acetyltransferase type B catalytic subunit", "gene_name": "Hat1", "organism": "Rat", "refseq_name": "histone acetyltransferase type B catalytic subunit", "refseq_ac": [ { "id": "NP_001009657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009657", "type": "external" } ], "gene_names_uniprotkb": "Hat1", "gene_names_refseq": "Hat1", "protein_names_uniprotkb": "Histone acetyltransferase type B catalytic subunit; 2.3.1.-; 2.3.1.48; Histone acetyltransferase 1; Histone methacryltransferase HAT1", "protein_names_refseq": "histone acetyltransferase type B catalytic subunit; histone aminotransferase 1; histone methacryltransferase HAT1", "tax_id": 10116, "disease": "", "pathway": " (rno:296501); (R-RNO-3214847)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "32506381", "class_list": "", "function": "Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The Expression and Localization of Histone Acetyltransferases HAT1 and PCAF in Neurons and Astrocytes of the Photothrombotic Stroke-Induced Penumbra in the Rat Brain Cortex., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" } ], "go_molecular_function": "GO:0043997 histone H4K12 acetyltransferase activity;GO:0042393 histone binding;GO:0010485 histone H4 acetyltransferase activity;GO:0140218 histone methacryltransferase activity;GO:0004402 histone acetyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0016363 nuclear matrix;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0007584 response to nutrient;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M939-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M9I6-1", "uniprot_id": [ { "id": "MMTA2_RAT", "url": "https://www.uniprot.org/uniprot/Q5M9I6", "type": "external" } ], "mass": 29300.0, "length": 260, "protein_name": "Multiple myeloma tumor-associated protein 2 homolog", "gene_name": "C10h1orf35; Mmtag2", "organism": "Rat", "refseq_name": "multiple myeloma tumor-associated protein 2 homolog", "refseq_ac": [ { "id": "NP_001094021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094021", "type": "external" } ], "gene_names_uniprotkb": "C10h1orf35; Mmtag2", "gene_names_refseq": "C10h1orf35; Mmtag2; RGD1304587", "protein_names_uniprotkb": "Multiple myeloma tumor-associated protein 2 homolog", "protein_names_refseq": "multiple myeloma tumor-associated protein 2 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:303180); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M9I6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPL2-1", "uniprot_id": [ { "id": "DCNL5_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPL2", "type": "external" } ], "mass": 27568.0, "length": 237, "protein_name": "DCN1-like protein 5", "gene_name": "Dcun1d5", "organism": "Rat", "refseq_name": "DCN1-like protein 5", "refseq_ac": [ { "id": "NP_001009696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009696", "type": "external" } ], "gene_names_uniprotkb": "Dcun1d5", "gene_names_refseq": "Dcun1d5; RGD1307008", "protein_names_uniprotkb": "DCN1-like protein 5; DCUN1 domain-containing protein 5; Defective in cullin neddylation protein 1-like protein 5; Squamous cell carcinoma-related oncogene 5", "protein_names_refseq": "DCN1, defective in cullin neddylation 1, domain containing 5; DCN1-like protein 5; DCUN1 domain-containing protein 5; defective in cullin neddylation protein 1-like protein 5; squamous cell carcinoma-related oncogene 5", "tax_id": 10116, "disease": "", "pathway": " (rno:315405); (R-RNO-8951664)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032182 ubiquitin-like protein binding;GO:0097602 cullin family protein binding;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005819 spindle;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0001558 regulation of cell growth;GO:0045116 protein neddylation;GO:2000436 positive regulation of protein neddylation;GO:2000434 regulation of protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PPL2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQQ1-1", "uniprot_id": [ { "id": "GTPB3_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQQ1", "type": "external" } ], "mass": 52017.0, "length": 492, "protein_name": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial", "gene_name": "Gtpbp3", "organism": "Rat", "refseq_name": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001011919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011919", "type": "external" } ], "gene_names_uniprotkb": "Gtpbp3", "gene_names_refseq": "Gtpbp3", "protein_names_uniprotkb": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial; 3.6.1.-; GTP-binding protein 3; tRNA modification GTPase GTPBP3, mitochondrial", "protein_names_refseq": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial precursor; 5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial; GTP binding protein 3 (mitochondrial); tRNA modification GTPase GTPBP3, mitochondrial", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency 23 (Disease Ontology:DOID:0111500); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (rno:290633)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "GTPase component of the GTPBP3-MTO1 complex that catalyzes the 5-taurinomethyluridine (taum(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs (mt-tRNAs), which plays a role in mt-tRNA decoding and mitochondrial translation. Taum(5)U formation on mammalian mt-tRNA requires the presence of both GTPBP3-mediated GTPase activity and MTO1 catalytic activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:7770010 GTPBP3-MTO1 complex", "go_biological_process": "GO:0002098 tRNA wobble uridine modification;GO:0030488 tRNA methylation;GO:0070899 mitochondrial tRNA wobble uridine modification;GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PQQ1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQQ8-1", "uniprot_id": [ { "id": "ITGBL_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQQ8", "type": "external" } ], "mass": 53904.0, "length": 494, "protein_name": "Integrin beta-like protein 1", "gene_name": "Itgbl1", "organism": "Rat", "refseq_name": "integrin beta-like protein 1 precursor", "refseq_ac": [ { "id": "NP_001017505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017505", "type": "external" } ], "gene_names_uniprotkb": "Itgbl1", "gene_names_refseq": "Itgbl1", "protein_names_uniprotkb": "Integrin beta-like protein 1", "protein_names_refseq": "integrin beta-like protein 1 precursor; integrin beta-like protein 1; integrin, beta-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:498564)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "37395147", "class_list": "", "function": "Integrin beta-like 1 mediates fibroblast-cardiomyocyte crosstalk to promote cardiac fibrosis and hypertrophy., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0008305 integrin complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0007160 cell-matrix adhesion;GO:0033627 cell adhesion mediated by integrin;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PQQ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PR00-1", "uniprot_id": [ { "id": "DJC22_RAT", "url": "https://www.uniprot.org/uniprot/Q5PR00", "type": "external" } ], "mass": 38243.0, "length": 341, "protein_name": "DnaJ homolog subfamily C member 22", "gene_name": "Dnajc22", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily C member 22", "refseq_ac": [ { "id": "NP_001014226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014226", "type": "external" } ], "gene_names_uniprotkb": "Dnajc22", "gene_names_refseq": "Dnajc22; RGD1311098", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 22", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 22; dnaJ homolog subfamily C member 22", "tax_id": 10116, "disease": "", "pathway": " (rno:362998)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May function as a co-chaperone., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PR00-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJL2-1", "uniprot_id": [ { "id": "MET23_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJL2", "type": "external" } ], "mass": 25277.0, "length": 225, "protein_name": "Histone-arginine methyltransferase METTL23", "gene_name": "Mettl23", "organism": "Rat", "refseq_name": "histone-arginine methyltransferase METTL23", "refseq_ac": [ { "id": "NP_001008284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008284", "type": "external" } ], "gene_names_uniprotkb": "Mettl23", "gene_names_refseq": "Mettl23; RGD1306284", "protein_names_uniprotkb": "Histone-arginine methyltransferase METTL23; 2.1.1.319; Methyltransferase-like protein 23", "protein_names_refseq": "histone-arginine methyltransferase METTL23; methyltransferase like 23; methyltransferase-like protein 23; probable methyltransferase-like protein 23", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 44 (Disease Ontology:DOID:0081208); glaucoma (Disease Ontology:DOID:1686)", "pathway": " (rno:287918)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone methyltransferase that dimethylates histone H3 at 'Arg-17', forming asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. Maternal factor involved in epigenetic chromatin reprogramming of the paternal genome in the zygote: mediates H3R17me2a, promoting histone H3.3 incorporation in the male pronucleus, leading to TET3 recruitment and subsequent DNA demethylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" } ], "go_molecular_function": "GO:0031072 heat shock protein binding;GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity;GO:0035642 histone H3R17 methyltransferase activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0001939 female pronucleus;GO:0001940 male pronucleus;GO:0032991 protein-containing complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050890 cognition;GO:0032259 methylation;GO:0040029 epigenetic regulation of gene expression;GO:0044727 epigenetic programing of male pronucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RJL2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKG5-1", "uniprot_id": [ { "id": "Q5RKG5_RAT", "url": "https://www.uniprot.org/uniprot/Q5RKG5", "type": "external" } ], "mass": 28065.0, "length": 249, "protein_name": "Cilia- and flagella-associated protein 410", "gene_name": "Cfap410", "organism": "Rat", "refseq_name": "cilia and flagella associated protein 410", "refseq_ac": [ { "id": "NP_001008352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008352", "type": "external" } ], "gene_names_uniprotkb": "Cfap410; RGD1309594", "gene_names_refseq": "Cfap410; RGD1309594", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 410", "protein_names_refseq": "cilia and flagella associated protein 410", "tax_id": 10116, "disease": "axial spondylometaphyseal dysplasia (Disease Ontology:DOID:0112299)", "pathway": " (rno:309681)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in cilia formation and/or maintenance. Plays a role in the regulation of cell morphology and cytoskeletal organization. Involved in DNA damage repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0097733 photoreceptor cell cilium;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RKG5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKH0-1", "uniprot_id": [ { "id": "GLYR1_RAT", "url": "https://www.uniprot.org/uniprot/Q5RKH0", "type": "external" } ], "mass": 60421.0, "length": 552, "protein_name": "Cytokine-like nuclear factor N-PAC", "gene_name": "Glyr1", "organism": "Rat", "refseq_name": "cytokine-like nuclear factor N-PAC", "refseq_ac": [ { "id": "NP_001007801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007801", "type": "external" } ], "gene_names_uniprotkb": "Glyr1; Np60", "gene_names_refseq": "3930401k13rik; Glyr1; N-pac; NPAC; RGD1309459", "protein_names_uniprotkb": "Cytokine-like nuclear factor N-PAC; Glyoxylate reductase 1 homolog; NPAC; Nuclear protein NP60; Putative oxidoreductase GLYR1", "protein_names_refseq": "cytokine-like nuclear factor N-PAC; nuclear protein NP60; putative oxidoreductase GLYR1", "tax_id": 10116, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651)", "pathway": " (rno:360477)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression. Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA. Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes. Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300. With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation. Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0051287 NAD binding;GO:0042393 histone binding;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0000786 nucleosome;GO:0005694 chromosome", "go_biological_process": "GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0140673 transcription elongation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RKH0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2R7-1", "uniprot_id": [ { "id": "MESD_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2R7", "type": "external" } ], "mass": 25216.0, "length": 224, "protein_name": "LRP chaperone MESD", "gene_name": "Mesd", "organism": "Rat", "refseq_name": "LRP chaperone MESD precursor", "refseq_ac": [ { "id": "NP_001008346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008346", "type": "external" } ], "gene_names_uniprotkb": "Mesd; Mesdc2", "gene_names_refseq": "Mesdc2; Mesd", "protein_names_uniprotkb": "LRP chaperone MESD; LDLR chaperone MESD; Mesoderm development candidate 2; Mesoderm development protein", "protein_names_refseq": "LDLR chaperone MESD; LRP chaperone MESD precursor; LRP chaperone MESD; mesoderm development candiate 2; mesoderm development candidate 2; mesoderm development protein", "tax_id": 10116, "disease": "osteogenesis imperfecta type 20 (Disease Ontology:DOID:0111849)", "pathway": " (rno:308796)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23481549", "class_list": "", "function": "Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mesd also significantly attenuated hyperoxia-induced pulmonary hypertension (PH) and pulmonary vascular remodeling, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016604 nuclear body", "go_biological_process": "GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0072659 protein localization to plasma membrane;GO:0006909 phagocytosis;GO:0006457 protein folding;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2R7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2X1-1", "uniprot_id": [ { "id": "FBX9_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2X1", "type": "external" } ], "mass": 50689.0, "length": 435, "protein_name": "F-box only protein 9", "gene_name": "Fbxo9", "organism": "Rat", "refseq_name": "F-box only protein 9", "refseq_ac": [ { "id": "NP_001011998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011998", "type": "external" } ], "gene_names_uniprotkb": "Fbxo9", "gene_names_refseq": "Fbxo9", "protein_names_uniprotkb": "F-box only protein 9", "protein_names_refseq": "F-box only protein 9", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:300849); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0045087 innate immune response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0045444 fat cell differentiation;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2X1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U4E6-1", "uniprot_id": [ { "id": "GOGA4_RAT", "url": "https://www.uniprot.org/uniprot/Q5U4E6", "type": "external" } ], "mass": 260191.0, "length": 2259, "protein_name": "Golgin subfamily A member 4", "gene_name": "Golga4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Golga4", "gene_names_refseq": "", "protein_names_uniprotkb": "Golgin subfamily A member 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-6811440)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20966424;22673903", "class_list": "", "function": "Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051020 GTPase binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0043001 Golgi to plasma membrane protein transport;GO:0045773 positive regulation of axon extension;GO:0048193 Golgi vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5U4E6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI14-1", "uniprot_id": [ { "id": "MCMD2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI14", "type": "external" } ], "mass": 76063.0, "length": 681, "protein_name": "Minichromosome maintenance domain-containing protein 2", "gene_name": "Mcmdc2", "organism": "Rat", "refseq_name": "minichromosome maintenance domain-containing protein 2", "refseq_ac": [ { "id": "NP_001019511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019511", "type": "external" } ], "gene_names_uniprotkb": "Mcmdc2", "gene_names_refseq": "Mcmdc2", "protein_names_uniprotkb": "Minichromosome maintenance domain-containing protein 2; MCM domain-containing protein 2", "protein_names_refseq": "MCM domain-containing protein 2; MCM domain-containing protein C8orf45 homolog; minichromosome maintenance domain-containing protein 2; uncharacterized protein C8orf45 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:500392)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an important role in meiotic recombination and associated DNA double-strand break repair., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0042140 late meiotic recombination nodule assembly;GO:0007283 spermatogenesis;GO:0007130 synaptonemal complex assembly;GO:0048477 oogenesis;GO:1990918 double-strand break repair involved in meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI14-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI62-1", "uniprot_id": [ { "id": "MENT_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI62", "type": "external" } ], "mass": 37640.0, "length": 344, "protein_name": "Protein MENT", "gene_name": "C2h1orf56; Ment", "organism": "Rat", "refseq_name": "protein MENT precursor", "refseq_ac": [ { "id": "NP_001007639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007639", "type": "external" } ], "gene_names_uniprotkb": "C2h1orf56; Ment", "gene_names_refseq": "C2h1orf56; MENT; RGD1359334", "protein_names_uniprotkb": "Protein MENT; Methylated in normal thymocytes protein", "protein_names_refseq": "methylated in normal thymocytes protein; protein MENT precursor; protein MENT; uncharacterized protein C1orf56 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:295265)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI62-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIH0-1", "uniprot_id": [ { "id": "MAF1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIH0", "type": "external" } ], "mass": 28922.0, "length": 260, "protein_name": "Repressor of RNA polymerase III transcription MAF1 homolog", "gene_name": "Maf1", "organism": "Rat", "refseq_name": "repressor of RNA polymerase III transcription MAF1 homolog", "refseq_ac": [ { "id": "NP_001014107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014107", "type": "external" } ], "gene_names_uniprotkb": "Maf1", "gene_names_refseq": "Maf1", "protein_names_uniprotkb": "Repressor of RNA polymerase III transcription MAF1 homolog", "protein_names_refseq": "MAF1 homolog, negative regulator of RNA polymerase III; repressor of RNA polymerase III transcription MAF1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:315093); (R-RNO-8943724)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "20417281", "class_list": "", "function": "Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (By similarity). Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB. When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout. Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; We report the characterisation of the proteins Maf1 and Macoco in the brain, which we identify as novel GABAAR beta-subunit interacting proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding;GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding;GO:0050811 GABA receptor binding;GO:0000994 RNA polymerase III core binding;GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016479 negative regulation of transcription by RNA polymerase I;GO:0016480 negative regulation of transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIH0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XII9-1", "uniprot_id": [ { "id": "MFR1L_RAT", "url": "https://www.uniprot.org/uniprot/Q5XII9", "type": "external" } ], "mass": 31730.0, "length": 289, "protein_name": "Mitochondrial fission regulator 1-like", "gene_name": "Mtfr1l", "organism": "Rat", "refseq_name": "mitochondrial fission regulator 1-like isoform a", "refseq_ac": [ { "id": "NP_001013957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013957", "type": "external" } ], "gene_names_uniprotkb": "Mtfr1l; Fam54b", "gene_names_refseq": "Fam54b; Mtfr1l; RGD1305453", "protein_names_uniprotkb": "Mitochondrial fission regulator 1-like", "protein_names_refseq": "family with sequence similarity 54, member B; mitochondrial fission regulator 1-like isoform a; protein FAM54B", "tax_id": 10116, "disease": "", "pathway": " (rno:298549)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Mitochondrial protein required for adaptation of miochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels., [UniProtKB, UniProtKB, UniProtKB]; Mitochondrial protein required for adaptation of mitochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels., [UniProtKB, UniProtKB]; Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0000266 mitochondrial fission;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XII9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99P63-1", "uniprot_id": [ { "id": "MICU2_RAT", "url": "https://www.uniprot.org/uniprot/Q99P63", "type": "external" } ], "mass": 49442.0, "length": 432, "protein_name": "Calcium uptake protein 2, mitochondrial", "gene_name": "Micu2", "organism": "Rat", "refseq_name": "calcium uptake protein 2, mitochondrial", "refseq_ac": [ { "id": "NP_599223", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599223", "type": "external" } ], "gene_names_uniprotkb": "Micu2; 09C01; Efha1; Smhs2", "gene_names_refseq": "Efha1; Micu2; RGD1309934; Smhs2", "protein_names_uniprotkb": "Calcium uptake protein 2, mitochondrial; EF-hand domain-containing family member A1", "protein_names_refseq": "EF hand domain family A1; EF-hand domain family, member A1; EF-hand domain-containing family member A1; calcium uptake protein 2, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:171433); (R-RNO-8949215); (R-RNO-8949664)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11596118;33932586", "class_list": "", "function": "Calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake. At higher calcium levels, calcium-binding to MICU1 and MICU2 induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU2 heterodimer away from the pore, allowing calcium permeation through the MCU channel., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005509 calcium ion binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0034704 calcium channel complex;GO:1990246 uniplex complex", "go_biological_process": "GO:0051562 negative regulation of mitochondrial calcium ion concentration;GO:0071277 cellular response to calcium ion;GO:0006851 mitochondrial calcium ion transmembrane transport;GO:0036444 calcium import into the mitochondrion;GO:0051560 mitochondrial calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99P63-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68LP1-1", "uniprot_id": [ { "id": "MIB2_RAT", "url": "https://www.uniprot.org/uniprot/Q68LP1", "type": "external" } ], "mass": 105542.0, "length": 971, "protein_name": "E3 ubiquitin-protein ligase MIB2", "gene_name": "Mib2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mib2", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MIB2; 2.3.2.27; Mind bomb homolog 2; RBSC-skeletrophin/dystrophin-like polypeptide; RING-type E3 ubiquitin transferase MIB2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-5357786); (R-RNO-5357905); (R-RNO-983168); (R-RNO-9931295)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0098794 postsynapse", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0016567 protein ubiquitination;GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization;GO:0140252 regulation protein catabolic process at postsynapse", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68LP1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P5P5-1", "uniprot_id": [ { "id": "MEST_RAT", "url": "https://www.uniprot.org/uniprot/Q6P5P5", "type": "external" } ], "mass": 38879.0, "length": 335, "protein_name": "Mesoderm-specific transcript homolog protein", "gene_name": "Mest", "organism": "Rat", "refseq_name": "mesoderm-specific transcript homolog protein", "refseq_ac": [ { "id": "NP_001009617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009617", "type": "external" } ], "gene_names_uniprotkb": "Mest", "gene_names_refseq": "Mest", "protein_names_uniprotkb": "Mesoderm-specific transcript homolog protein; 3.-.-.-", "protein_names_refseq": "mesoderm specific transcript homolog; mesoderm-specific transcript homolog protein", "tax_id": 10116, "disease": "Barth syndrome (Disease Ontology:DOID:0050476)", "pathway": " (rno:58827)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "Plays an important role in enabling neurons to transition from bipolar to multipolar shapes, a process essential for their correct migration toward the cortical plate during brain development. This function is likely achieved through the regulation of N-cadherin-dependent cell adhesion and the modulation of Akt and canonical Wnt signaling pathways. Essential for the development and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. Negatively regulates the canonical Wnt signaling pathway during adipogenic differentiation by reducing the glycosylation, maturation, and cell membrane localization of the Wnt coreceptor LRP6., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0032526 response to retinoic acid;GO:0045444 fat cell differentiation;GO:1903077 negative regulation of protein localization to plasma membrane;GO:0010883 regulation of lipid storage", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6P5P5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6Q9-1", "uniprot_id": [ { "id": "MICU1_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6Q9", "type": "external" } ], "mass": 54195.0, "length": 477, "protein_name": "Calcium uptake protein 1, mitochondrial", "gene_name": "Micu1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Micu1; Cbara1", "gene_names_refseq": "", "protein_names_uniprotkb": "Calcium uptake protein 1, mitochondrial; Calcium-binding atopy-related autoantigen 1 homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "myopathy with extrapyramidal signs (Disease Ontology:DOID:0111335); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:365567); (R-RNO-8949215); (R-RNO-8949664)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which senses calcium level via its EF-hand domains. MICU1 and MICU2 (or MICU3) form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake. At higher calcium levels, calcium-binding to MICU1 and MICU2 (or MICU3) induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU2 heterodimer away from the pore, allowing calcium permeation through the MCU channel. Also required to protect against manganese toxicity by preventing manganese uptake by MCU: mechanistically, manganese-binding to its EF-hand domains does not induce any conformational change, maintaining MCU pore occlusion. Acts as a regulator of mitochondrial cristae structure independently of its ability to regulate the mitochondrial calcium uniporter channel. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0005509 calcium ion binding;GO:0019855 calcium channel inhibitor activity;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0031966 mitochondrial membrane;GO:0034704 calcium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0071277 cellular response to calcium ion;GO:0006851 mitochondrial calcium ion transmembrane transport;GO:0036444 calcium import into the mitochondrion;GO:0051560 mitochondrial calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P6Q9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPF2-1", "uniprot_id": [ { "id": "MUC18_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPF2", "type": "external" } ], "mass": 71327.0, "length": 648, "protein_name": "Cell surface glycoprotein MUC18", "gene_name": "Mcam", "organism": "Rat", "refseq_name": "cell surface glycoprotein MUC18 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001029181", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029181", "type": "external" } ], "gene_names_uniprotkb": "Mcam; Muc18", "gene_names_refseq": "CD146; Mcam; Muc18", "protein_names_uniprotkb": "Cell surface glycoprotein MUC18; Gicerin; Melanoma cell adhesion molecule; Melanoma-associated antigen MUC18", "protein_names_refseq": "cell surface glycoprotein MUC18 isoform 2 precursor; cell surface glycoprotein MUC18; gicerin; l-gicerin; melanoma-associated antigen MUC18", "tax_id": 10116, "disease": "malignant mesothelioma (Disease Ontology:DOID:1790); impotence (Disease Ontology:DOID:1875); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); uveal melanoma (Disease Ontology:DOID:6039)", "pathway": " (rno:78967); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013408); (R-RNO-9013423); (R-RNO-9035034)", "pathway_count": 9, "publication_count": 7, "publication_id_list": "14706627;14755543;15880440;29393594;33515199;34477225;34575887", "class_list": "", "function": "CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-alpha4. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of cell adhesion molecule, Gicerin/CD146 during the formation of heart and in the cardiac hypertrophy., [RefSeq, PubMed]; Expression of gicerin was increased in the rat carotid arteries after balloon injury. Gicerin might be involved in the arteriosclerotic neointima formation in the artery., [RefSeq, PubMed]; Increase of gicerin expression by NGF promotes the gicerin-gicerin homophilic interaction resulting in the neurite extension., [RefSeq, PubMed]; Menstrual blood CD146(+) mesenchymal stem cells reduced fibrosis rate in the rat model of premature ovarian failure., [RefSeq, PubMed]; Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6IRH8;Q9ESS8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0043204 perikaryon;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0030335 positive regulation of cell migration;GO:0003094 glomerular filtration;GO:0061042 vascular wound healing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9EPF2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P777-1", "uniprot_id": [ { "id": "MB12A_RAT", "url": "https://www.uniprot.org/uniprot/Q6P777", "type": "external" } ], "mass": 28752.0, "length": 271, "protein_name": "Multivesicular body subunit 12A", "gene_name": "Mvb12a", "organism": "Rat", "refseq_name": "multivesicular body subunit 12A", "refseq_ac": [ { "id": "NP_955407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955407", "type": "external" } ], "gene_names_uniprotkb": "Mvb12a; Fam125a", "gene_names_refseq": "Fam125a; Mvb12a", "protein_names_uniprotkb": "Multivesicular body subunit 12A; ESCRT-I complex subunit MVB12A; Protein FAM125A", "protein_names_refseq": "ESCRT-I complex subunit MVB12A; family with sequence similarity 125, member A; multivesicular body subunit 12A", "tax_id": 10116, "disease": "", "pathway": " (rno:290635); (R-RNO-917729)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0008289 lipid binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0031902 late endosome membrane;GO:0031982 vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0032801 receptor catabolic process;GO:0042058 regulation of epidermal growth factor receptor signaling pathway;GO:0046755 viral budding;GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P777-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY82-1", "uniprot_id": [ { "id": "MUCEN_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY82", "type": "external" } ], "mass": 26516.0, "length": 250, "protein_name": "Endomucin", "gene_name": "Emcn", "organism": "Rat", "refseq_name": "endomucin precursor", "refseq_ac": [ { "id": "NP_001004228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004228", "type": "external" } ], "gene_names_uniprotkb": "Emcn", "gene_names_refseq": "Emcn", "protein_names_uniprotkb": "Endomucin", "protein_names_refseq": "endomucin precursor; sialomucin", "tax_id": 10116, "disease": "thyroid gland carcinoma (Disease Ontology:DOID:3963)", "pathway": " (rno:295490)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0030155 regulation of cell adhesion;GO:0098609 cell-cell adhesion;GO:0061484 hematopoietic stem cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY82-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0H5-1", "uniprot_id": [ { "id": "NCTR1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z0H5", "type": "external" } ], "mass": 37178.0, "length": 325, "protein_name": "Natural cytotoxicity triggering receptor 1", "gene_name": "Fcar; Ncr1", "organism": "Rat", "refseq_name": "natural cytotoxicity triggering receptor 1 precursor", "refseq_ac": [ { "id": "NP_476547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476547", "type": "external" } ], "gene_names_uniprotkb": "Fcar; Ncr1; Ar1; Fcar; Kilr1; Ly94; Ncr1", "gene_names_refseq": "KILR-1; Ly94; Ncr1; Nk-p46; Nkp46", "protein_names_uniprotkb": "Natural cytotoxicity triggering receptor 1; Activating receptor 1; Lymphocyte antigen 94 homolog; NK receptor KILR-1; NK-p46; NKACTR; NKp46; Natural killer cell p46-related protein; rAR-1", "protein_names_refseq": "NK receptor KILR-1; NK-p46); NKACTR; lymphocyte antigen 94 homolog (activating NK-receptor; natural cytotoxicity triggering receptor 1 precursor; natural killer cell p46-related protein; rAR-1; rat-activating receptor 1", "tax_id": 10116, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); lymphoproliferative syndrome (Disease Ontology:DOID:0060704); anogenital venereal wart (Disease Ontology:DOID:11168); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); hepatitis C (Disease Ontology:DOID:1883); IgA glomerulonephritis (Disease Ontology:DOID:2986); acquired immunodeficiency syndrome (Disease Ontology:DOID:635)", "pathway": " (rno:117547)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10424451;15356098", "class_list": "", "function": "Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis., [UniProtKB]; NKp46 activates natural killer cell cytotoxicity by similar pathways as CD16., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0140375 immune receptor activity;GO:0019766 IgA receptor activity;GO:0019862 IgA binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway;GO:0051607 defense response to virus;GO:0009597 detection of virus;GO:0035457 cellular response to interferon-alpha;GO:0038093 Fc receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z0H5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VID1-1", "uniprot_id": [ { "id": "DHRS4_RAT", "url": "https://www.uniprot.org/uniprot/Q8VID1", "type": "external" } ], "mass": 29822.0, "length": 279, "protein_name": "Dehydrogenase/reductase SDR family member 4", "gene_name": "Dhrs4", "organism": "Rat", "refseq_name": "dehydrogenase/reductase SDR family member 4 isoform 1", "refseq_ac": [ { "id": "NP_695227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_695227", "type": "external" } ], "gene_names_uniprotkb": "Dhrs4", "gene_names_refseq": "Dhrs4; PSCD", "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 4; 1.1.1.184; 1.1.1.300; CR; NADPH-dependent carbonyl reductase; NADPH-dependent retinol dehydrogenase/reductase; NDRD; PSCD; Peroxisomal short-chain alcohol dehydrogenase; Protein SDR25C2; Short chain dehydrogenase/reductase family 25C member 2", "protein_names_refseq": "CR; DCR-AKL; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase; NDRD; PHCR; dehydrogenase/reductase (SDR family) member 4; dehydrogenase/reductase SDR family member 4 isoform 1; peroxisomal short-chain alcohol dehydrogenase; short chain dehydrogenase/reductase family 25C member 2", "tax_id": 10116, "disease": "", "pathway": " (rno:266686); (R-RNO-5365859); (R-RNO-9033241)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "23036705;26446791", "class_list": "", "function": "NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Reduces all-trans-retinal and 9-cis retinal. Reduces 3-ketosteroids and benzil into 3alpha-hydroxysteroids and S-benzoin, respectively, in contrast to the stereoselectivity of primates DHRS4s which produce 3beta-hydroxysteroids and R-benzoin. In the reverse reaction, catalyzes the NADP-dependent oxidation of 3alpha-hydroxysteroids and alcohol, but with much lower efficiency. Involved in the metabolism of 3alpha-hydroxysteroids, retinoid, isatin and xenobiotic carbonyl compounds., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; R. norvegicus DHRS2 and DHRS4 genes are syntenic outparalogs that originated from a duplication of the DHRS4 gene that took place before the formation of the mammalian clade. R. norvegicus genes are orthologs of human DHRS2 and DHRS4 genes respectively., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6IRD4", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.122", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.122", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "1.6.5.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.104", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.1.1.189", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.189", "type": "external" }, { "id": "1.1.1.197", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.197", "type": "external" }, { "id": "1.1.1.196", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.196", "type": "external" }, { "id": "1.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.71", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0018455 alcohol dehydrogenase [NAD(P)+] activity;GO:0042802 identical protein binding;GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0042180 ketone metabolic process;GO:0001523 retinoid metabolic process;GO:0006066 alcohol metabolic process;GO:0042574 retinal metabolic process;GO:2000379 positive regulation of reactive oxygen species metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VID1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H12-1", "uniprot_id": [ { "id": "NAGAB_RAT", "url": "https://www.uniprot.org/uniprot/Q66H12", "type": "external" } ], "mass": 46871.0, "length": 415, "protein_name": "Alpha-N-acetylgalactosaminidase", "gene_name": "Naga", "organism": "Rat", "refseq_name": "alpha-N-acetylgalactosaminidase precursor", "refseq_ac": [ { "id": "NP_001012120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012120", "type": "external" } ], "gene_names_uniprotkb": "Naga", "gene_names_refseq": "Naga", "protein_names_uniprotkb": "Alpha-N-acetylgalactosaminidase; 3.2.1.49; Alpha-galactosidase B", "protein_names_refseq": "N-acetyl galactosaminidase, alpha; alpha-N-acetylgalactosaminidase precursor; alpha-galactosidase B", "tax_id": 10116, "disease": "Schindler disease type 1 (Disease Ontology:DOID:0112318); Kanzaki disease (Disease Ontology:DOID:0112319); Fabry disease (Disease Ontology:DOID:14499); neuroaxonal dystrophy (Disease Ontology:DOID:2367); angiokeratoma (Disease Ontology:DOID:479)", "pathway": " (rno:315165)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosylhydrolase", "function": "Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.49", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004557 alpha-galactosidase activity;GO:0008456 alpha-N-acetylgalactosaminidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0019377 glycolipid catabolic process;GO:0016052 carbohydrate catabolic process;GO:0009311 oligosaccharide metabolic process;GO:0016139 glycoside catabolic process;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H12-1", "record_type": "protein", "filter_code": "0000000.1000011.100000.000000000000001000.0000000010001.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FQ2-1", "uniprot_id": [ { "id": "JAM3_RAT", "url": "https://www.uniprot.org/uniprot/Q68FQ2", "type": "external" } ], "mass": 34783.0, "length": 310, "protein_name": "Junctional adhesion molecule C", "gene_name": "Jam3", "organism": "Rat", "refseq_name": "junctional adhesion molecule C precursor", "refseq_ac": [ { "id": "NP_001004269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004269", "type": "external" } ], "gene_names_uniprotkb": "Jam3", "gene_names_refseq": "Jam3", "protein_names_uniprotkb": "Junctional adhesion molecule C; JAM-3; JAM-C; Junctional adhesion molecule 3", "protein_names_refseq": "JAM-3; JAM-C; junctional adhesion molecule C precursor; junctional adhesion molecule C", "tax_id": 10116, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); systemic scleroderma (Disease Ontology:DOID:418)", "pathway": " (rno:315509); (R-RNO-202733); (R-RNO-216083)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "24090084;29393594", "class_list": "", "function": "Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (By similarity). Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (By similarity). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). Plays a role in angiogenesis. Plays a role in the regulation of cell migration (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0043220 Schmidt-Lanterman incisure", "go_biological_process": "GO:0002318 myeloid progenitor cell differentiation;GO:0033624 negative regulation of integrin activation;GO:0097241 hematopoietic stem cell migration to bone marrow;GO:0090138 regulation of actin cytoskeleton organization by cell-cell adhesion;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q68FQ2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHN8-1", "uniprot_id": [ { "id": "MASP1_RAT", "url": "https://www.uniprot.org/uniprot/Q8CHN8", "type": "external" } ], "mass": 80097.0, "length": 704, "protein_name": "Mannan-binding lectin serine protease 1", "gene_name": "Masp1", "organism": "Rat", "refseq_name": "mannan-binding lectin serine protease 1 precursor", "refseq_ac": [ { "id": "NP_071593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071593", "type": "external" } ], "gene_names_uniprotkb": "Masp1; Crarf", "gene_names_refseq": "Masp1/3; Masp1; Masp3", "protein_names_uniprotkb": "Mannan-binding lectin serine protease 1; 3.4.21.-; Complement-activating component of Ra-reactive factor; MASP-1; Mannose-binding lectin-associated serine protease 1; Mannose-binding protein-associated serine protease; Ra-reactive factor serine protease p100; RaRF; Serine protease 5", "protein_names_refseq": "MASP-1; complement factor MASP-3; complement-activating component of Ra-reactive factor; mannan-binding lectin serine peptidase 1; mannan-binding lectin serine protease 1 precursor; mannan-binding lectin serine protease 1; mannan-binding lectin serine protease 2-like; mannose-binding lectin-associated serine protease 1; mannose-binding protein associated serine protease-1; mannose-binding protein-associated serine protease; ra-reactive factor serine protease p100; raRF; serine protease 5; serine protease MASP1", "tax_id": 10116, "disease": "3MC syndrome 1 (Disease Ontology:DOID:0060575)", "pathway": " (rno:64023); (R-RNO-166662); (R-RNO-2855086)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10913141;11337510;12847554;15060079;22078562;28111019;9314946", "class_list": "", "function": "Flexibility in MASP-1 and MASP-2 provides insight on lectin pathway activation., [RefSeq, PubMed]; Precursor of a serum protease that activates the complement pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Serine protease that activates the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The alternative complement pathway acts as an amplification loop that enhances other complement pathways. Isoform MASP-3 specifically catalyzes cleavage and activation of factor D (CFD), the protease that initiates the alternative complement pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Serine protease that activates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The lectin complement system is activated following association of lectins, such as MBL2, FCN1, FCN2 or FCN3, to carbohydrates on the pathogen surface. Following autoproteolytic processing in response to lectin-binding to pathogen carbohydrates, catalyzes cleavage and activation of MASP2, the next component of the lectin complement pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; We present the first structure of such a complex in the form of the collagen-like domain of mannan-binding lectin and the binding domain of its associated protease MASP-1, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O09020;Q5U365;Q8CG41;Q9JJS9", "ec_number_list": [ { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.5.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.16", "type": "external" }, { "id": "3.4.21.104", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.104", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0009986 cell surface;GO:1905370 serine-type endopeptidase complex", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation;GO:0001867 complement activation, lectin pathway;GO:0031638 zymogen activation;GO:0045916 negative regulation of complement activation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CHN8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64349-1", "uniprot_id": [ { "id": "MAL_RAT", "url": "https://www.uniprot.org/uniprot/Q64349", "type": "external" } ], "mass": 16758.0, "length": 153, "protein_name": "Myelin and lymphocyte protein", "gene_name": "Mal", "organism": "Rat", "refseq_name": "myelin and lymphocyte protein", "refseq_ac": [ { "id": "NP_036930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036930", "type": "external" } ], "gene_names_uniprotkb": "Mal; Mvp17", "gene_names_refseq": "MALGENE; Mal", "protein_names_uniprotkb": "Myelin and lymphocyte protein; 17 kDa myelin vesicular protein; MVP17; NS 3; T-lymphocyte maturation-associated protein", "protein_names_refseq": "17 kDa myelin vesicular protein; MVP17; NS 3; T-lymphocyte maturation-associated protein; myelin and lymphocyte protein, T-cell differentiation protein; myelin and lymphocyte protein", "tax_id": 10116, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); metachromatic leukodystrophy (Disease Ontology:DOID:10581)", "pathway": " (rno:25263)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23196718;24878628;25993478;7643216;8583510", "class_list": "", "function": "Data suggest that expression of MAL in cells confers both ETX (Clostridium perfringens epsilon-toxin) binding and susceptibility to ETX-mediated cell death; cells expressing rat MAL are 100 times more sensitive to ETX than cells expressing human MAL. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in vesicular trafficking from the Golgi apparatus to the cell membrane. Plays a role in the maintenance of the myelin sheath, and in axon-glia and glia-glia interactions., [UniProtKB, UniProtKB]; Significant upregulation of MAL in the retinal ganglion cells after optic nerve crush was found., [RefSeq, PubMed]; This is the first description of MAL expression changes in gray matter after spinal cord injury. Our results prompted that MAL might participate in CNS pathophysiology after SCI., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019911 structural constituent of myelin sheath", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0044853 plasma membrane raft;GO:0045121 membrane raft;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0042552 myelination;GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0002175 protein localization to paranode region of axon;GO:0098737 protein insertion into plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q64349-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K3Y6-1", "uniprot_id": [ { "id": "A0A0G2K3Y6_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K3Y6", "type": "external" } ], "mass": 80162.0, "length": 729, "protein_name": "Cytoplasmic polyadenylation element binding protein 4", "gene_name": "Cpeb4", "organism": "Rat", "refseq_name": "cytoplasmic polyadenylation element-binding protein 4 isoform X1", "refseq_ac": [ { "id": "XP_006246040", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006246040", "type": "external" } ], "gene_names_uniprotkb": "Cpeb4", "gene_names_refseq": "Cpeb4", "protein_names_uniprotkb": "Cytoplasmic polyadenylation element binding protein 4", "protein_names_refseq": "cytoplasmic polyadenylation element-binding protein 4 isoform X1", "tax_id": 10116, "disease": "portal hypertension (Disease Ontology:DOID:10762); primary biliary cholangitis (Disease Ontology:DOID:12236); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (rno:303010)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0045182 translation regulator activity;GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003723 RNA binding;GO:0008135 translation factor activity, RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0014069 postsynaptic density;GO:0030425 dendrite", "go_biological_process": "GO:0002931 response to ischemia;GO:0071230 cellular response to amino acid stimulus;GO:2000766 negative regulation of cytoplasmic translation;GO:0036294 cellular response to decreased oxygen levels;GO:0035235 ionotropic glutamate receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2K3Y6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JZC4-1", "uniprot_id": [ { "id": "A0A0G2JZC4_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JZC4", "type": "external" } ], "mass": 119488.0, "length": 1069, "protein_name": "Semaphorin-6D", "gene_name": "Sema6d", "organism": "Rat", "refseq_name": "semaphorin-6D isoform X4", "refseq_ac": [ { "id": "XP_008760394", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008760394", "type": "external" } ], "gene_names_uniprotkb": "Sema6d", "gene_names_refseq": "Sema6d", "protein_names_uniprotkb": "Semaphorin-6D", "protein_names_refseq": "semaphorin-6D isoform X4", "tax_id": 10116, "disease": "", "pathway": " (rno:311384); (R-RNO-416700)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;36156831", "class_list": "", "function": "Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Ligand of TREM2 with PLXNA1 as coreceptor in dendritic cells, plays a role in the generation of immune responses and skeletal homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0045499 chemorepellent activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0G2JZC4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K2W0-1", "uniprot_id": [ { "id": "A0A0G2K2W0_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K2W0", "type": "external" } ], "mass": 251076.0, "length": 2246, "protein_name": "Receptor-type tyrosine-protein phosphatase beta", "gene_name": "Ptprb", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ptprb", "gene_names_refseq": "", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase beta; 3.1.3.48; Vascular endothelial protein tyrosine phosphatase", "protein_names_refseq": "", "tax_id": 10116, "disease": "angiosarcoma (Disease Ontology:DOID:0001816); brain glioma (Disease Ontology:DOID:0060108); colorectal carcinoma (Disease Ontology:DOID:0080199); sarcoma (Disease Ontology:DOID:1115); glioblastoma (Disease Ontology:DOID:3068); osteosarcoma (Disease Ontology:DOID:3347); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); thyroid gland carcinoma (Disease Ontology:DOID:3963); breast angiosarcoma (Disease Ontology:DOID:4511); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:314843); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16641100;29393594", "class_list": "", "function": "Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, 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"https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "1.1.1.-", "url": 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"biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004519 endonuclease activity", "go_cellular_component": "GO:0090730 Las1 complex;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0071339 MLL1 complex;GO:0120330 rixosome complex", "go_biological_process": "GO:0006364 rRNA processing;GO:0000460 maturation of 5.8S rRNA;GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A096MJM8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A096MK39-1", "uniprot_id": [ { "id": "A0A096MK39_RAT", "url": "https://www.uniprot.org/uniprot/A0A096MK39", "type": "external" } ], "mass": 52857.0, "length": 489, "protein_name": "Heat shock transcription factor 4", "gene_name": "Hsf4", "organism": "Rat", "refseq_name": "heat shock factor protein 4 isoform X3", "refseq_ac": [ { "id": "XP_063133975", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063133975", "type": "external" } ], "gene_names_uniprotkb": "Hsf4", "gene_names_refseq": "Hsf4", "protein_names_uniprotkb": "Heat shock transcription factor 4", "protein_names_refseq": "heat shock factor protein 4 isoform X3", "tax_id": 10116, "disease": "cataract 5 multiple types (Disease Ontology:DOID:0110255); neurodegenerative disease (Disease Ontology:DOID:1289); cataract (Disease Ontology:DOID:83)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A096MK39-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K7L6-1", "uniprot_id": [ { "id": "A0A0G2K7L6_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K7L6", "type": "external" } ], "mass": 157769.0, "length": 1412, "protein_name": "FYVE, RhoGEF and PH domain containing 6", "gene_name": "Fgd6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fgd6", "gene_names_refseq": "", "protein_names_uniprotkb": "FYVE, RhoGEF and PH domain containing 6", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:500824)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2K7L6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIS8-1", "uniprot_id": [ { "id": "MID51_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIS8", "type": "external" } ], "mass": 51309.0, "length": 463, "protein_name": "Mitochondrial dynamics protein MID51", "gene_name": "LOC134479940; Mief1", "organism": "Rat", "refseq_name": "mitochondrial dynamics protein MID51", "refseq_ac": [ { "id": "NP_001007710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007710", "type": "external" } ], "gene_names_uniprotkb": "LOC134479940; Mief1; Mid51; Mief1; Smcr7l", "gene_names_refseq": "Mief1; Smcr7l", "protein_names_uniprotkb": "Mitochondrial dynamics protein MID51; Mitochondrial dynamics protein of 51 kDa homolog; Mitochondrial elongation factor 1; Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like", "protein_names_refseq": "Smith-Magenis syndrome chromosome region, candidate 7-like; mitochondrial dynamic protein MID51; mitochondrial dynamic protein of 51 kDa homolog; mitochondrial dynamics protein MID51; mitochondrial dynamics protein of 51 kDa homolog", "tax_id": 10116, "disease": "optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (rno:134479940); (rno:315141); (R-RNO-9937383)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Mitochondrial outer membrane protein which regulates mitochondrial fission/fusion dynamics. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0043531 ADP binding;GO:0019003 GDP binding;GO:0140978 mitochondrial large ribosomal subunit binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0010636 positive regulation of mitochondrial fusion;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0071456 cellular response to hypoxia;GO:0090314 positive regulation of protein targeting to membrane;GO:0000266 mitochondrial fission", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIS8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JVX9-1", "uniprot_id": [ { "id": "A0A0G2JVX9_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JVX9", "type": "external" } ], "mass": 92786.0, "length": 844, "protein_name": "cAMP regulated phosphoprotein 21", "gene_name": "Arpp21", "organism": "Rat", "refseq_name": "cAMP-regulated phosphoprotein 21 isoform X1", "refseq_ac": [ { "id": "XP_006244034", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006244034", "type": "external" } ], "gene_names_uniprotkb": "Arpp21", "gene_names_refseq": "Arpp-21; Arpp21; Ppp1r1cl; Ppp1r1c; RGD1307208; RGD1307215", "protein_names_uniprotkb": "cAMP regulated phosphoprotein 21", "protein_names_refseq": "cAMP-regulated phosphoprotein 21 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:363153)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0030154 cell differentiation;GO:0034605 cellular response to heat;GO:0050852 T cell receptor signaling pathway;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JVX9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4G6-1", "uniprot_id": [ { "id": "MACD1_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4G6", "type": "external" } ], "mass": 28643.0, "length": 258, "protein_name": "ADP-ribose glycohydrolase MACROD1", "gene_name": "Macrod1", "organism": "Rat", "refseq_name": "ADP-ribose glycohydrolase MACROD1", "refseq_ac": [ { "id": "NP_647553", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647553", "type": "external" } ], "gene_names_uniprotkb": "Macrod1; Lrp16", "gene_names_refseq": "Lrp16; Macrod1", "protein_names_uniprotkb": "ADP-ribose glycohydrolase MACROD1; 3.1.1.106; 3.2.2.-; MACRO domain-containing protein 1; O-acetyl-ADP-ribose deacetylase MACROD1; Protein LRP16; [Protein ADP-ribosylaspartate] hydrolase MACROD1; [Protein ADP-ribosylglutamate] hydrolase MACROD1", "protein_names_refseq": "ADP-ribose glycohydrolase MACROD1; MACRO domain containing 1; MACRO domain-containing protein 1; O-acetyl-ADP-ribose deacetylase MACROD1; [Protein ADP-ribosylaspartate] hydrolase MACROD1; [Protein ADP-ribosylglutamate] hydrolase MACROD1; [Protein ADP-ribosylglutamate] hydrolase", "tax_id": 10116, "disease": "", "pathway": " (rno:246233)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" }, { "id": "3.2.2.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.19", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.1.1.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.106", "type": "external" } ], "go_molecular_function": "GO:0019213 deacetylase activity;GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0061463 O-acetyl-ADP-ribose deacetylase activity;GO:0140293 ADP-ribosylglutamate hydrolase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006974 DNA damage response;GO:0051725 protein de-ADP-ribosylation;GO:0042278 purine nucleoside metabolic process;GO:0140291 peptidyl-glutamate ADP-deribosylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8K4G6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K287-1", "uniprot_id": [ { "id": "A0A0G2K287_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K287", "type": "external" } ], "mass": 37753.0, "length": 329, "protein_name": "LIM domain binding 2", "gene_name": "Ldb2", "organism": "Rat", "refseq_name": "LIM domain-binding protein 2 isoform X6", "refseq_ac": [ { "id": "XP_017454600", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017454600", "type": "external" } ], "gene_names_uniprotkb": "Ldb2", "gene_names_refseq": "Ldb2", "protein_names_uniprotkb": "LIM domain binding 2", "protein_names_refseq": "LIM domain-binding protein 2 isoform X6", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0030274 LIM domain binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0031252 cell leading edge;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030334 regulation of cell migration;GO:0001942 hair follicle development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K287-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES02-1", "uniprot_id": [ { "id": "MEPE_RAT", "url": "https://www.uniprot.org/uniprot/Q9ES02", "type": "external" } ], "mass": 46516.0, "length": 435, "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "Mepe", "organism": "Rat", "refseq_name": "matrix extracellular phosphoglycoprotein precursor", "refseq_ac": [ { "id": "NP_077056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077056", "type": "external" } ], "gene_names_uniprotkb": "Mepe", "gene_names_refseq": "Mepe; OF45", "protein_names_uniprotkb": "Matrix extracellular phosphoglycoprotein; OF45; Osteoblast/osteocyte factor 45; Osteoregulin", "protein_names_refseq": "matrix extracellular phosphoglycoprotein precursor; matrix extracellular phosphoglycoprotein with ASARM motif (bone); osteoblast/osteocyte factor 45; osteoregulin", "tax_id": 10116, "disease": "", "pathway": " (rno:79110); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10967096;19005008;19617624;19924383;24255709;27039006", "class_list": "", "function": "Expression of matrix extracellular phosphoglycoprotein (MEPE) in cortical bone of the rat tibia after mechanical loading Publication Status: Online-Only, [RefSeq, PubMed]; Four genes are expressed significantly higher in basal bone than in alveolar bone: SOST, E-11, DMP-1, and MEPE. Three of the proteins (SOST, MEPE, and DMP-1) are associated with mature osteocytes, indicating that basal bone has more mature osteocyte phenotypes because the immature osteocyte converts to a mature osteocyte as a result of bone mineralization., [RefSeq, PubMed]; MEPE expression is bone cell-specific and induced by the BMP-2 signaling pathway, [RefSeq, PubMed]; MEPE is a candidate phosphatonin involved in phosphate homeostasis, acting in both the kidney and the gastrointestinal tract, [RefSeq, PubMed]; Regulates renal phosphate excretion (By similarity). Regulates bone mineralization by osteoblasts and cartilage mineralization by chondrocytes (By similarity). Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Increases dental pulp stem cell proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2K7K7;D6C6P2;Q8K3V0", "ec_number_list": [], "go_molecular_function": "GO:1990430 extracellular matrix protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0031214 biomineral tissue development;GO:0030502 negative regulation of bone mineralization;GO:0046850 regulation of bone remodeling", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ES02-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JYF7-1", "uniprot_id": [ { "id": "A0A0G2JYF7_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JYF7", "type": "external" } ], "mass": 105286.0, "length": 953, "protein_name": "Catenin alpha-2", "gene_name": "Ctnna2", "organism": "Rat", "refseq_name": "catenin alpha-2 isoform 1", "refseq_ac": [ { "id": "NP_001100068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100068", "type": "external" } ], "gene_names_uniprotkb": "Ctnna2", "gene_names_refseq": "Catna2; Ctnna2", "protein_names_uniprotkb": "Catenin alpha-2; Alpha N-catenin", "protein_names_refseq": "catenin (cadherin associated protein), alpha 2; catenin alpha-2 isoform 1", "tax_id": 10116, "disease": "complex cortical dysplasia with other brain malformations 9 (Disease Ontology:DOID:0061138)", "pathway": " (rno:297357); (R-RNO-525793)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16641100;22673903;38843836", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0005198 structural molecule activity;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0015629 actin cytoskeleton;GO:0030424 axon", "go_biological_process": "GO:0007155 cell adhesion;GO:0030154 cell differentiation;GO:0016477 cell migration;GO:0098609 cell-cell adhesion;GO:0098885 modification of postsynaptic actin cytoskeleton", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A0G2JYF7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K1F2-1", "uniprot_id": [ { "id": "A0A0G2K1F2_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K1F2", "type": "external" } ], "mass": 279514.0, "length": 2483, "protein_name": "acetyl-CoA carboxylase", "gene_name": "Acacb", "organism": "Rat", "refseq_name": "acetyl-CoA carboxylase 2 isoform X1", "refseq_ac": [ { "id": "XP_017453731", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017453731", "type": "external" } ], "gene_names_uniprotkb": "Acacb", "gene_names_refseq": "Acacb; Acc2", "protein_names_uniprotkb": "acetyl-CoA carboxylase; 6.4.1.2", "protein_names_refseq": "acetyl-CoA carboxylase 2 isoform X1", "tax_id": 10116, "disease": "chromosome 17q12 deletion syndrome (Disease Ontology:DOID:0060404); muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-RNO-196780); (R-RNO-200425)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16396499;22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.4.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003989 acetyl-CoA carboxylase activity;GO:0042802 identical protein binding;GO:0009374 biotin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0016507 mitochondrial fatty acid beta-oxidation multienzyme complex", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:2001295 malonyl-CoA biosynthetic process;GO:0007584 response to nutrient;GO:0046322 negative regulation of fatty acid oxidation;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0G2K1F2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62625-1", "uniprot_id": [ { "id": "MLP3B_RAT", "url": "https://www.uniprot.org/uniprot/Q62625", "type": "external" } ], "mass": 16394.0, "length": 142, "protein_name": "Microtubule-associated protein 1 light chain 3 beta", "gene_name": "Map1lc3b", "organism": "Rat", "refseq_name": "microtubule-associated protein 1 light chain 3 beta", "refseq_ac": [ { "id": "NP_074058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_074058", "type": "external" } ], "gene_names_uniprotkb": "Map1lc3b; Map1alc3; Map1lc3b2; Map1lc3", "gene_names_refseq": "LC3B; Map1lc3b; Map1lc3; Mpl3; zbs559", "protein_names_uniprotkb": "Microtubule-associated protein 1 light chain 3 beta; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B LC3 B; MAP1A/MAP1B light chain 3 B; Microtubule-associated proteins 1A/1B light chain 3B", "protein_names_refseq": "MAP1 light chain 3-like protein 2; MAP1A/1B light chain 3 B; MAP1A/MAP1B LC3 B; MAP1A/MAP1B light chain 3 B; autophagy-related protein LC3 B; autophagy-related ubiquitin-like modifier LC3 B; microtubule-associated protein 1 light chain 3 beta; microtubule-associated proteins 1A/1B light chain 3B", "tax_id": 10116, "disease": "", "pathway": " (rno:64862); (R-RNO-1632852); (R-RNO-5205685); (R-RNO-8854214); (R-RNO-8934903); (R-RNO-9664873); (R-RNO-9755511)", "pathway_count": 7, "publication_count": 12, "publication_id_list": "11060023;15095872;15265004;15325588;16183633;16874114;19322194;23399561;31140414;33391467;38651895;7908909", "class_list": "", "function": "A thermosensitive, reactive oxygen species-responsive, MR409-encapsulated hydrogel ameliorates disc degeneration in rats by inhibiting the secretory autophagy pathway. Erratum:[Theranostics. 2024 Sep 12;14(15):5982-5983. doi: 10.7150/thno.103020. PMID: 39346549] Publication Status: Online-Only, [RefSeq, PubMed]; Data show that caldendrin specifically associates with the microtubule cytoskeleton via an interaction with the microtubule componentlight chain 3 (Mpl3)., [RefSeq, PubMed]; Exosomal MALAT1 from macrophages treated with high levels of glucose upregulates LC3B expression via miR-204-5p downregulation., [RefSeq, PubMed]; Mitochondrial ALDH2 inhibits the proliferation of neonatal rat cardiac fibroblasts induced by high glucose, and the effect is possibly mediated by the up-regulation of autophagy-related proteins Beclin-1 and LC3B., [RefSeq, PubMed]; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. Upon nutrient stress, directly recruits cofactor JMY to the phagophore membrane surfaces and promotes JMY's actin nucleation activity and autophagosome biogenesis during autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6XVN7", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019904 protein domain specific binding;GO:0031625 ubiquitin protein ligase binding;GO:0008429 phosphatidylethanolamine binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005739 mitochondrion;GO:0005874 microtubule;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0016236 macroautophagy;GO:0006914 autophagy;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q62625-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JW02-1", "uniprot_id": [ { "id": "A0A0G2JW02_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JW02", "type": "external" } ], "mass": 61699.0, "length": 541, "protein_name": "glucuronosyltransferase", "gene_name": "Ugt2a3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ugt2a3", "gene_names_refseq": "", "protein_names_uniprotkb": "glucuronosyltransferase; 2.4.1.17", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:289533); (R-RNO-156588); (R-RNO-9749641)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" } ], "go_molecular_function": "GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JW02-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JYB9-1", "uniprot_id": [ { "id": "A0A0G2JYB9_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JYB9", "type": "external" } ], "mass": 86273.0, "length": 773, "protein_name": "C-Maf-inducing protein", "gene_name": "Cmip", "organism": "Rat", "refseq_name": "C-Maf-inducing protein", "refseq_ac": [ { "id": "NP_001156745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156745", "type": "external" } ], "gene_names_uniprotkb": "Cmip", "gene_names_refseq": "Cmip; RGD1306101; c-Mip", "protein_names_uniprotkb": "C-Maf-inducing protein", "protein_names_refseq": "C-Maf-inducing protein", "tax_id": 10116, "disease": "", "pathway": " (rno:292051)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "28791377", "class_list": "", "function": "CMIP inhibits cofilin1 activity and alters podocyte cytoskeleton organization at least through RhoA signaling in PAinduced podocyte injury, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JYB9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JV35-1", "uniprot_id": [ { "id": "A0A0G2JV35_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JV35", "type": "external" } ], "mass": 34222.0, "length": 312, "protein_name": "N-alpha-acetyltransferase 80", "gene_name": "Naa80", "organism": "Rat", "refseq_name": "N-alpha-acetyltransferase 80", "refseq_ac": [ { "id": "NP_001291705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291705", "type": "external" } ], "gene_names_uniprotkb": "Naa80", "gene_names_refseq": "Naa80; Nat6", "protein_names_uniprotkb": "N-alpha-acetyltransferase 80; N-acetyltransferase 6", "protein_names_refseq": "N-acetyltransferase 6 (GCN5-related); N-acetyltransferase 6-like; N-alpha-acetyltransferase 80", "tax_id": 10116, "disease": "", "pathway": " (rno:100910872)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation. In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu. In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp. May act as a tumor suppressor., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008080 N-acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:1905502 acetyl-CoA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008064 regulation of actin polymerization or depolymerization;GO:0006473 protein acetylation;GO:0030047 actin modification;GO:0018002 N-terminal peptidyl-glutamic acid acetylation;GO:0017190 N-terminal peptidyl-aspartic acid acetylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JV35-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K6G1-1", "uniprot_id": [ { "id": "A0A0G2K6G1_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K6G1", "type": "external" } ], "mass": 28701.0, "length": 261, "protein_name": "tissue kallikrein", "gene_name": "Klk1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Klk1", "gene_names_refseq": "", "protein_names_uniprotkb": "tissue kallikrein; 3.4.21.35", "protein_names_refseq": "", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); breast cancer (Disease Ontology:DOID:1612); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (rno:24523)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0045177 apical part of cell;GO:0001669 acrosomal vesicle;GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0006508 proteolysis;GO:0007584 response to nutrient;GO:0008284 positive regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0002675 positive regulation of acute inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K6G1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JWT8-1", "uniprot_id": [ { "id": "A0A0G2JWT8_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JWT8", "type": "external" } ], "mass": 37242.0, "length": 335, "protein_name": "Olfactory receptor", "gene_name": "Or14a257b; Or14a257c; Or14a257", "organism": "Rat", "refseq_name": "olfactory receptor Olr29", "refseq_ac": [ { "id": "NP_001000691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000691", "type": "external" } ], "gene_names_uniprotkb": "Or14a257b; Or14a257c; Or14a257; Olr29; Or14a257c; Or14a257", "gene_names_refseq": "Olr29; Or14a257b", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 29; olfactory receptor Olr29; olfactory receptor gene Olr29", "tax_id": 10116, "disease": "", "pathway": " (rno:404895); (rno:404896); (rno:405258)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JWT8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JW57-1", "uniprot_id": [ { "id": "A0A0G2JW57_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JW57", "type": "external" } ], "mass": 64590.0, "length": 566, "protein_name": "Kelch-like family member 23", "gene_name": "Klhl23", "organism": "Rat", "refseq_name": "kelch-like protein 23 isoform X1", "refseq_ac": [ { "id": "XP_006234375", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006234375", "type": "external" } ], "gene_names_uniprotkb": "Klhl23", "gene_names_refseq": "Klhl23; RGD1307166", "protein_names_uniprotkb": "Kelch-like family member 23", "protein_names_refseq": "kelch-like protein 23 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:311114)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JW57-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JUY5-1", "uniprot_id": [ { "id": "A0A0G2JUY5_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JUY5", "type": "external" } ], "mass": 67547.0, "length": 629, "protein_name": "Coiled-coil domain containing 120", "gene_name": "Ccdc120", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ccdc120", "gene_names_refseq": "", "protein_names_uniprotkb": "Coiled-coil domain containing 120", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:317377)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005814 centriole;GO:0120103 centriolar subdistal appendage", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0034454 microtubule anchoring at centrosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JUY5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K3G6-1", "uniprot_id": [ { "id": "A0A0G2K3G6_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K3G6", "type": "external" } ], "mass": 72524.0, "length": 641, "protein_name": "Regulatory factor X4", "gene_name": "Rfx4", "organism": "Rat", "refseq_name": "transcription factor RFX4 isoform X9", "refseq_ac": [ { "id": "XP_006241245", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006241245", "type": "external" } ], "gene_names_uniprotkb": "Rfx4", "gene_names_refseq": "Rfx4", "protein_names_uniprotkb": "Regulatory factor X4", "protein_names_refseq": "transcription factor RFX4 isoform X9", "tax_id": 10116, "disease": "", "pathway": " (rno:500818)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor that plays a role in early brain development. May activate transcription by interacting directly with the X-box. May activate transcription from CX3CL1 promoter through the X-box during brain development. May be required for neural tube ciliogenesis during embryogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003682 chromatin binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0021696 cerebellar cortex morphogenesis;GO:0021516 dorsal spinal cord development;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K3G6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JV12-1", "uniprot_id": [ { "id": "A0A0G2JV12_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JV12", "type": "external" } ], "mass": 138969.0, "length": 1352, "protein_name": "Collagen alpha-1(XV) chain", "gene_name": "Col15a1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Col15a1; LOC100909752", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-1(XV) chain", "protein_names_refseq": "", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); dilated cardiomyopathy (Disease Ontology:DOID:12930); myopathy (Disease Ontology:DOID:423); mitochondrial myopathy (Disease Ontology:DOID:699)", "pathway": " (rno:298069); (R-RNO-1442490); (R-RNO-1650814); (R-RNO-2022090); (R-RNO-8948216)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "16641100", "class_list": "", "function": "Restin potently inhibits angiogenesis., [UniProtKB, UniProtKB, UniProtKB]; Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005604 basement membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JV12-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62635-1", "uniprot_id": [ { "id": "MUC2_RAT", "url": "https://www.uniprot.org/uniprot/Q62635", "type": "external" } ], "mass": 166038.0, "length": 1513, "protein_name": "Mucin-2", "gene_name": "Muc2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Muc2", "gene_names_refseq": "", "protein_names_uniprotkb": "Mucin-2; Intestinal mucin-2; MUC-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); pre-malignant neoplasm (Disease Ontology:DOID:0060071); colitis (Disease Ontology:DOID:0060180); mucositis (Disease Ontology:DOID:0080178); pre-eclampsia (Disease Ontology:DOID:10591); allergic conjunctivitis (Disease Ontology:DOID:11204); primary biliary cholangitis (Disease Ontology:DOID:12236); cystic fibrosis (Disease Ontology:DOID:1485); breast cancer (Disease Ontology:DOID:1612); cystitis (Disease Ontology:DOID:1679); colon cancer (Disease Ontology:DOID:219); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometriosis (Disease Ontology:DOID:289); breast ductal carcinoma (Disease Ontology:DOID:3007); invasive ductal carcinoma (Disease Ontology:DOID:3008); mucinous adenocarcinoma (Disease Ontology:DOID:3030); ischemia (Disease Ontology:DOID:326); uterine cancer (Disease Ontology:DOID:363); cervical cancer (Disease Ontology:DOID:4362); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); intestinal disease (Disease Ontology:DOID:5295); pneumonia (Disease Ontology:DOID:552); ulcerative colitis (Disease Ontology:DOID:8577); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); Barrett's esophagus (Disease Ontology:DOID:9206)", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "8027037;8360170;8910009;9341141;9512496", "class_list": "", "function": "Coats the epithelia of the intestines and other mucus membrane-containing organs to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of the colon mucus, which is mainly formed by large polymeric networks of MUC2 secreted by goblet cells that cover the exposed surfaces of intestine. MUC2 networks form hydrogels that guard the underlying epithelium from pathogens and other hazardous matter entering from the outside world, while permitting nutrient absorption and gas exchange. Acts as a divalent copper chaperone that protects intestinal cells from copper toxicity and facilitates nutritional copper unptake into cells. Binds both Cu(2+) and its reduced form, Cu(1+), at two juxtaposed binding sites: Cu(2+), once reduced to Cu(1+) by vitamin C (ascorbate) or other dietary antioxidants, transits to the other binding site. MUC2-bound Cu(1+) is protected from oxidation in aerobic environments, and can be released for nutritional delivery to cells. Mucin gels store antimicrobial molecules that participate in innate immunity. Mucin glycoproteins also house and feed the microbiome, lubricate tissue surfaces, and may facilitate the removal of contaminants and waste products from the body (By similarity). Goblet cells synthesize two forms of MUC2 mucin that differ in branched chain O-glycosylation and the site of production in the colon: a (1) 'thick' mucus that wraps the microbiota to form fecal pellets is produced in the proximal, ascending colon. 'Thick' mucus transits along the descending colon and is lubricated by a (2) 'thin' MUC2 mucus produced in the distal colon which adheres to the 'thick' mucus (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 27, "predicted_n_glycosites": 12, "predicted_o_glycosites": 15, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 71, "disease_count": 28, "glyco_site_count": 27, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:1903136 cuprous ion binding;GO:1903135 cupric ion binding;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0070701 mucus layer;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0070702 inner mucus layer;GO:0070703 outer mucus layer", "go_biological_process": "GO:0071559 response to transforming growth factor beta;GO:0008285 negative regulation of cell population proliferation;GO:0032496 response to lipopolysaccharide;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 7.8, "record_id": "Q62635-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000001000.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIG2-1", "uniprot_id": [ { "id": "MARF1_RAT", "url": "https://www.uniprot.org/uniprot/Q8VIG2", "type": "external" } ], "mass": 192642.0, "length": 1735, "protein_name": "Meiosis regulator and mRNA stability factor 1", "gene_name": "Marf1", "organism": "Rat", "refseq_name": "meiosis regulator and mRNA stability factor 1", "refseq_ac": [ { "id": "NP_596912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596912", "type": "external" } ], "gene_names_uniprotkb": "Marf1; Lkap", "gene_names_refseq": "Lkap; Marf1", "protein_names_uniprotkb": "Meiosis regulator and mRNA stability factor 1; Limkain-b1; Meiosis arrest female protein 1", "protein_names_refseq": "limkain-b1; meiosis arrest female 1; meiosis arrest female protein 1-like; meiosis arrest female protein 1; meiosis regulator and mRNA stability factor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:170946)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1LNE9", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0004540 RNA nuclease activity;GO:1905762 CCR4-NOT complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome", "go_biological_process": "GO:0006302 double-strand break repair;GO:0007143 female meiotic nuclear division;GO:0010468 regulation of gene expression;GO:0048477 oogenesis;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VIG2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64204-1", "uniprot_id": [ { "id": "DLX2_RAT", "url": "https://www.uniprot.org/uniprot/Q64204", "type": "external" } ], "mass": 8700.0, "length": 83, "protein_name": "Homeobox protein DLX-2", "gene_name": "Dlx2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dlx2", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein DLX-2; DLX-5", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:296499)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8613727", "class_list": "", "function": "Acts as a transcriptional activator (By similarity). Activates transcription of CGA/alpha-GSU, via binding to the downstream activin regulatory element (DARE) in the gene promoter (By similarity). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity). Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0003727 single-stranded RNA binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021879 forebrain neuron differentiation;GO:0046533 negative regulation of photoreceptor cell differentiation;GO:0021544 subpallium development;GO:0021893 cerebral cortex GABAergic interneuron fate commitment;GO:0048755 branching morphogenesis of a nerve", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q64204-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QX82-1", "uniprot_id": [ { "id": "MUC24_RAT", "url": "https://www.uniprot.org/uniprot/Q9QX82", "type": "external" } ], "mass": 20476.0, "length": 195, "protein_name": "Sialomucin core protein 24", "gene_name": "Cd164", "organism": "Rat", "refseq_name": "sialomucin core protein 24 precursor", "refseq_ac": [ { "id": "NP_114000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114000", "type": "external" } ], "gene_names_uniprotkb": "Cd164", "gene_names_refseq": "Cd164; MGC-24v", "protein_names_uniprotkb": "Sialomucin core protein 24; Endolyn; MGC-24v; MGC-24; MUC-24; Multi-glycosylated core protein 24", "protein_names_refseq": "CD164 antigen; CD164 molecule, sialomucin; MGC-24; MUC-24; endolyn; multi-glycosylated core protein 24; sialomucin core protein 24 precursor; sialomucin core protein 24", "tax_id": 10116, "disease": "autosomal dominant nonsyndromic deafness 66 (Disease Ontology:DOID:0110587)", "pathway": " (rno:83689)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10620506;14699065;22855528", "class_list": "", "function": "Data indicate that galectin-9 plays a role in apical sorting of endolyn. Erratum:[Mol Biol Cell. 2012 Oct;23(20):4142], [RefSeq, PubMed]; Sialomucin that may play a key role in hematopoiesis. May be involved in cell adhesion. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity)., [UniProtKB, UniProtKB]; Specific N-glycans are only essential for the apical sorting of transmembrane endolyn, suggesting fundamental differences in the mechanisms by which soluble, glycosylphosphatidylinositol-anchored, and transmembrane proteins are sorted., [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 8, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007517 muscle organ development;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QX82-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESY6-1", "uniprot_id": [ { "id": "LRRN3_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESY6", "type": "external" } ], "mass": 79064.0, "length": 707, "protein_name": "Leucine-rich repeat neuronal protein 3", "gene_name": "Lrrn3", "organism": "Rat", "refseq_name": "leucine-rich repeat neuronal protein 3 precursor", "refseq_ac": [ { "id": "NP_110483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110483", "type": "external" } ], "gene_names_uniprotkb": "Lrrn3; Nlrr3", "gene_names_refseq": "Lrrn3; Nlrr3", "protein_names_uniprotkb": "Leucine-rich repeat neuronal protein 3; NLRR-3; Neuronal leucine-rich repeat protein 3", "protein_names_refseq": "NLRR-3; leucine rich repeat protein 3, neuronal; leucine-rich repeat neuronal protein 3 precursor; leucine-rich repeat neuronal protein 3; neuronal leucine-rich repeat protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:81514)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11549284;12297494;21685698", "class_list": "", "function": "LRRN3 plays an important role in postnatal cerebellum development., [RefSeq, PubMed]; NLRR-3 potentiates Ras-MAPK signaling by facilitating internalization of EGF in clathrin-coated vesicles, [RefSeq, PubMed]; RNLRR-3 gene expression is regulated mainly through the Ras-MAPK signaling pathway in fibroblasts, [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q642E4", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030131 clathrin adaptor complex;GO:0016020 membrane", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9ESY6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HR2-1", "uniprot_id": [ { "id": "MARE1_RAT", "url": "https://www.uniprot.org/uniprot/Q66HR2", "type": "external" } ], "mass": 30004.0, "length": 268, "protein_name": "Microtubule-associated protein RP/EB family member 1", "gene_name": "Mapre1", "organism": "Rat", "refseq_name": "microtubule-associated protein RP/EB family member 1", "refseq_ac": [ { "id": "NP_612518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612518", "type": "external" } ], "gene_names_uniprotkb": "Mapre1", "gene_names_refseq": "Eb1; Mapre1", "protein_names_uniprotkb": "Microtubule-associated protein RP/EB family member 1; APC-binding protein EB1; EB1; End-binding protein 1", "protein_names_refseq": "APC-binding protein EB1; adenomatosis polyposis coli binding protein Eb1; end-binding protein 1; microtubule-associated protein RP/EB family member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:114764); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-5663220); (R-RNO-68877); (R-RNO-8852276); (R-RNO-8854518); (R-RNO-9648025)", "pathway_count": 16, "publication_count": 5, "publication_id_list": "11831388;19553473;21357749;25225338;31909540", "class_list": "", "function": "In this study we used EB1 immunostaining in mitotic NRK-52E cells to quantitatively analyse the length and number of growing astral microtubules during metaphase and anaphase, [RefSeq, PubMed]; NC1-peptide regulates spermatogenesis through changes in cytoskeletal organization mediated by EB1., [RefSeq, PubMed]; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains. Promotes cytoplasmic microtubule nucleation and elongation. Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation. Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (By similarity). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (By similarity). Promotes microtubule-mediated GJA1/CX43 trafficking to cell membranes via its interaction with DSP, thereby facilitating gap junction intracellular communication (PubMed:25225338). May play a role in cell migration (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051010 microtubule plus-end binding;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0030981 cortical microtubule cytoskeleton;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0046785 microtubule polymerization;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0016477 cell migration;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q66HR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER33-1", "uniprot_id": [ { "id": "CNGA3_RAT", "url": "https://www.uniprot.org/uniprot/Q9ER33", "type": "external" } ], "mass": 76420.0, "length": 670, "protein_name": "Cyclic nucleotide-gated channel alpha-3", "gene_name": "Cnga3", "organism": "Rat", "refseq_name": "cyclic nucleotide-gated channel alpha-3 isoform 1", "refseq_ac": [ { "id": "NP_001385615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385615", "type": "external" } ], "gene_names_uniprotkb": "Cnga3", "gene_names_refseq": "CNG-3; CNG3; CNGgust; Cnga3", "protein_names_uniprotkb": "Cyclic nucleotide-gated channel alpha-3; CNG channel alpha-3; CNG-3; CNG3; CNGgust; Cone photoreceptor cGMP-gated channel subunit alpha-3; Gustatory cyclic nucleotide-gated cation channel", "protein_names_refseq": "CNG channel alpha-3; cone photoreceptor cGMP-gated channel subunit alpha-3; cyclic nucleotide gated channel alpha 3; cyclic nucleotide-gated cation channel alpha-3; cyclic nucleotide-gated channel alpha-3 isoform 1; gustatory cyclic nucleotide-gated cation channel", "tax_id": 10116, "disease": "achromatopsia 2 (Disease Ontology:DOID:0110007); color blindness (Disease Ontology:DOID:13399)", "pathway": " (rno:85257)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11387380;11764791;15178415;22248097;23329832;9278419", "class_list": "", "function": "Data indicate that CNGA3 interacts with cadherin 23 and with cadherin 23 binding partner, myosin VIIa., [RefSeq, PubMed]; Pore-forming subunit of the cone cyclic nucleotide-gated channel. Mediates cone photoresponses at bright light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations., [UniProtKB, UniProtKB, UniProtKB]; Pore-forming subunit of the gustatory cyclic nucleotide-gated channel. In the taste buds, may sense oral extracellular pH and conduct ion currents that modulate the excitability of taste cells., [UniProtKB, PubMed, PubMed, PubMed]; Pull-down assays indicated that the binding to organ of Corti CNGA3 was attributable to the EMILIN1 intracellular sequence that follows a predicted transmembrane domain in the C-terminus, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QWN7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0045296 cadherin binding;GO:0017022 myosin binding;GO:0005223 intracellularly cGMP-activated cation channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity;GO:0030553 cGMP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0043194 axon initial segment", "go_biological_process": "GO:0034220 monoatomic ion transmembrane transport;GO:0051899 membrane depolarization;GO:0060041 retina development in camera-type eye;GO:0098655 monoatomic cation transmembrane transport;GO:0006812 monoatomic cation transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ER33-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIN3-1", "uniprot_id": [ { "id": "MIPT3_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIN3", "type": "external" } ], "mass": 74114.0, "length": 653, "protein_name": "TRAF3-interacting protein 1", "gene_name": "Traf3ip1", "organism": "Rat", "refseq_name": "TRAF3-interacting protein 1", "refseq_ac": [ { "id": "NP_001012204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012204", "type": "external" } ], "gene_names_uniprotkb": "Traf3ip1; Ift54; Mipt3", "gene_names_refseq": "Ift54; MIP-T3; Traf3ip1", "protein_names_uniprotkb": "TRAF3-interacting protein 1; Intraflagellar transport protein 54 homolog; MIP-T3; Microtubule-interacting protein associated with TRAF3", "protein_names_refseq": "TNF receptor-associated factor 3 interacting protein 1; TRAF3 interacting protein 1; TRAF3-interacting protein 1; intraflagellar transport protein 54 homolog; microtubule-interacting protein associated with TRAF3", "tax_id": 10116, "disease": "Senior-Loken syndrome (Disease Ontology:DOID:0050576); nephronophthisis (Disease Ontology:DOID:12712)", "pathway": " (rno:363286); (R-RNO-5620924)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules (By similarity). Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0005930 axoneme;GO:0036064 ciliary basal body;GO:0097546 ciliary base", "go_biological_process": "GO:0001822 kidney development;GO:0001933 negative regulation of protein phosphorylation;GO:0031076 embryonic camera-type eye development;GO:0060271 cilium assembly;GO:0031333 negative regulation of protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIN3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZV2-1", "uniprot_id": [ { "id": "DCBD2_RAT", "url": "https://www.uniprot.org/uniprot/Q91ZV2", "type": "external" } ], "mass": 83915.0, "length": 769, "protein_name": "Discoidin, CUB and LCCL domain-containing protein 2", "gene_name": "Dcbld2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dcbld2; Esdn", "gene_names_refseq": "", "protein_names_uniprotkb": "Discoidin, CUB and LCCL domain-containing protein 2; Endothelial and smooth muscle cell-derived neuropilin-like protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:155696)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11447234", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0030308 negative regulation of cell growth;GO:0042060 wound healing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91ZV2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ25-1", "uniprot_id": [ { "id": "MEFV_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJ25", "type": "external" } ], "mass": 83743.0, "length": 747, "protein_name": "Pyrin", "gene_name": "Mefv", "organism": "Rat", "refseq_name": "pyrin", "refseq_ac": [ { "id": "NP_113822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113822", "type": "external" } ], "gene_names_uniprotkb": "Mefv", "gene_names_refseq": "Mefv; pyrin", "protein_names_uniprotkb": "Pyrin", "protein_names_refseq": "MEFV innate immuity regulator, pyrin; MEFV, pyrin innate immunity regulator; Mediterranean fever; marenostrin; pyrin", "tax_id": 10116, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); Sweet syndrome (Disease Ontology:DOID:0080746); IgA vasculitis (Disease Ontology:DOID:11123); asthma (Disease Ontology:DOID:2841); familial Mediterranean fever (Disease Ontology:DOID:2987); lung disease (Disease Ontology:DOID:850); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:58923); (R-RNO-844456)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10818206", "class_list": "", "function": "Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation. However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (By similarity). Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (By similarity). It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2JYG3", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:0034021 response to silicon dioxide;GO:0032651 regulation of interleukin-1 beta production;GO:0006954 inflammatory response;GO:0032496 response to lipopolysaccharide;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JJ25-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IG03-1", "uniprot_id": [ { "id": "K2C73_RAT", "url": "https://www.uniprot.org/uniprot/Q6IG03", "type": "external" } ], "mass": 60387.0, "length": 553, "protein_name": "Keratin, type II cytoskeletal 73", "gene_name": "Krt73", "organism": "Rat", "refseq_name": "keratin, type II cytoskeletal 73", "refseq_ac": [ { "id": "NP_001008808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008808", "type": "external" } ], "gene_names_uniprotkb": "Krt73; Kb36", "gene_names_refseq": "CK-73; K73; Kb36; Krt73", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 73; CK-73; Cytokeratin-73; K73; Keratin-73; Type II inner root sheath-specific keratin-K6irs3; Type-II keratin Kb36", "protein_names_refseq": "cytokeratin-73; keratin 73, type II; keratin, type II cytoskeletal 73; type II inner root sheath-specific keratin-K6irs3; type II keratin-36; type-II keratin Kb36", "tax_id": 10116, "disease": "", "pathway": " (rno:300248); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15085952;38843836", "class_list": "", "function": "Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6IG03-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FS3-1", "uniprot_id": [ { "id": "FBX7_RAT", "url": "https://www.uniprot.org/uniprot/Q68FS3", "type": "external" } ], "mass": 57561.0, "length": 522, "protein_name": "F-box only protein 7", "gene_name": "Fbxo7", "organism": "Rat", "refseq_name": "F-box only protein 7", "refseq_ac": [ { "id": "NP_001012222", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012222", "type": "external" } ], "gene_names_uniprotkb": "Fbxo7", "gene_names_refseq": "Fbxo7", "protein_names_uniprotkb": "F-box only protein 7", "protein_names_refseq": "F-box only protein 7", "tax_id": 10116, "disease": "Parkinson's disease 15 (Disease Ontology:DOID:0060372); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:366854); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Recognizes and ubiquitinates BIRC2 and the cell cycle regulator DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. Mediates the ubiquitination and proteasomal degradation of UXT isoform 2, thereby impairing the NF-kappa-B signaling pathway. Inhibits NF-kappa-B pathway also by promoting the ubiquitinatioin of TRAF2 (By similarity). Affects the assembly state and activity of the proteasome in the cells including neurons by ubiquitinating the proteasomal subunit PSMA2 via 'Lys-63'-linked polyubiquitin chains (By similarity). Promotes 'Lys-48'-linked polyubiquitination SIRT7, leading to the hydrogen peroxide-induced cell death (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0043130 ubiquitin binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0040012 regulation of locomotion;GO:0043524 negative regulation of neuron apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006626 protein targeting to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FS3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64625-1", "uniprot_id": [ { "id": "GPX6_RAT", "url": "https://www.uniprot.org/uniprot/Q64625", "type": "external" } ], "mass": 24961.0, "length": 221, "protein_name": "Glutathione peroxidase 6", "gene_name": "Gpx6", "organism": "Rat", "refseq_name": "glutathione peroxidase 6 precursor", "refseq_ac": [ { "id": "NP_671694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_671694", "type": "external" } ], "gene_names_uniprotkb": "Gpx6", "gene_names_refseq": "Gpx6; OBPII; Ry2d1", "protein_names_uniprotkb": "Glutathione peroxidase 6; 1.11.1.9; GPx-6; GSHPx-6; Odorant-metabolizing protein RY2D1", "protein_names_refseq": "GPx-6; GSHPx-6; glutathione peroxidase 6 precursor; odorant-metabolizing protein RY2D1", "tax_id": 10116, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (rno:259233); (R-RNO-3299685)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1931961;37761814", "class_list": "", "function": "Glutathione Peroxidase gpx1 to gpx8 Genes Expression in Experimental Brain Tumors Reveals Gender-Dependent Patterns. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidases catalyze the reduction of a variety of hydroperoxides using glutathione as a specific electron donor substrate, and thereby protect cells against oxidative damage. Expression of this gene is restricted to embryos and adult olfactory epithelium. The mouse and rat orthologs contain a cysteine (Cys) residue at the active site, unlike the human counterpart, which is a selenoprotein, containing selenocysteine (Sec) instead. [provided by RefSeq, Jul 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" } ], "go_molecular_function": "GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64625-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R431-1", "uniprot_id": [ { "id": "MGLL_RAT", "url": "https://www.uniprot.org/uniprot/Q8R431", "type": "external" } ], "mass": 33500.0, "length": 303, "protein_name": "Monoglyceride lipase", "gene_name": "Mgll", "organism": "Rat", "refseq_name": "monoglyceride lipase isoform 2", "refseq_ac": [ { "id": "NP_612511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612511", "type": "external" } ], "gene_names_uniprotkb": "Mgll; Mgl2", "gene_names_refseq": "MAGL; Mgll", "protein_names_uniprotkb": "Monoglyceride lipase; 3.1.1.23; MAGL; MGL; Monoacylglycerol lipase", "protein_names_refseq": "MGL; monoacylglycerol lipase; monoglyceride lipase isoform 2", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); alcohol use disorder (Disease Ontology:DOID:1574); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:29254); (R-RNO-1482883); (R-RNO-426048)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12136125;17649977;29292159;34185425;38518595;9341166", "class_list": "", "function": "4 weeks of post-weaning social isolation increased aggressive grooming of a novel same-sex conspecific in male and female rats. Treatment with the MAGL inhibitor MJN110 eliminated this increase in aggressive grooming in both males and females, without reducing non-aggressive social behavior. Activation of the medial prefrontal cortex was increased by social interaction but was blunted by MJN110 only in females., [RefSeq, PubMed]; Converts monoacylglycerides to free fatty acids and glycerol (PubMed:12136125). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:12136125, PubMed:17649977). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth., [UniProtKB, UniProtKB]; Hydrolysis by means of monoglyceride lipase is a primary mechanism for 2-arachidonoylglycerol inactivation in intact neurons Erratum:[Proc Natl Acad Sci U S A 2002 Oct 15;99(21):13961], [RefSeq, PubMed]; Inhibition of MAGL activates the Keap1/Nrf2 pathway to attenuate glucocorticoid-induced osteonecrosis of the femoral head., [RefSeq, PubMed]; Inhibition of MAGL attenuates Intervertebral Disc Degeneration by Delaying nucleus pulposus senescence through STING., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32PZ2", "ec_number_list": [ { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.5.1.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0042803 protein homodimerization activity;GO:0047372 monoacylglycerol lipase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0016020 membrane;GO:0030424 axon;GO:0045202 synapse", "go_biological_process": "GO:0099178 regulation of retrograde trans-synaptic signaling by endocanabinoid;GO:0045471 response to ethanol;GO:0006633 fatty acid biosynthetic process;GO:0046464 acylglycerol catabolic process;GO:0051930 regulation of sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R431-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K059-1", "uniprot_id": [ { "id": "A0A0G2K059_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K059", "type": "external" } ], "mass": 37602.0, "length": 331, "protein_name": "Calcium uniporter protein", "gene_name": "Mcu", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mcu", "gene_names_refseq": "", "protein_names_uniprotkb": "Calcium uniporter protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700)", "pathway": " (R-RNO-8949215); (R-RNO-8949664)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0042802 identical protein binding;GO:0015292 uniporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0034704 calcium channel complex;GO:1990246 uniplex complex", "go_biological_process": "GO:0006091 generation of precursor metabolites and energy;GO:0008283 cell population proliferation;GO:0016477 cell migration;GO:0019722 calcium-mediated signaling;GO:0032024 positive regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K059-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXM7-1", "uniprot_id": [ { "id": "HBS1L_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXM7", "type": "external" } ], "mass": 74774.0, "length": 679, "protein_name": "HBS1-like protein", "gene_name": "Hbs1l", "organism": "Rat", "refseq_name": "HBS1-like protein isoform 3", "refseq_ac": [ { "id": "NP_001011934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011934", "type": "external" } ], "gene_names_uniprotkb": "Hbs1l", "gene_names_refseq": "Hbs1l", "protein_names_uniprotkb": "HBS1-like protein; 3.6.5.-", "protein_names_refseq": "HBS1-like protein isoform 3; HBS1-like protein", "tax_id": 10116, "disease": "beta thalassemia (Disease Ontology:DOID:12241)", "pathway": " (rno:293408); (R-RNO-429958); (R-RNO-9954714)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003746 translation elongation factor activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:1990533 Dom34-Hbs1 complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0006417 regulation of translation;GO:0006412 translation;GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXM7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IFW6-1", "uniprot_id": [ { "id": "K1C10_RAT", "url": "https://www.uniprot.org/uniprot/Q6IFW6", "type": "external" } ], "mass": 56505.0, "length": 526, "protein_name": "Keratin, type I cytoskeletal 10", "gene_name": "Krt10", "organism": "Rat", "refseq_name": "keratin, type I cytoskeletal 10 isoform X2", "refseq_ac": [ { "id": "XP_063125642", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063125642", "type": "external" } ], "gene_names_uniprotkb": "Krt10; Ka10", "gene_names_refseq": "Ka10; Krt10", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 10; CK-10; Cytokeratin-10; K10; Keratin-10; Type I keratin Ka10", "protein_names_refseq": "keratin, type I cytoskeletal 10 isoform X2", "tax_id": 10116, "disease": "epidermolytic hyperkeratosis 2B (Disease Ontology:DOID:0061208); epidermolytic hyperkeratosis 2A (Disease Ontology:DOID:0061223); epidermolytic hyperkeratosis (Disease Ontology:DOID:4603)", "pathway": " (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15085952;34502162;38843836", "class_list": "", "function": "Plays a role in the establishment of the epidermal barrier on plantar skin. Involved in the maintenance of cell layer development and keratin filament bundles in suprabasal cells of the epithelium., [UniProtKB, UniProtKB]; Structural component of intermediate filaments in suprabasal keratinocytes of stratified epithelia. Forms heteropolymers primarily with the type II keratin KRT1, and also with KRT2, assembling into intermediate filament networks that support terminal differentiation, mechanical resilience, and epidermal barrier formation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0008092 cytoskeletal protein binding;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0009986 cell surface;GO:0001533 cornified envelope", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0008544 epidermis development;GO:0030216 keratinocyte differentiation;GO:0071277 cellular response to calcium ion;GO:0051290 protein heterotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6IFW6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUH4-1", "uniprot_id": [ { "id": "FHL1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WUH4", "type": "external" } ], "mass": 31904.0, "length": 280, "protein_name": "Four and a half LIM domains protein 1", "gene_name": "Fhl1", "organism": "Rat", "refseq_name": "four and a half LIM domains protein 1 isoform 3", "refseq_ac": [ { "id": "NP_001258128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258128", "type": "external" } ], "gene_names_uniprotkb": "Fhl1", "gene_names_refseq": "Fhl1; SLIM1", "protein_names_uniprotkb": "Four and a half LIM domains protein 1; FHL-1", "protein_names_refseq": "FHL-1; four and a half LIM domains protein 1 isoform 3; four and a half LIM domains protein 1; skeletal muscle LIM-protein 1", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); scapuloperoneal myopathy (Disease Ontology:DOID:0060253); X-linked Emery-Dreifuss muscular dystrophy 6 (Disease Ontology:DOID:0070251); reducing body myopathy 1A (Disease Ontology:DOID:0080090); reducing body myopathy 1B (Disease Ontology:DOID:0080687); Uruguay faciocardiomusculoskeletal syndrome (Disease Ontology:DOID:0112148); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); depressive disorder (Disease Ontology:DOID:1596); tuberculosis (Disease Ontology:DOID:399); myopathy (Disease Ontology:DOID:423); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acute myeloid leukemia (Disease Ontology:DOID:9119); neonatal abstinence syndrome (Disease Ontology:DOID:9828); obesity (Disease Ontology:DOID:9970); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:25177)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17161435;18756007;20149813;23628900;24265776;25975448", "class_list": "", "function": "Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading., [RefSeq, PubMed]; FHL1 exists as part of a complex, which binds gamma-actin and non-muscle myosin IIB Publication Status: Online-Only, [RefSeq, PubMed]; FHL1 may be involved in excessive cell proliferation and may represent a potential therapeutic target for pulmonary hypertension., [RefSeq, PubMed]; Hypoxia-induced downregulation of miR-206 promotes pulmonary hypertension by targeting the HIF-1alpha/Fhl-1 pathway in pulmonary artery smooth muscle cells., [RefSeq, PubMed]; May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Over-production of SLIM1 in the cells resulted in a change in the cell-shape into a spindle-like form., [RefSeq, PubMed]; These data indicate that estradiol down-regulates Fhl1 expression through its binding to the ERbeta., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044325 transmembrane transporter binding;GO:0099104 potassium channel activator activity;GO:0099103 channel activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0007517 muscle organ development;GO:0030308 negative regulation of cell growth;GO:1901381 positive regulation of potassium ion transmembrane transport;GO:2000134 negative regulation of G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WUH4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K351-1", "uniprot_id": [ { "id": "A0A0G2K351_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K351", "type": "external" } ], "mass": 26750.0, "length": 237, "protein_name": "Malectin", "gene_name": "Unc119b", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Unc119b", "gene_names_refseq": "", "protein_names_uniprotkb": "Malectin", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:288702); (R-RNO-5624138)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005929 cilium;GO:0097228 sperm principal piece;GO:0097225 sperm midpiece;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0007399 nervous system development;GO:0042953 lipoprotein transport;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K351-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYQ6-1", "uniprot_id": [ { "id": "MMAD_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYQ6", "type": "external" } ], "mass": 33052.0, "length": 296, "protein_name": "Cobalamin trafficking protein CblD", "gene_name": "Mmadhc", "organism": "Rat", "refseq_name": "cobalamin trafficking protein CblD precursor", "refseq_ac": [ { "id": "NP_001004280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004280", "type": "external" } ], "gene_names_uniprotkb": "Mmadhc", "gene_names_refseq": "CblD; Mmadhc; RGD1303272", "protein_names_uniprotkb": "Cobalamin trafficking protein CblD; CblD; Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial", "protein_names_refseq": "cobalamin trafficking protein CblD precursor; cobalamin trafficking protein CblD; methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; methylmalonic aciduria and homocystinuria type D homolog, mitochondrial; methylmalonic aciduria and homocystinuria, cblD type", "tax_id": 10116, "disease": "methylmalonic aciduria and homocystinuria type cblD (Disease Ontology:DOID:0050716)", "pathway": " (rno:362134); (R-RNO-9759218)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in cobalamin metabolism and trafficking. Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl). Promotes oxidation of cob(II)alamin bound to MMACHC. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0009235 cobalamin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYQ6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJS8-1", "uniprot_id": [ { "id": "MASP2_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJS8", "type": "external" } ], "mass": 75667.0, "length": 685, "protein_name": "Mannan-binding lectin serine protease 2", "gene_name": "Masp2; Srm", "organism": "Rat", "refseq_name": "mannan-binding lectin serine protease 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_742040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742040", "type": "external" } ], "gene_names_uniprotkb": "Masp2; Srm; Masp2; Srm", "gene_names_refseq": "MASP-2; MAp19; Masp2", "protein_names_uniprotkb": "Mannan-binding lectin serine protease 2; 3.4.21.104; MASP-2; MBL-associated serine protease 2; Mannose-binding protein-associated serine protease 2", "protein_names_refseq": "mannan-binding lectin serine peptidase 2; mannan-binding lectin serine protease 2 isoform 1 precursor; mannan-binding lectin serine protease 2; mannose binding lectin-associated serine protease-2; mannose-binding protein-associated serine protease 2", "tax_id": 10116, "disease": "", "pathway": " (rno:64459); (R-RNO-166662); (R-RNO-2855086)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10092804;10586086;10913141;12743029;15672593;17579066;28111019", "class_list": "", "function": "A lysine residue (Lys56) within the conserved motif is essential for MASP-2 binding and probably mediates the specificity of the ficolin-MASP interaction., [RefSeq, PubMed]; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine., [UniProtKB, UniProtKB, UniProtKB]; Flexibility in MASP-1 and MASP-2 provides insight on lectin pathway activation., [RefSeq, PubMed]; Precursor of a serum protease that activates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The lectin complement system is activated following association of lectins, such as MBL2, FCN1, FCN2 or FCN3, to carbohydrates on the pathogen surface. MASP2 is cleaved and activated by MASP1 in response to lectin-binding to pathogen carbohydrates. Can activate prothrombin to thrombin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Serine protease component of the lectin complement pathway, which catalyzes cleavage and activation of C2 and C4, the next components of the complement pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJP3;Q9QX83;Q9QX84;Q9QX85;Q9QX86;Q9QX87;Q9QX88;Q9QX89;Q9QX90;Q9QX91;Q9QXD4;Q9WUZ0", "ec_number_list": [ { "id": "2.5.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.16", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.104", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.104", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0009986 cell surface;GO:1905370 serine-type endopeptidase complex;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation;GO:0001867 complement activation, lectin pathway;GO:0031638 zymogen activation;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JJS8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5I7-1", "uniprot_id": [ { "id": "MYCD_RAT", "url": "https://www.uniprot.org/uniprot/Q8R5I7", "type": "external" } ], "mass": 101872.0, "length": 938, "protein_name": "Myocardin", "gene_name": "Myocd", "organism": "Rat", "refseq_name": "myocardin isoform 2", "refseq_ac": [ { "id": "NP_872608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_872608", "type": "external" } ], "gene_names_uniprotkb": "Myocd; Mycd", "gene_names_refseq": "Mycd; Myocd", "protein_names_uniprotkb": "Myocardin", "protein_names_refseq": "myocardin isoform 2; transcription factor myocardin", "tax_id": 10116, "disease": "congenital megabladder (Disease Ontology:DOID:0112014); aortic atherosclerosis (Disease Ontology:DOID:10230); dilated cardiomyopathy (Disease Ontology:DOID:12930); patent ductus arteriosus (Disease Ontology:DOID:13832); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (rno:246297)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12392995;12663482;12756293;19237536;20385216;31928221;34694145", "class_list": "", "function": "CARMN Is an Evolutionarily Conserved Smooth Muscle Cell-Specific LncRNA That Maintains Contractile Phenotype by Binding Myocardin., [RefSeq, PubMed]; Myocardin and myocardin-related transcription factor-A (MRTF-A) are upregulated in activated hepatic stellate cells and are closely associated with robustly increased actin cytoskeleton remodeling. Erratum:[Am J Physiol Gastrointest Liver Physiol. 2020 Nov 1;319(5):G637. doi: 10.1152/ajpgi.000302.2019-corr. PMID: 33141606], [RefSeq, PubMed]; Myocardin is an important component of a molecular switch for the SMC differentiation program, [RefSeq, PubMed]; Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes (By similarity). Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). Positively regulates the transcription of genes involved in vascular smooth muscle contraction (PubMed:19237536)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7M6Y4;Q8R5I8", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042826 histone deacetylase binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0070412 R-SMAD binding;GO:0035035 histone acetyltransferase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0032993 protein-DNA complex", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0001560 regulation of cell growth by extracellular stimulus;GO:0035886 vascular associated smooth muscle cell differentiation;GO:0035733 hepatic stellate cell activation;GO:0060379 cardiac muscle cell myoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R5I7-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYE7-1", "uniprot_id": [ { "id": "ITAD_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYE7", "type": "external" } ], "mass": 126600.0, "length": 1161, "protein_name": "Integrin alpha-D", "gene_name": "Itgad; Itgam", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Itgad; Itgam; Itgad; Itgam; Itgax", "gene_names_refseq": "", "protein_names_uniprotkb": "Integrin alpha-D", "protein_names_refseq": "", "tax_id": 10116, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); limb ischemia (Disease Ontology:DOID:0050852); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); thrombosis (Disease Ontology:DOID:0060903); lupus nephritis (Disease Ontology:DOID:0080162); pre-eclampsia (Disease Ontology:DOID:10591); familial hyperlipidemia (Disease Ontology:DOID:1168); diabetic angiopathy (Disease Ontology:DOID:11713); neutropenia (Disease Ontology:DOID:1227); persistent fetal circulation syndrome (Disease Ontology:DOID:13042); Behcet's disease (Disease Ontology:DOID:13241); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); glioblastoma (Disease Ontology:DOID:3068); cerebral infarction (Disease Ontology:DOID:3526); lung adenocarcinoma (Disease Ontology:DOID:3910); hyperglycemia (Disease Ontology:DOID:4195); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); abdominal aortic aneurysm (Disease Ontology:DOID:7693); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25021); (rno:64350); (R-RNO-216083)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood., [UniProtKB, UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 10, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0038023 signaling receptor activity;GO:0008201 heparin binding;GO:0043395 heparan sulfate proteoglycan binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0008305 integrin complex;GO:0034690 integrin alphaD-beta2 complex;GO:0005615 extracellular space", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0033631 cell-cell adhesion mediated by integrin;GO:0098609 cell-cell adhesion;GO:0050798 activated T cell proliferation;GO:0034113 heterotypic cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9QYE7-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IG00-1", "uniprot_id": [ { "id": "K2C4_RAT", "url": "https://www.uniprot.org/uniprot/Q6IG00", "type": "external" } ], "mass": 57667.0, "length": 536, "protein_name": "Keratin, type II cytoskeletal 4", "gene_name": "Krt4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Krt4; Kb4", "gene_names_refseq": "", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 4; CK-4; Cytokeratin-4; K4; Keratin-4; Type-II keratin Kb4", "protein_names_refseq": "", "tax_id": 10116, "disease": "white sponge nevus (Disease Ontology:DOID:0050448); white sponge nevus 1 (Disease Ontology:DOID:0081287)", "pathway": " (rno:315323); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15085952;38843836;41018975", "class_list": "", "function": "Structural component of intermediate filaments in mucosal stratified squamous epithelia. Forms heteropolymers with the type I keratin KRT13, assembling into keratin intermediate filament networks that provides structural integrity and mechanical stability of the mucosal epithelium., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0009986 cell surface;GO:0045111 intermediate filament cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0031424 keratinization;GO:0050680 negative regulation of epithelial cell proliferation;GO:0007010 cytoskeleton organization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6IG00-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K8F9-1", "uniprot_id": [ { "id": "A0A0G2K8F9_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K8F9", "type": "external" } ], "mass": 114148.0, "length": 1065, "protein_name": "Pumilio RNA-binding family member 2", "gene_name": "Pum2", "organism": "Rat", "refseq_name": "pumilio homolog 2 isoform 2", "refseq_ac": [ { "id": "NP_001421160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421160", "type": "external" } ], "gene_names_uniprotkb": "Pum2", "gene_names_refseq": "Pum2", "protein_names_uniprotkb": "Pumilio RNA-binding family member 2", "protein_names_refseq": "pumilio 2; pumilio homolog 2 isoform 2", "tax_id": 10116, "disease": "", "pathway": " (rno:298874)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19197241;22673903;31606248;32437714;37088847;39262254", "class_list": "", "function": "Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss. Publication Status: Online-Only, [RefSeq, PubMed]; Mef2-induced expression of at least three individual miRNAs of the miR379-410 cluster is required for activity-dependent dendritic outgrowth of hippocampal neurons., [RefSeq, PubMed]; MiR-495-3p promotes cardiac hypertrophy by targeting Pum2. Publication Status: Online-Only, [RefSeq, PubMed]; Pum2 mediates Sirt1 mRNA decay and exacerbates hypoxia/reoxygenation-induced cardiomyocyte apoptosis., [RefSeq, PubMed]; These results reveal that Pum2 shapes axonal transcriptomes by preventing the transport of Pumilio-binding elements -containing mRNAs into axons, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0035198 miRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0106222 lncRNA binding;GO:0062104 pumilio-response element binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006417 regulation of translation;GO:0010629 negative regulation of gene expression;GO:0060612 adipose tissue development;GO:0010608 post-transcriptional regulation of gene expression;GO:0043488 regulation of mRNA stability", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A0G2K8F9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64268-1", "uniprot_id": [ { "id": "HEP2_RAT", "url": "https://www.uniprot.org/uniprot/Q64268", "type": "external" } ], "mass": 54552.0, "length": 479, "protein_name": "Heparin cofactor 2", "gene_name": "Serpind1", "organism": "Rat", "refseq_name": "heparin cofactor 2 precursor", "refseq_ac": [ { "id": "NP_077358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077358", "type": "external" } ], "gene_names_uniprotkb": "Serpind1; Hcf2", "gene_names_refseq": "Serpind1; rls2var1", "protein_names_uniprotkb": "Heparin cofactor 2; HC-II; Heparin cofactor II; Protease inhibitor leuserpin-2; Serpin D1", "protein_names_refseq": "HC-II; heparin cofactor 2 precursor; heparin cofactor 2; heparin cofactor II; leuserpin 2; protease inhibitor leuserpin-2; serine (or cysteine) peptidase inhibitor, clade D, member 1; serine (or cysteine) proteinase inhibitor, clade D, member 1; serpin D1; serpin peptidase inhibitor, clade D (heparin cofactor), member 1", "tax_id": 10116, "disease": "disease by infectious agent (Disease Ontology:DOID:0050117); familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); heparin cofactor II deficiency (Disease Ontology:DOID:0111901); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372)", "pathway": " (rno:79224); (R-RNO-381426); (R-RNO-8957275); (R-RNO-9769733); (R-RNO-9769739); (R-RNO-9769743)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "22673903;8286422", "class_list": "", "function": "Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT) (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKA6", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64268-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES14-1", "uniprot_id": [ { "id": "GBRE_RAT", "url": "https://www.uniprot.org/uniprot/Q9ES14", "type": "external" } ], "mass": 59219.0, "length": 506, "protein_name": "Gamma-aminobutyric acid receptor subunit epsilon", "gene_name": "Gabre", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gabre", "gene_names_refseq": "", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit epsilon; GABA(A) receptor subunit epsilon; GABAAR subunit epsilon", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10804200;11122342", "class_list": "", "function": "Epsilon subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). GABARs containing epsilon subunit may also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (By similarity). GABARs containing epsilon subunit may regulate cardiac function (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O55209", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0022824 transmitter-gated monoatomic ion channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0045211 postsynaptic membrane;GO:0098794 postsynapse;GO:0034707 chloride channel complex;GO:0032590 dendrite membrane", "go_biological_process": "GO:2001226 negative regulation of chloride transport;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9ES14-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63060-1", "uniprot_id": [ { "id": "GLPK_RAT", "url": "https://www.uniprot.org/uniprot/Q63060", "type": "external" } ], "mass": 61233.0, "length": 559, "protein_name": "Glycerol kinase", "gene_name": "Gk", "organism": "Rat", "refseq_name": "glycerol kinase", "refseq_ac": [ { "id": "NP_077357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077357", "type": "external" } ], "gene_names_uniprotkb": "Gk; Gyk", "gene_names_refseq": "ASTP; Gk; Gyk", "protein_names_uniprotkb": "Glycerol kinase; 2.7.1.30; ASTP; ATP-stimulated glucocorticoid-receptor translocation promoter; ATP:glycerol 3-phosphotransferase; Glycerokinase", "protein_names_refseq": "ATP-stimulated glucocorticoid-receptor translocation promoter; ATP-stimulated glucocorticoid-receptor translocaton promoter; ATP:glycerol 3-phosphotransferase; glycerokinase; glycerol kinase", "tax_id": 10116, "disease": "glycerol kinase deficiency (Disease Ontology:DOID:0060363); familial hypercholesterolemia (Disease Ontology:DOID:13810)", "pathway": " (rno:79223); (R-RNO-75109)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "20399282;29960856;8323560", "class_list": "", "function": "Kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Sn-glycerol 3-phosphate is a crucial intermediate in various metabolic pathways, such as the synthesis of glycerolipids and triglycerides, glycogenesis, glycolysis and gluconeogenesis., [UniProtKB, UniProtKB]; This systems biology approach further emphasizes glucose kinase's essential role in central and lipid metabolism and experimentally verifies lucose kinase's alternative function of affecting glucocorticoid receptor transcription factor activity., [RefSeq, PubMed]; To further elucidate the contributions of the enzymatic (phosphorylation) and alternative (ASTP) functions of GK in adipogenesis, we performed experiments on mammalian GK and E. coli GK. We determined that the ASTP function of GK (which is absent in E. coli GK) plays a greater role than the enzymatic activity in these processes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2K785", "ec_number_list": [ { "id": "2.7.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.30", "type": "external" } ], "go_molecular_function": "GO:0004370 glycerol kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0046167 glycerol-3-phosphate biosynthetic process;GO:0006641 triglyceride metabolic process;GO:0045471 response to ethanol;GO:0019217 regulation of fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63060-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62813-1", "uniprot_id": [ { "id": "LSAMP_RAT", "url": "https://www.uniprot.org/uniprot/Q62813", "type": "external" } ], "mass": 37324.0, "length": 338, "protein_name": "Limbic system-associated membrane protein", "gene_name": "Lsamp", "organism": "Rat", "refseq_name": "limbic system-associated membrane protein isoform 2 precursor", "refseq_ac": [ { "id": "NP_058938", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058938", "type": "external" } ], "gene_names_uniprotkb": "Lsamp; Lamp", "gene_names_refseq": "Lsamp", "protein_names_uniprotkb": "Limbic system-associated membrane protein; LSAMP", "protein_names_refseq": "limbic system-associated membrane protein isoform 2 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:29561); (R-RNO-163125)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14625014;15081109;18729387;28801670;7646886", "class_list": "", "function": "It is likely that LSAMP plays a role in the regulation of exploratory behavior of rats in the novel aversive environment., [RefSeq, PubMed]; Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hippocampal mossy fiber projection., [UniProtKB]; Neurotrimin and LSAMP were identified as ADAM10 substrates that are shed from the cell surface of dorsal root ganglion (DRGs) neurons. Overexpression of LSAMP and NTM suppresses outgrowth from DRG neurons. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 465, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q6VUH9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0042734 presynaptic membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0051963 regulation of synapse assembly;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0035641 locomotory exploration behavior;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q62813-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62599-1", "uniprot_id": [ { "id": "MTA1_RAT", "url": "https://www.uniprot.org/uniprot/Q62599", "type": "external" } ], "mass": 79412.0, "length": 703, "protein_name": "Metastasis-associated protein MTA1", "gene_name": "Mta1", "organism": "Rat", "refseq_name": "metastasis-associated protein MTA1 isoform 2", "refseq_ac": [ { "id": "NP_072110", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072110", "type": "external" } ], "gene_names_uniprotkb": "Mta1; Zg29", "gene_names_refseq": "Mta1", "protein_names_uniprotkb": "Metastasis-associated protein MTA1", "protein_names_refseq": "metastasis-associated protein MTA1 isoform 2; metastasis-associated protein MTA1", "tax_id": 10116, "disease": "", "pathway": " (rno:64520); (R-RNO-3214815); (R-RNO-3232118); (R-RNO-73762); (R-RNO-8943724); (R-RNO-9937850); (R-RNO-9940951)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "10393810;10933808;22673903;24991957;25217305;28789814;32187849;7607577;8083195", "class_list": "", "function": "MTA1 and MTA2 may be involved in the regulation of ERalpha transactivation activity in the epididymis of rats to facilitate a stable environment in the lumen, [RefSeq, PubMed]; MTA1 is coexpressed with ERa and ERb in the nuclei and cytoplasm of all placental cell types., [RefSeq, PubMed]; Metastasis-associated protein 1 promotes epithelial-mesenchymal transition in idiopathic pulmonary fibrosis by up-regulating Snail expression., [RefSeq, PubMed]; The core NuRD complex metastasis-associated proteins Mta1/2 have been purified from rat NuRD chromatin cerebellar remodeling complex, [RefSeq, PubMed]; Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (By similarity). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (By similarity). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (By similarity). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (By similarity). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (By similarity). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z0N8", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0042588 zymogen granule;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0007565 female pregnancy;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q62599-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXQ4-1", "uniprot_id": [ { "id": "MTM1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXQ4", "type": "external" } ], "mass": 69352.0, "length": 602, "protein_name": "Myotubularin", "gene_name": "Mtm1", "organism": "Rat", "refseq_name": "myotubularin isoform 1", "refseq_ac": [ { "id": "NP_001013065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013065", "type": "external" } ], "gene_names_uniprotkb": "Mtm1", "gene_names_refseq": "Mtm1", "protein_names_uniprotkb": "Myotubularin; 3.1.3.95; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase", "protein_names_refseq": "X-linked myotubular myopathy gene 1; myotubularin isoform 1; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; phosphatidylinositol-3-phosphate phosphatase", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease type 4B1 (Disease Ontology:DOID:0110191); centronuclear myopathy X-linked (Disease Ontology:DOID:0111225); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); centronuclear myopathy (Disease Ontology:DOID:14717); congenital structural myopathy (Disease Ontology:DOID:422); myopathy (Disease Ontology:DOID:423)", "pathway": " (rno:288762); (R-RNO-1660499); (R-RNO-1660516); (R-RNO-1660517)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BK31", "ec_number_list": [ { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" } ], "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0004721 phosphoprotein phosphatase activity;GO:0019215 intermediate filament binding;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005770 late endosome;GO:0030175 filopodium", "go_biological_process": "GO:1902902 negative regulation of autophagosome assembly;GO:0015031 protein transport;GO:0046716 muscle cell cellular homeostasis;GO:0008333 endosome to lysosome transport;GO:0032007 negative regulation of TOR signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXQ4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64122-1", "uniprot_id": [ { "id": "MYL9_RAT", "url": "https://www.uniprot.org/uniprot/Q64122", "type": "external" } ], "mass": 19721.0, "length": 171, "protein_name": "Myosin regulatory light polypeptide 9", "gene_name": "Myl9", "organism": "Rat", "refseq_name": "myosin regulatory light polypeptide 9", "refseq_ac": [ { "id": "NP_001094355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094355", "type": "external" } ], "gene_names_uniprotkb": "Myl9; Myrl2", "gene_names_refseq": "Myl9", "protein_names_uniprotkb": "Myosin regulatory light polypeptide 9; Myosin regulatory light chain 2, smooth muscle isoform; Myosin regulatory light chain 9", "protein_names_refseq": "myosin regulatory light chain 9; myosin regulatory light polypeptide 9; myosin, light chain 9, regulatory; myosin, light polypeptide 9, regulatory", "tax_id": 10116, "disease": "megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326)", "pathway": " (rno:296313); (R-RNO-445355)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22003410;7733921;8702756", "class_list": "", "function": "Consistent upregulation of the myosin light chain protein (Myl9) with age and injury, [RefSeq, PubMed]; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005509 calcium ion binding;GO:0032036 myosin heavy chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0001725 stress fiber;GO:0030018 Z disc;GO:0030016 myofibril", "go_biological_process": "GO:0043149 stress fiber assembly;GO:0030239 myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q64122-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K7Z7-1", "uniprot_id": [ { "id": "A0A0G2K7Z7_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K7Z7", "type": "external" } ], "mass": 38707.0, "length": 335, "protein_name": "Acyltransferase", "gene_name": "Mogat1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mogat1", "gene_names_refseq": "", "protein_names_uniprotkb": "Acyltransferase; 2.3.1.-", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:363261); (R-RNO-75109)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.22", "type": "external" } ], "go_molecular_function": "GO:0003846 2-acylglycerol O-acyltransferase activity;GO:0004144 diacylglycerol O-acyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006071 glycerol metabolic process;GO:0006651 diacylglycerol biosynthetic process;GO:0019432 triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K7Z7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CG09-1", "uniprot_id": [ { "id": "MRP1_RAT", "url": "https://www.uniprot.org/uniprot/Q8CG09", "type": "external" } ], "mass": 171493.0, "length": 1532, "protein_name": "Multidrug resistance-associated protein 1", "gene_name": "Abcc1; LOC134480646", "organism": "Rat", "refseq_name": "multidrug resistance-associated protein 1", "refseq_ac": [ { "id": "NP_071617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071617", "type": "external" } ], "gene_names_uniprotkb": "Abcc1; LOC134480646; Abcc1; LOC688708; Mrp1", "gene_names_refseq": "Abcc1a; Abcc1; Avcc1a; Mrp1; Mrp", "protein_names_uniprotkb": "Multidrug resistance-associated protein 1; 7.6.2.2; 7.6.2.3; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; LTC4 transporter; Leukotriene C(4) transporter", "protein_names_refseq": "ATP-binding cassette sub-family C (CFTR/MRP) member 1a; ATP-binding cassette sub-family C member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; ATP-binding cassette, sub-family C, member 1-like; ATP-binding cassette, subfamily C (CFTR/MRP), member 1; LTC4 transporter; glutathione-S-conjugate-translocating ATPase ABCC1; leukotriene C(4) transporter; multidrug resistance protein 1; multidrug resistance-associated protein 1-like; multidrug resistance-associated protein 1; multiple drug resistance-associated protein", "tax_id": 10116, "disease": "autosomal dominant nonsyndromic deafness 77 (Disease Ontology:DOID:0112168); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (rno:24565); (R-RNO-1660661); (R-RNO-189483); (R-RNO-2142691); (R-RNO-382556); (R-RNO-9707564); (R-RNO-9753281); (R-RNO-9758890)", "pathway_count": 8, "publication_count": 11, "publication_id_list": "11208926;12423064;12867490;15129170;17050692;22673903;28298215;28577929;29393594;35887010;8662992", "class_list": "", "function": "Bile Duct Ligation Impairs Function and Expression of Mrp1 at Rat Blood-Retinal Barrier via Bilirubin-Induced P38 MAPK Pathway Activations. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency (PubMed:15129170). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells (By similarity). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; The ROS-mediated increase in the synthesis of MRP-1 and BCRP can play an important role in hyperoxaluria-promoted calcium oxalate urolithiasis by facilitating phosphatidylserine redistribution in renal epithelial cells., [RefSeq, PubMed]; The data of this study show increased Abcc1, Abcc2, and Abcc4 mRNA expression at the BBB in response to H/R stress and that Abcc gene expression is regulated by Nrf2 signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63346;Q810E4;Q810G9;Q9JHS0", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005524 ATP binding;GO:0034040 ATPase-coupled lipid transmembrane transporter activity;GO:0008559 ABC-type xenobiotic transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030054 cell junction;GO:0016324 apical plasma membrane;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0002432 granuloma formation;GO:0048708 astrocyte differentiation;GO:1903409 reactive oxygen species biosynthetic process;GO:0006954 inflammatory response;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8CG09-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TN44-1", "uniprot_id": [ { "id": "MRGB5_RAT", "url": "https://www.uniprot.org/uniprot/Q7TN44", "type": "external" } ], "mass": 40125.0, "length": 353, "protein_name": "Mas-related G protein-coupled receptor member B5", "gene_name": "Mrgprb5", "organism": "Rat", "refseq_name": "mas-related G-protein coupled receptor member B5", "refseq_ac": [ { "id": "NP_001002284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002284", "type": "external" } ], "gene_names_uniprotkb": "Mrgprb5; Mrgb5", "gene_names_refseq": "MrgB5; Mrgprb5", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member B5", "protein_names_refseq": "MAS-related gene B5; mas-related G-protein coupled receptor member B5", "tax_id": 10116, "disease": "", "pathway": " (rno:404644)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12909716", "class_list": "", "function": "Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TN44-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5I4-1", "uniprot_id": [ { "id": "GRP4_RAT", "url": "https://www.uniprot.org/uniprot/Q8R5I4", "type": "external" } ], "mass": 75405.0, "length": 678, "protein_name": "RAS guanyl-releasing protein 4", "gene_name": "Rasgrp4", "organism": "Rat", "refseq_name": "RAS guanyl-releasing protein 4", "refseq_ac": [ { "id": "NP_570837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570837", "type": "external" } ], "gene_names_uniprotkb": "Rasgrp4", "gene_names_refseq": "Rasgrp4", "protein_names_uniprotkb": "RAS guanyl-releasing protein 4", "protein_names_refseq": "RAS guanyl-releasing protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:170668); (R-RNO-5673001)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12217396;12493770;25330932", "class_list": "", "function": "Cloning of Ras guanine nucleotide releasing protein 4, and evaluation of its expression in mast cells and their bone marrow progenitors. Review article, [RefSeq, PubMed]; Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP (PubMed:12493770). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting Ras-mediated activation of PIK3CG/PI3Kgamma to promote neutrophil functional responses (By similarity). In CD117(+) dendritic cells and mast cells, participates in an lipopolysaccharide (LPS)-activated signaling pathway that stimulates the production of interferon-gamma and other pro-inflammatory cytokines by natural killer (NK) cells (By similarity). May function in mast cell differentiation (PubMed:12493770). Does not appear to be required for the development of B-cells, DC-cells, T-cells, or NK-cells (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RasGRP-4 is aberrantly expressed in fibroblast-like synoviocytes and helps regulate their growth., [RefSeq, PubMed]; RasGRP4 regulates the expression of prostaglandin D2 in mast cell, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R5I3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0019992 diacylglycerol binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009898 cytoplasmic side of plasma membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0002717 positive regulation of natural killer cell mediated immunity;GO:0030154 cell differentiation;GO:0007265 Ras protein signal transduction;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0140367 antibacterial innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R5I4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIL5-1", "uniprot_id": [ { "id": "GLBL3_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIL5", "type": "external" } ], "mass": 72324.0, "length": 631, "protein_name": "Beta-galactosidase-1-like protein 3", "gene_name": "Glb1l3", "organism": "Rat", "refseq_name": "beta-galactosidase-1-like protein 3 precursor", "refseq_ac": [ { "id": "NP_001019529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019529", "type": "external" } ], "gene_names_uniprotkb": "Glb1l3", "gene_names_refseq": "Glb1l3", "protein_names_uniprotkb": "Beta-galactosidase-1-like protein 3; 3.2.1.23", "protein_names_refseq": "beta-galactosidase-1-like protein 3 precursor; beta-galactosidase-1-like protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:500961); (R-RNO-2022857); (R-RNO-2024101); (R-RNO-9840310)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosylhydrolase", "function": "Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" } ], "go_molecular_function": "GO:0004565 beta-galactosidase activity", "go_cellular_component": "GO:0005773 vacuole", "go_biological_process": "GO:0019388 galactose catabolic process;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIL5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63796-1", "uniprot_id": [ { "id": "M3K12_RAT", "url": "https://www.uniprot.org/uniprot/Q63796", "type": "external" } ], "mass": 96308.0, "length": 888, "protein_name": "Mitogen-activated protein kinase kinase kinase 12", "gene_name": "Map3k12", "organism": "Rat", "refseq_name": "mitogen-activated protein kinase kinase kinase 12", "refseq_ac": [ { "id": "NP_037187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037187", "type": "external" } ], "gene_names_uniprotkb": "Map3k12; Muk", "gene_names_refseq": "DLK; MUK; Map3k12; PK; Zpk", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 12; 2.7.11.25; DLK; Dual leucine zipper bearing kinase; Leucine-zipper protein kinase; MAPK-upstream kinase; MUK; Mixed lineage kinase; ZPK", "protein_names_refseq": "MAPK-upstream kinase; Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase); Zipper (leucine) protein kinase; dual leucine zipper bearing kinase; dual leucine zipper kinase; leucine-zipper protein kinase; mitogen-activated protein kinase kinase kinase 12; mixed lineage kinase", "tax_id": 10116, "disease": "", "pathway": " (rno:25579)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12223406;26719418;32189007;8637721", "class_list": "", "function": "MUK/DLK/ZPK, and JNK activity increase potently and temporally in newly generated neurons in developing mouse telencephalon during radial migration, [RefSeq, PubMed]; May be an activator of the JNK/SAPK pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway., [UniProtKB, UniProtKB]; The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development., [RefSeq, PubMed]; These findings explain how DLK specifically mediates nerve injury responses and reveal a novel cellular mechanism that ensures the specificity of neuronal kinase signaling., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030426 growth cone", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0043687 post-translational protein modification;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007254 JNK cascade;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63796-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXR4-1", "uniprot_id": [ { "id": "HEXB_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXR4", "type": "external" } ], "mass": 61527.0, "length": 537, "protein_name": "Beta-hexosaminidase subunit beta", "gene_name": "Hexb", "organism": "Rat", "refseq_name": "beta-hexosaminidase subunit beta precursor", "refseq_ac": [ { "id": "NP_001011946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011946", "type": "external" } ], "gene_names_uniprotkb": "Hexb", "gene_names_refseq": "Hexb", "protein_names_uniprotkb": "Beta-hexosaminidase subunit beta; 3.2.1.52; Beta-N-acetylhexosaminidase subunit beta; Hexosaminidase subunit B; N-acetyl-beta-glucosaminidase subunit beta", "protein_names_refseq": "N-acetyl-beta-glucosaminidase subunit beta; beta-N-acetylhexosaminidase subunit beta; beta-hexosaminidase subunit beta precursor; beta-hexosaminidase subunit beta; hexosaminidase B; hexosaminidase subunit B", "tax_id": 10116, "disease": "spinal muscular atrophy (Disease Ontology:DOID:12377); lysosomal storage disease (Disease Ontology:DOID:3211); Sandhoff disease (Disease Ontology:DOID:3323)", "pathway": " (rno:294673); (R-RNO-2022857); (R-RNO-2024101); (R-RNO-2160916); (R-RNO-6798695); (R-RNO-9840310)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "38843836", "class_list": "glycogene;glycosylhydrolase", "function": "Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (By similarity). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0042802 identical protein binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0044877 protein-containing complex binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005764 lysosome;GO:0001669 acrosomal vesicle;GO:0042582 azurophil granule", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0006689 ganglioside catabolic process;GO:0008049 male courtship behavior;GO:0030209 dermatan sulfate proteoglycan catabolic process;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6AXR4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z244-1", "uniprot_id": [ { "id": "GMPR1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z244", "type": "external" } ], "mass": 37488.0, "length": 345, "protein_name": "GMP reductase 1", "gene_name": "Gmpr", "organism": "Rat", "refseq_name": "GMP reductase 1", "refseq_ac": [ { "id": "NP_476536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476536", "type": "external" } ], "gene_names_uniprotkb": "Gmpr; GMPR; Gmpr1", "gene_names_refseq": "GMPR 1; Gmpr1; Gmpr", "protein_names_uniprotkb": "GMP reductase 1; 1.7.1.7; GMPR 1; Guanosine 5'-monophosphate oxidoreductase 1; Guanosine monophosphate reductase 1", "protein_names_refseq": "GMP reductase 1; guanosine 5'-monophosphate oxidoreductase 1; guanosine monophosphate reductase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:117533); (R-RNO-74217)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9813009", "class_list": "", "function": "Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors., [UniProtKB, UniProtKB]; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.7.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.7", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003920 GMP reductase activity", "go_cellular_component": "GO:1902560 GMP reductase complex", "go_biological_process": "GO:0006144 purine nucleobase metabolic process;GO:0006163 purine nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z244-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3T4-1", "uniprot_id": [ { "id": "FFAR1_RAT", "url": "https://www.uniprot.org/uniprot/Q8K3T4", "type": "external" } ], "mass": 31836.0, "length": 300, "protein_name": "Free fatty acid receptor 1", "gene_name": "Ffar1", "organism": "Rat", "refseq_name": "free fatty acid receptor 1", "refseq_ac": [ { "id": "NP_695216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_695216", "type": "external" } ], "gene_names_uniprotkb": "Ffar1; Gpr40", "gene_names_refseq": "Ffar1; Gpr40", "protein_names_uniprotkb": "Free fatty acid receptor 1; G protein-coupled receptor 40", "protein_names_refseq": "G-protein coupled receptor 40; free fatty acid receptor 1", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:266607); (R-RNO-381771); (R-RNO-400511); (R-RNO-416476); (R-RNO-434316); (R-RNO-444209)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "12496284;12629551;15914509;16081037;17200419;28731171;31295865;32121640;34275493;35018806", "class_list": "", "function": "Activation of GPR40 attenuates neuroinflammation and improves neurological function via PAK4/CREB/KDM6B pathway in an experimental GMH rat model. Publication Status: Online-Only, [RefSeq, PubMed]; Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40, [RefSeq, PubMed]; G protein-coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation., [UniProtKB, UniProtKB, UniProtKB]; G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation., [UniProtKB, UniProtKB]; GPR40 promotes Ca2+ influx through up-regulation of L-type calcium channels pre-activated by glucose and membrane depolarization, [RefSeq, PubMed]; GPR40 responded to fatty acids with different on-rates, and could be occupied by endogenous agonists before assay, masking the pharmacology of the receptor, [RefSeq, PubMed]; Ginseng Gintonin Contains Ligands for GPR40 and GPR55. Publication Status: Online-Only, [RefSeq, PubMed]; Our results demonstrate that GPR40 activation rescued cell death and activated the pro-apoptotic signaling pathway in TNF-alpha-induced injury of NRK52E cells. Publication Status: Online-Only, [RefSeq, PubMed]; Overexpression of G Protein-Coupled Receptor 40 Protects Obesity-Induced Cardiomyopathy Through the SIRT1/LKB1/AMPK Pathway., [RefSeq, PubMed]; The results indicate that Pollen Typhae total flavone exerts a protective role against PA-induced impairment of GSIS involving GPR40 signaling in INS-1 cells., [RefSeq, PubMed]; These results demonstrate that OA interacts with GPR40 to increase [Ca(2+)](i) via PLC- and L-type Ca(2+) channel-mediated pathway in rat islet beta-cells, which may be link to insulin release., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005504 fatty acid binding;GO:0045125 bioactive lipid receptor activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0032024 positive regulation of insulin secretion;GO:0032691 negative regulation of interleukin-1 beta production;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K3T4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63147-1", "uniprot_id": [ { "id": "HEM0_RAT", "url": "https://www.uniprot.org/uniprot/Q63147", "type": "external" } ], "mass": 64842.0, "length": 587, "protein_name": "5-aminolevulinate synthase, erythroid-specific, mitochondrial", "gene_name": "Alas2", "organism": "Rat", "refseq_name": "5-aminolevulinate synthase, erythroid-specific, mitochondrial", "refseq_ac": [ { "id": "NP_037329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037329", "type": "external" } ], "gene_names_uniprotkb": "Alas2; Alase", "gene_names_refseq": "Alas2", "protein_names_uniprotkb": "5-aminolevulinate synthase, erythroid-specific, mitochondrial; 2.3.1.37; 5-aminolevulinic acid synthase 2; ALAS-E; Delta-ALA synthase 2; Delta-aminolevulinate synthase 2", "protein_names_refseq": "5-aminolevulinate synthase, erythroid-specific, mitochondrial; 5-aminolevulinic acid synthase 2; ALAS-E; Aminolevulinate synthase 2, delta; aminolevulinate, delta-, synthase 2; aminolevulinic acid synthase 2, erythroid-like; aminolevulinic acid synthase 2, erythroid; delta-ALA synthase 2; delta-ALA synthetase; delta-aminolevulinate synthase 2; erythroid-specific delta-aminolevulinate synthase ALAS-E", "tax_id": 10116, "disease": "Perrault syndrome (Disease Ontology:DOID:0050857); sideroblastic anemia 1 (Disease Ontology:DOID:0060063); erythropoietic protoporphyria (Disease Ontology:DOID:13270); cutaneous porphyria (Disease Ontology:DOID:13271); hemochromatosis (Disease Ontology:DOID:2352); anemia (Disease Ontology:DOID:2355); bilirubin metabolic disorder (Disease Ontology:DOID:2741); acute intermittent porphyria (Disease Ontology:DOID:3890); hemolytic anemia (Disease Ontology:DOID:583); sideroblastic anemia (Disease Ontology:DOID:8955)", "pathway": " (rno:25748); (R-RNO-189451)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "2369125;8407861", "class_list": "", "function": "Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (PubMed:8407861). Contributes significantly to heme formation during erythropoiesis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63895", "ec_number_list": [ { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" } ], "go_molecular_function": "GO:0120225 coenzyme A binding;GO:0030170 pyridoxal phosphate binding;GO:0003870 5-aminolevulinate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0010288 response to lead ion;GO:0001666 response to hypoxia;GO:0006879 intracellular iron ion homeostasis;GO:0030218 erythrocyte differentiation;GO:0060135 maternal process involved in female pregnancy", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63147-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIS9-1", "uniprot_id": [ { "id": "K1C9_RAT", "url": "https://www.uniprot.org/uniprot/Q8CIS9", "type": "external" } ], "mass": 63009.0, "length": 618, "protein_name": "Keratin, type I cytoskeletal 9", "gene_name": "Krt9", "organism": "Rat", "refseq_name": "keratin, type I cytoskeletal 9", "refseq_ac": [ { "id": "NP_703206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_703206", "type": "external" } ], "gene_names_uniprotkb": "Krt9; Krt1-9", "gene_names_refseq": "Krt1-9; Krt9", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 9; CK-9; Cytokeratin-9; K9; Keratin-9; Spermatid perinuclear ring manchette protein K9", "protein_names_refseq": "CK-9; K9; cytokeratin-9; keratin 9 (epidermolytic palmoplantar keratoderma); keratin 9, type I; keratin complex 1, acidic, gene 9; keratin, type I cytoskeletal 9; spermatid perinuclear ring manchette protein K9", "tax_id": 10116, "disease": "epidermolytic palmoplantar keratoderma 1 (Disease Ontology:DOID:0070552)", "pathway": " (rno:266717); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "11071770", "class_list": "", "function": "Structural component of intermediate filaments in suprabasal keratinocytes of palmoplantar epidermis. Forms heteropolymers with a type II keratin, assembling into keratin intermediate filament networks that maintain the mechanical integrity of the palmoplantar epidermis (By similarity). May be involved in spermatid nuclear shaping and sperm development (PubMed:11071770)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0030280 structural constituent of skin epidermis;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0048471 perinuclear region of cytoplasm;GO:0045095 keratin filament;GO:0005882 intermediate filament", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030855 epithelial cell differentiation;GO:0043588 skin development;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CIS9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80T18-1", "uniprot_id": [ { "id": "GMFG_RAT", "url": "https://www.uniprot.org/uniprot/Q80T18", "type": "external" } ], "mass": 16779.0, "length": 142, "protein_name": "Glia maturation factor gamma", "gene_name": "Gmfg", "organism": "Rat", "refseq_name": "glia maturation factor gamma isoform 1", "refseq_ac": [ { "id": "NP_851605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851605", "type": "external" } ], "gene_names_uniprotkb": "Gmfg", "gene_names_refseq": "Gmfg", "protein_names_uniprotkb": "Glia maturation factor gamma; GMF-gamma", "protein_names_refseq": "GMF-gamma; glia maturation factor gamma isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:113940); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10731725", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008083 growth factor activity;GO:0019207 kinase regulator activity;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0071846 actin filament debranching;GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80T18-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6L711-1", "uniprot_id": [ { "id": "HABP2_RAT", "url": "https://www.uniprot.org/uniprot/Q6L711", "type": "external" } ], "mass": 62093.0, "length": 558, "protein_name": "Factor VII-activating protease", "gene_name": "Habp2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Habp2", "gene_names_refseq": "", "protein_names_uniprotkb": "Factor VII-activating protease; 3.4.21.-; FSAP; Hepatocyte growth factor activator-like protein; Hyaluronan-binding protein 2; PHBP; Plasma hyaluronan-binding protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "thrombophilia due to thrombin defect (Disease Ontology:DOID:0111907); pulmonary fibrosis (Disease Ontology:DOID:3770); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (rno:292126)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII. May function as a tumor suppressor negatively regulating cell proliferation and cell migration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:1904975 response to bleomycin;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6L711-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTY9-1", "uniprot_id": [ { "id": "MK13_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTY9", "type": "external" } ], "mass": 42051.0, "length": 366, "protein_name": "Mitogen-activated protein kinase 13", "gene_name": "Mapk13", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mapk13", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitogen-activated protein kinase 13; 2.7.11.24; MAP kinase 13; MAP kinase p38 delta; MAPK 13; Mitogen-activated protein kinase p38 delta; Stress-activated protein kinase 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:29513); (R-RNO-168638); (R-RNO-4420097)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10066767;20090411;20626350;20826544", "class_list": "", "function": "Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004707 MAP kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0072709 cellular response to sorbitol;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0006970 response to osmotic stress;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WTY9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHZ9-1", "uniprot_id": [ { "id": "DDIT4_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHZ9", "type": "external" } ], "mass": 24885.0, "length": 229, "protein_name": "DNA damage-inducible transcript 4 protein", "gene_name": "Ddit4", "organism": "Rat", "refseq_name": "DNA damage-inducible transcript 4 protein", "refseq_ac": [ { "id": "NP_543182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543182", "type": "external" } ], "gene_names_uniprotkb": "Ddit4; Redd1; Rtp801", "gene_names_refseq": "Ddit4; Rtp801", "protein_names_uniprotkb": "DNA damage-inducible transcript 4 protein; HIF-1 responsive protein RTP801; Protein regulated in development and DNA damage response 1; REDD-1", "protein_names_refseq": "DNA damage-inducible transcript 4 protein; HIF-1 responsive RTP801; HIF-1 responsive protein RTP801; REDD-1; protein regulated in development and DNA damage response 1", "tax_id": 10116, "disease": "", "pathway": " (rno:140942); (R-RNO-5628897)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11884613;12045667;15452091;17005863;17074751;19118169;21368030;27105917;27233899;32732871;33745924;36375964", "class_list": "", "function": "Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis, [RefSeq, PubMed]; In a PC12 model of Parkinson disease, RTP801 overexpression is sufficient to promote death but does not further elevate death caused by 6-OHDA., [RefSeq, PubMed]; In conclusion, miRNA-221 exerts cytoprotective effects in hypoxia-reoxygenation injury in association with alterations in autophagic cell injury. Mir-221 may constitute is a novel therapeutic target in the treatment of cardiac I/R injury., [RefSeq, PubMed]; LncRNA-MIAT promotes neural cell autophagy and apoptosis in ischemic stroke by up-regulating REDD1., [RefSeq, PubMed]; REDD1 functions upstream of Tuberin and Rheb to down-regulate mTOR signaling in response to dexamethasone, [RefSeq, PubMed]; Redd1 expressions is markedly changed in the hippocampal CA1 region following chronic cerebral hypoperfusion., [RefSeq, PubMed]; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes. Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death., [UniProtKB, PubMed, PubMed, PubMed]; Synaptic RTP801 contributes to motor-learning dysfunction in Huntington's disease. Publication Status: Online-Only, [RefSeq, PubMed]; The regulatory roles of DDIT4 in TDCIPP-induced autophagy and apoptosis in PC12 cells., [RefSeq, PubMed]; Thrombin and erythrocyte lysate are involved in HIF-1alpha upregulation through reducing HIF-1alpha degradation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0051607 defense response to virus;GO:0001666 response to hypoxia;GO:0001764 neuron migration;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VHZ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHN2-1", "uniprot_id": [ { "id": "LY65C_RAT", "url": "https://www.uniprot.org/uniprot/Q8CHN2", "type": "external" } ], "mass": 15985.0, "length": 145, "protein_name": "Lymphocyte antigen 6 complex locus protein G5c", "gene_name": "Ly6g5c", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ly6g5c; Re8", "gene_names_refseq": "", "protein_names_uniprotkb": "Lymphocyte antigen 6 complex locus protein G5c; Epididymal secretory protein 8; Protein RE8", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:294245)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14695977;15060004", "class_list": "", "function": "May have a role in hematopoietic cell differentiation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6MG54", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009897 external side of plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CHN2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1J4-1", "uniprot_id": [ { "id": "MYOC_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1J4", "type": "external" } ], "mass": 56442.0, "length": 502, "protein_name": "Myocilin", "gene_name": "Myoc", "organism": "Rat", "refseq_name": "myocilin precursor", "refseq_ac": [ { "id": "NP_110492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110492", "type": "external" } ], "gene_names_uniprotkb": "Myoc; Tigr", "gene_names_refseq": "Myoc; Tigr", "protein_names_uniprotkb": "Myocilin; Myocilin 20 kDa N-terminal fragment; Myocilin 35 kDa N-terminal fragment; Trabecular meshwork-induced glucocorticoid response protein", "protein_names_refseq": "myocilin precursor; myocilin, trabecular meshwork inducible glucocorticoid response; trabecular meshwork-induced glucocorticoid response protein", "tax_id": 10116, "disease": "open-angle glaucoma (Disease Ontology:DOID:1067); juvenile glaucoma (Disease Ontology:DOID:1068); primary open angle glaucoma (Disease Ontology:DOID:1070); low tension glaucoma (Disease Ontology:DOID:13544); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); ocular hypertension (Disease Ontology:DOID:9282)", "pathway": " (rno:81523)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10833334;23629661;30945300", "class_list": "", "function": "IL-8 increased myocilin expression, Akt phosphorylation, FoxO3 dispersion throughout the cytoplasm, and reduced FoxO3 level. IL-8 decreased the expression of atrogin and MuRF1 and increased myotube length and diameter., [RefSeq, PubMed]; Myocilin also stimulated osteogenic differentiation of wild-type MSCs, which was associated with activation of the p38, Erk1/2, and JNK MAP kinase signaling pathways, [RefSeq, PubMed]; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z2Y4", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0046872 metal ion binding;GO:0030971 receptor tyrosine kinase binding;GO:0001968 fibronectin binding;GO:0032027 myosin light chain binding", "go_cellular_component": "GO:0035748 myelin sheath abaxonal region;GO:0005615 extracellular space;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0007165 signal transduction;GO:0030335 positive regulation of cell migration;GO:0031175 neuron projection development;GO:0046330 positive regulation of JNK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9R1J4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JID2-1", "uniprot_id": [ { "id": "GNA11_RAT", "url": "https://www.uniprot.org/uniprot/Q9JID2", "type": "external" } ], "mass": 42026.0, "length": 359, "protein_name": "Guanine nucleotide-binding protein subunit alpha-11", "gene_name": "Gna11", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein subunit alpha-11", "refseq_ac": [ { "id": "NP_112295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112295", "type": "external" } ], "gene_names_uniprotkb": "Gna11", "gene_names_refseq": "Gna11; Hg1k", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit alpha-11; G alpha-11; G protein subunit alpha-11", "protein_names_refseq": "g alpha-11; guanine nucleotide binding protein, alpha 11; guanine nucleotide regulatory protein G alpha 11; guanine nucleotide-binding protein alpha 11 subunit; guanine nucleotide-binding protein subunit alpha-11; heterotrimeric guanine nucleotide-binding protein 1k", "tax_id": 10116, "disease": "familial hypocalciuric hypercalcemia 2 (Disease Ontology:DOID:0060701); autosomal dominant hypocalcemia 2 (Disease Ontology:DOID:0090108); McCune Albright syndrome (Disease Ontology:DOID:1858); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:81662); (R-RNO-112043); (R-RNO-202040); (R-RNO-399997); (R-RNO-416476); (R-RNO-418592); (R-RNO-428930); (R-RNO-434316); (R-RNO-456926); (R-RNO-9856530); (R-RNO-9860927)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "21649864;23696743", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems., [UniProtKB, UniProtKB]; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNA11 activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (By similarity). Together with GNAQ, required for heart development (By similarity). In the respiratory epithelium, transmits OXGR1-dependent signals that lead to downstream intracellular Ca(2+) release and mucocilliary clearance of airborne pathogens., [UniProtKB, UniProtKB, UniProtKB]; Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Galpha(q/11)--p63RhoGEF--RhoA axis., [RefSeq, PubMed]; The secretory response to luminal propionate in rat colon is mediated by G-protein on cholesterol-rich membrane microdomains, provably via Galpha(q/11) ., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098793 presynapse;GO:0005834 heterotrimeric G-protein complex;GO:0045202 synapse", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0086100 endothelin receptor signaling pathway;GO:0045634 regulation of melanocyte differentiation;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JID2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4F2-1", "uniprot_id": [ { "id": "LX15B_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4F2", "type": "external" } ], "mass": 76145.0, "length": 677, "protein_name": "Polyunsaturated fatty acid lipoxygenase ALOX15B", "gene_name": "Alox15b", "organism": "Rat", "refseq_name": "polyunsaturated fatty acid lipoxygenase ALOX15B", "refseq_ac": [ { "id": "NP_695213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_695213", "type": "external" } ], "gene_names_uniprotkb": "Alox15b", "gene_names_refseq": "Alox15b", "protein_names_uniprotkb": "Polyunsaturated fatty acid lipoxygenase ALOX15B; 1.13.11.-; 1.13.11.33; 15-LOX-2; 15-LOX-B; 15-lipoxygenase 2; Arachidonate 15-lipoxygenase B; Arachidonate 15-lipoxygenase type II; Linoleate 13-lipoxygenase 15-LOb", "protein_names_refseq": "15-LOX-2; 15-LOX-B; 15-lipoxygenase 2; arachidonate 15-lipoxygenase B; arachidonate 15-lipoxygenase type II; arachidonate 15-lipoxygenase, second type; linoleate 13-lipoxygenase 15-LOb; polyunsaturated fatty acid lipoxygenase ALOX15B", "tax_id": 10116, "disease": "", "pathway": " (rno:266604); (R-RNO-2142770)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "23382512;24376652;28024685", "class_list": "", "function": "Consistent with the decreases in the 15-LOX metabolites, expression levels of the genes that encode the 15-LOXs, Alox15 and Alox15b, were largely reduced in Olmsted syndrome model rats., [RefSeq, PubMed]; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids (PUFAs) generating a spectrum of bioactive lipid mediators (PubMed:23382512). Inserts a peroxyl group at C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing (15S)-hydroperoxyeicosatetraenoate/(15S)-HPETE (PubMed:23382512). Also peroxidizes linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE (PubMed:23382512). Oxygenates arachidonyl derivatives such as 2-arachidonoylglycerol (2-AG) leading to the production and extracellular release of 15-hydroxyeicosatetraenoyl glycerol (15-HETE-G) that acts as a peroxisome proliferator-activated receptor alpha agonist. Has the ability to efficiently class-switch ALOX5 pro-inflammatory mediators into anti-inflammatory intermediates. Participates in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) resolvin D5 ((7S,17S)-diHPDHA), which can actively down-regulate the immune response and have anti-aggregation properties with platelets. In addition to free PUFAs hydrolyzed from phospholipids, it directly oxidizes PUFAs esterified to membrane-bound phospholipids. Has no detectable 8S-lipoxygenase activity on arachidonate but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells (By similarity)., [UniProtKB, PubMed, UniProtKB]; Positive feedback-loop of TERT and 15-lipoxygenase-2 promotes pulmonary hypertension. Erratum:[PLoS One. 2024 Aug 8;19(8):e0308871. doi: 10.1371/journal.pone.0308871. PMID: 39116122] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.31", "type": "external" }, { "id": "1.13.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.33", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0005509 calcium ion binding;GO:0008289 lipid binding;GO:0016165 linoleate 13S-lipoxygenase activity;GO:0036403 arachidonate 8(S)-lipoxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0071926 endocannabinoid signaling pathway;GO:0034440 lipid oxidation;GO:0006629 lipid metabolic process;GO:0008285 negative regulation of cell population proliferation;GO:0032722 positive regulation of chemokine production", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K4F2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63648-1", "uniprot_id": [ { "id": "MERL_RAT", "url": "https://www.uniprot.org/uniprot/Q63648", "type": "external" } ], "mass": 68712.0, "length": 586, "protein_name": "Merlin", "gene_name": "Nf2", "organism": "Rat", "refseq_name": "merlin", "refseq_ac": [ { "id": "NP_037325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037325", "type": "external" } ], "gene_names_uniprotkb": "Nf2", "gene_names_refseq": "Nf2; merlin", "protein_names_uniprotkb": "Merlin; Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomin", "protein_names_refseq": "merlin; moesin-ezrin-radixin-like protein; neurofibromatosis 2; neurofibromin-2; schwannomin", "tax_id": 10116, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); autosomal recessive nonsyndromic deafness 68 (Disease Ontology:DOID:0110519); vestibular schwannomatosis (Disease Ontology:DOID:0111252); otitis media (Disease Ontology:DOID:10754); coloboma (Disease Ontology:DOID:12270); acoustic neuroma (Disease Ontology:DOID:12689); epilepsy (Disease Ontology:DOID:1826); carcinoma (Disease Ontology:DOID:305); neurilemmoma (Disease Ontology:DOID:3192); meningioma (Disease Ontology:DOID:3565); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); familial meningioma (Disease Ontology:DOID:4586); hepatocellular carcinoma (Disease Ontology:DOID:684); malignant pleural mesothelioma (Disease Ontology:DOID:7474); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:25744)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "29709009;38185389;9022813", "class_list": "", "function": "Activation of the melanocortin-1 receptor attenuates neuronal apoptosis after traumatic brain injury by upregulating Merlin expression., [RefSeq, PubMed]; Beta-AR stimulation affects post-translational modifications of NF2 via the involvement beta1-AR/PKA/cAMP pathway, and NF2 plays a pro-apoptotic role in beta-AR-stimulated myocyte apoptosis via the phosphorylation (inactivation) of YAP and involvement of mitochondrial death pathway Publication Status: Online-Only, [RefSeq, PubMed]; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex Plays a role in lens development and is required for complete fiber cell terminal differentiation, maintenance of cell polarity and separation of the lens vesicle from the corneal epithelium., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005178 integrin binding;GO:0019904 protein domain specific binding;GO:0008013 beta-catenin binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005769 early endosome", "go_biological_process": "GO:1902966 positive regulation of protein localization to early endosome;GO:0035330 regulation of hippo signaling;GO:1902115 regulation of organelle assembly;GO:0008285 negative regulation of cell population proliferation;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63648-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62912-1", "uniprot_id": [ { "id": "MAD3_RAT", "url": "https://www.uniprot.org/uniprot/Q62912", "type": "external" } ], "mass": 23671.0, "length": 206, "protein_name": "Max dimerization protein 3", "gene_name": "Mxd3", "organism": "Rat", "refseq_name": "max dimerization protein 3", "refseq_ac": [ { "id": "NP_665716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665716", "type": "external" } ], "gene_names_uniprotkb": "Mxd3; Mad3", "gene_names_refseq": "Mad3; Mxd3; Myx", "protein_names_uniprotkb": "Max dimerization protein 3; Max dimerizer 3; Max-associated protein 3; Max-interacting transcriptional repressor MAD3; Myx", "protein_names_refseq": "max dimerization protein 3; max dimerizer 3; max-associated protein 3; max-interacting transcriptional repressor MAD3", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:252915)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0090575 RNA polymerase II transcription regulator complex;GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q62912-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5G2-1", "uniprot_id": [ { "id": "MUTYH_RAT", "url": "https://www.uniprot.org/uniprot/Q8R5G2", "type": "external" } ], "mass": 57919.0, "length": 516, "protein_name": "Adenine DNA glycosylase", "gene_name": "Mutyh", "organism": "Rat", "refseq_name": "adenine DNA glycosylase", "refseq_ac": [ { "id": "NP_579850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579850", "type": "external" } ], "gene_names_uniprotkb": "Mutyh; Myh", "gene_names_refseq": "Mutyh; Myh", "protein_names_uniprotkb": "Adenine DNA glycosylase; 3.2.2.31; MutY homolog; rMYH", "protein_names_refseq": "a/G-specific adenine DNA glycosylase; adenine DNA glycosylase; mutY homolog; rMYH", "tax_id": 10116, "disease": "familial adenomatous polyposis (Disease Ontology:DOID:0050424); familial adenomatous polyposis 2 (Disease Ontology:DOID:0080410); stomach cancer (Disease Ontology:DOID:10534); stomach carcinoma (Disease Ontology:DOID:5517)", "pathway": " (rno:170841); (R-RNO-110331); (R-RNO-110357)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11948257;14690527", "class_list": "", "function": "Adenine glycosylase active on G-A mispairs., [UniProtKB, UniProtKB, UniProtKB]; Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Levels of MutY DNA glycosylase are detected in rat brain at the embryonic stage, decrease during embryonic and neonatal development, while new isoforms appear and gradually increase in the neonate and adult brain., [RefSeq, PubMed]; Respiratory hypoxia leads to increased expression of MYH in the rat brain, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.2.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.31", "type": "external" } ], "go_molecular_function": "GO:0032357 oxidized purine DNA binding;GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0019104 DNA N-glycosylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0006284 base-excision repair;GO:0006298 mismatch repair;GO:0060546 negative regulation of necroptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R5G2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IFW3-1", "uniprot_id": [ { "id": "K1C39_RAT", "url": "https://www.uniprot.org/uniprot/Q6IFW3", "type": "external" } ], "mass": 54338.0, "length": 481, "protein_name": "Keratin, type I cytoskeletal 39", "gene_name": "Krt39", "organism": "Rat", "refseq_name": "keratin, type I cytoskeletal 39", "refseq_ac": [ { "id": "NP_001004130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004130", "type": "external" } ], "gene_names_uniprotkb": "Krt39; Ka35", "gene_names_refseq": "Ka35; Krt39", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 39; CK-39; Cytokeratin-39; K39; Keratin-39; Type I hair keratin Ka35", "protein_names_refseq": "CK-39; K39; cytokeratin-39; keratin 39, type I; keratin, type I cytoskeletal 39; type I hair keratin KA35", "tax_id": 10116, "disease": "", "pathway": " (rno:303523); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15085952", "class_list": "", "function": "May play a role in late hair differentiation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0030280 structural constituent of skin epidermis;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005882 intermediate filament;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0045103 intermediate filament-based process;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IFW3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P7A9-1", "uniprot_id": [ { "id": "LYAG_RAT", "url": "https://www.uniprot.org/uniprot/Q6P7A9", "type": "external" } ], "mass": 106207.0, "length": 953, "protein_name": "Lysosomal alpha-glucosidase", "gene_name": "Gaa", "organism": "Rat", "refseq_name": "lysosomal alpha-glucosidase precursor", "refseq_ac": [ { "id": "NP_954549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954549", "type": "external" } ], "gene_names_uniprotkb": "Gaa", "gene_names_refseq": "Gaa", "protein_names_uniprotkb": "Lysosomal alpha-glucosidase; 3.2.1.20; Acid maltase", "protein_names_refseq": "acid (Pompe disease, glycogen storage disease type II); acid alpha-glucosidase; acid maltase; glucosidase, alpha, acid; glucosidase, alpha; lysosomal alpha-glucosidase precursor; lysosomal alpha-glucosidase", "tax_id": 10116, "disease": "glycogen storage disease II (Disease Ontology:DOID:2752)", "pathway": " (rno:367562); (R-RNO-6798695); (R-RNO-70221)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "24090084;38843836", "class_list": "glycogene;glycosylhydrolase", "function": "Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" } ], "go_molecular_function": "GO:0004558 alpha-1,4-glucosidase activity;GO:0030246 carbohydrate binding;GO:0090599 alpha-glucosidase activity;GO:0043896 glucan 1,6-alpha-glucosidase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0120282 autolysosome lumen", "go_biological_process": "GO:0007626 locomotory behavior;GO:0046716 muscle cell cellular homeostasis;GO:0050885 neuromuscular process controlling balance;GO:0005977 glycogen metabolic process;GO:0003007 heart morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6P7A9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1100000010000.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6VBQ5-1", "uniprot_id": [ { "id": "MYADM_RAT", "url": "https://www.uniprot.org/uniprot/Q6VBQ5", "type": "external" } ], "mass": 35148.0, "length": 318, "protein_name": "Myeloid-associated differentiation marker", "gene_name": "Myadm", "organism": "Rat", "refseq_name": "myeloid-associated differentiation marker", "refseq_ac": [ { "id": "NP_899161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899161", "type": "external" } ], "gene_names_uniprotkb": "Myadm", "gene_names_refseq": "Myadm", "protein_names_uniprotkb": "Myeloid-associated differentiation marker; Myeloid up-regulated protein", "protein_names_refseq": "myeloid up-regulated protein; myeloid-associated differentiation marker", "tax_id": 10116, "disease": "", "pathway": " (rno:369016)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0045121 membrane raft;GO:0001726 ruffle;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0031579 membrane raft organization;GO:0044860 protein localization to plasma membrane raft;GO:0061028 establishment of endothelial barrier;GO:0010629 negative regulation of gene expression;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6VBQ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERE4-1", "uniprot_id": [ { "id": "GOLP3_RAT", "url": "https://www.uniprot.org/uniprot/Q9ERE4", "type": "external" } ], "mass": 33780.0, "length": 298, "protein_name": "Golgi phosphoprotein 3", "gene_name": "Golph3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Golph3; Gmx33; Gpp34", "gene_names_refseq": "", "protein_names_uniprotkb": "Golgi phosphoprotein 3; Coat protein GPP34; Trans-Golgi protein GMx33", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:78961)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11208086;16236792;22673903", "class_list": "", "function": "Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0140312 cargo adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005768 endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0072752 cellular response to rapamycin;GO:0045053 protein retention in Golgi apparatus;GO:0090164 asymmetric Golgi ribbon formation;GO:0016477 cell migration;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9ERE4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIQ4-1", "uniprot_id": [ { "id": "MGRN1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIQ4", "type": "external" } ], "mass": 58603.0, "length": 533, "protein_name": "E3 ubiquitin-protein ligase MGRN1", "gene_name": "Mgrn1", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase MGRN1 isoform 7", "refseq_ac": [ { "id": "NP_001013986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013986", "type": "external" } ], "gene_names_uniprotkb": "Mgrn1", "gene_names_refseq": "Mgrn1; RGD1311862", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MGRN1; 2.3.2.27; Mahogunin RING finger protein 1; RING-type E3 ubiquitin transferase MGRN1", "protein_names_refseq": "E3 ubiquitin-protein ligase MGRN1 isoform 7; RING-type E3 ubiquitin transferase MGRN1; mahoganoid; mahogunin RING finger protein 1; mahogunin ring finger 1, E3 ubiquitin protein ligase; probable E3 ubiquitin-protein ligase MGRN1", "tax_id": 10116, "disease": "", "pathway": " (rno:302938); (R-RNO-983168)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22673903;28475871;38843836", "class_list": "", "function": "E3 ubiquitin ligase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Also acts as a negative regulator of hedgehog signaling (By similarity)., [UniProtKB, UniProtKB]; With aging, the neuroprotective e3 ligase MGRN1 relocates from the cytosol to the nucleus of neurons, where it associates with chromatin and potentiates the cellular response to proteotoxic stress. This nuclear shift is due to a proteasome impairment dependent increase of a monoubiquitinated form of MGRN1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007507 heart development;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0008333 endosome to lysosome transport;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5XIQ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIT9-1", "uniprot_id": [ { "id": "MCCB_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIT9", "type": "external" } ], "mass": 61517.0, "length": 563, "protein_name": "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "gene_name": "Mccc2", "organism": "Rat", "refseq_name": "methylcrotonoyl-CoA carboxylase beta chain, mitochondrial", "refseq_ac": [ { "id": "NP_001012177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012177", "type": "external" } ], "gene_names_uniprotkb": "Mccc2", "gene_names_refseq": "Mccc2", "protein_names_uniprotkb": "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; 3-methylcrotonyl-CoA carboxylase 2; 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; 6.4.1.4; MCCase subunit beta", "protein_names_refseq": "3-methylcrotonyl-CoA carboxylase 2; 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; MCCase subunit beta; methylcrotonoyl-CoA carboxylase 2 (beta); methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; methylcrotonoyl-Coenzyme A carboxylase 2 (beta)", "tax_id": 10116, "disease": "3-methylcrotonyl-CoA carboxylase 2 deficiency (Disease Ontology:DOID:0080580); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (rno:361884); (R-RNO-196780); (R-RNO-70895)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "6.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.1", "type": "external" }, { "id": "6.4.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004485 methylcrotonoyl-CoA carboxylase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:1905202 methylcrotonoyl-CoA carboxylase complex", "go_biological_process": "GO:0015936 coenzyme A metabolic process;GO:0006552 L-leucine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIT9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIV2-1", "uniprot_id": [ { "id": "MARHA_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIV2", "type": "external" } ], "mass": 87886.0, "length": 790, "protein_name": "Probable E3 ubiquitin-protein ligase MARCHF10", "gene_name": "Marchf10", "organism": "Rat", "refseq_name": "probable E3 ubiquitin-protein ligase MARCHF10", "refseq_ac": [ { "id": "NP_001013995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013995", "type": "external" } ], "gene_names_uniprotkb": "Marchf10; March10; Rnf190", "gene_names_refseq": "MARCH-X; March10; Marchf10; RGD1311692; Rnf190", "protein_names_uniprotkb": "Probable E3 ubiquitin-protein ligase MARCHF10; 2.3.2.27; MARCH-X; Membrane-associated RING finger protein 10; Membrane-associated RING-CH protein X; RING finger protein 190; RING-type E3 ubiquitin transferase MARCHF10", "protein_names_refseq": "RING-type E3 ubiquitin transferase MARCH10; RING-type E3 ubiquitin transferase MARCHF10; membrane-associated RING finger protein 10; membrane-associated RING-CH protein X; membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase; microtubule-associated E3 ubiquitin ligase; probable E3 ubiquitin-protein ligase MARCH10; probable E3 ubiquitin-protein ligase MARCHF10; ring finger protein 190", "tax_id": 10116, "disease": "", "pathway": " (rno:303596)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIV2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIX3-1", "uniprot_id": [ { "id": "DCR1C_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIX3", "type": "external" } ], "mass": 78189.0, "length": 698, "protein_name": "Protein artemis", "gene_name": "Dclre1c", "organism": "Rat", "refseq_name": "protein artemis", "refseq_ac": [ { "id": "NP_671486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_671486", "type": "external" } ], "gene_names_uniprotkb": "Dclre1c; Snm1l", "gene_names_refseq": "Dclre1c; Snm1l", "protein_names_uniprotkb": "Protein artemis; 3.1.-.-; DNA cross-link repair 1C protein; SNM1-like protein", "protein_names_refseq": "DNA cross-link repair 1C protein; SNM1-like protein; protein artemis", "tax_id": 10116, "disease": "Omenn syndrome (Disease Ontology:DOID:0060010); severe combined immunodeficiency with sensitivity to ionizing radiation (Disease Ontology:DOID:0090012); common variable immunodeficiency (Disease Ontology:DOID:12177); severe combined immunodeficiency (Disease Ontology:DOID:627)", "pathway": " (rno:259171); (R-RNO-5693571)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation, and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4H7", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0000014 single-stranded DNA endodeoxyribonuclease activity;GO:0035312 5'-3' DNA exonuclease activity;GO:0008409 5'-3' exonuclease activity;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0070419 nonhomologous end joining complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0000723 telomere maintenance;GO:0002250 adaptive immune response;GO:0006302 double-strand break repair;GO:0006303 double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIX3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62661-1", "uniprot_id": [ { "id": "HBP1_RAT", "url": "https://www.uniprot.org/uniprot/Q62661", "type": "external" } ], "mass": 57430.0, "length": 513, "protein_name": "HMG box-containing protein 1", "gene_name": "Hbp1", "organism": "Rat", "refseq_name": "HMG box-containing protein 1", "refseq_ac": [ { "id": "NP_037353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037353", "type": "external" } ], "gene_names_uniprotkb": "Hbp1", "gene_names_refseq": "Hbp1; Hmgb1", "protein_names_uniprotkb": "HMG box-containing protein 1; HMG box transcription factor 1; High mobility group box transcription factor 1", "protein_names_refseq": "HMG box-containing protein 1; high mobility group box transcription factor 1; high mobility group protein 1", "tax_id": 10116, "disease": "osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (rno:27080)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11748221;22673903;31139836;34653689;35033142;7937077;9178770", "class_list": "", "function": "Anti-high-mobility group box-1 (HMGB1) mediates the apoptosis of alveolar epithelial cells (AEC) by receptor of advanced glycation end-products (RAGE)/c-Jun N-terminal kinase (JNK) pathway in the rats of crush injuries. Publication Status: Online-Only, [RefSeq, PubMed]; IGF-1 alleviates CCL4-induced hepatic cirrhosis and dysfunction of intestinal barrier through inhibition TLR4/NF-kappaB signaling mediated by down-regulation HMGB1., [RefSeq, PubMed]; Our results have led us to propose that HMGB1 may play a central role in the stabilization and/or assembly of several multifunctional complexes through protein-protein interactions, [RefSeq, PubMed]; These observations suggested, for the first time, that HMGB1 plays a critical role in the pathogenesis of acute necrotizing pancreatitis by affecting intestinal permeability and autophagy., [RefSeq, PubMed]; Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BK86", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62661-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62714-1", "uniprot_id": [ { "id": "DEF4_RAT", "url": "https://www.uniprot.org/uniprot/Q62714", "type": "external" } ], "mass": 10110.0, "length": 93, "protein_name": "Defensin alpha 4", "gene_name": "Np4", "organism": "Rat", "refseq_name": "defensin alpha 4 precursor", "refseq_ac": [ { "id": "NP_775421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775421", "type": "external" } ], "gene_names_uniprotkb": "Np4", "gene_names_refseq": "NP-4; Np4", "protein_names_uniprotkb": "Defensin alpha 4; Neutrophil antibiotic peptide NP-4; Neutrophil defensin 4; RatNP-4", "protein_names_refseq": "defensin 3b; defensin alpha 4 precursor; defensin alpha 4; neutrophil antibiotic peptide NP-4; neutrophil defensin 4; ratNP-4", "tax_id": 10116, "disease": "", "pathway": " (rno:286958); (R-RNO-1461973); (R-RNO-1462054); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "2543629;7594610", "class_list": "", "function": "Host-defense peptide that has antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi (in vitro) (PubMed:2543629). Exhibits activity against E.coli, A.calcoaceticus, S,aureus and C.albicans (PubMed:2543629)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0042582 azurophil granule", "go_biological_process": "GO:0006952 defense response;GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62714-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62722-1", "uniprot_id": [ { "id": "NAB1_RAT", "url": "https://www.uniprot.org/uniprot/Q62722", "type": "external" } ], "mass": 54026.0, "length": 485, "protein_name": "NGFI-A-binding protein 1", "gene_name": "Nab1", "organism": "Rat", "refseq_name": "NGFI-A-binding protein 1", "refseq_ac": [ { "id": "NP_074047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_074047", "type": "external" } ], "gene_names_uniprotkb": "Nab1", "gene_names_refseq": "Nab1", "protein_names_uniprotkb": "NGFI-A-binding protein 1; EGR-1-binding protein 1", "protein_names_refseq": "EGR-1-binding protein 1; NGFI-A-binding protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:64824)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12470865;18456662;7624335;9418898", "class_list": "", "function": "Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Also represses multiple types of non-EGR1 activation domains (in vitro)., [UniProtKB, PubMed]; Egr2 directly represses genes during myelination in conjunction with NAB corepressors, [RefSeq, PubMed]; NGFI-A protein expression in the developing striatum appears to be driven first by dopaminergic afferents, and then later in development by excitatory glutamatergic afferents., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0042552 myelination;GO:0045892 negative regulation of DNA-templated transcription;GO:0014037 Schwann cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62722-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62724-1", "uniprot_id": [ { "id": "MCM6_RAT", "url": "https://www.uniprot.org/uniprot/Q62724", "type": "external" } ], "mass": 57370.0, "length": 507, "protein_name": "DNA replication licensing factor MCM6", "gene_name": "Mcm6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mcm6; Mcmd6", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA replication licensing factor MCM6; 3.6.4.12; Intestinal DNA replication protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "22673903;7590274", "class_list": "", "function": "Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0042555 MCM complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62724-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62785-1", "uniprot_id": [ { "id": "HAP28_RAT", "url": "https://www.uniprot.org/uniprot/Q62785", "type": "external" } ], "mass": 20605.0, "length": 181, "protein_name": "28 kDa heat- and acid-stable phosphoprotein", "gene_name": "Pdap1", "organism": "Rat", "refseq_name": "28 kDa heat- and acid-stable phosphoprotein", "refseq_ac": [ { "id": "NP_072117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072117", "type": "external" } ], "gene_names_uniprotkb": "Pdap1; Haspp28", "gene_names_refseq": "Haspp28; PAP; Pdap1", "protein_names_uniprotkb": "28 kDa heat- and acid-stable phosphoprotein; PAP1; PAP; PDGF-associated protein; PDGFA-associated protein 1", "protein_names_refseq": "28 kDa heat- and acid-stable phosphoprotein; PAP1; PDGF-associated protein; heat- and acid-stable phosphoprotein of 28 kDa; kinase substrate HASPP28", "tax_id": 10116, "disease": "high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (rno:64527); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16396499;22673903;8615683;8780057", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62890", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62785-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62857-1", "uniprot_id": [ { "id": "DDIT3_RAT", "url": "https://www.uniprot.org/uniprot/Q62857", "type": "external" } ], "mass": 19013.0, "length": 168, "protein_name": "DNA damage-inducible transcript 3 protein", "gene_name": "Ddit3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ddit3; Chop10; Chop; Gadd153", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA damage-inducible transcript 3 protein; C/EBP zeta; C/EBP-homologous protein 10; C/EBP-homologous protein; CCAAT/enhancer-binding protein homologous protein; CHOP-10; CHOP; DDIT-3; Growth arrest and DNA-damage-inducible protein GADD153", "protein_names_refseq": "", "tax_id": 10116, "disease": "brain ischemia (Disease Ontology:DOID:2316); nephrosis (Disease Ontology:DOID:2527); pulmonary tuberculosis (Disease Ontology:DOID:2957); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); borna disease (Disease Ontology:DOID:5154); ureteral obstruction (Disease Ontology:DOID:5199); myxoid liposarcoma (Disease Ontology:DOID:5363); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); galactosemia (Disease Ontology:DOID:9870)", "pathway": " (rno:29467)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response. Acts as a major regulator of postnatal neovascularization through regulation of endothelial nitric oxide synthase (NOS3)-related signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0036488 CHOP-C/EBP complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005770 late endosome", "go_biological_process": "GO:0032700 negative regulation of interleukin-17 production;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q62857-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62946-1", "uniprot_id": [ { "id": "MIA_RAT", "url": "https://www.uniprot.org/uniprot/Q62946", "type": "external" } ], "mass": 14536.0, "length": 130, "protein_name": "Melanoma-derived growth regulatory protein", "gene_name": "Mia", "organism": "Rat", "refseq_name": "melanoma-derived growth regulatory protein precursor", "refseq_ac": [ { "id": "NP_110479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110479", "type": "external" } ], "gene_names_uniprotkb": "Mia; Cdrap; Mia1", "gene_names_refseq": "Cdrap; Mia1; Mia", "protein_names_uniprotkb": "Melanoma-derived growth regulatory protein; CD-RAP; Cartilage-derived retinoic acid-sensitive protein; Melanoma inhibitory activity protein", "protein_names_refseq": "CD-RAP; cartilage-derived retinoic acid-sensitive protein; melanoma inhibitory activity 1; melanoma inhibitory activity protein; melanoma inhibitory activity/condrocyte-derived retinoic acid sensitive protein homolog (MIA/CD-RAP); melanoma-derived growth regulatory protein precursor; melanoma-derived growth regulatory protein-like; melanoma-derived growth regulatory protein", "tax_id": 10116, "disease": "osteonecrosis (Disease Ontology:DOID:10159)", "pathway": " (rno:81510)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15722556;8621736;9364210", "class_list": "", "function": "CREB-binding protein/p300 increase chondrocyte Cd-rap gene expression by multiple mechanisms including sequestration of the repressor CCAAT/enhancer-binding protein, [RefSeq, PubMed]; May function during cartilage development and maintenance., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97591", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62946-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62953-1", "uniprot_id": [ { "id": "MTR1L_RAT", "url": "https://www.uniprot.org/uniprot/Q62953", "type": "external" } ], "mass": 13837.0, "length": 119, "protein_name": "Melatonin-related receptor", "gene_name": "Gpr50", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gpr50", "gene_names_refseq": "", "protein_names_uniprotkb": "Melatonin-related receptor; G protein-coupled receptor 50; H9", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:117097)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8647286", "class_list": "", "function": "G protein-coupled receptor that plays a role in numerous physiological processes including regulation of energy metabolism, neurite outgrowth or cell migration. Promotes self-renewal and neuronal differentiation of neural progenitor cells through activation of the NOTCH and WNT/beta-catenin signaling pathways. Modulates the KAT5-dependent glucocorticoid receptor signaling by modulating KAT5 subcellular compartmentalisation. Also plays a role in the activation TGFBR1 in the absence of TGFBR2 by interfering with FKBP1A binding to TGFBR1, leading to induction of both canonical and non-canonical SMAD signaling pathways resulting in inhibition of proliferation or promotion of migration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008502 melatonin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62953-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63203-1", "uniprot_id": [ { "id": "FCGR2_RAT", "url": "https://www.uniprot.org/uniprot/Q63203", "type": "external" } ], "mass": 32048.0, "length": 285, "protein_name": "Low affinity immunoglobulin gamma Fc region receptor II", "gene_name": "Fcgr2", "organism": "Rat", "refseq_name": "low affinity immunoglobulin gamma Fc region receptor II isoform 2 precursor", "refseq_ac": [ { "id": "NP_786932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786932", "type": "external" } ], "gene_names_uniprotkb": "Fcgr2; Fcgr2b", "gene_names_refseq": "CD32; FCRII; FcgammaRIIB2; Fcgr2b; Fcgr2", "protein_names_uniprotkb": "Low affinity immunoglobulin gamma Fc region receptor II; Fc-gamma RII; FcRII; IgG Fc receptor II beta", "protein_names_refseq": "FC-gamma RII; Fc fragment of IgG receptor IIb; Fc fragment of IgG, low affinity IIb, receptor; Fc gamma receptor IIb; Fc receptor, IgG, low affinity IIb; igG Fc receptor II beta; low affinity immunoglobulin gamma FC region receptor II; low affinity immunoglobulin gamma Fc region receptor II isoform 2 precursor; low affinity immunoglobulin gamma Fc region receptor II-b", "tax_id": 10116, "disease": "lymphoid leukemia (Disease Ontology:DOID:1037); malaria (Disease Ontology:DOID:12365); glomerulonephritis (Disease Ontology:DOID:2921); end stage renal disease (Disease Ontology:DOID:783); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:289211); (R-RNO-198933); (R-RNO-2029481); (R-RNO-2029482); (R-RNO-2029485); (R-RNO-6798695)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "22673903;26271972;8405417", "class_list": "", "function": "Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens., [UniProtKB]; Data shew that he up-regulation of Fc gamma RIIB (FcgammaRIIB) expression in macrophages might suppress cell phagocytosis and chemotaxis., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001540 amyloid-beta binding;GO:0044877 protein-containing complex binding;GO:0019864 IgG binding;GO:0019865 immunoglobulin binding;GO:0019770 IgG receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043197 dendritic spine;GO:0055037 recycling endosome;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0038094 Fc-gamma receptor signaling pathway;GO:0002434 immune complex clearance;GO:0007166 cell surface receptor signaling pathway;GO:0016358 dendrite development;GO:0046330 positive regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63203-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63272-1", "uniprot_id": [ { "id": "JAK3_RAT", "url": "https://www.uniprot.org/uniprot/Q63272", "type": "external" } ], "mass": 122726.0, "length": 1100, "protein_name": "Tyrosine-protein kinase JAK3", "gene_name": "Jak3", "organism": "Rat", "refseq_name": "tyrosine-protein kinase JAK3", "refseq_ac": [ { "id": "NP_036987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036987", "type": "external" } ], "gene_names_uniprotkb": "Jak3; Insl3", "gene_names_refseq": "Jak3; RATJAK3", "protein_names_uniprotkb": "Tyrosine-protein kinase JAK3; 2.7.10.2; JAK-3; Janus kinase 3", "protein_names_refseq": "JAK-3; Janus kinase 3, protein-tyrosine kinase; tyrosine-protein kinase JAK3", "tax_id": 10116, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); spermatogenic failure 18 (Disease Ontology:DOID:0070165); primary ciliary dyskinesia 37 (Disease Ontology:DOID:0080266); T-cell prolymphocytic leukemia (Disease Ontology:DOID:0081042); graft-versus-host disease (Disease Ontology:DOID:0081267); T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0081312); severe combined immunodeficiency 104 (Disease Ontology:DOID:0090014); disease of cellular proliferation (Disease Ontology:DOID:14566); cancer (Disease Ontology:DOID:162); hematologic cancer (Disease Ontology:DOID:2531); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); severe combined immunodeficiency (Disease Ontology:DOID:627); acute megakaryocytic leukemia (Disease Ontology:DOID:8761)", "pathway": " (rno:25326); (R-RNO-1266695); (R-RNO-201556); (R-RNO-5673001); (R-RNO-6785807); (R-RNO-8854691); (R-RNO-8983432); (R-RNO-8985947); (R-RNO-9020558); (R-RNO-9020958); (R-RNO-912526)", "pathway_count": 11, "publication_count": 6, "publication_id_list": "28473442;29393594;30664158;33416962;33910370;8143863", "class_list": "", "function": "JAK3 mediates smooth muscle cell proliferation and survival during injury-induced vascular remodeling., [RefSeq, PubMed]; Janus Kinase 3 Deficiency Promotes Vascular Reendothelialization-Brief Report., [RefSeq, PubMed]; MicroRNA-495 alleviates ulcerative interstitial cystitis via inactivating the JAK-STAT signaling pathway by inhibiting JAK3., [RefSeq, PubMed]; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion (By similarity)., [UniProtKB]; Treatment downregulated the expression of JAK1, JAK3 and STAT3, and upregulated cytosolic nuclear factor (NF)kappaB p65 and IkappaB. In conclusion, the results of the present study indicated that curculigoside exhibited significant antiarthritic effects in vivo and in vitro, and the molecular mechanism may be associated with the JAK/STAT/NFkappaB signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F1LR79", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019903 protein phosphatase binding;GO:0005131 growth hormone receptor binding", "go_cellular_component": "GO:0005829 cytosol;GO:0031234 extrinsic component of cytoplasmic side of plasma membrane;GO:0012505 endomembrane system;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0035771 interleukin-4-mediated signaling pathway;GO:0038110 interleukin-2-mediated signaling pathway;GO:0032693 negative regulation of interleukin-10 production;GO:0002731 negative regulation of dendritic cell cytokine production;GO:0070232 regulation of T cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q63272-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63661-1", "uniprot_id": [ { "id": "MUC4_RAT", "url": "https://www.uniprot.org/uniprot/Q63661", "type": "external" } ], "mass": 248041.0, "length": 2344, "protein_name": "Mucin-4", "gene_name": "Muc4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Muc4; Smc", "gene_names_refseq": "", "protein_names_uniprotkb": "Mucin-4; ASGP-1; ASGP-2; ASGP; Ascites sialoglycoprotein 1; Ascites sialoglycoprotein 2; Ascites sialoglycoprotein; MUC-4; Pancreatic adenocarcinoma mucin; Pre-sialomucin complex; Sialomucin complex; Testis mucin; pSMC", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-913709); (R-RNO-977068)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10880365;12386815;1379596;15672420;16624867;7440586;8163496;9857062", "class_list": "", "function": "Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces. These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation. Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 31, "predicted_n_glycosites": 22, "predicted_o_glycosites": 9, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 31, "binding_glycan_count": 0, "secondary_ac_list": "Q63655;Q63657;Q63659;Q9JIC4", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0005176 ErbB-2 class receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016324 apical plasma membrane;GO:0032991 protein-containing complex;GO:0031528 microvillus membrane", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0043066 negative regulation of apoptotic process;GO:0030277 maintenance of gastrointestinal epithelium;GO:0007160 cell-matrix adhesion;GO:0001953 negative regulation of cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q63661-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64230-1", "uniprot_id": [ { "id": "MEP1A_RAT", "url": "https://www.uniprot.org/uniprot/Q64230", "type": "external" } ], "mass": 85123.0, "length": 748, "protein_name": "Meprin A subunit alpha", "gene_name": "Mep1a", "organism": "Rat", "refseq_name": "meprin A subunit alpha precursor", "refseq_ac": [ { "id": "NP_037275", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037275", "type": "external" } ], "gene_names_uniprotkb": "Mep1a", "gene_names_refseq": "Mep1a", "protein_names_uniprotkb": "Meprin A subunit alpha; 3.4.24.18; E-24.18; Endopeptidase-24.18 subunit alpha; Endopeptidase-2; MEP-1", "protein_names_refseq": "E-24.18; MEP-1; endopeptidase-24.18 subunit alpha; endopeptidase-2; meprin 1 alpha; meprin 1 subunit alpha; meprin A alpha; meprin A subunit alpha precursor", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (rno:25684)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12437103;1505684;17976009;8760356", "class_list": "", "function": "Optimization of activity by pH and NaCl concentration and relevance to catalytic mechanism, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q642C9", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0070573 metallodipeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0017090 meprin A complex", "go_biological_process": "GO:0006508 proteolysis;GO:0038004 epidermal growth factor receptor ligand maturation;GO:0140448 signaling receptor ligand precursor processing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q64230-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H06-1", "uniprot_id": [ { "id": "Q66H06_RAT", "url": "https://www.uniprot.org/uniprot/Q66H06", "type": "external" } ], "mass": 28095.0, "length": 253, "protein_name": "Tetraspanin", "gene_name": "Tspan3", "organism": "Rat", "refseq_name": "tetraspanin-3", "refseq_ac": [ { "id": "NP_001005547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005547", "type": "external" } ], "gene_names_uniprotkb": "Tspan3", "gene_names_refseq": "Tm4sf8; Tspan3", "protein_names_uniprotkb": "Tetraspanin", "protein_names_refseq": "tetraspanin-3; transmembrane 4 superfamily member 8", "tax_id": 10116, "disease": "", "pathway": " (rno:300733)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24090084", "class_list": "", "function": "Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q66H06-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H23-1", "uniprot_id": [ { "id": "MFRN1_RAT", "url": "https://www.uniprot.org/uniprot/Q66H23", "type": "external" } ], "mass": 37497.0, "length": 338, "protein_name": "Mitoferrin-1", "gene_name": "Slc25a37", "organism": "Rat", "refseq_name": "mitoferrin-1", "refseq_ac": [ { "id": "NP_001014018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014018", "type": "external" } ], "gene_names_uniprotkb": "Slc25a37; Mfrn", "gene_names_refseq": "Mscp; RGD1359361; Slc25a37", "protein_names_uniprotkb": "Mitoferrin-1; Mitochondrial iron transporter 1; Solute carrier family 25 member 37", "protein_names_refseq": "mitochondrial carrier domain containing protein RGD1359361; mitochondrial iron transporter 1; mitochondrial solute carrier-like protein; mitoferrin-1; solute carrier family 25 (mitochondrial iron transporter), member 37", "tax_id": 10116, "disease": "", "pathway": " (rno:306000)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015093 ferrous iron transmembrane transporter activity;GO:0005381 iron ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0046985 positive regulation of hemoglobin biosynthetic process;GO:0048250 iron import into the mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H23-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H42-1", "uniprot_id": [ { "id": "LYPD1_RAT", "url": "https://www.uniprot.org/uniprot/Q66H42", "type": "external" } ], "mass": 15330.0, "length": 141, "protein_name": "Ly6/PLAUR domain-containing protein 1", "gene_name": "Lypd1", "organism": "Rat", "refseq_name": "ly6/PLAUR domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_001007728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007728", "type": "external" } ], "gene_names_uniprotkb": "Lypd1; Lypdc1", "gene_names_refseq": "Lypd1; Lypdc1", "protein_names_uniprotkb": "Ly6/PLAUR domain-containing protein 1", "protein_names_refseq": "ly6/PLAUR domain-containing protein 1 precursor; ly6/PLAUR domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:360838); (R-RNO-163125)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "17488974", "class_list": "", "function": "Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety., [UniProtKB, UniProtKB]; The 3' exon of the GPR39 gene overlaps with antisense gene LYPD1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0033130 acetylcholine receptor binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse;GO:0098552 side of membrane", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0035094 response to nicotine;GO:0095500 acetylcholine receptor signaling pathway;GO:0001662 behavioral fear response;GO:1903077 negative regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66H42-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H84-1", "uniprot_id": [ { "id": "MAPK3_RAT", "url": "https://www.uniprot.org/uniprot/Q66H84", "type": "external" } ], "mass": 43222.0, "length": 384, "protein_name": "MAP kinase-activated protein kinase 3", "gene_name": "Mapkapk3", "organism": "Rat", "refseq_name": "MAP kinase-activated protein kinase 3", "refseq_ac": [ { "id": "NP_001012127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012127", "type": "external" } ], "gene_names_uniprotkb": "Mapkapk3", "gene_names_refseq": "MAPKAP-K3; MK-3; Mapkapk3", "protein_names_uniprotkb": "MAP kinase-activated protein kinase 3; 2.7.11.1; MAPK-activated protein kinase 3; MAPKAP kinase 3; MAPKAP-K3; MAPKAPK-3; MK-3", "protein_names_refseq": "MAP kinase-activated protein kinase 3; MAPKAP kinase 3; MAPKAPK-3; mitogen-activated protein kinase-activated protein kinase 3", "tax_id": 10116, "disease": "patterned macular dystrophy 3 (Disease Ontology:DOID:0060865)", "pathway": " (rno:315994); (R-RNO-171007); (R-RNO-2559580); (R-RNO-4420097); (R-RNO-450302)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0009931 calcium-dependent protein serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051019 mitogen-activated protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0035556 intracellular signal transduction;GO:0000165 MAPK cascade;GO:0034097 response to cytokine;GO:0002224 toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H84-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H95-1", "uniprot_id": [ { "id": "DIRC2_RAT", "url": "https://www.uniprot.org/uniprot/Q66H95", "type": "external" } ], "mass": 52030.0, "length": 478, "protein_name": "Solute carrier family 49 member 4", "gene_name": "Slc49a4", "organism": "Rat", "refseq_name": "solute carrier family 49 member 4", "refseq_ac": [ { "id": "NP_001012017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012017", "type": "external" } ], "gene_names_uniprotkb": "Slc49a4; Dirc2", "gene_names_refseq": "Dirc2; Slc49a4", "protein_names_uniprotkb": "Solute carrier family 49 member 4; Disrupted in renal carcinoma protein 2 homolog", "protein_names_refseq": "disrupted in renal carcinoma 2 homolog; disrupted in renal carcinoma protein 2 homolog; solute carrier family 49 member 4", "tax_id": 10116, "disease": "renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (rno:303902)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates H(+)-dependent pyridoxine transport., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0031923 pyridoxine transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H95-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HD6-1", "uniprot_id": [ { "id": "LRC18_RAT", "url": "https://www.uniprot.org/uniprot/Q66HD6", "type": "external" } ], "mass": 28845.0, "length": 256, "protein_name": "Leucine-rich repeat-containing protein 18", "gene_name": "Lrrc18", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 18", "refseq_ac": [ { "id": "NP_001014021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014021", "type": "external" } ], "gene_names_uniprotkb": "Lrrc18", "gene_names_refseq": "Lrrc18; RGD1311738", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 18", "protein_names_refseq": "leucine-rich repeat-containing protein 18", "tax_id": 10116, "disease": "", "pathway": " (rno:306278)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in the regulation of spermatogenesis and sperm maturation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HD6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HH3-1", "uniprot_id": [ { "id": "LYL1_RAT", "url": "https://www.uniprot.org/uniprot/Q66HH3", "type": "external" } ], "mass": 29957.0, "length": 278, "protein_name": "Protein lyl-1", "gene_name": "Lyl1", "organism": "Rat", "refseq_name": "protein lyl-1", "refseq_ac": [ { "id": "NP_001007678", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007678", "type": "external" } ], "gene_names_uniprotkb": "Lyl1", "gene_names_refseq": "Lyl1", "protein_names_uniprotkb": "Protein lyl-1; Lymphoblastic leukemia-derived sequence 1", "protein_names_refseq": "lymphoblastic leukemia associated hematopoiesis regulator 1; lymphoblastic leukemia-derived sequence 1; protein lyl-1-like; protein lyl-1", "tax_id": 10116, "disease": "T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (rno:304663)", "pathway_count": 1, "publication_count": 0, 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"missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0030183 B cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HH3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FP1-1", "uniprot_id": [ { "id": "GELS_RAT", "url": "https://www.uniprot.org/uniprot/Q68FP1", "type": "external" } ], "mass": 86068.0, "length": 780, "protein_name": "Gelsolin", "gene_name": "Gsn", "organism": "Rat", "refseq_name": "gelsolin precursor", "refseq_ac": [ { "id": "NP_001004080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004080", "type": "external" } ], "gene_names_uniprotkb": "Gsn", "gene_names_refseq": "Gsn", "protein_names_uniprotkb": "Gelsolin; ADF; Actin-depolymerizing factor; Brevin", "protein_names_refseq": "ADF; actin-depolymerizing factor; brevin; gelsolin precursor", "tax_id": 10116, "disease": "Finnish type amyloidosis (Disease Ontology:DOID:0050637); pre-eclampsia (Disease Ontology:DOID:10591); hypothyroidism (Disease Ontology:DOID:1459); cerebral infarction (Disease Ontology:DOID:3526); myocardial infarction (Disease Ontology:DOID:5844); rheumatic myocarditis (Disease Ontology:DOID:8481); lung disease (Disease Ontology:DOID:850); gas gangrene (Disease Ontology:DOID:9159)", "pathway": " (rno:296654); (R-RNO-264870); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21454685", "class_list": "", "function": "Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (By similarity). Plays a role in ciliogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045159 myosin II binding;GO:0003779 actin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0014891 striated muscle atrophy;GO:0097017 renal protein absorption;GO:1902174 positive regulation of keratinocyte apoptotic process;GO:1903903 regulation of establishment of T cell polarity;GO:1903906 regulation of plasma membrane raft polarization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68FP1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FV6-1", "uniprot_id": [ { "id": "GLMP_RAT", "url": "https://www.uniprot.org/uniprot/Q68FV6", "type": "external" } ], "mass": 43871.0, "length": 404, "protein_name": "Glycosylated lysosomal membrane protein", "gene_name": "Glmp", "organism": "Rat", "refseq_name": "glycosylated lysosomal membrane protein precursor", "refseq_ac": [ { "id": "NP_001004226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004226", "type": "external" } ], "gene_names_uniprotkb": "Glmp", "gene_names_refseq": "0610031j06rik; Glmp; RGD1303130", "protein_names_uniprotkb": "Glycosylated lysosomal membrane protein; Lysosomal protein NCU-G1", "protein_names_refseq": "glycosylated lysosomal membrane protein precursor; kidney predominant protein NCU-G1; lysosomal protein NCU-G1", "tax_id": 10116, "disease": "", "pathway": " (rno:295231)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050821 protein stabilization;GO:0061462 protein localization to lysosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FV6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXT1-1", "uniprot_id": [ { "id": "FHL5_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXT1", "type": "external" } ], "mass": 32970.0, "length": 284, "protein_name": "Four and a half LIM domains protein 5", "gene_name": "Fhl5", "organism": "Rat", "refseq_name": "four and a half LIM domains protein 5", "refseq_ac": [ { "id": "NP_001013106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013106", "type": "external" } ], "gene_names_uniprotkb": "Fhl5", "gene_names_refseq": "Fhl5", "protein_names_uniprotkb": "Four and a half LIM domains protein 5; FHL-5", "protein_names_refseq": "FHL-5; four and a half LIM domains protein 5", "tax_id": 10116, "disease": "", "pathway": " (rno:297954)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0030018 Z disc", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXT1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXU6-1", "uniprot_id": [ { "id": "JUPI1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXU6", "type": "external" } ], "mass": 15575.0, "length": 149, "protein_name": "Jupiter microtubule associated homolog 1", "gene_name": "Jpt1", "organism": "Rat", "refseq_name": "jupiter microtubule associated homolog 1", "refseq_ac": [ { "id": "NP_001005876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005876", "type": "external" } ], "gene_names_uniprotkb": "Jpt1; Hn1", "gene_names_refseq": "Hn1; Jpt1", "protein_names_uniprotkb": "Jupiter microtubule associated homolog 1; Hematological and neurological expressed 1 protein", "protein_names_refseq": "hematological and neurological expressed 1 protein; hematological and neurological expressed sequence 1; jupiter microtubule associated homolog 1", "tax_id": 10116, "disease": "", "pathway": " (rno:287828)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXU6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXU8-1", "uniprot_id": [ { "id": "METL6_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXU8", "type": "external" } ], "mass": 33381.0, "length": 287, "protein_name": "tRNA N(3)-cytidine methyltransferase METTL6", "gene_name": "Mettl6; Sh3bp5", "organism": "Rat", "refseq_name": "tRNA N(3)-cytidine methyltransferase METTL6", "refseq_ac": [ { "id": "NP_001007624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007624", "type": "external" } ], "gene_names_uniprotkb": "Mettl6; Sh3bp5; Mettl6; Sh3bp5", "gene_names_refseq": "Mettl6", "protein_names_uniprotkb": "tRNA N(3)-cytidine methyltransferase METTL6; 2.1.1.-; Methyltransferase-like protein 6", "protein_names_refseq": "methyltransferase 6, methylcytidine; methyltransferase like 6; methyltransferase-like protein 6; tRNA N(3)-cytidine methyltransferase METTL6; tRNA N(3)-methylcytidine methyltransferase METTL6", "tax_id": 10116, "disease": "", "pathway": " (rno:290564)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35591810", "class_list": "", "function": "Functions as guanine nucleotide exchange factor (GEF) for RAB11A., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mechanism of METTL3-mediated m6A modification in depression-induced cognitive deficits., [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser), including tRNA(Ser)(UGA) and tRNA(Ser)(GCU). Interaction with SARS1/SerRS is required for N(3)-methylcytidine methylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0052735 tRNA (cytidine-3-)-methyltransferase activity;GO:0017124 SH3 domain binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0043527 tRNA methyltransferase complex;GO:0030659 cytoplasmic vesicle membrane;GO:0016604 nuclear body", "go_biological_process": "GO:0006400 tRNA modification;GO:0030488 tRNA methylation;GO:0106217 tRNA C3-cytosine methylation;GO:0035556 intracellular signal transduction;GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXU8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXV9-1", "uniprot_id": [ { "id": "GSTO2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXV9", "type": "external" } ], "mass": 28679.0, "length": 248, "protein_name": "Glutathione S-transferase omega-2", "gene_name": "Gsto2", "organism": "Rat", "refseq_name": "glutathione S-transferase omega-2", "refseq_ac": [ { "id": "NP_001012071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012071", "type": "external" } ], "gene_names_uniprotkb": "Gsto2", "gene_names_refseq": "GSTO 2-2; Gsto2", "protein_names_uniprotkb": "Glutathione S-transferase omega-2; 1.20.4.2; 1.8.5.1; 2.5.1.18; GSTO 2-2; GSTO-2; Glutathione S-transferase omega 2-2; Glutathione-dependent dehydroascorbate reductase; MMA(V) reductase; Monomethylarsonic acid reductase", "protein_names_refseq": "GSTO-2; MMA(V) reductase; glutathione S-transferase omega 2-2; glutathione S-transferase omega-2; glutathione-dependent dehydroascorbate reductase; monomethylarsonic acid reductase", "tax_id": 10116, "disease": "amyotrophic lateral sclerosis type 6 (Disease Ontology:DOID:0060198); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); asthma (Disease Ontology:DOID:2841)", "pathway": " (rno:309465); (R-RNO-156590); (R-RNO-196836)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0042802 identical protein binding;GO:0016491 oxidoreductase activity;GO:0045174 glutathione dehydrogenase (ascorbate) activity;GO:0050610 methylarsonate reductase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0019852 L-ascorbic acid metabolic process;GO:0071243 cellular response to arsenic-containing substance;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXV9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY53-1", "uniprot_id": [ { "id": "DHYS_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY53", "type": "external" } ], "mass": 40705.0, "length": 369, "protein_name": "Deoxyhypusine synthase", "gene_name": "Dhps", "organism": "Rat", "refseq_name": "deoxyhypusine synthase", "refseq_ac": [ { "id": "NP_001004207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004207", "type": "external" } ], "gene_names_uniprotkb": "Dhps", "gene_names_refseq": "Dhps", "protein_names_uniprotkb": "Deoxyhypusine synthase; 2.5.1.46; DHS", "protein_names_refseq": "DHS; deoxyhypusine synthase", "tax_id": 10116, "disease": "", "pathway": " (rno:288923); (R-RNO-204626)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.46", "type": "external" } ], "go_molecular_function": "GO:0034038 deoxyhypusine synthase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008216 spermidine metabolic process;GO:0046203 spermidine catabolic process;GO:0042593 glucose homeostasis;GO:0042102 positive regulation of T cell proliferation;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY53-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY79-1", "uniprot_id": [ { "id": "HGH1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY79", "type": "external" } ], "mass": 43132.0, "length": 393, "protein_name": "Co-chaperone protein HGH1 homolog", "gene_name": "Hgh1", "organism": "Rat", "refseq_name": "co-chaperone protein HGH1 homolog", "refseq_ac": [ { "id": "NP_001007708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007708", "type": "external" } ], "gene_names_uniprotkb": "Hgh1; Brp16; Fam203a", "gene_names_refseq": "Brp16; Fam203a; Hgh1", "protein_names_uniprotkb": "Co-chaperone protein HGH1 homolog", "protein_names_refseq": "brain protein 16; co-chaperone protein HGH1 homolog; family with sequence similarity 203, member A; protein FAM203A; protein HGH1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:315094)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Co-chaperone involved in the folding of nascent eukaryotic elongation factor eEF2, an essential component of the translation machinery. Recognizes a non-native conformation in the central domain of eEF2 and recruits the chaperonin-containing T-complex (TRiC) to the C-terminal region of the nascent polypeptide, preventing unproductive interactions and promoting efficient folding of the N-terminal GTPase domain. May also assist in eEF2 maturation by recruiting the molecular chaperone Hsp90., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY79-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYB8-1", "uniprot_id": [ { "id": "GO45_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYB8", "type": "external" } ], "mass": 45089.0, "length": 400, "protein_name": "Golgin-45", "gene_name": "Blzf1", "organism": "Rat", "refseq_name": "golgin-45", "refseq_ac": [ { "id": "NP_001017494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017494", "type": "external" } ], "gene_names_uniprotkb": "Blzf1", "gene_names_refseq": "Blzf1", "protein_names_uniprotkb": "Golgin-45; Basic leucine zipper nuclear factor 1", "protein_names_refseq": "golgin-45", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:498266); (R-RNO-162658)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11739401", "class_list": "", "function": "Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0043001 Golgi to plasma membrane protein transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYB8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYD1-1", "uniprot_id": [ { "id": "MBLC1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYD1", "type": "external" } ], "mass": 26137.0, "length": 251, "protein_name": "Metallo-beta-lactamase domain-containing protein 1", "gene_name": "Mblac1", "organism": "Rat", "refseq_name": "metallo-beta-lactamase domain-containing protein 1", "refseq_ac": [ { "id": "NP_001020167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020167", "type": "external" } ], "gene_names_uniprotkb": "Mblac1", "gene_names_refseq": "Mblac1; RGD1306932", "protein_names_uniprotkb": "Metallo-beta-lactamase domain-containing protein 1; 3.1.27.-; Endoribonuclease MBLAC1", "protein_names_refseq": "endoribonuclease MBLAC1; metallo-beta-lactamase domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:304346)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase. Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop. May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:0031124 mRNA 3'-end processing;GO:0008334 histone mRNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYD1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYF6-1", "uniprot_id": [ { "id": "GL8D1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYF6", "type": "external" } ], "mass": 42135.0, "length": 371, "protein_name": "Glycosyltransferase 8 domain-containing protein 1", "gene_name": "Glt8d1", "organism": "Rat", "refseq_name": "glycosyltransferase 8 domain-containing protein 1", "refseq_ac": [ { "id": "NP_001007684", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007684", "type": "external" } ], "gene_names_uniprotkb": "Glt8d1", "gene_names_refseq": "Da2-24; Glt8d1", "protein_names_uniprotkb": "Glycosyltransferase 8 domain-containing protein 1; 2.4.1.-", "protein_names_refseq": "glycosyltransferase 8 domain-containing protein 1; glycosyltransferase AD-017", "tax_id": 10116, "disease": "", "pathway": " (rno:306253)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "In vitro, catalyzes the transfer of a galactose residue from UDP-galactose onto GalNAc and GlcNAc structures., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYF6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYF7-1", "uniprot_id": [ { "id": "MFAP3_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYF7", "type": "external" } ], "mass": 38397.0, "length": 347, "protein_name": "Microfibril-associated glycoprotein 3", "gene_name": "Mfap3", "organism": "Rat", "refseq_name": "microfibril-associated glycoprotein 3 precursor", "refseq_ac": [ { "id": "NP_001007610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007610", "type": "external" } ], "gene_names_uniprotkb": "Mfap3", "gene_names_refseq": "Mfap3", "protein_names_uniprotkb": "Microfibril-associated glycoprotein 3", "protein_names_refseq": "microfibril-associated glycoprotein 3 precursor; microfibril-associated glycoprotein 3; microfibrillar-associated protein 3; neuroprotective protein 10", "tax_id": 10116, "disease": "", "pathway": " (rno:287299)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the elastin-associated microfibrils., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYF7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYL8-1", "uniprot_id": [ { "id": "LRIQ3_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYL8", "type": "external" } ], "mass": 75120.0, "length": 633, "protein_name": "Leucine-rich repeat and IQ domain-containing protein 3", "gene_name": "Lrriq3", "organism": "Rat", "refseq_name": "leucine-rich repeat and IQ domain-containing protein 3", "refseq_ac": [ { "id": "NP_001019478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019478", "type": "external" } ], "gene_names_uniprotkb": "Lrriq3; Lrrc44", "gene_names_refseq": "Lrrc44; Lrriq3", "protein_names_uniprotkb": "Leucine-rich repeat and IQ domain-containing protein 3; Leucine-rich repeat-containing protein 44", "protein_names_refseq": "leucine rich repeat containing 44; leucine-rich repeat and IQ domain-containing protein 3; leucine-rich repeat-containing protein 44", "tax_id": 10116, "disease": "", "pathway": " (rno:499732)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYL8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYM7-1", "uniprot_id": [ { "id": "MAJIN_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYM7", "type": "external" } ], "mass": 28646.0, "length": 251, "protein_name": "Membrane-anchored junction protein", "gene_name": "Majin", "organism": "Rat", "refseq_name": "membrane-anchored junction protein", "refseq_ac": [ { "id": "NP_001019462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019462", "type": "external" } ], "gene_names_uniprotkb": "Majin", "gene_names_refseq": "Majin", "protein_names_uniprotkb": "Membrane-anchored junction protein", "protein_names_refseq": "hypothetical gene supported by BC078985; membrane-anchored junction protein; uncharacterized protein C11orf85 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:499306)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0031965 nuclear membrane;GO:0005637 nuclear inner membrane;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0090435 protein localization to nuclear envelope;GO:0007283 spermatogenesis;GO:0070197 meiotic attachment of telomere to nuclear envelope;GO:0048477 oogenesis;GO:0007129 homologous chromosome pairing at meiosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYM7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYQ0-1", "uniprot_id": [ { "id": "MAGIX_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYQ0", "type": "external" } ], "mass": 34743.0, "length": 326, "protein_name": "PDZ domain-containing protein MAGIX", "gene_name": "Magix", "organism": "Rat", "refseq_name": "PDZ domain-containing protein MAGIX", "refseq_ac": [ { "id": "NP_001014131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014131", "type": "external" } ], "gene_names_uniprotkb": "Magix", "gene_names_refseq": "Magix", "protein_names_uniprotkb": "PDZ domain-containing protein MAGIX", "protein_names_refseq": "PDZ domain-containing protein MAGIX", "tax_id": 10116, "disease": "", "pathway": " (rno:317379)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYQ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYS8-1", "uniprot_id": [ { "id": "DHB11_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYS8", "type": "external" } ], "mass": 32938.0, "length": 298, "protein_name": "Estradiol 17-beta-dehydrogenase 11", "gene_name": "Hsd17b11", "organism": "Rat", "refseq_name": "estradiol 17-beta-dehydrogenase 11 precursor", "refseq_ac": [ { "id": "NP_001004209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004209", "type": "external" } ], "gene_names_uniprotkb": "Hsd17b11; Dhrs8", "gene_names_refseq": "Dhrs8; Hsd17b11", "protein_names_uniprotkb": "Estradiol 17-beta-dehydrogenase 11; 1.1.1.62; 17-beta-HSD 11; 17-beta-HSD XI; 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-hydroxysteroid dehydrogenase XI; 17bHSD11; 17betaHSD11; 17betaHSDXI; Dehydrogenase/reductase SDR family member 8", "protein_names_refseq": "17-beta-HSD 11; 17-beta-HSD XI; 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-hydroxysteroid dehydrogenase XI; 17bHSD11; 17betaHSD11; 17betaHSDXI; dehydrogenase/reductase SDR family member 8; estradiol 17-beta-dehydrogenase 11 precursor; estradiol 17-beta-dehydrogenase 11", "tax_id": 10116, "disease": "", "pathway": " (rno:289456); (R-RNO-193144)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18775470;21454685;36849008", "class_list": "", "function": "Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione., [UniProtKB]; Hydroxysteroid 17beta-dehydrogenase 11 accumulation on lipid droplets promotes ethanol-induced cellular steatosis., [RefSeq, PubMed]; The localization studies on rat short-chain dehydrogenases/reductases dhrs7b and dhrs8, are shown., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.64", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" } ], "go_molecular_function": "GO:0016229 steroid dehydrogenase activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "GO:0006710 androgen catabolic process;GO:0006694 steroid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6AYS8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GX83-1", "uniprot_id": [ { "id": "GXLT1_RAT", "url": "https://www.uniprot.org/uniprot/Q6GX83", "type": "external" } ], "mass": 50243.0, "length": 435, "protein_name": "Glucoside xylosyltransferase 1", "gene_name": "Gxylt1", "organism": "Rat", "refseq_name": "glucoside xylosyltransferase 1", "refseq_ac": [ { "id": "NP_001094357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094357", "type": "external" } ], "gene_names_uniprotkb": "Gxylt1; Glt8d3", "gene_names_refseq": "Glt8d3; Gxylt1", "protein_names_uniprotkb": "Glucoside xylosyltransferase 1; 2.4.2.42; Glycosyltransferase 8 domain-containing protein 3; S33-D", "protein_names_refseq": "S33-D; glucoside xylosyltransferase 1; glycosyltransferase 8 domain containing 3; glycosyltransferase 8 domain-containing protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:300173)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16288221", "class_list": "", "function": "Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.42", "type": "external" } ], "go_molecular_function": "GO:0035252 UDP-xylosyltransferase activity;GO:0140563 UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine;GO:0180059 protein O-linked glycosylation via glucose", "synthesized_glycan_count": 7, "hit_score": 0.2, "record_id": "Q6GX83-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IFV1-1", "uniprot_id": [ { "id": "K1C14_RAT", "url": "https://www.uniprot.org/uniprot/Q6IFV1", "type": "external" } ], "mass": 52684.0, "length": 485, "protein_name": "Keratin, type I cytoskeletal 14", "gene_name": "Krt14", "organism": "Rat", "refseq_name": "keratin, type I cytoskeletal 14", "refseq_ac": [ { "id": "NP_001008751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008751", "type": "external" } ], "gene_names_uniprotkb": "Krt14; Ka14; Krt1-14", "gene_names_refseq": "Ka14; Krt1-14; Krt14", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 14; CK-14; Cytokeratin-14; K14; Keratin-14; Type I keratin Ka14", "protein_names_refseq": "CK-14; K14; cytokeratin-14; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin complex 1, acidic, gene 14; keratin, type I cytoskeletal 14; type I keratin Ka14", "tax_id": 10116, "disease": "generalized severe epidermolysis bullosa simplex 1A (Disease Ontology:DOID:0060735); dermatopathia pigmentosa reticularis (Disease Ontology:DOID:0111342); Naegeli-Franceschetti-Jadassohn syndrome (Disease Ontology:DOID:0111528); epidermolysis bullosa simplex (Disease Ontology:DOID:4644); esophagus small cell carcinoma (Disease Ontology:DOID:7134)", "pathway": " (rno:287701); (R-RNO-446107); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "15085952;26956522;34502162;8950218", "class_list": "", "function": "Structural component of intermediate filaments in basal keratinocytes of stratified epithelia. Forms obligate heteropolymers with the type II keratin KRT5, contributing to the keratin intermediate filament network that confers mechanical strength and structural integrity to the basal layer of the epidermis and other stratified epithelial. The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro., [UniProtKB, UniProtKB]; These findings strongly suggest that Krt-14 regulates osteoblast mineralization by organizing osteoblast derived ECM., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35813", "ec_number_list": [], "go_molecular_function": "GO:1990254 keratin filament binding;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0045178 basal part of cell;GO:0005882 intermediate filament", "go_biological_process": "GO:0045110 intermediate filament bundle assembly;GO:0010043 response to zinc ion;GO:0030855 epithelial cell differentiation;GO:0030216 keratinocyte differentiation;GO:0010212 response to ionizing radiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6IFV1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IFV4-1", "uniprot_id": [ { "id": "K1C13_RAT", "url": "https://www.uniprot.org/uniprot/Q6IFV4", "type": "external" } ], "mass": 47729.0, "length": 438, "protein_name": "Keratin, type I cytoskeletal 13", "gene_name": "Krt13", "organism": "Rat", "refseq_name": "keratin, type I cytoskeletal 13", "refseq_ac": [ { "id": "NP_001004021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004021", "type": "external" } ], "gene_names_uniprotkb": "Krt13; Ka13", "gene_names_refseq": "Ka13; Krt13", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 13; CK-13; Cytokeratin-13; K13; Keratin-13; Type I keratin Ka13", "protein_names_refseq": "CK-13; K13; cytokeratin-13; keratin 13, type I; keratin, type I cytoskeletal 13; type I keratin KA13", "tax_id": 10116, "disease": "white sponge nevus (Disease Ontology:DOID:0050448); white sponge nevus 2 (Disease Ontology:DOID:0081288)", "pathway": " (rno:287699); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15085952;18262229;34502162", "class_list": "", "function": "K13 immunoreactivity was generally evident in the suprabasal cells of the interpapillary cell columns and K14 immunoreactivity was detected in the basal and suprabasal cells of the papillary and interpapillary cell columns, [RefSeq, PubMed]; Structural component of intermediate filaments in mucosal stratified squamous epithelia. Forms heteropolymers with the type II keratin KRT4, assembling into keratin intermediate filament networks that provides structural integrity and mechanical stability of the mucosal epithelium (By similarity). Contributes to postnatal tongue mucosal cell homeostasis and tissue organization in response to mechanical stress, potentially through regulation of the G1/S phase cyclins CCNE1 and CCNE2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0070062 extracellular exosome;GO:0045111 intermediate filament cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0043555 regulation of translation in response to stress;GO:0030855 epithelial cell differentiation;GO:0071300 cellular response to retinoic acid;GO:0007010 cytoskeleton organization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6IFV4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IFW8-1", "uniprot_id": [ { "id": "K1C27_RAT", "url": "https://www.uniprot.org/uniprot/Q6IFW8", "type": "external" } ], "mass": 49109.0, "length": 449, "protein_name": "Keratin, type I cytoskeletal 27", "gene_name": "Krt27", "organism": "Rat", "refseq_name": "keratin, type I cytoskeletal 27", "refseq_ac": [ { "id": "NP_001008824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008824", "type": "external" } ], "gene_names_uniprotkb": "Krt27; Ka40", "gene_names_refseq": "Ka40; Krt27", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 27; CK-27; Cytokeratin-27; K27; Keratin-27; Type I inner root sheath-specific keratin-K25irs3; Type I keratin KA40", "protein_names_refseq": "CK-27; K27; cytokeratin-27; keratin 27, type I; keratin, type I cytoskeletal 27; type I inner root sheath-specific keratin-K25irs3; type I keratin KA40", "tax_id": 10116, "disease": "", "pathway": " (rno:450229); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15085952", "class_list": "", "function": "Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0031069 hair follicle morphogenesis;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IFW8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IFX0-1", "uniprot_id": [ { "id": "K1C25_RAT", "url": "https://www.uniprot.org/uniprot/Q6IFX0", "type": "external" } ], "mass": 48943.0, "length": 446, "protein_name": "Keratin, type I cytoskeletal 25", "gene_name": "Krt25", "organism": "Rat", "refseq_name": "keratin, type I cytoskeletal 25", "refseq_ac": [ { "id": "NP_001008822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008822", "type": "external" } ], "gene_names_uniprotkb": "Krt25; Ka38; Krt25a", "gene_names_refseq": "Ka38; Krt25A; Krt25", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 25; CK-25; Cytokeratin-25; K25A; K25; Keratin-25A; Keratin-25; Type I inner root sheath-specific keratin-K25irs1; Type I keratin KA38", "protein_names_refseq": "CK-25; K25A; K25; cytokeratin-25; keratin 25, type I; keratin, type I cytoskeletal 25; keratin-25A; type I inner root sheath-specific keratin-K25irs1; type I keratin KA38", "tax_id": 10116, "disease": "autosomal recessive woolly hair 3 (Disease Ontology:DOID:0111574)", "pathway": " (rno:303519); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15085952", "class_list": "", "function": "Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0030280 structural constituent of skin epidermis;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0007010 cytoskeleton organization;GO:0045109 intermediate filament organization;GO:0031069 hair follicle morphogenesis;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IFX0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IFX1-1", "uniprot_id": [ { "id": "K1C24_RAT", "url": "https://www.uniprot.org/uniprot/Q6IFX1", "type": "external" } ], "mass": 52380.0, "length": 491, "protein_name": "Keratin, type I cytoskeletal 24", "gene_name": "Krt24", "organism": "Rat", "refseq_name": "keratin, type I cytoskeletal 24", "refseq_ac": [ { "id": "NP_001004131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004131", "type": "external" } ], "gene_names_uniprotkb": "Krt24; Ka24", "gene_names_refseq": "Ka24; Krt24", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 24; CK-24; Cytokeratin-24; K24; Keratin-24; Type I keratin-24", "protein_names_refseq": "CK-24; K24; cytokeratin-24; keratin 24, type I; keratin, type I cytoskeletal 24; type I keratin KA24; type I keratin-24", "tax_id": 10116, "disease": "", "pathway": " (rno:287675); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15085952", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005882 intermediate filament;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0045103 intermediate filament-based process;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IFX1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IG05-1", "uniprot_id": [ { "id": "K2C75_RAT", "url": "https://www.uniprot.org/uniprot/Q6IG05", "type": "external" } ], "mass": 59027.0, "length": 542, "protein_name": "Keratin, type II cytoskeletal 75", "gene_name": "Krt75", "organism": "Rat", "refseq_name": "keratin, type II cytoskeletal 75 isoform 2", "refseq_ac": [ { "id": "NP_001376191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376191", "type": "external" } ], "gene_names_uniprotkb": "Krt75; Kb18", "gene_names_refseq": "CK-75; K75; Kb18; Krt75", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 75; CK-75; Cytokeratin-75; K75; Keratin-6 hair follicle; Keratin-75; Type II keratin-K6hf; Type-II keratin Kb18", "protein_names_refseq": "cytokeratin-75; keratin 75, type II; keratin, type II cytoskeletal 75 isoform 2; keratin, type II cytoskeletal 75; keratin-6 hair follicle; type II keratin-18; type II keratin-K6hf; type-II keratin Kb18", "tax_id": 10116, "disease": "", "pathway": " (rno:300247); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15085952;29393594;34502162", "class_list": "", "function": "Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005882 intermediate filament;GO:0001533 cornified envelope;GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6IG05-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG05-1", "uniprot_id": [ { "id": "Q6MG05_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG05", "type": "external" } ], "mass": 38250.0, "length": 330, "protein_name": "RT1 class I, locus T24, gene 1", "gene_name": "RT1-T24-1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RT1-T24-1", "gene_names_refseq": "", "protein_names_uniprotkb": "RT1 class I, locus T24, gene 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030670 phagocytic vesicle membrane;GO:0042612 MHC class I protein complex;GO:0098553 lumenal side of endoplasmic reticulum membrane", "go_biological_process": "GO:0002474 antigen processing and presentation of peptide antigen via MHC class I", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6MG05-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG58-1", "uniprot_id": [ { "id": "LY66D_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG58", "type": "external" } ], "mass": 14025.0, "length": 134, "protein_name": "Lymphocyte antigen 6 complex locus protein G6d", "gene_name": "Ly6g6d", "organism": "Rat", "refseq_name": "lymphocyte antigen 6 complex locus protein G6d isoform 1 precursor", "refseq_ac": [ { "id": "NP_001001970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001970", "type": "external" } ], "gene_names_uniprotkb": "Ly6g6d", "gene_names_refseq": "G6d; Ly6-D; Ly6g6d; Ng25", "protein_names_uniprotkb": "Lymphocyte antigen 6 complex locus protein G6d", "protein_names_refseq": "lymphocyte antigen 6 complex G6D; lymphocyte antigen 6 complex locus protein G6d isoform 1 precursor; lymphocyte antigen 6 complex locus protein G6d; lymphocyte antigen 6 complex, locus G6D", "tax_id": 10116, "disease": "", "pathway": " (rno:415062); (R-RNO-163125)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15060004", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0045202 synapse;GO:0009897 external side of plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6MG58-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6V6-1", "uniprot_id": [ { "id": "GP108_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6V6", "type": "external" } ], "mass": 64689.0, "length": 577, "protein_name": "Protein GPR108", "gene_name": "Gpr108", "organism": "Rat", "refseq_name": "protein GPR108 precursor", "refseq_ac": [ { "id": "NP_955431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955431", "type": "external" } ], "gene_names_uniprotkb": "Gpr108", "gene_names_refseq": "Gpr108", "protein_names_uniprotkb": "Protein GPR108", "protein_names_refseq": "protein GPR108 precursor; protein GPR108", "tax_id": 10116, "disease": "", "pathway": " (rno:316136)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in intracellular immune modulation by activating NF-kappaB response and attenuating Toll-like-receptor response., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "M0R518", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005802 trans-Golgi network;GO:0033106 cis-Golgi network membrane", "go_biological_process": "GO:0051607 defense response to virus;GO:0050776 regulation of immune response;GO:0060337 type I interferon-mediated signaling pathway;GO:0030163 protein catabolic process;GO:0034122 negative regulation of toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P6V6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P7D5-1", "uniprot_id": [ { "id": "M1IP1_RAT", "url": "https://www.uniprot.org/uniprot/Q6P7D5", "type": "external" } ], "mass": 20414.0, "length": 183, "protein_name": "Mid1-interacting protein 1", "gene_name": "Mid1ip1", "organism": "Rat", "refseq_name": "mid1-interacting protein 1", "refseq_ac": [ { "id": "NP_996833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996833", "type": "external" } ], "gene_names_uniprotkb": "Mid1ip1; Mig12", "gene_names_refseq": "Mid1ip1; Mig12; S14R; slap", "protein_names_uniprotkb": "Mid1-interacting protein 1; Gastrulation-specific G12-like protein; Mid1-interacting G12-like protein; Protein STRAIT11499 homolog; S14R; Spot 14-R; Spot 14-related protein", "protein_names_refseq": "MID1 interacting G12-like protein; MID1 interacting protein 1 (gastrulation specific G12 homolog); gastrulation-specific G12-like protein; mid1-interacting G12-like protein; mid1-interacting protein 1; protein STRAIT11499 homolog; spot 14-R; spot 14-like androgen-inducible protein; spot 14-related protein", "tax_id": 10116, "disease": "", "pathway": " (rno:404280); (R-RNO-200425)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18505691;20233797;22673903", "class_list": "", "function": "Data support the hypothesis that both S14 and S14R are directly involved in supporting hepatic lipogenesis and that the two proteins play overlapping roles in this process., [RefSeq, PubMed]; Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity)., [UniProtKB, PubMed]; Transient up-regulation of slap protein in androgen-stimulated prostate is reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0007026 negative regulation of microtubule depolymerization;GO:0045723 positive regulation of fatty acid biosynthetic process;GO:0051258 protein polymerization;GO:0046890 regulation of lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6P7D5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Q7Y5-1", "uniprot_id": [ { "id": "GNA13_RAT", "url": "https://www.uniprot.org/uniprot/Q6Q7Y5", "type": "external" } ], "mass": 44012.0, "length": 377, "protein_name": "Guanine nucleotide-binding protein subunit alpha-13", "gene_name": "Gna13", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein subunit alpha-13", "refseq_ac": [ { "id": "NP_001013137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013137", "type": "external" } ], "gene_names_uniprotkb": "Gna13", "gene_names_refseq": "Galpha13; Gna13", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit alpha-13; G alpha-13; G protein subunit alpha-13", "protein_names_refseq": "G alpha-13; guanine nucleotide binding protein (G protein), alpha 13; guanine nucleotide binding protein, alpha 13; guanine nucleotide-binding protein subunit alpha-13", "tax_id": 10116, "disease": "McCune Albright syndrome (Disease Ontology:DOID:1858)", "pathway": " (rno:303634); (R-RNO-193648); (R-RNO-416482); (R-RNO-428930); (R-RNO-9013148); (R-RNO-9013149)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "12176367;21633357;38843836", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:12176367). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (By similarity). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (By similarity). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (By similarity). In lymphoid follicles, transmits P2RY8- and S1PR2-dependent signals that lead to inhibition of germinal center (GC) B cell growth and migration outside the GC niche., [UniProtKB, PubMed, UniProtKB, UniProtKB]; It was concluded that a D3 receptor interaction with Galpha12/Galpha13 that increases sodium excretion may have a role in the regulation of blood pressure., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031752 D5 dopamine receptor binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0042470 melanosome;GO:0098794 postsynapse", "go_biological_process": "GO:0001525 angiogenesis;GO:0001701 in utero embryonic development;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6Q7Y5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6T5E0-1", "uniprot_id": [ { "id": "Q6T5E0_RAT", "url": "https://www.uniprot.org/uniprot/Q6T5E0", "type": "external" } ], "mass": 45538.0, "length": 400, "protein_name": "Glucosaminyl (N-acetyl) transferase 2", "gene_name": "Gcnt2", "organism": "Rat", "refseq_name": "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform 1", "refseq_ac": [ { "id": "NP_001387780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001387780", "type": "external" } ], "gene_names_uniprotkb": "Gcnt2", "gene_names_refseq": "Gcnt2; Gcnt6; Ignt", "protein_names_uniprotkb": "Glucosaminyl (N-acetyl) transferase 2", "protein_names_refseq": "I-branching beta-1,6-acetylglucosaminyltransferase; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform 1; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase-like; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; glucosaminyl (N-acetyl) transferase 2 (I blood group); glucosaminyl (N-acetyl) transferase 2, I-branching enzyme; glucosaminyl (N-acetyl) transferase 6", "tax_id": 10116, "disease": "cataract 13 with adult i phenotype (Disease Ontology:DOID:0110242); cataract (Disease Ontology:DOID:83)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008375 acetylglucosaminyltransferase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 2877, "hit_score": 0.1, "record_id": "Q6T5E0-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TA25-1", "uniprot_id": [ { "id": "FGOP2_RAT", "url": "https://www.uniprot.org/uniprot/Q6TA25", "type": "external" } ], "mass": 29374.0, "length": 253, "protein_name": "FGFR1 oncogene partner 2 homolog", "gene_name": "Fgfr1op2", "organism": "Rat", "refseq_name": "FGFR1 oncogene partner 2 homolog", "refseq_ac": [ { "id": "NP_958824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958824", "type": "external" } ], "gene_names_uniprotkb": "Fgfr1op2", "gene_names_refseq": "Fgfr1op2; Wit3.0", "protein_names_uniprotkb": "FGFR1 oncogene partner 2 homolog; Wit3.0; Wound-inducible transcript 3.0 protein", "protein_names_refseq": "FGFR1 oncogene partner 2 homolog; Wit3.0_alpha; Wit3.0_beta; wound inducible transcript 3.0 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:362463)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12097305;14527947;19959814", "class_list": "", "function": "Expressed by the fibroblasts associated with tooth extraction wound-healing (wit 3.0), [RefSeq, PubMed]; FGFR1OP2/wit3.0 may regulate cell motility and stimulate wound closure., [RefSeq, PubMed]; May be involved in wound healing pathway underlying the favorable early wound closure characteristics of oral mucosa. Accelerates the collagen gel contraction in vitro., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5PPH1;Q6TA26", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009611 response to wounding;GO:0042060 wound healing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6TA25-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TUG0-1", "uniprot_id": [ { "id": "DJB11_RAT", "url": "https://www.uniprot.org/uniprot/Q6TUG0", "type": "external" } ], "mass": 40495.0, "length": 358, "protein_name": "DnaJ homolog subfamily B member 11", "gene_name": "Dnajb11", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily B member 11 precursor", "refseq_ac": [ { "id": "NP_001015021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015021", "type": "external" } ], "gene_names_uniprotkb": "Dnajb11", "gene_names_refseq": "Dnajb11; LRRGT00084", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 11; ER-associated DNAJ; ER-associated Hsp40 co-chaperone; ER-resident protein ERdj3; ERdj3; ERj3p; Endoplasmic reticulum DNA J domain-containing protein 3; Liver regeneration-related protein LRRGT00084", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 11; ER-associated Hsp40 co-chaperone; ER-associated dnaJ protein 3; ER-resident protein ERdj3; ERdj3; ERj3p; dnaJ homolog subfamily B member 11 precursor; dnaJ homolog subfamily B member 11; endoplasmic reticulum DNA J domain-containing protein 3; liver regeneration-related protein LRRGT00084", "tax_id": 10116, "disease": "polycystic kidney disease 6 (Disease Ontology:DOID:0060951)", "pathway": " (rno:360734)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12475965;32203149", "class_list": "", "function": "As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Urinary ERdj3 and mesencephalic astrocyte-derived neutrophic factor identify endoplasmic reticulum stress in glomerular disease., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0051082 unfolded protein binding;GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0016556 mRNA modification;GO:0006457 protein folding;GO:0032781 positive regulation of ATP-dependent activity;GO:0050768 negative regulation of neurogenesis;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6TUG0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TXE3-1", "uniprot_id": [ { "id": "Q6TXE3_RAT", "url": "https://www.uniprot.org/uniprot/Q6TXE3", "type": "external" } ], "mass": 15979.0, "length": 145, "protein_name": "Uncharacterized protein", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6TXE3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TXG1-1", "uniprot_id": [ { "id": "Q6TXG1_RAT", "url": "https://www.uniprot.org/uniprot/Q6TXG1", "type": "external" } ], "mass": 14808.0, "length": 129, "protein_name": "Uncharacterized protein", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6TXG1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6UE39-1", "uniprot_id": [ { "id": "GLT13_RAT", "url": "https://www.uniprot.org/uniprot/Q6UE39", "type": "external" } ], "mass": 63949.0, "length": 556, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 13", "gene_name": "Galnt13", "organism": "Rat", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 13 isoform a", "refseq_ac": [ { "id": "NP_954537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954537", "type": "external" } ], "gene_names_uniprotkb": "Galnt13", "gene_names_refseq": "Galnt13; T13", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 13; 2.4.1.41; GalNAc-T13; Polypeptide GalNAc transferase 13; Protein-UDP acetylgalactosaminyltransferase 13; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13; pp-GaNTase 13", "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13); galNAc-T13; polypeptide GalNAc transferase 13; polypeptide N-acetylgalactosaminyltransferase 13 isoform a; pp-GaNTase 13; protein-UDP acetylgalactosaminyltransferase 13", "tax_id": 10116, "disease": "", "pathway": " (rno:311039); (R-RNO-913709)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine (GalNAc) residue from UDP-GalNAc to a serine or threonine residue on the protein receptor (By similarity). Generates GalNAc-O-Ser/Thr structure also known as Tn antigen, which itself is immunogenic but also serves as a precursor for the synthesis of different mucin-type O-glycan core structures (By similarity). Contributes to the synthesis of O-linked glycans on mucins and proteoglycans of the central nervous system (By similarity). Can glycosylate both unmodified peptides and glycopeptides that already contain an O-linked GalNAc sugar. Transfers GalNAc to Thr-/Ser-rich tandem repeats GTTPSPVPTTSTTSAP of MUC5AC. Transfers GalNAc to three consecutive serine/threonine residues on SDC3 forming a triplet-Tn epitope expressed in Purkinje cells of the developing brain (By similarity). May promote neurogenesis through glycosylation and stabilization of PDPN (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine", "synthesized_glycan_count": 7434, "hit_score": 0.1, "record_id": "Q6UE39-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Y290-1", "uniprot_id": [ { "id": "GOLI_RAT", "url": "https://www.uniprot.org/uniprot/Q6Y290", "type": "external" } ], "mass": 46449.0, "length": 419, "protein_name": "E3 ubiquitin-protein ligase RNF130", "gene_name": "AABR07029581.1; Rnf130", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF130 precursor", "refseq_ac": [ { "id": "NP_001032747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032747", "type": "external" } ], "gene_names_uniprotkb": "AABR07029581.1; Rnf130; AABR07029581.1; Rnf130", "gene_names_refseq": "Rnf130", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF130; 2.3.2.27; Goliath homolog; R-goliath; RING finger protein 130", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF130 precursor; E3 ubiquitin-protein ligase RNF130; R-goliath; goliath homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:652955); (R-RNO-983168)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "13679316", "class_list": "", "function": "Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells., [UniProtKB]; Acts as an E3 ubiquitin-protein ligase. May have a role during the programmed cell death of hematopoietic cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6Y290-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q712G6-1", "uniprot_id": [ { "id": "FUT7_RAT", "url": "https://www.uniprot.org/uniprot/Q712G6", "type": "external" } ], "mass": 42958.0, "length": 370, "protein_name": "Alpha-(1,3)-fucosyltransferase 7", "gene_name": "Fut7", "organism": "Rat", "refseq_name": "alpha-(1,3)-fucosyltransferase 7 isoform 2", "refseq_ac": [ { "id": "NP_955785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955785", "type": "external" } ], "gene_names_uniprotkb": "Fut7", "gene_names_refseq": "Fuc-TVII; FucT-VII; Fut7", "protein_names_uniprotkb": "Alpha-(1,3)-fucosyltransferase 7; 2.4.1.-; Fuc-TVII; FucT-VII; Fucosyltransferase 7; Fucosyltransferase VII; Galactoside 3-L-fucosyltransferase; Selectin ligand synthase", "protein_names_refseq": "alpha (1,3) fucosyltransferase; alpha-(1,3)-fucosyltransferase 7 isoform 2; alpha-(1,3)-fucosyltransferase 7; fucosyltransferase VII; galactoside 3-L-fucosyltransferase; selectin ligand synthase", "tax_id": 10116, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (rno:296564); (R-RNO-9037629)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16218937", "class_list": "", "function": "Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein or a glycolipid-linked sialopolylactosamines chain through an alpha-1,3 glycosidic linkage and participates in the final fucosylation step in the biosynthesis of the sialyl Lewis X (sLe(x)), a carbohydrate involved in cell and matrix adhesion during leukocyte trafficking and fertilization (PubMed:16218937). In vitro, also synthesizes sialyl-dimeric-Lex structures, from VIM-2 structures and both di-fucosylated and trifucosylated structures from mono-fucosylated precursors. However does not catalyze alpha 1-3 fucosylation when an internal alpha 1-3 fucosylation is present in polylactosamine chain and the fucosylation rate of the internal GlcNAc residues is reduced once fucose has been added to the distal GlcNAc. Also catalyzes the transfer of a fucose from GDP-beta-fucose to the 6-sulfated a(2,3)sialylated substrate to produce 6-sulfo sLex mediating significant L-selectin-dependent cell adhesion. Through sialyl-Lewis(x) biosynthesis, can control SELE- and SELP-mediated cell adhesion with leukocytes and allows leukocytes tethering and rolling along the endothelial tissue thereby enabling the leukocytes to accumulate at a site of inflammation. May enhance embryo implantation through sialyl Lewis X (sLeX)-mediated adhesion of embryo cells to endometrium. May affect insulin signaling by up-regulating the phosphorylation and expression of some signaling molecules involved in the insulin-signaling pathway through SLe(x) which is present on the glycans of the INSRR alpha subunit (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.152", "type": "external" } ], "go_molecular_function": "GO:0008417 fucosyltransferase activity;GO:0046920 alpha-(1->3)-fucosyltransferase activity;GO:0017083 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0002522 leukocyte migration involved in immune response;GO:1903238 positive regulation of leukocyte tethering or rolling;GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell", "synthesized_glycan_count": 556, "hit_score": 0.2, "record_id": "Q712G6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76MX4-1", "uniprot_id": [ { "id": "MAFG_RAT", "url": "https://www.uniprot.org/uniprot/Q76MX4", "type": "external" } ], "mass": 20533.0, "length": 189, "protein_name": "Transcription factor MafG", "gene_name": "Mafg", "organism": "Rat", "refseq_name": "transcription factor MafG", "refseq_ac": [ { "id": "NP_071781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071781", "type": "external" } ], "gene_names_uniprotkb": "Mafg", "gene_names_refseq": "Mafg", "protein_names_uniprotkb": "Transcription factor MafG; V-maf musculoaponeurotic fibrosarcoma oncogene homolog G", "protein_names_refseq": "transcription factor MafG; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G", "tax_id": 10116, "disease": "", "pathway": " (rno:64188); (R-RNO-983231)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10724342;11583919;15828020;17928287", "class_list": "", "function": "MafG-FBJ osteosarcoma oncogene B complexes are involved in transcriptional regulation in response to extracellular acidification, [RefSeq, PubMed]; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (By similarity). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (By similarity). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (By similarity). Transcription factor, component of erythroid-specific transcription factor NFE2L2 (By similarity). Activates globin gene expression when associated with NFE2L2 (By similarity). May be involved in signal transduction of extracellular H(+) (PubMed:11583919)., [UniProtKB, UniProtKB, PubMed]; The up-regulation of TCF11/MafG binding could be suppressed by overexpression of the TGF-beta inhibitor Smad7, and a small interfering RNA to TCF11 blocked the suppression of iNOS by TGF-beta., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99N83", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0045604 regulation of epidermal cell differentiation;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q76MX4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78E65-1", "uniprot_id": [ { "id": "JDP2_RAT", "url": "https://www.uniprot.org/uniprot/Q78E65", "type": "external" } ], "mass": 18675.0, "length": 163, "protein_name": "Jun dimerization protein 2", "gene_name": "Jdp2", "organism": "Rat", "refseq_name": "jun dimerization protein 2", "refseq_ac": [ { "id": "NP_446346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446346", "type": "external" } ], "gene_names_uniprotkb": "Jdp2; Jdp-2; Jundm2; Jundp2", "gene_names_refseq": "Jdp2; Jundm2; Jundp2", "protein_names_uniprotkb": "Jun dimerization protein 2", "protein_names_refseq": "jun dimerization protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:116674)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16199860;33676985;9154808;9778531", "class_list": "", "function": "Candidate plasticity gene 16 and jun dimerization protein 2 are involved in the suppression of insulin gene expression in rat pancreatic INS-1 beta-cells., [RefSeq, PubMed]; Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1, such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin (By similarity)., [UniProtKB, PubMed]; JDP-2 enhances transcriptional activity of progesterone receptor through a protein folding mechanism by an interdomain communication., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045599 negative regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q78E65-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M0E3-1", "uniprot_id": [ { "id": "DEST_RAT", "url": "https://www.uniprot.org/uniprot/Q7M0E3", "type": "external" } ], "mass": 18534.0, "length": 165, "protein_name": "Destrin", "gene_name": "Dstn", "organism": "Rat", "refseq_name": "destrin", "refseq_ac": [ { "id": "NP_001028838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028838", "type": "external" } ], "gene_names_uniprotkb": "Dstn", "gene_names_refseq": "Dstn", "protein_names_uniprotkb": "Destrin; ADF; Actin-depolymerizing factor", "protein_names_refseq": "ADF; actin-depolymerizing factor; destrin", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); nemaline myopathy 7 (Disease Ontology:DOID:0110934); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:502674)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12947022;18171679;22673903;24093776;31400829;34502162;9877327", "class_list": "", "function": "Actin depolymerizing factor (ADF)/cofilin controls actin turnover to sustain axon regeneration after spinal cord injury through its actin-severing activity. This pinpoints ADF/cofilin as a key regulator of axon growth competence, irrespective of developmental stage., [RefSeq, PubMed]; Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner., [UniProtKB, UniProtKB, UniProtKB]; Although ADF and cofilin-1 have many redundant functions, each of these proteins has functional differences that affect F-actin structures, cell adhesion and lamellipodial dynamics, all of which are important determinants of cell migration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0098794 postsynapse;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0048870 cell motility;GO:0051014 actin filament severing;GO:0030042 actin filament depolymerization;GO:0030043 actin filament fragmentation;GO:0030836 positive regulation of actin filament depolymerization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7M0E3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TN38-1", "uniprot_id": [ { "id": "MRGRH_RAT", "url": "https://www.uniprot.org/uniprot/Q7TN38", "type": "external" } ], "mass": 36780.0, "length": 321, "protein_name": "Mas-related G protein-coupled receptor member H", "gene_name": "Mas1l; Mrgprh", "organism": "Rat", "refseq_name": "mas-related G-protein coupled receptor member H", "refseq_ac": [ { "id": "NP_001002281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002281", "type": "external" } ], "gene_names_uniprotkb": "Mas1l; Mrgprh; Mrgh", "gene_names_refseq": "Mas1l; Mgrb; MrgHGPR90; Mrgprh", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member H", "protein_names_refseq": "MAS-related G-protein coupled receptor, member H; MAS-related GPR, member H; MAS-related gene H; Mas-related G protein-coupled receptor b; mas-related G-protein coupled receptor member H", "tax_id": 10116, "disease": "", "pathway": " (rno:404641)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12909716", "class_list": "", "function": "Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0001595 angiotensin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TN38-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQ72-1", "uniprot_id": [ { "id": "MIS12_RAT", "url": "https://www.uniprot.org/uniprot/Q7TQ72", "type": "external" } ], "mass": 24161.0, "length": 206, "protein_name": "Protein MIS12 homolog", "gene_name": "Mis12", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mis12; Ac1585", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein MIS12 homolog; Liver regeneration-related protein LRRG112", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:501706); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore;GO:0000940 outer kinetochore;GO:0000444 MIS12/MIND type complex", "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051382 kinetochore assembly;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0000070 mitotic sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TQ72-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQN7-1", "uniprot_id": [ { "id": "GP135_RAT", "url": "https://www.uniprot.org/uniprot/Q7TQN7", "type": "external" } ], "mass": 49581.0, "length": 457, "protein_name": "G protein-coupled receptor 135", "gene_name": "Gpr135", "organism": "Rat", "refseq_name": "G-protein coupled receptor 135", "refseq_ac": [ { "id": "NP_861436", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861436", "type": "external" } ], "gene_names_uniprotkb": "Gpr135", "gene_names_refseq": "Gpr135", "protein_names_uniprotkb": "G protein-coupled receptor 135", "protein_names_refseq": "G-protein coupled receptor 135; probable G-protein coupled receptor 135", "tax_id": 10116, "disease": "", "pathway": " (rno:314213)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14623098;31038027", "class_list": "", "function": "Orphan receptor. Has spontaneous activity for beta-arrestin recruitment. Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity)., [UniProtKB, UniProtKB]; We conclude that the orphan receptor GPR135 is expressed in different tissues and its expression tends to be modified due to diabetes, besides that it is functional and that it seems to be coupled to Gi/o protein which has negative chronotropic and inotropic effects, therefore, we do not rule out that it participates in the cardiovascular complications associated with diabetes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:1990763 arrestin family protein binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TQN7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQN8-1", "uniprot_id": [ { "id": "GP119_RAT", "url": "https://www.uniprot.org/uniprot/Q7TQN8", "type": "external" } ], "mass": 51686.0, "length": 468, "protein_name": "Glucose-dependent insulinotropic receptor", "gene_name": "Gpr119", "organism": "Rat", "refseq_name": "glucose-dependent insulinotropic receptor", "refseq_ac": [ { "id": "NP_861435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861435", "type": "external" } ], "gene_names_uniprotkb": "Gpr119", "gene_names_refseq": "Gpr119", "protein_names_uniprotkb": "Glucose-dependent insulinotropic receptor; G protein-coupled receptor 119", "protein_names_refseq": "glucose-dependent insulinotropic receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:302813); (R-RNO-381771); (R-RNO-400511)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "14623098;15607732;17289847;23069642;24451185;25578601;27391814;27581068", "class_list": "", "function": "Angelica dahurica extract-treated cells showed significant increases in GPR119 activation, intracellular cAMP levels, GLP-1 levels and glucose-stimulated insulin secretion as compared with controls Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that GPR119 activation/up-regulation in skeletal muscle impairs fatty acid and glucose oxidation; diet-induced obesity appears to up-regulate skeletal muscle GPR119., [RefSeq, PubMed]; Pathways activated in response to GPR119 modulation in cardiac muscle cells differ between healthy and metabolically dysregulated states., [RefSeq, PubMed]; Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway., [UniProtKB, PubMed]; Results show that functional GPR119 responses are similar in lean and diabetic rodent, and human colon; that GPR119 stimulation can result in glucose lowering through release of intestinal peptide hormones., [RefSeq, PubMed]; The results demonstrate that the neural coordination between the the gustatory and gastrointestinal insula is generated or suppressed by the opposing activities between CB1R and GPR119. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0031210 phosphatidylcholine binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0030073 insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TQN8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSA0-1", "uniprot_id": [ { "id": "MIRO2_RAT", "url": "https://www.uniprot.org/uniprot/Q7TSA0", "type": "external" } ], "mass": 69153.0, "length": 622, "protein_name": "Mitochondrial Rho GTPase 2", "gene_name": "Rhot2", "organism": "Rat", "refseq_name": "mitochondrial Rho GTPase 2", "refseq_ac": [ { "id": "NP_861544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_861544", "type": "external" } ], "gene_names_uniprotkb": "Rhot2; Arht2", "gene_names_refseq": "Miro2; Rhot2", "protein_names_uniprotkb": "Mitochondrial Rho GTPase 2; 3.6.5.-; MIRO-2; Ras homolog gene family member T2", "protein_names_refseq": "MIRO-2; mitochondrial Rho GTPase 2; ras homolog gene family, member T2", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:287156); (R-RNO-9013419)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15218247;19098100;24995978", "class_list": "", "function": "Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. Can hydrolyze GTP, ATP and UTP (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Miro proteins serve as a [Ca(2+)](c)-sensitive switch and bifunctional regulator for both the motility and fusion-fission dynamics of the mitochondria., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0016887 ATP hydrolysis activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0047497 mitochondrion transport along microtubule;GO:0019725 cellular homeostasis;GO:0007005 mitochondrion organization;GO:0097345 mitochondrial outer membrane permeabilization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TSA0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSN5-1", "uniprot_id": [ { "id": "GP151_RAT", "url": "https://www.uniprot.org/uniprot/Q7TSN5", "type": "external" } ], "mass": 46724.0, "length": 421, "protein_name": "Probable G protein-coupled receptor 151", "gene_name": "Gpr151", "organism": "Rat", "refseq_name": "probable G-protein coupled receptor 151", "refseq_ac": [ { "id": "NP_853664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_853664", "type": "external" } ], "gene_names_uniprotkb": "Gpr151", "gene_names_refseq": "Gpr151; nGPCR-2037", "protein_names_uniprotkb": "Probable G protein-coupled receptor 151; GPCR-2037", "protein_names_refseq": "GPCR-2037; probable G-protein coupled receptor 151; putative G protein-coupled receptor nGPCR-2037", "tax_id": 10116, "disease": "", "pathway": " (rno:307475)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14667573;25116430", "class_list": "", "function": "Orphan receptor., [UniProtKB]; This study demonstrated that GPR151 expression in the rats brain is restricted to habenular neurons projecting to the interpeduncular nucleus,Rostromedial tegmental nucleus, rhabdoid nucleus, mesencephalic raphe nuclei, and dorsal tegmental nucleus., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030672 synaptic vesicle membrane;GO:0042734 presynaptic membrane;GO:0098981 cholinergic synapse", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0010447 response to acidic pH;GO:2000300 regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TSN5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Z39-1", "uniprot_id": [ { "id": "HCAR2_RAT", "url": "https://www.uniprot.org/uniprot/Q80Z39", "type": "external" } ], "mass": 41459.0, "length": 360, "protein_name": "Hydroxycarboxylic acid receptor 2", "gene_name": "Hcar2", "organism": "Rat", "refseq_name": "hydroxycarboxylic acid receptor 2", "refseq_ac": [ { "id": "NP_852141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852141", "type": "external" } ], "gene_names_uniprotkb": "Hcar2; Gpr109a; Gpr109b; Gpr109; Niacr1; Pumag", "gene_names_refseq": "Gpr109a; Gpr109b; Hcar2; Hm74b; Hm74; Niacr1; Pumag; rHM74b", "protein_names_uniprotkb": "Hydroxycarboxylic acid receptor 2; G protein-coupled receptor 109A; G protein-coupled receptor 109; G protein-coupled receptor HM74; Niacin receptor 1; Nicotinic acid receptor; Protein PUMA-G", "protein_names_refseq": "G protein-coupled receptor 109B; G protein-coupled receptor Hm74b; G-protein coupled receptor 109A; G-protein coupled receptor HM74; hydroxycarboxylic acid receptor 2; interferon-gamma inducible gene, Puma-g; niacin receptor 1; nicotinic acid receptor; protein PUMA-G", "tax_id": 10116, "disease": "", "pathway": " (rno:353250); (R-RNO-3296197); (R-RNO-373076); (R-RNO-418594)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "12522134;12646212;19141678;25622782;29393594;36796675", "class_list": "", "function": "Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide., [UniProtKB, PubMed, PubMed, PubMed]; Data indicate that GPR109a modulates niacin-induced pancreatic islet dysfunction through activation of the islet beta-cells., [RefSeq, PubMed]; HM74b has high similarity to HM74 is a receptor for nicotinic acid, [RefSeq, PubMed]; Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology: A possible cross-talk with C-X-C chemokine receptor 1 (CXCR1). Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0001614 purinergic nucleotide receptor activity;GO:0070553 nicotinic acid receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0050995 negative regulation of lipid catabolic process;GO:0033031 positive regulation of neutrophil apoptotic process;GO:0001781 neutrophil apoptotic process;GO:0070165 positive regulation of adiponectin secretion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80Z39-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFC9-1", "uniprot_id": [ { "id": "LZTS1_RAT", "url": "https://www.uniprot.org/uniprot/Q8CFC9", "type": "external" } ], "mass": 67565.0, "length": 601, "protein_name": "Leucine zipper putative tumor suppressor 1", "gene_name": "Lzts1", "organism": "Rat", "refseq_name": "leucine zipper putative tumor suppressor 1", "refseq_ac": [ { "id": "NP_703200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_703200", "type": "external" } ], "gene_names_uniprotkb": "Lzts1", "gene_names_refseq": "Lzts1; Psdzip70", "protein_names_uniprotkb": "Leucine zipper putative tumor suppressor 1; PSD-Zip70", "protein_names_refseq": "PSD-Zip70; leucine zipper putative tumor suppressor 1; leucine zipper, putative tumor suppressor 1", "tax_id": 10116, "disease": "squamous cell carcinoma (Disease Ontology:DOID:1749); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); esophageal cancer (Disease Ontology:DOID:5041)", "pathway": " (rno:266711)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12415013;15703396", "class_list": "", "function": "Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as tumor suppressor (By similarity)., [UniProtKB]; PSD-Zip70 in collaboration with SPAR is critically involved in spine maturity, especially in the mature spine formation and the maintenance of spine maturity., [RefSeq, PubMed]; Postsynaptic density and dendritic raft localization of PSD-Zip70, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0043197 dendritic spine;GO:0043198 dendritic shaft;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0048814 regulation of dendrite morphogenesis;GO:0048167 regulation of synaptic plasticity;GO:0016242 negative regulation of macroautophagy;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CFC9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFD9-1", "uniprot_id": [ { "id": "NCTR3_RAT", "url": "https://www.uniprot.org/uniprot/Q8CFD9", "type": "external" } ], "mass": 20470.0, "length": 192, "protein_name": "Natural cytotoxicity triggering receptor 3", "gene_name": "Ncr3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ncr3; 1c7", "gene_names_refseq": "", "protein_names_uniprotkb": "Natural cytotoxicity triggering receptor 3; NK-p30; NKp30; Natural killer cell p30-related protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "malaria (Disease Ontology:DOID:12365); hepatitis C (Disease Ontology:DOID:1883); acquired immunodeficiency syndrome (Disease Ontology:DOID:635)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "12180816;12548565;15060004", "class_list": "", "function": "Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG that promote DC maturation., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80WM8;Q8CG11", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0140375 immune receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0045954 positive regulation of natural killer cell mediated cytotoxicity;GO:0002429 immune response-activating cell surface receptor signaling pathway;GO:0030101 natural killer cell activation;GO:0051132 NK T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CFD9-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CH87-1", "uniprot_id": [ { "id": "GCNT3_RAT", "url": "https://www.uniprot.org/uniprot/Q8CH87", "type": "external" } ], "mass": 50642.0, "length": 437, "protein_name": "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3", "gene_name": "Gcnt3", "organism": "Rat", "refseq_name": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3", "refseq_ac": [ { "id": "NP_775434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775434", "type": "external" } ], "gene_names_uniprotkb": "Gcnt3", "gene_names_refseq": "C2GnT-M; Gcnt3; dI/C2/C4GnT; dIGnT", "protein_names_uniprotkb": "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3; 2.4.1.102; 2.4.1.148; 2.4.1.150; C2GnT-M; C2GnT-mucin type; dI/C2/C4GnT; dIGnT", "protein_names_refseq": "C2GnT-mucin type; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3; beta-1,6-N-acetylglucosaminyltransferase; beta-16-N-acetylglucosaminyltransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:286976); (R-RNO-913709)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12626393", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Also has I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development., [UniProtKB]; Purification, cloning and sequencing of enzyme from small intestine; significant homology with human and virus enzyme, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.102", "type": "external" }, { "id": "2.4.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.150", "type": "external" }, { "id": "2.4.1.148", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.148", "type": "external" } ], "go_molecular_function": "GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity;GO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008375 acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0048729 tissue morphogenesis;GO:0060993 kidney morphogenesis;GO:0050892 intestinal absorption", "synthesized_glycan_count": 2877, "hit_score": 0.2, "record_id": "Q8CH87-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHM6-1", "uniprot_id": [ { "id": "Q8CHM6_RAT", "url": "https://www.uniprot.org/uniprot/Q8CHM6", "type": "external" } ], "mass": 34450.0, "length": 295, "protein_name": "Ankyrin repeat and SOCS box protein 17", "gene_name": "Asb17", "organism": "Rat", "refseq_name": "ankyrin repeat and SOCS box protein 17", "refseq_ac": [ { "id": "NP_001103146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103146", "type": "external" } ], "gene_names_uniprotkb": "Asb17", "gene_names_refseq": "Asb17; asb-17", "protein_names_uniprotkb": "Ankyrin repeat and SOCS box protein 17", "protein_names_refseq": "ankyrin repeat and SOCS box containing protein 17; ankyrin repeat and SOCS box protein 17", "tax_id": 10116, "disease": "", "pathway": " (rno:687364); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0061831 apical ectoplasmic specialization", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CHM6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4J7-1", "uniprot_id": [ { "id": "Q8K4J7_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4J7", "type": "external" } ], "mass": 12293.0, "length": 114, "protein_name": "Resistin", "gene_name": "Retn", "organism": "Rat", "refseq_name": "resistin precursor", "refseq_ac": [ { "id": "NP_653342", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653342", "type": "external" } ], "gene_names_uniprotkb": "Retn", "gene_names_refseq": "Retn", "protein_names_uniprotkb": "Resistin", "protein_names_refseq": "resistin precursor", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); COVID-19 (Disease Ontology:DOID:0080600); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); heart disease (Disease Ontology:DOID:114); pyelonephritis (Disease Ontology:DOID:11400); gestational diabetes (Disease Ontology:DOID:11714); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); uremia (Disease Ontology:DOID:4676); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:246250); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12021211;12387885;30612469;31053755;31085594;32410876", "class_list": "", "function": "Investigation of role in inflammatory processes and induction by inflammatory stimuli, [RefSeq, PubMed]; Relation between resistin, PPAR-gamma, obesity and atherosclerosis in male albino rats., [RefSeq, PubMed]; Resistin Is Increased in Periodontal Cells and Tissues: In Vitro and In Vivo Studies. Publication Status: Online-Only, [RefSeq, PubMed]; Resistin Mediates Sex-Dependent Effects of Perivascular Adipose Tissue on Vascular Function in the Shrsp. Publication Status: Online-Only, [RefSeq, PubMed]; Significant correlations were observed between PGC-1alpha gene expression and serum concentrations of irisin, nesfatin-1 and resistin. beta-hydroxy-beta-methylbutyrate free acid supplementation with eccentric resistance training may induce crosstalk between peptide release from other tissues and increases maximal muscle strength. The combination of the two interventions had a more substantial effect than each in isolat... Publication Status: Online-Only, [RefSeq, PubMed]; Unexpected, marked, rapid and sustained up-regulation of resistin by Growth Hormone indicated a role for resistin in GH-dependent metabolic and differentiative effects in white adipose tissue., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:2000252 negative regulation of feeding behavior;GO:0009612 response to mechanical stimulus;GO:0032868 response to insulin;GO:0045444 fat cell differentiation;GO:2000872 positive regulation of progesterone secretion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K4J7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5L7-1", "uniprot_id": [ { "id": "FGF14_RAT", "url": "https://www.uniprot.org/uniprot/Q8R5L7", "type": "external" } ], "mass": 27720.0, "length": 247, "protein_name": "Fibroblast growth factor 14", "gene_name": "Fgf14", "organism": "Rat", "refseq_name": "fibroblast growth factor 14 isoform 1", "refseq_ac": [ { "id": "NP_071559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071559", "type": "external" } ], "gene_names_uniprotkb": "Fgf14", "gene_names_refseq": "FGF-14; Fgf14; Fhf4", "protein_names_uniprotkb": "Fibroblast growth factor 14; FGF-14", "protein_names_refseq": "FGF homologus factor 4b; fibroblast growth factor 14 isoform 1; fibroblast growth factor homologous factor 4", "tax_id": 10116, "disease": "spinocerebellar ataxia 27A (Disease Ontology:DOID:0050976); spinocerebellar ataxia 27B (Disease Ontology:DOID:0061137)", "pathway": " (rno:63851)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23640885;23831029;25659151;33651884", "class_list": "", "function": "FGF14 regulates presynaptic Ca2+ channels in granule cell and EPSCs in Purkinje cells., [RefSeq, PubMed]; Identified the PI3K/Akt pathway, the cell-cycle regulator Wee1 kinase, and protein kinase C (PKC) as prospective regulatory nodes of neuronal excitability through modulation of the FGF14:Nav1.6 complex. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of GSK3 reduces the assembly of the FGF14.Nav channel complex, modifies FGF14-dependent regulation of Na(+) currents, and induces dissociation and subcellular redistribution of the native FGF14.Nav channel complex in hippocampal neurons., [RefSeq, PubMed]; Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells., [RefSeq, PubMed]; Probably involved in nervous system development and function., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0017080 sodium channel regulator activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0050905 neuromuscular process;GO:0007254 JNK cascade;GO:0007268 chemical synaptic transmission;GO:0048167 regulation of synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R5L7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VI82-1", "uniprot_id": [ { "id": "FGF23_RAT", "url": "https://www.uniprot.org/uniprot/Q8VI82", "type": "external" } ], "mass": 27912.0, "length": 251, "protein_name": "Fibroblast growth factor 23", "gene_name": "Fgf23", "organism": "Rat", "refseq_name": "fibroblast growth factor 23 precursor", "refseq_ac": [ { "id": "NP_570110", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570110", "type": "external" } ], "gene_names_uniprotkb": "Fgf23", "gene_names_refseq": "Fgf23; Fgf8b", "protein_names_uniprotkb": "Fibroblast growth factor 23; FGF-23", "protein_names_refseq": "FGF-23; fibroblast growth factor 23 precursor; fibroblast growth factor 8b", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); autosomal dominant hypophosphatemic rickets (Disease Ontology:DOID:0050948); uremia (Disease Ontology:DOID:4676); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (rno:170583); (R-RNO-109704); (R-RNO-1257604); (R-RNO-190322); (R-RNO-190372); (R-RNO-190373); (R-RNO-190374); (R-RNO-190375); (R-RNO-381426); (R-RNO-5654219); (R-RNO-5654221); (R-RNO-5654227); (R-RNO-5654228); (R-RNO-5654687); (R-RNO-5654688); (R-RNO-5654689); (R-RNO-5654693); (R-RNO-5654695); (R-RNO-5654699); (R-RNO-5654700); (R-RNO-5654704); (R-RNO-5654706); (R-RNO-5654710); (R-RNO-5654712); (R-RNO-5654719); (R-RNO-5654720); (R-RNO-5654726); (R-RNO-5654727); (R-RNO-5654732); (R-RNO-5654733); (R-RNO-5658623); (R-RNO-5673001); (R-RNO-6811558); (R-RNO-8957275)", "pathway_count": 34, "publication_count": 7, "publication_id_list": "17086194;17992255;36102251;37704925;37814911;37992803;38134554", "class_list": "", "function": "Changes of FGF23 and hearing in chronic renal failure and their correlation analysis., [RefSeq, PubMed]; ENPP1 downregulation and FGF23 upregulation in growth-related calcification of the tibial tuberosity in rats., [RefSeq, PubMed]; Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation., [RefSeq, PubMed]; Intact Fibroblast Growth Factor 23 Regulates Chronic Kidney Disease-Induced Myocardial Fibrosis by Activating the Sonic Hedgehog Signaling Pathway., [RefSeq, PubMed]; Klotho/FGF23 Axis Regulates Cardiomyocyte Apoptosis and Cytokine Release through ERK/MAPK Pathway., [RefSeq, PubMed]; Regulator of phosphate homeostasis (By similarity). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity). Regulator of vitamin-D metabolism (By similarity). Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity). Acts directly on the parathyroid to decrease PTH secretion (PubMed:17992255). Up-regulates EGR1 expression in the presence of KL (PubMed:17086194)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005105 type 1 fibroblast growth factor receptor binding;GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0042359 vitamin D metabolic process;GO:0042369 vitamin D catabolic process;GO:0010966 regulation of phosphate transport;GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;GO:1904383 response to sodium phosphate", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VI82-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XQ4-1", "uniprot_id": [ { "id": "GRL1A_RAT", "url": "https://www.uniprot.org/uniprot/Q91XQ4", "type": "external" } ], "mass": 40874.0, "length": 364, "protein_name": "DNA-directed RNA polymerase II subunit GRINL1A", "gene_name": "Polr2m", "organism": "Rat", "refseq_name": "DNA-directed RNA polymerase II subunit GRINL1A", "refseq_ac": [ { "id": "NP_899652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899652", "type": "external" } ], "gene_names_uniprotkb": "Polr2m; Grinl1a", "gene_names_refseq": "Glurr; Grinl1a; Polr2m", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit GRINL1A; DNA-directed RNA polymerase II subunit M; Glutamate receptor-like protein 1A", "protein_names_refseq": "DNA-directed RNA polymerase II subunit GRINL1A; DNA-directed RNA polymerase II subunit M; glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A; glutamate receptor-like protein 1A; polymerase (RNA) II (DNA directed) polypeptide M; polymerase (RNA) II subunit M; protein GRINL1A", "tax_id": 10116, "disease": "", "pathway": " (rno:192147)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11474202", "class_list": "", "function": "Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000993 RNA polymerase II complex binding;GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0043025 neuronal cell body;GO:0031674 I band", "go_biological_process": "GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0051685 maintenance of ER location", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91XQ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920P0-1", "uniprot_id": [ { "id": "DCXR_RAT", "url": "https://www.uniprot.org/uniprot/Q920P0", "type": "external" } ], "mass": 25720.0, "length": 244, "protein_name": "L-xylulose reductase", "gene_name": "Dcxr", "organism": "Rat", "refseq_name": "L-xylulose reductase", "refseq_ac": [ { "id": "NP_599214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599214", "type": "external" } ], "gene_names_uniprotkb": "Dcxr; Glb", "gene_names_refseq": "Dcxr; glb", "protein_names_uniprotkb": "L-xylulose reductase; 1.1.1.10; DCXR; Dicarbonyl/L-xylulose reductase; XR", "protein_names_refseq": "L-xylulose reductase; XR; diacetyl/L-xylulose reductase; dicarbonyl L-xylulose reductase", "tax_id": 10116, "disease": "", "pathway": " (rno:171408); (R-RNO-5661270)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11882650;12604240;15906319", "class_list": "", "function": "Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose (PubMed:11882650, PubMed:12604240). Can use both NAD and NADP as cosubstrate but shows higher activity with NADP (PubMed:11882650). Participates in the uronate cycle of glucose metabolism (PubMed:11882650). May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules (PubMed:11882650)., [UniProtKB, PubMed, PubMed]; Dcxr is highly expressed in kidney and liver (dicarbonyl/L-xylulose reductase), [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.10", "type": "external" } ], "go_molecular_function": "GO:0050038 L-xylulose reductase (NADPH) activity;GO:0016614 oxidoreductase activity, acting on CH-OH group of donors;GO:0042802 identical protein binding;GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0004090 carbonyl reductase (NADPH) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005903 brush border;GO:0016324 apical plasma membrane;GO:0001669 acrosomal vesicle;GO:0005902 microvillus", "go_biological_process": "GO:0005997 xylulose metabolic process;GO:0006739 NADP+ metabolic process;GO:0042732 D-xylose metabolic process;GO:0006006 glucose metabolic process;GO:2000379 positive regulation of reactive oxygen species metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q920P0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921A2-1", "uniprot_id": [ { "id": "MYCT_RAT", "url": "https://www.uniprot.org/uniprot/Q921A2", "type": "external" } ], "mass": 69149.0, "length": 637, "protein_name": "Proton myo-inositol cotransporter", "gene_name": "Slc2a13", "organism": "Rat", "refseq_name": "proton myo-inositol cotransporter", "refseq_ac": [ { "id": "NP_598295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598295", "type": "external" } ], "gene_names_uniprotkb": "Slc2a13", "gene_names_refseq": "Hmit; Slc2a13", "protein_names_uniprotkb": "Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter; H(+)-myo-inositol symporter; Hmit; Solute carrier family 2 member 13", "protein_names_refseq": "h(+)-myo-inositol cotransporter; h(+)-myo-inositol symporter; proton myo-inositol cotransporter; proton myo-inositol symporter; solute carrier family 2 (facilitated glucose transporter), member 13", "tax_id": 10116, "disease": "", "pathway": " (rno:171147); (R-RNO-429593)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11500374;14749729;19607714;22673903;29551423", "class_list": "", "function": "H(+)-myo-inositol cotransporter (PubMed:11500374). Can also transport related stereoisomers (PubMed:11500374)., [UniProtKB, PubMed]; HMIT is expressed in a vesicular compartment involved in activity-dependent regulation of myo-inositol uptake in neurons, [RefSeq, PubMed]; HMIT is primarily a neuronal transporter widely expressed in the rat and human brain, with particularly high levels in the hippocampus and cortex, as shown by immunohistochemistry. Publication Status: Online-Only, [RefSeq, PubMed]; Results indicate that H(+)/myo-inositol cotransporter (HMIT) is expressed in marginal cells and basal cells of the stria vascularis, while Na(+)/myo-inositol cotransporter 1 (SMIT1) expression is enriched in basal cells. Study speculates that HMIT and SMIT1 may play important roles in the homeostasis of cochlear fluids., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0051117 ATPase binding;GO:0005366 myo-inositol:proton symporter activity;GO:0005365 myo-inositol transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030426 growth cone", "go_biological_process": "GO:0055085 transmembrane transport;GO:1902004 positive regulation of amyloid-beta formation;GO:0015798 myo-inositol transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q921A2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923V4-1", "uniprot_id": [ { "id": "FBX6_RAT", "url": "https://www.uniprot.org/uniprot/Q923V4", "type": "external" } ], "mass": 32786.0, "length": 284, "protein_name": "F-box only protein 6", "gene_name": "Fbxo6", "organism": "Rat", "refseq_name": "F-box only protein 6", "refseq_ac": [ { "id": "NP_620272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620272", "type": "external" } ], "gene_names_uniprotkb": "Fbxo6; Fbg2; Fbs2; Fbxo6b", "gene_names_refseq": "Fbg2; Fbxo6b; Fbxo6", "protein_names_uniprotkb": "F-box only protein 6; F-box only protein 6b; F-box protein that recognizes sugar chains 2; F-box/G-domain protein 2", "protein_names_refseq": "F-box only protein 6 b; F-box only protein 6b; F-box only protein 6; F-box protein that recognizes sugar chains 2; F-box/G-domain protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:192351); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12383498;22673903;29393594", "class_list": "", "function": "Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to ensure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P512", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex;GO:0044322 endoplasmic reticulum quality control compartment", "go_biological_process": "GO:0006281 DNA repair;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q923V4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923W4-1", "uniprot_id": [ { "id": "HDGR3_RAT", "url": "https://www.uniprot.org/uniprot/Q923W4", "type": "external" } ], "mass": 22447.0, "length": 202, "protein_name": "Hepatoma-derived growth factor-related protein 3", "gene_name": "Hdgfl3", "organism": "Rat", "refseq_name": "hepatoma-derived growth factor-related protein 3", "refseq_ac": [ { "id": "NP_665728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665728", "type": "external" } ], "gene_names_uniprotkb": "Hdgfl3; Hdgfrp3; Hrp3", "gene_names_refseq": "Hdgfl3; Hdgfrp3", "protein_names_uniprotkb": "Hepatoma-derived growth factor-related protein 3; HRP-3", "protein_names_refseq": "HRP-3; hepatoma-derived growth factor, related protein 3; hepatoma-derived growth factor-related protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:252941)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16430771;22673903;29393594;32647008", "class_list": "", "function": "Enhances DNA synthesis and may play a role in cell proliferation., [UniProtKB]; HRP-3 was expressed in the bulbus olfactorius, piriform cortex and amygdala complex. Expression was mainly in neurons and some brain stem oligodendrocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008083 growth factor activity;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0031175 neuron projection development;GO:0007026 negative regulation of microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q923W4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925R7-1", "uniprot_id": [ { "id": "GLT10_RAT", "url": "https://www.uniprot.org/uniprot/Q925R7", "type": "external" } ], "mass": 69117.0, "length": 603, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 10", "gene_name": "Galnt10", "organism": "Rat", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 10", "refseq_ac": [ { "id": "NP_570098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570098", "type": "external" } ], "gene_names_uniprotkb": "Galnt10", "gene_names_refseq": "Galnt10; Galnt9", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 10; 2.4.1.41; GalNAc-T10; Polypeptide GalNAc transferase 10; Protein-UDP acetylgalactosaminyltransferase 10; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10; pp-GaNTase 10", "protein_names_refseq": "GalNAc-T9; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10; UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 9; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10); galNAc-T10; polypeptide GalNAc transferase 10; polypeptide N-acetylgalactosaminyltransferase 10; pp-GaNTase 10; protein-UDP acetylgalactosaminyltransferase 10", "tax_id": 10116, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:170501); (R-RNO-913709)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11278534;29393594", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine", "synthesized_glycan_count": 7434, "hit_score": 0.3, "record_id": "Q925R7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925T0-1", "uniprot_id": [ { "id": "DJC12_RAT", "url": "https://www.uniprot.org/uniprot/Q925T0", "type": "external" } ], "mass": 22978.0, "length": 198, "protein_name": "DnaJ homolog subfamily C member 12", "gene_name": "Dnajc12", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily C member 12", "refseq_ac": [ { "id": "NP_001029204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029204", "type": "external" } ], "gene_names_uniprotkb": "Dnajc12; Jdp1", "gene_names_refseq": "Dnajc12; Jdp1", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 12; J domain-containing protein 1", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 12; J domain protein 1; dnaJ homolog subfamily C member 12; j domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:619393)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10760603", "class_list": "", "function": "Probable co-chaperone that participates in the proper folding of biopterin-dependent aromatic amino acid hydroxylases, which include phenylalanine-4-hydroxylase (PAH), tyrosine 3-monooxygenase (TH) and peripheral and neuronal tryptophan hydroxylases (TPH1 and TPH2)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q498U2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q925T0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99P96-1", "uniprot_id": [ { "id": "HDAC7_RAT", "url": "https://www.uniprot.org/uniprot/Q99P96", "type": "external" } ], "mass": 26101.0, "length": 238, "protein_name": "Histone deacetylase 7", "gene_name": "Hdac7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hdac7; Hdac7a", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone deacetylase 7; 3.5.1.-; 3.5.1.98; HD7a; HD7; Histone deacetylase 7A; Protein deacetylase HDAC7", "protein_names_refseq": "", "tax_id": 10116, "disease": "colorectal cancer (Disease Ontology:DOID:9256); alopecia areata (Disease Ontology:DOID:986)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.5.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.48", "type": "external" }, { "id": "3.5.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.62", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0019901 protein kinase binding;GO:0003714 transcription corepressor activity;GO:0005080 protein kinase C binding;GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000118 histone deacetylase complex;GO:0005829 cytosol", "go_biological_process": "GO:0032703 negative regulation of interleukin-2 production;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001570 vasculogenesis;GO:0006351 DNA-templated transcription;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99P96-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPJ1-1", "uniprot_id": [ { "id": "Q9EPJ1_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPJ1", "type": "external" } ], "mass": 21027.0, "length": 203, "protein_name": "Twist-related protein 1", "gene_name": "Twist1", "organism": "Rat", "refseq_name": "twist-related protein 1", "refseq_ac": [ { "id": "NP_445982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445982", "type": "external" } ], "gene_names_uniprotkb": "Twist1", "gene_names_refseq": "Twist1; Twist", "protein_names_uniprotkb": "Twist-related protein 1", "protein_names_refseq": "twist basic helix-loop-helix transcription factor 1; twist gene homolog 1; twist homolog 1; twist-related protein 1", "tax_id": 10116, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); craniosynostosis 1 (Disease Ontology:DOID:0061010); Sweeney-Cox syndrome (Disease Ontology:DOID:0080538); acrocephalosyndactylia (Disease Ontology:DOID:12960); Saethre-Chotzen syndrome (Disease Ontology:DOID:14768); breast cancer (Disease Ontology:DOID:1612); breast carcinoma (Disease Ontology:DOID:3459); pulmonary fibrosis (Disease Ontology:DOID:3770); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:85489); (R-RNO-9764725)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "22673903;32309849;34461141;34616033;39094924", "class_list": "", "function": "Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer., [UniProtKB, UniProtKB]; Exosomes from linc00511-overexpressing ADSCs accelerates angiogenesis in diabetic foot ulcers healing by suppressing PAQR3-induced Twist1 degradation., [RefSeq, PubMed]; MFN2-dependent mitochondrial dysfunction contributes to Relm-beta-induced pulmonary arterial hypertension via USP18/Twist1/miR-214 pathway., [RefSeq, PubMed]; Mechanical stimulation induced osteogenic differentiation of BMSCs through TWIST/E2A/p21 axis., [RefSeq, PubMed]; TWIST1 transcriptionally upregulates complement 3 in glomerular mesangial cells from spontaneously hypertensive rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:2000780 negative regulation of double-strand break repair;GO:0060900 embryonic camera-type eye formation;GO:2000793 cell proliferation involved in heart valve development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9EPJ1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERA7-1", "uniprot_id": [ { "id": "MSLN_RAT", "url": "https://www.uniprot.org/uniprot/Q9ERA7", "type": "external" } ], "mass": 68883.0, "length": 625, "protein_name": "Mesothelin", "gene_name": "Msln", "organism": "Rat", "refseq_name": "mesothelin precursor", "refseq_ac": [ { "id": "NP_113846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113846", "type": "external" } ], "gene_names_uniprotkb": "Msln; Erc; Mpf", "gene_names_refseq": "Msln", "protein_names_uniprotkb": "Mesothelin; Pre-pro-megakaryocyte-potentiating factor; Protein expressed in renal carcinoma", "protein_names_refseq": "ERC/mesothelin; mesothelin precursor; pre-pro-megakaryocyte-potentiating factor; protein expressed in renal carcinoma", "tax_id": 10116, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); pancreas disease (Disease Ontology:DOID:26); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); common bile duct neoplasm (Disease Ontology:DOID:4608); bile duct carcinoma (Disease Ontology:DOID:4897)", "pathway": " (rno:60333); (R-RNO-163125); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10944454;20933535;24944479", "class_list": "", "function": "Megakaryocyte potentiating factor is a useful serum biomarker for the effects of chrysotile exposure on respiratory organs., [RefSeq, PubMed]; Megakaryocyte-potentiating factor (MPF) may potentiate megakaryocyte colony formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Membrane-anchored forms may play a role in cellular adhesion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mesothelin may have an important role in the remodeling of the endocrine pancreas in neonatal rats., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6IRG1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0098552 side of membrane", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:0031016 pancreas development;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9ERA7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERM3-1", "uniprot_id": [ { "id": "DGAT1_RAT", "url": "https://www.uniprot.org/uniprot/Q9ERM3", "type": "external" } ], "mass": 56870.0, "length": 498, "protein_name": "Diacylglycerol O-acyltransferase 1", "gene_name": "Dgat1", "organism": "Rat", "refseq_name": "diacylglycerol O-acyltransferase 1", "refseq_ac": [ { "id": "NP_445889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445889", "type": "external" } ], "gene_names_uniprotkb": "Dgat1; Dgat", "gene_names_refseq": "ARAT; Dgat1; Dgat", "protein_names_uniprotkb": "Diacylglycerol O-acyltransferase 1; 2.3.1.20; 2.3.1.76; ARAT; Acyl-CoA retinol O-fatty-acyltransferase; Diglyceride acyltransferase; Retinol O-fatty-acyltransferase", "protein_names_refseq": "acyl-CoA retinol O-fatty-acyltransferase; acyl-coenzyme A:diacylglycerol acyltransferase 1; diacylglycerol O-acyltransferase 1; diacylglycerol acyltransferase; diglyceride acyltransferase; retinol O-fatty-acyltransferase", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); congenital diarrhea 7 with exudative enteropathy (Disease Ontology:DOID:0060778); nephrotic syndrome (Disease Ontology:DOID:1184); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (rno:84497); (R-RNO-1482883); (R-RNO-6798695); (R-RNO-75109)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "22673903;23449193;27179362;27249207", "class_list": "", "function": "Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats. In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (By similarity). Also present in female mammary glands, where it produces fat in the milk (By similarity). May be involved in VLDL (very low density lipoprotein) assembly (By similarity). In contrast to DGAT2 it is not essential for survival (By similarity). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (By similarity). Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In both wild-type and DGAT-knockdown hepatocytes, oleate co-treatment significantly reduced PA lipid incorporation and overall phospholipid saturation compared to PA-treated hepatocytes, [RefSeq, PubMed]; Pharmacological DGAT-1 inhibition leads to an increase in intestinal FAO and ketogenesis when dietary fat is available., [RefSeq, PubMed]; TAG synthesis and levels of PUFA-TAGs were lowered by the diacylglycerol acyltransferase (DGAT)1 inhibitor, T863. The lipase inhibitor, Atglistatin, increased the levels of TAG in both WT and ATGL-deficient mouse Hepatic stellate cell (HSC). Both Atglistatin and T863 inhibited the induction of activation marker, alpha-smooth muscle actin, in rat HSCs, but not in mouse HSCs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" } ], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0042802 identical protein binding;GO:0004144 diacylglycerol O-acyltransferase activity;GO:0019992 diacylglycerol binding;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:2000491 positive regulation of hepatic stellate cell activation;GO:1903998 regulation of eating behavior;GO:1904729 regulation of intestinal lipid absorption;GO:0001523 retinoid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9ERM3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES73-1", "uniprot_id": [ { "id": "MAGD1_RAT", "url": "https://www.uniprot.org/uniprot/Q9ES73", "type": "external" } ], "mass": 85798.0, "length": 775, "protein_name": "Melanoma-associated antigen D1", "gene_name": "Maged1", "organism": "Rat", "refseq_name": "melanoma-associated antigen D1", "refseq_ac": [ { "id": "NP_445861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445861", "type": "external" } ], "gene_names_uniprotkb": "Maged1; Nrage", "gene_names_refseq": "Maged1; Nrage", "protein_names_uniprotkb": "Melanoma-associated antigen D1; MAGE-D1 antigen; Neurotrophin receptor-interacting MAGE homolog; SNERG-1; Sertoli cell necdin-related gene protein 1", "protein_names_refseq": "MAGE-D1 antigen; SNERG-1; melanoma antigen, family D, 1; melanoma-associated antigen D1; neurotrophin receptor-interacting MAGE homolog; sertoli cell necdin-related gene protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:84469); (R-RNO-9768919)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10985348;11014239;12376548;12598531;20595047;23717400;29393594;34755671;36585447", "class_list": "", "function": "Dynamic expression of Mage-D1 in rat dental germs and potential role in mineralization of ectomesenchymal stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; Effects on neuritogenesis are promoted through interactions of Dlxin-1 with the neurotrophin receptor TrkA, [RefSeq, PubMed]; Identification of NRAGE as a p75NTR interactor capable of inducing caspase activation and cell death through a JNK-dependent mitochondrial apoptotic pathway, [RefSeq, PubMed]; Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed., [UniProtKB, PubMed]; Praja1, through ubiquitination and degradation of NRAGE, inhibits neuronal differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; [Mage-D1 binding to activated p75NTR positively regulates mineralization of rat ectomesenchymal stem cells in vitro]., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q66HP3;Q9JHZ6;Q9QX92", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0004705 JUN kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:1900181 negative regulation of protein localization to nucleus;GO:0045892 negative regulation of DNA-templated transcription;GO:0050680 negative regulation of epithelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9ES73-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESH6-1", "uniprot_id": [ { "id": "GLRX1_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESH6", "type": "external" } ], "mass": 11879.0, "length": 107, "protein_name": "Glutaredoxin-1", "gene_name": "Glrx", "organism": "Rat", "refseq_name": "glutaredoxin-1", "refseq_ac": [ { "id": "NP_071614", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071614", "type": "external" } ], "gene_names_uniprotkb": "Glrx; Glrx1; Grx", "gene_names_refseq": "Glrx1; Glrx; Grx", "protein_names_uniprotkb": "Glutaredoxin-1; TTase-1; Thioltransferase-1", "protein_names_refseq": "TTase-1; glutaredoxin (thioltransferase); glutaredoxin 1 (thioltransferase); glutaredoxin-1; thioltransferase-1", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:64045); (R-RNO-499943)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12217626;19938943;20175144;29393594", "class_list": "", "function": "Grx1 decreases by ~40% in 2-yr-old Fischer 344 rat hearts vs 6-mo-old controls. Grx1 knockdown in H9c2 cardiomyocytes increases apoptosis, & decreases NFkappaB transcription,& production of Bcl-2 & Bcl-xL., [RefSeq, PubMed]; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins., [UniProtKB]; Study reports Cys23 of thioltransferase is an essential residue for catalytic activity & the other Cys26 is also important but Cys79 & Cys83 were not essential; for protection of cells from oxidative stress active thioltransferase is essential, [RefSeq, PubMed]; The presence of enzyme activity in subcellular organelles in brain and liver and in mitochondria demonstrates functional glutaredoxin activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99PB7", "ec_number_list": [], "go_molecular_function": "GO:0015038 glutathione disulfide oxidoreductase activity;GO:0017080 sodium channel regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0060355 positive regulation of cell adhesion molecule production;GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway;GO:0002931 response to ischemia;GO:0032024 positive regulation of insulin secretion;GO:0071333 cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9ESH6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EST9-1", "uniprot_id": [ { "id": "FGF20_RAT", "url": "https://www.uniprot.org/uniprot/Q9EST9", "type": "external" } ], "mass": 23537.0, "length": 212, "protein_name": "Fibroblast growth factor 20", "gene_name": "Fgf20", "organism": "Rat", "refseq_name": "fibroblast growth factor 20", "refseq_ac": [ { "id": "NP_076451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076451", "type": "external" } ], "gene_names_uniprotkb": "Fgf20", "gene_names_refseq": "Fgf20; Fgf4a", "protein_names_uniprotkb": "Fibroblast growth factor 20; FGF-20", "protein_names_refseq": "fibroblast growth factor 20; fibroblast growth factor 4a", "tax_id": 10116, "disease": "renal agenesis (Disease Ontology:DOID:14766)", "pathway": " (rno:66017); (R-RNO-109704); (R-RNO-1257604); (R-RNO-190322); (R-RNO-190371); (R-RNO-190372); (R-RNO-190373); (R-RNO-190375); (R-RNO-5654219); (R-RNO-5654221); (R-RNO-5654227); (R-RNO-5654228); (R-RNO-5654687); (R-RNO-5654688); (R-RNO-5654689); (R-RNO-5654693); (R-RNO-5654695); (R-RNO-5654699); (R-RNO-5654700); (R-RNO-5654704); (R-RNO-5654706); (R-RNO-5654710); (R-RNO-5654712); (R-RNO-5654719); (R-RNO-5654720); (R-RNO-5654726); (R-RNO-5654727); (R-RNO-5654732); (R-RNO-5654733); (R-RNO-5673001); (R-RNO-6811558)", "pathway_count": 31, "publication_count": 3, "publication_id_list": "11032730;15474354;29698669", "class_list": "", "function": "FGF-20 promotes the differentiation of Nurr1-neural stem cells into tyrosine hydroxylase-positive neurons and additional factors are required for the efficient differentiation of dopaminergic neurons in the adult brain., [RefSeq, PubMed]; Neurotrophic factor that regulates central nervous development and function. May play an important role in dopaminergic neurons in the substantia nigra., [UniProtKB]; Results highlighted a protective role for FGF20 in the substantia nigra and identify astrocytes as one potential source of endogenous FGF20. Given FGF20 is localised to astrocytes in the adult substantia nigra, endogenous FGF20 provides its protection of dopamine neurons through a paracrine action. Boosting the endogenous FGF20 production might offer potential as a future therapeutic strategy in Parkinson's disease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0090722 receptor-receptor interaction;GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0043410 positive regulation of MAPK cascade;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9EST9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHY1-1", "uniprot_id": [ { "id": "JAM1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JHY1", "type": "external" } ], "mass": 32370.0, "length": 300, "protein_name": "Junctional adhesion molecule A", "gene_name": "F11r", "organism": "Rat", "refseq_name": "junctional adhesion molecule A precursor", "refseq_ac": [ { "id": "NP_446248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446248", "type": "external" } ], "gene_names_uniprotkb": "F11r; Jam1", "gene_names_refseq": "F11r; Jam1", "protein_names_uniprotkb": "Junctional adhesion molecule A; JAM-1; JAM-A; Junctional adhesion molecule 1", "protein_names_refseq": "JAM-1; JAM-A; junctional adhesion molecule 1; junctional adhesion molecule A precursor; junctional adhesion molecule A", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); peptic esophagitis (Disease Ontology:DOID:13976); breast cancer (Disease Ontology:DOID:1612); transient cerebral ischemia (Disease Ontology:DOID:224); systemic scleroderma (Disease Ontology:DOID:418)", "pathway": " (rno:116479); (R-RNO-202733); (R-RNO-216083); (R-RNO-2173791); (R-RNO-420029)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "22673903;25438062;25916097", "class_list": "", "function": "JAM-A promotes proliferation and inhibits apoptosis of gastric cancer, suggesting that it has a pivotal role in gastric cancer progression., [RefSeq, PubMed]; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration., [UniProtKB, UniProtKB, UniProtKB]; These findings support a key role of JAM-A in promoting tight junction homeostasis and lung barrier function by coordinating interactions among claudins, the tight junction scaffold, and the cytoskeleton., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0042803 protein homodimerization activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0030054 cell junction;GO:0032991 protein-containing complex", "go_biological_process": "GO:0090559 regulation of membrane permeability;GO:0007155 cell adhesion;GO:0030154 cell differentiation;GO:0030855 epithelial cell differentiation;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JHY1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJH3-1", "uniprot_id": [ { "id": "GPR27_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJH3", "type": "external" } ], "mass": 39892.0, "length": 377, "protein_name": "Probable G protein-coupled receptor 27", "gene_name": "Gpr27", "organism": "Rat", "refseq_name": "probable G-protein coupled receptor 27", "refseq_ac": [ { "id": "NP_075587", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075587", "type": "external" } ], "gene_names_uniprotkb": "Gpr27; Sreb1", "gene_names_refseq": "Gpr27; Sreb1", "protein_names_uniprotkb": "Probable G protein-coupled receptor 27; Super conserved receptor expressed in brain 1", "protein_names_refseq": "probable G-protein coupled receptor 27; super conserved receptor expressed in brain 1", "tax_id": 10116, "disease": "", "pathway": " (rno:65275)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10833454;35326460;9479505", "class_list": "", "function": "Orphan receptor. Possible candidate for amine-like G protein coupled receptor (By similarity)., [UniProtKB]; The Activation of GPR27 Increases Cytosolic L-Lactate in 3T3 Embryonic Cells and Astrocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:1900738 positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JJH3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJM7-1", "uniprot_id": [ { "id": "GP1BB_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJM7", "type": "external" } ], "mass": 22175.0, "length": 206, "protein_name": "Platelet glycoprotein Ib beta chain", "gene_name": "Gp1bb", "organism": "Rat", "refseq_name": "platelet glycoprotein Ib beta chain precursor", "refseq_ac": [ { "id": "NP_446382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446382", "type": "external" } ], "gene_names_uniprotkb": "Gp1bb", "gene_names_refseq": "Gp1bb", "protein_names_uniprotkb": "Platelet glycoprotein Ib beta chain; GP-Ib beta; GPIb-beta; GPIbB", "protein_names_refseq": "GP-Ib beta; GPIb-beta; GPIbB; glycoprotein Ib (platelet), beta polypeptide; glycoprotein Ib platelet beta subunit; glycoprotein Ib, beta polypeptide; platelet glycoprotein Ib beta chain precursor; platelet glycoprotein Ib beta chain", "tax_id": 10116, "disease": "Bernard-Soulier syndrome (Disease Ontology:DOID:2217)", "pathway": " (rno:116727); (R-RNO-430116); (R-RNO-9769739); (R-RNO-9769743); (R-RNO-9935598)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "10873671;22673903", "class_list": "", "function": "Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:1990779 glycoprotein Ib-IX-V complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0007597 blood coagulation, intrinsic pathway;GO:0007596 blood coagulation;GO:0051209 release of sequestered calcium ion into cytosol;GO:0035855 megakaryocyte development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JJM7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKA8-1", "uniprot_id": [ { "id": "HCN3_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKA8", "type": "external" } ], "mass": 86809.0, "length": 780, "protein_name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3", "gene_name": "Hcn3", "organism": "Rat", "refseq_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3", "refseq_ac": [ { "id": "NP_446137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446137", "type": "external" } ], "gene_names_uniprotkb": "Hcn3", "gene_names_refseq": "Hcn3", "protein_names_uniprotkb": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3", "protein_names_refseq": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:114245); (R-RNO-1296061)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11000485;12786975;14991560;22673903;26341471;27496876;27569278;32962418;38843836", "class_list": "", "function": "Data suggest that HCN channels might play an important role in affecting contraction frequency of lymphatic muscle cells., [RefSeq, PubMed]; Densely clustered at synaptic terminals of retinal bipolar cells and photoreceptors., [RefSeq, PubMed]; During the senescent process, the HCN2 and HCN4 protein levels declined., [RefSeq, PubMed]; Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions, with an about 3:1 preference for potassium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). In particular, plays a pivotal role in maintaining excitability and promoting rhythmic burst firing within hypothalamic nuclei. Exerts a significant influence on the configuration of the cardiac action potential waveform. Does not appear to play a prominent role in the processing of acute, neuropathic, or inflammatory pain., [UniProtKB, UniProtKB]; Immunoreactivity for HCN3 in rat brain shows subcortical distribution mainly concentrated in the hypothalamus., [RefSeq, PubMed]; Involvement of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 3 in Oxytocin Neuronal Activity in Lactating Rats With Pup Deprivation., [RefSeq, PubMed]; The expression and relative abundances of HCN channels in cerebellum and primary cultures of cerebellar granule neurons, is described., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005248 voltage-gated sodium channel activity;GO:0005249 voltage-gated potassium channel activity;GO:0030552 cAMP binding;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0071320 cellular response to cAMP;GO:1903351 cellular response to dopamine;GO:0035725 sodium ion transmembrane transport;GO:0003254 regulation of membrane depolarization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JKA8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKB0-1", "uniprot_id": [ { "id": "HCN1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKB0", "type": "external" } ], "mass": 101429.0, "length": 902, "protein_name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1", "gene_name": "Hcn1", "organism": "Rat", "refseq_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1", "refseq_ac": [ { "id": "NP_445827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445827", "type": "external" } ], "gene_names_uniprotkb": "Hcn1", "gene_names_refseq": "Hcn1", "protein_names_uniprotkb": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1", "protein_names_refseq": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 24 (Disease Ontology:DOID:0080429); complex cortical dysplasia with other brain malformations (Disease Ontology:DOID:0090131); generalized epilepsy with febrile seizures plus 10 (Disease Ontology:DOID:0111296); sick sinus syndrome (Disease Ontology:DOID:13884); status epilepticus (Disease Ontology:DOID:1824); childhood absence epilepsy (Disease Ontology:DOID:1825); anxiety disorder (Disease Ontology:DOID:2030); mood disorder (Disease Ontology:DOID:3324); temporal lobe epilepsy (Disease Ontology:DOID:3328); meningitis (Disease Ontology:DOID:9471)", "pathway": " (rno:84390); (R-RNO-1296061)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11000485;11675786;12389030;32248813;34845181;34875252;36336089;38555654;38843836", "class_list": "", "function": "Activation of HCN channels caused by elevated cAMP levels in periaqueductal gray promotes bone cancer pain., [RefSeq, PubMed]; Alterations in HCN1 expression and distribution during epileptogenesis in rats., [RefSeq, PubMed]; Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions. Exhibits weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (By similarity). Participates in cerebellar mechanisms of motor learning (By similarity). May mediate responses to sour stimuli (PubMed:11675786)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; In apical dendrites of hippocampal, subicular and neocortical layer-5 pyramidal cells, [RefSeq, PubMed]; Moxibustion Regulates Gastrointestinal Motility via HCN1 in Functional Dyspepsia Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Role of hyperpolarization-activated cyclic nucleotide-gated channels in aging bladder phenotype., [RefSeq, PubMed]; The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F1LSH6", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0042802 identical protein binding;GO:0005248 voltage-gated sodium channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0019228 neuronal action potential;GO:0042391 regulation of membrane potential;GO:0051289 protein homotetramerization;GO:0051592 response to calcium ion;GO:0071320 cellular response to cAMP", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JKB0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QX79-1", "uniprot_id": [ { "id": "FETUB_RAT", "url": "https://www.uniprot.org/uniprot/Q9QX79", "type": "external" } ], "mass": 41563.0, "length": 378, "protein_name": "Fetuin-B", "gene_name": "Fetub", "organism": "Rat", "refseq_name": "fetuin-B precursor", "refseq_ac": [ { "id": "NP_445800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445800", "type": "external" } ], "gene_names_uniprotkb": "Fetub", "gene_names_refseq": "Fetub; Fet; IRL685; Pp63", "protein_names_uniprotkb": "Fetuin-B; Fetuin-like protein IRL685", "protein_names_refseq": "fetuin beta; fetuin phosphoprotein; fetuin-B precursor; fetuin-like protein IRL685", "tax_id": 10116, "disease": "", "pathway": " (rno:83928)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10947975;12676929;21454685;37364770", "class_list": "", "function": "Fetuin inhibits calcium phosphate precipitation and forms a fetuin-mineral complex, [RefSeq, PubMed]; Pancreastatin deteriorates hepatic lipid metabolism via elevating fetuin B in ovariectomized rats., [RefSeq, PubMed]; Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "F1LN83", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0007338 single fertilization;GO:0010951 negative regulation of endopeptidase activity;GO:0060255 regulation of macromolecule metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QX79-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXI3-1", "uniprot_id": [ { "id": "GPR26_RAT", "url": "https://www.uniprot.org/uniprot/Q9QXI3", "type": "external" } ], "mass": 37805.0, "length": 337, "protein_name": "G protein-coupled receptor 26", "gene_name": "Gpr26", "organism": "Rat", "refseq_name": "G-protein coupled receptor 26", "refseq_ac": [ { "id": "NP_620196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620196", "type": "external" } ], "gene_names_uniprotkb": "Gpr26", "gene_names_refseq": "Gpr26", "protein_names_uniprotkb": "G protein-coupled receptor 26", "protein_names_refseq": "G-protein coupled receptor 26; probable G-protein coupled receptor 26", "tax_id": 10116, "disease": "", "pathway": " (rno:192153)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10684976;28270014", "class_list": "", "function": "Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP (By similarity)., [UniProtKB]; We conclude that the orphan receptors GPR26, GPR39v1, and GPR39v2 are expressed in different tissues and their profile expression is dependent on the etiology of the Metabolic syndrome ., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QXI3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QY16-1", "uniprot_id": [ { "id": "DDX25_RAT", "url": "https://www.uniprot.org/uniprot/Q9QY16", "type": "external" } ], "mass": 54791.0, "length": 483, "protein_name": "ATP-dependent RNA helicase DDX25", "gene_name": "Ddx25", "organism": "Rat", "refseq_name": "ATP-dependent RNA helicase DDX25", "refseq_ac": [ { "id": "NP_113818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113818", "type": "external" } ], "gene_names_uniprotkb": "Ddx25; Grth", "gene_names_refseq": "Ddx25; GRTH", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX25; 3.6.4.13; DEAD box protein 25; Gonadotropin-regulated testicular RNA helicase", "protein_names_refseq": "ATP-dependent RNA helicase DDX25; DEAD (Asp-Glu-Ala-Asp) box helicase 25; DEAD (Asp-Glu-Ala-Asp) box polypeptide 25; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 25; DEAD box protein 25; gonadotropin-regulated testicular RNA helicase", "tax_id": 10116, "disease": "", "pathway": " (rno:58856)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10608860;12734186;16968703;21691948;22038044;22673903", "class_list": "", "function": "ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity)., [UniProtKB]; Expression is regulated by gonadotropin/androgen at the translational level, [RefSeq, PubMed]; Studies on GRTH [proide insights into the intrinsic requirements of spermatogenesis and open new avenues for studies on regulating spermatogenesis, infertility and male contraception, [RefSeq, PubMed]; The results of this study indicate that the mammalian GRTH/Ddx25 gene is a multifunctional RNA helicase that is an essential regulator of sperm maturation., [RefSeq, PubMed]; The results suggest that DDX25 functions in meiotic cells,intermitochondrial cement,loose aggregates of particles,chromatoid bodies,late chromatoid bodies,satellite bodies,granulated bodies,mitochondria-associated granules and reticulated bodies., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule;GO:0033391 chromatoid body", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006406 mRNA export from nucleus;GO:0006417 regulation of translation;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QY16-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYH7-1", "uniprot_id": [ { "id": "GHRL_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYH7", "type": "external" } ], "mass": 13176.0, "length": 117, "protein_name": "Appetite-regulating hormone", "gene_name": "Ghrl", "organism": "Rat", "refseq_name": "appetite-regulating hormone preproprotein", "refseq_ac": [ { "id": "NP_067701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067701", "type": "external" } ], "gene_names_uniprotkb": "Ghrl", "gene_names_refseq": "Ghrl", "protein_names_uniprotkb": "Appetite-regulating hormone; Growth hormone secretagogue; Growth hormone-releasing peptide; Motilin-related peptide", "protein_names_refseq": "appetite-regulating hormone preproprotein; appetite-regulating hormone; ghrelin/obestatin prepropeptide; growth hormone secretagogue; growth hormone-releasing peptide; motilin-related peptide", "tax_id": 10116, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); morbid obesity (Disease Ontology:DOID:11981); Prader-Willi syndrome (Disease Ontology:DOID:11983); cardiovascular system disease (Disease Ontology:DOID:1287); multiple endocrine neoplasia (Disease Ontology:DOID:3125); middle cerebral artery infarction (Disease Ontology:DOID:3525); esophagus adenocarcinoma (Disease Ontology:DOID:4914); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:59301); (R-RNO-416476); (R-RNO-422085)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10604470;10801861;11162448;11306336;11549267;16284174;17289961;37722460;38158667;38177343;38187112;39187389", "class_list": "", "function": "Does ghrelin regulate intestinal motility in rabbits? An in vitro study using isolated duodenal strips., [RefSeq, PubMed]; Ghrelin Modulates Voltage-Gated Ca[2+] Channels through Voltage-Dependent and Voltage-Independent Pathways in Rat Gastric Vagal Afferent Neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (By similarity). Octanoylated ghrelin-28 is the most commonly found ghrelin and octanoylation is essential for the activation of the growth hormone secretagogue receptor type 1 (GHSR) (By similarity). Induces the release of growth hormone from the pituitary (By similarity). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation., [UniProtKB, UniProtKB]; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation., [UniProtKB, UniProtKB]; Ghrelin mediated cardioprotection using in vitro models of oxidative stress., [RefSeq, PubMed]; Ghrelin suppresses hypoxia/reoxygenation-induced H9C2 cell pyroptosis via NLRP3. Publication Status: Online-Only, [RefSeq, PubMed]; Ghrelin/GHSR Axis Induced M2 Macrophage and Alleviated Intestinal Barrier Dysfunction in a Sepsis Rat Model by Inactivating E2F1/NF-kappaB Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility., [UniProtKB, UniProtKB, UniProtKB]; Precursor of the appetite-regulating peptide ghrelin, including ghrelin-27 and ghrelin-28., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ET69", "ec_number_list": [], "go_molecular_function": "GO:0031768 ghrelin receptor binding;GO:0001664 G protein-coupled receptor binding;GO:0005179 hormone activity;GO:0030296 protein tyrosine kinase activator activity;GO:0016608 growth hormone-releasing hormone activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030424 axon", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0032095 regulation of response to food;GO:0032100 positive regulation of appetite;GO:0120058 positive regulation of small intestinal transit;GO:1903012 positive regulation of bone development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9QYH7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZP1-1", "uniprot_id": [ { "id": "GEMI2_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZP1", "type": "external" } ], "mass": 30441.0, "length": 269, "protein_name": "Gem-associated protein 2", "gene_name": "Gemin2", "organism": "Rat", "refseq_name": "gem-associated protein 2", "refseq_ac": [ { "id": "NP_445841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445841", "type": "external" } ], "gene_names_uniprotkb": "Gemin2; Sip1", "gene_names_refseq": "Gemin2; Sip1", "protein_names_uniprotkb": "Gem-associated protein 2; Component of gems 2; Gemin-2; SMN-interacting protein 1; Survival of motor neuron protein-interacting protein 1", "protein_names_refseq": "SMN-interacting protein 1; component of gems 2; gem-associated protein 2; gemin-2; survival of motor neuron protein-interacting protein 1", "tax_id": 10116, "disease": "spinal muscular atrophy (Disease Ontology:DOID:12377)", "pathway": " (rno:84404); (R-RNO-191859)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23319195", "class_list": "", "function": "In rat spinal cord neurons, the immunoexpression of SMN and gemins 2 and 4 is present through the whole animal lifespan, are present in the same motoneurons and immunoexpression of gemin 2 and 4 decreases slightly with aging., [RefSeq, PubMed]; The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (By similarity). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (By similarity). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity). Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4G084", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0016604 nuclear body", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000245 spliceosomal complex assembly;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QZP1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0A8-1", "uniprot_id": [ { "id": "HAUS1_RAT", "url": "https://www.uniprot.org/uniprot/Q9R0A8", "type": "external" } ], "mass": 31497.0, "length": 278, "protein_name": "HAUS augmin-like complex subunit 1", "gene_name": "Haus1", "organism": "Rat", "refseq_name": "HAUS augmin-like complex subunit 1", "refseq_ac": [ { "id": "NP_620219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620219", "type": "external" } ], "gene_names_uniprotkb": "Haus1; Ccdc5", "gene_names_refseq": "Ccdc5; Haus1", "protein_names_uniprotkb": "HAUS augmin-like complex subunit 1; Coiled-coil domain-containing protein 5", "protein_names_refseq": "HAUS augmin-like complex subunit 1-like; HAUS augmin-like complex subunit 1; coiled-coil domain containing 5; coiled-coil domain-containing protein 5", "tax_id": 10116, "disease": "", "pathway": " (rno:192228); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-8854518)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L123", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005829 cytosol;GO:0070652 HAUS complex;GO:1990498 mitotic spindle microtubule", "go_biological_process": "GO:0051301 cell division;GO:0007098 centrosome cycle;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9R0A8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0C5-1", "uniprot_id": [ { "id": "GALT7_RAT", "url": "https://www.uniprot.org/uniprot/Q9R0C5", "type": "external" } ], "mass": 75335.0, "length": 657, "protein_name": "N-acetylgalactosaminyltransferase 7", "gene_name": "Galnt7", "organism": "Rat", "refseq_name": "N-acetylgalactosaminyltransferase 7", "refseq_ac": [ { "id": "NP_075215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075215", "type": "external" } ], "gene_names_uniprotkb": "Galnt7", "gene_names_refseq": "Galnt7", "protein_names_uniprotkb": "N-acetylgalactosaminyltransferase 7; 2.4.1.41; GalNAc-T7; Polypeptide GalNAc transferase 7; Protein-UDP acetylgalactosaminyltransferase 7; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7; pp-GaNTase 7", "protein_names_refseq": "N-acetylgalactosaminyltransferase 7; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7); galNAc-T7; polypeptide GalNAc transferase 7; pp-GaNTase 7; protein-UDP acetylgalactosaminyltransferase 7", "tax_id": 10116, "disease": "", "pathway": " (rno:29750); (R-RNO-913709)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10488133", "class_list": "glycogene;glycosyltransferase", "function": "Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 7434, "hit_score": 0.2, "record_id": "Q9R0C5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R237-1", "uniprot_id": [ { "id": "JIP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9R237", "type": "external" } ], "mass": 77318.0, "length": 708, "protein_name": "C-Jun-amino-terminal kinase-interacting protein 1", "gene_name": "Mapk8ip1", "organism": "Rat", "refseq_name": "C-Jun-amino-terminal kinase-interacting protein 1 isoform 3", "refseq_ac": [ { "id": "NP_446229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446229", "type": "external" } ], "gene_names_uniprotkb": "Mapk8ip1; Ib1; Jip1; Mapk8ip", "gene_names_refseq": "JIP1; Jip-1; Mapk8ip1; Mapk8ip", "protein_names_uniprotkb": "C-Jun-amino-terminal kinase-interacting protein 1; IB-1; Islet-brain-1; JIP-1-related protein; JIP-1; JNK MAP kinase scaffold protein 1; JNK-interacting protein 1; JRP; Mitogen-activated protein kinase 8-interacting protein 1", "protein_names_refseq": "C-Jun-amino-terminal kinase-interacting protein 1 isoform 3; C-jun-amino-terminal kinase-interacting protein 1; IB-1; JIP-1-related protein; JNK MAP kinase scaffold protein 1; JNK-interacting protein 1; JRP; islet-brain-1; mitogen activated protein kinase 8 interacting protein", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:116457)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10098834;16456539;21076496;22128169;22673903;24478353;26665154;28886967;36902422;9442013", "class_list": "", "function": "Dual Role of Mitogen-Activated Protein Kinase 8 Interacting Protein-1 in Inflammasome and Pancreatic beta-Cell Function. Publication Status: Online-Only, [RefSeq, PubMed]; HDAC-dependent regulatory circuit that promotes formation of JIP1:KIF5A:microtubule complexes that regulate intracellular transport of cargo such as autophagosomes, is reported., [RefSeq, PubMed]; Suppression of IB1 level mimicked the harmful effects of palmitate on the beta cell survival and GSIS. Conversely, ectopic expression of IB1 counteracted the deleterious effects of palmitate on the beta cell survival and insulin secretion, [RefSeq, PubMed]; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells., [UniProtKB, UniProtKB, PubMed]; This study demonistrated that JIP1 mediates anterograde transport of Rab10 cargos during neuronal polarization, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 29, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B0VXR5;O88979;Q9R1H8;Q9WVI5;Q9WVI6", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0031434 mitogen-activated protein kinase kinase binding;GO:0019894 kinesin binding;GO:0005078 MAP-kinase scaffold activity", "go_cellular_component": "GO:0044302 dentate gyrus mossy fiber;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007258 JUN phosphorylation;GO:2000564 regulation of CD8-positive, alpha-beta T cell proliferation;GO:0007165 signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9R237-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVK7-1", "uniprot_id": [ { "id": "HCDH_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVK7", "type": "external" } ], "mass": 34448.0, "length": 314, "protein_name": "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial", "gene_name": "Hadh", "organism": "Rat", "refseq_name": "hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_476534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476534", "type": "external" } ], "gene_names_uniprotkb": "Hadh; Hadhsc; Had; Schad", "gene_names_refseq": "Hadhsc; Hadh", "protein_names_uniprotkb": "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; 1.1.1.35; HCDH; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase", "protein_names_refseq": "HCDH; L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain; NAD-dependent dehydrogenase; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; hydroxylacyl-Coenzyme A dehydrogenase, short chain; medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; monofunctional; short-chain 3-hydroxyacyl-CoA dehydrogenase", "tax_id": 10116, "disease": "familial hyperinsulinemic hypoglycemia 4 (Disease Ontology:DOID:0070215); myocardial infarction (Disease Ontology:DOID:5844); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:113965); (R-RNO-77310); (R-RNO-77346); (R-RNO-77348); (R-RNO-77350); (R-RNO-77352); (R-RNO-9837999)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "10064895;17491019;26446791;27213235;34502162", "class_list": "", "function": "Analysis of beta cell expression of L-3-hydroxyacyl-CoA dehydrogenase, short chain, and its role in down-regulating insulin release, [RefSeq, PubMed]; Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (By similarity). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "1.1.1.211", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.211", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0070403 NAD+ binding;GO:0003857 (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0046676 negative regulation of insulin secretion;GO:0050796 regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9WVK7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVR8-1", "uniprot_id": [ { "id": "MEN1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVR8", "type": "external" } ], "mass": 67335.0, "length": 610, "protein_name": "Menin", "gene_name": "Men1", "organism": "Rat", "refseq_name": "menin", "refseq_ac": [ { "id": "NP_062081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062081", "type": "external" } ], "gene_names_uniprotkb": "Men1", "gene_names_refseq": "Men1; menin", "protein_names_uniprotkb": "Menin", "protein_names_refseq": "menin; multiple endocrine neoplasia 1; multiple endocrine neoplasia I; multiple endocrine neoplasia type I", "tax_id": 10116, "disease": "multiple endocrine neoplasia type 1 (Disease Ontology:DOID:10017); hyperparathyroidism (Disease Ontology:DOID:13543); cancer (Disease Ontology:DOID:162); congenital heart disease (Disease Ontology:DOID:1682); pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); prolactinoma (Disease Ontology:DOID:5394); gastrinoma (Disease Ontology:DOID:5577); growth hormone secreting pituitary adenoma (Disease Ontology:DOID:6255); duodenal gastrinoma (Disease Ontology:DOID:7959)", "pathway": " (rno:29417); (R-RNO-201722); (R-RNO-2173796); (R-RNO-3769402); (R-RNO-381426); (R-RNO-5626467); (R-RNO-8957275); (R-RNO-9772755)", "pathway_count": 8, "publication_count": 7, "publication_id_list": "10524203;10612420;11274402;22673903;24531709;30792230;31652443", "class_list": "", "function": "CDK4 is a critical downstream target of MEN1-dependent tumor suppression and is required for tumorigenic proliferation in the pituitary and pancreatic islet, whereas CDK2 is dispensable for tumorigenesis in these neuroendocrine cell types., [RefSeq, PubMed]; Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair (By similarity). Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Results have uncovered a previously unappreciated physiological link in which GLP-1 signaling suppresses menin function through phosphorylation-triggered and actin/myosin cytoskeletal protein-mediated derepression of gene transcription., [RefSeq, PubMed]; Wild-type menin is rapidly degraded via the ubiquitin-proteasome pathway in a rat insulinoma cell line., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3ZCA2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051219 phosphoprotein binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0002051 osteoblast fate commitment;GO:0046621 negative regulation of organ growth;GO:0071559 response to transforming growth factor beta;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WVR8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z288-1", "uniprot_id": [ { "id": "GCM1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z288", "type": "external" } ], "mass": 49522.0, "length": 436, "protein_name": "Chorion-specific transcription factor GCMa", "gene_name": "Gcm1", "organism": "Rat", "refseq_name": "chorion-specific transcription factor GCMa", "refseq_ac": [ { "id": "NP_058882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058882", "type": "external" } ], "gene_names_uniprotkb": "Gcm1", "gene_names_refseq": "Gcm1; Gcma", "protein_names_uniprotkb": "Chorion-specific transcription factor GCMa; GCM motif protein 1; Glial cells missing homolog 1", "protein_names_refseq": "GCM motif protein 1; chorion-specific transcription factor GCMa; glial cells missing homolog 1", "tax_id": 10116, "disease": "", "pathway": " (rno:29394)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9770492", "class_list": "", "function": "Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060706 cell differentiation involved in embryonic placenta development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z288-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2K0-1", "uniprot_id": [ { "id": "DEDD_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2K0", "type": "external" } ], "mass": 36847.0, "length": 318, "protein_name": "Death effector domain-containing protein", "gene_name": "Dedd", "organism": "Rat", "refseq_name": "death effector domain-containing protein", "refseq_ac": [ { "id": "NP_113988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113988", "type": "external" } ], "gene_names_uniprotkb": "Dedd; Deft", "gene_names_refseq": "Dedd; Deft", "protein_names_uniprotkb": "Death effector domain-containing protein; Death effector domain-containing testicular molecule", "protein_names_refseq": "death effector domain-containing protein; death effector domain-containing testicular molecule", "tax_id": 10116, "disease": "", "pathway": " (rno:83631)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9832420", "class_list": "", "function": "A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0042981 regulation of apoptotic process;GO:0042177 negative regulation of protein catabolic process;GO:0046697 decidualization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z2K0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2K5-1", "uniprot_id": [ { "id": "LST8_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2K5", "type": "external" } ], "mass": 35943.0, "length": 326, "protein_name": "Target of rapamycin complex subunit LST8", "gene_name": "Mlst8", "organism": "Rat", "refseq_name": "target of rapamycin complex subunit LST8", "refseq_ac": [ { "id": "NP_071799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071799", "type": "external" } ], "gene_names_uniprotkb": "Mlst8; Gbl; Lst8", "gene_names_refseq": "Gbl; Mlst8", "protein_names_uniprotkb": "Target of rapamycin complex subunit LST8; G protein beta subunit-like; Mammalian lethal with SEC13 protein 8; Protein GbetaL; TORC subunit LST8; mLST8", "protein_names_refseq": "G beta-like protein; MTOR associated protein, LST8 homolog; TORC subunit LST8; mammalian lethal with SEC13 protein 8; protein GbetaL; target of rapamycin complex subunit LST8", "tax_id": 10116, "disease": "", "pathway": " (rno:64226); (R-RNO-1257604); (R-RNO-1632852); (R-RNO-165159); (R-RNO-166208); (R-RNO-3371571); (R-RNO-380972); (R-RNO-389357); (R-RNO-5218920); (R-RNO-5628897); (R-RNO-6804757); (R-RNO-8943724); (R-RNO-9639288); (R-RNO-9856530)", "pathway_count": 14, "publication_count": 2, "publication_id_list": "11182770;21779001", "class_list": "", "function": "Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. In response to nutrients, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy. The mTORC1 complex is inhibited in response to starvation and amino acid depletion. Within mTORC1, MLST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. As part of the mTORC2 complex, transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1. mTORC2 functions upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. 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Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. May act as a regulator of multipotency in embryonic stem cells. 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(R-RNO-3214815); (R-RNO-73762); (R-RNO-8943724); (R-RNO-9937850); (R-RNO-9940951)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, 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"filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JTQ0-1", "uniprot_id": [ { "id": "A0A0G2JTQ0_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JTQ0", "type": "external" } ], "mass": 8358.0, "length": 69, "protein_name": "Uncharacterized protein", "gene_name": "Smim31", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Smim31", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, 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"record_id": "A0A0G2JTQ0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JTQ2-1", "uniprot_id": [ { "id": "A0A0G2JTQ2_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JTQ2", "type": "external" } ], "mass": 15973.0, "length": 132, "protein_name": "Binder of sperm protein homolog 1", "gene_name": "Bsph1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Bsph1", "gene_names_refseq": "", "protein_names_uniprotkb": "Binder of sperm protein homolog 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, 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"reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0003823 antigen binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042571 immunoglobulin complex, circulating", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0042113 B cell activation;GO:0006958 complement activation, classical pathway;GO:1903131 mononuclear cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JTV0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JTX2-1", "uniprot_id": [ { "id": "A0A0G2JTX2_RAT", "url": 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"Alpha-mannosidase", "gene_name": "Man2a2", "organism": "Rat", "refseq_name": "alpha-mannosidase 2x isoform 1", "refseq_ac": [ { "id": "NP_001425115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001425115", "type": "external" } ], "gene_names_uniprotkb": "Man2a2", "gene_names_refseq": "Man2a2", "protein_names_uniprotkb": "Alpha-mannosidase; 3.2.1.-", "protein_names_refseq": "alpha-mannosidase 2x isoform 1; alpha-mannosidase 2x; mannosidase 2, alpha 2", "tax_id": 10116, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:308757); (R-RNO-975578)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.114", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004559 alpha-mannosidase activity;GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds;GO:0015923 mannosidase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006491 N-glycan processing;GO:0006013 mannose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JWG1-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JY53-1", "uniprot_id": [ { "id": "A0A0G2JY53_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JY53", "type": "external" } ], "mass": 221716.0, "length": 1928, "protein_name": "Myosin, heavy chain 15", "gene_name": "Myh15", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Myh15", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin, heavy chain 15", "protein_names_refseq": "", "tax_id": 10116, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); stroke (Disease Ontology:DOID:0051061); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); distal myopathy (Disease Ontology:DOID:11720); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032982 myosin filament;GO:0016460 myosin II complex", "go_biological_process": "GO:0002074 extraocular skeletal muscle development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JY53-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JYF9-1", "uniprot_id": [ { "id": "A0A0G2JYF9_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JYF9", "type": "external" } ], "mass": 52246.0, "length": 481, "protein_name": "Matrilin-3", "gene_name": "Matn3", "organism": "Rat", "refseq_name": "matrilin-3 precursor", "refseq_ac": [ { "id": "NP_001382499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382499", "type": "external" } ], "gene_names_uniprotkb": "Matn3", "gene_names_refseq": "Matn3", "protein_names_uniprotkb": "Matrilin-3", "protein_names_refseq": "matrilin-3 precursor", "tax_id": 10116, "disease": "multiple epiphyseal dysplasia 5 (Disease Ontology:DOID:0070299); Marfan syndrome (Disease Ontology:DOID:14323); osteochondrodysplasia (Disease Ontology:DOID:2256); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "38230623", "class_list": "", "function": "Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks., [UniProtKB, UniProtKB]; YTHDF2-regulated matrilin-3 mitigates post-reperfusion hemorrhagic transformation in ischemic stroke via the PI3K/AKT pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0120216 matrilin complex", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JYF9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JZ70-1", "uniprot_id": [ { "id": "A0A0G2JZ70_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JZ70", "type": "external" } ], "mass": 23460.0, "length": 213, "protein_name": "Transcription initiation factor TFIID subunit 12", "gene_name": "Taf12", "organism": "Rat", "refseq_name": "transcription initiation factor TFIID subunit 12 isoform 1", "refseq_ac": [ { "id": "NP_001426268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001426268", "type": "external" } ], "gene_names_uniprotkb": "Taf12", "gene_names_refseq": "Taf12", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 12", "protein_names_refseq": "TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor; transcription initiation factor TFIID subunit 12 isoform 1; transcription initiation factor TFIID subunit 12", "tax_id": 10116, "disease": "", "pathway": " (rno:682902); (R-RNO-674695); (R-RNO-6804756); (R-RNO-73776); (R-RNO-73779); (R-RNO-75953); (R-RNO-76042)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0046982 protein heterodimerization activity;GO:0016251 RNA polymerase II general transcription initiation factor activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0033276 transcription factor TFTC complex;GO:0005634 nucleus;GO:0005669 transcription factor TFIID complex;GO:0000124 SAGA complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0042789 mRNA transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JZ70-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JZA6-1", "uniprot_id": [ { "id": "A0A0G2JZA6_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JZA6", "type": "external" } ], "mass": 14006.0, "length": 118, "protein_name": "Ribosomal protein L22 like 3", "gene_name": "Rpl22l3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rpl22l3; AABR07043141.1; LOC688712", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribosomal protein L22 like 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:688712)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JZA6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JZS4-1", "uniprot_id": [ { "id": "A0A0G2JZS4_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JZS4", "type": "external" } ], "mass": 40782.0, "length": 355, "protein_name": "UDP-D-glucose 4,6-dehydratase", "gene_name": "Tgds", "organism": "Rat", "refseq_name": "dTDP-D-glucose 4,6-dehydratase", "refseq_ac": [ { "id": "NP_001381658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001381658", "type": "external" } ], "gene_names_uniprotkb": "Tgds", "gene_names_refseq": "Tgds", "protein_names_uniprotkb": "UDP-D-glucose 4,6-dehydratase; 4.2.1.76; dTDP-D-glucose 4,6-dehydratase", "protein_names_refseq": "dTDP-D-glucose 4,6-dehydratase", "tax_id": 10116, "disease": "Catel Manzke syndrome (Disease Ontology:DOID:0081122)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "UTP-glucose 4,6-dehydratase that converts UDP-glucose into UDP-4-keto-6-deoxyglucose, and which is required for glycosaminoglycan biosynthesis and skeletal development. UDP-4-keto-6-deoxyglucose is a mimic of the reaction intermediate of UXS1 and acts as an enzyme-rescue metabolite to promote the completion of UXS1 catalytic cycle when NAD(+) levels are low. Under low NAD(+) conditions, UXS1 forms an inactive UDP-4-ketoxylose intermediate bound to NADH, impairing the synthesis of specific glycans that are essential for skeletal development. UDP-4-keto-6-deoxyglucose is used by the inactive NADH-bound UXS1 to produce UDP-6-deoxyglucose and NAD(+) within the catalytic pocket of UXS1, regenerating the essential cofactor NAD(+)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.76", "type": "external" } ], "go_molecular_function": "GO:0008460 dTDP-glucose 4,6-dehydratase activity;GO:0050377 UDP-glucose 4,6-dehydratase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006024 glycosaminoglycan biosynthetic process;GO:0009225 nucleotide-sugar metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JZS4-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JZS9-1", "uniprot_id": [ { "id": "A0A0G2JZS9_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JZS9", "type": "external" } ], "mass": 10738.0, "length": 98, "protein_name": "Ig-like domain-containing protein", "gene_name": "AABR07034736.1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AABR07034736.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig-like domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-173623); (R-RNO-198933); (R-RNO-202733); (R-RNO-2029481); (R-RNO-2029482); (R-RNO-2029485); (R-RNO-2168880); (R-RNO-2454202); (R-RNO-2730905); (R-RNO-2871796); (R-RNO-2871809); (R-RNO-2871837); (R-RNO-5690714); (R-RNO-977606); (R-RNO-983695)", "pathway_count": 15, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JZS9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K002-1", "uniprot_id": [ { "id": "A0A0G2K002_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K002", "type": "external" } ], "mass": 43736.0, "length": 373, "protein_name": "LINE-1 retrotransposable element ORF1 protein", "gene_name": "ENSRNOG00000069224", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000069224", "gene_names_refseq": "", "protein_names_uniprotkb": "LINE-1 retrotransposable element ORF1 protein; LINE retrotransposable element 1; LINE1 retrotransposable element 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000166 nucleotide binding;GO:0003727 single-stranded RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0032197 retrotransposition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K002-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K046-1", "uniprot_id": [ { "id": "A0A0G2K046_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K046", "type": "external" } ], "mass": 143752.0, "length": 1306, "protein_name": "Myopalladin", "gene_name": "Mypn", "organism": "Rat", "refseq_name": "myopalladin", "refseq_ac": [ { "id": "NP_001355746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001355746", "type": "external" } ], "gene_names_uniprotkb": "Mypn", "gene_names_refseq": "Mypn", "protein_names_uniprotkb": "Myopalladin", "protein_names_refseq": "myopalladin", "tax_id": 10116, "disease": "dilated cardiomyopathy 1KK (Disease Ontology:DOID:0110445); nemaline myopathy 11 (Disease Ontology:DOID:0110933); restrictive cardiomyopathy (Disease Ontology:DOID:397)", "pathway": " (rno:309760)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;34502162", "class_list": "", "function": "Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0031674 I band;GO:0030018 Z disc;GO:0005634 nucleus", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A0G2K046-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K0C1-1", "uniprot_id": [ { "id": "A0A0G2K0C1_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K0C1", "type": "external" } ], "mass": 62909.0, "length": 560, "protein_name": "Carboxylic ester hydrolase", "gene_name": "Ces2g", "organism": "Rat", "refseq_name": "carboxylesterase 2G precursor", "refseq_ac": [ { "id": "NP_001099645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099645", "type": "external" } ], "gene_names_uniprotkb": "Ces2g", "gene_names_refseq": "Ces2g; Ces2l; RGD1308358", "protein_names_uniprotkb": "Carboxylic ester hydrolase; 3.1.1.-", "protein_names_refseq": "carboxylesterase 2G precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:291952)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0052689 carboxylic ester hydrolase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K0C1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K0E7-1", "uniprot_id": [ { "id": "A0A0G2K0E7_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K0E7", "type": "external" } ], "mass": 122617.0, "length": 1070, "protein_name": "Ubiquitin-protein ligase E3B", "gene_name": "Ube3b", "organism": "Rat", "refseq_name": "ubiquitin-protein ligase E3B", "refseq_ac": [ { "id": "NP_001137366", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137366", "type": "external" } ], "gene_names_uniprotkb": "Ube3b", "gene_names_refseq": "Ube3b", "protein_names_uniprotkb": "Ubiquitin-protein ligase E3B; 2.3.2.26; HECT-type ubiquitin transferase E3B", "protein_names_refseq": "ubiquitin protein ligase E3; ubiquitin-protein ligase E3B", "tax_id": 10116, "disease": "Kaufman oculocerebrofacial syndrome (Disease Ontology:DOID:0111456)", "pathway": " (rno:687633); (R-RNO-983168)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates BCKDK and targets it for degradation, thereby regulating various metabolic processes. Involved in the positive regulation of neurite branching in hippocampal neurons and the control of neuronal spine number and morphology, through the ubiquitination of PPP3CC., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005739 mitochondrion;GO:0014069 postsynaptic density;GO:0098794 postsynapse", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2K0E7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K0H3-1", "uniprot_id": [ { "id": "A0A0G2K0H3_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K0H3", "type": "external" } ], "mass": 180094.0, "length": 1611, "protein_name": "Low-density lipoprotein receptor-related protein", "gene_name": "Lrp6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lrp6", "gene_names_refseq": "", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "tooth agenesis (Disease Ontology:DOID:0050591); neural tube defect (Disease Ontology:DOID:0080074); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:312781); (R-RNO-3772470); (R-RNO-4641262); (R-RNO-4641263)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in various processes including retinal angiogenesis and bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, 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dry eye syndrome (Disease Ontology:DOID:10140); otitis media (Disease Ontology:DOID:10754); gastric ulcer (Disease Ontology:DOID:10808); Sjogren's syndrome (Disease Ontology:DOID:12894); angle-closure glaucoma (Disease Ontology:DOID:13550); cystic fibrosis (Disease Ontology:DOID:1485); cystitis (Disease Ontology:DOID:1679); glaucoma (Disease Ontology:DOID:1686); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); mucinous adenocarcinoma (Disease Ontology:DOID:3030); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); pulmonary fibrosis (Disease Ontology:DOID:3770); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); common bile duct neoplasm (Disease Ontology:DOID:4608); cholangiocarcinoma (Disease Ontology:DOID:4947); stomach disease (Disease Ontology:DOID:76); corneal ulcer (Disease Ontology:DOID:8463); keratoconjunctivitis (Disease Ontology:DOID:9368)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0070701 mucus layer;GO:0005615 extracellular space", "go_biological_process": "GO:0010477 response to sulfur dioxide;GO:0030855 epithelial cell differentiation;GO:0032496 response to lipopolysaccharide;GO:0071300 cellular response to retinoic acid;GO:0033189 response to vitamin A", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K1Y4-1", "record_type": "protein", "filter_code": "0000000.1000010.001000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K222-1", "uniprot_id": [ { "id": "A0A0G2K222_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K222", "type": "external" } ], "mass": 78737.0, "length": 702, "protein_name": "mRNA export factor GLE1", "gene_name": "Gle1-ps1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gle1-ps1", "gene_names_refseq": "", "protein_names_uniprotkb": "mRNA export factor GLE1; 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"length": 986, "protein_name": "Isoleucine--tRNA ligase, mitochondrial", "gene_name": "Iars2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Iars2", "gene_names_refseq": "", "protein_names_uniprotkb": "Isoleucine--tRNA ligase, mitochondrial; 6.1.1.5; Isoleucyl-tRNA synthetase", "protein_names_refseq": "", "tax_id": 10116, "disease": "mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (R-RNO-9837999)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Aminoacyl-tRNA synthetase that catalyzes the specific attachment of isoleucine to its cognate tRNA (tRNA(Ile))., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, 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"type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": 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"external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0004822 isoleucine-tRNA 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It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005507 copper ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031091 platelet alpha granule", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation;GO:0008015 blood circulation;GO:0031638 zymogen activation;GO:0032571 response to vitamin K", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2K3W2-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K3Z9-1", "uniprot_id": [ { "id": "A0A0G2K3Z9_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K3Z9", "type": "external" } ], "mass": 22164.0, "length": 199, "protein_name": "Peroxiredoxin-1", "gene_name": "Prdx1l1", "organism": "Rat", "refseq_name": "peroxiredoxin 1-like 1", "refseq_ac": [ { "id": "NP_001395737", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001395737", "type": "external" } ], "gene_names_uniprotkb": "Prdx1l1", "gene_names_refseq": "AABR07012795.1; Prdx1l1", "protein_names_uniprotkb": "Peroxiredoxin-1; 1.11.1.24", "protein_names_refseq": "peroxiredoxin 1-like 1; peroxiredoxin-1-like", "tax_id": 10116, "disease": "methylmalonic aciduria and homocystinuria type cblC (Disease Ontology:DOID:0050715)", "pathway": " (rno:100363379)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34502162", "class_list": "", "function": "Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0008379 thioredoxin peroxidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0045454 cell redox homeostasis;GO:0019430 removal of superoxide radicals;GO:0042744 hydrogen peroxide catabolic process;GO:0045321 leukocyte activation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0G2K3Z9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K435-1", "uniprot_id": [ { "id": "A0A0G2K435_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K435", "type": "external" } ], "mass": 65528.0, "length": 579, "protein_name": "DnaJ homolog subfamily C member 7", "gene_name": "Dnajc7", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily C member 7 isoform X1", "refseq_ac": [ { "id": "XP_006247373", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006247373", "type": "external" } ], "gene_names_uniprotkb": "Dnajc7", "gene_names_refseq": "CCRP; Dnajc7", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 7", "protein_names_refseq": "dnaJ homolog subfamily C member 7 isoform X1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005634 nucleus", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K435-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K469-1", "uniprot_id": [ { "id": "A0A0G2K469_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K469", "type": "external" } ], "mass": 36785.0, "length": 323, "protein_name": "Olfactory receptor", "gene_name": "Or7g34b; Or7g34", "organism": "Rat", "refseq_name": "olfactory receptor Olr1149", "refseq_ac": [ { "id": "NP_001000874", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000874", "type": "external" } ], "gene_names_uniprotkb": "Or7g34b; Or7g34; Or7g34", "gene_names_refseq": "Olr1149; Or7g34", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1149; olfactory receptor Olr1149; olfactory receptor gene Olr1149", "tax_id": 10116, "disease": "", "pathway": " (rno:405172)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K469-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K470-1", "uniprot_id": [ { "id": "A0A0G2K470_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K470", "type": "external" } ], "mass": 128839.0, "length": 1178, "protein_name": "Integrin alpha-2", "gene_name": "Itga2", "organism": "Rat", "refseq_name": "integrin alpha-2 precursor", "refseq_ac": [ { "id": "NP_001414220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414220", "type": "external" } ], "gene_names_uniprotkb": "Itga2", "gene_names_refseq": "CD49B; GPIa; HPA-5; Itga2", "protein_names_uniprotkb": "Integrin alpha-2; CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; VLA-2 subunit alpha", "protein_names_refseq": "integrin alpha 2; integrin alpha-2 precursor; platelet glycoprotein Ia", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); von Willebrand's disease 1 (Disease Ontology:DOID:0060573); von Willebrand's disease 2 (Disease Ontology:DOID:0060574); thrombosis (Disease Ontology:DOID:0060903); sensorineural hearing loss (Disease Ontology:DOID:10003); iron deficiency anemia (Disease Ontology:DOID:11758); Behcet's disease (Disease Ontology:DOID:13241); thrombocytopenia (Disease Ontology:DOID:1588); retinal vein occlusion (Disease Ontology:DOID:1727); Glanzmann's thrombasthenia (Disease Ontology:DOID:2219); arteriosclerosis (Disease Ontology:DOID:2349); placental insufficiency (Disease Ontology:DOID:3891); myocardial infarction (Disease Ontology:DOID:5844); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:170921); (R-RNO-216083); (R-RNO-3000170); (R-RNO-3000178); (R-RNO-8874081)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "27169768;27827993;29023021;31964805", "class_list": "", "function": "Bone marrow-mesenchymal stem cell treatment was able to accelerate the healing process of burns by increasing the thickness of the collagen and the percentage of integrin alpha2beta1, thus accelerating the cell migration involved during wound healing., [RefSeq, PubMed]; Ca(2+) waves coordinate purinergic receptor-evoked integrin activation and polarization. Publication Status: Online-Only, [RefSeq, PubMed]; Hydrostatic mechanical force enhances the viability and decreases the apoptosis of condylar chondrocytes through integrin-FAK-ERK/PI3K pathway. 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In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell., [UniProtKB, UniProtKB]; In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005675 transcription factor TFIIH holo complex;GO:0000439 transcription factor TFIIH core complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006294 nucleotide-excision repair, preincision complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K606-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K652-1", "uniprot_id": [ { "id": "A0A0G2K652_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K652", "type": "external" } ], "mass": 283665.0, "length": 2541, "protein_name": "Cullin-9", "gene_name": "Cul9", "organism": "Rat", "refseq_name": "cullin-9 isoform X1", "refseq_ac": [ { "id": "XP_038939436", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038939436", "type": "external" } ], "gene_names_uniprotkb": "Cul9", "gene_names_refseq": "Cul9; Parc; RGD1562008", "protein_names_uniprotkb": "Cullin-9; p53-associated parkin-like cytoplasmic protein", "protein_names_refseq": "cullin-9 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-8951664)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0016740 transferase activity;GO:0160072 ubiquitin ligase complex scaffold activity", "go_cellular_component": "GO:0031467 Cul7-RING ubiquitin ligase complex;GO:0005737 cytoplasm;GO:0031461 cullin-RING ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0000226 microtubule cytoskeleton organization;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0007088 regulation of mitotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2K652-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K654-1", "uniprot_id": [ { "id": "A0A0G2K654_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K654", "type": "external" } ], "mass": 21317.0, "length": 212, "protein_name": "H1.2 linker histone, cluster member", "gene_name": "H1f2", "organism": "Rat", "refseq_name": "H1.2 linker histone, cluster member", "refseq_ac": [ { "id": "NP_001395696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001395696", "type": "external" } ], "gene_names_uniprotkb": "H1f2", "gene_names_refseq": "H1f2; Hist1h1c", "protein_names_uniprotkb": "H1.2 linker histone, cluster member", "protein_names_refseq": "H1.2 linker histone, cluster member; histone H1.2; histone cluster 1 H1 family member c; histone cluster 1, H1c", "tax_id": 10116, "disease": "acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:684681)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34502162;38843836", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0031490 chromatin DNA binding;GO:0061628 histone H3K27me3 reader activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000791 euchromatin;GO:0000792 heterochromatin", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination;GO:0048024 regulation of mRNA splicing, via spliceosome;GO:0140718 facultative heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A0G2K654-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K6G0-1", "uniprot_id": [ { "id": "A0A0G2K6G0_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K6G0", "type": "external" } ], "mass": 34780.0, "length": 314, "protein_name": "Olfactory receptor", "gene_name": "Or5p78", "organism": "Rat", "refseq_name": "olfactory receptor Olr271", "refseq_ac": [ { "id": "NP_001000732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000732", "type": "external" } ], "gene_names_uniprotkb": "Or5p78; Olr271-ps1; RGD1564933", "gene_names_refseq": "Olr271; Or5p78", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 271; olfactory receptor Olr271; olfactory receptor gene Olr271", "tax_id": 10116, "disease": "", "pathway": " (rno:404988)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K6G0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K6I6-1", "uniprot_id": [ { "id": "A0A0G2K6I6_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K6I6", "type": "external" } ], "mass": 51048.0, "length": 454, "protein_name": "Tubulin delta chain", "gene_name": "Tubd1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tubd1", "gene_names_refseq": "", "protein_names_uniprotkb": "Tubulin delta chain; Delta-tubulin", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:287592)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a positive regulator of hedgehog signaling and regulates ciliary function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005929 cilium", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0000278 mitotic cell cycle;GO:0007010 cytoskeleton organization;GO:0000226 microtubule cytoskeleton organization;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K6I6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K6J6-1", "uniprot_id": [ { "id": "A0A0G2K6J6_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K6J6", "type": "external" } ], "mass": 117022.0, "length": 1009, "protein_name": "Importin 8", "gene_name": "Ipo8", "organism": "Rat", "refseq_name": "importin-8", "refseq_ac": [ { "id": "NP_001387811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001387811", "type": "external" } ], "gene_names_uniprotkb": "Ipo8", "gene_names_refseq": "AABR07062570.1; Ipo8", "protein_names_uniprotkb": "Importin 8", "protein_names_refseq": "importin-8", "tax_id": 10116, "disease": "", "pathway": " (rno:686774); (R-RNO-5578749)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "25968067", "class_list": "", "function": "MAPK-specific inhibitors 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"reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005829 cytosol;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006606 protein import into nucleus;GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2K6J6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K6L2-1", "uniprot_id": [ { "id": "A0A0G2K6L2_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K6L2", "type": "external" } ], "mass": 12484.0, "length": 114, 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"reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005507 copper ion binding;GO:0004322 ferroxidase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K8Q3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K904-1", "uniprot_id": [ { "id": "A0A0G2K904_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K904", "type": "external" } ], "mass": 117168.0, "length": 1034, "protein_name": "SAFB-like transcription modulator", "gene_name": "Sltm", "organism": "Rat", "refseq_name": "SAFB-like, transcription modulator isoform 1", "refseq_ac": [ { "id": "NP_001417208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001417208", "type": "external" } ], "gene_names_uniprotkb": "Sltm", "gene_names_refseq": "RGD1307526; Sltm", "protein_names_uniprotkb": "SAFB-like transcription modulator; Modulator of estrogen-induced transcription", "protein_names_refseq": "SAFB-like, transcription modulator isoform 1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2K904-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PSL7-1", "uniprot_id": [ { "id": "CTRO_RAT", "url": "https://www.uniprot.org/uniprot/E9PSL7", "type": "external" } ], "mass": 235310.0, "length": 2055, "protein_name": "Citron rho-interacting kinase", "gene_name": "Cit", "organism": "Rat", "refseq_name": "citron rho-interacting kinase", "refseq_ac": [ { "id": "NP_001025082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025082", "type": "external" } ], "gene_names_uniprotkb": "Cit; CRIK", "gene_names_refseq": "CRIK; Cit", "protein_names_uniprotkb": "Citron rho-interacting kinase; 2.7.11.1; CRIK; Rho-interacting, serine/threonine-protein kinase 21", "protein_names_refseq": "citron (rho-interacting, serine/threonine kinase 21); citron kinase; citron rho-interacting kinase; citron-K kinase; postsynaptic density protein (citron); rho-interacting, serine/threonine-protein kinase 21", "tax_id": 10116, "disease": "primary autosomal recessive microcephaly 17 (Disease Ontology:DOID:0070288); primary microcephaly (Disease Ontology:DOID:0070297); traumatic brain injury (Disease Ontology:DOID:0081292); microcephaly (Disease Ontology:DOID:10907); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:83620); (R-RNO-5625900); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013149)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "20971191;22673903;24695496;25593024", "class_list": "", "function": "CitK is not required for a subset of RPCs before E14, but is necessary for RPC survival post E14. Publication Status: Online-Only, [RefSeq, PubMed]; Citron-K regulates actin polymerization downstream of RhoA and may offer a potentially novel therapeutic approach for promoting central nervous system axon regeneration., [RefSeq, PubMed]; Plays a role in cytokinesis (By similarity). Required for KIF14 localization to the central spindle and midbody (By similarity). Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1 (By similarity). It probably binds p21 with a tighter specificity in vivo (By similarity). Displays serine/threonine protein kinase activity (By similarity). Plays an important role in the regulation of cytokinesis and the development of the central nervous system (PubMed:24695496). Phosphorylates MYL9/MLC2 (By similarity)., [UniProtKB, PubMed, UniProtKB]; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2JWA9;Q9QX19", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0043025 neuronal cell body", "go_biological_process": "GO:0008064 regulation of actin polymerization or depolymerization;GO:0000278 mitotic cell cycle;GO:0001889 liver development;GO:0007283 spermatogenesis;GO:0016358 dendrite development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E9PSL7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZS28-1", "uniprot_id": [ { "id": "RBL1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZS28", "type": "external" } ], "mass": 117818.0, "length": 1049, "protein_name": "Retinoblastoma-like protein 1", "gene_name": "Rbl1", "organism": "Rat", "refseq_name": "retinoblastoma-like protein 1", "refseq_ac": [ { "id": "NP_001177995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177995", "type": "external" } ], "gene_names_uniprotkb": "Rbl1", "gene_names_refseq": "Rbl1; p107; pRb1", "protein_names_uniprotkb": "Retinoblastoma-like protein 1; 107 kDa retinoblastoma-associated protein; p107; pRb1", "protein_names_refseq": "107 kDa retinoblastoma-associated protein; retinoblastoma-like 1 (p107); retinoblastoma-like protein 1", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); intellectual disability (Disease Ontology:DOID:1059); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:680111); (R-RNO-1538133); (R-RNO-2173796); (R-RNO-69231)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "22673903;23716589;23775125;9697699", "class_list": "", "function": "Fibroblast growth factor 1, which induces maturation and cell cycle exit in chondrocytes, triggers rapid accumulation of retinoblastoma-like 1 (p107)-PP2A/B55-alpha complexes coinciding with retinoblastoma-like 1 (p107) dephosphorylation., [RefSeq, PubMed]; Key regulator of entry into cell division (By similarity). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation. May act as a tumor suppressor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. May act as a tumor suppressor., [UniProtKB, UniProtKB, UniProtKB]; Only the B55alpha(55-kDa regulatory subunit, alpha isoform) regulatory subunit of PP2A was able to bind retinoblastoma-like 1 (p107), and this interaction was induced by fibroblast growth factor 1 in chondrocytes but not in other cell types., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:2000773 negative regulation of cellular senescence", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3ZS28-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A135-1", "uniprot_id": [ { "id": "D4A135_RAT", "url": "https://www.uniprot.org/uniprot/D4A135", "type": "external" } ], "mass": 78302.0, "length": 684, "protein_name": "GRAM domain containing 1C", "gene_name": "Gramd1c", "organism": "Rat", "refseq_name": "protein Aster-C isoform X1", "refseq_ac": [ { "id": "XP_038944410", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038944410", "type": "external" } ], "gene_names_uniprotkb": "Gramd1c", "gene_names_refseq": "Gramd1c; RGD1305433", "protein_names_uniprotkb": "GRAM domain containing 1C", "protein_names_refseq": "protein Aster-C isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:360717)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0015485 cholesterol binding;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0044232 organelle membrane contact site;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane;GO:0005886 plasma membrane;GO:0140268 endoplasmic reticulum-plasma membrane contact site", "go_biological_process": "GO:0032366 intracellular sterol transport;GO:0071397 cellular response to cholesterol", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A135-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3D4-1", "uniprot_id": [ { "id": "D4A3D4_RAT", "url": "https://www.uniprot.org/uniprot/D4A3D4", "type": "external" } ], "mass": 60361.0, "length": 543, "protein_name": "Phospholipase ABHD3", "gene_name": "Abhd3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Abhd3", "gene_names_refseq": "", "protein_names_uniprotkb": "Phospholipase ABHD3; 3.1.1.32; 3.1.1.4; Abhydrolase domain-containing protein 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-1483191)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" } ], "go_molecular_function": "GO:0004623 phospholipase A2 activity;GO:0008970 phospholipase A1 activity;GO:0047372 monoacylglycerol lipase activity;GO:0008126 acetylesterase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0046470 phosphatidylcholine metabolic process;GO:0051793 medium-chain fatty acid catabolic process;GO:0051792 medium-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A3D4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZU07-1", "uniprot_id": [ { "id": "D3ZU07_RAT", "url": "https://www.uniprot.org/uniprot/D3ZU07", "type": "external" } ], "mass": 82259.0, "length": 705, "protein_name": "Translin-associated factor X interacting protein 1", "gene_name": "Tsnaxip1", "organism": "Rat", "refseq_name": "translin-associated factor X-interacting protein 1", "refseq_ac": [ { "id": "NP_001102600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102600", "type": "external" } ], "gene_names_uniprotkb": "Tsnaxip1", "gene_names_refseq": "RGD1565341; Tsnaxip1", "protein_names_uniprotkb": "Translin-associated factor X interacting protein 1", "protein_names_refseq": "translin-associated factor X (Tsnax) interacting protein 1; translin-associated factor X-interacting protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:498944)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZU07-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZTT7-1", "uniprot_id": [ { "id": "D3ZTT7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZTT7", "type": "external" } ], "mass": 80312.0, "length": 720, "protein_name": "Sad1 and UNC84 domain containing 2", "gene_name": "Sun2", "organism": "Rat", "refseq_name": "SUN domain-containing protein 2 isoform X1", "refseq_ac": [ { "id": "XP_006242109", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006242109", "type": "external" } ], "gene_names_uniprotkb": "Sun2", "gene_names_refseq": "RGD1563141; Sun2; Unc84b", "protein_names_uniprotkb": "Sad1 and UNC84 domain containing 2", "protein_names_refseq": "SUN domain-containing protein 2 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:315135)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005521 lamin binding;GO:0140444 cytoskeleton-nuclear membrane anchor activity", "go_cellular_component": "GO:0005637 nuclear inner membrane;GO:0000781 chromosome, telomeric region;GO:0000794 condensed nuclear chromosome;GO:0005635 nuclear envelope;GO:0031965 nuclear membrane", "go_biological_process": "GO:0021817 nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration;GO:0051321 meiotic cell cycle;GO:0051642 centrosome localization;GO:0031022 nuclear migration along microfilament;GO:0090292 nuclear matrix anchoring at nuclear membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZTT7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A198-1", "uniprot_id": [ { "id": "D4A198_RAT", "url": "https://www.uniprot.org/uniprot/D4A198", "type": "external" } ], "mass": 167539.0, "length": 1563, "protein_name": "Neuralized-like protein 4", "gene_name": "Neurl4", "organism": "Rat", "refseq_name": "neuralized-like protein 4 isoform 1", "refseq_ac": [ { "id": "NP_001401280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401280", "type": "external" } ], "gene_names_uniprotkb": "Neurl4", "gene_names_refseq": "Gps2l; Neurl4", "protein_names_uniprotkb": "Neuralized-like protein 4", "protein_names_refseq": "neuralized homolog 4; neuralized-like protein 4 isoform 1; neuralized-like protein 4", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0061630 ubiquitin protein ligase activity;GO:0030701 NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity", "go_cellular_component": "GO:0005814 centriole;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0007283 spermatogenesis;GO:0043504 mitochondrial DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A198-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DFA5-1", "uniprot_id": [ { "id": "B5DFA5_RAT", "url": "https://www.uniprot.org/uniprot/B5DFA5", "type": "external" } ], "mass": 58111.0, "length": 502, "protein_name": "Protein O-glucosyltransferase 2", "gene_name": "Poglut2", "organism": "Rat", "refseq_name": "protein O-glucosyltransferase 2 precursor", "refseq_ac": [ { "id": "NP_001264157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264157", "type": "external" } ], "gene_names_uniprotkb": "Poglut2; Kdelc1", "gene_names_refseq": "Kdelc1; Poglut2", "protein_names_uniprotkb": "Protein O-glucosyltransferase 2", "protein_names_refseq": "KDEL (Lys-Asp-Glu-Leu) containing 1; KDEL motif containing 1; KDEL motif-containing protein 1; protein O-glucosyltransferase 2 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:316370)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F7FHZ5", "ec_number_list": [ { "id": "2.4.1.376", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.376", "type": "external" }, { "id": "2.4.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.63", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0035252 UDP-xylosyltransferase activity;GO:0035251 UDP-glucosyltransferase activity;GO:0046527 glucosyltransferase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005788 endoplasmic reticulum lumen;GO:0012505 endomembrane system", "go_biological_process": "GO:0180059 protein O-linked glycosylation via glucose", "synthesized_glycan_count": 6710, "hit_score": 0.1, "record_id": "B5DFA5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZHK4-1", "uniprot_id": [ { "id": "D3ZHK4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZHK4", "type": "external" } ], "mass": 182228.0, "length": 1588, "protein_name": "RB1-inducible coiled-coil protein 1", "gene_name": "Rb1cc1", "organism": "Rat", "refseq_name": "RB1-inducible coiled-coil protein 1", "refseq_ac": [ { "id": "NP_001101371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101371", "type": "external" } ], "gene_names_uniprotkb": "Rb1cc1", "gene_names_refseq": "Rb1cc1", "protein_names_uniprotkb": "RB1-inducible coiled-coil protein 1; FAK family kinase-interacting protein of 200 kDa", "protein_names_refseq": "RB1-inducible coiled-coil protein 1", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (rno:312927); (R-RNO-1632852)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0060090 molecular adaptor activity;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005764 lysosome;GO:0031090 organelle membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0001889 liver development;GO:0001934 positive regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZHK4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A0G7-1", "uniprot_id": [ { "id": "D4A0G7_RAT", "url": "https://www.uniprot.org/uniprot/D4A0G7", "type": "external" } ], "mass": 24660.0, "length": 223, "protein_name": "small monomeric GTPase", "gene_name": "Rab37", "organism": "Rat", "refseq_name": "RAB37, member RAS oncogene family isoform 2", "refseq_ac": [ { "id": "NP_001417256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001417256", "type": "external" } ], "gene_names_uniprotkb": "Rab37", "gene_names_refseq": "Rab37", "protein_names_uniprotkb": "small monomeric GTPase; 3.6.5.2", "protein_names_refseq": "RAB37, member RAS oncogene family isoform 2; RAB37, member of RAS oncogene family; rCG35079-like; ras-related protein Rab-37", "tax_id": 10116, "disease": "", "pathway": " (rno:100364984); (R-RNO-6798695); (R-RNO-8873719)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "26931073", "class_list": "", "function": "Results suggest that Rab37 is a Munc13-4-binding protein that inhibits mast cell degranulation through its effector protein, by counteracting the vesicle-priming activity of the Rab27-Munc13-4 system Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity;GO:0003924 GTPase activity", "go_cellular_component": "GO:0005793 endoplasmic reticulum-Golgi intermediate compartment;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0030141 secretory granule;GO:0032391 photoreceptor connecting cilium", "go_biological_process": "GO:0015031 protein transport;GO:0010508 positive regulation of autophagy;GO:0017157 regulation of exocytosis;GO:0042478 regulation of eye photoreceptor cell development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A0G7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZXL0-1", "uniprot_id": [ { "id": "D3ZXL0_RAT", "url": "https://www.uniprot.org/uniprot/D3ZXL0", "type": "external" } ], "mass": 74507.0, "length": 690, "protein_name": "Solute carrier family 26, member 10", "gene_name": "Slc26a10", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc26a10", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 26, member 10", 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"reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015106 bicarbonate transmembrane transporter activity;GO:0015108 chloride transmembrane transporter activity;GO:0019531 oxalate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:1902476 chloride transmembrane transport;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZXL0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PU02-1", "uniprot_id": [ { "id": "E9PU02_RAT", "url": "https://www.uniprot.org/uniprot/E9PU02", "type": "external" } ], "mass": 127422.0, "length": 1139, "protein_name": "Trafficking protein particle complex subunit 9", "gene_name": "Trappc9", "organism": "Rat", "refseq_name": "trafficking protein particle complex subunit 9", "refseq_ac": [ { "id": "NP_001029328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029328", "type": "external" } ], "gene_names_uniprotkb": "Trappc9", "gene_names_refseq": "Nibp; RGD1309461; Trappc9", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 9", "protein_names_refseq": "NIK and IKK(beta) binding protein; NIK and IKK{beta} binding protein; trafficking protein particle complex 9; trafficking protein particle complex subunit 9", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 13 (Disease Ontology:DOID:0081098); intellectual disability (Disease Ontology:DOID:1059); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (rno:315059); (R-RNO-204005); (R-RNO-8876198)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005737 cytoplasm;GO:0005802 trans-Golgi network;GO:0030008 TRAPP complex", "go_biological_process": "GO:0021987 cerebral cortex development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E9PU02-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A6T9-1", 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"function": "High MARK4 is associated with Alzheimer's disease., [RefSeq, PubMed]; Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification., [RefSeq, PubMed]; MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, 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"url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0008093 cytoskeletal anchor activity;GO:0050321 tau-protein kinase activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0030425 dendrite;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0001764 neuron migration;GO:0006468 protein phosphorylation;GO:0007399 nervous system development;GO:0035556 intracellular signal transduction;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D4A6T9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZS19-1", "uniprot_id": [ { "id": "D3ZS19_RAT", "url": "https://www.uniprot.org/uniprot/D3ZS19", "type": "external" } ], "mass": 162475.0, "length": 1458, "protein_name": "Alpha-2-macroglobulin-like 1", "gene_name": "A2ml1", "organism": "Rat", "refseq_name": "alpha-2-macroglobulin-like 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001418713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001418713", "type": "external" } ], "gene_names_uniprotkb": "A2ml1; RGD1565709", "gene_names_refseq": "A2ml1; RGD1565709", "protein_names_uniprotkb": "Alpha-2-macroglobulin-like 1", "protein_names_refseq": "alpha-2-macroglobulin-like 1 isoform 1 precursor; ovostatin homolog", "tax_id": 10116, 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"ATP-dependent chromatin remodeler CHD4", "gene_name": "Chd4", "organism": "Rat", "refseq_name": "chromodomain-helicase-DNA-binding protein 4 isoform X3", "refseq_ac": [ { "id": "XP_006237463", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006237463", "type": "external" } ], "gene_names_uniprotkb": "Chd4", "gene_names_refseq": "Chd4; Mi-2", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD4; Chromo domain-containing protein 4", "protein_names_refseq": "chromodomain-helicase-DNA-binding protein 4 isoform X3", "tax_id": 10116, "disease": "lymphoma (Disease Ontology:DOID:0060058); left ventricular noncompaction (Disease Ontology:DOID:0060480); Sifrim-Hitz-Weiss syndrome (Disease Ontology:DOID:0070529); lung cancer (Disease Ontology:DOID:1324); rectum cancer (Disease Ontology:DOID:1993); colon adenocarcinoma (Disease Ontology:DOID:234); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-RNO-3214815); (R-RNO-6804758); (R-RNO-73762); (R-RNO-8943724); (R-RNO-9031628); (R-RNO-9937850); (R-RNO-9940465); (R-RNO-9940951)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination. Involved in neurogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, 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"https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0072553 terminal button organization;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010629 negative 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Required to stabilize the pericentriolar material (PCM)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0008289 lipid binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005814 centriole", "go_biological_process": "GO:0007018 microtubule-based movement;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2K9Y3-1", "record_type": "protein", "filter_code": "0000000.0000100.000100.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZWD1-1", "uniprot_id": [ { "id": "D3ZWD1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZWD1", "type": "external" } ], "mass": 87731.0, "length": 791, "protein_name": "Leucine rich repeats and calponin homology domain containing 3", "gene_name": "Lrch3", "organism": "Rat", "refseq_name": "DISP complex protein LRCH3 isoform X1", "refseq_ac": [ { "id": "XP_038944252", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038944252", "type": "external" } ], "gene_names_uniprotkb": "Lrch3", "gene_names_refseq": "Lrch3", "protein_names_uniprotkb": "Leucine rich repeats and calponin homology domain containing 3", "protein_names_refseq": "DISP complex protein LRCH3 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:303883)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0032185 septin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZWD1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQ46-1", "uniprot_id": [ { "id": "D3ZQ46_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQ46", "type": "external" } ], "mass": 23703.0, "length": 213, "protein_name": "CKLF-like MARVEL transmembrane domain containing 5", "gene_name": "Cmtm5", "organism": "Rat", "refseq_name": "CKLF-like MARVEL transmembrane domain-containing protein 5 isoform X3", "refseq_ac": [ { "id": "XP_063130192", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063130192", "type": "external" } ], "gene_names_uniprotkb": "Cmtm5", "gene_names_refseq": "Cklfsf5; 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(R-RNO-212436); (R-RNO-9843940)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]; May have a role during differentiation processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A171-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B6RHI6-1", "uniprot_id": [ { "id": "B6RHI6_RAT", "url": "https://www.uniprot.org/uniprot/B6RHI6", "type": "external" } ], "mass": 80178.0, "length": 728, "protein_name": "E3 ubiquitin-protein ligase LNX", "gene_name": "Lnx1", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase LNX", "refseq_ac": [ { "id": "NP_001101828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101828", "type": "external" } ], "gene_names_uniprotkb": "Lnx1", "gene_names_refseq": "Lnx1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase LNX; 2.3.2.27; Numb-binding protein 1; RING-type E3 ubiquitin transferase LNX", "protein_names_refseq": "E3 ubiquitin-protein ligase LNX; ligand of numb-protein X 1, E3 ubiquitin protein ligase", "tax_id": 10116, "disease": "", "pathway": " (rno:360926); (R-RNO-983168)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "31628376", "class_list": "", "function": "E3 ubiquitin ligases LNX1 and LNX2 are major regulators of the presynaptic glycine transporter GlyT2. Publication Status: Online-Only, [RefSeq, PubMed]; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Isoform 2 provides an endocytic scaffold for IGSF5/JAM4., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, 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LSM5; Lsm5l1", "gene_names_refseq": "", "protein_names_uniprotkb": "U6 snRNA-associated Sm-like protein LSm5", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:306222); (R-RNO-430039)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0071011 precatalytic spliceosome;GO:0120115 Lsm2-8 complex", "go_biological_process": "GO:0009617 response to bacterium;GO:0006402 mRNA catabolic process;GO:0000398 mRNA splicing, via spliceosome;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZBJ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZBU5-1", "uniprot_id": [ { "id": "D3ZBU5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZBU5", "type": "external" } ], "mass": 132112.0, "length": 1223, "protein_name": "ALF transcription elongation factor 1", "gene_name": "Aff1", "organism": "Rat", "refseq_name": "AF4/FMR2 family member 1 isoform 1", "refseq_ac": [ { "id": "NP_001424035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001424035", "type": "external" } ], "gene_names_uniprotkb": "Aff1", "gene_names_refseq": "Aff1; 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3.6.4.13", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:300710)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilizing its protein level. Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression., [UniProtKB, UniProtKB]; RNA helicase., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, 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"https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006364 rRNA processing;GO:0097065 anterior head development", "synthesized_glycan_count": 0, "hit_score": 0.2, 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polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0002067 glandular epithelial cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZCL0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZCQ2-1", "uniprot_id": [ { "id": "D3ZCQ2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZCQ2", "type": "external" } ], "mass": 55382.0, "length": 492, "protein_name": "GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase", "gene_name": "Alg11", "organism": "Rat", "refseq_name": "GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase", "refseq_ac": [ { "id": "NP_001101871", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101871", "type": "external" } ], "gene_names_uniprotkb": "Alg11", "gene_names_refseq": "Alg11; RGD1564725", "protein_names_uniprotkb": "GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; 2.4.1.131", "protein_names_refseq": "GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; asparagine-linked glycosylation 11 homolog (S. cerevisiae, alpha-1,2-mannosyltransferase); asparagine-linked glycosylation 11 homolog (yeast, alpha-1,2-mannosyltransferase); asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog; asparagine-linked glycosylation protein 11 homolog", "tax_id": 10116, "disease": "congenital disorder of glycosylation Ip (Disease Ontology:DOID:0080567)", "pathway": " (rno:361174)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide. Man(5)GlcNAc(2)-PP-dolichol is a substrate for ALG3, the following enzyme in the biosynthetic pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.131", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.131", "type": "external" } ], "go_molecular_function": "GO:0004377 GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 781, "hit_score": 0.1, "record_id": "D3ZCQ2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZCX6-1", "uniprot_id": [ { "id": "D3ZCX6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZCX6", "type": "external" } ], "mass": 129258.0, "length": 1197, "protein_name": "RNA exonuclease 1 homolog", "gene_name": "Rexo1", "organism": "Rat", "refseq_name": "RNA exonuclease 1 homolog", "refseq_ac": [ { "id": "NP_001012114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012114", "type": "external" } ], "gene_names_uniprotkb": "Rexo1", "gene_names_refseq": "Rexo1; Tceb3bp1", "protein_names_uniprotkb": "RNA exonuclease 1 homolog", "protein_names_refseq": "REX1, RNA exonuclease 1 homolog; RNA exonuclease 1 homolog; transcription elongation factor B polypeptide 3 binding protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:314630)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0004527 exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0031125 rRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZCX6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZCY9-1", "uniprot_id": [ { "id": "D3ZCY9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZCY9", "type": "external" } ], "mass": 35199.0, "length": 315, "protein_name": "Olfactory receptor", "gene_name": "Or8b3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Or8b3", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:300560)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZCY9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZCZ3-1", "uniprot_id": [ { "id": "D3ZCZ3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZCZ3", "type": "external" } ], "mass": 15573.0, "length": 145, "protein_name": "Cystin 1", "gene_name": "Cys1", "organism": "Rat", "refseq_name": "cystin-1", "refseq_ac": [ { "id": "NP_001103067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103067", "type": "external" } ], "gene_names_uniprotkb": "Cys1", "gene_names_refseq": "Cys1", "protein_names_uniprotkb": "Cystin 1", "protein_names_refseq": "cystin-1", "tax_id": 10116, "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); 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"0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZDY4-1", "uniprot_id": [ { "id": "D3ZDY4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZDY4", "type": "external" } ], "mass": 10517.0, "length": 92, "protein_name": "C-C motif chemokine", "gene_name": "Ccl1", "organism": "Rat", "refseq_name": "C-C motif chemokine 1 precursor", "refseq_ac": [ { "id": "NP_001178021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178021", "type": "external" } ], "gene_names_uniprotkb": "Ccl1", "gene_names_refseq": "Ccl1", "protein_names_uniprotkb": "C-C motif chemokine", "protein_names_refseq": "C-C motif chemokine 1 precursor; C-C motif chemokine 1; chemokine (C-C motif) ligand 1", "tax_id": 10116, "disease": "multiple sclerosis (Disease Ontology:DOID:2377); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); pulmonary tuberculosis (Disease 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leukocyte receptor cluster member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:292535); (R-RNO-72163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZER8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZEZ3-1", "uniprot_id": [ { "id": "D3ZEZ3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZEZ3", "type": "external" } ], "mass": 30687.0, "length": 289, "protein_name": "Dehydrogenase/reductase SDR family member 4", "gene_name": "Dhrs2", "organism": "Rat", "refseq_name": "dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1", "refseq_ac": [ { "id": "XP_001078405", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001078405", "type": "external" } ], "gene_names_uniprotkb": "Dhrs2", "gene_names_refseq": "Dhrs2", "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 4; 1.1.1.184; 1.1.1.300; NADPH-dependent carbonyl reductase; NADPH-dependent retinol dehydrogenase/reductase; Peroxisomal short-chain alcohol dehydrogenase; Short chain dehydrogenase/reductase family 25C member 2", "protein_names_refseq": "dehydrogenase/reductase SDR family member 2, mitochondrial isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:691464)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Reduces all-trans-retinal and 9-cis retinal. Reduces 3-ketosteroids and benzil into 3alpha-hydroxysteroids and S-benzoin, respectively, in contrast to the stereoselectivity of primates DHRS4s which produce 3beta-hydroxysteroids and R-benzoin. In the reverse reaction, catalyzes the NADP-dependent oxidation of 3alpha-hydroxysteroids and alcohol, but with much lower efficiency. Involved in the metabolism of 3alpha-hydroxysteroids, retinoid, isatin and xenobiotic carbonyl compounds., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.122", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.122", "type": "external" }, { "id": "1.6.5.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.104", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.189", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.189", "type": "external" }, { "id": "1.1.1.197", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.197", "type": "external" }, { "id": "1.1.1.196", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.196", "type": "external" }, { "id": "1.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.71", "type": "external" } ], "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity;GO:0004090 carbonyl reductase (NADPH) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0009636 response to toxic substance;GO:0034599 cellular response to oxidative stress;GO:0043011 myeloid dendritic cell differentiation;GO:0022900 electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZEZ3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZF03-1", "uniprot_id": [ { "id": "D3ZF03_RAT", "url": "https://www.uniprot.org/uniprot/D3ZF03", "type": "external" } ], "mass": 66645.0, "length": 604, "protein_name": "Apoptosis-inducing factor 3", "gene_name": "Aifm3", "organism": "Rat", "refseq_name": "apoptosis-inducing factor 3", "refseq_ac": [ { "id": "NP_001013999", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013999", "type": "external" } ], "gene_names_uniprotkb": "Aifm3", "gene_names_refseq": "Aifm3; RGD1306028", "protein_names_uniprotkb": "Apoptosis-inducing factor 3; Apoptosis-inducing factor-like protein", "protein_names_refseq": "apoptosis inducing factor, mitochondria associated 3; apoptosis-inducing factor 3; apoptosis-inducing factor, mitochondrion-associated 3", "tax_id": 10116, "disease": "", "pathway": " (rno:303786)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21447364;22085972;22673903", "class_list": "", "function": "AIF participates in GM-induced apoptosis of vestibular hair cells., [RefSeq, PubMed]; Apoptosis-inducing factor is involved in apoptotic-like death of cerebellar granule neurons and could be an alternative mechanism of neuronal death during cerebellar development., [RefSeq, PubMed]; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0016651 oxidoreductase activity, acting on NAD(P)H;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0097194 execution phase of apoptosis;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZF03-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZF26-1", "uniprot_id": [ { "id": "D3ZF26_RAT", "url": "https://www.uniprot.org/uniprot/D3ZF26", "type": "external" } ], "mass": 180013.0, "length": 1705, "protein_name": "Tankyrase 1 binding protein 1", "gene_name": "Tnks1bp1", "organism": "Rat", "refseq_name": "182 kDa tankyrase-1-binding protein", "refseq_ac": [ { "id": "NP_001416791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001416791", "type": "external" } ], "gene_names_uniprotkb": "Tnks1bp1", "gene_names_refseq": "Cnot12; Tnks1bp1", "protein_names_uniprotkb": "Tankyrase 1 binding protein 1", "protein_names_refseq": "182 kDa tankyrase-1-binding protein; tankyrase 1 binding protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:295707); (R-RNO-6804115)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16641100;22673903", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0044877 protein-containing complex binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0071532 ankyrin repeat binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0000792 heterochromatin;GO:0030014 CCR4-NOT complex", "go_biological_process": "GO:0006302 double-strand break repair;GO:0071479 cellular response to ionizing radiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZF26-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZFJ8-1", "uniprot_id": [ { "id": "D3ZFJ8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZFJ8", "type": "external" } ], "mass": 14688.0, "length": 129, "protein_name": "Similar to human chromosome 3 open reading frame 22", "gene_name": "C4h3orf22", "organism": "Rat", "refseq_name": "uncharacterized protein C3orf22 homolog", "refseq_ac": [ { "id": "NP_001102959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102959", "type": "external" } ], "gene_names_uniprotkb": "C4h3orf22; LOC685964", "gene_names_refseq": "C4h3orf22", "protein_names_uniprotkb": "Similar to human chromosome 3 open reading frame 22", "protein_names_refseq": "uncharacterized protein C3orf22 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:685964)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZFJ8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZFK6-1", "uniprot_id": [ { "id": "D3ZFK6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZFK6", "type": "external" } ], "mass": 67963.0, "length": 607, "protein_name": "Autophagy-related protein 16-1", "gene_name": "Atg16l1", "organism": "Rat", "refseq_name": "autophagy-related protein 16-1", "refseq_ac": [ { "id": "NP_001102279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102279", "type": "external" } ], "gene_names_uniprotkb": "Atg16l1", "gene_names_refseq": "Apg16l; Atg16l1; Wdr30", "protein_names_uniprotkb": "Autophagy-related protein 16-1; APG16-like 1", "protein_names_refseq": "APG16 autophagy 16-like; WD repeat domain 30; autophagy-related protein 16-1", "tax_id": 10116, "disease": "inflammatory bowel disease 10 (Disease Ontology:DOID:0110885)", "pathway": " (rno:363278); (R-RNO-1632852)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12665549;22673903;33818130;33843019;35503135", "class_list": "", "function": "Functional characterization of the mouse Atg16l1 (Apg16L) ortholog., [RefSeq, PubMed]; Mutational analyses of novel rat models with targeted modifications in inflammatory bowel disease susceptibility genes., [RefSeq, PubMed]; Plasma-derived extracellular vesicles transfer microRNA-130a-3p to alleviate myocardial ischemia/reperfusion injury by targeting ATG16L1., [RefSeq, PubMed]; The Atg16l1 gene: characterization of wild type, knock-in, and knock-out phenotypes in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051020 GTPase binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0039689 negative stranded viral RNA replication;GO:0051607 defense response to virus;GO:0016236 macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D3ZFK6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZFP4-1", "uniprot_id": [ { "id": "D3ZFP4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZFP4", "type": "external" } ], "mass": 91659.0, "length": 813, "protein_name": "DNA replication licensing factor MCM3", "gene_name": "Mcm3", "organism": "Rat", "refseq_name": "DNA replication licensing factor MCM3", "refseq_ac": [ { "id": "NP_001178734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178734", "type": "external" } ], "gene_names_uniprotkb": "Mcm3", "gene_names_refseq": "Mcm3", "protein_names_uniprotkb": "DNA replication licensing factor MCM3; 3.6.4.12", "protein_names_refseq": "DNA replication licensing factor MCM3; minichromosome maintenance deficient 3", "tax_id": 10116, "disease": "", "pathway": " (rno:316273); (R-RNO-176187); (R-RNO-68867); (R-RNO-68949); (R-RNO-68962)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 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"total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZFP5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZFV3-1", "uniprot_id": [ { "id": "D3ZFV3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZFV3", "type": "external" } ], "mass": 20469.0, "length": 180, "protein_name": "FANCD2 opposite strand like 1", "gene_name": "Fancd2osl2", "organism": "Rat", "refseq_name": "uncharacterized protein LOC686031", "refseq_ac": [ { "id": "NP_001102960", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102960", "type": "external" } ], "gene_names_uniprotkb": "Fancd2osl2; Fancd2osl1; LOC134484165; LOC686042; LOC686095", "gene_names_refseq": "Fancd2osl1", "protein_names_uniprotkb": "FANCD2 opposite strand like 1", "protein_names_refseq": "uncharacterized protein LOC686031", "tax_id": 10116, "disease": "", "pathway": " (rno:686031); (rno:686042); (rno:686095)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M0R6E3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZFV3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZG09-1", "uniprot_id": [ { "id": "D3ZG09_RAT", "url": "https://www.uniprot.org/uniprot/D3ZG09", "type": "external" } ], "mass": 36621.0, "length": 319, "protein_name": "Olfactory receptor family 6 subfamily C member 208B", "gene_name": "Or6c212", "organism": "Rat", "refseq_name": "olfactory receptor Olr987", "refseq_ac": [ { "id": "NP_001000590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000590", "type": "external" } ], "gene_names_uniprotkb": "Or6c212; Olr950; Or6c208b", "gene_names_refseq": "Olr987; Or6c208b", "protein_names_uniprotkb": "Olfactory receptor family 6 subfamily C member 208B", "protein_names_refseq": "olfactory receptor 987; olfactory receptor Olr987; olfactory receptor gene Olr987", "tax_id": 10116, "disease": "", "pathway": " (rno:366810)", "pathway_count": 1, 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This activity may require prior 2'-O-methylguanosine modification at position 1370 (Gm1370) by MRM3. Essential for late-stage assembly of mtLSU required for efficient translation of mitochondrial DNA encoded proteins; methyltransferase activity is not required for this function. 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Tmem205", "protein_names_uniprotkb": "Transmembrane protein 205", "protein_names_refseq": "transmembrane protein 205", "tax_id": 10116, "disease": "", "pathway": " (rno:300441)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZJZ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZK59-1", "uniprot_id": [ { "id": "D3ZK59_RAT", "url": "https://www.uniprot.org/uniprot/D3ZK59", "type": "external" } ], "mass": 18116.0, "length": 170, "protein_name": "Keratin-associated protein", "gene_name": "LOC100363236", "organism": "Rat", "refseq_name": "keratin-associated protein 13-2-like", "refseq_ac": [ { "id": "XP_003751068", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003751068", "type": "external" } ], "gene_names_uniprotkb": "LOC100363236", "gene_names_refseq": "LOC100363236", "protein_names_uniprotkb": "Keratin-associated protein", "protein_names_refseq": "keratin-associated protein 13-2-like", "tax_id": 10116, "disease": "", "pathway": " (rno:100363236)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZK59-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZKC5-1", "uniprot_id": [ { "id": "D3ZKC5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZKC5", "type": "external" } ], "mass": 31667.0, "length": 273, "protein_name": "Sterile alpha motif domain containing 3", "gene_name": "Samd3", "organism": "Rat", "refseq_name": "sterile alpha motif domain-containing protein 3", "refseq_ac": [ { "id": "NP_001165587", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165587", "type": "external" } ], "gene_names_uniprotkb": "Samd3", "gene_names_refseq": "Samd3", "protein_names_uniprotkb": "Sterile alpha motif domain containing 3", "protein_names_refseq": "sterile alpha motif domain-containing protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:685940)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZKC5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZKD4-1", "uniprot_id": [ { "id": "D3ZKD4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZKD4", "type": "external" } ], "mass": 61383.0, "length": 556, "protein_name": "DNA replication factor Cdt1", "gene_name": "Cdt1", "organism": "Rat", "refseq_name": "DNA replication factor Cdt1", "refseq_ac": [ { "id": "NP_001099662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099662", "type": "external" } ], "gene_names_uniprotkb": "Cdt1", "gene_names_refseq": "Cdt1; Ris2", "protein_names_uniprotkb": "DNA replication factor Cdt1; Double parked homolog", "protein_names_refseq": "DNA replication factor Cdt1; retroviral integration site 2", "tax_id": 10116, "disease": "Meier-Gorlin syndrome 4 (Disease Ontology:DOID:0080515)", "pathway": " (rno:292071); (R-RNO-68867); (R-RNO-68949); (R-RNO-68962); (R-RNO-69052)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for both DNA replication and mitosis. DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC). Required also for mitosis by promoting stable kinetochore-microtubule attachments. Potential oncogene., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0070182 DNA polymerase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000776 kinetochore", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0033262 regulation of nuclear cell cycle DNA replication;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0071163 DNA replication preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZKD4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZKI3-1", "uniprot_id": [ { "id": "D3ZKI3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZKI3", "type": "external" } ], "mass": 29630.0, "length": 264, "protein_name": "Lipid transferase CIDEB", "gene_name": "Cideb", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cideb", "gene_names_refseq": "", "protein_names_uniprotkb": "Lipid transferase CIDEB; Cell death activator CIDE-B; Cell death-inducing DFFA-like effector B", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0070300 phosphatidic acid binding;GO:0120013 lipid transfer activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0031667 response to nutrient levels;GO:0034379 very-low-density lipoprotein particle assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZKI3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZKQ4-1", "uniprot_id": [ { "id": "D3ZKQ4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZKQ4", "type": "external" } ], "mass": 79002.0, "length": 718, "protein_name": "Rab-like protein 6", "gene_name": "Rabl6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rabl6", "gene_names_refseq": "", "protein_names_uniprotkb": "Rab-like protein 6; 3.6.5.2; GTP-binding protein Parf; Rab-like protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:362084)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Small GTPase involved in the regulation of cell growth and survival. Promotes cellular proliferation. May reduce growth inhibitory activity of CDKN2A., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, 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"id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZKQ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZKQ5-1", "uniprot_id": [ { "id": "D3ZKQ5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZKQ5", "type": "external" } ], "mass": 13640.0, "length": 120, "protein_name": "RIKEN cDNA 1700013D24 gene", "gene_name": "1700013D24Rikl", "organism": "Rat", "refseq_name": "uncharacterized protein LOC362433", "refseq_ac": [ { "id": "NP_001102115", "url": 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1.14.99.66; Flavin-containing amine oxidase domain-containing protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "retinoblastoma (Disease Ontology:DOID:768)", "pathway": " (R-RNO-3214842); (R-RNO-5689603)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0032453 histone H3K4 demethylase activity;GO:0008270 zinc ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0000786 nucleosome", "go_biological_process": "GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0071514 genomic imprinting;GO:0044726 epigenetic programing of female pronucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZP89-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZP99-1", "uniprot_id": [ { "id": "D3ZP99_RAT", "url": "https://www.uniprot.org/uniprot/D3ZP99", "type": "external" } ], "mass": 43832.0, "length": 409, "protein_name": "Protein phosphatase, Mg2+/Mn2+ dependent 1N", "gene_name": "Ppm1n", "organism": "Rat", "refseq_name": "probable protein phosphatase 1N isoform X1", "refseq_ac": [ { "id": "XP_038959919", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038959919", "type": "external" } ], "gene_names_uniprotkb": "Ppm1n", "gene_names_refseq": "Ppm1n; RGD1562091", "protein_names_uniprotkb": "Protein phosphatase, Mg2+/Mn2+ dependent 1N", "protein_names_refseq": "probable protein phosphatase 1N isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:292690)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0043122 regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZP99-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZPB4-1", "uniprot_id": [ { "id": "D3ZPB4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZPB4", "type": "external" } ], "mass": 35154.0, "length": 311, "protein_name": "Olfactory receptor family 1 subfamily L member 4", "gene_name": "Or1l4", "organism": "Rat", "refseq_name": "olfactory receptor Olr428", "refseq_ac": [ { "id": "NP_001000394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000394", "type": "external" } ], "gene_names_uniprotkb": "Or1l4", "gene_names_refseq": "Olr428; Or1l4", "protein_names_uniprotkb": "Olfactory receptor family 1 subfamily L member 4", "protein_names_refseq": "olfactory receptor 428; olfactory receptor Olr428; olfactory receptor gene Olr428", "tax_id": 10116, "disease": "", "pathway": " (rno:296689)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZPB4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZPP7-1", "uniprot_id": [ { "id": "D3ZPP7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZPP7", "type": "external" } ], "mass": 40970.0, "length": 369, "protein_name": "Leucine-rich repeats and transmembrane domains 2", "gene_name": "Lrtm2", "organism": "Rat", "refseq_name": "leucine-rich repeat and transmembrane domain-containing protein 2", "refseq_ac": [ { "id": "NP_001102900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102900", "type": "external" } ], "gene_names_uniprotkb": "Lrtm2", "gene_names_refseq": "Lrtm2", "protein_names_uniprotkb": "Leucine-rich repeats and transmembrane domains 2", "protein_names_refseq": "leucine-rich repeat and transmembrane domain-containing protein 2; leucine-rich repeats and transmembrane domains 2", "tax_id": 10116, "disease": "", "pathway": " (rno:680883)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0051965 positive regulation of synapse assembly;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZPP7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZPR2-1", "uniprot_id": [ { "id": "D3ZPR2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZPR2", "type": "external" } ], "mass": 55789.0, "length": 516, "protein_name": "Zinc finger protein 395", "gene_name": "Zfp395", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zfp395", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 395", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:305972)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZPR2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZPS4-1", "uniprot_id": [ { "id": "D3ZPS4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZPS4", "type": "external" } ], "mass": 58180.0, "length": 549, "protein_name": "SPNS lysolipid transporter 2, sphingosine-1-phosphate", "gene_name": "Spns2", "organism": "Rat", "refseq_name": "sphingosine-1-phosphate transporter SPNS2", "refseq_ac": [ { "id": "NP_001376184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376184", "type": "external" } ], "gene_names_uniprotkb": "Spns2", "gene_names_refseq": "Spns2", "protein_names_uniprotkb": "SPNS lysolipid transporter 2, sphingosine-1-phosphate", "protein_names_refseq": "protein spinster homolog 2; 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ELOVL3", "gene_names_refseq": "Elovl3", "protein_names_uniprotkb": "Elongation of very long chain fatty acids protein 3; 2.3.1.199; 3-keto acyl-CoA synthase ELOVL3; ELOVL FA elongase 3; ELOVL fatty acid elongase 3; Very long chain 3-ketoacyl-CoA synthase 3; Very long chain 3-oxoacyl-CoA synthase 3", "protein_names_refseq": "elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3; elongation of very long chain fatty acids protein 3; elongation of very long chain fatty acids-like 3; very long chain fatty acid elongase 3", "tax_id": 10116, "disease": "", "pathway": " (rno:309449); (R-RNO-2046105); (R-RNO-2046106); (R-RNO-75876)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.199", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.199", "type": "external" } ], "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0034625 fatty acid elongation, monounsaturated fatty acid;GO:0034626 fatty acid elongation, polyunsaturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZPX9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZPZ3-1", "uniprot_id": [ { "id": "D3ZPZ3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZPZ3", "type": "external" } ], "mass": 58096.0, "length": 523, "protein_name": "DNA-(apurinic or apyrimidinic site) endonuclease", "gene_name": "Apex2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Apex2", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA-(apurinic or apyrimidinic site) endonuclease; 3.1.-.-", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0008081 phosphoric diester hydrolase activity;GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005743 mitochondrial inner membrane;GO:0001650 fibrillar center;GO:0005739 mitochondrion", "go_biological_process": "GO:0006310 DNA recombination;GO:0006284 base-excision repair;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZPZ3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQ04-1", "uniprot_id": [ { "id": "D3ZQ04_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQ04", "type": "external" } ], "mass": 97464.0, "length": 854, "protein_name": "Vomeronasal 2 receptor, 67", "gene_name": "Vom2r67", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Vom2r67", "gene_names_refseq": "", "protein_names_uniprotkb": "Vomeronasal 2 receptor, 67", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:689485)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZQ04-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQ06-1", "uniprot_id": [ { "id": "D3ZQ06_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQ06", "type": "external" } ], "mass": 39116.0, "length": 352, "protein_name": "Dead end protein homolog 1", "gene_name": "Dnd1", "organism": "Rat", "refseq_name": "dead end protein homolog 1", "refseq_ac": [ { "id": "NP_001102849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102849", "type": "external" } ], "gene_names_uniprotkb": "Dnd1", "gene_names_refseq": "Dnd1", "protein_names_uniprotkb": "Dead end protein homolog 1; RNA-binding motif, single-stranded-interacting protein 4", "protein_names_refseq": "dead end homolog 1; dead end protein homolog 1", "tax_id": 10116, "disease": "teratocarcinoma (Disease Ontology:DOID:3305)", "pathway": " (rno:679841)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21570390;22655094", "class_list": "", "function": "Dnd1 ter mutation causes germ cell loss, infertility and initiates gonadal teratomas., [RefSeq, PubMed]; The inactivation of the putative tumor suppressor gene Dnd1 facilitates the immortalization of late EGCs in vitro., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060965 negative regulation of miRNA-mediated gene silencing;GO:0007283 spermatogenesis;GO:0048255 mRNA stabilization;GO:0007281 germ cell development;GO:0061158 3'-UTR-mediated mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZQ06-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQ37-1", "uniprot_id": [ { "id": "D3ZQ37_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQ37", "type": "external" } ], "mass": 71369.0, "length": 627, "protein_name": "Kelch repeat and BTB domain containing 12", "gene_name": "Kbtbd12", "organism": "Rat", "refseq_name": "kelch repeat and BTB domain containing 12", "refseq_ac": [ { "id": "NP_001418799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001418799", "type": "external" } ], "gene_names_uniprotkb": "Kbtbd12", "gene_names_refseq": "Kbtbd12", "protein_names_uniprotkb": "Kelch repeat and BTB domain containing 12", "protein_names_refseq": "kelch repeat and BTB (POZ) domain containing 12; kelch repeat and BTB domain containing 12; kelch repeat and BTB domain-containing protein 12", "tax_id": 10116, "disease": "", "pathway": " (rno:502859)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZQ37-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQB5-1", "uniprot_id": [ { "id": "D3ZQB5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQB5", "type": "external" } ], "mass": 18191.0, "length": 167, "protein_name": "Claudin domain-containing protein 2", "gene_name": "Cldnd2", "organism": "Rat", "refseq_name": "claudin domain-containing protein 2", "refseq_ac": [ { "id": "NP_001102613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102613", "type": "external" } ], "gene_names_uniprotkb": "Cldnd2", "gene_names_refseq": "Cldnd2; RGD1566413", "protein_names_uniprotkb": "Claudin domain-containing protein 2", "protein_names_refseq": "claudin domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:499140)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZQB5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQC0-1", "uniprot_id": [ { "id": "D3ZQC0_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQC0", "type": "external" } ], "mass": 13284.0, "length": 137, "protein_name": "Late cornified envelope 1F", "gene_name": "LOC103695131", "organism": "Rat", "refseq_name": "late cornified envelope protein 1C-like", "refseq_ac": [ { "id": "XP_038959256", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038959256", "type": "external" } ], "gene_names_uniprotkb": "LOC103695131", "gene_names_refseq": "LOC103695131", "protein_names_uniprotkb": "Late cornified envelope 1F", "protein_names_refseq": "late cornified envelope protein 1C-like", "tax_id": 10116, "disease": "", "pathway": " (rno:103695131)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0031424 keratinization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZQC0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQH9-1", "uniprot_id": [ { "id": "D3ZQH9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQH9", "type": "external" } ], "mass": 97109.0, "length": 869, "protein_name": "RAS p21 protein activator 4", "gene_name": "Rasa4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rasa4", "gene_names_refseq": "", "protein_names_uniprotkb": "RAS p21 protein activator 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:288589); (R-RNO-5658442)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16641100", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0035556 intracellular signal transduction;GO:0071277 cellular response to calcium ion;GO:1902531 regulation of intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZQH9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQK4-1", "uniprot_id": [ { "id": "D3ZQK4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQK4", "type": "external" } ], "mass": 95493.0, "length": 853, "protein_name": "Thioredoxin domain containing 16", "gene_name": "Txndc16", "organism": "Rat", "refseq_name": "thioredoxin domain-containing protein 16 isoform X2", "refseq_ac": [ { "id": "XP_038949713", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038949713", "type": "external" } ], "gene_names_uniprotkb": "Txndc16", "gene_names_refseq": "RGD1306755; Txndc16", "protein_names_uniprotkb": "Thioredoxin domain containing 16", "protein_names_refseq": "thioredoxin domain-containing protein 16 isoform X2", "tax_id": 10116, "disease": "", "pathway": " (rno:361025)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZQK4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQL3-1", "uniprot_id": [ { "id": "D3ZQL3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQL3", "type": "external" } ], "mass": 70654.0, "length": 620, "protein_name": "Guanylate binding protein 4", "gene_name": "Gbp4", "organism": "Rat", "refseq_name": "guanylate-binding protein 4", "refseq_ac": [ { "id": "NP_001292190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292190", "type": "external" } ], "gene_names_uniprotkb": "Gbp4; LOC100911495", "gene_names_refseq": "Gbp4", "protein_names_uniprotkb": "Guanylate binding protein 4", "protein_names_refseq": "guanylate nucleotide binding protein 3; guanylate nucleotide binding protein 4; guanylate-binding protein 4-like; guanylate-binding protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:310917)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0044406 adhesion of symbiont to host;GO:0050830 defense response to Gram-positive bacterium;GO:0071222 cellular response to lipopolysaccharide;GO:0042742 defense response to bacterium;GO:0071346 cellular response to type II interferon", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZQL3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQL7-1", "uniprot_id": [ { "id": "TPPP_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQL7", "type": "external" } ], "mass": 23547.0, "length": 218, "protein_name": "Tubulin polymerization-promoting protein", "gene_name": "Tppp", "organism": "Rat", "refseq_name": "tubulin polymerization-promoting protein", "refseq_ac": [ { "id": "NP_001101931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101931", "type": "external" } ], "gene_names_uniprotkb": "Tppp", "gene_names_refseq": "RGD1310121; TPPP/p25; Tppp", "protein_names_uniprotkb": "Tubulin polymerization-promoting protein; 25 kDa brain-specific protein; 3.6.5.-; TPPP/p25; TPPP; p25-alpha", "protein_names_refseq": "25 kDa brain-specific protein; p25-alpha; tubulin polymerization-promoting protein", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:361466)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18563798;19606501;22673903;23629650;31522887;8417144", "class_list": "", "function": "Exophagy, with or without expression of TPPP, may be an important physiological mechanism for unconventional secretion of alpha-synuclein from dopaminergic neurons., [RefSeq, PubMed]; Malfunction of the proteasomal system, leading to the accumulation of aggregation prone proteins and the pro-aggregatory protein TPPP/p25alpha, is causally related to the protein aggregation process in a variety of neurodegenerative diseases., [RefSeq, PubMed]; Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:19606501). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (By similarity). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (By similarity). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (By similarity). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (By similarity). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (By similarity). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (By similarity). Plays a role in cell proliferation by regulating the G1/S-phase transition (By similarity). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (By similarity)., [UniProtKB, PubMed, UniProtKB]; These results demonstrate that TPPP on Golgi outposts are important for local microtubule nucleation and myelin sheath elongation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2K2D6", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0008017 microtubule binding;GO:0042803 protein homodimerization activity;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0051301 cell division;GO:0031334 positive regulation of protein-containing complex assembly;GO:0014003 oligodendrocyte development;GO:0032288 myelin assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D3ZQL7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQM9-1", "uniprot_id": [ { "id": "D3ZQM9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQM9", "type": "external" } ], "mass": 12722.0, "length": 112, "protein_name": "Ig-like domain-containing protein", "gene_name": "AABR07065789.1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AABR07065789.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig-like domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZQM9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQN6-1", "uniprot_id": [ { "id": "D3ZQN6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQN6", "type": "external" } ], "mass": 41086.0, "length": 361, "protein_name": "SH3 and cysteine-rich domain-containing protein 3", "gene_name": "Stac3", "organism": "Rat", "refseq_name": "SH3 and cysteine-rich domain-containing protein 3 isoform 1", "refseq_ac": [ { "id": "NP_001124030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124030", "type": "external" } ], "gene_names_uniprotkb": "Stac3", "gene_names_refseq": "Stac3", "protein_names_uniprotkb": "SH3 and cysteine-rich domain-containing protein 3", "protein_names_refseq": "SH3 and cysteine-rich domain-containing protein 3 isoform 1; SH3 and cysteine-rich domain-containing protein 3", "tax_id": 10116, "disease": "congenital myopathy 13 (Disease Ontology:DOID:0060346)", "pathway": " (rno:362895)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "33409656", "class_list": "", "function": "Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels. Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane. Slows down the inactivation rate of the calcium channel CACNA1C., [UniProtKB, UniProtKB, UniProtKB]; Testicular STAC3 regulates Leydig cell steroidogenesis through potentiating mitochondrial membrane potential and StAR processing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, 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"record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQN8-1", "uniprot_id": [ { "id": "D3ZQN8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQN8", "type": "external" } ], "mass": 74014.0, "length": 661, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "Nuak1", "organism": "Rat", "refseq_name": "NUAK family SNF1-like kinase 1", "refseq_ac": [ { "id": "NP_001100244", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100244", "type": "external" } ], "gene_names_uniprotkb": "Nuak1", "gene_names_refseq": "Nuak1; RGD1309956", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "AMPK-related protein kinase 5; NUAK family SNF1-like kinase 1; NUAK family, SNF1-like kinase, 1", "tax_id": 10116, "disease": "uterine fibroid (Disease Ontology:DOID:13223)", "pathway": " (rno:299694); (R-RNO-6804756)", 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"url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0002039 p53 binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0030155 regulation of cell adhesion;GO:2000772 regulation of cellular senescence", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZQN8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZR16-1", "uniprot_id": [ { "id": "D3ZR16_RAT", "url": "https://www.uniprot.org/uniprot/D3ZR16", "type": "external" } ], "mass": 15978.0, "length": 154, "protein_name": "Uncharacterized protein", "gene_name": "AC099183.3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AC099183.3", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZR16-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZR43-1", "uniprot_id": [ { "id": "D3ZR43_RAT", "url": "https://www.uniprot.org/uniprot/D3ZR43", "type": "external" } ], "mass": 57600.0, "length": 508, "protein_name": "Angiopoietin 4", "gene_name": "Angpt4", "organism": "Rat", "refseq_name": "angiopoietin-4 precursor", "refseq_ac": [ { "id": "NP_001099996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099996", "type": "external" } ], "gene_names_uniprotkb": "Angpt4", "gene_names_refseq": "Agpt4; 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3.4.24.7", "protein_names_refseq": "interstitial collagenase A-like; interstitial collagenase B precursor; interstitial collagenase B-like; interstitial collagenase B; matrix metalloproteinase 1b (interstitial collagenase)", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); renal fibrosis (Disease Ontology:DOID:0050855); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); thrombosis (Disease Ontology:DOID:0060903); COVID-19 (Disease Ontology:DOID:0080600); immunoglobulin light chain amyloidosis (Disease Ontology:DOID:0080933); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); carotid stenosis (Disease Ontology:DOID:13001); lung cancer (Disease Ontology:DOID:1324); thoracic aortic aneurysm (Disease Ontology:DOID:14004); breast cancer (Disease Ontology:DOID:1612); aortic valve stenosis (Disease Ontology:DOID:1712); atherosclerosis (Disease Ontology:DOID:1936); obstructive lung disease (Disease Ontology:DOID:2320); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); systemic scleroderma (Disease Ontology:DOID:418); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); esophagus adenocarcinoma (Disease Ontology:DOID:4914); epidermolysis bullosa dystrophica (Disease Ontology:DOID:4959); stomach carcinoma (Disease Ontology:DOID:5517); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); varicose veins (Disease Ontology:DOID:799); periodontitis (Disease Ontology:DOID:824); osteoarthritis (Disease Ontology:DOID:8398); localized scleroderma (Disease Ontology:DOID:8472); intermediate coronary syndrome (Disease Ontology:DOID:8805); skin melanoma (Disease Ontology:DOID:8923); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074); Barrett's esophagus (Disease Ontology:DOID:9206); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (R-RNO-1442490); (R-RNO-1474228); (R-RNO-1592389); (R-RNO-210991); (R-RNO-381426)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 49, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.24.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22", "type": "external" }, { "id": "3.4.21.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.21.39", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.39", "type": "external" }, { "id": "3.4.21.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.59", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZRZ2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZS52-1", "uniprot_id": [ { "id": "D3ZS52_RAT", "url": "https://www.uniprot.org/uniprot/D3ZS52", "type": "external" } ], "mass": 9065.0, "length": 79, "protein_name": "Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit TMEM258", "gene_name": "Tmem258b", "organism": "Rat", "refseq_name": "transmembrane protein 258 B", "refseq_ac": [ { "id": "NP_001395623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001395623", "type": "external" } ], "gene_names_uniprotkb": "Tmem258b", "gene_names_refseq": "Tmem258b; 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Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005770 late endosome", "go_biological_process": "GO:0002091 negative regulation of receptor internalization;GO:0048259 regulation of receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZUJ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUQ4-1", "uniprot_id": [ { "id": "D3ZUQ4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUQ4", "type": "external" } ], "mass": 34681.0, "length": 316, "protein_name": "Olfactory receptor", "gene_name": "Or52l1b; Or52l1", "organism": "Rat", "refseq_name": "olfactory receptor Olr196", "refseq_ac": [ { "id": "NP_001000187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000187", "type": "external" } ], "gene_names_uniprotkb": "Or52l1b; Or52l1; Or52l1", "gene_names_refseq": "Olr196; Or52l1; ratchr1-163062782-163061832_ORF", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 196; olfactory receptor Olr196; olfactory receptor gene Olr196", "tax_id": 10116, "disease": "", "pathway": " (rno:293338)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZUQ4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUQ7-1", "uniprot_id": [ { "id": "D3ZUQ7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUQ7", "type": "external" } ], "mass": 41090.0, "length": 370, "protein_name": "Pantothenate kinase 3", "gene_name": "Pank3", "organism": "Rat", "refseq_name": "pantothenate kinase 3", "refseq_ac": [ { "id": "NP_001101742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101742", "type": "external" } ], "gene_names_uniprotkb": "Pank3", "gene_names_refseq": "Pank3", "protein_names_uniprotkb": "Pantothenate kinase 3; 2.7.1.33; Pantothenic acid kinase 3", "protein_names_refseq": "pantothenate kinase 3", "tax_id": 10116, "disease": "pantothenate kinase-associated neurodegeneration (Disease Ontology:DOID:3981)", "pathway": " (rno:360511); (R-RNO-196783)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.33", "type": "external" } ], "go_molecular_function": "GO:0019842 vitamin binding;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0004594 pantothenate kinase activity;GO:1905502 acetyl-CoA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016310 phosphorylation;GO:0015937 coenzyme A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZUQ7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZV22-1", "uniprot_id": [ { "id": "D3ZV22_RAT", "url": "https://www.uniprot.org/uniprot/D3ZV22", "type": "external" } ], "mass": 44563.0, "length": 403, "protein_name": "S-adenosylmethionine sensor upstream of mTORC1", "gene_name": "Samtor", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Samtor; BMT2; Bmt2; LOC500034; SAMTOR", "gene_names_refseq": "", "protein_names_uniprotkb": "S-adenosylmethionine sensor upstream of mTORC1; 2.1.1.-; Probable methyltransferase BMT2 homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:500034); (R-RNO-9639288)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0008168 methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding", "go_cellular_component": "", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0032259 methylation;GO:0034198 cellular response to amino acid starvation;GO:1903432 regulation of TORC1 signaling;GO:0061431 cellular response to methionine", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZV22-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVB6-1", "uniprot_id": [ { "id": "D3ZVB6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVB6", "type": "external" } ], "mass": 17960.0, "length": 166, "protein_name": "Lipoprotein(a) like 2, pseudogene", "gene_name": "Lpal2", "organism": "Rat", "refseq_name": "uncharacterized protein LOC690326 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001103048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103048", "type": "external" } ], "gene_names_uniprotkb": "Lpal2; LOC690326", "gene_names_refseq": "Lpal2", "protein_names_uniprotkb": "Lipoprotein(a) like 2, pseudogene", "protein_names_refseq": "lipoprotein(a) like 2, pseudogene; uncharacterized protein LOC690326 isoform 1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:690326)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVB6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVH4-1", "uniprot_id": [ { "id": "D3ZVH4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVH4", "type": "external" } ], "mass": 34958.0, "length": 313, "protein_name": "Olfactory receptor family 10 subfamily G member 3", "gene_name": "Or10g3", "organism": "Rat", "refseq_name": "olfactory receptor Olr1640", "refseq_ac": [ { "id": "NP_001000099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000099", "type": "external" } ], "gene_names_uniprotkb": "Or10g3", "gene_names_refseq": "Olr1640; Or10g3", "protein_names_uniprotkb": "Olfactory receptor family 10 subfamily G member 3", "protein_names_refseq": "olfactory receptor 1640; olfactory receptor Olr1640; olfactory receptor gene Olr1640", "tax_id": 10116, "disease": "", "pathway": " (rno:290049)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVH4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVK0-1", "uniprot_id": [ { "id": "D3ZVK0_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVK0", "type": "external" } ], "mass": 58506.0, "length": 526, "protein_name": "Meiosis 1 associated protein", "gene_name": "M1ap", "organism": "Rat", "refseq_name": "meiosis 1 arrest protein", "refseq_ac": [ { "id": "XP_006236781", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006236781", "type": "external" } ], "gene_names_uniprotkb": "M1ap; RGD1563842", "gene_names_refseq": "M1ap", "protein_names_uniprotkb": "Meiosis 1 associated protein", "protein_names_refseq": "meiosis 1 arrest protein", "tax_id": 10116, "disease": "spermatogenic failure 48 (Disease Ontology:DOID:0112176)", "pathway": " (rno:500223)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007292 female gamete generation;GO:0007127 meiosis I;GO:0051308 male meiosis chromosome separation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVK0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVK3-1", "uniprot_id": [ { "id": "D3ZVK3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVK3", "type": "external" } ], "mass": 55279.0, "length": 495, "protein_name": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "gene_name": "Trmt6", "organism": "Rat", "refseq_name": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "refseq_ac": [ { "id": "NP_001101249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101249", "type": "external" } ], "gene_names_uniprotkb": "Trmt6", "gene_names_refseq": "RGD1308877; Trmt6", "protein_names_uniprotkb": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6", "protein_names_refseq": "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6; tRNA methyltransferase 6 homolog", "tax_id": 10116, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (rno:311441)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031515 tRNA (m1A) methyltransferase complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVK3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVL4-1", "uniprot_id": [ { "id": "D3ZVL4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVL4", "type": "external" } ], "mass": 35410.0, "length": 316, "protein_name": "Cilia-and flagella-associated protein 96", "gene_name": "Cfap96", "organism": "Rat", "refseq_name": "cilia and flagella associated protein 96", "refseq_ac": [ { "id": "NP_001420081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001420081", "type": "external" } ], "gene_names_uniprotkb": "Cfap96; C16h4orf47; RGD1564308", "gene_names_refseq": "C16h4orf47; Cfap96; RGD1564308", "protein_names_uniprotkb": "Cilia-and flagella-associated protein 96", "protein_names_refseq": "UPF0602 protein C4orf47 homolog; cilia and flagella associated protein 96", "tax_id": 10116, "disease": "", "pathway": " (rno:502086)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005881 cytoplasmic microtubule;GO:0097731 9+0 non-motile cilium", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVL4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVQ8-1", "uniprot_id": [ { "id": "D3ZVQ8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVQ8", "type": "external" } ], "mass": 25618.0, "length": 218, "protein_name": "Glutathione S-transferase", "gene_name": "Gstm3", "organism": "Rat", "refseq_name": "glutathione S-transferase Mu 3", "refseq_ac": [ { "id": "NP_065415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065415", "type": "external" } ], "gene_names_uniprotkb": "Gstm3", "gene_names_refseq": "GstYb4; Gstm3l1; Gstm3l; Gstm3; Gstm4", "protein_names_uniprotkb": "Glutathione S-transferase; 2.5.1.18", "protein_names_refseq": "glutathione S-transferase M3; glutathione S-transferase M4; glutathione S-transferase Mu 3; glutathione S-transferase Yb4; glutathione S-transferase mu 3-like 1", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:57298)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0071466 cellular response to xenobiotic stimulus;GO:0009617 response to bacterium;GO:0042178 xenobiotic catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVQ8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVT7-1", "uniprot_id": [ { "id": "D3ZVT7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVT7", "type": "external" } ], "mass": 106382.0, "length": 965, "protein_name": "Calcium-activated chloride channel regulator 2", "gene_name": "Clca2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Clca2", "gene_names_refseq": "", "protein_names_uniprotkb": "Calcium-activated chloride channel regulator 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:308016); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0015276 ligand-gated monoatomic ion channel activity;GO:0046872 metal ion binding;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0006508 proteolysis;GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVT7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVU2-1", "uniprot_id": [ { "id": "D3ZVU2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVU2", "type": "external" } ], "mass": 112754.0, "length": 1020, "protein_name": "Fanconi-associated nuclease", "gene_name": "Fan1", "organism": "Rat", "refseq_name": "fanconi-associated nuclease 1 isoform 1", "refseq_ac": [ { "id": "NP_001178562", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178562", "type": "external" } ], "gene_names_uniprotkb": "Fan1", "gene_names_refseq": "Fan1; Mtmr15; RGD1566323", "protein_names_uniprotkb": "Fanconi-associated nuclease; 3.1.4.1", "protein_names_refseq": "FANCD2/FANCI-associated nuclease 1; coiled-coil domain-containing protein MTMR15; fanconi-associated nuclease 1 isoform 1; fanconi-associated nuclease 1; myotubularin related protein 15", "tax_id": 10116, "disease": "karyomegalic interstitial nephritis (Disease Ontology:DOID:0060911); Fanconi anemia (Disease Ontology:DOID:13636)", "pathway": " (rno:309256); (R-RNO-6783310)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap. Also has endonuclease activity toward 5'-flaps., [UniProtKB, UniProtKB, UniProtKB]; Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0008270 zinc ion binding;GO:0004528 phosphodiesterase I activity;GO:0008409 5'-3' exonuclease activity;GO:0017108 5'-flap endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0000724 double-strand break repair via homologous recombination;GO:0036297 interstrand cross-link repair;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVU2-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVW8-1", "uniprot_id": [ { "id": "D3ZVW8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVW8", "type": "external" } ], "mass": 19512.0, "length": 174, "protein_name": "Membrane spanning 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which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, 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protein binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0031175 neuron projection development;GO:0050905 neuromuscular process;GO:0051402 neuron apoptotic process;GO:0043524 negative regulation of neuron apoptotic process;GO:0021522 spinal cord motor neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZX48-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZX56-1", "uniprot_id": [ { "id": "D3ZX56_RAT", "url": "https://www.uniprot.org/uniprot/D3ZX56", "type": "external" } ], "mass": 68576.0, "length": 600, "protein_name": "ATP-dependent RNA helicase", "gene_name": "Ddx55", "organism": "Rat", "refseq_name": "ATP-dependent RNA helicase DDX55", "refseq_ac": [ { "id": "NP_001258255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258255", "type": "external" } ], "gene_names_uniprotkb": "Ddx55", "gene_names_refseq": "Ddx55", "protein_names_uniprotkb": "ATP-dependent RNA helicase; 3.6.4.13", "protein_names_refseq": "ATP-dependent RNA helicase DDX55; DEAD (Asp-Glu-Ala-Asp) box polypeptide 55", "tax_id": 10116, "disease": "", "pathway": " (rno:100362764)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Probable ATP-binding RNA helicase. Has ATPase activity and is involved in the maturation of precursor large subunit rRNAs., [UniProtKB, UniProtKB, UniProtKB]; RNA helicase., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": 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"url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0070180 large ribosomal subunit rRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZX56-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZXB2-1", "uniprot_id": [ { "id": "D3ZXB2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZXB2", "type": "external" } ], "mass": 38164.0, "length": 324, "protein_name": "Sphingolipid delta(4)-desaturase DES1", "gene_name": "Degs1l2", "organism": "Rat", "refseq_name": "uncharacterized protein LOC289322", "refseq_ac": [ { "id": "NP_001417712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001417712", "type": "external" } ], "gene_names_uniprotkb": "Degs1l2; RGD1564463", "gene_names_refseq": "Degs1l2; RGD1564463", "protein_names_uniprotkb": "Sphingolipid delta(4)-desaturase DES1; 1.14.19.17; Degenerative spermatocyte homolog 1; Dihydroceramide desaturase-1; Retinol isomerase", "protein_names_refseq": "sphingolipid delta(4)-desaturase DES1; uncharacterized protein LOC289322", "tax_id": 10116, "disease": "hypomyelinating leukodystrophy (Disease Ontology:DOID:0060786); hypomyelinating leukodystrophy 18 (Disease Ontology:DOID:0070399); neurodegenerative disease (Disease Ontology:DOID:1289); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:289322)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Catalyzes the equilibrium isomerization of retinols., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "1.14.18.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.18.5", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0016853 isomerase activity;GO:0042284 sphingolipid delta-4 desaturase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZXB2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZXD0-1", "uniprot_id": [ { "id": "D3ZXD0_RAT", "url": "https://www.uniprot.org/uniprot/D3ZXD0", "type": "external" } ], "mass": 19348.0, "length": 168, "protein_name": "Gremlin", "gene_name": "Grem2", "organism": "Rat", "refseq_name": "gremlin-2 precursor", "refseq_ac": [ { "id": "NP_001099444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099444", "type": "external" } ], "gene_names_uniprotkb": "Grem2", "gene_names_refseq": "Grem2; RGD1560008", "protein_names_uniprotkb": "Gremlin", "protein_names_refseq": "gremlin 2 homolog, cysteine knot superfamily; gremlin-2 precursor; gremlin-2", "tax_id": 10116, "disease": "tooth agenesis (Disease Ontology:DOID:0050591)", "pathway": " (rno:289264); (R-RNO-201451)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "24614542;34049478", "class_list": "", "function": "LncRNA DNM3OS regulates GREM2 via miR-127-5p to suppress early chondrogenic differentiation of rat mesenchymal stem cells under hypoxic conditions. Publication Status: Online-Only, [RefSeq, PubMed]; Suggest that Grem2 is a part of the signaling network of growth factors that regulate the primordial to primary follicle transition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity;GO:0036122 BMP binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0010172 embryonic body morphogenesis;GO:0038098 sequestering of BMP from receptor via BMP binding;GO:0060300 regulation of cytokine activity;GO:0030514 negative regulation of BMP signaling pathway;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZXD0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZXN8-1", "uniprot_id": [ { "id": "D3ZXN8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZXN8", "type": "external" } ], "mass": 37244.0, "length": 324, "protein_name": "Annexin A10", "gene_name": "Anxa10", "organism": "Rat", "refseq_name": "annexin A10", "refseq_ac": [ { "id": "NP_001102580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102580", "type": "external" } ], "gene_names_uniprotkb": "Anxa10", "gene_names_refseq": "Anxa10; RGD1560956", "protein_names_uniprotkb": "Annexin A10", "protein_names_refseq": "annexin A10; palladin-like", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:498622)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "28866949;31208343", "class_list": "", "function": "Annexin A10 contributed to the development of neuropathic pain by activating spinal extracellular regulated kinase signalling and the subsequent release of tumour necrosis factor-alpha and interleukine-1beta in the spinal cord., [RefSeq, PubMed]; Spinal ANXA10/NF-kappaB/MMP-9 pathway, along with the activation of proinflammatory cytokines, was involved in the Spinal Nerve Ligation-induced Neuropathic Pain. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0012506 vesicle membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZXN8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZXW4-1", "uniprot_id": [ { "id": "D3ZXW4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZXW4", "type": "external" } ], "mass": 55663.0, "length": 504, "protein_name": "Glial cells missing transcription factor 2", "gene_name": "Gcm2", "organism": "Rat", "refseq_name": "chorion-specific transcription factor GCMb", "refseq_ac": [ { "id": "NP_001099575", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099575", "type": "external" } ], "gene_names_uniprotkb": "Gcm2", "gene_names_refseq": "Gcm2", "protein_names_uniprotkb": "Glial cells missing transcription factor 2", "protein_names_refseq": "chorion-specific transcription factor GCMb; glial cells missing homolog 2", "tax_id": 10116, "disease": "familial isolated hypoparathyroidism 2 (Disease Ontology:DOID:0061151); hypoparathyroidism (Disease Ontology:DOID:11199); hyperparathyroidism (Disease Ontology:DOID:13543); infertility (Disease Ontology:DOID:5223)", "pathway": " (rno:291047)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060017 parathyroid gland development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0043066 negative regulation of apoptotic process;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZXW4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZY42-1", "uniprot_id": [ { "id": "D3ZY42_RAT", "url": "https://www.uniprot.org/uniprot/D3ZY42", "type": "external" } ], "mass": 60774.0, "length": 499, "protein_name": "Trichoplein keratin filament-binding protein", "gene_name": "Tchp", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tchp", "gene_names_refseq": "", "protein_names_uniprotkb": "Trichoplein keratin filament-binding protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:304547)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0045179 apical cortex;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0006915 apoptotic process;GO:0030308 negative regulation of cell growth;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZY42-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZYK3-1", "uniprot_id": [ { "id": "D3ZYK3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZYK3", "type": "external" } ], "mass": 71610.0, "length": 650, "protein_name": "A-type voltage-gated potassium channel KCND1", "gene_name": "Kcnd1", "organism": "Rat", "refseq_name": "potassium voltage-gated channel subfamily D member 1 precursor", "refseq_ac": [ { "id": "NP_001099218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099218", "type": "external" } ], "gene_names_uniprotkb": "Kcnd1", "gene_names_refseq": "Kcnd1; Kv4.1", "protein_names_uniprotkb": "A-type voltage-gated potassium channel KCND1; Potassium voltage-gated channel subfamily D member 1; Voltage-gated potassium channel subunit Kv4.1", "protein_names_refseq": "potassium channel, voltage gated Shal-related subfamily D, member 1; potassium voltage gated channel Shal-related family member 1; potassium voltage-gated channel subfamily D member 1 precursor; potassium voltage-gated channel, Shal-related subfamily, member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:116695); (R-RNO-1296072); (R-RNO-5576894)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "36097791", "class_list": "", "function": "K(+) channel Kv4.1 is expressed in the nociceptors/secondary nociceptive neurons and participates in pain regulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005250 A-type (transient outward) potassium channel activity", "go_cellular_component": "GO:0043025 neuronal cell body;GO:0043197 dendritic spine;GO:0045211 postsynaptic membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZYK3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZYL0-1", "uniprot_id": [ { "id": "D3ZYL0_RAT", "url": "https://www.uniprot.org/uniprot/D3ZYL0", "type": "external" } ], "mass": 74756.0, "length": 658, "protein_name": "Receptor-interacting serine/threonine-protein kinase 1", "gene_name": "Ripk1", "organism": "Rat", "refseq_name": "receptor-interacting serine/threonine-protein kinase 1", "refseq_ac": [ { "id": "NP_001100820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100820", "type": "external" } ], "gene_names_uniprotkb": "Ripk1", "gene_names_refseq": "Ripk1", "protein_names_uniprotkb": "Receptor-interacting serine/threonine-protein kinase 1; 2.7.11.1; Cell death protein RIP; Receptor-interacting protein 1", "protein_names_refseq": "RIP; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor-interacting serine/threonine-protein kinase 1", "tax_id": 10116, "disease": "immunodeficiency 57 (Disease Ontology:DOID:0111952); squamous cell carcinoma (Disease Ontology:DOID:1749); epilepsy (Disease Ontology:DOID:1826); lichen planus (Disease Ontology:DOID:9201)", "pathway": " (rno:306886); (R-RNO-140534); (R-RNO-2562578); (R-RNO-3295583); (R-RNO-3371378); (R-RNO-5213460); (R-RNO-5218900); (R-RNO-5357786); (R-RNO-5357905); (R-RNO-5357956); (R-RNO-5675482); (R-RNO-5689880); (R-RNO-5689896); (R-RNO-69416); (R-RNO-75893); (R-RNO-937041)", "pathway_count": 16, "publication_count": 7, "publication_id_list": "22673903;29393594;34384567;35008931;35165268;37329446;39012929", "class_list": "", "function": "Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats., [RefSeq, PubMed]; RIPK1-RIPK3 mediates myocardial fibrosis in type 2 diabetes mellitus by impairing autophagic flux of cardiac fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]; Sirt1 Deficiency Promotes Age-Related AF Through Enhancing Atrial Necroptosis by Activation of RIPK1 Acetylation., [RefSeq, PubMed]; TAK1 Reduces Surgery-induced Overactivation of RIPK1 to Relieve Neuroinflammation and Cognitive Dysfunction in Aged Rats., [RefSeq, PubMed]; TNF-alpha-Mediated RIPK1 Pathway Participates in the Development of Trigeminal Neuropathic Pain in Rats. 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Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. 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sal-like protein 3 isoform 1; sal-like protein 3", "tax_id": 10116, "disease": "carcinoma (Disease Ontology:DOID:305)", "pathway": " (rno:364910)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable transcription factor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007224 smoothened signaling pathway;GO:0035136 forelimb morphogenesis;GO:0035137 hindlimb morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A024-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A060-1", "uniprot_id": [ { "id": "D4A060_RAT", "url": "https://www.uniprot.org/uniprot/D4A060", "type": "external" } ], "mass": 48637.0, "length": 431, "protein_name": "Sorting nexin-30", "gene_name": "Snx30", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Snx30", "gene_names_refseq": "", "protein_names_uniprotkb": "Sorting nexin-30", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0031901 early endosome membrane;GO:0005769 early endosome;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0015031 protein transport;GO:0000423 mitophagy;GO:0032456 endocytic recycling;GO:0034727 piecemeal microautophagy of the nucleus;GO:0061709 reticulophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A060-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A0E5-1", "uniprot_id": [ { "id": "D4A0E5_RAT", "url": "https://www.uniprot.org/uniprot/D4A0E5", "type": "external" } ], "mass": 56325.0, "length": 512, "protein_name": "Monocarboxylate transporter 14", "gene_name": "Slc16a14", "organism": "Rat", "refseq_name": "monocarboxylate transporter 14", "refseq_ac": [ { "id": "NP_001101699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101699", "type": "external" } ], "gene_names_uniprotkb": "Slc16a14", "gene_names_refseq": "Slc16a14", "protein_names_uniprotkb": "Monocarboxylate transporter 14; Solute carrier family 16 member 14", "protein_names_refseq": "monocarboxylate transporter 14; solute carrier family 16 (monocarboxylic acid transporters), member 14; solute carrier family 16, member 14 (monocarboxylic acid transporter 14)", "tax_id": 10116, "disease": "", "pathway": " (rno:316578)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2K058", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1905039 carboxylic acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A0E5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A0G9-1", "uniprot_id": [ { "id": "D4A0G9_RAT", "url": "https://www.uniprot.org/uniprot/D4A0G9", "type": "external" } ], "mass": 138174.0, "length": 1230, "protein_name": "DNA excision repair protein ERCC-6-like", "gene_name": "Ercc6l", "organism": "Rat", "refseq_name": "DNA excision repair protein ERCC-6-like", "refseq_ac": [ { "id": "NP_001092144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092144", "type": "external" } ], "gene_names_uniprotkb": "Ercc6l", "gene_names_refseq": "Ercc6l; RGD1565734", "protein_names_uniprotkb": "DNA excision repair protein ERCC-6-like; 3.6.4.12; ATP-dependent helicase ERCC6-like", "protein_names_refseq": "DNA excision repair protein ERCC-6-like; excision repair cross-complementation group 6-like; excision repair cross-complementing rodent repair deficiency complementation group 6 - like; excision repair cross-complementing rodent repair deficiency complementation group 6-like", "tax_id": 10116, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:317252); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "15917148;22673903", "class_list": "", "function": "Characterization of the mouse Ercc6l ortholog., [RefSeq, PubMed]; DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, 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"biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0007144 female meiosis I;GO:0007283 spermatogenesis;GO:0048255 mRNA stabilization;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A1P7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A1Q9-1", "uniprot_id": [ { "id": "D4A1Q9_RAT", "url": "https://www.uniprot.org/uniprot/D4A1Q9", "type": "external" } ], "mass": 79418.0, "length": 688, "protein_name": "Tubulin tyrosine ligase like 12", "gene_name": "Ttll12", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ttll12", "gene_names_refseq": "", "protein_names_uniprotkb": "Tubulin tyrosine ligase like 12", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-8955332)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016881 acid-amino acid ligase activity;GO:0140096 catalytic activity, acting on a protein;GO:0140005 histone H4K20me2 reader activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007346 regulation of mitotic cell cycle;GO:0060339 negative regulation of type I interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A1Q9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A1Z1-1", "uniprot_id": [ { "id": "D4A1Z1_RAT", "url": "https://www.uniprot.org/uniprot/D4A1Z1", "type": "external" } ], "mass": 67776.0, "length": 598, "protein_name": "Kelch-like family member 6", "gene_name": "Klhl6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Klhl6", "gene_names_refseq": "", "protein_names_uniprotkb": "Kelch-like family member 6", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:287974)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0009617 response to bacterium;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050853 B cell receptor signaling pathway;GO:0002467 germinal center formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A1Z1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A213-1", "uniprot_id": [ { "id": "D4A213_RAT", "url": "https://www.uniprot.org/uniprot/D4A213", "type": "external" } ], "mass": 53864.0, "length": 493, "protein_name": "Scavenger receptor class A member 5", "gene_name": "Scara5", "organism": "Rat", "refseq_name": "scavenger receptor class A member 5 isoform 1", "refseq_ac": [ { "id": "NP_001418361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001418361", "type": "external" } ], "gene_names_uniprotkb": "Scara5; SCARA5", "gene_names_refseq": "RGD1306539; Scara5", "protein_names_uniprotkb": "Scavenger receptor class A member 5", "protein_names_refseq": "scavenger receptor class A member 5 isoform 1; scavenger receptor class A, member 5 (putative)", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1)., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Z926", "ec_number_list": [], "go_molecular_function": "GO:0070287 ferritin receptor activity;GO:0005044 scavenger receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0034755 iron ion transmembrane transport;GO:0006897 endocytosis;GO:0006879 intracellular iron ion homeostasis;GO:0034605 cellular response to heat;GO:0070207 protein homotrimerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A213-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A243-1", "uniprot_id": [ { "id": "D4A243_RAT", "url": "https://www.uniprot.org/uniprot/D4A243", "type": "external" } ], "mass": 53541.0, "length": 478, "protein_name": "Enkurin domain containing 1", "gene_name": "Enkd1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Enkd1; RGD1307357", "gene_names_refseq": "", "protein_names_uniprotkb": "Enkurin domain containing 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:291975)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton;GO:0005814 centriole;GO:0005930 axoneme", "go_biological_process": "GO:0044458 motile cilium assembly;GO:1905515 non-motile cilium assembly;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A243-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A2A9-1", "uniprot_id": [ { "id": "D4A2A9_RAT", "url": "https://www.uniprot.org/uniprot/D4A2A9", "type": "external" } ], "mass": 117947.0, "length": 1024, "protein_name": "Gamma-tubulin complex component", "gene_name": "Tubgcp5", "organism": "Rat", "refseq_name": "gamma-tubulin complex component 5", "refseq_ac": [ { "id": "NP_001100986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100986", "type": "external" } ], "gene_names_uniprotkb": "Tubgcp5", "gene_names_refseq": "Tubgcp5", "protein_names_uniprotkb": "Gamma-tubulin complex component", "protein_names_refseq": "gamma-tubulin complex component 5; 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity. 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Overexpression causes down-regulation of a number of genes involved in the immune response. 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[provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A3F2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3H5-1", "uniprot_id": [ { "id": "D4A3H5_RAT", "url": "https://www.uniprot.org/uniprot/D4A3H5", "type": "external" } ], "mass": 95203.0, "length": 853, "protein_name": "Chloride channel protein", "gene_name": "Clcn6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Clcn6", "gene_names_refseq": "", "protein_names_uniprotkb": "Chloride channel protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "neuronal ceroid lipofuscinosis 15 (Disease Ontology:DOID:0061189); neuronal ceroid lipofuscinosis 3 (Disease Ontology:DOID:0110731); coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (R-RNO-2672351)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;38843836", "class_list": "", "function": "Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0015297 antiporter activity;GO:0005247 voltage-gated chloride channel activity", "go_cellular_component": "GO:0031902 late endosome membrane", "go_biological_process": "GO:0009612 response to mechanical stimulus;GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D4A3H5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3J3-1", "uniprot_id": [ { "id": "D4A3J3_RAT", "url": "https://www.uniprot.org/uniprot/D4A3J3", "type": "external" } ], "mass": 112820.0, "length": 989, "protein_name": "Centrosomal protein of 120 kDa", "gene_name": "Cep120", "organism": "Rat", "refseq_name": "centrosomal protein of 120 kDa isoform 1", "refseq_ac": [ { "id": "NP_001178626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178626", "type": "external" } ], "gene_names_uniprotkb": "Cep120", "gene_names_refseq": "Ccdc100; Cep120; RGD1565619", "protein_names_uniprotkb": "Centrosomal protein of 120 kDa; Coiled-coil domain-containing protein 100", "protein_names_refseq": "centrosomal protein 120kDa; centrosomal protein of 120 kDa isoform 1; centrosomal protein of 120 kDa; coiled-coil domain containing 100", "tax_id": 10116, "disease": "Joubert syndrome 31 (Disease Ontology:DOID:0080277); short-rib thoracic dysplasia 13 with or without polydactyly (Disease Ontology:DOID:0110093)", "pathway": " (rno:307302)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005814 centriole", "go_biological_process": "GO:1904951 positive regulation of establishment of protein localization;GO:0008283 cell population proliferation;GO:0021987 cerebral cortex development;GO:0032880 regulation of protein localization;GO:0032886 regulation of microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A3J3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3Q6-1", "uniprot_id": [ { "id": "D4A3Q6_RAT", "url": "https://www.uniprot.org/uniprot/D4A3Q6", "type": "external" } ], "mass": 18464.0, "length": 160, "protein_name": "Testis expressed 46", "gene_name": "Tex46", "organism": "Rat", "refseq_name": "testis-expressed protein 46", "refseq_ac": [ { "id": "NP_001386301", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386301", "type": "external" } ], "gene_names_uniprotkb": "Tex46; LOC102552669; RGD1311870", "gene_names_refseq": "RGD1311870; Tex46", "protein_names_uniprotkb": "Testis expressed 46", "protein_names_refseq": "testis-expressed protein 46; uncharacterized protein C1orf234 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:102552669)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A6B9RWJ8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A3Q6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3W6-1", "uniprot_id": [ { "id": "D4A3W6_RAT", "url": "https://www.uniprot.org/uniprot/D4A3W6", "type": "external" } ], "mass": 72822.0, "length": 661, "protein_name": "Dual specificity phosphatase 16", "gene_name": "Dusp16", "organism": "Rat", "refseq_name": "dual specificity protein phosphatase 16", "refseq_ac": [ { "id": "NP_001100094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100094", "type": "external" } ], "gene_names_uniprotkb": "Dusp16", "gene_names_refseq": "Dusp16; 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"https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0000287 magnesium ion binding;GO:0003677 DNA binding", 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"NP_001102040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102040", "type": "external" } ], "gene_names_uniprotkb": "Il36b", "gene_names_refseq": "Il1f8; Il36b", "protein_names_uniprotkb": "Interleukin-1", "protein_names_refseq": "interleukin 1 family, member 8; interleukin-36 beta", "tax_id": 10116, "disease": "", "pathway": " (rno:362076)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, 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"synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A6F3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A6J4-1", "uniprot_id": [ { "id": "D4A6J4_RAT", "url": "https://www.uniprot.org/uniprot/D4A6J4", "type": "external" } ], "mass": 112408.0, "length": 1003, "protein_name": "DNA topoisomerase", "gene_name": "Top3a", "organism": "Rat", "refseq_name": "DNA topoisomerase 3-alpha", "refseq_ac": [ { "id": "NP_001414385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414385", "type": "external" } ], "gene_names_uniprotkb": "Top3a", "gene_names_refseq": "Top3a", "protein_names_uniprotkb": "DNA topoisomerase; 5.6.2.1", "protein_names_refseq": "DNA topoisomerase 3-alpha; topoisomerase (DNA) III alpha", "tax_id": 10116, "disease": "autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5 (Disease Ontology:DOID:0111524)", 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Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003697 single-stranded DNA binding;GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0016605 PML body;GO:0031422 RecQ family helicase-topoisomerase III complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0000724 double-strand break repair via homologous recombination;GO:0006265 DNA topological change;GO:0051304 chromosome separation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A6J4-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A6K4-1", "uniprot_id": [ { "id": "D4A6K4_RAT", "url": "https://www.uniprot.org/uniprot/D4A6K4", "type": "external" } ], "mass": 87385.0, "length": 758, "protein_name": "Golgin subfamily A member 1", "gene_name": "Golga1", "organism": "Rat", "refseq_name": "golgin subfamily A member 1", "refseq_ac": [ { "id": "NP_001381951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001381951", "type": "external" } ], "gene_names_uniprotkb": "Golga1", "gene_names_refseq": "Golga1", "protein_names_uniprotkb": "Golgin subfamily A member 1; Golgin-97", "protein_names_refseq": "golgi autoantigen, golgin subfamily a, 1; golgin subfamily A member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:311919); (R-RNO-6811440)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. Mechanistically, captures transport vesicles arriving from endosomes via the protein TBC1D23. Recognized vesicles are then tethered to the trans-Golgi before subsequent SNARE engagement and vesicle fusion. Selectively regulates E-cadherin transport from the trans-Golgi network in tubulovesicular carriers., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0001669 acrosomal vesicle;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0070633 transepithelial transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A6K4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A6V4-1", "uniprot_id": [ { "id": "D4A6V4_RAT", "url": "https://www.uniprot.org/uniprot/D4A6V4", "type": "external" } ], "mass": 54748.0, "length": 470, "protein_name": "PRAME like 36", "gene_name": "Pramel36", "organism": "Rat", "refseq_name": "PRAME family member 8-like isoform X1", "refseq_ac": [ { "id": "XP_003751380", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003751380", "type": "external" } ], "gene_names_uniprotkb": "Pramel36; RGD1565660", "gene_names_refseq": "Pramel36", "protein_names_uniprotkb": "PRAME like 36", "protein_names_refseq": "PRAME family member 8-like isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:501896)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045596 negative regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A6V4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A6W6-1", "uniprot_id": [ { "id": "D4A6W6_RAT", "url": "https://www.uniprot.org/uniprot/D4A6W6", "type": "external" } ], "mass": 28157.0, "length": 257, "protein_name": "Large ribosomal subunit protein uL2", "gene_name": "Rpl8l1", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL2-like", "refseq_ac": [ { "id": "XP_038957368", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038957368", "type": "external" } ], "gene_names_uniprotkb": "Rpl8l1; AC129049.1; RGD1561333", "gene_names_refseq": "Rpl8l1", "protein_names_uniprotkb": "Large ribosomal subunit protein uL2; 60S ribosomal protein L8", "protein_names_refseq": "large ribosomal subunit protein uL2-like", "tax_id": 10116, "disease": "Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (rno:499374)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A6W6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A6X3-1", "uniprot_id": [ { "id": "D4A6X3_RAT", "url": "https://www.uniprot.org/uniprot/D4A6X3", "type": "external" } ], "mass": 110709.0, "length": 1020, "protein_name": "KN motif and ankyrin repeat domain-containing protein 4", "gene_name": "Kank4", "organism": "Rat", "refseq_name": "KN motif and ankyrin repeat domain-containing protein 4 isoform X1", "refseq_ac": [ { "id": "XP_008762090", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008762090", "type": "external" } ], "gene_names_uniprotkb": "Kank4", "gene_names_refseq": "BC060737; Kank4", "protein_names_uniprotkb": "KN motif and ankyrin repeat domain-containing protein 4; Ankyrin repeat domain-containing protein 38", "protein_names_refseq": "KN motif and ankyrin repeat domain-containing protein 4 isoform X1", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May be involved in the control of cytoskeleton formation by regulating actin polymerization., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0030837 negative regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A6X3-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A6X7-1", "uniprot_id": [ { "id": "D4A6X7_RAT", "url": "https://www.uniprot.org/uniprot/D4A6X7", "type": "external" } ], "mass": 33908.0, "length": 311, "protein_name": "Phosphopantothenate--cysteine ligase", "gene_name": "Ppcs", "organism": "Rat", "refseq_name": "phosphopantothenate--cysteine ligase", "refseq_ac": [ { "id": "NP_001034099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034099", "type": "external" } ], "gene_names_uniprotkb": "Ppcs", "gene_names_refseq": "Ppcs; 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Has a preference for ATP over CTP as a cosubstrate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.2.51", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.51", "type": "external" } ], "go_molecular_function": "GO:0004632 phosphopantothenate--cysteine ligase activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006085 acetyl-CoA biosynthetic process;GO:0015937 coenzyme A biosynthetic process;GO:0003015 heart process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A6X7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A700-1", "uniprot_id": [ { "id": "D4A700_RAT", "url": "https://www.uniprot.org/uniprot/D4A700", "type": "external" } ], "mass": 79204.0, "length": 712, "protein_name": "HHIP like 2", "gene_name": "Hhipl2", "organism": "Rat", "refseq_name": "HHIP-like protein 2 precursor", "refseq_ac": [ { "id": "NP_001416534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001416534", "type": "external" } ], "gene_names_uniprotkb": "Hhipl2", "gene_names_refseq": "Hhipl2; 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autosomal recessive nonsyndromic deafness 4 (Disease Ontology:DOID:0110498)", "pathway": " (rno:287185)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0042472 inner ear morphogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A7G2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A7G5-1", "uniprot_id": [ { "id": "D4A7G5_RAT", "url": "https://www.uniprot.org/uniprot/D4A7G5", "type": "external" } ], "mass": 103560.0, "length": 913, "protein_name": "Glucosidase, alpha; 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A8Z1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A914-1", "uniprot_id": [ { "id": "D4A914_RAT", "url": "https://www.uniprot.org/uniprot/D4A914", "type": "external" } ], "mass": 108646.0, "length": 951, "protein_name": "5'-3' exoribonuclease", "gene_name": "Xrn2", "organism": "Rat", "refseq_name": "5'-3' exoribonuclease 2", "refseq_ac": [ { "id": "NP_001102066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102066", "type": "external" } ], "gene_names_uniprotkb": "Xrn2", "gene_names_refseq": "Xrn2", "protein_names_uniprotkb": "5'-3' exoribonuclease; 3.1.13.-", "protein_names_refseq": "5'-3' exoribonuclease 2", "tax_id": 10116, "disease": "adenoid cystic carcinoma (Disease Ontology:DOID:0080202); lung cancer (Disease Ontology:DOID:1324); status epilepticus (Disease Ontology:DOID:1824); leiomyosarcoma (Disease Ontology:DOID:1967)", "pathway": " (rno:362229); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22673903;23700402;29393594", "class_list": "", "function": "Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; XRN2 and PAPD4 and are highly expressed in the retina and have distinct gene expression profiles during development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0001147 transcription termination site sequence-specific DNA binding;GO:0004534 5'-3' RNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006397 mRNA processing;GO:0007283 spermatogenesis;GO:0021766 hippocampus development;GO:0060041 retina development in camera-type eye;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D4A914-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A934-1", "uniprot_id": [ { "id": "D4A934_RAT", "url": "https://www.uniprot.org/uniprot/D4A934", "type": "external" } ], "mass": 74446.0, "length": 700, "protein_name": "Kin of IRRE-like protein 2", "gene_name": "Kirrel2", "organism": "Rat", "refseq_name": "kin of IRRE-like protein 2 precursor", "refseq_ac": [ { "id": "NP_001258327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258327", "type": "external" } ], "gene_names_uniprotkb": "Kirrel2", "gene_names_refseq": "Kirrel2", "protein_names_uniprotkb": "Kin of IRRE-like protein 2; Kin of irregular chiasm-like protein 2", "protein_names_refseq": "kin of IRRE like 2; kin of IRRE-like protein 2 precursor; kin of IRRE-like protein 2", "tax_id": 10116, "disease": "nephrotic syndrome (Disease Ontology:DOID:1184); kidney disease (Disease Ontology:DOID:557)", "pathway": " (rno:100359836); (R-RNO-373753)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May regulate basal insulin secretion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0034451 centriolar satellite;GO:0036057 slit diaphragm", "go_biological_process": "GO:0001933 negative regulation of protein phosphorylation;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A934-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A944-1", "uniprot_id": [ { "id": "D4A944_RAT", "url": "https://www.uniprot.org/uniprot/D4A944", "type": "external" } ], "mass": 43794.0, "length": 400, "protein_name": "U5 small nuclear ribonucleoprotein 40 kDa protein", "gene_name": "Snrnp40", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Snrnp40", "gene_names_refseq": "", "protein_names_uniprotkb": "U5 small nuclear ribonucleoprotein 40 kDa protein; WD repeat-containing protein 57", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-72163); (R-RNO-72165)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome;GO:0071014 post-mRNA release spliceosomal complex", "go_biological_process": "GO:0000375 RNA splicing, via transesterification reactions;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A944-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A972-1", "uniprot_id": [ { "id": "D4A972_RAT", "url": "https://www.uniprot.org/uniprot/D4A972", "type": "external" } ], "mass": 42296.0, "length": 366, "protein_name": "MAGE family member B5", "gene_name": "Mageb5", "organism": "Rat", "refseq_name": "melanoma-associated antigen B5", "refseq_ac": [ { "id": "NP_001100416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100416", "type": "external" } ], "gene_names_uniprotkb": "Mageb5; Mageb17", "gene_names_refseq": "Mageb17; Mageb5; RGD1563078", "protein_names_uniprotkb": "MAGE family member B5", "protein_names_refseq": "melanoma antigen family B, 17; melanoma antigen family B, 5; melanoma-associated antigen B5", "tax_id": 10116, "disease": "", "pathway": " (rno:302442)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A972-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A9D7-1", "uniprot_id": [ { "id": "D4A9D7_RAT", "url": "https://www.uniprot.org/uniprot/D4A9D7", "type": "external" } ], "mass": 39939.0, "length": 359, "protein_name": "Protein Wnt", "gene_name": "Wnt8a", "organism": "Rat", "refseq_name": "protein Wnt-8a precursor", "refseq_ac": [ { "id": "NP_001099625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099625", "type": "external" } ], "gene_names_uniprotkb": "Wnt8a", "gene_names_refseq": "Wnt8a", "protein_names_uniprotkb": "Protein Wnt", "protein_names_refseq": "protein Wnt-8a precursor; wingless-related MMTV integration site 8A; wingless-type MMTV integration site family, member 8A", "tax_id": 10116, "disease": "", "pathway": " (rno:291678); (R-RNO-3238698); (R-RNO-4641262)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0048561 establishment of animal organ orientation;GO:0009949 polarity specification of anterior/posterior axis;GO:0000902 cell morphogenesis;GO:0032880 regulation of protein localization;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A9D7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A9D8-1", "uniprot_id": [ { "id": "D4A9D8_RAT", "url": "https://www.uniprot.org/uniprot/D4A9D8", "type": "external" } ], "mass": 89043.0, "length": 805, "protein_name": "Oxysterol-binding protein", "gene_name": "Osbp", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Osbp", "gene_names_refseq": "", "protein_names_uniprotkb": "Oxysterol-binding protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-RNO-192105)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16641100;22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, 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"go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0006869 lipid transport;GO:0035627 ceramide transport;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0015914 phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A9D8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A9H7-1", "uniprot_id": [ { "id": "D4A9H7_RAT", "url": "https://www.uniprot.org/uniprot/D4A9H7", "type": "external" } ], "mass": 46674.0, "length": 426, "protein_name": "Spermatogenesis associated 2-like", "gene_name": "Spata2L", "organism": "Rat", "refseq_name": "spermatogenesis-associated protein 2-like protein", "refseq_ac": [ { "id": 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"ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A9H9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A9N8-1", "uniprot_id": [ { "id": "D4A9N8_RAT", "url": "https://www.uniprot.org/uniprot/D4A9N8", "type": "external" } ], "mass": 22504.0, "length": 200, "protein_name": "MPV17 mitochondrial inner membrane protein like 2", "gene_name": "Mpv17l2", "organism": "Rat", "refseq_name": "mpv17-like protein 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001099542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099542", "type": "external" } ], "gene_names_uniprotkb": "Mpv17l2", "gene_names_refseq": "Mpv17l2; RGD1308064", "protein_names_uniprotkb": "MPV17 mitochondrial inner membrane protein like 2", 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0.1, "record_id": "D4A9N8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A9X5-1", "uniprot_id": [ { "id": "D4A9X5_RAT", "url": "https://www.uniprot.org/uniprot/D4A9X5", "type": "external" } ], "mass": 38435.0, "length": 339, "protein_name": "Transmembrane protein 191C", "gene_name": "Tmem191c", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tmem191c; LOC100364951", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane protein 191C", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 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Publication Status: Online-Only, [RefSeq, PubMed]; Our findings in Ubqln2 transgenic and knockout rats collectively suggest that pathogenic Ubqln2 causes neuron death mainly through a gain of unrevealed functions rather than a loss of physiological functions, [RefSeq, PubMed]; The results of this study suggested that selectively expressing mutant UBQLN2(P497H) in motor neurons is sufficient to trigger the development of ALS in rats Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0016241 regulation of macroautophagy;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:1904294 positive regulation of ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "D4AA63-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AA72-1", "uniprot_id": [ { "id": "D4AA72_RAT", "url": "https://www.uniprot.org/uniprot/D4AA72", "type": "external" } ], "mass": 63569.0, "length": 568, "protein_name": "Protein phosphatase 1 regulatory inhibitor subunit 16B", "gene_name": "Ppp1r16b", "organism": "Rat", "refseq_name": "protein phosphatase 1 regulatory inhibitor subunit 16B", "refseq_ac": [ { "id": "NP_001178001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178001", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r16b", "gene_names_refseq": "Ppp1r16b", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory inhibitor subunit 16B; CAAX box protein TIMAP; TGF-beta-inhibited membrane-associated protein", "protein_names_refseq": "protein phosphatase 1 regulatory inhibitor subunit 16B; protein phosphatase 1, regulatory (inhibitor) subunit 16B", "tax_id": 10116, "disease": "", "pathway": " (rno:680616)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017020 myosin phosphatase regulator activity;GO:0004857 enzyme inhibitor activity;GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0061028 establishment of endothelial barrier;GO:0001938 positive regulation of endothelial cell proliferation;GO:1903670 regulation of sprouting angiogenesis;GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AA72-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AAB5-1", "uniprot_id": [ { "id": "D4AAB5_RAT", "url": "https://www.uniprot.org/uniprot/D4AAB5", "type": "external" } ], "mass": 46684.0, "length": 431, "protein_name": "Xaa-Arg dipeptidase", "gene_name": "Pm20d2", "organism": "Rat", "refseq_name": "xaa-Arg dipeptidase", "refseq_ac": [ { "id": "NP_001101392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101392", "type": "external" } ], "gene_names_uniprotkb": "Pm20d2", "gene_names_refseq": "Acy1l2; 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Postulated to function in a metabolite repair mechanism by eliminating alternate dipeptide by-products formed during carnosine synthesis., [UniProtKB, UniProtKB]; PM20D2 hydrolyzed beta-alanyl-lysine, beta-alanyl-ornithine, gamma-aminobutyryl-lysine, and gamma-aminobutyryl-ornithine as its best substrates., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004180 carboxypeptidase activity;GO:0016805 dipeptidase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0051246 regulation of protein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4AAB5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AAE1-1", "uniprot_id": [ { "id": "D4AAE1_RAT", "url": "https://www.uniprot.org/uniprot/D4AAE1", "type": "external" } ], "mass": 35384.0, "length": 309, "protein_name": "Olfactory receptor", "gene_name": "Or5k8", "organism": "Rat", "refseq_name": "olfactory receptor Olr1561", "refseq_ac": [ { "id": "NP_001000048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000048", "type": "external" } ], "gene_names_uniprotkb": "Or5k8", "gene_names_refseq": "Olr1561; Or5k8", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1561; olfactory receptor 181-like; olfactory receptor Olr1561; olfactory receptor gene Olr1561", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:288186)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AAE1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AAI8-1", "uniprot_id": [ { "id": "D4AAI8_RAT", "url": "https://www.uniprot.org/uniprot/D4AAI8", "type": "external" } ], "mass": 87208.0, "length": 785, "protein_name": "Adhesion G-protein coupled receptor G7", "gene_name": "Adgrg7", "organism": "Rat", "refseq_name": "adhesion G-protein coupled receptor G7", "refseq_ac": [ { "id": "NP_001100568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100568", "type": "external" } ], "gene_names_uniprotkb": "Adgrg7; LOC100911145", "gene_names_refseq": "Adgrg7; Gpr128", "protein_names_uniprotkb": "Adhesion G-protein coupled receptor G7; G-protein coupled receptor 128", "protein_names_refseq": "G protein-coupled receptor 128; adhesion G-protein coupled receptor G7; probable G-protein coupled receptor 128-like; probable G-protein coupled receptor 128", "tax_id": 10116, "disease": "", "pathway": " (rno:304014)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Orphan receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AAI8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AAJ3-1", "uniprot_id": [ { "id": "D4AAJ3_RAT", "url": "https://www.uniprot.org/uniprot/D4AAJ3", "type": "external" } ], "mass": 14412.0, "length": 132, "protein_name": "40S ribosomal protein S12", "gene_name": "Rps12l5", "organism": "Rat", "refseq_name": "similar to ribosomal protein S12", "refseq_ac": [ { "id": "NP_001389000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001389000", "type": "external" } ], "gene_names_uniprotkb": "Rps12l5; RGD1562265", "gene_names_refseq": "RGD1562265; Rps12l5", "protein_names_uniprotkb": "40S ribosomal protein S12", "protein_names_refseq": "40S ribosomal protein S12-like; similar to ribosomal protein S12", "tax_id": 10116, "disease": "", "pathway": " (rno:313283)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Subunit of the 40S ribosomal complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:1990145 maintenance of translational fidelity;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AAJ3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AAL8-1", "uniprot_id": [ { "id": "D4AAL8_RAT", "url": "https://www.uniprot.org/uniprot/D4AAL8", "type": "external" } ], "mass": 35547.0, "length": 314, "protein_name": "Olfactory receptor", "gene_name": "Or6c35f", "organism": "Rat", "refseq_name": "olfactory receptor Olr886", "refseq_ac": [ { "id": "NP_001001382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001382", "type": "external" } ], "gene_names_uniprotkb": "Or6c35f; Olr1049", "gene_names_refseq": "Olr886; Or6c35f", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 886; olfactory receptor Olr886; olfactory receptor gene Olr886", "tax_id": 10116, "disease": "", "pathway": " (rno:302254)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AAL8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AAS1-1", "uniprot_id": [ { "id": "D4AAS1_RAT", "url": "https://www.uniprot.org/uniprot/D4AAS1", "type": "external" } ], "mass": 65266.0, "length": 600, "protein_name": "G protein-coupled receptor 162", "gene_name": "Gpr162", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gpr162; 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Ypel", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein yippee-like", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:360590)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AAS2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AAT4-1", "uniprot_id": [ { "id": "D4AAT4_RAT", "url": "https://www.uniprot.org/uniprot/D4AAT4", "type": "external" } ], "mass": 9725.0, "length": 86, "protein_name": "Small nuclear ribonucleoprotein F", "gene_name": "Snrpf", "organism": "Rat", "refseq_name": "small nuclear ribonucleoprotein F", "refseq_ac": [ { "id": "NP_001119563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119563", "type": "external" } ], "gene_names_uniprotkb": "Snrpf", "gene_names_refseq": "Snrpf", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein F; 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Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. 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AABR07034639.1; RGD1559972", "gene_names_refseq": "Rpl27al7", "protein_names_uniprotkb": "Large ribosomal subunit protein uL15; 60S ribosomal protein L27a", "protein_names_refseq": "large ribosomal subunit protein uL15-like", "tax_id": 10116, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AAY6-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AB47-1", "uniprot_id": [ { "id": "D4AB47_RAT", "url": "https://www.uniprot.org/uniprot/D4AB47", "type": "external" } ], "mass": 28203.0, "length": 259, "protein_name": "Shisa like 2B", "gene_name": "Shisal2b", "organism": "Rat", "refseq_name": "protein shisa-like-2B", "refseq_ac": [ { "id": "XP_574844", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_574844", "type": "external" } ], "gene_names_uniprotkb": "Shisal2b", "gene_names_refseq": "Shisal2b", "protein_names_uniprotkb": "Shisa like 2B", "protein_names_refseq": "protein shisa-like-2B", "tax_id": 10116, "disease": "", "pathway": " (rno:499520)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AB47-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AB86-1", "uniprot_id": [ { "id": "D4AB86_RAT", "url": "https://www.uniprot.org/uniprot/D4AB86", "type": "external" } ], "mass": 35068.0, "length": 313, "protein_name": "Olfactory receptor", "gene_name": "Or1x2", "organism": "Rat", "refseq_name": "olfactory receptor Olr1409", "refseq_ac": [ { "id": "NP_001000004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000004", "type": "external" } ], "gene_names_uniprotkb": "Or1x2", "gene_names_refseq": "Olr1409; Or1x2", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1409; olfactory receptor Olr1409; olfactory receptor gene Olr1409", "tax_id": 10116, "disease": "", "pathway": " (rno:287259)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AB86-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ABD9-1", "uniprot_id": [ { "id": "D4ABD9_RAT", "url": "https://www.uniprot.org/uniprot/D4ABD9", "type": "external" } ], "mass": 15374.0, "length": 134, "protein_name": "Retinol binding protein 7", "gene_name": "Rbp7", "organism": "Rat", "refseq_name": "retinoid-binding protein 7", "refseq_ac": [ { "id": "NP_001102163", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102163", "type": "external" } ], "gene_names_uniprotkb": "Rbp7", "gene_names_refseq": "RGD1562168; 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Or5p66; ratchr1-165882706-165881765_ORF", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 259; olfactory receptor Olr259; olfactory receptor gene Olr259", "tax_id": 10116, "disease": "", "pathway": " (rno:293402)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Required for efficient rRNA processing and 60S ribosomal subunit biogenesis. Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes. 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Or8k20; ratchr3-69329359-69328433_ORF", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 488; olfactory receptor Olr488; olfactory receptor gene Olr488", "tax_id": 10116, "disease": "", "pathway": " (rno:295754)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity. The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. 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Zdhhc20", "protein_names_uniprotkb": "Palmitoyltransferase; 2.3.1.225", "protein_names_refseq": "palmitoyltransferase ZDHHC20 isoform X1", "tax_id": 10116, "disease": "syndrome (Disease Ontology:DOID:225)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006974 DNA damage response;GO:0044794 host-mediated activation of viral process;GO:0018345 protein palmitoylation;GO:0018230 peptidyl-L-cysteine S-palmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E9PT74-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PT92-1", "uniprot_id": [ { "id": "E9PT92_RAT", "url": "https://www.uniprot.org/uniprot/E9PT92", "type": "external" } ], "mass": 387834.0, "length": 3564, "protein_name": "CUB and Sushi multiple domains 1", "gene_name": "Csmd1", "organism": "Rat", "refseq_name": "CUB and sushi domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_001032404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032404", "type": "external" } ], "gene_names_uniprotkb": "Csmd1", "gene_names_refseq": "Csmd1; Mdcr1", "protein_names_uniprotkb": "CUB and Sushi multiple domains 1", "protein_names_refseq": "CUB and sushi domain-containing protein 1 precursor; CUB and sushi domain-containing protein 1; multiple domain complement regulator 1", "tax_id": 10116, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:364634)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16547280;38843836", "class_list": "", "function": "CSMD1 may be an important regulator of complement activation and inflammation in the developing central nervous system, and that it may also play a role in the context of growth cone function GeneRIF: the rat homolog of CSMD1 has complement inhibiting activity and is located in neuron growth cones., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0060603 mammary gland duct morphogenesis;GO:0060745 mammary gland branching involved in pregnancy;GO:0001964 startle response;GO:0007613 memory;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E9PT92-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PTB6-1", "uniprot_id": [ { "id": "E9PTB6_RAT", "url": "https://www.uniprot.org/uniprot/E9PTB6", "type": "external" } ], "mass": 155847.0, "length": 1390, "protein_name": "DNA-directed RNA polymerase subunit", "gene_name": "Polr3a", "organism": "Rat", "refseq_name": "DNA-directed RNA polymerase III subunit RPC1", "refseq_ac": [ { "id": "NP_001401818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401818", "type": "external" } ], "gene_names_uniprotkb": "Polr3a", "gene_names_refseq": "Polr3a; RGD1305574", "protein_names_uniprotkb": "DNA-directed RNA polymerase subunit; 2.7.7.6", "protein_names_refseq": "DNA-directed RNA polymerase III subunit RPC1; polymerase (RNA) III (DNA directed) polypeptide A, 155kDa; polymerase (RNA) III subunit A", "tax_id": 10116, "disease": "hypomyelinating leukodystrophy (Disease Ontology:DOID:0060786); hypomyelinating leukodystrophy 7 (Disease Ontology:DOID:0060794); Wiedemann-Rautenstrauch syndrome (Disease Ontology:DOID:0081333)", "pathway": " (R-RNO-76061); (R-RNO-76066); (R-RNO-76071)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0003899 DNA-directed RNA polymerase activity;GO:0000287 magnesium ion binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0031981 nuclear lumen;GO:0005666 RNA polymerase III complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0042797 tRNA transcription by RNA polymerase III;GO:0045087 innate immune response;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E9PTB6-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PTI0-1", "uniprot_id": [ { "id": "E9PTI0_RAT", "url": "https://www.uniprot.org/uniprot/E9PTI0", "type": "external" } ], "mass": 16627.0, "length": 145, "protein_name": "Serine peptidase inhibitor, Kunitz type 5", "gene_name": "Spint5p", "organism": "Rat", "refseq_name": "serine peptidase inhibitor, Kunitz type 5 precursor", "refseq_ac": [ { "id": "NP_001382050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382050", "type": "external" } ], "gene_names_uniprotkb": "Spint5p", "gene_names_refseq": "Spint5p; Tpil4", "protein_names_uniprotkb": "Serine peptidase inhibitor, Kunitz type 5", "protein_names_refseq": "serine peptidase inhibitor, Kunitz type 5 precursor; trypsin protease inhibitor-like 4", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E9PTI0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PTL5-1", "uniprot_id": [ { "id": "E9PTL5_RAT", "url": "https://www.uniprot.org/uniprot/E9PTL5", "type": "external" } ], "mass": 92616.0, "length": 808, "protein_name": "Toll-like receptor 1", "gene_name": "Tlr1", "organism": "Rat", "refseq_name": "toll-like receptor 1 isoform X1", "refseq_ac": [ { "id": "XP_038947853", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038947853", "type": "external" } ], "gene_names_uniprotkb": "Tlr1", "gene_names_refseq": "Tlr1", "protein_names_uniprotkb": "Toll-like receptor 1", "protein_names_refseq": "toll-like receptor 1 isoform X1", "tax_id": 10116, "disease": "leprosy (Disease Ontology:DOID:1024); pyelonephritis (Disease Ontology:DOID:11400); aspergillosis (Disease Ontology:DOID:13564); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); tuberculosis (Disease Ontology:DOID:399); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677)", "pathway": " (R-RNO-1461957); (R-RNO-5686938)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0071723 lipopeptide binding;GO:0038023 signaling receptor activity;GO:0035663 Toll-like receptor 2 binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0044853 plasma membrane raft;GO:0045121 membrane raft", "go_biological_process": "GO:0001774 microglial cell activation;GO:0006952 defense response;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0032755 positive regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E9PTL5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PU10-1", "uniprot_id": [ { "id": "E9PU10_RAT", "url": "https://www.uniprot.org/uniprot/E9PU10", "type": "external" } ], "mass": 47432.0, "length": 420, "protein_name": "Interferon gamma inducible protein 47", "gene_name": "Ifi47", "organism": "Rat", "refseq_name": "interferon gamma inducible protein 47", "refseq_ac": [ { "id": "NP_742016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742016", "type": "external" } ], "gene_names_uniprotkb": "Ifi47", "gene_names_refseq": "Ifi47", "protein_names_uniprotkb": "Interferon gamma inducible protein 47", "protein_names_refseq": "interferon gamma inducible protein 1; interferon gamma inducible protein 47", "tax_id": 10116, "disease": "", "pathway": " (rno:246208)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MAC0", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0045087 innate immune response;GO:0035458 cellular response to interferon-beta", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E9PU10-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PU21-1", "uniprot_id": [ { "id": "E9PU21_RAT", "url": "https://www.uniprot.org/uniprot/E9PU21", "type": "external" } ], "mass": 16631.0, "length": 161, "protein_name": "DNA-binding protein inhibitor ID-4", "gene_name": "Id4", "organism": "Rat", "refseq_name": "DNA-binding protein inhibitor ID-4", "refseq_ac": [ { "id": "NP_783172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783172", "type": "external" } ], "gene_names_uniprotkb": "Id4", "gene_names_refseq": "Id4; Idb4", "protein_names_uniprotkb": "DNA-binding protein inhibitor ID-4; Inhibitor of DNA binding 4; Inhibitor of differentiation 4", "protein_names_refseq": "DNA-binding protein inhibitor ID-4; inhibitor of DNA binding 4, HLH protein; inhibitor of DNA binding 4, dominant negative helix-loop-helix protein", "tax_id": 10116, "disease": "osteoporosis (Disease Ontology:DOID:11476)", "pathway": " (rno:291023)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14633621;21132377;21543770;22041901;28278052", "class_list": "", "function": "Astrocytes can cause Ca(2+) signaling activation, ERK1/2 phosphorylation, and Id4 expression stimulation in oligodendrocyte progenitor cells inducing proliferation of these cells, mainly through Cx47., [RefSeq, PubMed]; Bimolecular fluorescence complementation (BiFC) analysis was performed to further characterize the distinct subcellular localization of olig1, ID4 and their dimer., [RefSeq, PubMed]; CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 and were hypomethylated in PRMT5-deficient cells, suggesting that PRMT5 plays a role in gene silencing during glial cell, [RefSeq, PubMed]; Id4 may contribute to carcinogenesis by inhibiting mammary epithelial cell differentiation and stimulating mammary epithelial cell growth, [RefSeq, PubMed]; These results indicate that ID4 is a distinguishing marker of spermatogonial stem cells in the mammalian germline and plays an important role in the regulation of self-renewal., [RefSeq, PubMed]; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0003714 transcription corepressor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030182 neuron differentiation;GO:0060741 prostate gland stromal morphogenesis;GO:0061682 seminal vesicle morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E9PU21-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PU79-1", "uniprot_id": [ { "id": "E9PU79_RAT", "url": "https://www.uniprot.org/uniprot/E9PU79", "type": "external" } ], "mass": 9171.0, "length": 91, "protein_name": "Salivary protein 1", "gene_name": "Spt1", "organism": "Rat", "refseq_name": "salivary protein 1 precursor", "refseq_ac": [ { "id": "NP_062044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062044", "type": "external" } ], "gene_names_uniprotkb": "Spt1; LOC102555445; LOC134479615; Spt1l1", "gene_names_refseq": "Spt1", "protein_names_uniprotkb": "Salivary protein 1", "protein_names_refseq": "salivary protein 1 precursor", "tax_id": 10116, "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454); myofibrillar myopathy 5 (Disease Ontology:DOID:0080096); X-linked chronic idiopathic intestinal pseudo-obstruction (Disease Ontology:DOID:0080681); distal myopathy 4 (Disease Ontology:DOID:0111190); X-linked cardiac valvular dysplasia (Disease Ontology:DOID:0111765); otopalatodigital syndrome spectrum disorder (Disease Ontology:DOID:0111782); otopalatodigital syndrome type 1 (Disease Ontology:DOID:0111783); otopalatodigital syndrome type 2 (Disease Ontology:DOID:0111784); frontometaphyseal dysplasia 1 (Disease Ontology:DOID:0111786); Melnick-Needles syndrome (Disease Ontology:DOID:0111788); terminal osseous dysplasia (Disease Ontology:DOID:0112149); tuberous sclerosis (Disease Ontology:DOID:13515); thoracic aortic aneurysm (Disease Ontology:DOID:14004); epilepsy (Disease Ontology:DOID:1826); osteochondrodysplasia (Disease Ontology:DOID:2256); craniosynostosis (Disease Ontology:DOID:2340); myopathy (Disease Ontology:DOID:423); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (rno:29229)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M0R9H2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E9PU79-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LLV4-1", "uniprot_id": [ { "id": "F1LLV4_RAT", "url": "https://www.uniprot.org/uniprot/F1LLV4", "type": "external" } ], "mass": 39057.0, "length": 343, "protein_name": "MAS-related GPR, member B3", "gene_name": "Mrgprb3", "organism": "Rat", "refseq_name": "MAS-related GPR, member B3", "refseq_ac": [ { "id": "NP_001419578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001419578", "type": "external" } ], "gene_names_uniprotkb": "Mrgprb3", "gene_names_refseq": "MrgB3; Mrgprb3", "protein_names_uniprotkb": "MAS-related GPR, member B3", "protein_names_refseq": "MAS-related G protein-coupled receptor, member B3; MAS-related GPR, member B3; MAS-related gene B3; mas-related G-protein coupled receptor member X2", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LLV4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LMU5-1", "uniprot_id": [ { "id": "F1LMU5_RAT", "url": "https://www.uniprot.org/uniprot/F1LMU5", "type": "external" } ], "mass": 50899.0, "length": 449, "protein_name": "Zinc finger and BTB domain-containing protein 14", "gene_name": "Zbtb14", "organism": "Rat", "refseq_name": "zinc finger and BTB domain-containing protein 14", "refseq_ac": [ { "id": "NP_758828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758828", "type": "external" } ], "gene_names_uniprotkb": "Zbtb14", "gene_names_refseq": "Zbtb14; Zf5; Zfp161", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 14", "protein_names_refseq": "zinc finger and BTB domain-containing protein 14; zinc finger protein 161 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:282825)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15620221;22673903", "class_list": "", "function": "Single exon, start codon in a separate exon. Expressed at high levels in spleen, brain, lung and kidney., [RefSeq, PubMed]; Transcriptional activator of the dopamine transporter (DAT), binding its promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0003170 heart valve development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0001822 kidney development;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1LMU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LNZ3-1", "uniprot_id": [ { "id": "F1LNZ3_RAT", "url": "https://www.uniprot.org/uniprot/F1LNZ3", "type": "external" } ], "mass": 85993.0, "length": 740, "protein_name": "Zinc finger protein 347", "gene_name": "Zfp347", "organism": "Rat", "refseq_name": "zinc finger protein 347 isoform 2", "refseq_ac": [ { "id": "NP_001417144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001417144", "type": "external" } ], "gene_names_uniprotkb": "Zfp347", "gene_names_refseq": "Giot2; Zfp347", "protein_names_uniprotkb": "Zinc finger protein 347", "protein_names_refseq": "gonadotropin inducible ovarian transcription factor 2; zinc finger protein 347 isoform 2", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LNZ3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZAZ5-1", "uniprot_id": [ { "id": "BCAR3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZAZ5", "type": "external" } ], "mass": 92477.0, "length": 825, "protein_name": "Breast cancer anti-estrogen resistance protein 3 homolog", "gene_name": "Bcar3", "organism": "Rat", "refseq_name": "breast cancer anti-estrogen resistance protein 3 homolog", "refseq_ac": [ { "id": "NP_001101192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101192", "type": "external" } ], "gene_names_uniprotkb": "Bcar3", "gene_names_refseq": "Bcar3", "protein_names_uniprotkb": "Breast cancer anti-estrogen resistance protein 3 homolog; BCAR3 adapter protein, NSP family member; Novel SH2-containing protein 2; SH2 domain-containing protein 3B; p130Cas-binding protein AND-34", "protein_names_refseq": "BCAR3 adapter protein, NSP family member; BCAR3, NSP family adaptor protein 3; SH2 domain-containing protein 3B; breast cancer anti-estrogen resistance 3; breast cancer anti-estrogen resistance protein 3 homolog; novel SH2-containing protein 2; p130Cas-binding protein AND-34", "tax_id": 10116, "disease": "", "pathway": " (rno:310838)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;22801373;24216110", "class_list": "", "function": "Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (By similarity). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (PubMed:24216110). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (By similarity). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB/SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (By similarity). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Study described a molecular complex of PTPalpha-BCAR3-Cas-Src; this complex forms in response to PTPalpha Tyr789 phosphorylation and mediates Cas localization to focal adhesions and Cas downstream signaling to promote cell migration, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0019900 kinase binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005925 focal adhesion;GO:0016020 membrane", "go_biological_process": "GO:0086100 endothelin receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0033138 positive regulation of peptidyl-serine phosphorylation;GO:0043410 positive regulation of MAPK cascade;GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZAZ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1WBP0-1", "uniprot_id": [ { "id": "MPPD2_RAT", "url": "https://www.uniprot.org/uniprot/B1WBP0", "type": "external" } ], "mass": 33336.0, "length": 294, "protein_name": "Metallophosphoesterase MPPED2", "gene_name": "Mpped2", "organism": "Rat", "refseq_name": "metallophosphoesterase MPPED2", "refseq_ac": [ { "id": "NP_942073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942073", "type": "external" } ], "gene_names_uniprotkb": "Mpped2", "gene_names_refseq": "C11orf8h; C11orf8; Mpped2", "protein_names_uniprotkb": "Metallophosphoesterase MPPED2; 239FB; 3.1.-.-; Fetal brain protein 239 homolog; Metallophosphoesterase domain-containing protein 2", "protein_names_refseq": "239FB; fetal brain protein 239 homolog; metallophosphoesterase MPPED2; metallophosphoesterase domain-containing protein 2; putative C11orf8 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:362185)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19004815;21824479", "class_list": "", "function": "Displays low metallophosphoesterase activity (in vitro) (PubMed:19004815, PubMed:21824479). May play a role in the development of the nervous system (Probable)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFG1", "ec_number_list": [], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0016208 AMP binding;GO:0008081 phosphoric diester hydrolase activity;GO:0004112 cyclic-nucleotide phosphodiesterase activity;GO:0019002 GMP binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B1WBP0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JTZ2-1", "uniprot_id": [ { "id": "SOX6_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JTZ2", "type": "external" } ], "mass": 91816.0, "length": 827, "protein_name": "Transcription factor SOX-6", "gene_name": "Sox6", "organism": "Rat", "refseq_name": "transcription factor SOX-6", "refseq_ac": [ { "id": "NP_001019922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019922", "type": "external" } ], "gene_names_uniprotkb": "Sox6; Sox-6", "gene_names_refseq": "Sox6", "protein_names_uniprotkb": "Transcription factor SOX-6", "protein_names_refseq": "SRY (sex determining region Y)-box 6; SRY box 6; SRY-box containing gene 6; transcription factor SOX-6", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); heart disease (Disease Ontology:DOID:114); high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (rno:293165); (R-RNO-3769402)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12081133;26150426;26659076;31076992;32114773", "class_list": "", "function": "LncRNA Gm4419 induces cell apoptosis in hepatic ischemia-reperfusion injury via regulating the miR-455-SOX6 axis., [RefSeq, PubMed]; Sox6 was specifically expressed in the neonatal brain and adult testis with Northern blotting., [RefSeq, PubMed]; The apoptosis process enhanced by overexpression of SOX6 or PDCD4, was rescued by the cardiac-abundant miR-499 in rat cardiomyocytes., [RefSeq, PubMed]; The authors proved that miR-499-5p inhibited hypoxia/reoxygenation-induced cardiomyocytes injury by targeting SOX6., [RefSeq, PubMed]; Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (By similarity). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis (By similarity). Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate (PubMed:26150426). Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts (By similarity). Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MAJ5;Q4V8G3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A0G2JTZ2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M2M1-1", "uniprot_id": [ { "id": "F1M2M1_RAT", "url": "https://www.uniprot.org/uniprot/F1M2M1", "type": "external" } ], "mass": 56526.0, "length": 505, "protein_name": "Gamma-1-syntrophin", "gene_name": "Sntg1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sntg1", "gene_names_refseq": "", "protein_names_uniprotkb": "Gamma-1-syntrophin; Syntrophin-4", "protein_names_refseq": "", "tax_id": 10116, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (rno:500394)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0032587 ruffle membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M2M1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZE26-1", "uniprot_id": [ { "id": "D3ZE26_RAT", "url": "https://www.uniprot.org/uniprot/D3ZE26", "type": "external" } ], "mass": 77143.0, "length": 706, "protein_name": "Transmembrane and coiled-coil domain family 2", "gene_name": "Tmcc2", "organism": "Rat", "refseq_name": "transmembrane and coiled-coil domains protein 2", "refseq_ac": [ { "id": "NP_001292057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292057", "type": "external" } ], "gene_names_uniprotkb": "Tmcc2", "gene_names_refseq": "RGD1311960; Tmcc2", "protein_names_uniprotkb": "Transmembrane and coiled-coil domain family 2", "protein_names_refseq": "transmembrane and coiled-coil domains 2; transmembrane and coiled-coil domains protein 2", "tax_id": 10116, "disease": "alcohol-related neurodevelopmental disorder (Disease Ontology:DOID:0050667)", "pathway": " (rno:305095)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16641100;22673903;38843836", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0005783 endoplasmic reticulum;GO:0012505 endomembrane system", "go_biological_process": "GO:0042982 amyloid precursor protein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D3ZE26-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M805-1", "uniprot_id": [ { "id": "F1M805_RAT", "url": "https://www.uniprot.org/uniprot/F1M805", "type": "external" } ], "mass": 70421.0, "length": 597, "protein_name": "UTP6 small subunit processome component", "gene_name": "Utp6", "organism": "Rat", "refseq_name": "U3 small nucleolar RNA-associated protein 6 homolog", "refseq_ac": [ { "id": "NP_001385732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385732", "type": "external" } ], "gene_names_uniprotkb": "Utp6", "gene_names_refseq": "RGD1311017; Utp6", "protein_names_uniprotkb": "UTP6 small subunit processome component", "protein_names_refseq": "U3 small nucleolar RNA-associated protein 6 homolog; UTP6, small subunit (SSU) processome component, homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:360574); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030515 snoRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0034388 Pwp2p-containing subcomplex of 90S preribosome;GO:0005694 chromosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M805-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V9P8-1", "uniprot_id": [ { "id": "G3V9P8_RAT", "url": "https://www.uniprot.org/uniprot/G3V9P8", "type": "external" } ], "mass": 69180.0, "length": 610, "protein_name": "Poly [ADP-ribose] polymerase", "gene_name": "Parp6", "organism": "Rat", "refseq_name": "protein mono-ADP-ribosyltransferase PARP6 isoform X4", "refseq_ac": [ { "id": "XP_008764455", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008764455", "type": "external" } ], "gene_names_uniprotkb": "Parp6", "gene_names_refseq": "Parp6; RGD1310937", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase; 2.4.2.-; PARP", "protein_names_refseq": "protein mono-ADP-ribosyltransferase PARP6 isoform X4", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" } ], "go_molecular_function": "GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0019900 kinase binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0140803 NAD+-protein-cysteine ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0016020 membrane;GO:0071782 endoplasmic reticulum tubular network", "go_biological_process": "GO:0070213 protein auto-ADP-ribosylation;GO:0050775 positive regulation of dendrite morphogenesis;GO:0030968 endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V9P8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZBQ5-1", "uniprot_id": [ { "id": "D3ZBQ5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZBQ5", "type": "external" } ], "mass": 88614.0, "length": 838, "protein_name": "Scavenger receptor class F, member 2", "gene_name": "Scarf2", "organism": "Rat", "refseq_name": "scavenger receptor class F member 2 isoform X1", "refseq_ac": [ { "id": "XP_038944006", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038944006", "type": "external" } ], "gene_names_uniprotkb": "Scarf2", "gene_names_refseq": "Scarf2", "protein_names_uniprotkb": "Scavenger receptor class F, member 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The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, 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"7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity;GO:0140358 P-type transmembrane transporter activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0006874 intracellular calcium ion 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isoform 1; E3 ubiquitin-protein ligase makorin-1", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-198323); (R-RNO-8948751); (R-RNO-983168)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "22128154;33647316", "class_list": "", "function": "Identification of MKRN1 as a second E3 ligase for Eag1 potassium channels reveals regulation via differential degradation., [RefSeq, PubMed]; In mammalian neurons MKRN1-short interacts with PABP to locally control the translation of dendritic mRNAs at synapses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, 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"id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0003682 chromatin binding", "go_cellular_component": "", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:1990830 cellular response to leukemia inhibitory factor;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0G2QC40-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7DLY1-1", "uniprot_id": [ { "id": "F7DLY1_RAT", "url": "https://www.uniprot.org/uniprot/F7DLY1", "type": "external" } ], "mass": 82276.0, "length": 729, "protein_name": "Epidermal growth factor receptor kinase substrate 8-like protein 2", "gene_name": "Eps8l2", "organism": "Rat", "refseq_name": "epidermal growth factor receptor kinase 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In the cochlea, is required for stereocilia maintenance in adult hair cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RYJ9", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032587 ruffle membrane;GO:0032991 protein-containing complex;GO:0032426 stereocilium tip", "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:0007605 sensory perception of sound;GO:1900029 positive regulation of ruffle assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F7DLY1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V6B9-1", "uniprot_id": [ { "id": "G3V6B9_RAT", "url": "https://www.uniprot.org/uniprot/G3V6B9", "type": "external" } ], "mass": 106555.0, "length": 933, "protein_name": "Tyrosine-protein phosphatase non-receptor type", "gene_name": "Ptpn4", "organism": "Rat", "refseq_name": "tyrosine-protein phosphatase non-receptor type 4 isoform X1", "refseq_ac": [ { "id": "XP_017454155", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017454155", "type": "external" } ], "gene_names_uniprotkb": "Ptpn4", "gene_names_refseq": "Ptpn4", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type; 3.1.3.48", "protein_names_refseq": "tyrosine-protein phosphatase non-receptor type 4 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-166016)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act at junctions between the membrane and the cytoskeleton., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" } ], "go_molecular_function": "GO:0008092 cytoskeletal protein binding;GO:0004725 protein tyrosine phosphatase activity;GO:0035254 glutamate receptor binding;GO:0004726 non-membrane spanning protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005856 cytoskeleton;GO:0009898 cytoplasmic side of plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0018108 peptidyl-tyrosine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V6B9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z9K6-1", "uniprot_id": [ { "id": "D3Z9K6_RAT", "url": "https://www.uniprot.org/uniprot/D3Z9K6", "type": "external" } ], "mass": 19221.0, "length": 172, "protein_name": "Family with sequence similarity 180, member A", "gene_name": "Fam180a", "organism": "Rat", "refseq_name": "protein FAM180A precursor", "refseq_ac": [ { "id": "NP_001102091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102091", "type": "external" } ], "gene_names_uniprotkb": "Fam180a", "gene_names_refseq": "Fam180a; RGD1308013", "protein_names_uniprotkb": "Family with sequence similarity 180, member A", "protein_names_refseq": "protein FAM180A precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:362336)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3Z9K6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z9D3-1", "uniprot_id": [ { "id": "D3Z9D3_RAT", "url": "https://www.uniprot.org/uniprot/D3Z9D3", "type": "external" } ], "mass": 37629.0, "length": 323, "protein_name": "BRMS1 like transcriptional repressor", "gene_name": "Brms1l", "organism": "Rat", "refseq_name": "breast cancer metastasis-suppressor 1-like protein", "refseq_ac": [ { "id": "NP_001382015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382015", "type": "external" } ], "gene_names_uniprotkb": "Brms1l", "gene_names_refseq": "Brms1l", "protein_names_uniprotkb": "BRMS1 like transcriptional repressor", "protein_names_refseq": "breast cancer metastasis-suppressor 1-like protein", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0070822 Sin3-type complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3Z9D3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z900-1", "uniprot_id": [ { "id": "D3Z900_RAT", "url": "https://www.uniprot.org/uniprot/D3Z900", "type": "external" } ], "mass": 37791.0, "length": 339, "protein_name": "Mitochondrial amidoxime reducing component 1", "gene_name": "Mtarc1", "organism": "Rat", "refseq_name": "mitochondrial amidoxime-reducing component 1", "refseq_ac": [ { "id": "NP_001094281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094281", "type": "external" } ], "gene_names_uniprotkb": "Mtarc1", "gene_names_refseq": "Marc1; Mosc1; Mtarc1", "protein_names_uniprotkb": "Mitochondrial amidoxime reducing component 1", "protein_names_refseq": "MOCO sulphurase C-terminal domain containing 1; mitochondrial amidoxime-reducing component 1", "tax_id": 10116, "disease": "", "pathway": " (rno:690745)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3V6I4", "ec_number_list": [], "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0008940 nitrate reductase activity;GO:0030170 pyridoxal phosphate binding;GO:0043546 molybdopterin cofactor binding;GO:0050421 nitrite reductase (NO-forming) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:1903958 nitric-oxide synthase complex", "go_biological_process": "GO:0006809 nitric oxide biosynthetic process;GO:0042126 nitrate metabolic process;GO:0070458 cellular detoxification of nitrogen compound", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3Z900-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG01-1", "uniprot_id": [ { "id": "Q6MG01_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG01", "type": "external" } ], "mass": 45134.0, "length": 393, "protein_name": "RT1 class Ib, locus N3", "gene_name": "RT1-N3", "organism": "Rat", "refseq_name": "RT1 class Ib, locus N3", "refseq_ac": [ { "id": "NP_001008855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008855", "type": "external" } ], "gene_names_uniprotkb": "RT1-N3", "gene_names_refseq": "RT1-N3", "protein_names_uniprotkb": "RT1 class Ib, locus N3", "protein_names_refseq": "RT1 class Ib gene, H2-TL-like, grc region (N3); RT1 class Ib, locus N3", "tax_id": 10116, "disease": "", "pathway": " (rno:24750); (R-RNO-1236974); (R-RNO-1236977); (R-RNO-198933); (R-RNO-6798695); (R-RNO-983170)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F6PT03;G5EBE1;H7C829;I1SB24;L7N646;Q31280;U3KRG4;V9HVV1", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030881 beta-2-microglobulin binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0030670 phagocytic vesicle membrane;GO:0042612 MHC class I protein complex;GO:0098553 lumenal side of endoplasmic reticulum membrane", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0006955 immune response;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity;GO:0002474 antigen processing and presentation of peptide antigen via MHC class I", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6MG01-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RCP2-1", "uniprot_id": [ { "id": "M0RCP2_RAT", "url": "https://www.uniprot.org/uniprot/M0RCP2", "type": "external" } ], "mass": 104580.0, "length": 935, "protein_name": "SH3 and PX domain-containing protein 2B", "gene_name": "Sh3pxd2b", "organism": "Rat", "refseq_name": "SH3 and PX domain-containing protein 2B isoform X1", "refseq_ac": [ { "id": "XP_017453105", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017453105", "type": "external" } ], "gene_names_uniprotkb": "Sh3pxd2b; RGD1309926", "gene_names_refseq": "RGD1309926; Sh3pxd2b", "protein_names_uniprotkb": "SH3 and PX domain-containing protein 2B; Factor for adipocyte differentiation 49; Tyrosine kinase substrate with four SH3 domains", "protein_names_refseq": "SH3 and PX domain-containing protein 2B isoform X1", "tax_id": 10116, "disease": "Frank-Ter Haar syndrome (Disease Ontology:DOID:0111789); otitis media (Disease Ontology:DOID:10754); glaucoma (Disease Ontology:DOID:1686)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0042169 SH2 domain binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0002102 podosome", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0002051 osteoblast fate commitment;GO:1904179 positive regulation of adipose tissue development;GO:0060378 regulation of brood size;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RCP2-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M2W3-1", "uniprot_id": [ { "id": "F1M2W3_RAT", "url": "https://www.uniprot.org/uniprot/F1M2W3", "type": "external" } ], "mass": 14432.0, "length": 133, "protein_name": "Ig-like domain-containing protein", "gene_name": "AABR07060872.1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AABR07060872.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig-like domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "34502162", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1M2W3-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35559-1", "uniprot_id": [ { "id": "IDE_RAT", "url": "https://www.uniprot.org/uniprot/P35559", "type": "external" } ], "mass": 117710.0, "length": 1019, "protein_name": "Insulin-degrading enzyme", "gene_name": "Ide", "organism": "Rat", "refseq_name": "insulin-degrading enzyme", "refseq_ac": [ { "id": "NP_037291", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037291", "type": "external" } ], "gene_names_uniprotkb": "Ide", "gene_names_refseq": "INSDEGM; Ide", "protein_names_uniprotkb": "Insulin-degrading enzyme; 3.4.24.56; Insulin protease; Insulinase; Insulysin", "protein_names_refseq": "insulin protease; insulin-degrading enzyme; insulinase; insulysin", "tax_id": 10116, "disease": "diabetic encephalopathy (Disease Ontology:DOID:0050850); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); cancer (Disease Ontology:DOID:162); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:25700); (R-RNO-5689880); (R-RNO-77387); (R-RNO-9033241)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10684867;12941771;1445854;14527953;1836994;21731629;22049080;29263141;29940507;7678795;8425612", "class_list": "", "function": "Data suggest that insulin deprivation, rather than high glucose, is a significant determinant of IDE regulation; as evidence indicates potential roles for IDE in diabetes and Alzheimer's disease, understanding the mechanisms regulating IDE expression may be important in developing new treatment strategies, [RefSeq, PubMed]; GLP-1R regulates cell growth, at least partially, through regulating cAMP/PKA/IDE signaling pathway in ABETA(1-42)-treated PC12 cells. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling (PubMed:10684867, PubMed:12941771, PubMed:1445854, PubMed:14527953, PubMed:1836994, PubMed:22049080). Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (By similarity). Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP (By similarity). Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (PubMed:10684867). Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP (By similarity). Also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA) which is associated with familial atrial fibrillation in heterozygous patients (By similarity). Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0031626 beta-endorphin binding;GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031597 cytosolic proteasome complex;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0010992 ubiquitin recycling;GO:1901142 insulin metabolic process;GO:0006508 proteolysis;GO:0006979 response to oxidative stress;GO:0050435 amyloid-beta metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P35559-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DEP5-1", "uniprot_id": [ { "id": "B5DEP5_RAT", "url": "https://www.uniprot.org/uniprot/B5DEP5", "type": "external" } ], "mass": 65852.0, "length": 581, "protein_name": "Activating signal cointegrator 1", "gene_name": "Trip4", "organism": "Rat", "refseq_name": "activating signal cointegrator 1", "refseq_ac": [ { "id": "NP_001128453", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128453", "type": "external" } ], "gene_names_uniprotkb": "Trip4", "gene_names_refseq": "Trip4", "protein_names_uniprotkb": "Activating signal cointegrator 1; Thyroid receptor-interacting protein 4", "protein_names_refseq": "activating signal cointegrator 1", "tax_id": 10116, "disease": "", "pathway": " (rno:315769); (R-RNO-9954716)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation. Also involved in androgen receptor transactivation. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. May play a role in the development of neuromuscular junction. May play a role in late myogenic differentiation. Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, 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DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B5DEP5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JWT6-1", "uniprot_id": [ { "id": "A0A0G2JWT6_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JWT6", "type": "external" } ], "mass": 38601.0, "length": 336, "protein_name": "Peroxisomal membrane protein PEX16", "gene_name": "Pex16", "organism": "Rat", "refseq_name": "peroxisomal biogenesis factor 16", "refseq_ac": [ { "id": "NP_001012088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012088", "type": "external" } ], "gene_names_uniprotkb": "Pex16", "gene_names_refseq": "Pex16", "protein_names_uniprotkb": "Peroxisomal membrane protein PEX16", "protein_names_refseq": "peroxisomal biogenesis factor 16; peroxisome biogenesis factor 16", "tax_id": 10116, "disease": "peroxisome biogenesis disorder 8A (Disease Ontology:DOID:0080483); Peroxisome biogenesis disorder 8B (Disease Ontology:DOID:0081437)", "pathway": " (rno:311203); (R-RNO-9603798)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005778 peroxisomal membrane;GO:0005777 peroxisome;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007031 peroxisome organization;GO:0006625 protein targeting to peroxisome;GO:0016558 protein import into peroxisome matrix;GO:0016557 peroxisome membrane biogenesis;GO:0022615 protein to membrane docking", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JWT6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RBW2-1", "uniprot_id": [ { "id": "M0RBW2_RAT", "url": "https://www.uniprot.org/uniprot/M0RBW2", "type": "external" } ], "mass": 209195.0, "length": 1850, "protein_name": "Cilia and flagella associated protein 65", "gene_name": "Cfap65", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cfap65", "gene_names_refseq": "", "protein_names_uniprotkb": "Cilia and flagella associated protein 65", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031514 motile cilium;GO:1990716 axonemal central apparatus;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0001675 acrosome assembly;GO:0003341 cilium movement;GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "M0RBW2-1", "record_type": "protein", "filter_code": "0000000.1000100.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LSN4-1", "uniprot_id": [ { "id": "F1LSN4_RAT", "url": "https://www.uniprot.org/uniprot/F1LSN4", "type": "external" } ], "mass": 87793.0, "length": 801, "protein_name": "Fibroblast growth factor receptor", "gene_name": "Fgfr3", "organism": "Rat", "refseq_name": "fibroblast growth factor receptor 3 isoform X3", "refseq_ac": [ { "id": "XP_006251457", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006251457", "type": "external" } ], "gene_names_uniprotkb": "Fgfr3", "gene_names_refseq": "Fgfr3", "protein_names_uniprotkb": "Fibroblast growth factor receptor; 2.7.10.1", "protein_names_refseq": "fibroblast growth factor receptor 3 isoform X3", "tax_id": 10116, "disease": "autosomal dominant disease (Disease Ontology:DOID:0050736); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); tonsil squamous cell carcinoma (Disease Ontology:DOID:0050920); scoliosis (Disease Ontology:DOID:0060249); Muenke Syndrome (Disease Ontology:DOID:0060703); bone disease (Disease Ontology:DOID:0080001); hypochondroplasia (Disease Ontology:DOID:0080041); lacrimoauriculodentodigital syndrome 2 (Disease Ontology:DOID:0081371); SADDAN (Disease Ontology:DOID:0111158); camptodactyly-tall stature-scoliosis-hearing loss syndrome (Disease Ontology:DOID:0111160); Crouzon syndrome-acanthosis nigricans syndrome (Disease Ontology:DOID:0111161); epidermal nevus (Disease Ontology:DOID:0111162); urinary bladder cancer (Disease Ontology:DOID:11054); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); thanatophoric dysplasia (Disease Ontology:DOID:13481); breast cancer (Disease Ontology:DOID:1612); craniosynostosis (Disease Ontology:DOID:2340); transitional cell carcinoma (Disease Ontology:DOID:2671); cervix carcinoma (Disease Ontology:DOID:2893); high grade glioma (Disease Ontology:DOID:3070); acanthosis nigricans (Disease Ontology:DOID:3138); chondrosarcoma (Disease Ontology:DOID:3371); Merkel cell carcinoma (Disease Ontology:DOID:3965); bladder urothelial carcinoma (Disease Ontology:DOID:4006); achondroplasia (Disease Ontology:DOID:4480); chronic myeloid leukemia (Disease Ontology:DOID:8552); tongue cancer (Disease Ontology:DOID:8649); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-RNO-109704); (R-RNO-1257604); (R-RNO-190371); (R-RNO-190372); (R-RNO-5654227); (R-RNO-5654704); (R-RNO-5654706); (R-RNO-5654710); (R-RNO-5654732); (R-RNO-5673001); (R-RNO-6811558)", "pathway_count": 11, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0017134 fibroblast growth factor binding;GO:0004713 protein tyrosine kinase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030133 transport vesicle;GO:0009986 cell surface", "go_biological_process": "GO:0008283 cell population proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0060349 bone morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1LSN4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JTL1-1", "uniprot_id": [ { "id": "A0A0G2JTL1_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JTL1", "type": "external" } ], "mass": 33628.0, "length": 292, "protein_name": "Tripartite motif containing 15", "gene_name": "Trim15", "organism": "Rat", "refseq_name": "tripartite motif-containing protein 15", "refseq_ac": [ { "id": "NP_001278311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278311", "type": "external" } ], "gene_names_uniprotkb": "Trim15", "gene_names_refseq": "Trim15", "protein_names_uniprotkb": "Tripartite motif containing 15", "protein_names_refseq": "tripartite motif-containing protein 15-like; tripartite motif-containing protein 15", "tax_id": 10116, "disease": "", "pathway": " (rno:100910806)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3ZRI0", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0044790 suppression of viral release by host;GO:0045087 innate immune response;GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction;GO:1900246 positive regulation of RIG-I signaling pathway;GO:0032481 positive regulation of type I interferon production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JTL1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYM2-1", "uniprot_id": [ { "id": "PARG_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYM2", "type": "external" } ], "mass": 109003.0, "length": 972, "protein_name": "Poly(ADP-ribose) glycohydrolase", "gene_name": "Parg", "organism": "Rat", "refseq_name": "poly(ADP-ribose) glycohydrolase", "refseq_ac": [ { "id": "NP_112629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112629", "type": "external" } ], "gene_names_uniprotkb": "Parg", "gene_names_refseq": "Parg", "protein_names_uniprotkb": "Poly(ADP-ribose) glycohydrolase; 3.2.1.143", "protein_names_refseq": "poly(ADP-ribose) glycohydrolase", "tax_id": 10116, "disease": "stress-induced childhood-onset neurodegeneration with variable ataxia and seizures (Disease Ontology:DOID:0070352); brain infarction (Disease Ontology:DOID:3454); borna disease (Disease Ontology:DOID:5154)", "pathway": " (rno:83507); (R-RNO-110362)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10502684;22609859;22673903", "class_list": "", "function": "Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress. Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond. Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters. Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming., [UniProtKB, UniProtKB]; The study reports the crystal structures of Parg and its complex with a substrate mimic that reveal an open substrate-binding site and a unique 'tyrosine clasp' enabling endoglycosidic cleavage of branched PAR chains. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0004649 poly(ADP-ribose) glycohydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0016045 detection of bacterium;GO:0006974 DNA damage response;GO:0045739 positive regulation of DNA repair;GO:0009225 nucleotide-sugar metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QYM2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M3E3-1", "uniprot_id": [ { "id": "F1M3E3_RAT", "url": "https://www.uniprot.org/uniprot/F1M3E3", "type": "external" } ], "mass": 60590.0, "length": 529, "protein_name": "UDP-glucuronosyltransferase", "gene_name": "AC114845.1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AC114845.1", "gene_names_refseq": "", "protein_names_uniprotkb": "UDP-glucuronosyltransferase; 2.4.1.17", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-156588); (R-RNO-9749641); (R-RNO-9757110)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" } ], "go_molecular_function": "GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M3E3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17256-1", "uniprot_id": [ { "id": "KIME_RAT", "url": "https://www.uniprot.org/uniprot/P17256", "type": "external" } ], "mass": 41988.0, "length": 395, "protein_name": "Mevalonate kinase", "gene_name": "Mvk", "organism": "Rat", "refseq_name": "mevalonate kinase isoform 1", "refseq_ac": [ { "id": "NP_112325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112325", "type": "external" } ], "gene_names_uniprotkb": "Mvk", "gene_names_refseq": "Lrbp; MK; Mvk", "protein_names_uniprotkb": "Mevalonate kinase; 2.7.1.36; MK", "protein_names_refseq": "LHR mRNA binding protein; mevalonate kinase isoform 1", "tax_id": 10116, "disease": "mevalonic aciduria (Disease Ontology:DOID:0050452); hyperimmunoglobulinemia D periodic fever syndrome (Disease Ontology:DOID:0081450); cancer (Disease Ontology:DOID:162); lipid metabolism disorder (Disease Ontology:DOID:3146); porokeratosis (Disease Ontology:DOID:3805)", "pathway": " (rno:81727); (R-RNO-9969896)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11877411;1312092;14680942;14730012;18302342;2158094;24064360;30735219", "class_list": "", "function": "Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results suggest that hCG-induced down-regulation of LHR mRNA expression is mediated by activation of cAMP/PKA/ERK pathways to increase miR-122 expression, which then increases LRBP expression through the activation of SREBPs., [RefSeq, PubMed]; This study demonstrated that significant conformational change on a flexible loop connecting the alpha6 and alpha7 helix is induced by the substrate mevalonate binding. Further, the study found that Asp204 is coordinated to the Mg2+ ion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.36", "type": "external" } ], "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0000287 magnesium ion binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0045540 regulation of cholesterol biosynthetic process;GO:0050728 negative regulation of inflammatory response;GO:0006695 cholesterol biosynthetic process;GO:0016125 sterol metabolic process;GO:0017148 negative regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P17256-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V9G5-1", "uniprot_id": [ { "id": "G3V9G5_RAT", "url": "https://www.uniprot.org/uniprot/G3V9G5", "type": "external" } ], "mass": 172879.0, "length": 1557, "protein_name": "Synemin", "gene_name": "Synm", "organism": "Rat", "refseq_name": "synemin", "refseq_ac": [ { "id": "NP_001128330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128330", "type": "external" } ], "gene_names_uniprotkb": "Synm", "gene_names_refseq": "Dmn; Synm", "protein_names_uniprotkb": "Synemin", "protein_names_refseq": "desmuslin; synemin, intermediate filament protein; synemin", "tax_id": 10116, "disease": "", "pathway": " (rno:308709)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21139996;21982947;22673903;35769011", "class_list": "", "function": "Retinal injury induces an upregulation of a complement of four intermediate filament proteins, including synemin and nestin, in Muller cells. Publication Status: Online-Only, [RefSeq, PubMed]; Synemin promotes pulmonary artery smooth muscle cell phenotypic switch in shunt-induced pulmonary arterial hypertension., [RefSeq, PubMed]; We conclude that beta-synemin mediates the association of desmin intermediate filaments with Z disks, whereas alpha-synemin stabilizes junctional complexes between cardiomyocytes., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, 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Also exhibits mutase (EC 5.4.2.11) activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" } ], "go_molecular_function": "GO:0004082 bisphosphoglycerate mutase activity;GO:0004619 phosphoglycerate mutase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0060856 establishment of blood-brain barrier;GO:0006096 glycolytic process;GO:0033554 cellular response to stress;GO:0048821 erythrocyte development;GO:0042832 defense response to protozoan", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P6G4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GV76-1", "uniprot_id": [ { "id": "B2GV76_RAT", "url": "https://www.uniprot.org/uniprot/B2GV76", "type": "external" } ], "mass": 28563.0, "length": 261, "protein_name": "VPS37D subunit of ESCRT-I", "gene_name": "Vps37d", "organism": "Rat", "refseq_name": "vacuolar protein sorting-associated protein 37D", "refseq_ac": [ { "id": "NP_001121665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121665", "type": "external" } ], "gene_names_uniprotkb": "Vps37d", "gene_names_refseq": "Vps37d", "protein_names_uniprotkb": "VPS37D subunit of ESCRT-I", "protein_names_refseq": "VPS37D, ESCRT-I subunit; vacuolar protein sorting 37 homolog D; vacuolar protein sorting 37D; vacuolar protein sorting-associated protein 37D", "tax_id": 10116, "disease": "", "pathway": " (rno:687208); (R-RNO-917729)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031902 late endosome membrane;GO:0000813 ESCRT I complex", "go_biological_process": "GO:0015031 protein transport;GO:0006612 protein targeting to membrane;GO:0006623 protein targeting to vacuole;GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2GV76-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LW16-1", "uniprot_id": [ { "id": "F1LW16_RAT", "url": "https://www.uniprot.org/uniprot/F1LW16", "type": "external" } ], "mass": 207722.0, "length": 1855, "protein_name": "B-TFIID TATA-box binding protein associated factor 1", "gene_name": "Btaf1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Btaf1", "gene_names_refseq": "", "protein_names_uniprotkb": "B-TFIID TATA-box binding protein associated factor 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:368042)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16641100", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0017025 TBP-class protein binding;GO:0004386 helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1LW16-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z9R7-1", "uniprot_id": [ { "id": "D3Z9R7_RAT", "url": "https://www.uniprot.org/uniprot/D3Z9R7", "type": "external" } ], "mass": 37161.0, "length": 326, "protein_name": "Syntaxin-16", "gene_name": "Stx16", "organism": "Rat", "refseq_name": "syntaxin-16 isoform 1", "refseq_ac": [ { "id": "NP_001388822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388822", "type": "external" } ], "gene_names_uniprotkb": "Stx16", "gene_names_refseq": "Stx16", "protein_names_uniprotkb": "Syntaxin-16", "protein_names_refseq": "syntaxin-16 isoform 1", "tax_id": 10116, "disease": "pseudohypoparathyroidism type 1B (Disease Ontology:DOID:0080222)", "pathway": " (rno:362283); (R-RNO-6811438); (R-RNO-6811440)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity;GO:0019905 syntaxin binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0012505 endomembrane system;GO:0031201 SNARE complex;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006906 vesicle fusion;GO:0048278 vesicle docking;GO:0042147 retrograde transport, endosome to Golgi;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3Z9R7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZBQ6-1", "uniprot_id": [ { "id": "D3ZBQ6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZBQ6", "type": "external" } ], "mass": 35202.0, "length": 323, "protein_name": "carbonic anhydrase", "gene_name": "Car15", "organism": "Rat", "refseq_name": "carbonic anhydrase 15 precursor", "refseq_ac": [ { "id": "NP_001099371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099371", "type": "external" } ], "gene_names_uniprotkb": "Car15", "gene_names_refseq": "Ca15; 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Car6", "gene_names_refseq": "Ca6; Car6", "protein_names_uniprotkb": "Carbonic anhydrase; 4.2.1.1", "protein_names_refseq": "carbonic anhydrase 6 isoform 1 precursor; carbonic anhydrase VI; gustin", "tax_id": 10116, "disease": "", "pathway": " (rno:298657); (R-RNO-1475029)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Reversible hydration of carbon dioxide. Its role in saliva is unknown., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LQ08-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LQ30-1", "uniprot_id": [ { "id": "F1LQ30_RAT", "url": "https://www.uniprot.org/uniprot/F1LQ30", "type": "external" } ], "mass": 42618.0, "length": 407, "protein_name": "Homeobox even-skipped homolog protein 1", "gene_name": "Evx1", "organism": "Rat", "refseq_name": "homeobox even-skipped homolog protein 1", "refseq_ac": [ { "id": "NP_001178901", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178901", "type": "external" } ], "gene_names_uniprotkb": "Evx1; NEWGENE_1565788", "gene_names_refseq": "Evx1; RGD1565788", "protein_names_uniprotkb": "Homeobox even-skipped homolog protein 1; EVX-1", "protein_names_refseq": "even skipped homeotic gene 1 homolog; homeobox even-skipped homolog protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:103690342)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0030424 axon;GO:0044297 cell body", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0097377 spinal cord interneuron axon guidance;GO:1904936 interneuron migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LQ30-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LQT1-1", "uniprot_id": [ { "id": "F1LQT1_RAT", "url": "https://www.uniprot.org/uniprot/F1LQT1", "type": "external" } ], "mass": 122941.0, "length": 1100, "protein_name": "Adenylate cyclase type 7", "gene_name": "Adcy7", "organism": "Rat", "refseq_name": "adenylate cyclase type 7", "refseq_ac": [ { "id": "NP_445848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445848", "type": "external" } ], "gene_names_uniprotkb": "Adcy7", "gene_names_refseq": "Adcy7", "protein_names_uniprotkb": "Adenylate cyclase type 7; 4.6.1.1", "protein_names_refseq": "adenylate cyclase type 7; adenylyl cyclase 7", "tax_id": 10116, "disease": "", "pathway": " (rno:84420); (R-RNO-163615); (R-RNO-170660); (R-RNO-170670); (R-RNO-418597); (R-RNO-5610787)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "34177802", "class_list": "", "function": "Adenylate cyclase that mediates formation of both cyclic AMP (cAMP) and cyclic di-AMP (c-di-AMP). Acts as a key mediator of G protein-coupled receptor signaling by catalyzing the formation of cAMP downstream of G protein-coupled receptors. Functions in G protein-coupled receptor signaling cascades activated by thrombin, sphingosine 1-phosphate, dopamine and anaphylatoxin C5a. Mediates regulation of cAMP synthesis through synergistic action of the G alpha protein G(s) (GNAS) with G(13) (GNA13). Also involved in inflammation by acting as a diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into c-di-AMP. Following activation by TLR9, mediates formation of c-di-AMP, which directly activates NLRP3, thereby promoting assembly and maturation of the NLRP3 inflammasome. It is also required for the optimal functions of B- and T cells during adaptive immune responses by regulating cAMP synthesis in both B- and T-cells., [UniProtKB, UniProtKB]; CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin Secretion Pathway Leading to Excessive Insulin Secretion. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0031683 G-protein beta/gamma-subunit complex binding;GO:0106408 diadenylate cyclase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0060135 maternal process involved in female pregnancy;GO:0071361 cellular response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1LQT1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LR76-1", "uniprot_id": [ { "id": "F1LR76_RAT", "url": "https://www.uniprot.org/uniprot/F1LR76", "type": "external" } ], "mass": 54499.0, "length": 486, "protein_name": "Hexosaminidase D", "gene_name": "Hexd", "organism": "Rat", "refseq_name": "hexosaminidase D", "refseq_ac": [ { "id": "NP_001136034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136034", "type": "external" } ], "gene_names_uniprotkb": "Hexd; Hexdc", "gene_names_refseq": "Hexdc; Hexd", "protein_names_uniprotkb": "Hexosaminidase D; 3.2.1.52; Beta-N-acetylhexosaminidase; Beta-hexosaminidase D; Hexosaminidase domain-containing protein; N-acetyl-beta-galactosaminidase", "protein_names_refseq": "hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing; hexosaminidase D, catalytic domain containing; hexosaminidase D", "tax_id": 10116, "disease": "", "pathway": " (rno:100216475)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015929 hexosaminidase activity;GO:0004563 beta-N-acetylhexosaminidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1903561 extracellular vesicle", "go_biological_process": "GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1LR76-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LR98-1", "uniprot_id": [ { "id": "F1LR98_RAT", "url": "https://www.uniprot.org/uniprot/F1LR98", "type": "external" } ], "mass": 88015.0, "length": 786, "protein_name": "Cadherin-10", "gene_name": "Cdh10", "organism": "Rat", "refseq_name": "cadherin-10 isoform X2", "refseq_ac": [ { "id": "XP_006232142", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006232142", "type": "external" } ], "gene_names_uniprotkb": "Cdh10", "gene_names_refseq": "Cdh10", "protein_names_uniprotkb": "Cadherin-10; T2-cadherin", "protein_names_refseq": "cadherin-10 isoform X2", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:29181); (R-RNO-418990)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005912 adherens junction;GO:0045202 synapse", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0098609 cell-cell adhesion;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1LR98-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LRI5-1", "uniprot_id": [ { "id": "F1LRI5_RAT", "url": "https://www.uniprot.org/uniprot/F1LRI5", "type": "external" } ], "mass": 293072.0, "length": 2671, "protein_name": "Stalled ribosome sensor GCN1", "gene_name": "Gcn1", "organism": "Rat", "refseq_name": "stalled ribosome sensor GCN1", "refseq_ac": [ { "id": "NP_001162135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162135", "type": "external" } ], "gene_names_uniprotkb": "Gcn1; Gcn1l1", "gene_names_refseq": "Gcn1l1; Gcn1", "protein_names_uniprotkb": "Stalled ribosome sensor GCN1; GCN1 eIF-2-alpha kinase activator homolog; GCN1-like protein 1; General control of amino-acid synthesis 1-like protein 1; Translational activator GCN1", "protein_names_refseq": "GCN1 eIF2 alpha kinase activator-like 1; GCN1 general control of amino-acid synthesis 1-like 1; GCN1, eIF2 alpha kinase activator homolog; eIF-2-alpha kinase activator GCN1; stalled ribosome sensor GCN1; translational activator GCN1", "tax_id": 10116, "disease": "", "pathway": " (rno:690632)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019887 protein kinase regulator activity;GO:0043539 protein serine/threonine kinase activator activity;GO:0170011 stalled ribosome sensor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0006417 regulation of translation;GO:0034198 cellular response to amino acid starvation;GO:0140469 GCN2-mediated signaling;GO:0160127 protein-RNA covalent cross-linking repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LRI5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LRZ0-1", "uniprot_id": [ { "id": "F1LRZ0_RAT", "url": "https://www.uniprot.org/uniprot/F1LRZ0", "type": "external" } ], "mass": 174816.0, "length": 1617, "protein_name": "Tyrosine-protein kinase receptor", "gene_name": "Alk", "organism": "Rat", "refseq_name": "ALK tyrosine kinase receptor precursor", "refseq_ac": [ { "id": "NP_001162572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162572", "type": "external" } ], "gene_names_uniprotkb": "Alk", "gene_names_refseq": "Alk", "protein_names_uniprotkb": "Tyrosine-protein kinase receptor; 2.7.10.1", "protein_names_refseq": "ALK tyrosine kinase receptor precursor; ALK tyrosine kinase receptor-like; ALK tyrosine kinase receptor; anaplastic lymphoma kinase; anaplastic lymphoma receptor tyrosine kinase", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); cancer (Disease Ontology:DOID:162); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (rno:266802); (R-RNO-201556); (R-RNO-9851151)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15886198;16880530;25326243", "class_list": "", "function": "ALK has a proapoptotic activity in the absence of ligand, whereas it is antiapoptotic in the presence of its ligand and when the kinase is intrinsically activated., [RefSeq, PubMed]; Analysis of differentiation of PC12 cells and human embryonic kidney 293 cells transfected with ALK shows absence of agonist activity of pleiotrophin, [RefSeq, PubMed]; Electroretinography b-wave amplitude decreases during dark adaption following crizotinib administration may be related to signaling changes within the retina in rats, likely independent of ALK inhibition., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0030298 receptor signaling protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0030534 adult behavior;GO:0038083 peptidyl-tyrosine autophosphorylation;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1LRZ0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LSH5-1", "uniprot_id": [ { "id": "F1LSH5_RAT", "url": "https://www.uniprot.org/uniprot/F1LSH5", "type": "external" } ], "mass": 53723.0, "length": 466, "protein_name": "Zinc finger protein 791", "gene_name": "Zfp867", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zfp867", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 791", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-212436); (R-RNO-9843940)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LSH5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LT33-1", "uniprot_id": [ { "id": "F1LT33_RAT", "url": "https://www.uniprot.org/uniprot/F1LT33", "type": "external" } ], "mass": 56270.0, "length": 495, "protein_name": "Cytochrome P450", "gene_name": "Cyp2b14", "organism": "Rat", "refseq_name": "cytochrome P450 2B15", "refseq_ac": [ { "id": "XP_008757425", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008757425", "type": "external" } ], "gene_names_uniprotkb": "Cyp2b14; LOC103691072", "gene_names_refseq": "Cyp2b14", "protein_names_uniprotkb": "Cytochrome P450; 1.14.14.1", "protein_names_refseq": "cytochrome P450 2B15", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); tuberculosis (Disease Ontology:DOID:399); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acute myeloid leukemia (Disease Ontology:DOID:9119); neonatal abstinence syndrome (Disease Ontology:DOID:9828); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:103691072)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LT33-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LT39-1", "uniprot_id": [ { "id": "F1LT39_RAT", "url": "https://www.uniprot.org/uniprot/F1LT39", "type": "external" } ], "mass": 37028.0, "length": 326, "protein_name": "Acyltransferase", "gene_name": "Mogat3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mogat3; LOC685560", "gene_names_refseq": "", "protein_names_uniprotkb": "Acyltransferase; 2.3.1.-", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:685560)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004144 diacylglycerol O-acyltransferase activity;GO:0003846 2-acylglycerol O-acyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:1990578 perinuclear endoplasmic reticulum membrane", "go_biological_process": "GO:0019432 triglyceride biosynthetic process;GO:0006640 monoacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LT39-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LT57-1", "uniprot_id": [ { "id": "F1LT57_RAT", "url": "https://www.uniprot.org/uniprot/F1LT57", "type": "external" } ], "mass": 24828.0, "length": 224, "protein_name": "Similar to human chromosome 1 open reading frame 185", "gene_name": "C5h1orf185", "organism": "Rat", "refseq_name": "uncharacterized protein C1orf185 homolog isoform X5", "refseq_ac": [ { "id": "XP_063144512", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063144512", "type": "external" } ], "gene_names_uniprotkb": "C5h1orf185; 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RGD1559459", "gene_names_refseq": "Ugt2b34l1", "protein_names_uniprotkb": "UDP-glucuronosyltransferase; 2.4.1.17", "protein_names_refseq": "UDP-glucuronosyltransferase 2B31-like isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:501907); (R-RNO-156588); (R-RNO-9749641); (R-RNO-9757110)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" } ], "go_molecular_function": "GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LTB8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LTN0-1", "uniprot_id": [ { "id": "F1LTN0_RAT", "url": "https://www.uniprot.org/uniprot/F1LTN0", "type": "external" } ], "mass": 22548.0, "length": 203, "protein_name": "Interleukin-17C", "gene_name": "Il17c", "organism": "Rat", "refseq_name": "interleukin-17C precursor", "refseq_ac": [ { "id": "NP_001178044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178044", "type": "external" } ], "gene_names_uniprotkb": "Il17c", "gene_names_refseq": "Il17c", "protein_names_uniprotkb": "Interleukin-17C; Cytokine CX2", "protein_names_refseq": "interleukin-17C precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:691516)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030223 neutrophil differentiation;GO:0006954 inflammatory response;GO:1900017 positive regulation of cytokine production involved in inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LTN0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LTT8-1", "uniprot_id": [ { "id": "F1LTT8_RAT", "url": "https://www.uniprot.org/uniprot/F1LTT8", "type": "external" } ], "mass": 37156.0, "length": 340, "protein_name": "C2 calcium-dependent domain containing 4A", "gene_name": "C2cd4a", "organism": "Rat", "refseq_name": "C2 calcium-dependent domain-containing protein 4A", "refseq_ac": [ { "id": "NP_001385946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385946", "type": "external" } ], "gene_names_uniprotkb": "C2cd4a", "gene_names_refseq": "C2cd4a; Fam148a; Nlf1", "protein_names_uniprotkb": "C2 calcium-dependent domain containing 4A", "protein_names_refseq": "C2 calcium-dependent domain-containing protein 4A; family with sequence similarity 148, member A; nuclear localized factor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:691703)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0030155 regulation of cell adhesion;GO:0002675 positive regulation of acute inflammatory response;GO:0002528 regulation of vascular permeability involved in acute inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LTT8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LTX5-1", "uniprot_id": [ { "id": "F1LTX5_RAT", "url": "https://www.uniprot.org/uniprot/F1LTX5", "type": "external" } ], "mass": 20812.0, "length": 182, "protein_name": "Ferritin", "gene_name": "Fthl17a", "organism": "Rat", "refseq_name": "ferritin, heavy polypeptide-like 17, member E", "refseq_ac": [ { "id": "NP_001395802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001395802", "type": "external" } ], "gene_names_uniprotkb": "Fthl17a; 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Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008198 ferrous iron binding;GO:0008199 ferric iron binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LTX5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LU69-1", "uniprot_id": [ { "id": "F1LU69_RAT", "url": "https://www.uniprot.org/uniprot/F1LU69", "type": "external" } ], "mass": 17103.0, "length": 150, "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "Rps27a-ps28", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rps27a-ps28; Rps27a-ps12; Ubbp4", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin-ribosomal protein eS31 fusion protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the 40S subunit of the ribosome. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0022626 cytosolic ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006412 translation;GO:0019941 modification-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LU69-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LU95-1", "uniprot_id": [ { "id": "F1LU95_RAT", "url": "https://www.uniprot.org/uniprot/F1LU95", "type": "external" } ], "mass": 43680.0, "length": 383, "protein_name": "Zinc finger protein 866", "gene_name": "Zfp866", "organism": "Rat", "refseq_name": "zinc finger protein 866", "refseq_ac": [ { "id": "NP_001395692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001395692", "type": "external" } ], "gene_names_uniprotkb": "Zfp866", "gene_names_refseq": "Zfp866", "protein_names_uniprotkb": "Zinc finger protein 866", "protein_names_refseq": "zinc finger protein 20; zinc finger protein 709; zinc finger protein 791; zinc finger protein 866; zinc finger-like protein-like", "tax_id": 10116, "disease": "", "pathway": " (rno:100362083); (R-RNO-212436)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LU95-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LUC6-1", "uniprot_id": [ { "id": "F1LUC6_RAT", "url": "https://www.uniprot.org/uniprot/F1LUC6", "type": "external" } ], "mass": 34724.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or5p5b", "organism": "Rat", "refseq_name": "olfactory receptor Olr235", "refseq_ac": [ { "id": "NP_001000209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000209", "type": "external" } ], "gene_names_uniprotkb": "Or5p5b", "gene_names_refseq": "Olr235; Or5p5b", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 235; olfactory receptor Olr235; olfactory receptor gene Olr235", "tax_id": 10116, "disease": "", "pathway": " (rno:293381)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LUC6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LUF8-1", "uniprot_id": [ { "id": "F1LUF8_RAT", "url": "https://www.uniprot.org/uniprot/F1LUF8", "type": "external" } ], "mass": 109838.0, "length": 990, "protein_name": "Zinc finger protein basonuclin-1", "gene_name": "Bnc1", "organism": "Rat", "refseq_name": "zinc finger protein basonuclin-1", "refseq_ac": [ { "id": "NP_001102386", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102386", "type": "external" } ], "gene_names_uniprotkb": "Bnc1", "gene_names_refseq": "Bnc1", "protein_names_uniprotkb": "Zinc finger protein basonuclin-1", "protein_names_refseq": "basonuclin 1; zinc finger protein basonuclin-1", "tax_id": 10116, "disease": "primary ovarian insufficiency 16 (Disease Ontology:DOID:0080873)", "pathway": " (rno:365299)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional activator. It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles. Required for the maintenance of spermatogenesis. It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade. May also play a role in the early development of embryos., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000182 rDNA binding;GO:0001216 DNA-binding transcription activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0042060 wound healing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LUF8-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LUK0-1", "uniprot_id": [ { "id": "F1LUK0_RAT", "url": 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"", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); amphetamine abuse (Disease Ontology:DOID:670)", "pathway": " (rno:501558)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, 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"external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004709 MAP kinase kinase kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0007254 JNK cascade;GO:0038066 p38MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LUY7-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LV01-1", "uniprot_id": [ { "id": "F1LV01_RAT", "url": "https://www.uniprot.org/uniprot/F1LV01", "type": "external" } ], "mass": 151476.0, "length": 1341, "protein_name": "WD repeat-containing protein 19", "gene_name": "Wdr19", "organism": "Rat", "refseq_name": "WD repeat-containing protein 19", "refseq_ac": [ { "id": "NP_001178608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178608", "type": "external" } ], "gene_names_uniprotkb": "Wdr19", "gene_names_refseq": "RGD1306997; Wdr19", "protein_names_uniprotkb": "WD repeat-containing protein 19; Intraflagellar transport 144 homolog", "protein_names_refseq": "WD repeat-containing protein 19", "tax_id": 10116, "disease": "Senior-Loken syndrome (Disease Ontology:DOID:0050576); Caroli disease (Disease Ontology:DOID:0050876); ciliopathy (Disease Ontology:DOID:0060340); spermatogenic failure 72 (Disease Ontology:DOID:0070571); cranioectodermal dysplasia 4 (Disease Ontology:DOID:0080806); asphyxiating thoracic dystrophy 5 (Disease Ontology:DOID:0110089); nephronophthisis 13 (Disease Ontology:DOID:0111121); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (rno:305349); (R-RNO-5610787); (R-RNO-5620924)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in cilia function and/or assembly. Essential for functional IFT-A assembly and ciliary entry of GPCRs. 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Smco1", "protein_names_uniprotkb": "Single-pass membrane protein with coiled-coil domains 1", "protein_names_refseq": "single-pass membrane and coiled-coil domain-containing protein 1; single-pass membrane protein with coiled-coil domains 1 isoform a", "tax_id": 10116, "disease": "", "pathway": " (rno:498096)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "28932249", "class_list": "", "function": "SMCO1 may contribute to hepatocyte proliferation and may have the potential to promote liver repair and regeneration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1LVE5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LVG2-1", "uniprot_id": [ { "id": "F1LVG2_RAT", "url": "https://www.uniprot.org/uniprot/F1LVG2", "type": "external" } ], "mass": 24634.0, "length": 216, "protein_name": "Similar to human chromosome 3 open reading frame 52", "gene_name": "C11h3orf52", "organism": "Rat", "refseq_name": "similar to human chromosome 3 open reading frame 52", "refseq_ac": [ { "id": "NP_001413967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001413967", "type": "external" } ], "gene_names_uniprotkb": "C11h3orf52; 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inflammatory bowel disease 17 (Disease Ontology:DOID:0110883); psoriasis 7 (Disease Ontology:DOID:0111279); osteonecrosis (Disease Ontology:DOID:10159); celiac disease (Disease Ontology:DOID:10608); sarcoidosis (Disease Ontology:DOID:11335); Graves' disease (Disease Ontology:DOID:12361); Sjogren's syndrome (Disease Ontology:DOID:12894); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); multiple sclerosis (Disease Ontology:DOID:2377); pulmonary tuberculosis (Disease Ontology:DOID:2957); systemic scleroderma (Disease Ontology:DOID:418); rhinitis (Disease Ontology:DOID:4483); pulmonary hypertension (Disease Ontology:DOID:6432); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); arthritis (Disease Ontology:DOID:848); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (R-RNO-9020933)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25600958;33843019", "class_list": "", "function": "Associates with IL12RB1 to form the interleukin-23 receptor. 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Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005929 cilium;GO:0055037 recycling endosome;GO:0060170 ciliary membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M5Q2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M5Q6-1", "uniprot_id": [ { "id": "F1M5Q6_RAT", "url": "https://www.uniprot.org/uniprot/F1M5Q6", "type": "external" } ], "mass": 72123.0, "length": 627, "protein_name": "F-box protein 21", "gene_name": "Fbxo21", "organism": "Rat", "refseq_name": "F-box only protein 21 isoform X1", "refseq_ac": [ { "id": "XP_038945529", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038945529", "type": "external" } ], "gene_names_uniprotkb": "Fbxo21", "gene_names_refseq": "Fbxo21", "protein_names_uniprotkb": "F-box protein 21", "protein_names_refseq": "F-box only protein 21 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "", "go_biological_process": "GO:0006915 apoptotic process;GO:0060218 hematopoietic stem cell differentiation;GO:0070371 ERK1 and ERK2 cascade;GO:0019221 cytokine-mediated signaling pathway;GO:0061484 hematopoietic stem cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M5Q6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M629-1", "uniprot_id": [ { "id": "F1M629_RAT", "url": "https://www.uniprot.org/uniprot/F1M629", "type": "external" } ], "mass": 14290.0, "length": 129, "protein_name": "Gem-associated protein 7", "gene_name": "Gemin7l1", "organism": "Rat", "refseq_name": "gem (nuclear organelle) associated protein 7-like 1", "refseq_ac": [ { "id": "NP_001395727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001395727", "type": "external" } ], "gene_names_uniprotkb": "Gemin7l1; Gemin7", "gene_names_refseq": "Gemin7l1; Gemin7", "protein_names_uniprotkb": "Gem-associated protein 7", "protein_names_refseq": "gem (nuclear organelle) associated protein 7-like 1; gem (nuclear organelle) associated protein 7; gem-associated protein 7; rCG54304-like", "tax_id": 10116, "disease": "", "pathway": " (rno:685068); (R-RNO-191859)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0034719 SMN-Sm protein complex;GO:0097504 Gemini of Cajal bodies;GO:0120114 Sm-like protein family complex", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M629-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M6A9-1", "uniprot_id": [ { "id": "F1M6A9_RAT", "url": "https://www.uniprot.org/uniprot/F1M6A9", "type": "external" } ], "mass": 58242.0, "length": 529, "protein_name": "Ceramide kinase-like", "gene_name": "Cerkl", "organism": "Rat", "refseq_name": "ceramide kinase-like protein isoform X1", "refseq_ac": [ { "id": "XP_056841364", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_056841364", "type": "external" } ], "gene_names_uniprotkb": "Cerkl", "gene_names_refseq": "Cerkl", "protein_names_uniprotkb": "Ceramide kinase-like", "protein_names_refseq": "ceramide kinase-like protein isoform X1", "tax_id": 10116, "disease": "retinitis pigmentosa 26 (Disease Ontology:DOID:0110368); 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As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway., [UniProtKB, UniProtKB]; Enhances expression of insulin, and promotes transdifferentiation of bone marrow mesenchymal stem cells into islet-like cells, [RefSeq, PubMed]; LAMC1 attenuates neuronal apoptosis via FAK/PI3K/AKT signaling pathway after subarachnoid hemorrhage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043208 glycosphingolipid binding;GO:0048018 receptor ligand activity;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0031594 neuromuscular junction;GO:0043083 synaptic cleft;GO:0005604 basement membrane;GO:0005606 laminin-1 complex", "go_biological_process": "GO:0048729 tissue morphogenesis;GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0022617 extracellular matrix disassembly", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "F1MAA7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MAB2-1", "uniprot_id": [ { "id": "F1MAB2_RAT", "url": "https://www.uniprot.org/uniprot/F1MAB2", "type": "external" } ], "mass": 110156.0, "length": 1004, "protein_name": "Endosome/lysosome-associated apoptosis and autophagy regulator 1", "gene_name": "Elapor1", "organism": "Rat", "refseq_name": "endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001414761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414761", "type": "external" } ], "gene_names_uniprotkb": "Elapor1", "gene_names_refseq": "Elapor1; RGD1310209", "protein_names_uniprotkb": "Endosome/lysosome-associated apoptosis and autophagy regulator 1", "protein_names_refseq": "endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 2 precursor", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May protect cells from cell death by inducing cytosolic vacuolization and up-regulating the autophagy pathway. May play a role in apoptosis and cell proliferation through its interaction with HSPA5., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005770 late endosome;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0044090 positive regulation of vacuole organization;GO:0009267 cellular response to starvation;GO:2000786 positive regulation of autophagosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MAB2-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MAC3-1", "uniprot_id": [ { "id": "F1MAC3_RAT", "url": "https://www.uniprot.org/uniprot/F1MAC3", "type": "external" } ], "mass": 24717.0, "length": 221, "protein_name": "CD79a molecule", "gene_name": "Cd79a", "organism": "Rat", "refseq_name": "B-cell antigen receptor complex-associated protein alpha chain precursor", "refseq_ac": [ { "id": "NP_001389476", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001389476", "type": "external" } ], "gene_names_uniprotkb": "Cd79a", "gene_names_refseq": "Cd79al; Cd79a", "protein_names_uniprotkb": "CD79a molecule", "protein_names_refseq": "-cell antigen receptor complex-associated protein alpha chain-like; B-cell antigen receptor complex-associated protein alpha chain precursor; B-cell antigen receptor complex-associated protein alpha chain-like; CD79A antigen (immunoglobulin-associated alpha); Cd79a molecule, immunoglobulin-associated alpha; Cd79a molecule-like", "tax_id": 10116, "disease": "agammaglobulinemia 3 (Disease Ontology:DOID:0081137)", "pathway": " (rno:100913063); (R-RNO-5690714); (R-RNO-983695)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane;GO:0005771 multivesicular body;GO:0019815 B cell receptor complex", "go_biological_process": "GO:0042113 B cell activation;GO:0050853 B cell receptor signaling pathway;GO:0030183 B cell differentiation;GO:0042100 B cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MAC3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MAE5-1", "uniprot_id": [ { "id": "F1MAE5_RAT", "url": "https://www.uniprot.org/uniprot/F1MAE5", "type": "external" } ], "mass": 765797.0, "length": 6882, "protein_name": "Proline rich protein 2-like 1", "gene_name": "Prp2l1", "organism": "Rat", "refseq_name": "proline rich protein 2-like 1 precursor", "refseq_ac": [ { "id": "NP_001406836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001406836", "type": "external" } ], "gene_names_uniprotkb": "Prp2l1", "gene_names_refseq": "PRP-2; PRP; Prp-5; Prp2l1; Prp2l2", "protein_names_uniprotkb": "Proline rich protein 2-like 1", "protein_names_refseq": "proline rich protein 2-like 1 precursor; proline rich protein 2-like 2; proline-rich protein", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 38, "predicted_n_glycosites": 0, "predicted_o_glycosites": 38, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 38, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MAE5-1", "record_type": "protein", "filter_code": "0000000.0000100.000010.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MAH6-1", "uniprot_id": [ { "id": "F1MAH6_RAT", "url": "https://www.uniprot.org/uniprot/F1MAH6", "type": "external" } ], "mass": 88036.0, "length": 796, "protein_name": "Cadherin 11", "gene_name": "Cdh11", "organism": "Rat", "refseq_name": "cadherin-11 precursor", "refseq_ac": [ { "id": "NP_445844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445844", "type": "external" } ], "gene_names_uniprotkb": "Cdh11", "gene_names_refseq": "Cdh11", "protein_names_uniprotkb": "Cadherin 11", "protein_names_refseq": "cadherin-11 precursor", "tax_id": 10116, "disease": "Elsahy-Waters syndrome (Disease Ontology:DOID:0080631); Teebi hypertelorism syndrome 2 (Disease Ontology:DOID:0081074); prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:84407); (R-RNO-418990); (R-RNO-9762292); (R-RNO-9958825)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "21250828;22673903;23916685;24090084;24139451;25681337", "class_list": "", "function": "Cadherin-11 expression is relatively low in early hippocampus, but high in mature synapses, at postnatal and adult stages. Cadherin-11 might be more important for stabilization of synapses in the postnatal period and adulthood., [RefSeq, PubMed]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB, UniProtKB]; Data indicate that estradiol mainly promoted cadherin-11 expression in M1-like macrophages of inflamed temporomandibular joint., [RefSeq, PubMed]; Higher Cadherin-11 expression was observed only in the high choleserol diet-treated rats with bladder outlet obstruction. Publication Status: Online-Only, [RefSeq, PubMed]; The findings suggest that cadherin-11 may play an important role in synovial fibroblasts from the temporomandibular joint following exposure to mechanical loading and inflammatory stimulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 188, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0045202 synapse", "go_biological_process": "GO:0016477 cell migration;GO:0030336 negative regulation of cell migration;GO:0000902 cell morphogenesis;GO:0098609 cell-cell adhesion;GO:0048041 focal adhesion assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "F1MAH6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7EX58-1", "uniprot_id": [ { "id": "F7EX58_RAT", "url": "https://www.uniprot.org/uniprot/F7EX58", "type": "external" } ], "mass": 131303.0, "length": 1178, "protein_name": "PDZ and pleckstrin homology domains 1", "gene_name": "Pdzph1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pdzph1; RGD1560925", "gene_names_refseq": "", "protein_names_uniprotkb": "PDZ and pleckstrin homology domains 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7EX58-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true } ]