[ { "uniprot_canonical_ac": "M0RE14-1", "uniprot_id": [ { "id": "M0RE14_RAT", "url": "https://www.uniprot.org/uniprot/M0RE14", "type": "external" } ], "mass": 55493.0, "length": 523, "protein_name": "Chromobox 2", "gene_name": "Cbx2", "organism": "Rat", "refseq_name": "chromobox protein homolog 2", "refseq_ac": [ { "id": "NP_001100541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100541", "type": "external" } ], "gene_names_uniprotkb": "Cbx2", "gene_names_refseq": "Cbx2", "protein_names_uniprotkb": "Chromobox 2", "protein_names_refseq": "chromobox homolog 2 (Pc class homolog, Drosophila); chromobox protein homolog 2", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); 46,XY sex reversal 5 (Disease Ontology:DOID:0111776); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:303730); (R-RNO-2559580); (R-RNO-3108214); (R-RNO-3899300); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-8939243); (R-RNO-8943724)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0062072 histone H3K9me2/3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000791 euchromatin;GO:0000792 heterochromatin;GO:0031519 PcG protein complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045137 development of primary sexual characteristics", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RE14-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35531-1", "uniprot_id": [ { "id": "O35531_RAT", "url": "https://www.uniprot.org/uniprot/O35531", "type": "external" } ], "mass": 35574.0, "length": 313, "protein_name": "T-lymphocyte activation antigen CD86", "gene_name": "Cd86", "organism": "Rat", "refseq_name": "T-lymphocyte activation antigen CD86 precursor", "refseq_ac": [ { "id": "NP_064466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064466", "type": "external" } ], "gene_names_uniprotkb": "Cd86", "gene_names_refseq": "B7-2; Cd86", "protein_names_uniprotkb": "T-lymphocyte activation antigen CD86; Activation B7-2 antigen", "protein_names_refseq": "T-lymphocyte activation antigen CD86 precursor; T-lymphocyte activation antigen CD86; cd86 antigen; membrane glycoprotein", "tax_id": 10116, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); corneal disease (Disease Ontology:DOID:10124); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); IgA vasculitis (Disease Ontology:DOID:11123); aplastic anemia (Disease Ontology:DOID:12449); Guillain-Barre syndrome (Disease Ontology:DOID:12842); multiple sclerosis (Disease Ontology:DOID:2377); orchitis (Disease Ontology:DOID:2518); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); cryoglobulinemia (Disease Ontology:DOID:2917); pulmonary tuberculosis (Disease Ontology:DOID:2957); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); middle cerebral artery infarction (Disease Ontology:DOID:3525); systemic scleroderma (Disease Ontology:DOID:418); pulmonary hypertension (Disease Ontology:DOID:6432); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:56822); (R-RNO-1257604); (R-RNO-389356); (R-RNO-389357); (R-RNO-389359); (R-RNO-389513); (R-RNO-6811558)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "22673903;32733939", "class_list": "", "function": "Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation. Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation. Also acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor, thereby blocking CD28-mediated T-cell priming., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Diabetes-Mediated Toxicity Resulted in the Expression of CD80 and CD86 on Neutrophils after Delayed Wound Healing in Male Rats. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2JXF7;F1LNG0", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0070062 extracellular exosome;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0001878 response to yeast;GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0032496 response to lipopolysaccharide;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35531-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88205-1", "uniprot_id": [ { "id": "O88205_RAT", "url": "https://www.uniprot.org/uniprot/O88205", "type": "external" } ], "mass": 27344.0, "length": 243, "protein_name": "Cysteine-rich secretory protein 2", "gene_name": "Crisp2", "organism": "Rat", "refseq_name": "cysteine-rich secretory protein 2 precursor", "refseq_ac": [ { "id": "NP_001011710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011710", "type": "external" } ], "gene_names_uniprotkb": "Crisp2", "gene_names_refseq": "Crisp2l; Crisp2; Tpx1", "protein_names_uniprotkb": "Cysteine-rich secretory protein 2", "protein_names_refseq": "cysteine-rich secretory protein 2 precursor; testis specific protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:360445); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6JJ62", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007283 spermatogenesis;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O88205-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89035-1", "uniprot_id": [ { "id": "DIC_RAT", "url": "https://www.uniprot.org/uniprot/O89035", "type": "external" } ], "mass": 31455.0, "length": 286, "protein_name": "Mitochondrial dicarboxylate carrier", "gene_name": "Slc25a10", "organism": "Rat", "refseq_name": "mitochondrial dicarboxylate carrier", "refseq_ac": [ { "id": "NP_596909", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596909", "type": "external" } ], "gene_names_uniprotkb": "Slc25a10", "gene_names_refseq": "Dic; Slc25a10", "protein_names_uniprotkb": "Mitochondrial dicarboxylate carrier; DIC; Solute carrier family 25 member 10", "protein_names_refseq": "dicarboxylate transporter), member 10; mitochondrial dicarboxylate carrier; solute carrier family 25 (mitochondrial carrier", "tax_id": 10116, "disease": "myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); mitochondrial DNA depletion syndrome (Disease Ontology:DOID:0070329); mitochondrial DNA depletion syndrome 19 (Disease Ontology:DOID:0070450)", "pathway": " (rno:170943); (R-RNO-1614517); (R-RNO-428643)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "20538765;20949348;29211846;3355813;8985166;9733776", "class_list": "", "function": "Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across the mitochondrial inner membrane (PubMed:29211846, PubMed:3355813, PubMed:9733776). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (By similarity). Does not transport glutathione (By similarity). Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes (PubMed:9733776). Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Dicarboxylate carrier-mediated glutathione transport is essential for brain mitochondria to maintain reactive oxygen species homeostasis and normal respiratory functions., [RefSeq, PubMed]; The studies also suggest that malate transport by DIC is (1) a critical component of NADPH production mediated by pyruvate-cycling and (2) regulates GSIS., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0005315 phosphate transmembrane transporter activity;GO:0015291 secondary active transmembrane transporter activity;GO:0005310 dicarboxylic acid transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0006817 phosphate ion transport;GO:1902358 sulfate transmembrane transport;GO:0015709 thiosulfate transport;GO:0015729 oxaloacetate transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O89035-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06C60-1", "uniprot_id": [ { "id": "Q06C60_RAT", "url": "https://www.uniprot.org/uniprot/Q06C60", "type": "external" } ], "mass": 14403.0, "length": 137, "protein_name": "BolA-like protein 1", "gene_name": "Bola1", "organism": "Rat", "refseq_name": "bolA-like protein 1", "refseq_ac": [ { "id": "NP_001065244", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001065244", "type": "external" } ], "gene_names_uniprotkb": "Bola1", "gene_names_refseq": "Bola1; RGD1310586", "protein_names_uniprotkb": "BolA-like protein 1", "protein_names_refseq": "bolA homolog 1; bolA-like 1; bolA-like protein 1; down-regulated by herbal medicine with invigorating spleen and regulating qi in rat liver cancer", "tax_id": 10116, "disease": "", "pathway": " (rno:365875)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with the monothiol glutaredoxin GLRX5. May protect cells against oxidative stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:1990229 iron-sulfur cluster assembly complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q06C60-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0ZFS4-1", "uniprot_id": [ { "id": "Q0ZFS4_RAT", "url": "https://www.uniprot.org/uniprot/Q0ZFS4", "type": "external" } ], "mass": 13786.0, "length": 119, "protein_name": "Small ribosomal subunit protein mS33", "gene_name": "Mrps33", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mrps33", "gene_names_refseq": "", "protein_names_uniprotkb": "Small ribosomal subunit protein mS33", "protein_names_refseq": "", "tax_id": 10116, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (rno:296995); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0ZFS4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14U74-1", "uniprot_id": [ { "id": "Q14U74_RAT", "url": "https://www.uniprot.org/uniprot/Q14U74", "type": "external" } ], "mass": 92729.0, "length": 820, "protein_name": "Dolichyl-phosphate-mannose--protein mannosyltransferase", "gene_name": "Pomt2", "organism": "Rat", "refseq_name": "protein O-mannosyl-transferase 2", "refseq_ac": [ { "id": "NP_001040579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040579", "type": "external" } ], "gene_names_uniprotkb": "Pomt2", "gene_names_refseq": "Pomt2", "protein_names_uniprotkb": "Dolichyl-phosphate-mannose--protein mannosyltransferase; 2.4.1.109", "protein_names_refseq": "protein O-mannosyl-transferase 2", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Walker-Warburg syndrome (Disease Ontology:DOID:0050560); autosomal recessive limb-girdle muscular dystrophy (Disease Ontology:DOID:0110274); autosomal recessive limb-girdle muscular dystrophy type 2N (Disease Ontology:DOID:0110298); congenital muscular dystrophy-dystroglycanopathy type A2 (Disease Ontology:DOID:0111240); muscular dystrophy-dystroglycanopathy (Disease Ontology:DOID:0112374); muscular dystrophy-dystroglycanopathy type B2 (Disease Ontology:DOID:0112380); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (rno:688673); (R-RNO-8932504); (R-RNO-8932505); (R-RNO-8932506); (R-RNO-9768727)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins., [UniProtKB, UniProtKB]; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LRW3", "ec_number_list": [ { "id": "2.4.1.109", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.109", "type": "external" } ], "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex", "go_biological_process": "GO:1904100 positive regulation of protein O-linked glycosylation;GO:0006493 protein O-linked glycosylation;GO:0035269 protein O-linked glycosylation via mannose;GO:0021542 dentate gyrus development;GO:0071711 basement membrane organization", "synthesized_glycan_count": 1677, "hit_score": 0.4, "record_id": "Q14U74-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TGI4-1", "uniprot_id": [ { "id": "Q2TGI4_RAT", "url": "https://www.uniprot.org/uniprot/Q2TGI4", "type": "external" } ], "mass": 30809.0, "length": 279, "protein_name": "Palmitoyltransferase", "gene_name": "Zdhhc25", "organism": "Rat", "refseq_name": "zinc finger, DHHC-type containing 25", "refseq_ac": [ { "id": "NP_001034422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034422", "type": "external" } ], "gene_names_uniprotkb": "Zdhhc25", "gene_names_refseq": "DHHC26; Zdhhc25", "protein_names_uniprotkb": "Palmitoyltransferase; 2.3.1.225", "protein_names_refseq": "membrane-associated DHHC26 zinc finger protein; zinc finger, DHHC domain containing 25; zinc finger, DHHC-type containing 25", "tax_id": 10116, "disease": "", "pathway": " (rno:300323)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006612 protein targeting to membrane;GO:0008277 regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2TGI4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHS7-1", "uniprot_id": [ { "id": "Q3MHS7_RAT", "url": "https://www.uniprot.org/uniprot/Q3MHS7", "type": "external" } ], "mass": 42095.0, "length": 372, "protein_name": "GDP-mannose 4,6 dehydratase", "gene_name": "Gmds", "organism": "Rat", "refseq_name": "GDP-mannose 4,6 dehydratase", "refseq_ac": [ { "id": "NP_001034695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034695", "type": "external" } ], "gene_names_uniprotkb": "Gmds", "gene_names_refseq": "Gmds", "protein_names_uniprotkb": "GDP-mannose 4,6 dehydratase; 4.2.1.47; GDP-D-mannose dehydratase", "protein_names_refseq": "GDP-mannose 4,6 dehydratase", "tax_id": 10116, "disease": "open-angle glaucoma (Disease Ontology:DOID:1067)", "pathway": " (rno:291095); (R-RNO-6787639)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.47", "type": "external" } ], "go_molecular_function": "GO:0008446 GDP-mannose 4,6-dehydratase activity;GO:0042802 identical protein binding;GO:0070401 NADP+ binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0019673 GDP-mannose metabolic process;GO:0042351 'de novo' GDP-L-fucose biosynthetic process;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MHS7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ZAV4-1", "uniprot_id": [ { "id": "Q3ZAV4_RAT", "url": "https://www.uniprot.org/uniprot/Q3ZAV4", "type": "external" } ], "mass": 33171.0, "length": 290, "protein_name": "GTPase, IMAP family member 9", "gene_name": "Gimap9", "organism": "Rat", "refseq_name": "GTPase, IMAP family member 9", "refseq_ac": [ { "id": "NP_001008399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008399", "type": "external" } ], "gene_names_uniprotkb": "Gimap9", "gene_names_refseq": "Gimap9", "protein_names_uniprotkb": "GTPase, IMAP family member 9", "protein_names_refseq": "GTPase, IMAP family member 9", "tax_id": 10116, "disease": "", "pathway": " (rno:493865)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3ZAV4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q497C2-1", "uniprot_id": [ { "id": "Q497C2_RAT", "url": "https://www.uniprot.org/uniprot/Q497C2", "type": "external" } ], "mass": 30087.0, "length": 272, "protein_name": "Ribonuclease P/MRP subunit p38", "gene_name": "Rpp38", "organism": "Rat", "refseq_name": "ribonuclease P protein subunit p38", "refseq_ac": [ { "id": "NP_001028235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028235", "type": "external" } ], "gene_names_uniprotkb": "Rpp38", "gene_names_refseq": "Rpp38", "protein_names_uniprotkb": "Ribonuclease P/MRP subunit p38", "protein_names_refseq": "ribonuclease P protein subunit p38; ribonuclease P/MRP 38 subunit; ribonuclease P/MRP 38kDa subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:291317); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6JM24", "ec_number_list": [], "go_molecular_function": "GO:0004526 ribonuclease P activity;GO:0033204 ribonuclease P RNA binding", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0030681 multimeric ribonuclease P complex;GO:0001650 fibrillar center;GO:0000172 ribonuclease MRP complex;GO:0005730 nucleolus", "go_biological_process": "GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q497C2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q498R2-1", "uniprot_id": [ { "id": "Q498R2_RAT", "url": "https://www.uniprot.org/uniprot/Q498R2", "type": "external" } ], "mass": 19627.0, "length": 179, "protein_name": "Transcription factor 21", "gene_name": "Tcf21", "organism": "Rat", "refseq_name": "transcription factor 21", "refseq_ac": [ { "id": "NP_001027569", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027569", "type": "external" } ], "gene_names_uniprotkb": "Tcf21", "gene_names_refseq": "Capsulin; Msf-1; Pod1; Tcf21", "protein_names_uniprotkb": "Transcription factor 21", "protein_names_refseq": "transcription factor 21", "tax_id": 10116, "disease": "ventricular septal defect (Disease Ontology:DOID:1657); coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (rno:252856)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23034159;32661376", "class_list": "", "function": "Data suggest that Sry (sex determining region Y) and Tcf21 induce initial stages of embryonic Sertoli cell differentiation; Scx (scleraxis) induces later stages. This cascade--Sry>Tcf21>Scx--appears to promote subsequent sex differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor 21 expression in injured podocytes of glomerular diseases. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0042826 histone deacetylase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0007530 sex determination;GO:0060435 bronchiole development;GO:0072162 metanephric mesenchymal cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q498R2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZR8-1", "uniprot_id": [ { "id": "Q4FZR8_RAT", "url": "https://www.uniprot.org/uniprot/Q4FZR8", "type": "external" } ], "mass": 32116.0, "length": 280, "protein_name": "Four and a half LIM domains protein 1", "gene_name": "Fhl4", "organism": "Rat", "refseq_name": "four and a half LIM domains 4", "refseq_ac": [ { "id": "NP_001013190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013190", "type": "external" } ], "gene_names_uniprotkb": "Fhl4", "gene_names_refseq": "Fhl4", "protein_names_uniprotkb": "Four and a half LIM domains protein 1", "protein_names_refseq": "four and a half LIM domains 4", "tax_id": 10116, "disease": "myopathy (Disease Ontology:DOID:423)", "pathway": " (rno:314678)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May have an involvement in muscle development or hypertrophy. 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polymerase (RNA) III (DNA directed) polypeptide D, 44kDa; polymerase (RNA) III subunit D", "tax_id": 10116, "disease": "", "pathway": " (rno:306012); (R-RNO-76061); (R-RNO-76066); (R-RNO-76071)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0042797 tRNA transcription by RNA polymerase III;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription;GO:0045089 positive regulation of innate immune response;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4FZS9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZV1-1", "uniprot_id": [ { "id": "Q4FZV1_RAT", "url": "https://www.uniprot.org/uniprot/Q4FZV1", "type": "external" } ], "mass": 62050.0, "length": 560, "protein_name": "Serine incorporator 2", "gene_name": "Serinc2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Serinc2", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine incorporator 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:313057); 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alpha-defensin 8", "tax_id": 10116, "disease": "", "pathway": " (rno:613224); (R-RNO-1461973); (R-RNO-1462054); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4JEI6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7E6-1", "uniprot_id": [ { "id": "Q4V7E6_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7E6", "type": "external" } ], "mass": 49567.0, "length": 451, "protein_name": "WW domain containing transcription regulator 1", "gene_name": "Wwtr1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Wwtr1", "gene_names_refseq": "", "protein_names_uniprotkb": "WW domain containing transcription regulator 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "intestinal cancer (Disease Ontology:DOID:10155); heart disease (Disease Ontology:DOID:114); nephronophthisis (Disease Ontology:DOID:12712); neurodegenerative disease (Disease Ontology:DOID:1289); cancer (Disease Ontology:DOID:162); ovarian cancer (Disease Ontology:DOID:2394); carcinoma (Disease Ontology:DOID:305); nephrolithiasis (Disease Ontology:DOID:585)", "pathway": " (rno:295062); (R-RNO-2028269); (R-RNO-2032785); (R-RNO-2173796)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042803 protein homodimerization activity;GO:0003714 transcription corepressor activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation;GO:0060993 kidney morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V7E6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V895-1", "uniprot_id": [ { "id": "Q4V895_RAT", "url": "https://www.uniprot.org/uniprot/Q4V895", "type": "external" } ], "mass": 28243.0, "length": 258, "protein_name": "TNF receptor superfamily member 9", "gene_name": "Tnfrsf9", "organism": "Rat", "refseq_name": "tumor necrosis factor receptor superfamily member 9 precursor", "refseq_ac": [ { "id": "NP_001020944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020944", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf9", "gene_names_refseq": "4-1BB; 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MGC114427", "gene_names_refseq": "Magea9", "protein_names_uniprotkb": "MAGE family member A9", "protein_names_refseq": "uncharacterized protein LOC317297", "tax_id": 10116, "disease": "", "pathway": " (rno:317297)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6K515", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8H6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8Q2-1", "uniprot_id": [ { "id": "Q4V8Q2_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8Q2", "type": "external" } ], "mass": 56498.0, "length": 507, "protein_name": "Kunitz-type protease inhibitor 1", "gene_name": "Spint1", "organism": "Rat", "refseq_name": "kunitz-type protease inhibitor 1 precursor", "refseq_ac": [ { "id": "NP_001004265", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004265", "type": "external" } ], "gene_names_uniprotkb": "Spint1", "gene_names_refseq": "HAI-1; Spint1", "protein_names_uniprotkb": "Kunitz-type protease inhibitor 1; Hepatocyte growth factor activator inhibitor type 1", "protein_names_refseq": "hepatocyte growth factor activator inhibitor-1; kunitz-type protease inhibitor 1 precursor; kunitz-type protease inhibitor 1; serine protease inhibitor, Kunitz type 1", "tax_id": 10116, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); Alzheimer's disease (Disease Ontology:DOID:10652); biliary atresia (Disease Ontology:DOID:13608); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); liver cirrhosis (Disease Ontology:DOID:5082); stomach carcinoma (Disease Ontology:DOID:5517)", "pathway": " (rno:311331); (R-RNO-6806942); (R-RNO-8852405)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "20682770;23409135", "class_list": "", "function": "HAI-1 and HAI-2 influence proliferation and cell fate of NPCs and their expression levels are linked to BMP sign, [RefSeq, PubMed]; Identification of the matriptase second CUB domain as the secondary site for interaction with hepatocyte growth factor activator inhibitor type-1., [RefSeq, PubMed]; Inhibitor of HGFAC. Inhibits serine protease activity of ST14/matriptase in vitro. Inhibits serine protease activity of TMPRSS13, via the BPTI/Kunitz inhibitor 1 domain., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0060429 epithelium development;GO:0045687 positive regulation of glial cell differentiation;GO:0030198 extracellular matrix organization;GO:0008544 epidermis development;GO:0001843 neural tube closure", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4V8Q2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK58-1", "uniprot_id": [ { "id": "Q5BK58_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK58", "type": "external" } ], "mass": 41889.0, "length": 366, "protein_name": "C-C motif chemokine receptor 6", "gene_name": "Ccr6", "organism": "Rat", "refseq_name": "C-C chemokine receptor type 6", "refseq_ac": [ { "id": "NP_001013163", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013163", "type": "external" } ], "gene_names_uniprotkb": "Ccr6", "gene_names_refseq": "Ccr6", "protein_names_uniprotkb": "C-C motif chemokine receptor 6", "protein_names_refseq": "C-C chemokine receptor type 6; CC chemokine receptor 6; chemokine (C-C motif) receptor 6", "tax_id": 10116, "disease": "exanthem (Disease Ontology:DOID:0050486); primary cutaneous T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0060061); fungal infectious disease (Disease Ontology:DOID:1564); breast cancer (Disease Ontology:DOID:1612); transient cerebral ischemia (Disease Ontology:DOID:224); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); IgA glomerulonephritis (Disease Ontology:DOID:2986); systemic scleroderma (Disease Ontology:DOID:418); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (rno:308163); (R-RNO-1461957); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "22673903;26704184;29393594", "class_list": "", "function": "The results suggest a potential mechanism for the recruitment of IL-17-producing cells to degenerated intervertebral discs via a CCL20/CCR6 axis in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, 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calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0002523 leukocyte migration involved in inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5BK58-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0I6-1", "uniprot_id": [ { "id": "Q5I0I6_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0I6", "type": "external" } ], "mass": 24664.0, "length": 229, "protein_name": "Protein tyrosine phosphatase, receptor type, C-associated protein", "gene_name": "Ptprcap", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ptprcap", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein tyrosine phosphatase, receptor type, C-associated protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:499300)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5I0I6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0M4-1", "uniprot_id": [ { "id": "Q5I0M4_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0M4", "type": "external" } ], "mass": 37013.0, "length": 323, "protein_name": "Aldo-keto reductase family 1, member C12", "gene_name": "Akr1c12", "organism": "Rat", "refseq_name": "aldo-keto reductase family 1, member C12", "refseq_ac": [ { "id": "NP_001014262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014262", "type": "external" } ], "gene_names_uniprotkb": "Akr1c12", "gene_names_refseq": "Akr1c12; Akr1c13; BER1; LOCT364773; TBER1", "protein_names_uniprotkb": "Aldo-keto reductase family 1, member C12", "protein_names_refseq": "17beta-hydroxysteroid dehydrogenase; aldo-keto reductase family 1, member C12; aldo-keto reductase family 1, member C13; liver regeneration-related protein LRRG07", "tax_id": 10116, "disease": "", "pathway": " (rno:364773); (R-RNO-193368); (R-RNO-193775); (R-RNO-193807); (R-RNO-2162123); (R-RNO-5365859); (R-RNO-975634); (R-RNO-9757110)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "16788056;17888864", "class_list": "", "function": "Analysis of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases., [RefSeq, PubMed]; TBER1 represents a novel type of 17beta-hydroxysteroid dehydrogenase with unique catalytic properties and tissue distribution that is distinct from the type 5 isozyme., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MAE2", "ec_number_list": [], "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0047023 androsterone dehydrogenase [NAD(P)+] activity;GO:0032052 bile acid binding;GO:0047086 ketosteroid monooxygenase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006693 prostaglandin metabolic process;GO:0044597 daunorubicin metabolic process;GO:0044598 doxorubicin metabolic process;GO:0042448 progesterone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5I0M4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0Q2-1", "uniprot_id": [ { "id": "Q5I0Q2_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0Q2", "type": "external" } ], "mass": 41338.0, "length": 376, "protein_name": "SH2 domain containing 2A", "gene_name": "Sh2d2a", "organism": "Rat", "refseq_name": "SH2 domain-containing protein 2A", "refseq_ac": [ { "id": "NP_997488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997488", "type": "external" } ], "gene_names_uniprotkb": "Sh2d2a", "gene_names_refseq": "Sh2d2a", "protein_names_uniprotkb": "SH2 domain containing 2A", "protein_names_refseq": "SH2 domain protein 2A; SH2 domain-containing protein 2A", "tax_id": 10116, "disease": "multiple sclerosis (Disease Ontology:DOID:2377); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676)", "pathway": " (rno:310688); (R-RNO-4420097)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15300336", "class_list": "", "function": "May have a regulatory role in cellular activation of T and NK cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0042110 T cell activation;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5I0Q2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M7U1-1", "uniprot_id": [ { "id": "Q5M7U1_RAT", "url": "https://www.uniprot.org/uniprot/Q5M7U1", "type": "external" } ], "mass": 36931.0, "length": 319, "protein_name": "F-box only protein 8", "gene_name": "Fbxo8", "organism": "Rat", "refseq_name": "F-box only protein 8", "refseq_ac": [ { "id": "NP_001012050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012050", "type": "external" } ], "gene_names_uniprotkb": "Fbxo8", "gene_names_refseq": "Fbxo8", "protein_names_uniprotkb": "F-box only protein 8", "protein_names_refseq": "F-box only protein 8", "tax_id": 10116, "disease": "", "pathway": " (rno:306436)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1M701", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0032012 regulation of ARF protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M7U1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M830-1", "uniprot_id": [ { "id": "Q5M830_RAT", "url": "https://www.uniprot.org/uniprot/Q5M830", "type": "external" } ], "mass": 40479.0, "length": 356, "protein_name": "Replication factor C subunit 3", "gene_name": "Rfc3", "organism": "Rat", "refseq_name": "replication factor C subunit 3", "refseq_ac": [ { "id": "NP_001009629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009629", "type": "external" } ], "gene_names_uniprotkb": "Rfc3", "gene_names_refseq": "Rfc3", "protein_names_uniprotkb": "Replication factor C subunit 3; Activator 1 38 kDa subunit; Activator 1 subunit 3; Replication factor C 38 kDa subunit", "protein_names_refseq": "replication factor C (activator 1) 3; replication factor C 3; replication factor C subunit 3", "tax_id": 10116, "disease": "", "pathway": " (rno:288414); (R-RNO-110312); (R-RNO-110314); (R-RNO-110320); (R-RNO-174411); (R-RNO-176187); (R-RNO-5651801); (R-RNO-5655862); (R-RNO-5656121); (R-RNO-5656169); (R-RNO-5685938); (R-RNO-5685942); (R-RNO-5693537); (R-RNO-5693607); (R-RNO-5696397); (R-RNO-5696400); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6804756); (R-RNO-69091); (R-RNO-69473)", "pathway_count": 21, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008094 ATP-dependent activity, acting on DNA", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031390 Ctf18 RFC-like complex;GO:0005663 DNA replication factor C complex;GO:0031389 Rad17 RFC-like complex", "go_biological_process": "GO:0006271 DNA strand elongation involved in DNA replication;GO:0006281 DNA repair;GO:0006260 DNA replication;GO:1900264 positive regulation of DNA-directed DNA polymerase activity;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M830-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJP6-1", "uniprot_id": [ { "id": "Q5RJP6_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJP6", "type": "external" } ], "mass": 50393.0, "length": 473, "protein_name": "Solute carrier family 10, member 3", "gene_name": "Slc10a3", "organism": "Rat", "refseq_name": "P3 protein", "refseq_ac": [ { "id": "NP_001019539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019539", "type": "external" } ], "gene_names_uniprotkb": "Slc10a3", "gene_names_refseq": "Slc10a3", "protein_names_uniprotkb": "Solute carrier family 10, member 3", "protein_names_refseq": "P3 protein; solute carrier family 10 (sodium/bile acid cotransporter family), member 3", "tax_id": 10116, "disease": "", "pathway": " (rno:501665)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8I5ZW70", "ec_number_list": [], "go_molecular_function": "GO:0008508 bile acid:sodium symporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0015721 bile acid and bile salt transport;GO:0032526 response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RJP6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2T2-1", "uniprot_id": [ { "id": "Q5U2T2_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2T2", "type": "external" } ], "mass": 38659.0, "length": 334, "protein_name": "Alkyl transferase", "gene_name": "Dhdds", "organism": "Rat", "refseq_name": "dehydrodolichyl diphosphate synthase complex subunit DHDDS isoform X1", "refseq_ac": [ { "id": "XP_063143515", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063143515", "type": "external" } ], "gene_names_uniprotkb": "Dhdds", "gene_names_refseq": "Dhdds", "protein_names_uniprotkb": "Alkyl transferase; 2.5.1.-", "protein_names_refseq": "dehydrodolichyl diphosphate synthase complex subunit DHDDS isoform X1", "tax_id": 10116, "disease": "developmental delay and seizures with or without movement abnormalities (Disease Ontology:DOID:0080473); retinitis pigmentosa 59 (Disease Ontology:DOID:0110352); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:298541); (R-RNO-446199)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length. Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.87", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.87", "type": "external" }, { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0045547 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:1904423 dehydrodolichyl diphosphate synthase complex", "go_biological_process": "GO:0043048 dolichyl monophosphate biosynthetic process;GO:0006489 dolichyl diphosphate biosynthetic process;GO:0016094 polyprenol biosynthetic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2T2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U3Z2-1", "uniprot_id": [ { "id": "Q5U3Z2_RAT", "url": "https://www.uniprot.org/uniprot/Q5U3Z2", "type": "external" } ], "mass": 17796.0, "length": 160, "protein_name": "Growth arrest and DNA-damage-inducible, beta", "gene_name": "Gadd45b", "organism": "Rat", "refseq_name": "growth arrest and DNA damage-inducible protein GADD45 beta", "refseq_ac": [ { "id": "NP_001008322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008322", "type": "external" } ], "gene_names_uniprotkb": "Gadd45b", "gene_names_refseq": "Gadd45b", "protein_names_uniprotkb": "Growth arrest and DNA-damage-inducible, beta", "protein_names_refseq": "growth arrest and DNA damage-inducible protein GADD45 beta; growth arrest and DNA-damage-inducible 45 beta", "tax_id": 10116, "disease": "", "pathway": " (rno:299626)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16528573;18977442;27590577;31043581;33421485;33784505;37988908", "class_list": "", "function": "Data show that nonylphenol (NP) increased serum alkaline phosphatase, lead to liver damage and can increase the expression of heme oxygenase-1 (HO1) and growth arrest and DNA-damage-inducible 45 beta protein (Gadd45b) genes and may modify the toxic effects on liver through induction of oxidative stress., [RefSeq, PubMed]; Downregulation of Gadd45beta alleviates osteoarthritis by repressing lipopolysaccharide-induced fibroblast-like synoviocyte inflammation, proliferation and migration., [RefSeq, PubMed]; Gadd45b is a novel mediator of depression-like behaviors and neuroinflammation after cerebral ischemia., [RefSeq, PubMed]; Gadd45b mediates environmental enrichment-induced neurogenesis in the SVZ of rats following ischemia stroke via BDNF., [RefSeq, PubMed]; Inadequate induction of Gadd45b, which encodes a novel beta cell JNK and ERK inhibitor, may in part explain the pro-apoptotic response of beta cells to IL-1beta., [RefSeq, PubMed]; RGC5 cells, a transformed retinal ganglion (RGC) cell line, were used to demonstrate the function of Gadd45b in survival of RGC5 in response to paraquat oxidative stress, TNFalpha cytotoxicity and glutamate excitotoxicity, [RefSeq, PubMed]; The results suggest that the ALK5 signaling pathway plays a critical role in mediating neural plasticity and neurological function recovery via Gadd45b after cerebral ischemia. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade;GO:0046330 positive regulation of JNK cascade;GO:0006469 negative regulation of protein kinase activity;GO:1900745 positive regulation of p38MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5U3Z2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5USB8-1", "uniprot_id": [ { "id": "Q5USB8_RAT", "url": "https://www.uniprot.org/uniprot/Q5USB8", "type": "external" } ], "mass": 34250.0, "length": 311, "protein_name": "Olfactory receptor", "gene_name": "Or8s8", "organism": "Rat", "refseq_name": "olfactory receptor Olr1108", "refseq_ac": [ { "id": "NP_001000993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000993", "type": "external" } ], "gene_names_uniprotkb": "Or8s8", "gene_names_refseq": "Olr1108; Or8s8", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1108; olfactory receptor MOR160-5 like protein; olfactory receptor Olr1108; olfactory receptor gene Olr1108", "tax_id": 10116, "disease": "", "pathway": " (rno:405353)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Possible taste receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5USB8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5USB9-1", "uniprot_id": [ { "id": "Q5USB9_RAT", "url": "https://www.uniprot.org/uniprot/Q5USB9", "type": "external" } ], "mass": 33798.0, "length": 308, "protein_name": "Olfactory receptor", "gene_name": "Or8s10", "organism": "Rat", "refseq_name": "olfactory receptor Olr1107", "refseq_ac": [ { "id": "NP_001000424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000424", "type": "external" } ], "gene_names_uniprotkb": "Or8s10", "gene_names_refseq": "Olr1107; Or8s10", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1107; olfactory receptor Olr1107; olfactory receptor gene Olr1107", "tax_id": 10116, "disease": "", "pathway": " (rno:300202)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Possible taste receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5USB9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5USC0-1", "uniprot_id": [ { "id": "Q5USC0_RAT", "url": "https://www.uniprot.org/uniprot/Q5USC0", "type": "external" } ], "mass": 34187.0, "length": 317, "protein_name": "Olfactory receptor", "gene_name": "Or10ac1", "organism": "Rat", "refseq_name": "olfactory receptor Olr804", "refseq_ac": [ { "id": "NP_001000852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000852", "type": "external" } ], "gene_names_uniprotkb": "Or10ac1", "gene_names_refseq": "Olr804; Or10ac1", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 804; olfactory receptor MOR0-2 like protein; olfactory receptor Olr804; olfactory receptor gene Olr804", "tax_id": 10116, "disease": "", "pathway": " (rno:405142)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5USC0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI34-1", "uniprot_id": [ { "id": "Q5XI34_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI34", "type": "external" } ], "mass": 65323.0, "length": 589, "protein_name": "Protein phosphatase 2 scaffold subunit A alpha", "gene_name": "Ppp2r1a", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "refseq_ac": [ { "id": "NP_476481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476481", "type": "external" } ], "gene_names_uniprotkb": "Ppp2r1a", "gene_names_refseq": "PR65; Ppp2r1a", "protein_names_uniprotkb": "Protein phosphatase 2 scaffold subunit A alpha", "protein_names_refseq": "protein phosphatase 2, regulatory subunit A, alpha; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder 36 (Disease Ontology:DOID:0070066)", "pathway": " (rno:117281); (R-RNO-113501); (R-RNO-1295596); (R-RNO-141430); (R-RNO-141444); (R-RNO-180024); (R-RNO-195253); (R-RNO-196299); (R-RNO-198753); (R-RNO-202670); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-2565942); (R-RNO-2995383); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-389356); (R-RNO-389513); (R-RNO-432142); (R-RNO-4641262); (R-RNO-5620912); (R-RNO-5663220); (R-RNO-5673000); (R-RNO-5675221); (R-RNO-6804757); (R-RNO-6811558); (R-RNO-68877); (R-RNO-69231); (R-RNO-69273); (R-RNO-8854518); (R-RNO-9648025); (R-RNO-975957); (R-RNO-9833482); (R-RNO-9860927)", "pathway_count": 36, "publication_count": 1, "publication_id_list": "24465463", "class_list": "", "function": "PR65A phosphorylation regulates PP2A complex signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0046982 protein heterodimerization activity;GO:0004722 protein serine/threonine phosphatase activity;GO:1990405 protein antigen binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex;GO:0098978 glutamatergic synapse", "go_biological_process": "GO:0051754 meiotic sister chromatid cohesion, centromeric;GO:0051225 spindle assembly;GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0007059 chromosome segregation;GO:0070262 peptidyl-serine dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XI34-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIP0-1", "uniprot_id": [ { "id": "Q5XIP0_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIP0", "type": "external" } ], "mass": 37822.0, "length": 337, "protein_name": "DnaJ heat shock protein family (Hsp40) member B4", "gene_name": "Dnajb4", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily B member 4", "refseq_ac": [ { "id": "NP_001013094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013094", "type": "external" } ], "gene_names_uniprotkb": "Dnajb4", "gene_names_refseq": "Dnajb4", "protein_names_uniprotkb": "DnaJ heat shock protein family (Hsp40) member B4", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 4-like; 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2.7.2.3", "protein_names_refseq": "phosphoglycerate kinase 2", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:316265); (R-RNO-70171); (R-RNO-70263)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6JJ65", "ec_number_list": [ { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0004618 phosphoglycerate kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0043531 ADP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005929 cilium;GO:0035686 sperm fibrous sheath;GO:0005737 cytoplasm", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0006094 gluconeogenesis;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIV1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63394-1", "uniprot_id": [ { "id": "Q63394_RAT", "url": "https://www.uniprot.org/uniprot/Q63394", "type": "external" } ], "mass": 35434.0, "length": 313, "protein_name": "Olfactory receptor", "gene_name": "Or2b2", "organism": "Rat", "refseq_name": "olfactory receptor Olr1654", "refseq_ac": [ { "id": "NP_068632", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068632", "type": "external" } ], "gene_names_uniprotkb": "Or2b2", "gene_names_refseq": "Ol1; Olr1654; Or2b2", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1654; olfactory receptor Olr1654; olfactory receptor gene Olr1654", "tax_id": 10116, "disease": "", "pathway": " (rno:60451)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8589991", "class_list": "", "function": "OL1 transcripts to be not only expressed in the olfactory epithelium, but also in the heart. This unexpected cardiac expression was developmentally regulated, being maximal at early postnatal stages and hardly detectable at adult stages., [RefSeq, PubMed]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63394-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXY8-1", "uniprot_id": [ { "id": "Q6AXY8_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXY8", "type": "external" } ], "mass": 34015.0, "length": 313, "protein_name": "Dehydrogenase/reductase SDR family member 1", "gene_name": "Dhrs1", "organism": "Rat", "refseq_name": "dehydrogenase/reductase SDR family member 1", "refseq_ac": [ { "id": "NP_001007622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007622", "type": "external" } ], "gene_names_uniprotkb": "Dhrs1", "gene_names_refseq": "Dhrs1", "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 1; Short chain dehydrogenase/reductase family 19C member 1", "protein_names_refseq": "dehydrogenase/reductase (SDR family) member 1; dehydrogenase/reductase SDR family member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:290234)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.122", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.122", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.104", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.64", "type": "external" } ], "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0004090 carbonyl reductase (NADPH) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXY8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYC6-1", "uniprot_id": [ { "id": "Q6AYC6_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYC6", "type": "external" } ], "mass": 39133.0, "length": 367, "protein_name": "ABI gene family member 3", "gene_name": "Abi3", "organism": "Rat", "refseq_name": "ABI gene family member 3", "refseq_ac": [ { "id": "NP_001013136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013136", "type": "external" } ], "gene_names_uniprotkb": "Abi3", "gene_names_refseq": "Abi3", "protein_names_uniprotkb": "ABI gene family member 3; New molecule including SH3", "protein_names_refseq": "ABI gene family member 3; ABI gene family, member 3; NESH protein", "tax_id": 10116, "disease": "", "pathway": " (rno:303476)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0030027 lamellipodium;GO:0098794 postsynapse;GO:0031209 SCAR complex", "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0001764 neuron migration;GO:0030334 regulation of cell migration;GO:1903077 negative regulation of protein localization to plasma membrane;GO:2000774 positive regulation of cellular senescence", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYC6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYL0-1", "uniprot_id": [ { "id": "TPC_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYL0", "type": "external" } ], "mass": 35638.0, "length": 318, "protein_name": "Mitochondrial thiamine pyrophosphate carrier", "gene_name": "Slc25a19", "organism": "Rat", "refseq_name": "mitochondrial thiamine pyrophosphate carrier", "refseq_ac": [ { "id": "NP_001007675", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007675", "type": "external" } ], "gene_names_uniprotkb": "Slc25a19; LOC100910173", "gene_names_refseq": "Slc25a19", "protein_names_uniprotkb": "Mitochondrial thiamine pyrophosphate carrier; Mitochondrial uncoupling protein 1; Solute carrier family 25 member 19", "protein_names_refseq": "mitochondrial thiamine pyrophosphate carrier; mitochondrial uncoupling protein 1; solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 19; solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19", "tax_id": 10116, "disease": "microcephaly (Disease Ontology:DOID:10907); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": " (rno:303676); (R-RNO-196819)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17035501;37529835", "class_list": "", "function": "MiR-122-5p is involved in posttranscriptional regulation of the mitochondrial thiamin pyrophosphate transporter (SLC25A19) in pancreatic acinar cells., [RefSeq, PubMed]; Mitochondria of Slc25a19(-/-) and Amish lethal microcephaly cells have undetectable and markedly reduced thiamine pyrophosphate content, respectively, [RefSeq, PubMed]; Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria. It is not clear if the antiporter activity is affected by the membrane potential or by the proton electrochemical gradient., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0090422 thiamine pyrophosphate transmembrane transporter activity;GO:0015234 thiamine transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0016020 membrane", "go_biological_process": "GO:0009229 thiamine diphosphate biosynthetic process;GO:0030974 thiamine pyrophosphate transmembrane transport;GO:0042723 thiamine-containing compound metabolic process;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AYL0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AZ42-1", "uniprot_id": [ { "id": "Q6AZ42_RAT", "url": "https://www.uniprot.org/uniprot/Q6AZ42", "type": "external" } ], "mass": 30366.0, "length": 261, "protein_name": "Gap junction protein", "gene_name": "Gjb6", "organism": "Rat", "refseq_name": "gap junction beta-6 protein", "refseq_ac": [ { "id": "NP_001380735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001380735", "type": "external" } ], "gene_names_uniprotkb": "Gjb6", "gene_names_refseq": "Cx30; Cxnf; Gjb6", "protein_names_uniprotkb": "Gap junction protein", "protein_names_refseq": "connexin f; gap junction beta-6 protein; gap junction membrane channel protein beta 6; gap junction protein, beta 6 (connexin 30)", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 1A (Disease Ontology:DOID:0110475); autosomal recessive nonsyndromic deafness 1B (Disease Ontology:DOID:0110476); autosomal dominant nonsyndromic deafness 3B (Disease Ontology:DOID:0110565); Clouston syndrome (Disease Ontology:DOID:14693); status epilepticus (Disease Ontology:DOID:1824); ectodermal dysplasia (Disease Ontology:DOID:2121); transient cerebral ischemia (Disease Ontology:DOID:224); borna disease (Disease Ontology:DOID:5154); ureteral obstruction (Disease Ontology:DOID:5199)", "pathway": " (rno:84403); (R-RNO-190861)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "24301293;27130897;28875331;32462383", "class_list": "", "function": "Connexin 30 mediated rewiring of glucose metabolism in rat C6 xenograft and grades of glioma., [RefSeq, PubMed]; Investigation of stemness-related CD133 and cMyc in human samples and rat xenografts exhibited a reciprocal relationship between Cx30 and IGF-1R in the low and high grades (HG) of glioma. Cx30 was completely abolished in HG; levels of IGF-1R, CD133 and cMyc expression were positively correlated with HG. Cx30 transfection could attenuate the malignant burden of glioma in rat xenografts. Erratum:[J Neurooncol. 2021 May;152(3):621-622. PMID: 33761056], [RefSeq, PubMed]; Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage. Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response., [UniProtKB, UniProtKB]; Study demonstrates that connexin 30 has the potential to alter the Insulin-like growth factor-1 receptor mediated pathway thereby influencing the growth, proliferation and migration of glioma cells., [RefSeq, PubMed]; These results illustrate that astroglial connexins 30 and 43 contribute to hypothalamic GS., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6KHB3", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0051015 actin filament binding;GO:0048487 beta-tubulin binding;GO:1903763 gap junction channel activity involved in cell communication by electrical coupling;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005884 actin filament;GO:0030054 cell junction;GO:0016324 apical plasma membrane;GO:0005921 gap junction;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0008285 negative regulation of cell population proliferation;GO:0032496 response to lipopolysaccharide;GO:0055085 transmembrane transport;GO:0071333 cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6AZ42-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MFX4-1", "uniprot_id": [ { "id": "Q6MFX4_RAT", "url": "https://www.uniprot.org/uniprot/Q6MFX4", "type": "external" } ], "mass": 34804.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or2h2c", "organism": "Rat", "refseq_name": "olfactory receptor 1746", "refseq_ac": [ { "id": "NP_001001427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001427", "type": "external" } ], "gene_names_uniprotkb": "Or2h2c", "gene_names_refseq": "Olr1746; Or2h2c; Or5", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1746; olfactory receptor 5; olfactory receptor gene Olr1746", "tax_id": 10116, "disease": "", "pathway": " (rno:405201)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6MFX4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDU2-1", "uniprot_id": [ { "id": "Q6PDU2_RAT", "url": "https://www.uniprot.org/uniprot/Q6PDU2", "type": "external" } ], "mass": 22519.0, "length": 200, "protein_name": "Large ribosomal subunit protein mL66", "gene_name": "Mrps18a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mrps18a", "gene_names_refseq": "", "protein_names_uniprotkb": "Large ribosomal subunit protein mL66", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:301249); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070181 small ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PDU2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QDX6-1", "uniprot_id": [ { "id": "Q6QDX6_RAT", "url": "https://www.uniprot.org/uniprot/Q6QDX6", "type": "external" } ], "mass": 17399.0, "length": 153, "protein_name": "Ribonuclease K6", "gene_name": "Rnase6", "organism": "Rat", "refseq_name": "ribonuclease K6 precursor", "refseq_ac": [ { "id": "NP_996538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996538", "type": "external" } ], "gene_names_uniprotkb": "Rnase6", "gene_names_refseq": "Rnase6", "protein_names_uniprotkb": "Ribonuclease K6", "protein_names_refseq": "RNase 6; ribonuclease A family member k6; ribonuclease K6 precursor; ribonuclease K6-like; ribonuclease K6; ribonuclease, RNase A family, 6; ribonuclease, RNase A family, k6", "tax_id": 10116, "disease": "", "pathway": " (rno:305842); (R-RNO-6803157)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli. Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0004519 endonuclease activity;GO:0004540 RNA nuclease activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6QDX6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6SJV7-1", "uniprot_id": [ { "id": "Q6SJV7_RAT", "url": "https://www.uniprot.org/uniprot/Q6SJV7", "type": "external" } ], "mass": 22893.0, "length": 208, "protein_name": "Gastrokine-1", "gene_name": "Gkn1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gkn1", "gene_names_refseq": "", "protein_names_uniprotkb": "Gastrokine-1; 18 kDa antrum mucosa protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:297418)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6SJV7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TXF4-1", "uniprot_id": [ { "id": "Q6TXF4_RAT", "url": "https://www.uniprot.org/uniprot/Q6TXF4", "type": "external" } ], "mass": 14006.0, "length": 127, "protein_name": "Uncharacterized protein", "gene_name": "Fam19a5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fam19a5", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6TXF4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811X3-1", "uniprot_id": [ { "id": "Q811X3_RAT", "url": "https://www.uniprot.org/uniprot/Q811X3", "type": "external" } ], "mass": 36050.0, "length": 328, "protein_name": "Carbonic anhydrase-related protein 11", "gene_name": "Ca11", "organism": "Rat", "refseq_name": "carbonic anhydrase-related protein 11 precursor", "refseq_ac": [ { "id": "NP_783639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783639", "type": "external" } ], "gene_names_uniprotkb": "Ca11; Car11", "gene_names_refseq": "CAR-XI; Ca11; Car11", "protein_names_uniprotkb": "Carbonic anhydrase-related protein 11; CA-RP XI", "protein_names_refseq": "carbonic anhydrase-related XI protein; carbonic anhydrase-related protein 11 precursor; carbonic anhydrase-related protein 11", "tax_id": 10116, "disease": "", "pathway": " (rno:308588)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Does not have a catalytic activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016836 hydro-lyase activity;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0016323 basolateral plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q811X3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CH33-1", "uniprot_id": [ { "id": "Q8CH33_RAT", "url": "https://www.uniprot.org/uniprot/Q8CH33", "type": "external" } ], "mass": 41977.0, "length": 369, "protein_name": "C-C motif chemokine receptor 9", "gene_name": "Ccr9", "organism": "Rat", "refseq_name": "C-C chemokine receptor type 9", "refseq_ac": [ { "id": "NP_758832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758832", "type": "external" } ], "gene_names_uniprotkb": "Ccr9", "gene_names_refseq": "Ccr9", "protein_names_uniprotkb": "C-C motif chemokine receptor 9", "protein_names_refseq": "C-C chemokine receptor type 9; chemokine (C-C motif) receptor 9", "tax_id": 10116, "disease": "asthma (Disease Ontology:DOID:2841)", "pathway": " (rno:282832); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21672573;27146447;29269409", "class_list": "", "function": "In cardiomyoctes in vitro, CCR9 deficiency markedly inhibited Ang II-induced hypertrophic response, whereas CCR9 overexpression clearly enhanced the response. Publication Status: Online-Only, [RefSeq, PubMed]; N-{4-Chloro-2-[(1-oxidopyridin-4-yl)carbonyl]phenyl}-4-(propan-2- yloxy)benzenesulfonamide (MLN3126) is an orally available chemokine C-C motif receptor 9 selective antagonist., [RefSeq, PubMed]; Through its receptor Ccr9, thymus-expressed chemokine TECK promotes survival of serum-deprived PC12 cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CH33-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K453-1", "uniprot_id": [ { "id": "Q8K453_RAT", "url": "https://www.uniprot.org/uniprot/Q8K453", "type": "external" } ], "mass": 11730.0, "length": 99, "protein_name": "C-X-C motif chemokine 14", "gene_name": "Cxcl14", "organism": "Rat", "refseq_name": "C-X-C motif chemokine 14 precursor", "refseq_ac": [ { "id": "NP_001013155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013155", "type": "external" } ], "gene_names_uniprotkb": "Cxcl14", "gene_names_refseq": "BRAK; Cxcl14", "protein_names_uniprotkb": "C-X-C motif chemokine 14; Chemokine BRAK; MIP-2G; Small-inducible cytokine B14", "protein_names_refseq": "C-X-C motif chemokine 14 precursor; C-X-C motif chemokine 14; chemokine (C-X-C motif) ligand 14", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); asthma (Disease Ontology:DOID:2841)", "pathway": " (rno:306748)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20974226;21462317;31640472;33070779;38750454", "class_list": "", "function": "Differential expression of cxcl-14 during eruptive movement of rat molar germs, [RefSeq, PubMed]; IRX1 hypermethylation promotes heart failure by inhibiting CXCL14 expression., [RefSeq, PubMed]; NFATc2-dependent epigenetic upregulation of CXCL14 is involved in the development of neuropathic pain induced by paclitaxel. Publication Status: Online-Only, [RefSeq, PubMed]; PAX6/CXCL14 regulatory axis promotes the repair of corneal injury by enhancing corneal epithelial cell proliferation. Publication Status: Online-Only, [RefSeq, PubMed]; These results demonstrated for the first time that CXCL14 protein is present in a subset of hypothalamic neurons, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D4A5S7", "ec_number_list": [], "go_molecular_function": "GO:0008009 chemokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0048839 inner ear development;GO:0045662 negative regulation of myoblast differentiation;GO:2000503 positive regulation of natural killer cell chemotaxis;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K453-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4I6-1", "uniprot_id": [ { "id": "Q8R4I6_RAT", "url": "https://www.uniprot.org/uniprot/Q8R4I6", "type": "external" } ], "mass": 103013.0, "length": 900, "protein_name": "Actinin alpha 3", "gene_name": "Actn3", "organism": "Rat", "refseq_name": "alpha-actinin-3", "refseq_ac": [ { "id": "NP_596915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596915", "type": "external" } ], "gene_names_uniprotkb": "Actn3", "gene_names_refseq": "Actn3", "protein_names_uniprotkb": "Actinin alpha 3", "protein_names_refseq": "alpha-actinin-3", "tax_id": 10116, "disease": "focal segmental glomerulosclerosis 1 (Disease Ontology:DOID:0111128)", "pathway": " (rno:171009); (R-RNO-390522)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005925 focal adhesion;GO:0030054 cell junction;GO:0001725 stress fiber", "go_biological_process": "GO:1901078 negative regulation of relaxation of muscle;GO:0030036 actin cytoskeleton organization;GO:0014728 regulation of the force of skeletal muscle contraction;GO:0014732 skeletal muscle atrophy;GO:0014883 transition between fast and slow fiber", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R4I6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VI81-1", "uniprot_id": [ { "id": "Q8VI81_RAT", "url": "https://www.uniprot.org/uniprot/Q8VI81", "type": "external" } ], "mass": 25207.0, "length": 218, "protein_name": "Fibroblast growth factor", "gene_name": "Fgf19", "organism": "Rat", "refseq_name": "fibroblast growth factor 19 precursor", "refseq_ac": [ { "id": "NP_570109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570109", "type": "external" } ], "gene_names_uniprotkb": "Fgf19", "gene_names_refseq": "Fgf15; Fgf19; Fgf8a", "protein_names_uniprotkb": "Fibroblast growth factor; FGF", "protein_names_refseq": "fibroblast growth factor 15; fibroblast growth factor 19 precursor; fibroblast growth factor 8a", "tax_id": 10116, "disease": "alcoholic hepatitis (Disease Ontology:DOID:12351)", "pathway": " (rno:170582); (R-RNO-109704); (R-RNO-1257604); (R-RNO-1307965); (R-RNO-190322); (R-RNO-5654228); (R-RNO-5654712); (R-RNO-5654719); (R-RNO-5654720); (R-RNO-5654733); (R-RNO-5673001); (R-RNO-6811558)", "pathway_count": 12, "publication_count": 5, "publication_id_list": "28946907;29198707;31288013;31847428;36608639", "class_list": "", "function": "FGF19 improves sevoflurane-induced cognitive dysfunction in rats through the PGC-1alpha/BDNF/FNDC5 pathway., [RefSeq, PubMed]; In summary, the present study provides the first comprehensive analysis of the critical role of the vagus nerve in regulating BA metabolism and signaling pathway., [RefSeq, PubMed]; Plasma level in glucose intolerance correlated with FXR mRNA expression in colon Publication Status: Online-Only, [RefSeq, PubMed]; The Effect of Fibroblast Growth Factor 15 Signaling in Non-Steatotic and Steatotic Liver Transplantation from Cardiocirculatory Death. Publication Status: Online-Only, [RefSeq, PubMed]; The increased CDCAs concentrations activated Fxr-Fgf15 pathway in ileum to result in the mRNA expression of Cyp7a1 in liver down-regulation, which inhibited cholesterol metabolizing into primary BAs to contribute to the cholesterol level increase in liver tissue in HFD-induced obesity rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6HYH6", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation;GO:0010629 negative regulation of gene expression;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VI81-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZP2-1", "uniprot_id": [ { "id": "Q91ZP2_RAT", "url": "https://www.uniprot.org/uniprot/Q91ZP2", "type": "external" } ], "mass": 8528.0, "length": 77, "protein_name": "Dcm5 protein", "gene_name": "Dcm5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dcm5", "gene_names_refseq": "", "protein_names_uniprotkb": "Dcm5 protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q91ZP2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJI7-1", "uniprot_id": [ { "id": "Q9JJI7_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJI7", "type": "external" } ], "mass": 94956.0, "length": 855, "protein_name": "Suppressor of tumorigenicity 14 protein homolog", "gene_name": "St14", "organism": "Rat", "refseq_name": "suppressor of tumorigenicity 14 protein", "refseq_ac": [ { "id": "NP_446087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446087", "type": "external" } ], "gene_names_uniprotkb": "St14", "gene_names_refseq": "MT-SP1; St14", "protein_names_uniprotkb": "Suppressor of tumorigenicity 14 protein homolog; 3.4.21.109; Serine protease 14", "protein_names_refseq": "membrane-type serine protease; suppression of tumorigenicity 14 (colon carcinoma); suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin); suppressor of tumorigenicity 14 protein", "tax_id": 10116, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); autosomal recessive congenital ichthyosis 11 (Disease Ontology:DOID:0060720); Sjogren's syndrome (Disease Ontology:DOID:12894); granulosa cell tumor (Disease Ontology:DOID:2999); dysgerminoma (Disease Ontology:DOID:4441); renal cell carcinoma (Disease Ontology:DOID:4450); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (rno:114093)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19800422;19897900;20682770;22673903;23038671", "class_list": "", "function": "Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing. Proteolytically cleaves and therefore activates TMPRSS13., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Identification of the matriptase second CUB domain as the secondary site for interaction with hepatocyte growth factor activator inhibitor type-1., [RefSeq, PubMed]; Investigation of protein structure of matriptase and the structural effects on kinetics of proteolysis and zymogen activation, [RefSeq, PubMed]; Matriptase C-terminal fragments containing the catalytic serine protease domain were found to occur on the apical and basolateral sides of Madin-Darby canine kidney epithelial cells transfected with a cDNA encoding the protease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1LRR7", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005615 extracellular space;GO:0016323 basolateral plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0016485 protein processing;GO:0030216 keratinocyte differentiation;GO:0006508 proteolysis;GO:0030855 epithelial cell differentiation;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JJI7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000100000000.010.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R005-1", "uniprot_id": [ { "id": "Q9R005_RAT", "url": "https://www.uniprot.org/uniprot/Q9R005", "type": "external" } ], "mass": 27821.0, "length": 245, "protein_name": "Prolactin family 7, subfamily D, member 1", "gene_name": "Prl7d1", "organism": "Rat", "refseq_name": "prolactin-7D1 precursor", "refseq_ac": [ { "id": "NP_445816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445816", "type": "external" } ], "gene_names_uniprotkb": "Prl7d1", "gene_names_refseq": "PRP; Plfr; Prl7d1", "protein_names_uniprotkb": "Prolactin family 7, subfamily D, member 1", "protein_names_refseq": "prolactin-7D1 precursor; prolactin-7D1; proliferin related protein", "tax_id": 10116, "disease": "", "pathway": " (rno:84377)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21679748", "class_list": "", "function": "Data suggest that proliferin-related protein is regulated by HCG and plays roles in male reproduction, such as testosterone production., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6J7Q5", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0046872 metal ion binding;GO:0005125 cytokine activity;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9R005-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JWZ3-1", "uniprot_id": [ { "id": "A0A0G2JWZ3_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JWZ3", "type": "external" } ], "mass": 96975.0, "length": 846, "protein_name": "Gamma-secretase activating protein", "gene_name": "Gsap", "organism": "Rat", "refseq_name": "gamma-secretase-activating protein", "refseq_ac": [ { "id": "NP_001381957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001381957", "type": "external" } ], "gene_names_uniprotkb": "Gsap", "gene_names_refseq": "Gsap; Pion", "protein_names_uniprotkb": "Gamma-secretase activating protein", "protein_names_refseq": "gamma-secretase-activating protein; protein pigeon homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:311984)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23209290", "class_list": "", "function": "Gamma-secretase activating protein (GSAP) and imatinib have roles in the regulation of gamma-secretase activity and amyloid-beta generation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005802 trans-Golgi network", "go_biological_process": "GO:1902004 positive regulation of amyloid-beta formation;GO:0030162 regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JWZ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JY13-1", "uniprot_id": [ { "id": "A0A0G2JY13_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JY13", "type": "external" } ], "mass": 7842.0, "length": 69, "protein_name": "A-kinase anchor inhibitor 1", "gene_name": "Akain1", "organism": "Rat", "refseq_name": "A-kinase anchor protein inhibitor 1", "refseq_ac": [ { "id": "NP_001386352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386352", "type": "external" } ], "gene_names_uniprotkb": "Akain1", "gene_names_refseq": "Akain1", "protein_names_uniprotkb": "A-kinase anchor inhibitor 1", "protein_names_refseq": "A kinase (PRKA) anchor inhibitor 1; A-kinase anchor protein inhibitor 1; rCG35631-like", "tax_id": 10116, "disease": "", "pathway": " (rno:100362606)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0031333 negative regulation of protein-containing complex assembly;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JY13-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K010-1", "uniprot_id": [ { "id": "A0A0G2K010_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K010", "type": "external" } ], "mass": 34811.0, "length": 310, "protein_name": "Olfactory receptor", "gene_name": "Or4c115", "organism": "Rat", "refseq_name": "olfactory receptor Olr677", "refseq_ac": [ { "id": "NP_001001062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001062", "type": "external" } ], "gene_names_uniprotkb": "Or4c115", "gene_names_refseq": "Olr677; Or4c115", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 677; olfactory receptor Olr677; olfactory receptor gene Olr677", "tax_id": 10116, "disease": "", "pathway": " (rno:405950)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K010-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K408-1", "uniprot_id": [ { "id": "A0A0G2K408_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K408", "type": "external" } ], "mass": 34967.0, "length": 311, "protein_name": "Olfactory receptor", "gene_name": "Or2ah1", "organism": "Rat", "refseq_name": "olfactory receptor Olr461", "refseq_ac": [ { "id": "NP_001000294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000294", "type": "external" } ], "gene_names_uniprotkb": "Or2ah1", "gene_names_refseq": "Olr461; Or2ah1", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 461; olfactory receptor Olr461; olfactory receptor gene Olr461", "tax_id": 10116, "disease": "", "pathway": " (rno:295730)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K408-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K4T6-1", "uniprot_id": [ { "id": "A0A0G2K4T6_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K4T6", "type": "external" } ], "mass": 44907.0, "length": 416, "protein_name": "NIPA-like domain containing 1", "gene_name": "Nipal1", "organism": "Rat", "refseq_name": "magnesium transporter NIPA3", "refseq_ac": [ { "id": "NP_001388381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388381", "type": "external" } ], "gene_names_uniprotkb": "Nipal1", "gene_names_refseq": "Nipal1; Npal1; RGD1310092", "protein_names_uniprotkb": "NIPA-like domain containing 1", "protein_names_refseq": "magnesium transporter NIPA3", "tax_id": 10116, "disease": "hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (rno:289594); (R-RNO-5223345)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0015693 magnesium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K4T6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K5U3-1", "uniprot_id": [ { "id": "A0A0G2K5U3_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K5U3", "type": "external" } ], "mass": 36926.0, "length": 334, "protein_name": "Endonuclease V", "gene_name": "Endov", "organism": "Rat", "refseq_name": "endonuclease V", "refseq_ac": [ { "id": "NP_001388992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388992", "type": "external" } ], "gene_names_uniprotkb": "Endov", "gene_names_refseq": "Endov", "protein_names_uniprotkb": "Endonuclease V", "protein_names_refseq": "endonuclease V", "tax_id": 10116, "disease": "", "pathway": " (rno:498029)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Active against both single-stranded and double-stranded RNAs. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0003727 single-stranded RNA binding;GO:0016888 DNA endonuclease activity, producing 5'-phosphomonoesters;GO:0016891 RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K5U3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1KQY6-1", "uniprot_id": [ { "id": "A1KQY6_RAT", "url": "https://www.uniprot.org/uniprot/A1KQY6", "type": "external" } ], "mass": 51762.0, "length": 454, "protein_name": "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4", "gene_name": "St8sia4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "St8sia4", "gene_names_refseq": "", "protein_names_uniprotkb": "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:116696); (R-RNO-4085001); (R-RNO-419037)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan protein acceptor through alpha-2,8-linkages. Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides, including NCAM1 N-glycans, FETUB N-glycans and AHSG. It is noteworthy that alpha-2,3-linked sialic acid is apparently a better acceptor than alpha-2,6-linked sialic acid., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MA57", "ec_number_list": [ { "id": "2.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.-", "type": "external" } ], "go_molecular_function": "GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;GO:0008373 sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0009101 glycoprotein biosynthetic process;GO:0009311 oligosaccharide metabolic process;GO:0006491 N-glycan processing;GO:0097503 sialylation", "synthesized_glycan_count": 21, "hit_score": 0.1, "record_id": "A1KQY6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2SY89-1", "uniprot_id": [ { "id": "A2SY89_RAT", "url": "https://www.uniprot.org/uniprot/A2SY89", "type": "external" } ], "mass": 41562.0, "length": 366, "protein_name": "Growth/differentiation factor 3", "gene_name": "Gdf3", "organism": "Rat", "refseq_name": "growth/differentiation factor 3 precursor", "refseq_ac": [ { "id": "NP_001103141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103141", "type": "external" } ], "gene_names_uniprotkb": "Gdf3", "gene_names_refseq": "Gdf3; RGD1564178", "protein_names_uniprotkb": "Growth/differentiation factor 3", "protein_names_refseq": "growth/differentiation factor 3 precursor", "tax_id": 10116, "disease": "isolated microphthalmia 7 (Disease Ontology:DOID:0060838); Klippel-Feil syndrome 3 (Disease Ontology:DOID:0080591)", "pathway": " (rno:500311)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22223106;35477223", "class_list": "", "function": "GDF3 is a potential target of miR-483-3p and is downregulated in low-protein diet rat offspring and low-birth-weight men., [RefSeq, PubMed]; Secreted key regulators (Fgf1, Bmp4, Gdf3) are expressed by PAC1-immunopositive retinal ganglion cells in the postnatal rat retina. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0045605 negative regulation of epidermal cell differentiation;GO:0001701 in utero embryonic development;GO:0007165 signal transduction;GO:0045600 positive regulation of fat cell differentiation;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2SY89-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BN31-1", "uniprot_id": [ { "id": "B0BN31_RAT", "url": "https://www.uniprot.org/uniprot/B0BN31", "type": "external" } ], "mass": 22462.0, "length": 198, "protein_name": "Centrosomal protein 20", "gene_name": "Cep20", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cep20; Fopnl", "gene_names_refseq": "", "protein_names_uniprotkb": "Centrosomal protein 20; FGFR1OP N-terminal-like protein; FOP-related protein of 20 kDa; LisH domain-containing protein FOPNL", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:360461)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the biogenesis of cilia. Required for the recruitment of PLK1 to centrosomes and S phase progression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005813 centrosome;GO:0031514 motile cilium;GO:0005814 centriole;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body", "go_biological_process": "GO:0060271 cilium assembly;GO:0034453 microtubule anchoring", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BN31-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BN66-1", "uniprot_id": [ { "id": "B0BN66_RAT", "url": "https://www.uniprot.org/uniprot/B0BN66", "type": "external" } ], "mass": 42486.0, "length": 387, "protein_name": "Suppressor APC domain containing 2", "gene_name": "Sapcd2", "organism": "Rat", "refseq_name": "suppressor APC domain-containing protein 2", "refseq_ac": [ { "id": "NP_001102888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102888", "type": "external" } ], "gene_names_uniprotkb": "Sapcd2", "gene_names_refseq": "Sapcd2", "protein_names_uniprotkb": "Suppressor APC domain containing 2", "protein_names_refseq": "suppressor APC domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:680531)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0045179 apical cortex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0043296 apical junction complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0000132 establishment of mitotic spindle orientation;GO:0090175 regulation of establishment of planar polarity;GO:0098725 symmetric cell division;GO:1904777 negative regulation of protein localization to cell cortex", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BN66-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BNG5-1", "uniprot_id": [ { "id": "B0BNG5_RAT", "url": "https://www.uniprot.org/uniprot/B0BNG5", "type": "external" } ], "mass": 43360.0, "length": 379, "protein_name": "Hypoxia-inducible factor 1-alpha inhibitor", "gene_name": "Hif1an", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hif1an", "gene_names_refseq": "", "protein_names_uniprotkb": "Hypoxia-inducible factor 1-alpha inhibitor; 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vacuolar protein sorting-associated protein 26B", "tax_id": 10116, "disease": "brain cancer (Disease Ontology:DOID:1319)", "pathway": " (rno:300472)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098837 postsynaptic recycling endosome;GO:0030906 retromer, cargo-selective complex;GO:0005768 endosome;GO:0005769 early endosome", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0071346 cellular response to type II interferon;GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1WBS4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GV41-1", "uniprot_id": [ { "id": "B2GV41_RAT", "url": "https://www.uniprot.org/uniprot/B2GV41", "type": "external" } ], "mass": 65244.0, "length": 564, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 39", "gene_name": "Usp39", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 39 isoform 2", "refseq_ac": [ { "id": "NP_001385670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385670", "type": "external" } ], "gene_names_uniprotkb": "Usp39", "gene_names_refseq": "Usp39", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 39; 3.4.19.12; U4/U6.U5 tri-snRNP-associated 65 kDa protein", "protein_names_refseq": "U4/U6.U5 tri-snRNP-associated protein 2; ubiquitin carboxyl-terminal hydrolase 39 isoform 2; ubiquitin carboxyl-terminal hydrolase 39; ubiquitin specific protease 39", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F7F1N8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0071011 precatalytic spliceosome;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0016579 protein deubiquitination;GO:0051301 cell division;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2GV41-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RYD7-1", "uniprot_id": [ { "id": "B2RYD7_RAT", "url": "https://www.uniprot.org/uniprot/B2RYD7", "type": "external" } ], "mass": 93436.0, "length": 824, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "gene_name": "Stt3b", "organism": "Rat", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B", "refseq_ac": [ { "id": "NP_001164010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164010", "type": "external" } ], "gene_names_uniprotkb": "Stt3b", "gene_names_refseq": "RGD1311563; Stt3b", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B; 2.4.99.18", "protein_names_refseq": "STT3B, catalytic subunit of the oligosaccharyltransferase complex; STT3B, subunit of the oligosaccharyltransferase complex (catalytic); dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B; source of immunodominant MHC-associated peptides", "tax_id": 10116, "disease": "congenital disorder of glycosylation Iw (Disease Ontology:DOID:0080572); congenital disorder of glycosylation Ix (Disease Ontology:DOID:0080573)", "pathway": " (rno:363160); (R-RNO-9931295)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22673903;24090084;38843836", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PTQ6", "ec_number_list": [ { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity", "go_cellular_component": "GO:0008250 oligosaccharyltransferase complex;GO:0005783 endoplasmic reticulum;GO:0032991 protein-containing complex;GO:0160227 oligosaccharyltransferase complex B;GO:0016020 membrane", "go_biological_process": "GO:0043687 post-translational protein modification;GO:0006487 protein N-linked glycosylation;GO:0009101 glycoprotein biosynthetic process;GO:0036503 ERAD pathway;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B2RYD7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RZ79-1", "uniprot_id": [ { "id": "B2RZ79_RAT", "url": "https://www.uniprot.org/uniprot/B2RZ79", "type": "external" } ], "mass": 17967.0, "length": 167, "protein_name": "Iron-sulfur cluster assembly enzyme ISCU", "gene_name": "Iscu", "organism": "Rat", "refseq_name": "iron-sulfur cluster assembly enzyme ISCU", "refseq_ac": [ { "id": "NP_001099406", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099406", "type": "external" } ], "gene_names_uniprotkb": "Iscu", "gene_names_refseq": "Iscu; RGD1309562", "protein_names_uniprotkb": "Iron-sulfur cluster assembly enzyme ISCU; NifU-like N-terminal domain-containing protein; NifU-like protein", "protein_names_refseq": "IscU iron-sulfur cluster scaffold homolog; iron-sulfur cluster assembly enzyme ISCU, mitochondrial; iron-sulfur cluster assembly enzyme ISCU", "tax_id": 10116, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); mitochondrial myopathy (Disease Ontology:DOID:699)", "pathway": " (rno:288740); (R-RNO-1362409); (R-RNO-9854311); (R-RNO-9865881)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "22673903;30656514;32388695", "class_list": "", "function": "MiR-210 by downregulating ISCU and inducing mitochondrial dysfunction in neurons is a potent contributor of oxidative brain injury after neonatal Hypoxic-Ischemia., [RefSeq, PubMed]; MiR-210-3p Inhibits Proliferation and Migration of C6 Cells by Targeting Iscu., [RefSeq, PubMed]; Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0008198 ferrous iron binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0099128 mitochondrial [2Fe-2S] assembly complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006879 intracellular iron ion homeostasis;GO:0044571 [2Fe-2S] cluster assembly;GO:1902958 positive regulation of mitochondrial electron transport, NADH to ubiquinone;GO:1904439 negative regulation of iron ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B2RZ79-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DEG8-1", "uniprot_id": [ { "id": "B5DEG8_RAT", "url": "https://www.uniprot.org/uniprot/B5DEG8", "type": "external" } ], "mass": 118524.0, "length": 1095, "protein_name": "SEC24 homolog C, COPII coat complex component", "gene_name": "Sec24c", "organism": "Rat", "refseq_name": "protein transport protein Sec24C", "refseq_ac": [ { "id": "NP_001102926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102926", "type": "external" } ], "gene_names_uniprotkb": "Sec24c", "gene_names_refseq": "Sec24c", "protein_names_uniprotkb": "SEC24 homolog C, COPII coat complex component", "protein_names_refseq": "SEC24 family, member C; SEC24 homolog C, COPII coat complex component; SEC24 related gene family, member C; protein transport protein Sec24C", "tax_id": 10116, "disease": "", "pathway": " (rno:685144); (R-RNO-204005); (R-RNO-2132295); (R-RNO-5694530); (R-RNO-983170)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "24790205;34502162", "class_list": "", "function": "Axonal delivery of serotonin transporter is contingent on recruitment of SEC24C in the endoplasmic reticulum., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site;GO:0030127 COPII vesicle coat", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0001701 in utero embryonic development;GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B5DEG8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DEM7-1", "uniprot_id": [ { "id": "B5DEM7_RAT", "url": "https://www.uniprot.org/uniprot/B5DEM7", "type": "external" } ], "mass": 17311.0, "length": 153, "protein_name": "SPT4 homolog, DSIF elongation factor subunit", "gene_name": "Supt4h1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Supt4h1", "gene_names_refseq": "", "protein_names_uniprotkb": "SPT4 homolog, DSIF elongation factor subunit", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:287608); (R-RNO-112382); (R-RNO-113418); (R-RNO-674695); (R-RNO-6796648); (R-RNO-6807505); (R-RNO-75955)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046982 protein heterodimerization activity;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0032044 DSIF complex;GO:0005634 nucleus", "go_biological_process": "GO:0032785 negative regulation of DNA-templated transcription, elongation;GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B5DEM7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z956-1", "uniprot_id": [ { "id": "D3Z956_RAT", "url": "https://www.uniprot.org/uniprot/D3Z956", "type": "external" } ], "mass": 36450.0, "length": 317, "protein_name": "Retinaldehyde-binding protein 1", "gene_name": "Rlbp1", "organism": "Rat", "refseq_name": "retinaldehyde-binding protein 1", "refseq_ac": [ { "id": "NP_001099744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099744", "type": "external" } ], "gene_names_uniprotkb": "Rlbp1", "gene_names_refseq": "Rlbp1", "protein_names_uniprotkb": "Retinaldehyde-binding protein 1; Cellular retinaldehyde-binding protein", "protein_names_refseq": "retinaldehyde-binding protein 1", "tax_id": 10116, "disease": "Bothnia retinal dystrophy (Disease Ontology:DOID:0050683); Newfoundland cone-rod dystrophy (Disease Ontology:DOID:0111015); retinitis pigmentosa (Disease Ontology:DOID:10584); fundus albipunctatus (Disease Ontology:DOID:11105); night blindness (Disease Ontology:DOID:8499)", "pathway": " (rno:293049); (R-RNO-2187335); (R-RNO-2453902)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0019841 retinol binding;GO:0005502 11-cis retinal binding", "go_cellular_component": "GO:0005829 cytosol;GO:0044297 cell body", "go_biological_process": "GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3Z956-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z996-1", "uniprot_id": [ { "id": "D3Z996_RAT", "url": "https://www.uniprot.org/uniprot/D3Z996", "type": "external" } ], "mass": 15310.0, "length": 147, "protein_name": "RIKEN cDNA 9030612E09 gene like", "gene_name": "9030612E09Rikl", "organism": "Rat", "refseq_name": "uncharacterized protein LOC688390", "refseq_ac": [ { "id": "NP_001102966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102966", "type": "external" } ], "gene_names_uniprotkb": "9030612E09Rikl; 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uncharacterized protein LOC100362696", "tax_id": 10116, "disease": "", "pathway": " (rno:100362696)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000785 chromatin", "go_biological_process": "GO:0045815 transcription initiation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZB93-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZBP5-1", "uniprot_id": [ { "id": "D3ZBP5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZBP5", "type": "external" } ], "mass": 61046.0, "length": 538, "protein_name": "Flavin-containing monooxygenase", "gene_name": "Fmol", "organism": "Rat", "refseq_name": "flavin-containing monooxygenase 5", "refseq_ac": [ { "id": "XP_008767943", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008767943", "type": "external" } ], "gene_names_uniprotkb": "Fmol; 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Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.14.13.148", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.148", "type": "external" }, { "id": "1.14.13.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.8", "type": "external" }, { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" }, { "id": "1.14.13.32", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.32", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0034899 trimethylamine monooxygenase activity;GO:0050661 NADP binding;GO:0004499 N,N-dimethylaniline monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZBP5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZE36-1", "uniprot_id": [ { "id": "D3ZE36_RAT", "url": "https://www.uniprot.org/uniprot/D3ZE36", "type": "external" } ], "mass": 43215.0, "length": 389, "protein_name": "Hexosyltransferase", "gene_name": "B3gnt8", "organism": "Rat", "refseq_name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8", "refseq_ac": [ { "id": "NP_001100962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100962", "type": "external" } ], "gene_names_uniprotkb": "B3gnt8", "gene_names_refseq": "B3galt7; B3gnt8", "protein_names_uniprotkb": "Hexosyltransferase; 2.4.1.-", "protein_names_refseq": "UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 7; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8", "tax_id": 10116, "disease": "", "pathway": " (rno:308440); (R-RNO-913709)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Beta-1,3-N-acetylglucosaminyltransferase that functions in the elongation of specific branch structures of multiantennary N-glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.206", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.206", "type": "external" } ], "go_molecular_function": "GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity;GO:0016262 protein N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0030311 poly-N-acetyllactosamine biosynthetic process", "synthesized_glycan_count": 1159, "hit_score": 0.1, "record_id": "D3ZE36-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZED9-1", "uniprot_id": [ { "id": "D3ZED9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZED9", "type": "external" } ], "mass": 32932.0, "length": 292, "protein_name": "Leucine rich repeat containing 10B", "gene_name": "Lrrc10b", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 10B", "refseq_ac": [ { "id": "NP_001101047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101047", "type": "external" } ], "gene_names_uniprotkb": "Lrrc10b", "gene_names_refseq": "Lrrc10b; 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May act as a regulator of sperm motility by mediating phosphorylation of sperm doublet microtubule proteins. 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"type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0036126 sperm flagellum;GO:0160110 axonemal microtubule doublet inner sheath", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0030317 flagellated sperm motility;GO:0007286 spermatid development;GO:0018105 peptidyl-serine phosphorylation;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZEK4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZET2-1", "uniprot_id": [ { "id": "D3ZET2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZET2", "type": "external" } ], "mass": 114791.0, "length": 1019, "protein_name": "Serine peptidase inhibitor, Kazal type 5", 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odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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2.4.1.224; Exostosin-L; Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Multiple exostosis-like protein", "protein_names_refseq": "exostoses (multiple)-like 1; exostoses-like 1; exostosin-like 1", "tax_id": 10116, "disease": "hereditary multiple exostoses (Disease Ontology:DOID:206); germ cell cancer (Disease Ontology:DOID:2994)", "pathway": " (rno:313610)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Glycosyltransferase required for the biosynthesis of heparan-sulfate (HS). Transfers N-acetyl-alpha-D-glucosamine to the nascent HS chain (GlcNAcT-II activity). Appears to lack GlcNAcT I and GlcAT-II activities., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.224", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.224", "type": "external" } ], "go_molecular_function": "GO:0008375 acetylglucosaminyltransferase activity;GO:0015020 glucuronosyltransferase activity;GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZLU1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZLZ9-1", "uniprot_id": [ { "id": "D3ZLZ9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZLZ9", "type": "external" } ], "mass": 71727.0, "length": 671, "protein_name": "Trophinin associated protein", "gene_name": "Troap", "organism": "Rat", "refseq_name": "tastin", "refseq_ac": [ { "id": "NP_001258172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258172", "type": "external" } ], "gene_names_uniprotkb": "Troap", "gene_names_refseq": "Troap", "protein_names_uniprotkb": "Trophinin associated protein", "protein_names_refseq": "tastin", "tax_id": 10116, "disease": "", "pathway": " (rno:300219)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZLZ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZMG4-1", "uniprot_id": [ { "id": "D3ZMG4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZMG4", "type": "external" } ], "mass": 54257.0, "length": 476, "protein_name": "Lipase member H", "gene_name": "Lipi", "organism": "Rat", "refseq_name": "lipase member I precursor", "refseq_ac": [ { "id": "NP_001099369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099369", "type": "external" } ], "gene_names_uniprotkb": "Lipi", "gene_names_refseq": "Lipi", "protein_names_uniprotkb": "Lipase member H", "protein_names_refseq": "lipase member I precursor; lipase, member H; lipase, member I", "tax_id": 10116, "disease": "", "pathway": " (rno:288322); (R-RNO-1483166)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0008201 heparin binding;GO:0052689 carboxylic ester hydrolase activity;GO:0004620 phospholipase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0006654 phosphatidic acid biosynthetic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZMG4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZMI7-1", "uniprot_id": [ { "id": "D3ZMI7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZMI7", "type": "external" } ], "mass": 25398.0, "length": 236, "protein_name": "Similar to human chromosome 19 open reading frame 38", "gene_name": "C8h19orf38", "organism": "Rat", "refseq_name": "protein HIDE1", "refseq_ac": [ { "id": "NP_001103094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103094", "type": "external" } ], "gene_names_uniprotkb": "C8h19orf38; LOC691141", "gene_names_refseq": "C8h19orf38", "protein_names_uniprotkb": "Similar to human chromosome 19 open reading frame 38", "protein_names_refseq": "protein HIDE1", "tax_id": 10116, "disease": "", "pathway": " (rno:691141)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZMI7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZNY3-1", "uniprot_id": [ { "id": "D3ZNY3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZNY3", "type": "external" } ], "mass": 46330.0, "length": 415, "protein_name": "Metabolism of cobalamin associated A", "gene_name": "Mmaa", "organism": "Rat", "refseq_name": "methylmalonic aciduria type A protein, mitochondrial", "refseq_ac": [ { "id": "NP_001376190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376190", "type": "external" } ], "gene_names_uniprotkb": "Mmaa", "gene_names_refseq": "Mmaa", "protein_names_uniprotkb": "Metabolism of cobalamin associated A", "protein_names_refseq": "methylmalonic aciduria (cobalamin deficiency) cblA type; methylmalonic aciduria type A protein, mitochondrial", "tax_id": 10116, "disease": "methylmalonic acidemia cblA type (Disease Ontology:DOID:0060742); methylmalonic acidemia (Disease Ontology:DOID:14749)", "pathway": " (rno:291939); (R-RNO-71032); (R-RNO-9759218)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "GTPase, binds and hydrolyzes GTP. Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis. Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT). Plays a dual role as both a protectase and a reactivase for MMUT. Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl). Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0009235 cobalamin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZNY3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A5W3-1", "uniprot_id": [ { "id": "D4A5W3_RAT", "url": "https://www.uniprot.org/uniprot/D4A5W3", "type": "external" } ], "mass": 147435.0, "length": 1327, "protein_name": "Protein naked cuticle homolog", "gene_name": "Nod2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nod2", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein naked cuticle homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "Blau syndrome (Disease Ontology:DOID:0050678); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); gastrointestinal carcinoma (Disease Ontology:DOID:0050922); colitis (Disease Ontology:DOID:0060180); meningococcal meningitis (Disease Ontology:DOID:0080176); graft-versus-host disease (Disease Ontology:DOID:0081267); PFAPA syndrome (Disease Ontology:DOID:0081451); inflammatory bowel disease 1 (Disease Ontology:DOID:0110892); leprosy (Disease Ontology:DOID:1024); lung cancer (Disease Ontology:DOID:1324); Behcet's disease (Disease Ontology:DOID:13241); pulmonary sarcoidosis (Disease Ontology:DOID:13406); breast cancer (Disease Ontology:DOID:1612); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); ovarian cancer (Disease Ontology:DOID:2394); larynx cancer (Disease Ontology:DOID:2596); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); familial Mediterranean fever (Disease Ontology:DOID:2987); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); gastritis (Disease Ontology:DOID:4029); autoimmune disease (Disease Ontology:DOID:417); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); pancreatitis (Disease Ontology:DOID:4989); intestinal disease (Disease Ontology:DOID:5295); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (R-RNO-168638); (R-RNO-450302); (R-RNO-450321); (R-RNO-5689896)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cell autonomous antagonist of the canonical Wnt signaling pathway., [UniProtKB, UniProtKB]; Regulatory part that prevents formation of the Nlrp1a inflammasome: in absence of pathogens and other damage-associated signals, interacts with the C-terminal part of Nlrp1a (NACHT, LRR and PYD domains-containing protein 1a, C-terminus), preventing activation of the Nlrp1a inflammasome. In response to pathogen-associated signals, this part is ubiquitinated by the N-end rule pathway and degraded by the proteasome, releasing the cleaved C-terminal part of the protein, which polymerizes and forms the Nlrp1a inflammasome., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 31, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0097110 scaffold protein binding;GO:0038187 pattern recognition receptor activity;GO:0042834 peptidoglycan binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016323 basolateral plasma membrane;GO:0043025 neuronal cell body;GO:0061702 canonical inflammasome complex", "go_biological_process": "GO:0002221 pattern recognition receptor signaling pathway;GO:0006954 inflammatory response;GO:0035556 intracellular signal transduction;GO:0045087 innate immune response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A5W3-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZW49-1", "uniprot_id": [ { "id": "D3ZW49_RAT", "url": "https://www.uniprot.org/uniprot/D3ZW49", "type": "external" } ], "mass": 22639.0, "length": 199, "protein_name": "TMEM9 domain family, member B", "gene_name": "Ascl3; Tmem9b", "organism": "Rat", "refseq_name": "transmembrane protein 9B isoform 1 precursor", "refseq_ac": [ { "id": "NP_001385672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385672", "type": "external" } ], "gene_names_uniprotkb": "Ascl3; Tmem9b; Tmem9b", "gene_names_refseq": "RGD1310775; Tmem9b", "protein_names_uniprotkb": "TMEM9 domain family, member B", "protein_names_refseq": "transmembrane protein 9B isoform 1 precursor; transmembrane protein 9B", "tax_id": 10116, "disease": "", "pathway": " (rno:246301)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031901 early endosome membrane;GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060429 epithelium development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0001894 tissue homeostasis;GO:0007431 salivary gland development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZW49-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V930-1", "uniprot_id": [ { "id": "G3V930_RAT", "url": "https://www.uniprot.org/uniprot/G3V930", "type": "external" } ], "mass": 35878.0, "length": 317, "protein_name": "E3 ubiquitin-protein ligase NRDP1", "gene_name": "Rnf41", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase NRDP1 isoform 1", "refseq_ac": [ { "id": "NP_001387996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001387996", "type": "external" } ], "gene_names_uniprotkb": "Rnf41", "gene_names_refseq": "Rnf41", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase NRDP1; 2.3.2.27; RING finger protein 41; RING-type E3 ubiquitin transferase NRDP1", "protein_names_refseq": "E3 ubiquitin-protein ligase NRDP1 isoform 1; E3 ubiquitin-protein ligase NRDP1", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (rno:362814); (R-RNO-1358803); (R-RNO-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "27428330;30720051;32200526", "class_list": "", "function": "Nrdp1 serves an important role in regulating the apoptosis induced by cardiopulmonary bypass in vivo and in vitro through regulating ErbB3 and phosphoAKT protein levels., [RefSeq, PubMed]; Pathway network analysis identified myocardial metabolism, DNA replication, and the cell cycle as the most important pathways targeted by Nrdp1., [RefSeq, PubMed]; Role of the Nrdp1 in Brain Injury Induced by Chronic Intermittent Hypoxia in Rats via Regulating the Protein Levels of ErbB3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XIR0", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" } ], "go_molecular_function": "GO:0005135 interleukin-3 receptor binding;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm;GO:0071782 endoplasmic reticulum tubular network", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1901525 negative regulation of mitophagy;GO:0008285 negative regulation of cell population proliferation;GO:0030336 negative regulation of cell migration;GO:2000379 positive regulation of reactive oxygen species metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "G3V930-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GV65-1", "uniprot_id": [ { "id": "B2GV65_RAT", "url": "https://www.uniprot.org/uniprot/B2GV65", "type": "external" } ], "mass": 11430.0, "length": 106, "protein_name": "HIG1 hypoxia inducible domain family, member 2A", "gene_name": "Higd2a", "organism": "Rat", "refseq_name": "HIG1 domain family member 2A, mitochondrial", "refseq_ac": [ { "id": "NP_001099572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099572", "type": "external" } ], "gene_names_uniprotkb": "Higd2a", "gene_names_refseq": "Higd2a; RGD1309691", "protein_names_uniprotkb": "HIG1 hypoxia inducible domain family, member 2A", "protein_names_refseq": "HIG1 domain family member 2A, mitochondrial; HIG1 domain family, member 2A", "tax_id": 10116, "disease": "", "pathway": " (rno:290999)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:1905235 response to quercetin;GO:0097250 mitochondrial respirasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2GV65-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A096MKA9-1", "uniprot_id": [ { "id": "A0A096MKA9_RAT", "url": "https://www.uniprot.org/uniprot/A0A096MKA9", "type": "external" } ], "mass": 94923.0, "length": 827, "protein_name": "Toll-like receptor", "gene_name": "Tlr6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tlr6", "gene_names_refseq": "", "protein_names_uniprotkb": "Toll-like receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "infective endocarditis (Disease Ontology:DOID:0060000); aspergillosis (Disease Ontology:DOID:13564); alcohol use disorder (Disease Ontology:DOID:1574); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); tuberculosis (Disease Ontology:DOID:399); glucose metabolism disease (Disease Ontology:DOID:4194); rhinitis (Disease Ontology:DOID:4483); primary immunodeficiency disease (Disease Ontology:DOID:612); collagen disease (Disease Ontology:DOID:854); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); bacterial pneumonia (Disease Ontology:DOID:874)", "pathway": " (rno:305353); (R-RNO-5686938)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0071723 lipopeptide binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0045121 membrane raft;GO:0035355 Toll-like receptor 2-Toll-like receptor 6 protein complex", "go_biological_process": "GO:0046209 nitric oxide metabolic process;GO:0043032 positive regulation of macrophage activation;GO:0034136 negative regulation of toll-like receptor 2 signaling pathway;GO:0042496 detection of diacyl bacterial lipopeptide;GO:0001774 microglial cell activation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A096MKA9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K1W9-1", "uniprot_id": [ { "id": "A0A0G2K1W9_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K1W9", "type": "external" } ], "mass": 52070.0, "length": 484, "protein_name": "D-lactate dehydrogenase, mitochondrial", "gene_name": "Ldhd", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ldhd", "gene_names_refseq": "", "protein_names_uniprotkb": "D-lactate dehydrogenase, mitochondrial", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-1268020); (R-RNO-9837999)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The mitochondrial D-lactate dehydrogenase is a stereoselective dehydrogenase that targets a wide variety of D-2-hydroxyacids, particularly those with small to moderately sized hydrophobic groups attached to the C2 atom. It includes D-lactate which is generated in small amounts either endogenously through the methylglyoxal metabolism pathway or exogenously via intestinal bacterial activity and dietary intake. The dehydrogenase acts specifically on D-lactate, not on its stereoisomer L-lactate, and prevents the toxic accumulation of D-lactate in the organism. By converting branched-chain D-2-hydroxyacids into branched-chain ketoacids, it may indirectly regulate branched-chain amino acid metabolism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0004458 D-lactate dehydrogenase (cytochrome) activity;GO:0004457 lactate dehydrogenase activity;GO:0008720 D-lactate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:1903457 lactate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K1W9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A1H0-1", "uniprot_id": [ { "id": "D4A1H0_RAT", "url": "https://www.uniprot.org/uniprot/D4A1H0", "type": "external" } ], "mass": 95124.0, "length": 829, "protein_name": "V-type proton ATPase subunit a", "gene_name": "Atp6v0a4", "organism": "Rat", "refseq_name": "V-type proton ATPase 116 kDa subunit a 4", "refseq_ac": [ { "id": "NP_001402767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001402767", "type": "external" } ], "gene_names_uniprotkb": "Atp6v0a4", "gene_names_refseq": "Atp6v0a4", "protein_names_uniprotkb": "V-type proton ATPase subunit a", "protein_names_refseq": "ATPase, H+ transporting, lysosomal V0 subunit A4; ATPase, H+ transporting, lysosomal V0 subunit A; V-type proton ATPase 116 kDa subunit a 4; V-type proton ATPase 116 kDa subunit a", "tax_id": 10116, "disease": "autosomal recessive distal renal tubular acidosis 3 with or without sensorineural hearing loss (Disease Ontology:DOID:0061166); autosomal recessive osteopetrosis 1 (Disease Ontology:DOID:0110942); renal tubular acidosis (Disease Ontology:DOID:14219); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (R-RNO-1222556); (R-RNO-77387); (R-RNO-917977); (R-RNO-983712)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0045177 apical part of cell;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007605 sensory perception of sound;GO:0001503 ossification;GO:0006885 regulation of pH;GO:0097254 renal tubular secretion;GO:0097401 synaptic vesicle lumen acidification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A1H0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ACS2-1", "uniprot_id": [ { "id": "D4ACS2_RAT", "url": "https://www.uniprot.org/uniprot/D4ACS2", "type": "external" } ], "mass": 87175.0, "length": 797, "protein_name": "Zinc finger protein 438", "gene_name": "Zfp438", "organism": "Rat", "refseq_name": "zinc finger protein 438", "refseq_ac": [ { "id": "NP_001100828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100828", "type": "external" } ], "gene_names_uniprotkb": "Zfp438", "gene_names_refseq": "RGD1307214; Zfp438", "protein_names_uniprotkb": "Zinc finger protein 438", "protein_names_refseq": "zinc finger protein 438", "tax_id": 10116, "disease": "", "pathway": " (rno:307024)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16641100", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4ACS2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AE71-1", "uniprot_id": [ { "id": "D4AE71_RAT", "url": "https://www.uniprot.org/uniprot/D4AE71", "type": "external" } ], "mass": 265499.0, "length": 2391, "protein_name": "Chondroitin sulfate proteoglycan 4B", "gene_name": "Cspg4b", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cspg4b; RGD1561161", "gene_names_refseq": "", "protein_names_uniprotkb": "Chondroitin sulfate proteoglycan 4B", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:294747)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AE71-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3W4-1", "uniprot_id": [ { "id": "D4A3W4_RAT", "url": "https://www.uniprot.org/uniprot/D4A3W4", "type": "external" } ], "mass": 30134.0, "length": 270, "protein_name": "Sorting nexin 11", "gene_name": "Snx11", "organism": "Rat", "refseq_name": "sorting nexin-11", "refseq_ac": [ { "id": "NP_001012012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012012", "type": "external" } ], "gene_names_uniprotkb": "Snx11", "gene_names_refseq": "Snx11", "protein_names_uniprotkb": "Sorting nexin 11", "protein_names_refseq": "sorting nexin-11", "tax_id": 10116, "disease": "", "pathway": " (rno:303493)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1901981 phosphatidylinositol phosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016050 vesicle organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A3W4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q861Q1-1", "uniprot_id": [ { "id": "Q861Q1_RAT", "url": "https://www.uniprot.org/uniprot/Q861Q1", "type": "external" } ], "mass": 42082.0, "length": 373, "protein_name": "RT1 class I, locus CE4", "gene_name": "RT1-CE4", "organism": "Rat", "refseq_name": "RT1 class I, locus CE4 precursor", "refseq_ac": [ { "id": "NP_001008842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008842", "type": "external" } ], "gene_names_uniprotkb": "RT1-CE4", "gene_names_refseq": "RT1-C/E4; RT1-CE4", "protein_names_uniprotkb": "RT1 class I, locus CE4", "protein_names_refseq": "MHC class I protein; RT1 class I, locus CE4 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:414783)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PT10", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030670 phagocytic vesicle membrane;GO:0042612 MHC class I protein complex;GO:0098553 lumenal side of endoplasmic reticulum membrane", "go_biological_process": "GO:0006955 immune response;GO:0002474 antigen processing and presentation of peptide antigen via MHC class I", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q861Q1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0K035-1", "uniprot_id": [ { "id": "MTFR2_RAT", "url": "https://www.uniprot.org/uniprot/B0K035", "type": "external" } ], "mass": 40772.0, "length": 373, "protein_name": "Mitochondrial fission regulator 2", "gene_name": "Bclaf1; Mtfr2", "organism": "Rat", "refseq_name": "mitochondrial fission regulator 2", "refseq_ac": [ { "id": "NP_001277039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277039", "type": "external" } ], "gene_names_uniprotkb": "Bclaf1; Mtfr2; Fam54a; Mtfr2", "gene_names_refseq": "Dufd1; Mtfr2", "protein_names_uniprotkb": "Mitochondrial fission regulator 2", "protein_names_refseq": "DUF729 domain containing 1; mitochondrial fission regulator 2; protein FAM54A-like", "tax_id": 10116, "disease": "", "pathway": " (rno:100911069); (rno:293017)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16641100;22673903", "class_list": "", "function": "May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0000266 mitochondrial fission;GO:0009060 aerobic respiration;GO:0043065 positive regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B0K035-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LZF0-1", "uniprot_id": [ { "id": "KLHL2_RAT", "url": "https://www.uniprot.org/uniprot/F1LZF0", "type": "external" } ], "mass": 65983.0, "length": 593, "protein_name": "Kelch-like protein 2", "gene_name": "Klhl2", "organism": "Rat", "refseq_name": "kelch-like protein 2", "refseq_ac": [ { "id": "NP_001406494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001406494", "type": "external" } ], "gene_names_uniprotkb": "Klhl2", "gene_names_refseq": "Klhl2; RGD1564686", "protein_names_uniprotkb": "Kelch-like protein 2; Mayven", "protein_names_refseq": "kelch-like 2, Mayven; kelch-like protein 2; mayven", "tax_id": 10116, "disease": "", "pathway": " (rno:290692); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10397770;15715669;20504342", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, WNK1, WNK3 and WNK4, leading most often to their proteasomal degradation (By similarity). The BCR(KLHL2) complex catalyzes ubiquitination and degradation of NPTXR (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4 (By similarity). Plays a role in the reorganization of the actin cytoskeleton (PubMed:15715669, PubMed:20504342). Promotes growth of cell projections in oligodendrocyte precursors (PubMed:15715669, PubMed:20504342)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0001726 ruffle", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1LZF0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70601-1", "uniprot_id": [ { "id": "LAT_RAT", "url": "https://www.uniprot.org/uniprot/O70601", "type": "external" } ], "mass": 26193.0, "length": 241, "protein_name": "Linker for activation of T-cells family member 1", "gene_name": "Lat", "organism": "Rat", "refseq_name": "linker for activation of T-cells family member 1", "refseq_ac": [ { "id": "NP_110480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110480", "type": "external" } ], "gene_names_uniprotkb": "Lat", "gene_names_refseq": "Lat", "protein_names_uniprotkb": "Linker for activation of T-cells family member 1; 36 kDa phosphotyrosine adapter protein; p36-38; pp36", "protein_names_refseq": "36 kDa phospho-tyrosine adapter protein; 36 kDa phosphotyrosine adapter protein; linker for activation of T-cells family member 1; p36-38; pp36", "tax_id": 10116, "disease": "IgG4-related disease (Disease Ontology:DOID:0080356); immunodeficiency 52 (Disease Ontology:DOID:0111983)", "pathway": " (rno:81511); (R-RNO-114604); (R-RNO-202433); (R-RNO-2424491); (R-RNO-2454202); (R-RNO-2871796); (R-RNO-2871809); (R-RNO-5673001)", "pathway_count": 8, "publication_count": 6, "publication_id_list": "16160011;22673903;23360572;23443658;38263783;9529333", "class_list": "", "function": "Chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family, [RefSeq, PubMed]; Histone hypoacetylation on LAT promoter could inhibit LAT expression and enhanced Th2 differentiation, while trichostatin A, a histone deacetylase inhibitor, promoted LAT expression and inhibited Th2 cytokine production Publication Status: Online-Only, [RefSeq, PubMed]; RNA-Sequencing Analysis and Expression of Lymphocyte-Specific Protein Tyrosine Kinase, Linker for Activation of T Cells, and 70-kDa T-Cell Receptor Zeta-Chain Associated Protein Kinase in Rat Liver Transplant Rejection., [RefSeq, PubMed]; Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0035591 signaling adaptor activity;GO:0030159 signaling receptor complex adaptor activity;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane;GO:0008180 COP9 signalosome;GO:0001772 immunological synapse", "go_biological_process": "GO:0002260 lymphocyte homeostasis;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007229 integrin-mediated signaling pathway;GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O70601-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38718-1", "uniprot_id": [ { "id": "MPC2_RAT", "url": "https://www.uniprot.org/uniprot/P38718", "type": "external" } ], "mass": 14258.0, "length": 127, "protein_name": "Mitochondrial pyruvate carrier 2", "gene_name": "Mpc2", "organism": "Rat", "refseq_name": "mitochondrial pyruvate carrier 2 isoform 1", "refseq_ac": [ { "id": "NP_001071111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071111", "type": "external" } ], "gene_names_uniprotkb": "Mpc2; Brp44", "gene_names_refseq": "Brp44; Mpc2; RGD1563422; SLC54A2", "protein_names_uniprotkb": "Mitochondrial pyruvate carrier 2; Brain protein 44; Protein 0-44", "protein_names_refseq": "brain protein 44; mitochondrial pyruvate carrier 2 isoform 1; protein 0-44; solute carrier family 54 member 2", "tax_id": 10116, "disease": "intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (rno:100359982)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "3022128;35580702;38843836", "class_list": "", "function": "Downregulation of mitochondrial pyruvate carrier 2 aggravates neuronal injury in the cortex following cerebral ischemia in rat., [RefSeq, PubMed]; Mediates the uptake of pyruvate into mitochondria to maintain the balance between glycolysis and oxidative phosphorylation (By similarity). Plays an essential role in cellular metabolism (By similarity)., [UniProtKB, UniProtKB]; Mediates the uptake of pyruvate into mitochondria., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0050833 pyruvate transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0098800 inner mitochondrial membrane protein complex;GO:7770001 mitochondrial pyruvate carrier complex", "go_biological_process": "GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0006086 pyruvate decarboxylation to acetyl-CoA;GO:0006850 pyruvate import into mitochondria", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P38718-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LZ52-1", "uniprot_id": [ { "id": "KLHL3_RAT", "url": "https://www.uniprot.org/uniprot/F1LZ52", "type": "external" } ], "mass": 64845.0, "length": 587, "protein_name": "Kelch-like protein 3", "gene_name": "Klhl3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Klhl3", "gene_names_refseq": "", "protein_names_uniprotkb": "Kelch-like protein 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination and degradation of WNK1 and WNK4, two activators of Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney, thereby regulating NaCl reabsorption. The BCR(KLHL3) complex also mediates ubiquitination and degradation of WNK3 (By similarity). The BCR(KLHL3) complex also mediates ubiquitination of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney, leading to its degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0097602 cullin family protein binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LZ52-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GUZ2-1", "uniprot_id": [ { "id": "SKA3_RAT", "url": "https://www.uniprot.org/uniprot/B2GUZ2", "type": "external" } ], "mass": 46223.0, "length": 418, "protein_name": "SKA complex subunit 3", "gene_name": "Ska3", "organism": "Rat", "refseq_name": "SKA complex subunit 3 isoform 2", "refseq_ac": [ { "id": "NP_001101849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101849", "type": "external" } ], "gene_names_uniprotkb": "Ska3; Rama1", "gene_names_refseq": "RGD1307201; Ska3", "protein_names_uniprotkb": "SKA complex subunit 3; Spindle and kinetochore-associated protein 3", "protein_names_refseq": "SKA complex subunit 3 isoform 2; SKA complex subunit 3; spindle and kinetochore-associated protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:361047)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle. The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules together with MAPRE1, and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces. The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules. The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase. Within the complex, binds microtubules but with a much lower affinity than SKA1. Promotes stability of the polo-like kinase PLK1 protein (By similarity). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6KHD2", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0000776 kinetochore;GO:0005876 spindle microtubule;GO:0072687 meiotic spindle;GO:0072686 mitotic spindle", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051310 metaphase chromosome alignment;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2GUZ2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35485-1", "uniprot_id": [ { "id": "VEGFB_RAT", "url": "https://www.uniprot.org/uniprot/O35485", "type": "external" } ], "mass": 21869.0, "length": 207, "protein_name": "Vascular endothelial growth factor B", "gene_name": "Vegfb", "organism": "Rat", "refseq_name": "vascular endothelial growth factor B isoform 3 precursor", "refseq_ac": [ { "id": "NP_446001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446001", "type": "external" } ], "gene_names_uniprotkb": "Vegfb; Vrf", "gene_names_refseq": "Vegfb", "protein_names_uniprotkb": "Vascular endothelial growth factor B; VEGF-B; VEGF-related factor; VRF", "protein_names_refseq": "VEGF-B; VEGF-related factor; VRF; vascular endothelial growth factor B isoform 3 precursor", "tax_id": 10116, "disease": "retinal vein occlusion (Disease Ontology:DOID:1727); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:89811); (R-RNO-114608); (R-RNO-194313); (R-RNO-195399)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "26262503;26707994;28314760;34732848;34747201", "class_list": "", "function": "Cardiac-specific VEGFB overexpression reduces lipoprotein lipase activity and improves insulin action in rat heart., [RefSeq, PubMed]; Combined inhibition of PGDF and VEGF with sunitinib prevents chronic rejection changes in experimental kidney transplantation., [RefSeq, PubMed]; Data suggest that dietary fatty acids create epigenetic/nutrigenomic changes in methylation levels of CpG island at Vegfb promoter and changes in Vegfb expression in white adipocytes in vivo and in vitro, with particular up-regulation of DNA methylation by linoleic acid; Vegfb promoter methylation levels are closely related to Vegfb gene expression in visceral and subcutaneous adipose tissue., [RefSeq, PubMed]; Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis (By similarity)., [UniProtKB]; LncRNA TINCR improves cardiac hypertrophy by regulating the miR-211-3p-VEGFB-SDF-1alpha-CXCR4 pathway., [RefSeq, PubMed]; Loss of VEGFB and its downstream signaling is an early event following hyperglycemia, is sustained with disease progression, and could explain diabetic cardiomyopathy., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O54881;Q6DGF3", "ec_number_list": [], "go_molecular_function": "GO:0043183 vascular endothelial growth factor receptor 1 binding;GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane;GO:0036454 growth factor complex", "go_biological_process": "GO:0035470 positive regulation of vascular wound healing;GO:0001525 angiogenesis;GO:0007507 heart development;GO:0010629 negative regulation of gene expression;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35485-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55174-1", "uniprot_id": [ { "id": "ZNT4_RAT", "url": "https://www.uniprot.org/uniprot/O55174", "type": "external" } ], "mass": 47702.0, "length": 430, "protein_name": "Probable proton-coupled zinc antiporter SLC30A4", "gene_name": "Slc30a4", "organism": "Rat", "refseq_name": "probable proton-coupled zinc antiporter SLC30A4", "refseq_ac": [ { "id": "NP_742063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742063", "type": "external" } ], "gene_names_uniprotkb": "Slc30a4; Znt4", "gene_names_refseq": "Slc30a4", "protein_names_uniprotkb": "Probable proton-coupled zinc antiporter SLC30A4; Dri 27 protein; Solute carrier family 30 member 4; Zinc transporter 4; ZnT-4", "protein_names_refseq": "Dri 27/ZnT4 protein; dri 27 protein; probable proton-coupled zinc antiporter SLC30A4; solute carrier family 30 (zinc transporter), member 4; zinc transporter 4; znT-4", "tax_id": 10116, "disease": "prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (rno:64469)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10600821;12388418;18289514;22254085", "class_list": "", "function": "Probable proton-coupled zinc ion antiporter mediating zinc import from cytoplasm potentially into the endocytic compartment (By similarity). Controls zinc deposition in milk (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The loss of ZnT4 in airway inflammation contributes to airway epithelium vulnerability in diseases such as asthma., [RefSeq, PubMed]; The upregulation of ZnT1, ZnT2, and ZnT4 was to decrease the cytosolic zinc levels caused by NO after transient occlusion of the CCA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0046872 metal ion binding;GO:0015297 antiporter activity;GO:0008324 monoatomic cation transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0005770 late endosome", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0010043 response to zinc ion;GO:0009636 response to toxic substance;GO:0033189 response to vitamin A", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O55174-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LP90-1", "uniprot_id": [ { "id": "MINK1_RAT", "url": "https://www.uniprot.org/uniprot/F1LP90", "type": "external" } ], "mass": 150382.0, "length": 1336, "protein_name": "Misshapen-like kinase 1", "gene_name": "Mink1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mink1; Map4k6; Mink", "gene_names_refseq": "", "protein_names_uniprotkb": "Misshapen-like kinase 1; 2.7.11.1; GCK family kinase MiNK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Misshapen/NIK-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6", "protein_names_refseq": "", "tax_id": 10116, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (R-RNO-2559580)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18930710;21048137;22673903", "class_list": "", "function": "Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:21048137). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (PubMed:21048137). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (By similarity). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0014069 postsynaptic density;GO:0030424 axon", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0046330 positive regulation of JNK cascade;GO:0070050 neuron cellular homeostasis;GO:0000165 MAPK cascade;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1LP90-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZKB9-1", "uniprot_id": [ { "id": "TSH3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZKB9", "type": "external" } ], "mass": 117463.0, "length": 1072, "protein_name": "Teashirt homolog 3", "gene_name": "Tshz3", "organism": "Rat", "refseq_name": "teashirt homolog 3", "refseq_ac": [ { "id": "NP_001100976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100976", "type": "external" } ], "gene_names_uniprotkb": "Tshz3; Zfp537", "gene_names_refseq": "Tshz3; Zfp537", "protein_names_uniprotkb": "Teashirt homolog 3; Zinc finger protein 537", "protein_names_refseq": "teashirt homolog 3; teashirt zinc finger family member 3; zinc finger protein 537", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (rno:308523)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19343227", "class_list": "", "function": "Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030426 growth cone", "go_biological_process": "GO:0060993 kidney morphogenesis;GO:0050975 sensory perception of touch;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZKB9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54772-1", "uniprot_id": [ { "id": "SMRD2_RAT", "url": "https://www.uniprot.org/uniprot/O54772", "type": "external" } ], "mass": 59128.0, "length": 531, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2", "gene_name": "Smarcd2", "organism": "Rat", "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2", "refseq_ac": [ { "id": "NP_114189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114189", "type": "external" } ], "gene_names_uniprotkb": "Smarcd2; Baf60b", "gene_names_refseq": "BAF60b; Smarcd2", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2; 60 kDa BRG-1/Brm-associated factor subunit B; BAF60B; BRG1-associated factor 60B", "protein_names_refseq": "60 kDa BRG-1/Brm-associated factor subunit B; BRG1-associated factor 60B; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); Coffin-Siris syndrome (Disease Ontology:DOID:1925)", "pathway": " (rno:83833); (R-RNO-3214858); (R-RNO-8939243); (R-RNO-9933939); (R-RNO-9933946); (R-RNO-9933947); (R-RNO-9934037)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "22673903;9427560", "class_list": "", "function": "Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O54771", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006337 nucleosome disassembly;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O54772-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZV31-1", "uniprot_id": [ { "id": "ZCHC4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZV31", "type": "external" } ], "mass": 56027.0, "length": 489, "protein_name": "rRNA N(6)-adenosine-methyltransferase ZCCHC4", "gene_name": "Zcchc4", "organism": "Rat", "refseq_name": "rRNA N(6)-adenosine-methyltransferase ZCCHC4", "refseq_ac": [ { "id": "NP_001388357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388357", "type": "external" } ], "gene_names_uniprotkb": "Zcchc4", "gene_names_refseq": "Zcchc4", "protein_names_uniprotkb": "rRNA N(6)-adenosine-methyltransferase ZCCHC4; 2.1.1.-; Zinc finger CCHC domain-containing protein 4", "protein_names_refseq": "rRNA N(6)-adenosine-methyltransferase ZCCHC4; rRNA N6-adenosine-methyltransferase ZCCHC4; zinc finger CCHC domain-containing protein 4; zinc finger, CCHC domain containing 4", "tax_id": 10116, "disease": "", "pathway": " (rno:360946)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is required for translation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:1904047 S-adenosyl-L-methionine binding;GO:0008988 rRNA (adenine-N6-)-methyltransferase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0031167 rRNA methylation;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZV31-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A229-1", "uniprot_id": [ { "id": "D4A229_RAT", "url": "https://www.uniprot.org/uniprot/D4A229", "type": "external" } ], "mass": 100156.0, "length": 890, "protein_name": "Serine/threonine-protein kinase", "gene_name": "Prkd3", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase D3", "refseq_ac": [ { "id": "NP_001019434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019434", "type": "external" } ], "gene_names_uniprotkb": "Prkd3", "gene_names_refseq": "Prkcn; Prkd3", "protein_names_uniprotkb": "Serine/threonine-protein kinase; 2.7.11.13", "protein_names_refseq": "protein kinase C, nu; serine/threonine-protein kinase D3", "tax_id": 10116, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (rno:313834)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21971046;22673903;27369082", "class_list": "", "function": "PKD3 is a pivotal mediator of the CaN-NFATc1/c3-PKD3-NFATc4 hypertrophic signaling cascade and a potential new drug target for the pathological cardiac hypertrophy, [RefSeq, PubMed]; SiRNA-mediated knockdown of PKD1, PKD2, and PKD3 markedly attenuated YAP nuclear-cytoplasmic shuttling, phosphorylation at Ser(127), and induction of Ctgf and Areg expression in response to GPCR activation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0001525 angiogenesis;GO:0023056 positive regulation of signaling;GO:0010647 positive regulation of cell communication;GO:0035556 intracellular signal transduction;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D4A229-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88808-1", "uniprot_id": [ { "id": "TUB_RAT", "url": "https://www.uniprot.org/uniprot/O88808", "type": "external" } ], "mass": 55318.0, "length": 505, "protein_name": "Tubby protein homolog", "gene_name": "Tub", "organism": "Rat", "refseq_name": "tubby protein homolog", "refseq_ac": [ { "id": "NP_037209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037209", "type": "external" } ], "gene_names_uniprotkb": "Tub", "gene_names_refseq": "Tub", "protein_names_uniprotkb": "Tubby protein homolog", "protein_names_refseq": "tubby bipartite transcription factor; tubby protein homolog", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25609)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19695251;25031889", "class_list": "", "function": "Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z1A2", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0044877 protein-containing complex binding;GO:0120160 intraciliary transport particle A binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0045494 photoreceptor cell maintenance;GO:0060041 retina development in camera-type eye;GO:0042220 response to cocaine;GO:0050766 positive regulation of phagocytosis;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O88808-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M391-1", "uniprot_id": [ { "id": "STING_RAT", "url": "https://www.uniprot.org/uniprot/F1M391", "type": "external" } ], "mass": 42655.0, "length": 379, "protein_name": "Stimulator of interferon genes protein", "gene_name": "Sting1", "organism": "Rat", "refseq_name": "stimulator of interferon genes protein", "refseq_ac": [ { "id": "NP_001102592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102592", "type": "external" } ], "gene_names_uniprotkb": "Sting1; Sting; Tmem173", "gene_names_refseq": "RGD1562552; Sting1; Tmem173; rSTING", "protein_names_uniprotkb": "Stimulator of interferon genes protein; Transmembrane protein 173; rSTING", "protein_names_refseq": "mitochondrial transmembrane protein 173; stimulator of interferon genes protein", "tax_id": 10116, "disease": "STING-associated vasculopathy with onset in infancy (Disease Ontology:DOID:0111457); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526)", "pathway": " (rno:498840); (R-RNO-1834941); (R-RNO-3134975); (R-RNO-3249367); (R-RNO-3270619); (R-RNO-6798695)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "26669264;35926582;36878046;38518595;38725841;39002476", "class_list": "", "function": "Dysfunction of STING Autophagy Degradation in Senescent Nucleus Pulposus Cells Accelerates Intervertebral Disc Degeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:26669264). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (By similarity). Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, cyclic UMP-AMP (2',3'-cUAMP), and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol (By similarity). Upon binding to c-di-GMP, cUAMP or cGAMP, STING1 oligomerizes, translocates from the endoplasmic reticulum and is phosphorylated by TBK1 on the pLxIS motif, leading to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent anti-viral state (PubMed:26669264). Exhibits 2',3' phosphodiester linkage-specific ligand recognition: can bind both 2'-3' linked cGAMP (2'-3'-cGAMP) and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:26669264). The preference for 2'-3'-cGAMP, compared to other linkage isomers is probably due to the ligand itself, which adopts an organized free-ligand conformation that resembles the STING1-bound conformation and pays low energy costs in changing into the active conformation (By similarity). In addition to promote the production of type I interferons, plays a direct role in autophagy (By similarity). Following cGAMP-binding, STING1 buds from the endoplasmic reticulum into COPII vesicles, which then form the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) (By similarity). The ERGIC serves as the membrane source for WIPI2 recruitment and LC3 lipidation, leading to formation of autophagosomes that target cytosolic DNA or DNA viruses for degradation by the lysosome (By similarity). Promotes autophagy by acting as a proton channel that directs proton efflux from the Golgi to facilitate MAP1LC3B/LC3B lipidation (By similarity). The autophagy- and interferon-inducing activities can be uncoupled and autophagy induction is independent of TBK1 phosphorylation (By similarity). Autophagy is also triggered upon infection by bacteria: following c-di-GMP-binding, which is produced by live Gram-positive bacteria, promotes reticulophagy (By similarity). May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons (By similarity). May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) (By similarity). Involved in intercellular immune signaling. Cross-activated by 2',3'-cGAMP previously generated in virus-infected cells, triggers type I interferon signaling in macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response., [UniProtKB, PubMed, UniProtKB, UniProtKB]; GRP78/IRE1 and cGAS/STING pathway crosstalk through CHOP facilitates iodoacetic acid-mediated testosterone decline., [RefSeq, PubMed]; Inhibition of MAGL attenuates Intervertebral Disc Degeneration by Delaying nucleus pulposus senescence through STING., [RefSeq, PubMed]; Pharmacological inhibition of the cGAS-STING signaling pathway suppresses microglial M1-polarization in the spinal cord and attenuates neuropathic pain., [RefSeq, PubMed]; The cGAS-STING pathway promotes endometriosis by up-regulating autophagy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005768 endosome", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0002221 pattern recognition receptor signaling pathway;GO:0000045 autophagosome assembly;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "F1M391-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JPL0-1", "uniprot_id": [ { "id": "ZN382_RAT", "url": "https://www.uniprot.org/uniprot/A0JPL0", "type": "external" } ], "mass": 63563.0, "length": 549, "protein_name": "Zinc finger protein 382", "gene_name": "Zfp382; Znf382", "organism": "Rat", "refseq_name": "zinc finger protein 382 isoform 2", "refseq_ac": [ { "id": "NP_653350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653350", "type": "external" } ], "gene_names_uniprotkb": "Zfp382; Znf382; Zfp382", "gene_names_refseq": "Ks1; Zfp382; Znf382", "protein_names_uniprotkb": "Zinc finger protein 382; KRAB/zinc finger suppressor protein 1; KS1; Multiple zinc finger and krueppel-associated box protein KS1", "protein_names_refseq": "KRAB/zinc finger suppressor protein 1 (KS1); multiple zinc finger and krueppel-associated box protein KS1; zinc finger protein 382 isoform 2", "tax_id": 10116, "disease": "", "pathway": " (rno:246264); (R-RNO-212436); (R-RNO-9843940)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11154279;9835615", "class_list": "", "function": "Functions as a sequence-specific transcriptional repressor., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62977", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0001558 regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0JPL0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23570-1", "uniprot_id": [ { "id": "IRF1_RAT", "url": "https://www.uniprot.org/uniprot/P23570", "type": "external" } ], "mass": 37065.0, "length": 328, "protein_name": "Interferon regulatory factor 1", "gene_name": "Irf1", "organism": "Rat", "refseq_name": "interferon regulatory factor 1", "refseq_ac": [ { "id": "NP_036723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036723", "type": "external" } ], "gene_names_uniprotkb": "Irf1", "gene_names_refseq": "Irf1", "protein_names_uniprotkb": "Interferon regulatory factor 1; IRF-1", "protein_names_refseq": "IRF-1; interferon regulatory factor 1", "tax_id": 10116, "disease": "immunodeficiency 117 (Disease Ontology:DOID:0061083); stomach cancer (Disease Ontology:DOID:10534); allergic conjunctivitis (Disease Ontology:DOID:11204); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); lung cancer (Disease Ontology:DOID:1324); asthma (Disease Ontology:DOID:2841); endometrial adenocarcinoma (Disease Ontology:DOID:2870); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ureteral obstruction (Disease Ontology:DOID:5199); lung disease (Disease Ontology:DOID:850); smallpox (Disease Ontology:DOID:8736)", "pathway": " (rno:24508)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "23042740;2342469;24119616;24743731;26342280;37098476", "class_list": "", "function": "Exosomal IRF1-loaded rat adipose-derived stem cell sheet contributes to wound healing in the diabetic foot ulcers. Publication Status: Online-Only, [RefSeq, PubMed]; IRF-1 protein levels gradually increased after a spinal cord injury. IRF-1 depletion decreases neuronal apoptosis. Erratum:[J Mol Neurosci. 2016 Apr;58(4):532. doi: 10.1007/s12031-016-0718-7. PMID: 27000775], [RefSeq, PubMed]; The Irf-1 overexpression-induced proliferation of VSMCs, the up-regulation of cyclin E/CDK2 and the acceleration of cell cycle progression are associated with ROS/Erk1/2 signaling pathway under high glucose conditions. Publication Status: Online-Only, [RefSeq, PubMed]; These data implicate that sublytic C5b-9 induces the expression of both p300 and IRF-1, as well as p300-dependent IRF-1 acetylation that may contribute to XAF1 gene activation and subsequent glomerular mesangial cells apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; These findings identify HCN1 channels as a novel neural target for type I IFNs providing the possibility to tune neural responses, [RefSeq, PubMed]; Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses (By similarity). Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage (By similarity). Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Has an essential role in IFNG-dependent immunity to mycobacteria (By similarity). Binds to a consensus sequence in gene promoters (By similarity). Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, RIGI, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as GBP2, GBP5 and NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1 (By similarity). Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4 (By similarity). Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53 (By similarity). Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells (By similarity). Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development (By similarity). Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0043374 CD8-positive, alpha-beta T cell differentiation;GO:2000564 regulation of CD8-positive, alpha-beta T cell proliferation;GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P23570-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DEL3-1", "uniprot_id": [ { "id": "TTC17_RAT", "url": "https://www.uniprot.org/uniprot/B5DEL3", "type": "external" } ], "mass": 135721.0, "length": 1198, "protein_name": "Tetratricopeptide repeat protein 17", "gene_name": "Ttc17", "organism": "Rat", "refseq_name": "tetratricopeptide repeat protein 17 precursor", "refseq_ac": [ { "id": "NP_001101222", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101222", "type": "external" } ], "gene_names_uniprotkb": "Ttc17", "gene_names_refseq": "Ttc17", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 17; TPR repeat protein 17", "protein_names_refseq": "TPR repeat protein 17; tetratricopeptide repeat protein 17 precursor; tetratricopeptide repeat protein 17", "tax_id": 10116, "disease": "", "pathway": " (rno:311224)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "24475127;38843836", "class_list": "", "function": "Plays a role in primary ciliogenesis by modulating actin polymerization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MA48", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0005856 cytoskeleton", "go_biological_process": "GO:0030041 actin filament polymerization;GO:0044782 cilium organization;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B5DEL3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12788-1", "uniprot_id": [ { "id": "TRY4_RAT", "url": "https://www.uniprot.org/uniprot/P12788", "type": "external" } ], "mass": 26573.0, "length": 247, "protein_name": "Trypsin-4", "gene_name": "1810009J06Rikl; Try4", "organism": "Rat", "refseq_name": "trypsin-4 precursor", "refseq_ac": [ { "id": "NP_775423", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775423", "type": "external" } ], "gene_names_uniprotkb": "1810009J06Rikl; Try4; LOC286960", "gene_names_refseq": "1810009J06Rikl; P23; Try4", "protein_names_uniprotkb": "Trypsin-4; 3.4.21.4; P23; Pretrypsinogen IV; Trypsin IV", "protein_names_refseq": "preprotrypsinogen IV; pretrypsinogen IV; trypsin IV; trypsin-4 precursor; trypsin-4", "tax_id": 10116, "disease": "", "pathway": " (rno:286960)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2780302", "class_list": "", "function": "Serine protease capable of autoactivation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P12788-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L1L7-1", "uniprot_id": [ { "id": "ZN426_RAT", "url": "https://www.uniprot.org/uniprot/A1L1L7", "type": "external" } ], "mass": 63005.0, "length": 553, "protein_name": "Zinc finger protein 426", "gene_name": "Zfp426; Znf426", "organism": "Rat", "refseq_name": "zinc finger protein 426 isoform 1", "refseq_ac": [ { "id": "NP_001073412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073412", "type": "external" } ], "gene_names_uniprotkb": "Zfp426; Znf426; Zfp426", "gene_names_refseq": "Zfp426; Znf426", "protein_names_uniprotkb": "Zinc finger protein 426", "protein_names_refseq": "zinc finger protein 426 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:690895); (R-RNO-212436)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1L1L7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DEK8-1", "uniprot_id": [ { "id": "VOPP1_RAT", "url": "https://www.uniprot.org/uniprot/B5DEK8", "type": "external" } ], "mass": 19411.0, "length": 172, "protein_name": "WW domain binding protein VOPP1", "gene_name": "Vopp1", "organism": "Rat", "refseq_name": "WW domain binding protein VOPP1 precursor", "refseq_ac": [ { "id": "NP_001102100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102100", "type": "external" } ], "gene_names_uniprotkb": "Vopp1; Ecop", "gene_names_refseq": "Ecop; RGD1306494; Vopp1", "protein_names_uniprotkb": "WW domain binding protein VOPP1; ECop; EGFR-coamplified and overexpressed protein; Vesicular, overexpressed in cancer, prosurvival protein 1", "protein_names_refseq": "EGFR-coamplified and overexpressed protein; VOPP1, WBP1/VOPP1 family member; WW domain binding protein VOPP1 precursor; WW domain binding protein VOPP1; vesicular, overexpressed in cancer, prosurvival protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:362374)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed. May sequester WWOX in lysosomal vesicles and thereby regulate WWOX role as tumor suppressor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005768 endosome;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B5DEK8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M625-1", "uniprot_id": [ { "id": "UBP46_RAT", "url": "https://www.uniprot.org/uniprot/F1M625", "type": "external" } ], "mass": 42415.0, "length": 366, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 46", "gene_name": "Usp46", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 46", "refseq_ac": [ { "id": "NP_001178525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178525", "type": "external" } ], "gene_names_uniprotkb": "Usp46", "gene_names_refseq": "RGD1564808; Usp46", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 46; 3.4.19.12; Deubiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46", "protein_names_refseq": "deubiquitinating enzyme 46; ubiquitin carboxyl-terminal hydrolase 46; ubiquitin specific protease 46; ubiquitin thioesterase 46; ubiquitin-specific-processing protease 46", "tax_id": 10116, "disease": "", "pathway": " (rno:289584)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22043315;26077708", "class_list": "", "function": "Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results suggest that the Lys 92 deletion of USP46 could influence enzyme activity and thereby provide a molecular clue how the enzyme regulating the pathogenesis of mental illnesses., [RefSeq, PubMed]; USP46-mediated regulation of Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor ubiquitination and turnover may play an important role in synaptic plasticity and brain function. Erratum:[J Neurochem. 2017 May;141(3):472. doi: 10.1111/jnc.14023. PMID: 28417468], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G8ACC6", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0048149 behavioral response to ethanol;GO:0008343 adult feeding behavior;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1M625-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1WC15-1", "uniprot_id": [ { "id": "ZCHC7_RAT", "url": "https://www.uniprot.org/uniprot/B1WC15", "type": "external" } ], "mass": 63326.0, "length": 542, "protein_name": "Zinc finger CCHC domain-containing protein 7", "gene_name": "Zcchc7", "organism": "Rat", "refseq_name": "zinc finger CCHC domain-containing protein 7", "refseq_ac": [ { "id": "NP_001100128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100128", "type": "external" } ], "gene_names_uniprotkb": "Zcchc7", "gene_names_refseq": "Zcchc7", "protein_names_uniprotkb": "Zinc finger CCHC domain-containing protein 7; TRAMP-like complex RNA-binding factor ZCCHC7", "protein_names_refseq": "TRAMP-like complex RNA-binding factor ZCCHC7; zinc finger CCHC domain-containing protein 7; zinc finger, CCHC domain containing 7", "tax_id": 10116, "disease": "", "pathway": " (rno:298086)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0031499 TRAMP complex", "go_biological_process": "GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process;GO:0071038 TRAMP-dependent tRNA surveillance pathway;GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process;GO:0071037 nuclear polyadenylation-dependent snRNA catabolic process;GO:0071039 nuclear polyadenylation-dependent CUT catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1WC15-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZJ96-1", "uniprot_id": [ { "id": "UBP28_RAT", "url": "https://www.uniprot.org/uniprot/D3ZJ96", "type": "external" } ], "mass": 122688.0, "length": 1083, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 28", "gene_name": "Usp28", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 28 isoform 7", "refseq_ac": [ { "id": "NP_001101614", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101614", "type": "external" } ], "gene_names_uniprotkb": "Usp28", "gene_names_refseq": "Usp28", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 28; 3.4.19.12; Deubiquitinating enzyme 28; Ubiquitin thioesterase 28; Ubiquitin-specific-processing protease 28", "protein_names_refseq": "deubiquitinating enzyme 28; ubiquitin carboxyl-terminal hydrolase 28 isoform 7; ubiquitin carboxyl-terminal hydrolase 28; ubiquitin specific protease 28; ubiquitin thioesterase 28; ubiquitin thiolesterase 28; ubiquitin-specific-processing protease 28", "tax_id": 10116, "disease": "", "pathway": " (rno:315639); (R-RNO-5689880)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "30149918", "class_list": "", "function": "Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBXW7) complex. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB]; MiR-92b-3p reverse the proliferaton of pulmonary artery smooth muscle cells under hypoxia condition. miR-92b-3p regulate the protein level of USP28., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D2Y8W6", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006281 DNA repair;GO:0008283 cell population proliferation;GO:0016579 protein deubiquitination;GO:0006974 DNA damage response;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZJ96-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08961-1", "uniprot_id": [ { "id": "ZN423_RAT", "url": "https://www.uniprot.org/uniprot/O08961", "type": "external" } ], "mass": 147227.0, "length": 1311, "protein_name": "Zinc finger protein 423", "gene_name": "Zfp423; Znf423", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zfp423; Znf423; Oaz; Zfp423", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 423; Olf1/EBF-associated zinc finger protein; Smad- and Olf-interacting zinc finger protein; rOAZ", "protein_names_refseq": "", "tax_id": 10116, "disease": "nephronophthisis 14 (Disease Ontology:DOID:0111122); Dandy-Walker syndrome (Disease Ontology:DOID:2785); cerebellar disease (Disease Ontology:DOID:2786)", "pathway": " (rno:94188)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "9151733;9774661", "class_list": "", "function": "Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q63681", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway;GO:0007399 nervous system development;GO:0050872 white fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O08961-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZH22-1", "uniprot_id": [ { "id": "SWET1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZH22", "type": "external" } ], "mass": 24694.0, "length": 221, "protein_name": "Sugar transporter SWEET1", "gene_name": "Slc50a1", "organism": "Rat", "refseq_name": "sugar transporter SWEET1 precursor", "refseq_ac": [ { "id": "NP_001099915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099915", "type": "external" } ], "gene_names_uniprotkb": "Slc50a1; Rag1ap1; Rga", "gene_names_refseq": "RGD1308478; Rag1ap1; Slc50a1", "protein_names_uniprotkb": "Sugar transporter SWEET1; RAG1-activating protein 1; Solute carrier family 50 member 1", "protein_names_refseq": "RAG1-activating protein 1; recombination activating gene 1 activating protein 1; solute carrier family 50 (sugar efflux transporter), member 1; solute carrier family 50 (sugar transporter), member 1; sugar transporter SWEET1 precursor; sugar transporter SWEET1", "tax_id": 10116, "disease": "", "pathway": " (rno:295245); (R-RNO-189200)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "14991772", "class_list": "", "function": "Mediates sugar transport across membranes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051119 sugar transmembrane transporter activity;GO:0042947 glucoside transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0008643 carbohydrate transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZH22-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GUX4-1", "uniprot_id": [ { "id": "UBP21_RAT", "url": "https://www.uniprot.org/uniprot/B2GUX4", "type": "external" } ], "mass": 62700.0, "length": 565, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 21", "gene_name": "Usp21", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 21", "refseq_ac": [ { "id": "NP_001121110", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121110", "type": "external" } ], "gene_names_uniprotkb": "Usp21", "gene_names_refseq": "Usp21", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 21; 3.4.19.12; Deubiquitinating enzyme 21; Ubiquitin thioesterase 21; Ubiquitin-specific-processing protease 21", "protein_names_refseq": "deubiquitinating enzyme 21; ubiquitin carboxyl-terminal hydrolase 21; ubiquitin thioesterase 21; ubiquitin thiolesterase 21; ubiquitin-specific protease 21; ubiquitin-specific-processing protease 21", "tax_id": 10116, "disease": "", "pathway": " (rno:688466); (R-RNO-5357786); (R-RNO-5357905); (R-RNO-5357956); (R-RNO-5689880)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "22298430", "class_list": "", "function": "Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Deubiquitinates BAZ2A/TIP5 leading to its stabilization. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB, UniProtKB]; Studies indicate a key role for USP21 in the governance of microtubule- and centrosome-associated physiological processes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" } ], "go_molecular_function": "GO:0019784 deNEDDylase activity;GO:0003713 transcription coactivator activity;GO:0046872 metal ion binding;GO:0008234 cysteine-type peptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031175 neuron projection development;GO:0045815 transcription initiation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2GUX4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A8X0-1", "uniprot_id": [ { "id": "ZBTB4_RAT", "url": "https://www.uniprot.org/uniprot/D4A8X0", "type": "external" } ], "mass": 103210.0, "length": 984, "protein_name": "Zinc finger and BTB domain-containing protein 4", "gene_name": "Zbtb4", "organism": "Rat", "refseq_name": "zinc finger and BTB domain-containing protein 4", "refseq_ac": [ { "id": "NP_001291281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291281", "type": "external" } ], "gene_names_uniprotkb": "Zbtb4", "gene_names_refseq": "Zbtb4", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 4", "protein_names_refseq": "zinc finger and BTB domain-containing protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:287441)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0005694 chromosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A8X0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C6P6-1", "uniprot_id": [ { "id": "TYY2_RAT", "url": "https://www.uniprot.org/uniprot/P0C6P6", "type": "external" } ], "mass": 41805.0, "length": 376, "protein_name": "Transcription factor YY2", "gene_name": "Mbtps2; Yy2", "organism": "Rat", "refseq_name": "transcription factor YY2", "refseq_ac": [ { "id": "NP_001364162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001364162", "type": "external" } ], "gene_names_uniprotkb": "Mbtps2; Yy2; Mbtps2", "gene_names_refseq": "YY-2; Yy2", "protein_names_uniprotkb": "Transcription factor YY2; YY-2; Yin and yang 2", "protein_names_refseq": "Transcription factor YY2-like; Yin and yang 2; transcription factor YY2", "tax_id": 10116, "disease": "X-linked keratosis follicularis spinulosa decalvans (Disease Ontology:DOID:0080754); ichthyosis follicularis-alopecia-photophobia syndrome 1 (Disease Ontology:DOID:0111821); osteogenesis imperfecta type 19 (Disease Ontology:DOID:0111847); X-linked mutilating palmoplantar keratoderma with periorificial keratotic plaques (Disease Ontology:DOID:0112012)", "pathway": " (rno:103690827)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation (By similarity)., [UniProtKB]; Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0031519 PcG protein complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045542 positive regulation of cholesterol biosynthetic process;GO:0031293 membrane protein intracellular domain proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C6P6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35986-1", "uniprot_id": [ { "id": "ZRAB2_RAT", "url": "https://www.uniprot.org/uniprot/O35986", "type": "external" } ], "mass": 37350.0, "length": 330, "protein_name": "Zinc finger Ran-binding domain-containing protein 2", "gene_name": "Zranb2", "organism": "Rat", "refseq_name": "zinc finger Ran-binding domain-containing protein 2", "refseq_ac": [ { "id": "NP_113804", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113804", "type": "external" } ], "gene_names_uniprotkb": "Zranb2; Zfp265; Zis; Znf265", "gene_names_refseq": "Zfp265; Zis; Znf265; Zranb2", "protein_names_uniprotkb": "Zinc finger Ran-binding domain-containing protein 2; Zinc finger protein 265; Zinc finger, splicing", "protein_names_refseq": "zinc finger Ran-binding domain-containing protein 2; zinc finger protein 265; zinc finger, RAN-binding domain containing 2; zinc finger, splicing", "tax_id": 10116, "disease": "", "pathway": " (rno:58821)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16641100;19567205;22673903;9374836", "class_list": "", "function": "Data show that with the help of negative regulators TGF-beta and FasL, the high levels of IL-1alpha and IL-6 expressions were observed in the early stages of the infection, and decreased gradually in the later weeks both in vitro and in vivo., [RefSeq, PubMed]; Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (By similarity). May interfere with constitutive 5'-splice site selection (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1A4C8", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0006396 RNA processing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35986-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVP7-1", "uniprot_id": [ { "id": "ZFY21_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVP7", "type": "external" } ], "mass": 26009.0, "length": 234, "protein_name": "Zinc finger FYVE domain-containing protein 21", "gene_name": "Zfyve21", "organism": "Rat", "refseq_name": "zinc finger FYVE domain-containing protein 21 isoform 1", "refseq_ac": [ { "id": "NP_001386667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386667", "type": "external" } ], "gene_names_uniprotkb": "Zfyve21", "gene_names_refseq": "Zfyve21", "protein_names_uniprotkb": "Zinc finger FYVE domain-containing protein 21", "protein_names_refseq": "zinc finger FYVE domain-containing protein 21 isoform 1; zinc finger FYVE domain-containing protein 21; zinc finger, FYVE domain containing 21", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005768 endosome;GO:0005925 focal adhesion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVP7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20793-1", "uniprot_id": [ { "id": "MAK_RAT", "url": "https://www.uniprot.org/uniprot/P20793", "type": "external" } ], "mass": 69897.0, "length": 622, "protein_name": "Serine/threonine-protein kinase MAK", "gene_name": "Mak", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase MAK", "refseq_ac": [ { "id": "NP_037268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037268", "type": "external" } ], "gene_names_uniprotkb": "Mak", "gene_names_refseq": "Mak", "protein_names_uniprotkb": "Serine/threonine-protein kinase MAK; 2.7.11.1; Male germ cell-associated kinase", "protein_names_refseq": "serine/threonine-protein kinase MAK", "tax_id": 10116, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); arrhythmogenic right ventricular dysplasia 11 (Disease Ontology:DOID:0110082); retinitis pigmentosa 62 (Disease Ontology:DOID:0110380); dilated cardiomyopathy (Disease Ontology:DOID:12930); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (rno:25677)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2183027;8321219", "class_list": "", "function": "Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Could play an important function in spermatogenesis. Phosphorylates FZR1 in a cell cycle-dependent manner (By similarity). Plays a role in the transcriptional coactivation of AR (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V7Y4;Q6AYW0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P20793-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C644-1", "uniprot_id": [ { "id": "VIP1_RAT", "url": "https://www.uniprot.org/uniprot/P0C644", "type": "external" } ], "mass": 159619.0, "length": 1434, "protein_name": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1", "gene_name": "Mfap1a; Ppip5k1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mfap1a; Ppip5k1; Hisppd2a; Mfap1a; Vip1", "gene_names_refseq": "", "protein_names_uniprotkb": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1; 2.7.4.24; Diphosphoinositol pentakisphosphate kinase 1; Histidine acid phosphatase domain-containing protein 2A; InsP6 and PP-IP5 kinase 1; VIP1 homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:311355); (R-RNO-1855167)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16641100;17702752;22673903", "class_list": "", "function": "Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Involved in pre-mRNA splicing as a component of the spliceosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.4.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.24", "type": "external" } ], "go_molecular_function": "GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity;GO:0000828 inositol hexakisphosphate kinase activity;GO:0000832 inositol hexakisphosphate 5-kinase activity;GO:0052723 inositol hexakisphosphate 1-kinase activity;GO:0033857 5-diphosphoinositol pentakisphosphate 1-kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001527 microfibril", "go_biological_process": "GO:0006020 inositol metabolic process;GO:0032958 inositol phosphate biosynthetic process;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0C644-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18292-1", "uniprot_id": [ { "id": "THRB_RAT", "url": "https://www.uniprot.org/uniprot/P18292", "type": "external" } ], "mass": 70412.0, "length": 617, "protein_name": "Prothrombin", "gene_name": "F2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "F2", "gene_names_refseq": "", "protein_names_uniprotkb": "Prothrombin; 3.4.21.5; Coagulation factor II", "protein_names_refseq": "", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); left ventricular failure (Disease Ontology:DOID:0051064); thrombosis (Disease Ontology:DOID:0060903); COVID-19 (Disease Ontology:DOID:0080600); calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652); acquired angioedema (Disease Ontology:DOID:0080941); thrombophilia due to thrombin defect (Disease Ontology:DOID:0111907); sensorineural hearing loss (Disease Ontology:DOID:10003); osteonecrosis (Disease Ontology:DOID:10159); pre-eclampsia (Disease Ontology:DOID:10591); celiac disease (Disease Ontology:DOID:10608); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); disseminated intravascular coagulation (Disease Ontology:DOID:11247); portal vein thrombosis (Disease Ontology:DOID:11695); factor VIII deficiency (Disease Ontology:DOID:12134); Chagas disease (Disease Ontology:DOID:12140); dengue disease (Disease Ontology:DOID:12205); hemophilia B (Disease Ontology:DOID:12259); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); Huntington's disease (Disease Ontology:DOID:12858); carotid stenosis (Disease Ontology:DOID:13001); toxic shock syndrome (Disease Ontology:DOID:14115); hereditary angioedema (Disease Ontology:DOID:14735); urticaria (Disease Ontology:DOID:1555); retinal vein occlusion (Disease Ontology:DOID:1727); hepatitis C (Disease Ontology:DOID:1883); atherosclerosis (Disease Ontology:DOID:1936); autoimmune hepatitis (Disease Ontology:DOID:2048); prothrombin deficiency (Disease Ontology:DOID:2235); leptospirosis (Disease Ontology:DOID:2297); ovarian cancer (Disease Ontology:DOID:2394); thrombophilia (Disease Ontology:DOID:2452); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); familial Mediterranean fever (Disease Ontology:DOID:2987); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); systemic scleroderma (Disease Ontology:DOID:418); hyperglycemia (Disease Ontology:DOID:4195); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); allergic rhinitis (Disease Ontology:DOID:4481); brain edema (Disease Ontology:DOID:4724); liver cirrhosis (Disease Ontology:DOID:5082); eye disease (Disease Ontology:DOID:5614); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); appendicitis (Disease Ontology:DOID:8337); bullous pemphigoid (Disease Ontology:DOID:8506); herpes zoster (Disease Ontology:DOID:8536); ulcerative colitis (Disease Ontology:DOID:8577); bacterial pneumonia (Disease Ontology:DOID:874); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29251); (R-RNO-159740); (R-RNO-159763); (R-RNO-159782); (R-RNO-202733); (R-RNO-375276); (R-RNO-381426); (R-RNO-416476); (R-RNO-456926); (R-RNO-9769733); (R-RNO-9769735); (R-RNO-9769739); (R-RNO-9769743); (R-RNO-977606)", "pathway_count": 14, "publication_count": 5, "publication_id_list": "1373740;1557383;15885490;21454685;2377469", "class_list": "", "function": "Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces (By similarity). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 63, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "4.1.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.90", "type": "external" }, { "id": "3.4.21.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.5", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.4.21.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.6", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0009897 external side of plasma membrane;GO:1905370 serine-type endopeptidase complex", "go_biological_process": "GO:0097068 response to thyroxine;GO:0006508 proteolysis;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P18292-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A6D7-1", "uniprot_id": [ { "id": "TTC19_RAT", "url": "https://www.uniprot.org/uniprot/D4A6D7", "type": "external" } ], "mass": 41333.0, "length": 365, "protein_name": "Tetratricopeptide repeat protein 19, mitochondrial", "gene_name": "Ttc19", "organism": "Rat", "refseq_name": "tetratricopeptide repeat protein 19, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_001103114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103114", "type": "external" } ], "gene_names_uniprotkb": "Ttc19", "gene_names_refseq": "RGD1311797; Ttc19", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 19, mitochondrial; TPR repeat protein 19", "protein_names_refseq": "TPR repeat protein 19; tetratricopeptide repeat protein 19, mitochondrial isoform 2; tetratricopeptide repeat protein 19, mitochondrial", "tax_id": 10116, "disease": "mitochondrial complex III deficiency nuclear type 2 (Disease Ontology:DOID:0060351)", "pathway": " (rno:691506); (R-RNO-9865881)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1. Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation into the complex III and whose presence is detrimental for its catalytic activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D4A3Z0", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0051301 cell division;GO:0022904 respiratory electron transport chain;GO:0034551 mitochondrial respiratory chain complex III assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A6D7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54715-1", "uniprot_id": [ { "id": "VAS1_RAT", "url": "https://www.uniprot.org/uniprot/O54715", "type": "external" } ], "mass": 51123.0, "length": 463, "protein_name": "V-type proton ATPase subunit S1", "gene_name": "Atp6ap1", "organism": "Rat", "refseq_name": "V-type proton ATPase subunit S1 precursor", "refseq_ac": [ { "id": "NP_113973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113973", "type": "external" } ], "gene_names_uniprotkb": "Atp6ap1; Atp6ip1; Atp6s1", "gene_names_refseq": "Atp6ap1; Atp6s1; C7-1", "protein_names_uniprotkb": "V-type proton ATPase subunit S1; C7-1 protein; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; V-ATPase subunit S1; Vacuolar proton pump subunit S1", "protein_names_refseq": "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1; ATPase, H+ transporting, lysosomal accessory protein 1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; V-ATPase subunit S1; V-type proton ATPase subunit S1 precursor; V-type proton ATPase subunit S1; vacuolar proton pump subunit S1", "tax_id": 10116, "disease": "immunodeficiency 47 (Disease Ontology:DOID:0112002)", "pathway": " (rno:83615); (R-RNO-77387); (R-RNO-8980692); (R-RNO-917977); (R-RNO-983712)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "10686355;32165585", "class_list": "", "function": "Accessory subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32165585). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity (By similarity). Involved in membrane trafficking and Ca(2+)-dependent membrane fusion (By similarity). May play a role in the assembly of the V-type ATPase complex (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). In islets of Langerhans cells, may regulate the acidification of dense-core secretory granules (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. In islets of Langerhans cells, may regulate the acidification of dense-core secretory granules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0033176 proton-transporting V-type ATPase complex;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0010008 endosome membrane;GO:0030665 clathrin-coated vesicle membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0036035 osteoclast development;GO:0030641 regulation of cellular pH;GO:0036295 cellular response to increased oxygen levels;GO:0099638 endosome to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O54715-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35757-1", "uniprot_id": [ { "id": "VEGFC_RAT", "url": "https://www.uniprot.org/uniprot/O35757", "type": "external" } ], "mass": 46397.0, "length": 415, "protein_name": "Vascular endothelial growth factor C", "gene_name": "Vegfc", "organism": "Rat", "refseq_name": "vascular endothelial growth factor C precursor", "refseq_ac": [ { "id": "NP_446105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446105", "type": "external" } ], "gene_names_uniprotkb": "Vegfc", "gene_names_refseq": "Vegfc", "protein_names_uniprotkb": "Vascular endothelial growth factor C; Flt4 ligand; Flt4-L; VEGF-C; VRP; Vascular endothelial growth factor-related protein", "protein_names_refseq": "VEGF-C; VRP; flt4 ligand; flt4-L; vascular endothelial growth factor C precursor; vascular endothelial growth factor-related protein", "tax_id": 10116, "disease": "pterygium (Disease Ontology:DOID:0002116); hereditary lymphedema (Disease Ontology:DOID:0050580); hereditary lymphedema ID (Disease Ontology:DOID:0070209); urinary bladder cancer (Disease Ontology:DOID:11054); nephroblastoma (Disease Ontology:DOID:2154); colon adenocarcinoma (Disease Ontology:DOID:234); ovarian cancer (Disease Ontology:DOID:2394); invasive ductal carcinoma (Disease Ontology:DOID:3008); papillary carcinoma (Disease Ontology:DOID:3113); breast carcinoma (Disease Ontology:DOID:3459); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); renal cell carcinoma (Disease Ontology:DOID:4450); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:114111); (R-RNO-114608); (R-RNO-194313); (R-RNO-195399)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10878616;11683876;32170506;34291766;35259773;35817403;38728943", "class_list": "", "function": "Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MiR-27b promotes angiogenesis and skin repair in scalded rats through regulating VEGF-C expression., [RefSeq, PubMed]; MiR-455-3p regulates lymphangiogenesis in silicosis by regulating VEGF-C/VEGFR3., [RefSeq, PubMed]; Presence of Donor Lymph Nodes Within Vascularized Composite Allotransplantation Ameliorates VEGF-C-mediated Lymphangiogenesis and Delays the Onset of Acute Rejection., [RefSeq, PubMed]; The Effect of Vascular Endothelial Growth Factor C and Adipose-Derived Stem Cells on Lymphatic Regeneration in a Rat Vascularized Lymph Node Transfer Model., [RefSeq, PubMed]; Vascular endothelial growth factor-C modulates cortical NMDA receptor activity in cortical lesions of young patients and rat model with focal cortical dysplasia., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q91ZE3", "ec_number_list": [], "go_molecular_function": "GO:0043185 vascular endothelial growth factor receptor 3 binding;GO:0042056 chemoattractant activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0036454 growth factor complex;GO:0005576 extracellular region", "go_biological_process": "GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35757-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04177-1", "uniprot_id": [ { "id": "TY3H_RAT", "url": "https://www.uniprot.org/uniprot/P04177", "type": "external" } ], "mass": 55966.0, "length": 498, "protein_name": "Tyrosine 3-monooxygenase", "gene_name": "Th", "organism": "Rat", "refseq_name": "tyrosine 3-monooxygenase", "refseq_ac": [ { "id": "NP_036872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036872", "type": "external" } ], "gene_names_uniprotkb": "Th", "gene_names_refseq": "The; Th", "protein_names_uniprotkb": "Tyrosine 3-monooxygenase; 1.14.16.2; TH; Tyrosine 3-hydroxylase", "protein_names_refseq": "tyrosine 3-hydroxylase; tyrosine 3-monooxygenase", "tax_id": 10116, "disease": "autosomal recessive Segawa syndrome (Disease Ontology:DOID:0051059); withdrawal disorder (Disease Ontology:DOID:0060001); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); polycystic ovary syndrome (Disease Ontology:DOID:11612); hyperprolactinemia (Disease Ontology:DOID:12700); Parkinson's disease (Disease Ontology:DOID:14330); Machado-Joseph disease (Disease Ontology:DOID:1440); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); brain ischemia (Disease Ontology:DOID:2316); middle cerebral artery infarction (Disease Ontology:DOID:3525); uremia (Disease Ontology:DOID:4676); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:25085); (R-RNO-209905)", "pathway_count": 2, "publication_count": 62, "publication_id_list": "10933781;11207812;11502746;11922614;1345770;1347949;1351851;15447670;15496595;15817718;16626642;1671583;1672315;17010321;17896794;18094067;18096660;19104749;19448984;19558449;19567779;1979980;20037632;21047500;21129429;21392500;21767616;21871514;22242182;22396106;22684282;23153692;23209770;24297323;24324973;24361276;25206324;2570779;25710381;25713330;26562783;26790482;26969276;27405316;27866280;28071709;2857492;28630892;29495426;31279527;32778969;33078695;36122168;36794530;37349999;38128505;38382359;39870381;7722513;9228951;9636040;9753429", "class_list": "", "function": "Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (By similarity). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan but with lower specificity (PubMed:10933781, PubMed:11922614). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; Diabetes Induces Permanent Deleterious Effects in the Olfactory Bulb Associated with Increased Tyrosine Hydroxylase Expression and ERK1/2 Phosphorylation., [RefSeq, PubMed]; Downregulation of microRNA-330-5p induces manic-like behaviors in REM sleep-deprived rats by enhancing tyrosine hydroxylase expression., [RefSeq, PubMed]; Role of Brain Endothelin Receptor Type B (ETB) in the Regulation of Tyrosine Hydroxylase in the Olfactory Bulb of DOCA-Salt Hypertensive Rats., [RefSeq, PubMed]; Tyrosine Hydroxylase Knockdown at the Hypothalamic Supramammillary Nucleus Area Induces Obesity and Glucose Intolerance., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.16.2", "type": "external" } ], "go_molecular_function": "GO:0034617 tetrahydrobiopterin binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0016597 amino acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005790 smooth endoplasmic reticulum;GO:0030424 axon", "go_biological_process": "GO:1904643 response to curcumin;GO:1990384 hyaloid vascular plexus regression;GO:0006585 dopamine biosynthetic process from tyrosine;GO:0006631 fatty acid metabolic process;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 6.5, "record_id": "P04177-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BN28-1", "uniprot_id": [ { "id": "SKA1_RAT", "url": "https://www.uniprot.org/uniprot/B0BN28", "type": "external" } ], "mass": 29421.0, "length": 254, "protein_name": "SKA complex subunit 1", "gene_name": "Ska1", "organism": "Rat", "refseq_name": "SKA complex subunit 1", "refseq_ac": [ { "id": "NP_001099604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099604", "type": "external" } ], "gene_names_uniprotkb": "Ska1", "gene_names_refseq": "RGD1310784; Ska1", "protein_names_uniprotkb": "SKA complex subunit 1; Spindle and kinetochore-associated protein 1", "protein_names_refseq": "SKA complex subunit 1; spindle and kinetochore-associated protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:291441); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "34115425", "class_list": "", "function": "Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle. The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules together with MAPRE1, and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces. The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules. The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase. In the complex, it mediates interactions with microtubules. It also stimulates AURKB/Aurora B catalytic activity (By similarity). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Loc680254 regulates Schwann cell proliferation through Psrc1 and Ska1 as a microRNA sponge following sciatic nerve injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0015630 microtubule cytoskeleton;GO:0000776 kinetochore;GO:0005876 spindle microtubule;GO:0072687 meiotic spindle", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051310 metaphase chromosome alignment;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0BN28-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PTT0-1", "uniprot_id": [ { "id": "ZDH17_RAT", "url": "https://www.uniprot.org/uniprot/E9PTT0", "type": "external" } ], "mass": 71319.0, "length": 622, "protein_name": "Palmitoyltransferase ZDHHC17", "gene_name": "Zdhhc17", "organism": "Rat", "refseq_name": "palmitoyltransferase ZDHHC17", "refseq_ac": [ { "id": "NP_001034429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034429", "type": "external" } ], "gene_names_uniprotkb": "Zdhhc17", "gene_names_refseq": "Zdhhc17", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC17; 2.3.1.-; 2.3.1.225; Acyltransferase ZDHHC17; Zinc finger DHHC domain-containing protein 17", "protein_names_refseq": "acyltransferase ZDHHC17; acyltransferase ZDHHC7; membrane-associated DHHC17 zinc finger protein; palmitoyltransferase ZDHHC17; zinc finger DHHC domain-containing protein 17; zinc finger DHHC-type palmitoyltransferase 17; zinc finger, DHHC domain containing 17; zinc finger, DHHC-type containing 17", "tax_id": 10116, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (rno:366889)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21705657;25253725;26198635", "class_list": "", "function": "Immunohistochemical analysis of pancreatic sections demonstrated that HIP14 is almost exclusively expressed in insulin-positive cells in islets of Langerhans., [RefSeq, PubMed]; Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (By similarity). Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3 (By similarity). Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade (By similarity). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (By similarity). May play a role in Mg(2+) transport (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Palmitoylates CASP6, thereby preventing its dimerization and subsequent activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2TGJ2", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity;GO:0019705 protein-cysteine S-myristoyltransferase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0042734 presynaptic membrane;GO:0030660 Golgi-associated vesicle membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0042953 lipoprotein transport;GO:0070372 regulation of ERK1 and ERK2 cascade;GO:0043067 regulation of programmed cell death;GO:0018345 protein palmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9PTT0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1WBU4-1", "uniprot_id": [ { "id": "ZBT8A_RAT", "url": "https://www.uniprot.org/uniprot/B1WBU4", "type": "external" } ], "mass": 49945.0, "length": 441, "protein_name": "Zinc finger and BTB domain-containing protein 8A", "gene_name": "Zbtb8a", "organism": "Rat", "refseq_name": "zinc finger and BTB domain-containing protein 8A isoform 1", "refseq_ac": [ { "id": "NP_001386079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386079", "type": "external" } ], "gene_names_uniprotkb": "Zbtb8a", "gene_names_refseq": "Zbtb8a; Zbtb8", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 8A", "protein_names_refseq": "zinc finger and BTB domain containing 8; zinc finger and BTB domain-containing protein 8A isoform 1; zinc finger and BTB domain-containing protein 8A", "tax_id": 10116, "disease": "", "pathway": " (rno:313049)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1WBU4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZX38-1", "uniprot_id": [ { "id": "D3ZX38_RAT", "url": "https://www.uniprot.org/uniprot/D3ZX38", "type": "external" } ], "mass": 14256.0, "length": 122, "protein_name": "Prefoldin subunit 1", "gene_name": "Pfdn1", "organism": "Rat", "refseq_name": "prefoldin subunit 1", "refseq_ac": [ { "id": "NP_001101897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101897", "type": "external" } ], "gene_names_uniprotkb": "Pfdn1", "gene_names_refseq": "Pfdn1", "protein_names_uniprotkb": "Prefoldin subunit 1", "protein_names_refseq": "prefoldin 1; prefoldin subunit 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361310)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0001540 amyloid-beta binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005813 centrosome;GO:0016272 prefoldin complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0042113 B cell activation;GO:0030036 actin cytoskeleton organization;GO:0006457 protein folding;GO:0021549 cerebellum development;GO:0021537 telencephalon development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZX38-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A9X7-1", "uniprot_id": [ { "id": "D4A9X7_RAT", "url": "https://www.uniprot.org/uniprot/D4A9X7", "type": "external" } ], "mass": 67197.0, "length": 622, "protein_name": "Hypermethylated in cancer 2 protein", "gene_name": "Hic2", "organism": "Rat", "refseq_name": "hypermethylated in cancer 2 protein", "refseq_ac": [ { "id": "NP_001099332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099332", "type": "external" } ], "gene_names_uniprotkb": "Hic2", "gene_names_refseq": "Hic2", "protein_names_uniprotkb": "Hypermethylated in cancer 2 protein", "protein_names_refseq": "hypermethylated in cancer 2 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:287940)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional repressor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, 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"length": 163, "protein_name": "Serine peptidase inhibitor, Kazal type 10", "gene_name": "Spink10", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Spink10", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine peptidase inhibitor, Kazal type 10", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, 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"https://www.uniprot.org/uniprot/P26376", "type": "external" } ], "mass": 14971.0, "length": 137, "protein_name": "Interferon-induced transmembrane protein 3", "gene_name": "Ifitm2; Ifitm6; ifitm3", "organism": "Rat", "refseq_name": "interferon-induced transmembrane protein 3", "refseq_ac": [ { "id": "NP_001129596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129596", "type": "external" } ], "gene_names_uniprotkb": "Ifitm2; Ifitm6; ifitm3; Ifitm3", "gene_names_refseq": "DSPA2b; Ifitm3; rat8", "protein_names_uniprotkb": "Interferon-induced transmembrane protein 3; DSPA2b; Dispanin subfamily A member 2b", "protein_names_refseq": "dispanin subfamily A member 2b; interferon-induced transmembrane protein 3; interferon-inducible protein", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600)", "pathway": " (rno:114709); (rno:309104); (rno:361673); (R-RNO-198933)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "14766990;1639276;19901966;22363774;28213474;38306778", "class_list": "", "function": "IFITM3 mediates inflammation induced myocardial injury through JAK2/STAT3 signaling pathway., [RefSeq, PubMed]; IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state., [UniProtKB, UniProtKB, UniProtKB]; Ifitm3 is involved in the pathogenesis of glomerulonephritis via promoter hypermethylation that is associated with Ifitm3 repression in the rat strain susceptible to glomerulonephritis., [RefSeq, PubMed]; Recruitment of rat8 to lipid membrane domains is a necessary step in mammary epithelial cell differentiation., [RefSeq, PubMed]; This work has shown for the first time that IFITM3 physically interacts with OPN and reduces OPN mRNA expression, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5DER6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0007507 heart development;GO:0008285 negative regulation of cell population proliferation;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P26376-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZPV2-1", "uniprot_id": [ { "id": "D3ZPV2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZPV2", "type": "external" } ], "mass": 65504.0, "length": 596, "protein_name": "transketolase", "gene_name": "Tktl1", "organism": "Rat", "refseq_name": "transketolase-like protein 1", "refseq_ac": [ { "id": "NP_001103004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103004", "type": "external" } ], "gene_names_uniprotkb": "Tktl1", "gene_names_refseq": "Tktl1", "protein_names_uniprotkb": "transketolase; 2.2.1.1", "protein_names_refseq": "transketolase-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:689374)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030976 thiamine pyrophosphate binding;GO:0004802 transketolase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZPV2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQG0-1", "uniprot_id": [ { "id": "D3ZQG0_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQG0", "type": "external" } ], "mass": 46615.0, "length": 417, "protein_name": "Mitochondrial rRNA methyltransferase 3", "gene_name": "Mrm3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mrm3; 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Or5m3", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 473; olfactory receptor Olr473; olfactory receptor gene Olr473", "tax_id": 10116, "disease": "", "pathway": " (rno:295744)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZQI2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZSA9-1", "uniprot_id": [ { "id": "D3ZSA9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZSA9", "type": "external" } ], "mass": 135199.0, "length": 1230, "protein_name": "Nodal modulator 1", "gene_name": "Nomo1", "organism": "Rat", "refseq_name": "nodal modulator 1 isoform X1", "refseq_ac": [ { "id": "XP_006229170", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006229170", "type": "external" } ], "gene_names_uniprotkb": "Nomo1", "gene_names_refseq": "Nomo1; RGD1305240", "protein_names_uniprotkb": "Nodal modulator 1", "protein_names_refseq": "nodal modulator 1 isoform X1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. 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Publication Status: Online-Only, [RefSeq, PubMed]; Secreted Frizzled-Related Protein 5 Ameliorates Vascular Calcification in a Rat Model of Chronic Kidney Disease through the Wnt/beta-Catenin Pathway., [RefSeq, PubMed]; Sfrp5 reduces markers of cell proliferation, but increases in parallel dose-dependently glucose-stimulated insulin secretion in INS-1E cells Publication Status: Online-Only, [RefSeq, PubMed]; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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RGD1563929", "protein_names_uniprotkb": "NOBOX oogenesis homeobox", "protein_names_refseq": "homeobox protein NOBOX", "tax_id": 10116, "disease": "primary ovarian insufficiency 5 (Disease Ontology:DOID:0080862)", "pathway": " (rno:502759)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001541 ovarian follicle development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZXL8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZZM3-1", "uniprot_id": [ { "id": "D3ZZM3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZZM3", "type": "external" } ], "mass": 83723.0, "length": 740, "protein_name": "Conserved oligomeric Golgi complex subunit 4", "gene_name": "Cog4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cog4", "gene_names_refseq": "", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 4; Component of oligomeric Golgi complex 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital disorder of glycosylation type IIj (Disease Ontology:DOID:0070262); Saul-Wilson syndrome (Disease Ontology:DOID:0111673)", "pathway": " (rno:361407); (R-RNO-6807878); (R-RNO-6811438); (R-RNO-6811440)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0015031 protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0007030 Golgi organization;GO:0000301 retrograde transport, vesicle recycling within Golgi", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZZM3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZZR4-1", "uniprot_id": [ { "id": "D3ZZR4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZZR4", "type": "external" } ], "mass": 68592.0, "length": 617, "protein_name": "Protein fem-1 homolog C", "gene_name": "Fem1c", "organism": "Rat", "refseq_name": "protein fem-1 homolog C", "refseq_ac": [ { "id": "NP_001100402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100402", "type": "external" } ], "gene_names_uniprotkb": "Fem1c", "gene_names_refseq": "Fem1c", "protein_names_uniprotkb": "Protein fem-1 homolog C; FEM1-gamma", "protein_names_refseq": "feminization 1 homolog c; feminization of XX and XO animals 1C; protein fem-1 homolog C", "tax_id": 10116, "disease": "", "pathway": " (rno:302288); (R-RNO-8951664)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1C) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. The CRL2(FEM1C) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. Promotes ubiquitination and degradation of SLBP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZZR4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A098-1", "uniprot_id": [ { "id": "D4A098_RAT", "url": "https://www.uniprot.org/uniprot/D4A098", "type": "external" } ], "mass": 61642.0, "length": 561, "protein_name": "Doublesex and mab-3 related transcription factor 2", "gene_name": "Dmrt2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dmrt2", "gene_names_refseq": "", "protein_names_uniprotkb": "Doublesex and mab-3 related transcription factor 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "azoospermia (Disease Ontology:DOID:14227)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:2000287 positive regulation of myotome development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007548 sex differentiation;GO:0014807 regulation of somitogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A098-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A0E2-1", "uniprot_id": [ { "id": "D4A0E2_RAT", "url": "https://www.uniprot.org/uniprot/D4A0E2", "type": "external" } ], "mass": 34659.0, "length": 312, "protein_name": "Gamma-soluble NSF attachment protein", "gene_name": "Napg", "organism": "Rat", "refseq_name": "gamma-soluble NSF attachment protein isoform 1", "refseq_ac": [ { "id": "NP_001385588", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385588", "type": "external" } ], "gene_names_uniprotkb": "Napg", "gene_names_refseq": "Napg", "protein_names_uniprotkb": "Gamma-soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachment protein gamma", "protein_names_refseq": "N-ethylmaleimide sensitive fusion protein attachment protein gamma; N-ethylmaleimide-sensitive factor attachment protein, gamma; gamma-soluble NSF attachment protein isoform 1; gamma-soluble NSF attachment protein", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-204005); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-6811438); (R-RNO-6811440)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005483 soluble NSF attachment protein activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0031201 SNARE complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A0E2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A0E3-1", "uniprot_id": [ { "id": "D4A0E3_RAT", "url": "https://www.uniprot.org/uniprot/D4A0E3", "type": "external" } ], "mass": 22275.0, "length": 196, "protein_name": "C-type lectin domain family 3, member A", "gene_name": "Clec3a", "organism": "Rat", "refseq_name": "C-type lectin domain family 3 member A precursor", "refseq_ac": [ { "id": "NP_001102369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102369", "type": "external" } ], "gene_names_uniprotkb": "Clec3a", "gene_names_refseq": "Clec3a; Clecsf1", "protein_names_uniprotkb": "C-type lectin domain family 3, member A", "protein_names_refseq": "C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 1 (cartilage-derived); C-type lectin domain family 3 member A precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:365009)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001503 ossification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A0E3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A0X7-1", "uniprot_id": [ { "id": "D4A0X7_RAT", "url": "https://www.uniprot.org/uniprot/D4A0X7", "type": "external" } ], "mass": 23772.0, "length": 220, "protein_name": "LHFPL tetraspan subfamily member 2 protein", "gene_name": "Lhfpl2", "organism": "Rat", "refseq_name": "LHFPL tetraspan subfamily member 2 protein", "refseq_ac": [ { "id": "NP_001099872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099872", "type": "external" } ], "gene_names_uniprotkb": "Lhfpl2", "gene_names_refseq": "Lhfpl2", "protein_names_uniprotkb": "LHFPL tetraspan subfamily member 2 protein; Lipoma HMGIC fusion partner-like 2 protein", "protein_names_refseq": "LHFPL tetraspan subfamily member 2 protein; lipoma HMGIC fusion partner-like 2 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:294643); (R-RNO-114608)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in female and male fertility. Involved in distal reproductive tract development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007338 single fertilization;GO:0046545 development of primary female sexual characteristics;GO:0046546 development of primary male sexual characteristics;GO:1905516 positive regulation of fertilization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A0X7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A249-1", "uniprot_id": [ { "id": "D4A249_RAT", "url": "https://www.uniprot.org/uniprot/D4A249", "type": "external" } ], "mass": 31189.0, "length": 279, "protein_name": "Acyl-coenzyme A thioesterase MBLAC2", "gene_name": "Mblac2", "organism": "Rat", "refseq_name": "acyl-coenzyme A thioesterase MBLAC2", "refseq_ac": [ { "id": "NP_001102404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102404", "type": "external" } ], "gene_names_uniprotkb": "Mblac2", "gene_names_refseq": "Mblac2; 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Tmem72", "protein_names_uniprotkb": "Transmembrane protein 72", "protein_names_refseq": "transmembrane protein 72", "tax_id": 10116, "disease": "", "pathway": " (rno:362424)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031901 early endosome membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A2U6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3G5-1", "uniprot_id": [ { "id": "D4A3G5_RAT", "url": "https://www.uniprot.org/uniprot/D4A3G5", "type": "external" } ], "mass": 35236.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or52e18", "organism": "Rat", "refseq_name": "olfactory receptor Olr178", "refseq_ac": [ { "id": "NP_001000179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000179", "type": "external" } ], "gene_names_uniprotkb": "Or52e18", "gene_names_refseq": "Olr178; Or52e18; ratchr1-162776675-162777613_ORF", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 178; olfactory receptor Olr178; olfactory receptor gene Olr178", "tax_id": 10116, "disease": "", "pathway": " (rno:293325)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A3G5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A585-1", "uniprot_id": [ { "id": "D4A585_RAT", "url": "https://www.uniprot.org/uniprot/D4A585", "type": "external" } ], "mass": 37801.0, "length": 356, "protein_name": "H6 family homeobox 3", "gene_name": "Hmx3", "organism": "Rat", "refseq_name": "homeobox protein HMX3", "refseq_ac": [ { "id": "NP_001099772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099772", "type": "external" } ], "gene_names_uniprotkb": "Hmx3", "gene_names_refseq": "Hmx3; RGD1559927", "protein_names_uniprotkb": "H6 family homeobox 3", "protein_names_refseq": "H6 homeo box 3; homeobox protein HMX3", "tax_id": 10116, "disease": "", "pathway": " (rno:293537)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0042472 inner ear morphogenesis;GO:0050885 neuromuscular process controlling balance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A585-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A742-1", "uniprot_id": [ { "id": "D4A742_RAT", "url": "https://www.uniprot.org/uniprot/D4A742", "type": "external" } ], "mass": 8183.0, "length": 79, "protein_name": "Reactive oxygen species modulator 1", "gene_name": "Romo1", "organism": "Rat", "refseq_name": "reactive oxygen species modulator 1", "refseq_ac": [ { "id": "NP_001182419", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182419", "type": "external" } ], "gene_names_uniprotkb": "Romo1", "gene_names_refseq": "Romo1", "protein_names_uniprotkb": "Reactive oxygen species modulator 1; Protein MGR2 homolog", "protein_names_refseq": "reactive oxygen species modulator 1", "tax_id": 10116, "disease": "ureteral obstruction (Disease Ontology:DOID:5199)", "pathway": " (rno:679572)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "28791399", "class_list": "", "function": "Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage., [UniProtKB, UniProtKB]; Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation., [UniProtKB, UniProtKB]; The expression of ROMO1 induces ROS production and activates the TGFbeta signaling pathway. It may be concluded that ROMO1 helps to provide a molecular basis for improved clinical intervention and prognosis of patients., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008324 monoatomic cation transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0045039 protein insertion into mitochondrial inner membrane;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0098655 monoatomic cation transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A742-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A7F5-1", "uniprot_id": [ { "id": "D4A7F5_RAT", "url": "https://www.uniprot.org/uniprot/D4A7F5", "type": "external" } ], "mass": 69503.0, "length": 607, "protein_name": "Kelch repeat and BTB domain containing 3", "gene_name": "Kbtbd3", "organism": "Rat", "refseq_name": "kelch repeat and BTB domain-containing protein 3", "refseq_ac": [ { "id": "NP_001101591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101591", "type": "external" } ], "gene_names_uniprotkb": "Kbtbd3", "gene_names_refseq": "Kbtbd3", "protein_names_uniprotkb": "Kelch repeat and BTB domain containing 3", "protein_names_refseq": "kelch repeat and BTB (POZ) domain containing 3; kelch repeat and BTB domain-containing protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:315394)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A7F5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A7G8-1", "uniprot_id": [ { "id": "D4A7G8_RAT", "url": "https://www.uniprot.org/uniprot/D4A7G8", "type": "external" } ], "mass": 151385.0, "length": 1368, "protein_name": "Kinesin-like protein KIF24", "gene_name": "Kif24", "organism": "Rat", "refseq_name": "kinesin-like protein KIF24", "refseq_ac": [ { "id": "NP_001418095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001418095", "type": "external" } ], "gene_names_uniprotkb": "Kif24", "gene_names_refseq": "Kif24; RGD1307723", "protein_names_uniprotkb": "Kinesin-like protein KIF24", "protein_names_refseq": "kinesin-like protein KIF24", "tax_id": 10116, "disease": "", "pathway": " (rno:313170); (R-RNO-5620912)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation. Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle. Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005874 microtubule;GO:0005814 centriole;GO:0032991 protein-containing complex", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0060271 cilium assembly;GO:0007018 microtubule-based movement;GO:0007019 microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A7G8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A7S9-1", "uniprot_id": [ { "id": "D4A7S9_RAT", "url": "https://www.uniprot.org/uniprot/D4A7S9", "type": "external" } ], "mass": 64155.0, "length": 579, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "Trim45", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase TRIM45", "refseq_ac": [ { "id": "NP_001099923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099923", "type": "external" } ], "gene_names_uniprotkb": "Trim45", "gene_names_refseq": "Trim45", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM45; tripartite motif protein 45; tripartite motif-containing protein 45", "tax_id": 10116, "disease": "", "pathway": " (rno:295323)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0050728 negative regulation of inflammatory response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0060348 bone development;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A7S9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A8E5-1", "uniprot_id": [ { "id": "D4A8E5_RAT", "url": "https://www.uniprot.org/uniprot/D4A8E5", "type": "external" } ], "mass": 49337.0, "length": 453, "protein_name": "Ankyrin repeat and SOCS box-containing 16", "gene_name": "Asb16", "organism": "Rat", "refseq_name": "ankyrin repeat and SOCS box protein 16", "refseq_ac": [ { "id": "NP_001102518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102518", "type": "external" } ], "gene_names_uniprotkb": "Asb16", "gene_names_refseq": "Asb16; RGD1563878", "protein_names_uniprotkb": "Ankyrin repeat and SOCS box-containing 16", "protein_names_refseq": "ankyrin repeat and SOCS box protein 16", "tax_id": 10116, "disease": "", "pathway": " (rno:498005); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A8E5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A8K9-1", "uniprot_id": [ { "id": "D4A8K9_RAT", "url": "https://www.uniprot.org/uniprot/D4A8K9", "type": "external" } ], "mass": 34986.0, "length": 311, "protein_name": "Olfactory receptor family 10 subfamily D member 1G", "gene_name": "Or10d1g", "organism": "Rat", "refseq_name": "olfactory receptor Olr1273", "refseq_ac": [ { "id": "NP_001000458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000458", "type": "external" } ], "gene_names_uniprotkb": "Or10d1g", "gene_names_refseq": "Olr1273; Or10d1g", "protein_names_uniprotkb": "Olfactory receptor family 10 subfamily D member 1G", "protein_names_refseq": "olfactory receptor 1273; olfactory receptor 149-like; olfactory receptor Olr1273; olfactory receptor gene Olr1273", "tax_id": 10116, "disease": "", "pathway": " (rno:300589)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A8K9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A8N1-1", "uniprot_id": [ { "id": "D4A8N1_RAT", "url": "https://www.uniprot.org/uniprot/D4A8N1", "type": "external" } ], "mass": 29250.0, "length": 260, "protein_name": "Dolichol-phosphate mannosyltransferase subunit 1", "gene_name": "Dpm1", "organism": "Rat", "refseq_name": "dolichol-phosphate mannosyltransferase subunit 1", "refseq_ac": [ { "id": "NP_001100014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100014", "type": "external" } ], "gene_names_uniprotkb": "Dpm1", "gene_names_refseq": "Dpm1", "protein_names_uniprotkb": "Dolichol-phosphate mannosyltransferase subunit 1; 2.4.1.83", "protein_names_refseq": "dolichol-phosphate (beta-D) mannosyltransferase 1; dolichol-phosphate mannosyltransferase subunit 1; dolichyl-phosphate mannosyltransferase 1; dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit", "tax_id": 10116, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Ie (Disease Ontology:DOID:0080557)", "pathway": " (rno:296394); (R-RNO-162699)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.83", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.83", "type": "external" } ], "go_molecular_function": "GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0033185 dolichol-phosphate-mannose synthase complex;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0035269 protein O-linked glycosylation via mannose;GO:0043048 dolichyl monophosphate biosynthetic process;GO:0006506 GPI anchor biosynthetic process;GO:0070482 response to oxygen levels", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D4A8N1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A994-1", "uniprot_id": [ { "id": "D4A994_RAT", "url": "https://www.uniprot.org/uniprot/D4A994", "type": "external" } ], "mass": 111185.0, "length": 993, "protein_name": "ER membrane protein complex subunit 1", "gene_name": "Emc1", "organism": "Rat", "refseq_name": "ER membrane protein complex subunit 1 precursor", "refseq_ac": [ { "id": "NP_001102160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102160", "type": "external" } ], "gene_names_uniprotkb": "Emc1", "gene_names_refseq": "Emc1; 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Chmp4b", "gene_names_refseq": "Chmp4bl1", "protein_names_uniprotkb": "Chromatin modifying protein 4B-like 1", "protein_names_refseq": "chromatin modifying protein 4B-like 1", "tax_id": 10116, "disease": "cataract 31 multiple types (Disease Ontology:DOID:0110265)", "pathway": " (rno:679886); (R-RNO-1632852); (R-RNO-5620971); (R-RNO-917729); (R-RNO-9668328)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0098978 glutamatergic synapse;GO:0005635 nuclear envelope;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0015031 protein transport;GO:0006900 vesicle budding from membrane;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway;GO:0099175 regulation of postsynapse organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A9Z8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AA77-1", "uniprot_id": [ { "id": "D4AA77_RAT", "url": "https://www.uniprot.org/uniprot/D4AA77", "type": "external" } ], "mass": 218816.0, "length": 1996, "protein_name": "Plexin-D1", "gene_name": "Plxnd1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Plxnd1", "gene_names_refseq": "", "protein_names_uniprotkb": "Plexin-D1", "protein_names_refseq": "", "tax_id": 10116, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); 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RGD1311343", "gene_names_refseq": "C10h5orf47; RGD1311343", "protein_names_uniprotkb": "Similar to human chromosome 5 open reading frame 47", "protein_names_refseq": "uncharacterized protein C5orf47 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:360506)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AAX2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AB90-1", "uniprot_id": [ { "id": "D4AB90_RAT", "url": "https://www.uniprot.org/uniprot/D4AB90", "type": "external" } ], "mass": 13301.0, "length": 119, "protein_name": "Cysteine-rich DPF motif domain-containing protein 1", "gene_name": "Cdpf1", "organism": "Rat", "refseq_name": "cysteine-rich DPF motif domain-containing protein 1", "refseq_ac": [ { "id": "NP_001388097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388097", "type": "external" } ], "gene_names_uniprotkb": "Cdpf1; RGD1306001", "gene_names_refseq": "Cdpf1; RGD1306001", "protein_names_uniprotkb": "Cysteine-rich DPF motif domain-containing protein 1", "protein_names_refseq": "cysteine-rich DPF motif domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AB90-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AC62-1", "uniprot_id": [ { "id": "D4AC62_RAT", "url": "https://www.uniprot.org/uniprot/D4AC62", "type": "external" } ], "mass": 34034.0, "length": 295, "protein_name": "Keratin 222", "gene_name": "Krt222", "organism": "Rat", "refseq_name": "keratin-like protein KRT222", "refseq_ac": [ { "id": "NP_001385785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385785", "type": "external" } ], "gene_names_uniprotkb": "Krt222; 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Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060602 branch elongation of an epithelium;GO:0048619 embryonic hindgut morphogenesis;GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis;GO:0006351 DNA-templated transcription;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ACD0-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ACH5-1", "uniprot_id": [ { "id": "D4ACH5_RAT", "url": "https://www.uniprot.org/uniprot/D4ACH5", "type": "external" } ], "mass": 36786.0, "length": 314, "protein_name": "Elongation of very long chain fatty acids protein 4", "gene_name": "Elovl4", "organism": "Rat", "refseq_name": "very long chain fatty acid elongase 4", "refseq_ac": [ { "id": "NP_001178725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178725", "type": "external" } ], "gene_names_uniprotkb": "Elovl4; ELOVL4", "gene_names_refseq": "Elovl4", "protein_names_uniprotkb": "Elongation of very long chain fatty acids protein 4; 2.3.1.199; 3-keto acyl-CoA synthase ELOVL4; ELOVL FA elongase 4; ELOVL fatty acid elongase 4; Very long chain 3-ketoacyl-CoA synthase 4; Very long chain 3-oxoacyl-CoA synthase 4", "protein_names_refseq": "elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4; elongation of very long chain fatty acids protein 4; elongation of very long chain fatty acids-like 4; very long chain fatty acid elongase 4", "tax_id": 10116, "disease": "Stargardt disease (Disease Ontology:DOID:0050817); spinocerebellar ataxia 34 (Disease Ontology:DOID:0050981); corneal dystrophy (Disease Ontology:DOID:2566); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (rno:315851)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34227061;37491316", "class_list": "", "function": "Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development., [UniProtKB, HAMAP]; Synapse-Specific Defects in Synaptic Transmission in the Cerebellum of W246G Mutant ELOVL4 Rats-a Model of Human SCA34., [RefSeq, PubMed]; W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.199", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.199", "type": "external" } ], "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0007623 circadian rhythm;GO:0006636 unsaturated fatty acid biosynthetic process;GO:1990926 short-term synaptic potentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4ACH5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ACU5-1", "uniprot_id": [ { "id": "D4ACU5_RAT", "url": "https://www.uniprot.org/uniprot/D4ACU5", "type": "external" } ], "mass": 38642.0, "length": 349, "protein_name": "NADPH oxidase organizer 1", "gene_name": "Noxo1", "organism": "Rat", "refseq_name": "NADPH oxidase organizer 1", "refseq_ac": [ { "id": "NP_001380927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001380927", "type": "external" } ], "gene_names_uniprotkb": "Noxo1", "gene_names_refseq": "Noxo1", "protein_names_uniprotkb": "NADPH oxidase organizer 1", "protein_names_refseq": "NADPH oxidase organizer 1", "tax_id": 10116, "disease": "", "pathway": " (rno:302976); (R-RNO-5668599); (R-RNO-9013149); (R-RNO-9013423)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0035091 phosphatidylinositol binding;GO:0016176 superoxide-generating NADPH oxidase activator activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0022617 extracellular matrix disassembly;GO:0006801 superoxide metabolic process;GO:0042554 superoxide anion generation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ACU5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ACZ7-1", "uniprot_id": [ { "id": "D4ACZ7_RAT", "url": "https://www.uniprot.org/uniprot/D4ACZ7", "type": "external" } ], "mass": 35186.0, "length": 314, "protein_name": "Olfactory receptor family 52 subfamily S member 6", "gene_name": "Or52s6", "organism": "Rat", "refseq_name": "olfactory receptor Olr95", "refseq_ac": [ { "id": "NP_001001024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001024", "type": "external" } ], "gene_names_uniprotkb": "Or52s6", "gene_names_refseq": "Olr95; Or52s6", "protein_names_uniprotkb": "Olfactory receptor family 52 subfamily S member 6", "protein_names_refseq": "olfactory receptor 95; olfactory receptor Olr95; olfactory receptor gene Olr95", "tax_id": 10116, "disease": "", "pathway": " (rno:405909)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ACZ7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AD33-1", "uniprot_id": [ { "id": "D4AD33_RAT", "url": "https://www.uniprot.org/uniprot/D4AD33", "type": "external" } ], "mass": 14415.0, "length": 119, "protein_name": "RNA guanine-7 methyltransferase activating subunit", "gene_name": "Ramac", "organism": "Rat", "refseq_name": "RNA guanine-N7 methyltransferase activating subunit", "refseq_ac": [ { "id": "NP_001120923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120923", "type": "external" } ], "gene_names_uniprotkb": "Ramac; Fam103a1; Rammet", "gene_names_refseq": "Fam103a1; RGD1310022; Ramac; Rammet", "protein_names_uniprotkb": "RNA guanine-7 methyltransferase activating subunit", "protein_names_refseq": "RNA guanine-N7 methyltransferase activating subunit; RNMT activating mRNA cap methyltransferase subunit; family with sequence similarity 103, member A1", "tax_id": 10116, "disease": "", "pathway": " (rno:293058)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008047 enzyme activator activity;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031533 mRNA capping enzyme complex;GO:0034708 methyltransferase complex;GO:0160130 mRNA cap methyltransferase RNMT:RAMAC complex", "go_biological_process": "GO:0006370 7-methylguanosine mRNA capping;GO:0106005 RNA 5'-cap (guanine-N7)-methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4AD33-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ADB4-1", "uniprot_id": [ { "id": "D4ADB4_RAT", "url": "https://www.uniprot.org/uniprot/D4ADB4", "type": "external" } ], "mass": 18820.0, "length": 167, "protein_name": "CGG triplet repeat binding protein 1", "gene_name": "Cggbp1", "organism": "Rat", "refseq_name": "CGG triplet repeat-binding protein 1", "refseq_ac": [ { "id": "NP_001099370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099370", "type": "external" } ], "gene_names_uniprotkb": "Cggbp1", "gene_names_refseq": "Cggbp1", "protein_names_uniprotkb": "CGG triplet repeat binding protein 1", "protein_names_refseq": "CGG triplet repeat-binding protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:288353)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003690 double-stranded DNA binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0010468 regulation of gene expression;GO:0040029 epigenetic regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ADB4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ADS9-1", "uniprot_id": [ { "id": "D4ADS9_RAT", "url": "https://www.uniprot.org/uniprot/D4ADS9", "type": "external" } ], "mass": 92524.0, "length": 819, "protein_name": "Protein EFR3 homolog A", "gene_name": "Efr3a", "organism": "Rat", "refseq_name": "protein EFR3 homolog A", "refseq_ac": [ { "id": "NP_001124036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124036", "type": "external" } ], "gene_names_uniprotkb": "Efr3a", "gene_names_refseq": "Efr3a; RGD1305976", "protein_names_uniprotkb": "Protein EFR3 homolog A; Protein EFR3-like", "protein_names_refseq": "protein EFR3 homolog A", "tax_id": 10116, "disease": "", "pathway": " (rno:362923)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16641100;22673903;29393594", "class_list": "", "function": "Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3A probably acts as the membrane-anchoring component. Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0098793 presynapse", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0016082 synaptic vesicle priming", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D4ADS9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ADT4-1", "uniprot_id": [ { "id": "D4ADT4_RAT", "url": "https://www.uniprot.org/uniprot/D4ADT4", "type": "external" } ], "mass": 51365.0, "length": 464, "protein_name": 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Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0030620 U2 snRNA binding;GO:0008237 metallopeptidase activity;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding;GO:0030619 U1 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0071222 cellular response to lipopolysaccharide;GO:0071356 cellular response to tumor necrosis factor;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V6H2-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V6L6-1", "uniprot_id": [ { "id": "G3V6L6_RAT", "url": "https://www.uniprot.org/uniprot/G3V6L6", "type": "external" } ], "mass": 41633.0, "length": 364, "protein_name": "Epiphycan", "gene_name": "Epyc", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Epyc", "gene_names_refseq": "", "protein_names_uniprotkb": "Epiphycan", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:314772)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0007605 sensory perception of sound;GO:0060348 bone development;GO:0061975 articular cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V6L6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V6P0-1", "uniprot_id": [ { "id": "G3V6P0_RAT", "url": "https://www.uniprot.org/uniprot/G3V6P0", "type": "external" } ], "mass": 34546.0, "length": 310, "protein_name": "Olfactory receptor", "gene_name": "Or2a7", "organism": "Rat", "refseq_name": "olfactory receptor Olr818", "refseq_ac": [ { "id": "NP_001000844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000844", "type": "external" } ], "gene_names_uniprotkb": "Or2a7", "gene_names_refseq": "Olr818; Or2a7", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "odorant receptor; olfactory receptor 818; olfactory receptor Olr818; olfactory receptor gene Olr818", "tax_id": 10116, "disease": "", "pathway": " (rno:405133)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V6P0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V784-1", "uniprot_id": [ { "id": "G3V784_RAT", "url": "https://www.uniprot.org/uniprot/G3V784", "type": "external" } ], "mass": 53919.0, "length": 496, "protein_name": "ADP-dependent glucokinase", "gene_name": "Adpgk", "organism": "Rat", "refseq_name": "ADP-dependent glucokinase precursor", "refseq_ac": [ { "id": "NP_001094193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094193", "type": "external" } ], "gene_names_uniprotkb": "Adpgk", "gene_names_refseq": "Adpgk; RGD1306103", "protein_names_uniprotkb": "ADP-dependent glucokinase; 2.7.1.147", "protein_names_refseq": "ADP-dependent glucokinase precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:315722); (R-RNO-70171)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.147", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.147", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0043843 ADP-specific glucokinase activity;GO:0016301 kinase activity;GO:0016773 phosphotransferase activity, alcohol group as acceptor", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V784-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7M2-1", "uniprot_id": [ { "id": "G3V7M2_RAT", "url": "https://www.uniprot.org/uniprot/G3V7M2", "type": "external" } ], "mass": 87629.0, "length": 807, "protein_name": "Integrin beta", "gene_name": "Itgb7", "organism": "Rat", "refseq_name": "integrin beta-7 precursor", "refseq_ac": [ { "id": "NP_037303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037303", "type": "external" } ], "gene_names_uniprotkb": "Itgb7", "gene_names_refseq": "Itgb7", "protein_names_uniprotkb": "Integrin beta", "protein_names_refseq": "integrin beta-7 precursor; integrin, beta 7", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:25713); (R-RNO-198933); (R-RNO-216083)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "35042191", "class_list": "", "function": "Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin ITGA4/ITGB7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Also interacts with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involve the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Integrin ITGAE/ITGB7 (alpha-E/beta-7, HML-1) is a receptor for E-cadherin., [UniProtKB, UniProtKB]; Integrin alphaEbeta7 is involved in the intestinal barrier injury of sepsis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0046872 metal ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0008305 integrin complex;GO:0034669 integrin alpha4-beta7 complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0045785 positive regulation of cell adhesion;GO:0007160 cell-matrix adhesion;GO:0033627 cell adhesion mediated by integrin;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V7M2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7V3-1", "uniprot_id": [ { "id": "G3V7V3_RAT", "url": "https://www.uniprot.org/uniprot/G3V7V3", "type": "external" } ], "mass": 72188.0, "length": 643, "protein_name": "Arachidonate--CoA ligase", "gene_name": "Slc27a4", "organism": "Rat", "refseq_name": "long-chain fatty acid transport protein 4", "refseq_ac": [ { "id": "NP_001094176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094176", "type": "external" } ], "gene_names_uniprotkb": "Slc27a4", "gene_names_refseq": "Fatp4; Slc27a4", "protein_names_uniprotkb": "Arachidonate--CoA ligase; 6.2.1.15; 6.2.1.3; Long-chain-fatty-acid--CoA ligase", "protein_names_refseq": "fatty acid transport protein 4; long-chain fatty acid transport protein 4; solute carrier family 27 (fatty acid transporter), member 4", "tax_id": 10116, "disease": "restrictive dermopathy (Disease Ontology:DOID:0060762); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:311839); (R-RNO-804914)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22673903;36360622;38843836", "class_list": "", "function": "Vitamin D and Swimming Exercise Prevent Obesity in Rats under a High-Fat Diet via Targeting FATP4 and TLR4 in the Liver and Adipose Tissue. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.76", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0000166 nucleotide binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0031957 very long-chain fatty acid-CoA ligase activity;GO:0047676 arachidonate-CoA ligase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031526 brush border membrane;GO:0005902 microvillus", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:1990379 lipid transport across blood-brain barrier;GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "G3V7V3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7Y0-1", "uniprot_id": [ { "id": "G3V7Y0_RAT", "url": "https://www.uniprot.org/uniprot/G3V7Y0", "type": "external" } ], "mass": 43598.0, "length": 396, "protein_name": "Hedgehog protein", "gene_name": "Dhh", "organism": "Rat", "refseq_name": "desert hedgehog protein precursor", "refseq_ac": [ { "id": "NP_445819", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445819", "type": "external" } ], "gene_names_uniprotkb": "Dhh", "gene_names_refseq": "Dhh", "protein_names_uniprotkb": "Hedgehog protein", "protein_names_refseq": "desert hedgehog protein precursor", "tax_id": 10116, "disease": "primary bacterial infectious disease (Disease Ontology:DOID:0050338); 46,XY gonadal dysgenesis with minifascicular neuropathy (Disease Ontology:DOID:0051055); 46,XY sex reversal 7 (Disease Ontology:DOID:0111774); 46,XY complete gonadal dysgenesis (Disease Ontology:DOID:14448)", "pathway": " (rno:84380); (R-RNO-5358346); (R-RNO-5362798); (R-RNO-5632681)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "21062903;21893610;30266964;31949236", "class_list": "", "function": "A missense mutation of the Dhh gene is associated with male pseudohermaphroditic rats showing impaired Leydig cell development., [RefSeq, PubMed]; Dhh and Gli1 might function in concert to regenerate adrenocortical autografts. This is the first report to clearly show Dhh expression and its elevation in the adrenal gland. Publication Status: Online-Only, [RefSeq, PubMed]; GATA4/6 regulate DHH transcription in rat adrenocortical autografts. Publication Status: Online-Only, [RefSeq, PubMed]; Hh signalling is part of the paracrine signalling network in the rat testis. It promotes the survival of germ cells and is suppressed by FSH., [RefSeq, PubMed]; The C-terminal part of the desert hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein into two parts (N-product and C-product) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (DHH-N). Both activities occur in the endoplasmic reticulum. Once cleaved, the C-product is degraded in the endoplasmic reticulum. Functions in cell-cell mediated juxtacrine signaling. Promotes endothelium integrity. Binds to PTCH1 receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes in endothelial cells. In Schwann cells, controls the development of the peripheral nerve sheath and the transition of mesenchymal cells to form the epithelium-like structure of the perineurial tube., [UniProtKB, UniProtKB]; The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product., [UniProtKB, UniProtKB]; The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0016740 transferase activity;GO:0008233 peptidase activity;GO:0005113 patched binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001708 cell fate specification;GO:0045880 positive regulation of smoothened signaling pathway;GO:0007267 cell-cell signaling;GO:0042552 myelination;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "G3V7Y0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7Z1-1", "uniprot_id": [ { "id": "G3V7Z1_RAT", "url": "https://www.uniprot.org/uniprot/G3V7Z1", "type": "external" } ], "mass": 40811.0, "length": 373, "protein_name": "RNA 3'-terminal phosphate cyclase-like protein", "gene_name": "Rcl1", "organism": "Rat", "refseq_name": "RNA 3'-terminal phosphate cyclase-like protein isoform 1", "refseq_ac": [ { "id": "NP_001386385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386385", "type": "external" } ], "gene_names_uniprotkb": "Rcl1", "gene_names_refseq": "Ab1-353; Ac1292; Rcl1", "protein_names_uniprotkb": "RNA 3'-terminal phosphate cyclase-like protein", "protein_names_refseq": "RNA 3'-terminal phosphate cyclase-like protein isoform 1; RNA 3'-terminal phosphate cyclase-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:309301); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "As part of the small subunit (SSU) processome, it plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA. Activates BMS1 by promoting GDP/GTP exchange. Does not have cyclase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BJN0", "ec_number_list": [], "go_molecular_function": "GO:0004521 RNA endonuclease activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis;GO:0006396 RNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V7Z1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V819-1", "uniprot_id": [ { "id": "G3V819_RAT", "url": "https://www.uniprot.org/uniprot/G3V819", "type": "external" } ], "mass": 39235.0, "length": 354, "protein_name": "Protein Wnt", "gene_name": "Wnt11", "organism": "Rat", "refseq_name": "protein Wnt-11", "refseq_ac": [ { "id": "NP_536326", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536326", "type": "external" } ], "gene_names_uniprotkb": "Wnt11", "gene_names_refseq": "Wnt11", "protein_names_uniprotkb": "Protein Wnt", "protein_names_refseq": "protein Wnt-11; wingless-related MMTV integration site 11; wingless-type MMTV integration site family, member 11", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (rno:140584); (R-RNO-3238698); (R-RNO-4086398); (R-RNO-4086400)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "24474615;26193266;33137935", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB]; The pathogenesis of calcium stone development may be associated with synergic effects of TGF-beta1 and Ca2+, which promote epithelial to mesenchymal transition and osteochondral differentiation via Wnt11 and the L-type calcium channel. Publication Status: Online-Only, [RefSeq, PubMed]; WNT11-Conditioned Medium Promotes Angiogenesis through the Activation of Non-Canonical WNT-PKC-JNK Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Wnt11 overexpression promoted chondrogenic differentiation of MSCs in synergism with TGF-beta, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0030295 protein kinase activator activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix", "go_biological_process": "GO:0048341 paraxial mesoderm formation;GO:0048570 notochord morphogenesis;GO:0007165 signal transduction;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "G3V819-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V857-1", "uniprot_id": [ { "id": "G3V857_RAT", "url": "https://www.uniprot.org/uniprot/G3V857", "type": "external" } ], "mass": 31598.0, "length": 285, "protein_name": "Growth arrest-specific protein 2", "gene_name": "Gas2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gas2", "gene_names_refseq": "", "protein_names_uniprotkb": "Growth arrest-specific protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 125 (Disease Ontology:DOID:0061124); sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (rno:499156); (R-RNO-264870)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "GO:0001547 antral ovarian follicle growth;GO:0001544 initiation of primordial ovarian follicle growth;GO:0051764 actin crosslink formation;GO:0030728 ovulation;GO:0071711 basement membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V857-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V862-1", "uniprot_id": [ { "id": "G3V862_RAT", "url": "https://www.uniprot.org/uniprot/G3V862", "type": "external" } ], "mass": 57073.0, "length": 493, "protein_name": "Angiopoietin-like 2", "gene_name": "Angptl2", "organism": "Rat", "refseq_name": "angiopoietin-related protein 2 precursor", "refseq_ac": [ { "id": "NP_598253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598253", "type": "external" } ], "gene_names_uniprotkb": "Angptl2", "gene_names_refseq": "Angptl2", "protein_names_uniprotkb": "Angiopoietin-like 2", "protein_names_refseq": "angiopoietin-related protein 2 precursor; angiopoietin-related protein 2", "tax_id": 10116, "disease": "dermatomyositis (Disease Ontology:DOID:10223)", "pathway": " (rno:171100)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25270312;28946139;32988397;34860608", "class_list": "", "function": "ANGPTL2 knockdown ameliorates Diabetic Nephropathy by inhibiting TLR4 expression, an observation contributing to a better understanding of Diabetic Nephropathy pathogenesis., [RefSeq, PubMed]; Angptl2 gene knockdown is critical for abolishing angiotensin II-induced vascular smooth muscle cell proliferation and migration., [RefSeq, PubMed]; Data indicate that AT1 receptor-associated protein 1 (Arap1) were decreased during heatstroke (HS)., [RefSeq, PubMed]; Expression of angiopoietin-like protein 2 in ovarian tissue of rat polycystic ovarian syndrome model and its correlation study. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "G3V862-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V8X0-1", "uniprot_id": [ { "id": "G3V8X0_RAT", "url": "https://www.uniprot.org/uniprot/G3V8X0", "type": "external" } ], "mass": 34227.0, "length": 307, "protein_name": "Olfactory receptor", "gene_name": "Or4b1c", "organism": "Rat", "refseq_name": "olfactory receptor Olr744", "refseq_ac": [ { "id": "NP_001000577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000577", "type": "external" } ], "gene_names_uniprotkb": "Or4b1c", "gene_names_refseq": "Olr744; Or4b1c", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "odorant receptor; olfactory receptor 744; olfactory receptor Olr744; olfactory receptor gene Olr744", "tax_id": 10116, "disease": "", "pathway": " (rno:366122)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V8X0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V8Y0-1", "uniprot_id": [ { "id": "G3V8Y0_RAT", "url": "https://www.uniprot.org/uniprot/G3V8Y0", "type": "external" } ], "mass": 7979.0, "length": 67, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13", "gene_name": "Gng13", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13", "refseq_ac": [ { "id": "NP_001129390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129390", "type": "external" } ], "gene_names_uniprotkb": "Gng13", "gene_names_refseq": "Gng13; Hg3j", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13", "protein_names_refseq": "guanine nucleotide binding protein (G protein), gamma 13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13; heterotrimeric guanine nucleotide-binding protein 3j", "tax_id": 10116, "disease": "", "pathway": " (rno:685451)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding", "go_cellular_component": "GO:0030425 dendrite;GO:0045202 synapse;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0050909 sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V8Y0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V911-1", "uniprot_id": [ { "id": "G3V911_RAT", "url": "https://www.uniprot.org/uniprot/G3V911", "type": "external" } ], "mass": 97898.0, "length": 852, "protein_name": "Vomeronasal 2 receptor, 75", "gene_name": "Vom2r66; 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R611-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R6P8-1", "uniprot_id": [ { "id": "M0R6P8_RAT", "url": "https://www.uniprot.org/uniprot/M0R6P8", "type": "external" } ], "mass": 13542.0, "length": 116, "protein_name": "Transmembrane protein 262", "gene_name": "Catsperh", "organism": "Rat", "refseq_name": "cation channel sperm-associated auxiliary subunit TMEM262", "refseq_ac": [ { "id": "NP_001229562", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229562", "type": "external" } ], "gene_names_uniprotkb": "Catsperh; LOC100365733; Tmem262", "gene_names_refseq": "Catsperh; Tmem262", "protein_names_uniprotkb": "Transmembrane protein 262", "protein_names_refseq": "cation channel sperm-associated auxiliary subunit TMEM262; rCG48429-like; transmembrane protein 262", "tax_id": 10116, "disease": "", "pathway": " (rno:100365733)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036128 CatSper complex;GO:0097228 sperm principal piece", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R6P8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R785-1", "uniprot_id": [ { "id": "M0R785_RAT", "url": "https://www.uniprot.org/uniprot/M0R785", "type": "external" } ], "mass": 15849.0, "length": 154, "protein_name": "Coiled-coil-helix-coiled-coil-helix domain containing protein 2-like 3", "gene_name": "Chchd2l3; Chchd2", "organism": "Rat", "refseq_name": "coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial", "refseq_ac": [ { "id": "NP_001015019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015019", "type": "external" } ], "gene_names_uniprotkb": "Chchd2l3; Chchd2", "gene_names_refseq": "Chchd2l3; Chchd2; Scand3-ps1", "protein_names_uniprotkb": "Coiled-coil-helix-coiled-coil-helix domain containing protein 2-like 3", "protein_names_refseq": "SCAN domain containing 3 pseudogene; SCAN domain containing 3, pseudogene 1; coiled-coil-helix-coiled-coil-helix domain containing 2-like 3; coiled-coil-helix-coiled-coil-helix domain containing 2; coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial-like; coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial", "tax_id": 10116, "disease": "frontotemporal dementia and/or amyotrophic lateral sclerosis 2 (Disease Ontology:DOID:0060214); Parkinson's disease 22 (Disease Ontology:DOID:0080504); spinal muscular atrophy, Jokela type (Disease Ontology:DOID:0081356); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:316643)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043565 sequence-specific DNA binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007005 mitochondrion organization;GO:0034599 cellular response to oxidative stress;GO:1900037 regulation of cellular response to hypoxia;GO:1905448 positive regulation of mitochondrial ATP synthesis coupled electron transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R785-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RB75-1", "uniprot_id": [ { "id": "M0RB75_RAT", "url": "https://www.uniprot.org/uniprot/M0RB75", "type": "external" } ], "mass": 122779.0, "length": 1099, "protein_name": "Lysine-specific demethylase 4B", "gene_name": "Kdm4b", "organism": "Rat", "refseq_name": "lysine-specific demethylase 4B isoform 1", "refseq_ac": [ { "id": "NP_001037701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037701", "type": "external" } ], "gene_names_uniprotkb": "Kdm4b", "gene_names_refseq": "Kdm4b", "protein_names_uniprotkb": "Lysine-specific demethylase 4B; 1.14.11.66; JmjC domain-containing histone demethylation protein 3B; Jumonji domain-containing protein 2B; [histone H3]-trimethyl-L-lysine(9) demethylase 4B", "protein_names_refseq": "lysine (K)-specific demethylase 4B; lysine-specific demethylase 4B isoform 1; lysine-specific demethylase 4B", "tax_id": 10116, "disease": "medulloblastoma (Disease Ontology:DOID:0050902); autosomal dominant intellectual developmental disorder 65 (Disease Ontology:DOID:0061038); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); malignant peripheral nerve sheath tumor (Disease Ontology:DOID:5940); colorectal cancer (Disease Ontology:DOID:9256); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (rno:301128); (R-RNO-3214842); (R-RNO-5693565); (R-RNO-9018519)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "29393594;32594337", "class_list": "", "function": "Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Plays a critical role in the development of the central nervous system (CNS)., [UniProtKB, UniProtKB, UniProtKB]; Osmolarity controls the differentiation of adipose-derived stem cells into nucleus pulposus cells via histone demethylase KDM4B., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.79", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0008270 zinc ion binding;GO:0032454 histone H3K9 demethylase activity;GO:0140684 histone H3K9me2/H3K9me3 demethylase activity;GO:0032452 histone demethylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0007420 brain development;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "M0RB75-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RDU0-1", "uniprot_id": [ { "id": "HAP40_RAT", "url": "https://www.uniprot.org/uniprot/M0RDU0", "type": "external" } ], "mass": 40544.0, "length": 381, "protein_name": "40-kDa huntingtin-associated protein", "gene_name": "F8a1", "organism": "Rat", "refseq_name": "40-kDa huntingtin-associated protein", "refseq_ac": [ { "id": "NP_001102793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102793", "type": "external" } ], "gene_names_uniprotkb": "F8a1; F8a; Hap40", "gene_names_refseq": "F8a1; F8a; Hap40; RGD1566014", "protein_names_uniprotkb": "40-kDa huntingtin-associated protein; Factor VIII intron 22 protein", "protein_names_refseq": "40-kDa huntingtin-associated protein; coagulation factor VIII-associated (intronic transcript) 1; factor 8-associated gene A; factor VIII intron 22 protein; huntingtin-associated protein 40", "tax_id": 10116, "disease": "", "pathway": " (rno:501661)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11035034;16476778;29393594", "class_list": "", "function": "RAB5A effector molecule that is involved in vesicular trafficking of early endosomes. Mediates the recruitment of HTT by RAB5A onto early endosomes. The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility., [UniProtKB, PubMed]; We have identified Huntingtin (Htt)-associated protein 40 (HAP40) as a novel effector of the small guanosine triphosphatase Rab5, a key regulator of endocytosis. HAP40 mediates the recruitment of Htt by Rab5 onto early endosomes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005769 early endosome;GO:0016604 nuclear body", "go_biological_process": "GO:1901799 negative regulation of proteasomal protein catabolic process;GO:0099518 vesicle cytoskeletal trafficking", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "M0RDU0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RDU9-1", "uniprot_id": [ { "id": "M0RDU9_RAT", "url": "https://www.uniprot.org/uniprot/M0RDU9", "type": "external" } ], "mass": 49014.0, "length": 436, "protein_name": "ADP-ribosylation factor like GTPase 13B", "gene_name": "Arl13b", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Arl13b", "gene_names_refseq": "", "protein_names_uniprotkb": "ADP-ribosylation factor like GTPase 13B", "protein_names_refseq": "", "tax_id": 10116, "disease": "Joubert syndrome 8 (Disease Ontology:DOID:0111003)", "pathway": " (rno:304037); (R-RNO-5624958); (R-RNO-9013406); (R-RNO-9646399)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0005929 cilium;GO:0031514 motile cilium;GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge;GO:0005930 axoneme", "go_biological_process": "GO:0001822 kidney development;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0001947 heart looping;GO:0070986 left/right axis specification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RDU9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54854-1", "uniprot_id": [ { "id": "O54854_RAT", "url": "https://www.uniprot.org/uniprot/O54854", "type": "external" } ], "mass": 28014.0, "length": 251, "protein_name": "Kallikrein related-peptidase 6", "gene_name": "Klk6", "organism": "Rat", "refseq_name": "kallikrein-6 precursor", "refseq_ac": [ { "id": "NP_062048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062048", "type": "external" } ], "gene_names_uniprotkb": "Klk6", "gene_names_refseq": "Klk6; 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Cartilage matrix protein", "protein_names_refseq": "cartilage matrix protein precursor; cartilage matrix protein; matrilin 1, cartilage matrix protein", "tax_id": 10116, "disease": "", "pathway": " (rno:297894)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "A major component of the extracellular matrix of non-articular cartilage. Binds to type 2 collagens and forms long concatenated protein networks as part of the extracellular matrix. Required for the network-like organization and bundling of collagen fibrils surrounding chondrocytes in the zones of maturation and hypertrophy. Required for mechanotransduction and adaption to mechanical loading in cartilage chondrocytes, resulting in an increase in expression of the extracellular matrix components ACAN and COL2A1. Acts as a moderator of angiogenesis in response to injury., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0002062 chondrocyte differentiation;GO:0030500 regulation of bone mineralization;GO:0003429 growth plate cartilage chondrocyte morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI24-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIF2-1", "uniprot_id": [ { "id": "Q5XIF2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIF2", "type": "external" } ], "mass": 29342.0, "length": 273, "protein_name": "Uroporphyrinogen-III synthase", "gene_name": "Uros", "organism": "Rat", "refseq_name": "uroporphyrinogen-III synthase isoform X1", "refseq_ac": [ { "id": "XP_008758113", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008758113", "type": "external" } ], "gene_names_uniprotkb": "Uros", "gene_names_refseq": "Uros", "protein_names_uniprotkb": "Uroporphyrinogen-III synthase; 4.2.1.75; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase", "protein_names_refseq": "uroporphyrinogen-III synthase isoform X1", "tax_id": 10116, "disease": "erythropoietic protoporphyria (Disease Ontology:DOID:13270); cutaneous porphyria (Disease Ontology:DOID:13271)", "pathway": " (rno:309070); (R-RNO-189451)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.75", "type": "external" } ], "go_molecular_function": "GO:0005542 folic acid binding;GO:0004852 uroporphyrinogen-III synthase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006779 porphyrin-containing compound biosynthetic process;GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process;GO:0070541 response to platinum ion;GO:0071243 cellular response to arsenic-containing substance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIF2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MGB4-1", "uniprot_id": [ { "id": "S39A7_RAT", "url": "https://www.uniprot.org/uniprot/Q6MGB4", "type": "external" } ], "mass": 49499.0, "length": 468, "protein_name": "Zinc transporter SLC39A7", "gene_name": "Slc39a7", "organism": "Rat", "refseq_name": "zinc transporter SLC39A7 precursor", "refseq_ac": [ { "id": "NP_001008885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008885", "type": "external" } ], "gene_names_uniprotkb": "Slc39a7", "gene_names_refseq": "Ke4; RT1-Ke4; Rt1Ke4; Slc39a7; ZIP7", "protein_names_uniprotkb": "Zinc transporter SLC39A7; Solute carrier family 39 member 7; ZIP7; Zrt-, Irt-like protein 7", "protein_names_refseq": "Histidine-rich membrane protein; RT1 class I, locus Ke4; RT1 region expressed gene KE4; solute carrier family 39 (zinc transporter), member 7; zinc transporter SLC39A7 precursor; zinc transporter SLC39A7; zrt-, Irt-like protein 7", "tax_id": 10116, "disease": "agammaglobulinemia 9 (Disease Ontology:DOID:0081141)", "pathway": " (rno:294281); (R-RNO-442380)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15060004;28232492;29307859", "class_list": "", "function": "Markedly increased mRNA and protein levels of ZIP7 were observed in ventricular cardiomyocytes from diabetic rats or high-glucose-treated H9c2 cells while ZnT7 expression was low. ZIP7 phosphorylation was increased in response to high glucose in vivo and in vitro., [RefSeq, PubMed]; Overall, this study provides an important description about the role of ZIP7 and ZnT7, localized to both mitochondria and sarco(endo)plasmic reticulum and contribute to cellular Zn(2+)-muffling between cellular-compartments in hyperglycemia or hypertrophic cardiomyocytes via affecting sarco(endo)plasmic reticulum-mitochondria coupling., [RefSeq, PubMed]; Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels. Acts as a gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation on residues, resulting in activation of multiple downstream pathways leading to cell growth and proliferation. Has an essential role in B cell development and is required for proper B cell receptor signaling (By similarity). Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function. Controls cell signaling pathways involved in glucose metabolism in skeletal muscle (By similarity). Has a protective role against ER stress in different biological contexts (PubMed:28232492). Mediates Zn(2+)-induced ferroptosis (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F7EQL7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0098773 skin epidermis development;GO:0030183 B cell differentiation;GO:0006882 intracellular zinc ion homeostasis;GO:0110075 regulation of ferroptosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6MGB4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QLN3-1", "uniprot_id": [ { "id": "Q6QLN3_RAT", "url": "https://www.uniprot.org/uniprot/Q6QLN3", "type": "external" } ], "mass": 57789.0, "length": 503, "protein_name": "NOP53 ribosome biogenesis factor", "gene_name": "Nop53", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nop53; Gltscr2", "gene_names_refseq": "", "protein_names_uniprotkb": "NOP53 ribosome biogenesis factor", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:292624)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in ribosome biogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6J885", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0002039 p53 binding;GO:0008097 5S rRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0001650 fibrillar center;GO:0033553 rDNA heterochromatin", "go_biological_process": "GO:1902570 protein localization to nucleolus;GO:1903006 positive regulation of protein K63-linked deubiquitination;GO:1990173 protein localization to nucleoplasm;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6QLN3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TUE9-1", "uniprot_id": [ { "id": "Q6TUE9_RAT", "url": "https://www.uniprot.org/uniprot/Q6TUE9", "type": "external" } ], "mass": 36863.0, "length": 334, "protein_name": "Uncharacterized protein", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6TUE9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TPB3-1", "uniprot_id": [ { "id": "Q7TPB3_RAT", "url": "https://www.uniprot.org/uniprot/Q7TPB3", "type": "external" } ], "mass": 62176.0, "length": 533, "protein_name": "Zinc finger protein 472", "gene_name": "Zfp472", "organism": "Rat", "refseq_name": "zinc finger protein 472", "refseq_ac": [ { "id": "NP_877975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_877975", "type": "external" } ], "gene_names_uniprotkb": "Zfp472", "gene_names_refseq": "KRIM-1; Krim1; Zfp472", "protein_names_uniprotkb": "Zinc finger protein 472", "protein_names_refseq": "KRAB box containing zinc finger protein; zinc finger protein 472", "tax_id": 10116, "disease": "", "pathway": " (rno:314587)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12748187", "class_list": "", "function": "Findings suggest that Myc-mediated functions can be negatively regulated by KRAB box containing zinc finger protein (Krim-1), [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F7EM21", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TPB3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XZ1-1", "uniprot_id": [ { "id": "Q80XZ1_RAT", "url": "https://www.uniprot.org/uniprot/Q80XZ1", "type": "external" } ], "mass": 63722.0, "length": 588, "protein_name": "Polypyrimidine tract-binding protein", "gene_name": "Smptb", "organism": "Rat", "refseq_name": "polypyrimidine tract-binding protein", "refseq_ac": [ { "id": "NP_877970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_877970", "type": "external" } ], "gene_names_uniprotkb": "Smptb; LOC120099267", "gene_names_refseq": "Smptb", "protein_names_uniprotkb": "Polypyrimidine tract-binding protein", "protein_names_refseq": "polypyrimidine tract-binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:302879)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6KPC6", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045595 regulation of cell differentiation;GO:0043484 regulation of RNA splicing;GO:0000380 alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80XZ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5G4-1", "uniprot_id": [ { "id": "Q8R5G4_RAT", "url": "https://www.uniprot.org/uniprot/Q8R5G4", "type": "external" } ], "mass": 18165.0, "length": 168, "protein_name": "Cyclin-dependent kinase 4 inhibitor C", "gene_name": "Cdkn2c", "organism": "Rat", "refseq_name": "cyclin-dependent kinase 4 inhibitor C", "refseq_ac": [ { "id": "NP_571977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571977", "type": "external" } ], "gene_names_uniprotkb": "Cdkn2c", "gene_names_refseq": "Cdkn2c; p18", "protein_names_uniprotkb": "Cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6", "protein_names_refseq": "cyclin-dependent kinase 4 inhibitor C; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)", "tax_id": 10116, "disease": "", "pathway": " (rno:54238)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11969268", "class_list": "", "function": "Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB., [UniProtKB, UniProtKB]; Posttranscriptional regulation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6JYZ7;Q8R5G3", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0030308 negative regulation of cell growth;GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:2000045 regulation of G1/S transition of mitotic cell cycle;GO:0048709 oligodendrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R5G4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHD7-1", "uniprot_id": [ { "id": "GPR83_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHD7", "type": "external" } ], "mass": 47957.0, "length": 422, "protein_name": "G protein-coupled receptor 83", "gene_name": "Gpr83", "organism": "Rat", "refseq_name": "G-protein coupled receptor 83 precursor", "refseq_ac": [ { "id": "NP_536336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536336", "type": "external" } ], "gene_names_uniprotkb": "Gpr83; Gir", "gene_names_refseq": "Gir; Gpr83", "protein_names_uniprotkb": "G protein-coupled receptor 83; Glucocorticoid-induced receptor", "protein_names_refseq": "G-protein coupled receptor 83 precursor; glucocorticoid-induced receptor; probable G-protein coupled receptor 83", "tax_id": 10116, "disease": "", "pathway": " (rno:140595)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11698613;17240481", "class_list": "", "function": "G protein-coupled peptide receptor. Several peptides, PEN, derived from the proSAAS precursor (encoded by PCSK1N), the procholecystokinin-derived peptide proCCK56-63, and the related proteins FAM237A and FAM237B have been reported to activate GPR83 through GNAI1/G(i) and GNAS/G(s)-mediated signaling pathways. G protein-coupled peptide receptor (By similarity). However, due to conflicting evidence about the ability of these peptides to bind to and activate the GPR83, the endogenous ligand of GPR83 still remains uncertain. Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-mediated pathway in response to PEN. Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008188 neuropeptide receptor activity;GO:0004983 neuropeptide Y receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0097730 non-motile cilium;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0051384 response to glucocorticoid;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007631 feeding behavior", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VHD7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "W8CC80-1", "uniprot_id": [ { "id": "W8CC80_RAT", "url": "https://www.uniprot.org/uniprot/W8CC80", "type": "external" } ], "mass": 43910.0, "length": 388, "protein_name": "RNA binding motif protein, Y-linked, family 1, member J", "gene_name": "Rbmy1j", "organism": "Rat", "refseq_name": "RNA binding motif protein, Y-linked, family 1, member J", "refseq_ac": [ { "id": "NP_001395842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001395842", "type": "external" } ], "gene_names_uniprotkb": "Rbmy1j", "gene_names_refseq": "RBMY; Rbmy1j", "protein_names_uniprotkb": "RNA binding motif protein, Y-linked, family 1, member J", "protein_names_refseq": "RNA binding motif protein Y-linked; RNA binding motif protein, Y-linked, family 1, member J; RNA-binding motif protein, Y chromosome, family 1 member B-like", "tax_id": 10116, "disease": "", "pathway": " (rno:103694544)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0042802 identical protein binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005681 spliceosomal complex;GO:0005634 nucleus", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0006376 mRNA splice site recognition;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "W8CC80-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28480-1", "uniprot_id": [ { "id": "TCPA_RAT", "url": "https://www.uniprot.org/uniprot/P28480", "type": "external" } ], "mass": 60360.0, "length": 556, "protein_name": "T-complex protein 1 subunit alpha", "gene_name": "Tcp1", "organism": "Rat", "refseq_name": "T-complex protein 1 subunit alpha", "refseq_ac": [ { "id": "NP_036802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036802", "type": "external" } ], "gene_names_uniprotkb": "Tcp1; Cct1; Ccta", "gene_names_refseq": "CCTalpha; Tcp-1; Tcp1", "protein_names_uniprotkb": "T-complex protein 1 subunit alpha; 3.6.1.-; CCT-alpha; TCP-1-alpha", "protein_names_refseq": "CCT-alpha; T-complex protein 1 subunit alpha; TCP-1-alpha", "tax_id": 10116, "disease": "", "pathway": " (rno:24818); (R-RNO-390471); (R-RNO-5620922); (R-RNO-6814122)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "1756183;1937024;22673903;34502162;38843836", "class_list": "", "function": "Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005874 microtubule;GO:0001669 acrosomal vesicle;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0090666 scaRNA localization to Cajal body;GO:0007339 binding of sperm to zona pellucida;GO:0007286 spermatid development;GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P28480-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C9WPN6-1", "uniprot_id": [ { "id": "IF2H_RAT", "url": "https://www.uniprot.org/uniprot/C9WPN6", "type": "external" } ], "mass": 51154.0, "length": 472, "protein_name": "Eukaryotic translation initiation factor 2 subunit 3, Y-linked", "gene_name": "Eif2s3y; Eif2s3", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 2 subunit 3, Y-linked", "refseq_ac": [ { "id": "NP_001161138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161138", "type": "external" } ], "gene_names_uniprotkb": "Eif2s3y; Eif2s3; Eif2s3y", "gene_names_refseq": "Eif2s3y", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2 subunit 3, Y-linked; 3.6.5.3; Eukaryotic translation initiation factor 2 subunit gamma, Y-linked; eIF-2-gamma Y", "protein_names_refseq": "eIF-2-gamma Y; eukaryotic translation initiation factor 2 subunit 3, Y-linked; eukaryotic translation initiation factor 2 subunit gamma, Y-linked; eukaryotic translation initiation factor 2, subunit 3 gamma", "tax_id": 10116, "disease": "MEHMO syndrome (Disease Ontology:DOID:0060801); leukodystrophy (Disease Ontology:DOID:10579); glucose metabolism disease (Disease Ontology:DOID:4194); hypopituitarism (Disease Ontology:DOID:9406)", "pathway": " (rno:100312984)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20333173;24759410;25548914;9736774", "class_list": "", "function": "Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). Along with its paralog on chromosome X, may contribute to spermatogenesis up to the round spermatid stage (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A096MIV4;A0A0G2JU42;C9WPN7;W8CEN7", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0000049 tRNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005850 eukaryotic translation initiation factor 2 complex", "go_biological_process": "GO:2000020 positive regulation of male gonad development;GO:0007283 spermatogenesis;GO:0001731 formation of translation preinitiation complex", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "C9WPN6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35763-1", "uniprot_id": [ { "id": "MOES_RAT", "url": "https://www.uniprot.org/uniprot/O35763", "type": "external" } ], "mass": 67739.0, "length": 577, "protein_name": "Moesin", "gene_name": "Msn", "organism": "Rat", "refseq_name": "moesin", "refseq_ac": [ { "id": "NP_110490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110490", "type": "external" } ], "gene_names_uniprotkb": "Msn", "gene_names_refseq": "Msn", "protein_names_uniprotkb": "Moesin; Membrane-organizing extension spike protein", "protein_names_refseq": "membrane-organizing extension spike protein; moesin", "tax_id": 10116, "disease": "immunodeficiency 50 (Disease Ontology:DOID:0112001); primary biliary cholangitis (Disease Ontology:DOID:12236)", "pathway": " (rno:81521); (R-RNO-437239)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10945828;11867620;15031678;15634677;17447891;20307615;22673903;27342875;30448045;34502162;37569454", "class_list": "", "function": "Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton. Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement. These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction. The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (By similarity). Modulates phagolysosomal biogenesis in macrophages (By similarity). Participates also in immunologic synapse formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Phosphorylated ERM Mediates Lipopolysaccharide Induced Pulmonary Microvascular Endothelial Cells Permeability Through Negatively Regulating Rac1 Activity., [RefSeq, PubMed]; Potential Role of Moesin in Regulating Mast Cell Secretion. Review article Publication Status: Online-Only, [RefSeq, PubMed]; RhoA and Rho kinase-dependent phosphorylation of moesin at Thr-558 in hippocampal neuronal cells by glutamate, [RefSeq, PubMed]; The expression of moesin was upregulated in cardiomyocytes under inflammation, inducing protrusion formation in a phosphorylation-dependent fashion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0051286 cell tip;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005925 focal adhesion", "go_biological_process": "GO:1902966 positive regulation of protein localization to early endosome;GO:0097305 response to alcohol;GO:0022614 membrane to membrane docking;GO:0061028 establishment of endothelial barrier;GO:1902115 regulation of organelle assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O35763-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZEH5-1", "uniprot_id": [ { "id": "SIDT2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZEH5", "type": "external" } ], "mass": 94527.0, "length": 832, "protein_name": "SID1 transmembrane family member 2", "gene_name": "Sidt2", "organism": "Rat", "refseq_name": "SID1 transmembrane family member 2 isoform 3 precursor", "refseq_ac": [ { "id": "NP_001416599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001416599", "type": "external" } ], "gene_names_uniprotkb": "Sidt2", "gene_names_refseq": "RGD1308311; Sidt2", "protein_names_uniprotkb": "SID1 transmembrane family member 2", "protein_names_refseq": "SID1 transmembrane family member 2 isoform 3 precursor", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208)", "pathway": " (rno:315617)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20965152;22673903;26884831;38843836", "class_list": "", "function": "Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (By similarity). In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Sdit2 may play a vital role in the regulation of insulin secretion via two SNARE proteins synap1 and syanp3. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "D3ZSU1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0035612 AP-2 adaptor complex binding;GO:0003725 double-stranded RNA binding;GO:0035650 AP-1 adaptor complex binding;GO:0051033 RNA transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0016020 membrane", "go_biological_process": "GO:0000902 cell morphogenesis;GO:0042593 glucose homeostasis;GO:0009749 response to glucose;GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0050658 RNA transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D3ZEH5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88959-1", "uniprot_id": [ { "id": "INHBE_RAT", "url": "https://www.uniprot.org/uniprot/O88959", "type": "external" } ], "mass": 38899.0, "length": 350, "protein_name": "Inhibin beta E chain", "gene_name": "Inhbe", "organism": "Rat", "refseq_name": "inhibin beta E chain precursor", "refseq_ac": [ { "id": "NP_114003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114003", "type": "external" } ], "gene_names_uniprotkb": "Inhbe", "gene_names_refseq": "Inhbe", "protein_names_uniprotkb": "Inhibin beta E chain; Activin beta-E chain", "protein_names_refseq": "activin beta E; activin beta-E chain; inhibin beta E chain precursor; inhibin beta E chain; inhibin beta E subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:83711); (R-RNO-209822)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10828834;11932210;12865331;16935389;29393594", "class_list": "", "function": "Activin E is a homodimer of INHBE secreted by the liver that plays a crucial role in regulating metabolic homeostasis particularly in lipid metabolism and energy homeostasis. Plays a central role in the regulation of adipose tissue lipolysis by preventing the influx of fatty acids from adipose tissue into the liver. Mechanistically, signals via ACVR1C to activate SMAD2/3 signaling, suppressing PPARG target genes in adipose tissue, thereby reducing liver lipid content and improving glycemic control. Induces beige adipocyte formation and thermogenesis in response to cold exposure., [UniProtKB, UniProtKB, UniProtKB]; Expression and dimerization of the rat activin subunits betaC and betaE: evidence for the ormation of novel activin dimers., [RefSeq, PubMed]; First report of a biological activity of activin C and E supports an involvement in liver tissue homeostasis, [RefSeq, PubMed]; Follistatin was overexpressed while both activin subunits were downregulated in the majority of rat and human liver tumours, [RefSeq, PubMed]; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R285", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0071397 cellular response to cholesterol;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:1904178 negative regulation of adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O88959-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48056-1", "uniprot_id": [ { "id": "S6A12_RAT", "url": "https://www.uniprot.org/uniprot/P48056", "type": "external" } ], "mass": 69749.0, "length": 614, "protein_name": "Sodium- and chloride-dependent betaine transporter", "gene_name": "Slc6a12", "organism": "Rat", "refseq_name": "sodium- and chloride-dependent betaine transporter", "refseq_ac": [ { "id": "NP_059031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059031", "type": "external" } ], "gene_names_uniprotkb": "Slc6a12", "gene_names_refseq": "BGT1; Gat1; RNU28927; Slc6a12; VGAT", "protein_names_uniprotkb": "Sodium- and chloride-dependent betaine transporter; Na(+)/Cl(-) betaine/GABA transporter; Solute carrier family 6 member 12", "protein_names_refseq": "Betaine/GABA transporter 1; GABA transporter 1; Na(+)/Cl(-) betaine/GABA transporter; sodium- and chloride-dependent betaine transporter; solute carrier family 6 (neurotransmitter transporter), member 12; solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12; vesicular GABA transporter", "tax_id": 10116, "disease": "", "pathway": " (rno:50676); (R-RNO-352230); (R-RNO-71288); (R-RNO-888593)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "12614674;14663191;14761965;15073174;22616751;22673903;23090943;23381899;23804087;35933616;8865807", "class_list": "", "function": "Changes in vesicular glutamate transporter 2 (Vglut2) and vesicular GABA transporter 1 (Vgat1) in the orofacial pain and temperature perception pathway under low estrogen conditions., [RefSeq, PubMed]; During neocortical development the expression of GABA transporter in the cerebral cortex slightly precedes the complete maturation of inhibitory synaptogenesis and suggests that it may contribute to the formation of neocortical GABAergic circuitry., [RefSeq, PubMed]; GABA transporter can exist in either of two mutually exclusive phosphorylation states and that the relative abundance of these states determines in part the relative subcellular distribution of the transporter, [RefSeq, PubMed]; GAT-1, which is predominantly presynaptically located, is the major GABA transporter in the hippocampus under baseline, quiescent conditions., [RefSeq, PubMed]; GAT1 mRNA expression is initially up-regulated in the ipsilateral vestibular nucleus and then undergoes a bilateral increase 50 h after labyrinthectomy., [RefSeq, PubMed]; The results demonstrate a malfunction of GAT-1 in thalamic astrocytes of a well-established genetic model of absence epilepsy, and indicate that this abnormality is not a reflection of a general pathology affecting all astrocytic functions., [RefSeq, PubMed]; This study provides evidence that the GAT-1-mediated regulation of extracellular GABA can modulate glutamatergic transmission at the subthalamopallidal synapse in the rat globus pallidus., [RefSeq, PubMed]; Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation (By similarity). Probably also involved in renal and hepatic osmotic regulation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Two discontinuous segments in the carboxyl terminus are required for membrane targeting of the rat GAT1, [RefSeq, PubMed]; We report the identification of a unique amino acid motif in the vesicular GABA transporter (VGAT) that controls its synaptic localization and activity-dependent recycling, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0042995 cell projection", "go_biological_process": "GO:0031460 glycine betaine transport;GO:0006865 amino acid transport;GO:0009992 intracellular water homeostasis;GO:0035725 sodium ion transmembrane transport;GO:0071474 cellular hyperosmotic response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P48056-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88406-1", "uniprot_id": [ { "id": "SMAD7_RAT", "url": "https://www.uniprot.org/uniprot/O88406", "type": "external" } ], "mass": 46458.0, "length": 426, "protein_name": "SMAD family member 7", "gene_name": "Smad7", "organism": "Rat", "refseq_name": "SMAD family member 7", "refseq_ac": [ { "id": "NP_110485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110485", "type": "external" } ], "gene_names_uniprotkb": "Smad7; Madh7", "gene_names_refseq": "Madh7; Smad7", "protein_names_uniprotkb": "SMAD family member 7; MAD homolog 7; Mothers against DPP homolog 7; Mothers against decapentaplegic homolog 7; SMAD 7", "protein_names_refseq": "MAD (mothers against decapentaplegic, Drosophila) homolog 7; MAD homolog 7; SMAD 7; SMAD family member 7; mothers against DPP homolog 7; mothers against decapentaplegic homolog 7", "tax_id": 10116, "disease": "nephritis (Disease Ontology:DOID:10952); endometrial cancer (Disease Ontology:DOID:1380); pancreatic cancer (Disease Ontology:DOID:1793); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); liver cirrhosis (Disease Ontology:DOID:5082); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:81516); (R-RNO-201451); (R-RNO-2173788); (R-RNO-2173796); (R-RNO-5689880)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "10656934;11181520;34951337;35611880;35795857;37976598;38654161", "class_list": "", "function": "Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator., [UniProtKB, UniProtKB]; Circ_0058792 regulates osteogenic differentiation through miR-181a-5p/Smad7 axis in steroid-induced osteonecrosis of the femoral head., [RefSeq, PubMed]; Diabetic and nondiabetic BMSC-derived exosomes affect bone regeneration via regulating miR-17-5p/SMAD7 axis., [RefSeq, PubMed]; MiR-410-3p facilitates Angiotensin II-induced cardiac hypertrophy by targeting Smad7., [RefSeq, PubMed]; Mir-195-5p targets Smad7 regulation of the Wnt/beta-catenin pathway to promote osteogenic differentiation of vascular smooth muscle cells. Publication Status: Online-Only, [RefSeq, PubMed]; Smad7 Is Highly Expressed in Human Degenerative Discs and Participates in IL-1beta-Induced Apoptosis of Rat AF Cells via the Mitochondria Pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QUG1", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity;GO:0031625 ubiquitin protein ligase binding;GO:0005518 collagen binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization;GO:2000317 negative regulation of T-helper 17 type immune response;GO:0002725 negative regulation of T cell cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88406-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00758-1", "uniprot_id": [ { "id": "KLK1_RAT", "url": "https://www.uniprot.org/uniprot/P00758", "type": "external" } ], "mass": 28852.0, "length": 261, "protein_name": "Kallikrein-1", "gene_name": "Klk1b3; Ngfg", "organism": "Rat", "refseq_name": "kallikrein 1-related peptidase B3 precursor", "refseq_ac": [ { "id": "NP_113711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113711", "type": "external" } ], "gene_names_uniprotkb": "Klk1b3; Ngfg; Klk-1; Klk1", "gene_names_refseq": "Klk1b3; Klk1c1; Klk1; Klna4; Ngfg; rGK-1; rK-1", "protein_names_uniprotkb": "Kallikrein-1; 3.4.21.35; Gamma-NGF; Nerve growth factor gamma chain; PS kallikrein; Pancreatic kallikrein; RGK-1; Tissue kallikrein; True kallikrein; True tissue kallikrein; rK-1", "protein_names_refseq": "PS kallikrein; gamma-NGF; kallikrein 1-related peptidase B3 precursor; kallikrein 1; kallikrein a4; nerve growth factor gamma chain; nerve growth factor gamma polypeptide; pancreatic kallikrein; true tissue kallikrein", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); breast cancer (Disease Ontology:DOID:1612); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (rno:24594); (R-RNO-381426)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17060174;19879874;22739815;22865451;24019890;2708383;2753879;2998455;3004582;6961406", "class_list": "", "function": "Ability of hTK gene-transduced EPCs can be enhanced in vitro, in which integrin alphavbeta3 plays a role in the process Publication Status: Online-Only, [RefSeq, PubMed]; Observations demonstrate a novel role of plasma kallikrein and bradykinin activation in the synovial recruitment of endothelial stem cells in arthritis, acting via kallikrein activation and B2R-dependent mechanisms., [RefSeq, PubMed]; Results suggest that the results suggest that the kallikrein-kinin system (KKS) plays a role in the effects of radiation on cardiac function and recruitment of inflammatory cells., [RefSeq, PubMed]; The present findings suggest that at least NGF does not act as a proper proinflammatory factor but most probably as a neuroimmune modulator molecule of the allergic state., [RefSeq, PubMed]; The study demonstrates a novel role of TK in skin wound healing uncovering new signaling pathway mediated by TK in promoting keratinocyte migration through activation of the PAR(1)-PKC-Src-MMP pathway and HB-EGF/AR shedding-dependent EGFR transactivation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q68G17", "ec_number_list": [ { "id": "3.4.21.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.35", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P00758-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52632-1", "uniprot_id": [ { "id": "STA5B_RAT", "url": "https://www.uniprot.org/uniprot/P52632", "type": "external" } ], "mass": 90223.0, "length": 786, "protein_name": "Signal transducer and activator of transcription 5B", "gene_name": "Stat5b", "organism": "Rat", "refseq_name": "signal transducer and activator of transcription 5B", "refseq_ac": [ { "id": "NP_071775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071775", "type": "external" } ], "gene_names_uniprotkb": "Stat5b", "gene_names_refseq": "Stat5b", "protein_names_uniprotkb": "Signal transducer and activator of transcription 5B", "protein_names_refseq": "Signal transducer and activator of transcription 5a; signal transducer and activator of transcription 5B", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); growth hormone insensitivity syndrome with immune dysregulation 1 (Disease Ontology:DOID:0080836); growth hormone insensitivity syndrome with immune dysregulation 2 (Disease Ontology:DOID:0080837); colon adenocarcinoma (Disease Ontology:DOID:234); gingivitis (Disease Ontology:DOID:3087); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684); periodontitis (Disease Ontology:DOID:824); tendinitis (Disease Ontology:DOID:971)", "pathway": " (rno:25126); (R-RNO-1266695); (R-RNO-1433557); (R-RNO-186763); (R-RNO-512988); (R-RNO-8854691); (R-RNO-8983432); (R-RNO-8985947); (R-RNO-9020558); (R-RNO-9020958); (R-RNO-982772)", "pathway_count": 11, "publication_count": 3, "publication_id_list": "14764607;22673903;8530402", "class_list": "", "function": "Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Signal transducer and transcription activator that mediates cellular responses to cytokines, hormones and growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. Involved in the oncostatin-M-mediated signaling pathway through type II OSM receptor complex (heterodimers composed of OSMR and IL6ST)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0046543 development of secondary female sexual characteristics;GO:0070669 response to interleukin-2;GO:0046544 development of secondary male sexual characteristics;GO:0097531 mast cell migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P52632-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01346-1", "uniprot_id": [ { "id": "IGF2_RAT", "url": "https://www.uniprot.org/uniprot/P01346", "type": "external" } ], "mass": 20086.0, "length": 180, "protein_name": "Insulin-like growth factor 2", "gene_name": "Igf2", "organism": "Rat", "refseq_name": "insulin-like growth factor 2 isoform 2 preproprotein", "refseq_ac": [ { "id": "NP_001177091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177091", "type": "external" } ], "gene_names_uniprotkb": "Igf2; Igf-2", "gene_names_refseq": "IGFII; Igf2; RNIGF2", "protein_names_uniprotkb": "Insulin-like growth factor 2; IGF-II; Insulin-like growth factor II; MSA; Multiplication-stimulating activity; Multiplication-stimulating polypeptide", "protein_names_refseq": "IGF-II; Insulin-like growth factor II (somatomedin A); MSA; insulin-like growth factor 2 isoform 2 preproprotein; insulin-like growth factor II (IGF-II); multiplication-stimulating activity; multiplication-stimulating polypeptide", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); alcohol-associated liver disease (Disease Ontology:DOID:0070658); congenital disorder of glycosylation Ia (Disease Ontology:DOID:0080552); type 1 diabetes mellitus 2 (Disease Ontology:DOID:0110741); Alzheimer's disease (Disease Ontology:DOID:10652); osteoporosis (Disease Ontology:DOID:11476); Lewy body dementia (Disease Ontology:DOID:12217); alcoholic neuropathy (Disease Ontology:DOID:14183); Parkinson's disease (Disease Ontology:DOID:14330); Silver-Russell syndrome (Disease Ontology:DOID:14681); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); ventricular septal defect (Disease Ontology:DOID:1657); multiple sclerosis (Disease Ontology:DOID:2377); brain infarction (Disease Ontology:DOID:3454); choriocarcinoma (Disease Ontology:DOID:3594); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); multiple system atrophy (Disease Ontology:DOID:4752); liver cirrhosis (Disease Ontology:DOID:5082); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); gastrointestinal system disease (Disease Ontology:DOID:77); osteoarthritis (Disease Ontology:DOID:8398); ulcerative colitis (Disease Ontology:DOID:8577); type 2 diabetes mellitus (Disease Ontology:DOID:9352); meningitis (Disease Ontology:DOID:9471); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24483); (R-RNO-114608); (R-RNO-2404192); (R-RNO-2428928); (R-RNO-2428933); (R-RNO-381426)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "16912056;2438416;3023383;30956007;3167060;3221878;32934005;33781005;33915127;37788670;3889836;6382022;6390212;7016879", "class_list": "", "function": "IGF2 expression in inguinal adipose tissues from rats of different ages., [RefSeq, PubMed]; Insulin-like growth factor-2 regulates basal retinal insulin receptor activity., [RefSeq, PubMed]; Integrin and autocrine IGF2 pathways control fasting insulin secretion in beta-cells., [RefSeq, PubMed]; Neuronal activity drives IGF2 expression from pericytes to form long-term memory., [RefSeq, PubMed]; Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The effect of thyroid dysfunction and treatment on adropin, asprosin and preptin levels in rats. Publication Status: Online-Only, [RefSeq, PubMed]; The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0005178 integrin binding;GO:0005159 insulin-like growth factor receptor binding;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0007613 memory;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P01346-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04812-1", "uniprot_id": [ { "id": "SVS5_RAT", "url": "https://www.uniprot.org/uniprot/P04812", "type": "external" } ], "mass": 13603.0, "length": 123, "protein_name": "Seminal vesicle secretory protein 5", "gene_name": "Svs5", "organism": "Rat", "refseq_name": "seminal vesicle secretory protein 5 precursor", "refseq_ac": [ { "id": "NP_598200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598200", "type": "external" } ], "gene_names_uniprotkb": "Svs5; Svp5", "gene_names_refseq": "Svs5", "protein_names_uniprotkb": "Seminal vesicle secretory protein 5; SVS V; SVS protein F; Seminal vesicle secretory protein V", "protein_names_refseq": "SVS V; SVS protein F; seminal vesicle secretion 5; seminal vesicle secretory protein 5 precursor; seminal vesicle secretory protein V", "tax_id": 10116, "disease": "", "pathway": " (rno:171027)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2987804;6548962", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P04812-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88563-1", "uniprot_id": [ { "id": "MRP3_RAT", "url": "https://www.uniprot.org/uniprot/O88563", "type": "external" } ], "mass": 168978.0, "length": 1522, "protein_name": "ATP-binding cassette sub-family C member 3", "gene_name": "Abcc3", "organism": "Rat", "refseq_name": "ATP-binding cassette sub-family C member 3", "refseq_ac": [ { "id": "NP_542148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542148", "type": "external" } ], "gene_names_uniprotkb": "Abcc3; Cmoat2; Mlp2; Mrp3", "gene_names_refseq": "Abcc3; Mlp2; Mrp3", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 3; 7.6.2.-; 7.6.2.2; 7.6.2.3; Canalicular multispecific organic anion transporter 2; MLP-2; MRP-like protein 2; Multidrug resistance-associated protein 3", "protein_names_refseq": "ATP-binding cassette sub-family C member 3; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; ATP-binding cassette, subfamily C (CFTR/MRP), member 3; MLP-2; MRP-like protein 2; canalicular multispecific organic anion transporter 2; multidrug resistance protein 3; multidrug resistance-associated protein 3", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Dubin-Johnson syndrome (Disease Ontology:DOID:12308); hyperprolactinemia (Disease Ontology:DOID:12700); cholestasis (Disease Ontology:DOID:13580); pancreatic cancer (Disease Ontology:DOID:1793); bilirubin metabolic disorder (Disease Ontology:DOID:2741); kidney disease (Disease Ontology:DOID:557); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); acute myeloid leukemia (Disease Ontology:DOID:9119); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:140668); (R-RNO-159418); (R-RNO-382556); (R-RNO-9749641); (R-RNO-9753281)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "10362653;10644759;11897632;22673903;26337276;9614210", "class_list": "", "function": "ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (By similarity). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; This report is the first to describe liver overexpression of Abcc3 during the cancer initiation, promotion, and progression periods in rat hepatocarcinogenesis model and in human hepatocellular carcinoma, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O88270", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0008559 ABC-type xenobiotic transporter activity;GO:0015432 ABC-type bile acid transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0098656 monoatomic anion transmembrane transport;GO:0032496 response to lipopolysaccharide;GO:0055085 transmembrane transport;GO:0015721 bile acid and bile salt transport;GO:0015722 canalicular bile acid transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88563-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09875-1", "uniprot_id": [ { "id": "UD2B1_RAT", "url": "https://www.uniprot.org/uniprot/P09875", "type": "external" } ], "mass": 60485.0, "length": 529, "protein_name": "UDP-glucuronosyltransferase 2B1", "gene_name": "Ugt2b1", "organism": "Rat", "refseq_name": "UDP-glucuronosyltransferase 2B1 precursor", "refseq_ac": [ { "id": "NP_775417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775417", "type": "external" } ], "gene_names_uniprotkb": "Ugt2b1; Udpgtr2; Ugt2b17", "gene_names_refseq": "2B1; Udpgtr2; Ugt2b17; Ugt2b1", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 2B1; 2.4.1.17; UDPGT 2B1; UDPGTr-2; UGT2B1", "protein_names_refseq": "UDP glucuronosyltransferase 2 family, polypeptide B17; UDP glucuronosyltransferase family 2 member B17; UDP-glucuronosyltransferase 2B1 precursor; UDP-glucuronosyltransferase 2B1; UDP-glucuronosyltransferase 2B4; UDPGT 2B1; UDPGTr-2; liver UDP-glucuronosyltransferase, phenobarbital-inducible form", "tax_id": 10116, "disease": "", "pathway": " (rno:286954); (R-RNO-156588); (R-RNO-9749641); (R-RNO-9757110)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "18719240;2113533;3084479", "class_list": "glycogene;glycosyltransferase", "function": "UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240). Catalyzes the glucuronidation of the endogenous estrogen hormone estradiol (PubMed:18719240)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" } ], "go_molecular_function": "GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0071378 cellular response to growth hormone stimulus;GO:0032496 response to lipopolysaccharide;GO:0051260 protein homooligomerization;GO:0051291 protein heterooligomerization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P09875-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50282-1", "uniprot_id": [ { "id": "MMP9_RAT", "url": "https://www.uniprot.org/uniprot/P50282", "type": "external" } ], "mass": 78611.0, "length": 708, "protein_name": "Matrix metalloproteinase-9", "gene_name": "Mmp9", "organism": "Rat", "refseq_name": "matrix metalloproteinase-9 precursor", "refseq_ac": [ { "id": "NP_112317", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112317", "type": "external" } ], "gene_names_uniprotkb": "Mmp9", "gene_names_refseq": "Mmp9", "protein_names_uniprotkb": "Matrix metalloproteinase-9; 3.4.24.35; 92 kDa gelatinase; 92 kDa type IV collagenase; GELB; Gelatinase B; MMP-9", "protein_names_refseq": "92 kDa gelatinase; 92-kDa type IV collagenase; GELB; MMP-9; gelatinase B; matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase); matrix metalloproteinase-9 precursor; matrix metalloproteinase-9", "tax_id": 10116, "disease": "pterygium (Disease Ontology:DOID:0002116); sinusitis (Disease Ontology:DOID:0050127); chorioamnionitis (Disease Ontology:DOID:0050697); cardiomyopathy (Disease Ontology:DOID:0050700); primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); rheumatic heart disease (Disease Ontology:DOID:0050827); obstructive sleep apnea (Disease Ontology:DOID:0050848); glomerulosclerosis (Disease Ontology:DOID:0050851); renal fibrosis (Disease Ontology:DOID:0050855); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); stroke (Disease Ontology:DOID:0051061); autism spectrum disorder (Disease Ontology:DOID:0060041); ductal carcinoma in situ (Disease Ontology:DOID:0060074); atrial fibrillation (Disease Ontology:DOID:0060224); thrombosis (Disease Ontology:DOID:0060903); alcohol-associated liver disease (Disease Ontology:DOID:0070658); meningococcal meningitis (Disease Ontology:DOID:0080176); hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); congenital anomalies of the kidney and urinary tract 2 (Disease Ontology:DOID:0080207); polymyositis (Disease Ontology:DOID:0080745); Sweet syndrome (Disease Ontology:DOID:0080746); Sturge-Weber syndrome (Disease Ontology:DOID:0111563); pigmentation disease (Disease Ontology:DOID:10123); dermatomyositis (Disease Ontology:DOID:10223); stomach cancer (Disease Ontology:DOID:10534); adrenoleukodystrophy (Disease Ontology:DOID:10588); pre-eclampsia (Disease Ontology:DOID:10591); pleural tuberculosis (Disease Ontology:DOID:106); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); intracranial aneurysm (Disease Ontology:DOID:10941); cholesteatoma of middle ear (Disease Ontology:DOID:10964); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); arteriovenous malformation (Disease Ontology:DOID:11294); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); familial hyperlipidemia (Disease Ontology:DOID:1168); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); primary biliary cholangitis (Disease Ontology:DOID:12236); retinal ischemia (Disease Ontology:DOID:12510); Huntington's disease (Disease Ontology:DOID:12858); Sjogren's syndrome (Disease Ontology:DOID:12894); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); crescentic glomerulonephritis (Disease Ontology:DOID:13139); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); Kawasaki disease (Disease Ontology:DOID:13378); tuberous sclerosis (Disease Ontology:DOID:13515); angle-closure glaucoma (Disease Ontology:DOID:13550); anodontia (Disease Ontology:DOID:13714); familial hypercholesterolemia (Disease Ontology:DOID:13810); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Down syndrome (Disease Ontology:DOID:14250); fragile X syndrome (Disease Ontology:DOID:14261); cystic fibrosis (Disease Ontology:DOID:1485); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); ventricular septal defect (Disease Ontology:DOID:1657); glaucoma (Disease Ontology:DOID:1686); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); childhood absence epilepsy (Disease Ontology:DOID:1825); epilepsy (Disease Ontology:DOID:1826); focal epilepsy (Disease Ontology:DOID:2234); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); colon adenocarcinoma (Disease Ontology:DOID:234); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); Takayasu's arteritis (Disease Ontology:DOID:2508); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); endometrial carcinoma (Disease Ontology:DOID:2871); endometriosis (Disease Ontology:DOID:289); allergic contact dermatitis (Disease Ontology:DOID:3042); glioblastoma (Disease Ontology:DOID:3068); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); temporal lobe epilepsy (Disease Ontology:DOID:3328); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); heart valve disease (Disease Ontology:DOID:4079); systemic scleroderma (Disease Ontology:DOID:418); hyperglycemia (Disease Ontology:DOID:4195); conjunctivochalasis (Disease Ontology:DOID:4250); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); epidermolysis bullosa simplex (Disease Ontology:DOID:4644); brain edema (Disease Ontology:DOID:4724); esophagus adenocarcinoma (Disease Ontology:DOID:4914); cholangiocarcinoma (Disease Ontology:DOID:4947); chronic inflammatory demyelinating polyradiculoneuropathy (Disease Ontology:DOID:5213); stomach carcinoma (Disease Ontology:DOID:5517); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); viral encephalitis (Disease Ontology:DOID:646); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); varicose veins (Disease Ontology:DOID:799); osteoarthritis (Disease Ontology:DOID:8398); ileus (Disease Ontology:DOID:8440); lung disease (Disease Ontology:DOID:850); chronic ulcer of skin (Disease Ontology:DOID:8549); pyoderma gangrenosum (Disease Ontology:DOID:8553); cholesteatoma (Disease Ontology:DOID:869); bacterial pneumonia (Disease Ontology:DOID:874); neuromyelitis optica (Disease Ontology:DOID:8869); rosacea (Disease Ontology:DOID:8881); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); colorectal cancer (Disease Ontology:DOID:9256); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); bacterial meningitis (Disease Ontology:DOID:9470); pulmonary embolism (Disease Ontology:DOID:9477); bronchiectasis (Disease Ontology:DOID:9563); pulmonary emphysema (Disease Ontology:DOID:9675); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:81687); (R-RNO-1433557); (R-RNO-1442490); (R-RNO-1474228); (R-RNO-1592389); (R-RNO-2022090); (R-RNO-3928665); (R-RNO-6798695); (R-RNO-9009391)", "pathway_count": 9, "publication_count": 7, "publication_id_list": "38043722;38321559;38501247;38811382;39169203;7590350;8605986", "class_list": "", "function": "Effect of huankuile on colon injury in rats with ulcerative colitis by reducing TNF-alpha and MMP9. Publication Status: Online-Only, [RefSeq, PubMed]; JNK2-MMP-9 axis facilitates the progression of intracranial aneurysms. Erratum:[Sci Rep. 2025 Sep 18;15(1):32593. doi: 10.1038/s41598-025-17846-w. PMID: 40968147] Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown the moyamoya disease susceptibility gene, RNF213, upregulates the expression of basic fibroblast growth factor and matrix metalloproteinase-9 in bone marrow derived mesenchymal stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; LOX-1 and MMP-9 Inhibition Attenuates the Detrimental Effects of Delayed rt-PA Therapy and Improves Outcomes After Acute Ischemic Stroke., [RefSeq, PubMed]; Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (By similarity). Could play a role in bone osteoclastic resorption (By similarity). Cleaves KiSS1 at a Gly-|-Leu bond (By similarity). Cleaves NINJ1 to generate the Secreted ninjurin-1 form (By similarity). Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mechanism of pro-MMP9 activation in co-culture of pro-inflammatory macrophages and cardiomyocytes., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 2, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 136, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.24.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.21.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.1", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.21.39", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.39", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0032991 protein-containing complex;GO:0099092 postsynaptic density, intracellular component", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0006508 proteolysis;GO:0006979 response to oxidative stress;GO:0007507 heart development;GO:0007584 response to nutrient", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P50282-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30560-1", "uniprot_id": [ { "id": "V1AR_RAT", "url": "https://www.uniprot.org/uniprot/P30560", "type": "external" } ], "mass": 47655.0, "length": 424, "protein_name": "Vasopressin V1a receptor", "gene_name": "Avpr1a", "organism": "Rat", "refseq_name": "vasopressin V1a receptor", "refseq_ac": [ { "id": "NP_444178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444178", "type": "external" } ], "gene_names_uniprotkb": "Avpr1a", "gene_names_refseq": "AVPR; Avpr1a; V1aR; V1a", "protein_names_uniprotkb": "Vasopressin V1a receptor; AVPR V1a; Antidiuretic hormone receptor 1a; V1aR; Vascular/hepatic-type arginine vasopressin receptor", "protein_names_refseq": "antidiuretic hormone receptor 1a; arginine vasopressin receptor V1a; vascular/hepatic-type arginine vasopressin receptor; vasopressin V1a receptor", "tax_id": 10116, "disease": "Schmid metaphyseal chondrodysplasia (Disease Ontology:DOID:0080021); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); renovascular hypertension (Disease Ontology:DOID:1591); osteochondrodysplasia (Disease Ontology:DOID:2256); acute kidney failure (Disease Ontology:DOID:3021); lung adenocarcinoma (Disease Ontology:DOID:3910); brain edema (Disease Ontology:DOID:4724); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (rno:25107); (R-RNO-388479); (R-RNO-416476)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "11466323;11520055;12399435;12887422;1560825;30071278;32415179;33264070;34445168;35661787;7774575;8257445;8511367;8670090;9105680", "class_list": "", "function": "Co-Stimulation of Oxytocin and Arginine-Vasopressin Receptors Affect Hypothalamic Neurospheroid Size. Publication Status: Online-Only, [RefSeq, PubMed]; Findings suggest that forebrain oxytocin receptor and vasopressin 1a are down-regulated in response to chronic oxytocin treatment., [RefSeq, PubMed]; Paraventricular Nucleus V1a Receptor Knockdown Blunts Neurocardiovascular Responses to Acute Stress in Male Rats after Chronic Mild Unpredictable Stress., [RefSeq, PubMed]; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system., [UniProtKB, UniProtKB, UniProtKB, PubMed]; This gene encodes a receptor for arginine vasopressin, a neurohypophyseal hormone involved in diuresis inhibition, smooth muscle contraction, liver glycogenolysis stimulation and regulation of adrenocorticotropic hormone release from the pituitary. This receptor represents one of three G protein-coupled arginine vasopressin receptors which functions through a phosphotidylinositol-calcium second messenger system in vascular and hepatic tissues. [provided by RefSeq, Jul 2008]., [RefSeq]; V1a and V1b vasopressin receptors within the paraventricular nucleus contribute to hypertension in male rats exposed to chronic mild unpredictable stress., [RefSeq, PubMed]; Vasopressin and v1br gene expression is increased in the hypothalamic pvn of borderline hypertensive rats., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5M8D1;Q62874;Q9QW18", "ec_number_list": [], "go_molecular_function": "GO:0031894 V1A vasopressin receptor binding;GO:0017046 peptide hormone binding;GO:0005000 vasopressin receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0045819 positive regulation of glycogen catabolic process;GO:0051970 negative regulation of transmission of nerve impulse;GO:0002125 maternal aggressive behavior;GO:0007621 negative regulation of female receptivity;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P30560-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BNF1-1", "uniprot_id": [ { "id": "SEPT8_RAT", "url": "https://www.uniprot.org/uniprot/B0BNF1", "type": "external" } ], "mass": 51252.0, "length": 442, "protein_name": "Septin-8", "gene_name": "Septin8", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Septin8; Sept8", "gene_names_refseq": "", "protein_names_uniprotkb": "Septin-8", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:303135)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15485874;19196426;22673903", "class_list": "", "function": "Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (By similarity). Seems to participate in the process of SNARE complex formation in synaptic vesicles (PubMed:19196426)., [UniProtKB, UniProtKB, PubMed]; Filament-forming cytoskeletal GTPase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005940 septin ring;GO:0030424 axon;GO:0043209 myelin sheath;GO:0015630 microtubule cytoskeleton;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0035542 regulation of SNARE complex assembly;GO:0031647 regulation of protein stability;GO:0008104 intracellular protein localization;GO:0033157 regulation of intracellular protein transport;GO:0061640 cytoskeleton-dependent cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B0BNF1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08876-1", "uniprot_id": [ { "id": "KLF10_RAT", "url": "https://www.uniprot.org/uniprot/O08876", "type": "external" } ], "mass": 51829.0, "length": 480, "protein_name": "Krueppel-like factor 10", "gene_name": "Klf10", "organism": "Rat", "refseq_name": "Krueppel-like factor 10", "refseq_ac": [ { "id": "NP_112397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112397", "type": "external" } ], "gene_names_uniprotkb": "Klf10; Cpg20; Tieg1; Tieg", "gene_names_refseq": "Klf10; Tieg", "protein_names_uniprotkb": "Krueppel-like factor 10; TGFB-inducible early growth response protein 1; TIEG-1; Transforming growth factor-beta-inducible early growth response protein 1; Zinc finger transcription factor homolog CPG20", "protein_names_refseq": "Krueppel-like factor 10; Kruppel-like factor 10; TGFB inducible early growth response; TGFB-inducible early growth response protein 1; TIEG-1; transforming growth factor-beta-inducible early growth response protein 1; zinc finger transcription factor homolog CPG20", "tax_id": 10116, "disease": "", "pathway": " (rno:81813)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20070857;20155803;21856285;25448845;26252173;9699150", "class_list": "", "function": "A novel role for TIEG1 was determined as an inhibitor in angiotensin II-induced cardiomyocyte hypertrophy., [RefSeq, PubMed]; Our results identify Tieg1/Klf10 as a new NGF target gene and substantiate its anti-proliferative function in the NGF signaling pathway in PC12 cells, [RefSeq, PubMed]; TGFbeta2 regulates hypothalamic TRH expression through TIEG1 during fetal development., [RefSeq, PubMed]; These data suggest that crosstalk between ChREBP and KLF-10 is involved in the regulation of the lipogenic pathway., [RefSeq, PubMed]; Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. May play a role in the cell cycle regulation (By similarity). Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4QRA4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0001046 core promoter sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1990859 cellular response to endothelin;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O08876-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05544-1", "uniprot_id": [ { "id": "SPA3L_RAT", "url": "https://www.uniprot.org/uniprot/P05544", "type": "external" } ], "mass": 46277.0, "length": 413, "protein_name": "Serine protease inhibitor A3L", "gene_name": "Serpina3a; Serpina3j; Serpina3l; Serpina3n", "organism": "Rat", "refseq_name": "serine protease inhibitor A3L precursor", "refseq_ac": [ { "id": "NP_001376144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376144", "type": "external" } ], "gene_names_uniprotkb": "Serpina3a; Serpina3j; Serpina3l; Serpina3n; LOC100909605; LOC299277; LOC299282; Serpina3a; Serpina3n; Spin2a", "gene_names_refseq": "Ab1-021; CPi-23; SPI1; Serpina3l; Spin1; Spin2a", "protein_names_uniprotkb": "Serine protease inhibitor A3L; CPI-23; Contrapsin-like protease inhibitor 3; SPI-1; Serine protease inhibitor 1; Serpin A3L", "protein_names_refseq": "SPI-1; SPI-2.1; contrapsin-like protease inhibitor 3; contrapsin-like protease inhibitor-related protein; liver regeneration protein lrryan; serine protease inhibitor 1; serine protease inhibitor 2.1; serine protease inhibitor 2a; serine protease inhibitor A3L precursor; serine protease inhibitor A3L; serpin A3L", "tax_id": 10116, "disease": "adult respiratory distress syndrome (Disease Ontology:DOID:11394); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); cystic fibrosis (Disease Ontology:DOID:1485); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung adenocarcinoma (Disease Ontology:DOID:3910); vasculitis (Disease Ontology:DOID:865)", "pathway": " (rno:100909605); (rno:299277); (rno:299282)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "15638460;1694763;1864837;22673903;34502162;3494016", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0034097 response to cytokine", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P05544-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24389-1", "uniprot_id": [ { "id": "IOD1_RAT", "url": "https://www.uniprot.org/uniprot/P24389", "type": "external" } ], "mass": 29730.0, "length": 257, "protein_name": "Type I iodothyronine deiodinase", "gene_name": "Dio1", "organism": "Rat", "refseq_name": "type I iodothyronine deiodinase isoform 2", "refseq_ac": [ { "id": "NP_001311139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001311139", "type": "external" } ], "gene_names_uniprotkb": "Dio1; Itdi1; Txdi1", "gene_names_refseq": "5DI; Dio1; ITDI1; TXDI1", "protein_names_uniprotkb": "Type I iodothyronine deiodinase; 1.21.99.3; 1.21.99.4; 5DI; DIOI; Type 1 DI; Type-I 5'-deiodinase", "protein_names_refseq": "DIOI; deiodinase, iodothyronine, type I; thyroxine deiodinase, type I; type 1 DI; type I iodothyronine deiodinase isoform 2; type-I 5'-deiodinase", "tax_id": 10116, "disease": "thyroid gland disease (Disease Ontology:DOID:50)", "pathway": " (rno:25430); (R-RNO-350864)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11089566;1517238;16230777;1825132;2040632;25874614;33746903;34137693;34195279;4006868;7744884;8187873", "class_list": "", "function": "Adaptive Thermogenesis Driving Catch-Up Fat Is Associated With Increased Muscle Type 3 and Decreased Hepatic Type 1 Iodothyronine Deiodinase Activities: A Functional and Proteomic Study. Publication Status: Online-Only, [RefSeq, PubMed]; D1 3'UTR may play an important role in regulating the stability and translational efficiency of the D1 mRNA, [RefSeq, PubMed]; Effect of Preeclampsia on Ultrastructure of Thyroid Gland, Hepatic Type 1 Iodothyronine Deiodinase, and Thyroid Hormone Levels in Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Estrogen deficiency impairs the induction of thyroid hormone activating enzyme D1 in the pituitary, and GH release by acute exercise. Also, acute D1 activation is essential for exercise-induced GH response Publication Status: Online-Only, [RefSeq, PubMed]; Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:1517238, PubMed:2040632, PubMed:7744884, PubMed:1825132). Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD) (By similarity). Catalyzes the deiodination of T4 to 3,3',5'-triiodothyronine (rT3), 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine(3-T1) and 3,3'-diiodothyronine (3,3'-T2) to 3-T1 via inner-ring deiodination (IRD) (By similarity). Catalyzes the deiodination of rT3 to 3,3'-T2 via ORD (PubMed:1517238, PubMed:2040632, PubMed:7744884, PubMed:1825132, PubMed:8187873). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine, 3',5'-diiodothyronamine and 3,3'-diiodothyronamine as well as tyrosyl ring deiodinations of 3,5,3'-triiodothyronamine and 3,5-diiodothyronamine (By similarity). Catalyzes the deiodination of T3 and 3,3',5-triiodo-L-thyronine sulfate via IRD (PubMed:8187873). Catalyzes the deiodination of L-thyroxine sulfate via IRD and 3,3',5'-triiodo-L-thyronine sulfate via ORD (PubMed:4006868)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed]; Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine)., [UniProtKB, UniProtKB, UniProtKB]; TGF-beta1 mediates cell proliferation and development of hepatocarcinogenesis by downregulating deiodinase 1 expression.', trans 'La desregulacion de la deiodinasa 1, mediada por TGF-beta1, impulsa la proliferacion celular y el desarrollo de hepatocarcinogenesis., [RefSeq, PubMed]; The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.21.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.21.99.3", "type": "external" }, { "id": "1.21.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.21.99.4", "type": "external" } ], "go_molecular_function": "GO:0033798 thyroxine 5-deiodinase activity;GO:0004800 thyroxine 5'-deiodinase activity;GO:0008430 selenium binding", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042404 thyroid hormone catabolic process;GO:0006091 generation of precursor metabolites and energy;GO:0042446 hormone biosynthetic process;GO:0006520 amino acid metabolic process;GO:0042403 thyroid hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P24389-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09139-1", "uniprot_id": [ { "id": "AGT1_RAT", "url": "https://www.uniprot.org/uniprot/P09139", "type": "external" } ], "mass": 45834.0, "length": 414, "protein_name": "Alanine--glyoxylate aminotransferase", "gene_name": "Agxt", "organism": "Rat", "refseq_name": "serine--pyruvate aminotransferase, peroxisomal isoform 3", "refseq_ac": [ { "id": "NP_001263635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263635", "type": "external" } ], "gene_names_uniprotkb": "Agxt; Agt1", "gene_names_refseq": "AGT; Agxt; SPT; Spat", "protein_names_uniprotkb": "Alanine--glyoxylate aminotransferase; 2.6.1.44; 2.6.1.51; AGT; SPT; Serine--pyruvate aminotransferase, mitochondrial", "protein_names_refseq": "alanine--glyoxylate and serine--pyruvate aminotransferase; angiotensin receptor 2; serine--pyruvate aminotransferase, mitochondrial; serine--pyruvate aminotransferase, peroxisomal isoform 3; serine--pyruvate aminotransferase, peroxisomal; serine-pyruvate aminotransferase; serine:pyruvate aminotransferase SPT; serine:pyruvate/alanine:glyoxylate aminotransferase", "tax_id": 10116, "disease": "autosomal recessive spinocerebellar ataxia 7 (Disease Ontology:DOID:0080059); neuronal ceroid lipofuscinosis 2 (Disease Ontology:DOID:0110726); primary hyperoxaluria type 1 (Disease Ontology:DOID:0111670); primary hyperoxaluria (Disease Ontology:DOID:2977)", "pathway": " (rno:24792); (R-RNO-389661); (R-RNO-9033241)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10347151;2332438;2822418;6725236;8406472", "class_list": "", "function": "Catalyzes the transamination between L-serine and pyruvate and weakly contributes to gluconeogenesis from the L-serine metabolism., [UniProtKB, PubMed]; Catalyzes the transamination of glyoxylate to glycine and contributes to the glyoxylate detoxification., [UniProtKB, UniProtKB]; This gene encodes alanine-glyoxylate aminotransferase, which catalyzes the interconversion of L-alanine and glyoxylate to pyruvate and glycine. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. The longer transcript variant includes an upstream translation start codon and a downstream translation start codon. The upstream start codon initiates the translation of the mitochondrial enzyme precursor while the downstream start codon initiates the translation of the peroxisomal enzyme (see PMID:2332438). [provided by RefSeq, Feb 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R2C7", "ec_number_list": [ { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "2.6.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.40", "type": "external" }, { "id": "2.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.18", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0004760 L-serine-pyruvate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0016597 amino acid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0042866 pyruvate biosynthetic process;GO:0046724 oxalic acid secretion;GO:0007219 Notch signaling pathway;GO:0051384 response to glucocorticoid;GO:0046487 glyoxylate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P09139-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CB49-1", "uniprot_id": [ { "id": "YLPM1_RAT", "url": "https://www.uniprot.org/uniprot/P0CB49", "type": "external" } ], "mass": 154270.0, "length": 1376, "protein_name": "YLP motif-containing protein 1", "gene_name": "Ylpm1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ylpm1; Zap3; Zap", "gene_names_refseq": "", "protein_names_uniprotkb": "YLP motif-containing protein 1; Nuclear protein ZAP3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "14724321;17890166;22673903", "class_list": "", "function": "Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0CB49-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JZ79-1", "uniprot_id": [ { "id": "SIR1_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JZ79", "type": "external" } ], "mass": 80717.0, "length": 741, "protein_name": "NAD-dependent protein deacetylase sirtuin-1", "gene_name": "Sirt1", "organism": "Rat", "refseq_name": "NAD-dependent protein deacetylase sirtuin-1 isoform 1", "refseq_ac": [ { "id": "NP_001401888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401888", "type": "external" } ], "gene_names_uniprotkb": "Sirt1", "gene_names_refseq": "Sir2; Sirt1", "protein_names_uniprotkb": "NAD-dependent protein deacetylase sirtuin-1; 2.3.1.-; 2.3.1.286; NAD-dependent protein deacylase sirtuin-1", "protein_names_refseq": "NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1 isoform 1; NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacylase sirtuin-1; Sir2alpha; sirtuin 1 ((silent mating type information regulation 2, homolog) 1", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); osteoporosis (Disease Ontology:DOID:11476); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); acute kidney failure (Disease Ontology:DOID:3021); middle cerebral artery infarction (Disease Ontology:DOID:3525); macular degeneration (Disease Ontology:DOID:4448); myocardial infarction (Disease Ontology:DOID:5844); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); senile cataract (Disease Ontology:DOID:9669); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:309757); (R-RNO-3371453); (R-RNO-427359); (R-RNO-9617629); (R-RNO-9764725); (R-RNO-9841922); (R-RNO-9856649)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "38300636;38700532;38767771;38904464;39012929;39216234", "class_list": "", "function": "ACTIVATION OF KLOTHO/SIRT1 SIGNALING PATHWAY ATTENUATES MYOCARDIAL ISCHEMIA REPERFUSION INJURY IN DIABETIC RATS., [RefSeq, PubMed]; Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly., [UniProtKB, UniProtKB]; Deacetylation of HnRNP U mediated by sirtuin1 ameliorates aged rat with liver fibrosis via inhibiting p53-related senescence and NLRP3-related inflammation., [RefSeq, PubMed]; NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction. Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Deacetylates 'Lys-266' of SUV39H1, leading to its activation. Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1. Deacetylates H2A and 'Lys-26' of H1-4. Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression. Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting. Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1. Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2. This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response. Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence. Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I. Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability. Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation. Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis. Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing. Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF. Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1. Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver. Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation. Involved in HES1- and HEY2-mediated transcriptional repression. In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62'. Deacetylates MEF2D. Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3. Represses HNF1A-mediated transcription. Required for the repression of ESRRG by CREBZF. Deacetylates NR1H3 AND NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed. Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis. Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2. Deacetylates p300/EP300 and PRMT1. Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation. Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis. Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression. Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2. Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN. Promotes DNA double-strand breaks by mediating deacetylation of SIRT6. Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage. Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1. Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8. Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation. Acts as a regulator of AMPK activity in response to calorie restriction: deacetylates the ATP6V1E1 subunit of the V-ATPase complex following activation by TULP3, leading to (1) V-ATPase complex inhibition on lysosomes and (2) AMPK activation via the AXIN1-STK11/LKB1 axis. Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear. In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability. Deacetylates MECOM/EVI1. Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization. During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling. Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator. Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome. Protects cardiomyocytes against palmitate-induced apoptosis. Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity. Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis. Involved in the CCAR2-mediated regulation of PCK1 and NR1D1. Deacetylates CTNB1 at 'Lys-49'. In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling. In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein depropionylation and decrotonylation. Mediates depropionylation of Osterix (SP7). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase. Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity. Involved in the regulation of centrosome duplication. Deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (By similarity). Deacetylates NDC80/HEC1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; SIRT1 maintains bone homeostasis by regulating osteoblast glycolysis through GOT1. Publication Status: Online-Only, [RefSeq, PubMed]; SIRT1 restores mitochondrial structure and function in rats by activating SIRT3 after cerebral ischemia/reperfusion injury. Publication Status: Online-Only, [RefSeq, PubMed]; Sirt1 Deficiency Promotes Age-Related AF Through Enhancing Atrial Necroptosis by Activation of RIPK1 Acetylation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8I6A306", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.9.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" } ], "go_molecular_function": "GO:1990254 keratin filament binding;GO:0046970 histone H4K16 deacetylase activity, NAD-dependent;GO:0003713 transcription coactivator activity;GO:0004857 enzyme inhibitor activity;GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0070857 regulation of bile acid biosynthetic process;GO:0090400 stress-induced premature senescence;GO:0000720 pyrimidine dimer repair by nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A0A0G2JZ79-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZTQ1-1", "uniprot_id": [ { "id": "SFSWA_RAT", "url": "https://www.uniprot.org/uniprot/D3ZTQ1", "type": "external" } ], "mass": 104147.0, "length": 945, "protein_name": "Splicing factor, suppressor of white-apricot homolog", "gene_name": "Sfswap", "organism": "Rat", "refseq_name": "splicing factor, suppressor of white-apricot homolog isoform X5", "refseq_ac": [ { "id": "XP_006249333", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006249333", "type": "external" } ], "gene_names_uniprotkb": "Sfswap; Sfrs8; Srsf8; Swap", "gene_names_refseq": "Sfrs8; Sfswap; Srsf8", "protein_names_uniprotkb": "Splicing factor, suppressor of white-apricot homolog; Splicing factor, arginine/serine-rich 8; Suppressor of white apricot protein homolog", "protein_names_refseq": "splicing factor, suppressor of white-apricot homolog isoform X5", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15009664;22673903", "class_list": "", "function": "Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors (By similarity). Represses the splicing of MAPT/Tau exon 10., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5BJQ4", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0000380 alternative mRNA splicing, via spliceosome;GO:0000395 mRNA 5'-splice site recognition;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZTQ1-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16598-1", "uniprot_id": [ { "id": "IL1A_RAT", "url": "https://www.uniprot.org/uniprot/P16598", "type": "external" } ], "mass": 30856.0, "length": 270, "protein_name": "Interleukin-1 alpha", "gene_name": "Il1a", "organism": "Rat", "refseq_name": "interleukin-1 alpha", "refseq_ac": [ { "id": "NP_058715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058715", "type": "external" } ], "gene_names_uniprotkb": "Il1a", "gene_names_refseq": "IL-1 alpha; IL-1F1; Il1a", "protein_names_uniprotkb": "Interleukin-1 alpha; IL-1 alpha", "protein_names_refseq": "interleukin-1 alpha", "tax_id": 10116, "disease": "aspiration pneumonia (Disease Ontology:DOID:0050152); X-linked dyskeratosis congenita (Disease Ontology:DOID:0070025); urinary tract infection (Disease Ontology:DOID:0080784); Graves ophthalmopathy (Disease Ontology:DOID:0081120); graft-versus-host disease (Disease Ontology:DOID:0081267); endometritis (Disease Ontology:DOID:1002); keratoconus (Disease Ontology:DOID:10126); common cold (Disease Ontology:DOID:10459); Alzheimer's disease (Disease Ontology:DOID:10652); otitis media (Disease Ontology:DOID:10754); cholesteatoma of middle ear (Disease Ontology:DOID:10964); corneal edema (Disease Ontology:DOID:11030); osteoporosis (Disease Ontology:DOID:11476); beta thalassemia (Disease Ontology:DOID:12241); vitiligo (Disease Ontology:DOID:12306); varicocele (Disease Ontology:DOID:12337); aplastic anemia (Disease Ontology:DOID:12449); uveitis (Disease Ontology:DOID:13141); cholestasis (Disease Ontology:DOID:13580); Fabry disease (Disease Ontology:DOID:14499); cystic fibrosis (Disease Ontology:DOID:1485); pancreatic cancer (Disease Ontology:DOID:1793); dyskeratosis congenita (Disease Ontology:DOID:2729); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); Schnitzler syndrome (Disease Ontology:DOID:4371); pneumonia (Disease Ontology:DOID:552); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); periodontitis (Disease Ontology:DOID:824); osteoarthritis (Disease Ontology:DOID:8398); lung disease (Disease Ontology:DOID:850); cholesteatoma (Disease Ontology:DOID:869); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); diabetic retinopathy (Disease Ontology:DOID:8947); acute myeloid leukemia (Disease Ontology:DOID:9119); iridocyclitis (Disease Ontology:DOID:9383); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24493); (R-RNO-448706); (R-RNO-5620971); (R-RNO-9020702)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "2471704;31172560;32920036;33106949;33107399;34047944", "class_list": "", "function": "Activated microglia-derived macrophage-like cells exacerbate brain edema after ischemic stroke correlate with astrocytic expression of aquaporin-4 and interleukin-1 alpha release., [RefSeq, PubMed]; Bioinformatics-based Identification of Key Pathways and Hub Genes of Traumatic Brain Injury in a Rat Model., [RefSeq, PubMed]; Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity., [UniProtKB, UniProtKB]; Hypothyroidism Induces Interleukin-1-Dependent Autophagy Mechanism as a Key Mediator of Hippocampal Neuronal Apoptosis and Cognitive Decline in Postnatal Rats., [RefSeq, PubMed]; IL-1alpha Regulates Osteogenesis and Osteoclastic Activity of Dental Follicle Cells Through JNK and p38 MAPK Pathways., [RefSeq, PubMed]; Silencing interleukin 1alpha underlies a novel inhibitory role of miR-181c-5p in alleviating low-grade inflammation of rats with irritable bowel syndrome., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 43, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q546R9", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005507 copper ion binding;GO:0005149 interleukin-1 receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0009986 cell surface", "go_biological_process": "GO:0033092 positive regulation of immature T cell proliferation in thymus;GO:0001660 fever generation;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P16598-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17491-1", "uniprot_id": [ { "id": "INHBB_RAT", "url": "https://www.uniprot.org/uniprot/P17491", "type": "external" } ], "mass": 45183.0, "length": 411, "protein_name": "Inhibin beta B chain", "gene_name": "Inhbb", "organism": "Rat", "refseq_name": "inhibin beta B chain precursor", "refseq_ac": [ { "id": "NP_542949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542949", "type": "external" } ], "gene_names_uniprotkb": "Inhbb", "gene_names_refseq": "Inhbb", "protein_names_uniprotkb": "Inhibin beta B chain; Activin beta-B chain", "protein_names_refseq": "activin beta-B chain; activin betaB; inhibin beta B chain precursor; inhibin beta B chain; inhibin beta B subunit; inhibin beta subunit B; inhibin beta-B", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328)", "pathway": " (rno:25196); (R-RNO-1502540); (R-RNO-209822); (R-RNO-2473224)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "12729472;2484214;2628729;27620967;27693126;27922109;8033818", "class_list": "", "function": "Activin B induced phosphorylation and activation of Smad1/5/8, the BMP-regulated (BR)-Smads. The stimulation of hepcidin transcription by activin B was mediated by ALK2 and ActRIIA, receptors for the TGF-beta family. Publication Status: Online-Only, [RefSeq, PubMed]; Activin B is a dimer of alpha and beta-B that plays a role in several essential biological processes including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and wound healing. Signals through type I receptor ACVR1C, abundantly expressed in pancreatic beta cells, and type II receptors like ACVR2A. Upon ligand binding, these receptors phosphorylate intracellular signaling mediators SMAD2 and SMAD3, which form a complex with SMAD4, translocate to the nucleus, and regulate gene expression. Plays a crucial role in the induction of hepcidin by inflammation through activation of ACVR1C and subsequent phosphorylation of SMAD1/5/8. Regulates adipocyte lipid metabolism by decreasing non-esterified fatty acids and glycerol release and increases intracellular triglyceride content. Stimulates wound healing by promoting cell migration and hair follicle regeneration through the JNK and ERK signaling pathways downstream of RHOA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Inhibin B is a dimer of alpha and beta-B that plays a crucial role in the regulation of the reproductive system by inhibiting the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Thereby, maintains reproductive homeostasis in both males and females. Acts as a more potent suppressor of FSH release than inhibin A. Functions as competitive receptor antagonist binding activin type II receptors with high affinity in the presence of the TGF-beta type III coreceptor/TGFBR3L., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results identified Inhbb as one factor mediating the proliferative effect of Pdx-1 on islet cells. Publication Status: Online-Only, [RefSeq, PubMed]; RhoA regulates Activin B-induced stress fiber formation and migration of Bone marrow-derived mesenchymal stem cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K471", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0048471 perinuclear region of cytoplasm;GO:0071944 cell periphery;GO:0005576 extracellular region", "go_biological_process": "GO:0046882 negative regulation of follicle-stimulating hormone secretion;GO:0060279 positive regulation of ovulation;GO:0007283 spermatogenesis;GO:0032869 cellular response to insulin stimulus;GO:0071320 cellular response to cAMP", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P17491-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08723-1", "uniprot_id": [ { "id": "SPBP_RAT", "url": "https://www.uniprot.org/uniprot/P08723", "type": "external" } ], "mass": 31080.0, "length": 279, "protein_name": "Prostatic spermine-binding protein", "gene_name": "Sbp", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sbp; Zg16b", "gene_names_refseq": "", "protein_names_uniprotkb": "Prostatic spermine-binding protein; SBP", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "3166977;3818623", "class_list": "", "function": "Spermine-binding protein is an androgen regulated ventral prostate glycoprotein that binds various polyamines., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0019808 polyamine binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P08723-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31643-1", "uniprot_id": [ { "id": "SC6A6_RAT", "url": "https://www.uniprot.org/uniprot/P31643", "type": "external" } ], "mass": 69869.0, "length": 621, "protein_name": "Sodium- and chloride-dependent taurine transporter", "gene_name": "Slc6a6", "organism": "Rat", "refseq_name": "sodium- and chloride-dependent taurine transporter", "refseq_ac": [ { "id": "NP_058902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058902", "type": "external" } ], "gene_names_uniprotkb": "Slc6a6", "gene_names_refseq": "Slc6a6; TauT", "protein_names_uniprotkb": "Sodium- and chloride-dependent taurine transporter; Solute carrier family 6 member 6; TauT; Taurine transporter", "protein_names_refseq": "Solute carrier 6, member 6 (taurine transporter); sodium- and chloride-dependent taurine transporter; solute carrier family 6 (neurotransmitter transporter), member 6; solute carrier family 6 (neurotransmitter transporter, taurine), member 6; taurine/beta-alanine transporter", "tax_id": 10116, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584); multiple system atrophy (Disease Ontology:DOID:4752)", "pathway": " (rno:29464); (R-RNO-352230)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1435737;18501699;22896705;29491210", "class_list": "", "function": "Mediates sodium- and chloride-dependent transport of taurine, a key amino acid (PubMed:1435737, PubMed:18501699, PubMed:22896705). Taurine acts as an anti-aging agent by reducing cellular senescence and combating oxidative stress: levels decline with age and supplementation has been shown to extend lifespan (By similarity). In addition to mediate extracellular taurine uptake, also able to mediate transport of taurine into mitochondria, sustaining mitochondrial translation (By similarity). Can also mediate transport of beta-alanine, hypotaurine and gamma-aminobutyric acid (GABA) (PubMed:18501699)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]; The purpose of this study was to clarify the assembly of taurine transporter (TauT/Slc6a6) and PSD-95/Disc-large/Zo-1 (PDZ) domain of Na(+)-H(+) exchanger regulatory factor 1 as a regulatory mechanism of Slc6a6-mediated GABA transport activity, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030977 taurine binding;GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0005283 amino acid:sodium symporter activity;GO:0005369 taurine:sodium symporter activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0032328 alanine transport;GO:0045597 positive regulation of cell differentiation;GO:0006865 amino acid transport;GO:0050804 modulation of chemical synaptic transmission;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P31643-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GV24-1", "uniprot_id": [ { "id": "UFL1_RAT", "url": "https://www.uniprot.org/uniprot/B2GV24", "type": "external" } ], "mass": 89585.0, "length": 793, "protein_name": "E3 UFM1-protein ligase 1", "gene_name": "Ufl1", "organism": "Rat", "refseq_name": "E3 UFM1-protein ligase 1", "refseq_ac": [ { "id": "NP_001119751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119751", "type": "external" } ], "gene_names_uniprotkb": "Ufl1; Maxer; Rcad", "gene_names_refseq": "Maxer; RGD1309308; Ufl1", "protein_names_uniprotkb": "E3 UFM1-protein ligase 1; 2.3.2.-; E3 UFM1-protein transferase 1; Multiple alpha-helix protein located at ER; Regulator of C53/LZAP and DDRGK1", "protein_names_refseq": "E3 UFM1-protein ligase 1; E3 UFM1-protein transferase 1; multiple alpha-helix protein located at ER; regulator of C53/LZAP and DDRGK1", "tax_id": 10116, "disease": "", "pathway": " (rno:313115); (R-RNO-983168)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "20228063;20531390;22673903", "class_list": "", "function": "E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (By similarity). Catalyzes ufmylation of many protein, such as CD274/PD-L1, CDK5RAP3, CYB5R3, DDRGK1, EIF6, histone H4, MRE11, P4HB, PDCD1/PD-1, TRIP4, RPN1, RPS20/uS10, RPL10/uL16, RPL26/uL24, SYVN1/HRD1 and TP53/p53 (By similarity). As part of the UREL complex, plays a key role in ribosome recycling by catalyzing mono-ufmylation of RPL26/uL24 subunit of the 60S ribosome (By similarity). Ufmylation of RPL26/uL24 occurs on free 60S ribosomes following ribosome dissociation: it weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane (By similarity). Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum (By similarity). Involved in reticulophagy in response to endoplasmic reticulum stress by mediating ufmylation of proteins such as CYB5R3 and RPN1, thereby promoting lysosomal degradation of ufmylated proteins (By similarity). Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response (By similarity). Mediates ufmylation of DDRGK1 and CDK5RAP3; the role of these modifications is however unclear: as both DDRGK1 and CDK5RAP3 act as substrate adapters for ufmylation, it is uncertain whether ufmylation of these proteins is, a collateral effect or is required for ufmylation (By similarity). Acts as a negative regulator of T-cell activation by mediating ufmylation and stabilization of PDCD1/PD-1 (By similarity). Also involved in the response to DNA damage: recruited to double-strand break sites following DNA damage and mediates monoufmylation of histone H4 and ufmylation of MRE11 (By similarity). Mediates ufmylation of TP53/p53, promoting its stability (By similarity). Catalyzes ufmylation of TRIP4, thereby playing a role in nuclear receptor-mediated transcription (By similarity). Required for hematopoietic stem cell function and hematopoiesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results identify a novel molecule named multiple alpha-helix protein located at ER (Maxer) downregulated by mutant ataxin-1 (Atx1) in Bergmann glia., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0071568 UFM1 transferase activity;GO:0019901 protein kinase binding;GO:0061666 UFM1 ligase activity", "go_cellular_component": "GO:1990234 transferase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0060252 positive regulation of glial cell proliferation;GO:0006281 DNA repair;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B2GV24-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19629-1", "uniprot_id": [ { "id": "LDHC_RAT", "url": "https://www.uniprot.org/uniprot/P19629", "type": "external" } ], "mass": 35687.0, "length": 332, "protein_name": "L-lactate dehydrogenase C chain", "gene_name": "Ldhc", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ldhc; Ldh-3; Ldh3", "gene_names_refseq": "", "protein_names_uniprotkb": "L-lactate dehydrogenase C chain; 1.1.1.27; LDH testis subunit; LDH-C; LDH-X", "protein_names_refseq": "", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667)", "pathway": " (R-RNO-70268)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;6343385;7937776", "class_list": "", "function": "Possible role in sperm motility., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.27", "type": "external" } ], "go_molecular_function": "GO:0051287 NAD binding;GO:0004459 L-lactate dehydrogenase (NAD+) activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005929 cilium;GO:0031514 motile cilium", "go_biological_process": "GO:0006754 ATP biosynthetic process;GO:0030317 flagellated sperm motility;GO:0019674 NAD+ metabolic process;GO:0019244 lactate biosynthetic process from pyruvate;GO:0006089 lactate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P19629-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23739-1", "uniprot_id": [ { "id": "SUIS_RAT", "url": "https://www.uniprot.org/uniprot/P23739", "type": "external" } ], "mass": 210350.0, "length": 1841, "protein_name": "Sucrase-isomaltase, intestinal", "gene_name": "Si", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Si", "gene_names_refseq": "", "protein_names_uniprotkb": "Sucrase-isomaltase, intestinal", "protein_names_refseq": "", "tax_id": 10116, "disease": "colitis (Disease Ontology:DOID:0060180); developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425); congenital sucrase-isomaltase deficiency (Disease Ontology:DOID:0111633); alcoholic hepatitis (Disease Ontology:DOID:12351); exocrine pancreatic insufficiency (Disease Ontology:DOID:13316)", "pathway": " (R-RNO-189085)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "2268340;2400788;27480812;29393594;6802834;7821806;8410378", "class_list": "glycogene;glycosylhydrolase", "function": "Bifunctional enzyme with both sucrase and isomaltase activities involved in breakdown of dietary starch oligosaccharides in small intestine. The isomaltase domain hydrolazes alpha-1,6-glycosidic linkages in isomaltose. The sucrase domain cleaves the alpha-1,2-glycosidic linkages in sucrose to form glucose and fructose, and contributes to the cleavage of the alpha-1,4-glycosidic linkage in maltose to form two glucose monosaccharides., [UniProtKB, PubMed]; Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 20, "predicted_n_glycosites": 16, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.10", "type": "external" }, { "id": "3.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.48", "type": "external" } ], "go_molecular_function": "GO:0004558 alpha-1,4-glucosidase activity;GO:0030246 carbohydrate binding;GO:0004574 oligo-1,6-glucosidase activity;GO:0004575 sucrose alpha-glucosidase activity;GO:0004564 beta-fructofuranosidase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005903 brush border;GO:0016020 membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0060574 intestinal epithelial cell maturation;GO:0007584 response to nutrient;GO:0042594 response to starvation;GO:0032094 response to food;GO:0051384 response to glucocorticoid", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P23739-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000001000.0000000011001.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88850-1", "uniprot_id": [ { "id": "HIPK3_RAT", "url": "https://www.uniprot.org/uniprot/O88850", "type": "external" } ], "mass": 129744.0, "length": 1191, "protein_name": "Homeodomain-interacting protein kinase 3", "gene_name": "Hipk3", "organism": "Rat", "refseq_name": "homeodomain-interacting protein kinase 3 isoform 1", "refseq_ac": [ { "id": "NP_113975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113975", "type": "external" } ], "gene_names_uniprotkb": "Hipk3; Fist", "gene_names_refseq": "ANPK; Hipk3", "protein_names_uniprotkb": "Homeodomain-interacting protein kinase 3; 2.7.11.1; ANPK; Androgen receptor-interacting nuclear protein kinase", "protein_names_refseq": "androgen receptor-interacting nuclear protein kinase; homeodomain-interacting protein kinase 3 isoform 1; nuclear serine/threonine protein kinase", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:83617)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "32356246;33660818;37581369;9725910", "class_list": "", "function": "HIPK3 Mediates Inflammatory Cytokines and Oxidative Stress Markers in Monocytes in a Rat Model of Sepsis Through the JNK/c-Jun Signaling Pathway., [RefSeq, PubMed]; MiR-21 attenuates FAS-mediated cardiomyocyte apoptosis by regulating HIPK3 expression., [RefSeq, PubMed]; Overexpression of miR-431 inhibits cardiomyocyte apoptosis following myocardial infarction via targeting HIPK3., [RefSeq, PubMed]; Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0016605 PML body", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0018107 peptidyl-threonine phosphorylation;GO:0018105 peptidyl-serine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88850-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RYN7-1", "uniprot_id": [ { "id": "SPAST_RAT", "url": "https://www.uniprot.org/uniprot/B2RYN7", "type": "external" } ], "mass": 63022.0, "length": 581, "protein_name": "Spastin", "gene_name": "Spast", "organism": "Rat", "refseq_name": "spastin isoform 2", "refseq_ac": [ { "id": "NP_001102172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102172", "type": "external" } ], "gene_names_uniprotkb": "Spast; SPAST; SPG4; Spg4", "gene_names_refseq": "Spast; Spg4", "protein_names_uniprotkb": "Spastin; 5.6.1.1", "protein_names_refseq": "spastic paraplegia 4 (autosomal dominant; spastin isoform 2; spastin)", "tax_id": 10116, "disease": "hereditary spastic paraplegia 4 (Disease Ontology:DOID:0110792); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (rno:362700); (R-RNO-9668328)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "18234839;22673903;25390646;31963385;36587525", "class_list": "", "function": "ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches., [UniProtKB, HAMAP, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; NA14 may act as an adaptor protein regulating SPG4 localization to centrosomes, temporally and spatially regulating the microtubule-severing activity of SPG4 that is particularly critical during the cell cycle and neuronal development. Publication Status: Online-Only, [RefSeq, PubMed]; Rab3A interacts with spastin to regulate neurite outgrowth in hippocampal neurons., [RefSeq, PubMed]; RhoA-GTPase Modulates Neurite Outgrowth by Regulating the Expression of Spastin and p60-Katanin. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" } ], "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0051013 microtubule severing;GO:0031117 positive regulation of microtubule depolymerization;GO:0051260 protein homooligomerization;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B2RYN7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13437-1", "uniprot_id": [ { "id": "THIM_RAT", "url": "https://www.uniprot.org/uniprot/P13437", "type": "external" } ], "mass": 41871.0, "length": 397, "protein_name": "3-ketoacyl-CoA thiolase, mitochondrial", "gene_name": "Acaa2", "organism": "Rat", "refseq_name": "3-ketoacyl-CoA thiolase, mitochondrial", "refseq_ac": [ { "id": "NP_569117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569117", "type": "external" } ], "gene_names_uniprotkb": "Acaa2", "gene_names_refseq": "Acaa2", "protein_names_uniprotkb": "3-ketoacyl-CoA thiolase, mitochondrial; 2.3.1.16; 2.3.1.9; 3.1.2.-; 3.1.2.1; 3.1.2.2; Acetyl-CoA acetyltransferase; Acetyl-CoA acyltransferase; Acyl-CoA hydrolase, mitochondrial; Beta-ketothiolase; Mitochondrial 3-oxoacyl-CoA thiolase", "protein_names_refseq": "3-ketoacyl-CoA thiolase, mitochondrial; acetyl-CoA acetyltransferase; acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase); acyl-CoA hydrolase, mitochondrial; beta-ketothiolase; mitochondrial 3-oxoacyl-CoA thiolase", "tax_id": 10116, "disease": "", "pathway": " (rno:170465); (R-RNO-77289)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16476568;26446791;27213235;3038520;34502162", "class_list": "", "function": "In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs (PubMed:16476568). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" } ], "go_molecular_function": "GO:0003986 acetyl-CoA hydrolase activity;GO:0047617 fatty acyl-CoA hydrolase activity;GO:0003988 acetyl-CoA C-acyltransferase activity;GO:0003985 acetyl-CoA C-acetyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005737 cytoplasm", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0006084 acetyl-CoA metabolic process;GO:0071456 cellular response to hypoxia;GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P13437-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49744-1", "uniprot_id": [ { "id": "TSP4_RAT", "url": "https://www.uniprot.org/uniprot/P49744", "type": "external" } ], "mass": 108214.0, "length": 980, "protein_name": "Thrombospondin-4", "gene_name": "Thbs4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Thbs4; Tsp-4; Tsp4", "gene_names_refseq": "", "protein_names_uniprotkb": "Thrombospondin-4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:29220); (R-RNO-186797)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22745497;23649982;7490284", "class_list": "", "function": "Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix;GO:0031594 neuromuscular junction;GO:0005604 basement membrane", "go_biological_process": "GO:0071603 endothelial cell-cell adhesion;GO:0007399 nervous system development;GO:0048812 neuron projection morphogenesis;GO:0001938 positive regulation of endothelial cell proliferation;GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P49744-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08932-1", "uniprot_id": [ { "id": "KNT2_RAT", "url": "https://www.uniprot.org/uniprot/P08932", "type": "external" } ], "mass": 47704.0, "length": 430, "protein_name": "T-kininogen 2", "gene_name": "Kng1", "organism": "Rat", "refseq_name": "T-kininogen 2 precursor", "refseq_ac": [ { "id": "NP_001009628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009628", "type": "external" } ], "gene_names_uniprotkb": "Kng1; Kng1l1; Kng2", "gene_names_refseq": "Kng1l1; Kng1; kininogen", "protein_names_uniprotkb": "T-kininogen 2; Alpha-1-MAP; Major acute phase protein; T-kininogen II heavy chain; T-kininogen II light chain; T-kininogen II; Thiostatin", "protein_names_refseq": "T-kininogen 2 precursor; T-kininogen 2; kininogen 1-like 1; low molecular weight (LMW) T-kininogen II; major acute phase protein (alpha-1-MAP); thiostatin", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); high molecular weight kininogen deficiency (Disease Ontology:DOID:0111676); IgA vasculitis (Disease Ontology:DOID:11123); hereditary angioedema (Disease Ontology:DOID:14735); abdominal aortic aneurysm (Disease Ontology:DOID:7693); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719)", "pathway": " (rno:288001)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1575697;2413018;2413019;7947964", "class_list": "", "function": "Kininogens are plasma glycoproteins with a number of functions: (1) as precursor of the active peptide bradykinin they effect smooth muscle contraction, induction of hypotension and increase of vascular permeability. (2) They play a role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII. (3) They are inhibitor of thiol proteases., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5M894", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005179 hormone activity;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0006953 acute-phase response;GO:0042311 vasodilation;GO:0030195 negative regulation of blood coagulation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P08932-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B4F7C4-1", "uniprot_id": [ { "id": "TDRD5_RAT", "url": "https://www.uniprot.org/uniprot/B4F7C4", "type": "external" } ], "mass": 111327.0, "length": 995, "protein_name": "Tudor domain-containing protein 5", "gene_name": "Tdrd5", "organism": "Rat", "refseq_name": "tudor domain-containing protein 5", "refseq_ac": [ { "id": "NP_001128212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128212", "type": "external" } ], "gene_names_uniprotkb": "Tdrd5", "gene_names_refseq": "Tdrd5", "protein_names_uniprotkb": "Tudor domain-containing protein 5", "protein_names_refseq": "tudor domain-containing protein 5", "tax_id": 10116, "disease": "", "pathway": " (rno:289129)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the tudor domain-containing protein family. Tudor domain-containing proteins regulate a variety of processes including RNA metabolism, histone modification, and the DNA damage response. The tudor domain commonly functions to link methylated arginine or lysine marks to downstream effector proteins. In mouse, this gene is expressed in the primordial germ cells and in male germ cells during embryogenesis. In addition, it is expressed in adult testis cells where the protein is a component of the intermitochondrial cement and chromatoid bodies. Loss-of-function mutations in mouse result in arrest of spermatogenesis. [provided by RefSeq, Mar 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0045202 synapse;GO:0071546 pi-body;GO:0033391 chromatoid body;GO:0005737 cytoplasm", "go_biological_process": "GO:0030719 P granule organization;GO:0007286 spermatid development;GO:0141196 transposable element silencing by piRNA-mediated DNA methylation;GO:0007283 spermatogenesis;GO:0007281 germ cell development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B4F7C4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08689-1", "uniprot_id": [ { "id": "SHBG_RAT", "url": "https://www.uniprot.org/uniprot/P08689", "type": "external" } ], "mass": 44533.0, "length": 403, "protein_name": "Sex hormone-binding globulin", "gene_name": "Shbg", "organism": "Rat", "refseq_name": "sex hormone-binding globulin isoform a precursor", "refseq_ac": [ { "id": "NP_036782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036782", "type": "external" } ], "gene_names_uniprotkb": "Shbg", "gene_names_refseq": "Abpa; Shbg", "protein_names_uniprotkb": "Sex hormone-binding globulin; ABP; SBP; SHBG; Sex steroid-binding protein; Testis-specific androgen-binding protein", "protein_names_refseq": "ABP; SBP; Sex hormone binding globulin or androgen-binding protein (other gene product from ABP gene); androgen binding protein; sex hormone-binding globulin isoform a precursor; sex steroid-binding protein; testis-specific androgen-binding protein", "tax_id": 10116, "disease": "spinocerebellar ataxia 27A (Disease Ontology:DOID:0050976); spinocerebellar ataxia 27B (Disease Ontology:DOID:0061137); endometrial cancer (Disease Ontology:DOID:1380); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:24775)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "1702422;1855466;21033444;21079794;21734262;2432609;24681170;2840566;3135485;37392803", "class_list": "", "function": "Aging-related increases in serum sex hormone-binding globulin levels in men might be related to increased synthesis., [RefSeq, PubMed]; Data show that the use of alternative SHBG first exons 1A and 1B differentially inhibits translation from the ATG situated in exon 2, which codes for methionine 30 of transcripts that begin with the exon 1 sequence. Publication Status: Online-Only, [RefSeq, PubMed]; Fluorine had no effect on the expression of androgen binding protein and inhibin B mRNA in testis sertoli cells of Sprague Dawley rats., [RefSeq, PubMed]; Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SHBG may be of functional importance for rapid effects of olfactory steroids on limbic functions including the control of reproductive behaviours through pheromones, [RefSeq, PubMed]; Upstream stimulatory factors (USF1 and USF2) induce Nr5a1 and Shbg gene expression during the onset of rat Sertoli cell differentiation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4QR94;Q63029", "ec_number_list": [], "go_molecular_function": "GO:0005497 androgen binding;GO:0005496 steroid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007285 primary spermatocyte growth", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P08689-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RZC4-1", "uniprot_id": [ { "id": "MS18A_RAT", "url": "https://www.uniprot.org/uniprot/B2RZC4", "type": "external" } ], "mass": 25216.0, "length": 223, "protein_name": "Protein Mis18-alpha", "gene_name": "Mis18a", "organism": "Rat", "refseq_name": "protein Mis18-alpha", "refseq_ac": [ { "id": "NP_001120995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120995", "type": "external" } ], "gene_names_uniprotkb": "Mis18a", "gene_names_refseq": "Mis18a; RGD1310778", "protein_names_uniprotkb": "Protein Mis18-alpha", "protein_names_refseq": "protein Mis18-alpha", "tax_id": 10116, "disease": "", "pathway": " (rno:288272); (R-RNO-606279)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin;GO:0098654 CENP-A recruiting complex", "go_biological_process": "GO:0071459 protein localization to chromosome, centromeric region;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0034080 CENP-A containing chromatin assembly;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RZC4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZX08-1", "uniprot_id": [ { "id": "SYAM_RAT", "url": "https://www.uniprot.org/uniprot/D3ZX08", "type": "external" } ], "mass": 107806.0, "length": 985, "protein_name": "Alanine--tRNA ligase, mitochondrial", "gene_name": "Aars2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Aars2; AARS", "gene_names_refseq": "", "protein_names_uniprotkb": "Alanine--tRNA ligase, mitochondrial; 6.-.-.-; 6.1.1.7; AlaRS; Alanyl-tRNA synthetase; Protein lactyltransferase AARS2", "protein_names_refseq": "", "tax_id": 10116, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); progressive leukoencephalopathy with ovarian failure (Disease Ontology:DOID:0070396); combined oxidative phosphorylation deficiency 8 (Disease Ontology:DOID:0111479); dermatomyositis (Disease Ontology:DOID:10223); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); microcephaly (Disease Ontology:DOID:10907); axonal neuropathy (Disease Ontology:DOID:7319)", "pathway": " (rno:301254)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as CGAS. Acts as an inhibitor of cGAS/STING signaling by catalyzing lactylation of CGAS, preventing the formation of liquid-like droplets in which CGAS is activated., [UniProtKB, UniProtKB, UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.7", "type": "external" }, { "id": "6.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0000049 tRNA binding;GO:0004813 alanine-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005737 cytoplasm", "go_biological_process": "GO:0070143 mitochondrial alanyl-tRNA aminoacylation;GO:0160049 negative regulation of cGAS/STING signaling pathway;GO:0006419 alanyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZX08-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VCW5-1", "uniprot_id": [ { "id": "S38A5_RAT", "url": "https://www.uniprot.org/uniprot/A2VCW5", "type": "external" } ], "mass": 52436.0, "length": 479, "protein_name": "Sodium-coupled neutral amino acid transporter 5", "gene_name": "Slc38a5", "organism": "Rat", "refseq_name": "sodium-coupled neutral amino acid transporter 5 isoform 1", "refseq_ac": [ { "id": "NP_001418625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001418625", "type": "external" } ], "gene_names_uniprotkb": "Slc38a5; Sn2; Snat5", "gene_names_refseq": "SN2; Slc38a5", "protein_names_uniprotkb": "Sodium-coupled neutral amino acid transporter 5; Solute carrier family 38 member 5; System N transporter 2", "protein_names_refseq": "amino acid transporter system N2; sodium-coupled neutral amino acid transporter 5 isoform 1; sodium-coupled neutral amino acid transporter 5; system N transporter 2", "tax_id": 10116, "disease": "", "pathway": " (rno:192208); (R-RNO-352230)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11698233;15218073;15390093;16249471;16629640;20036385;22821889;24333324", "class_list": "", "function": "PH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity allosteric regulation involves a conserved histidine residue, [RefSeq, PubMed]; SN2 doubles as a transmitter precursor furnisher and a potential regulator of NMDA receptors., [RefSeq, PubMed]; SNAT5/SN2 expression is coordinated with that of other proteins necessary for the operation of glutamatergic synapses, [RefSeq, PubMed]; Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:11698233, PubMed:15218073, PubMed:16249471, PubMed:16629640, PubMed:22821889). Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-glutamine cycle and the NMDA receptors activation (PubMed:22821889). In addition contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells and, therefore participates in the retinal glutamate-glutamine cycle (PubMed:16249471). The transport activity is pH sensitive (PubMed:22821889, PubMed:15218073, PubMed:11698233), Li(+) tolerant (PubMed:22821889, PubMed:15218073, PubMed:11698233), bidirectional (PubMed:22821889, PubMed:15218073) and associated with large uncoupled fluxes of protons (PubMed:11698233, PubMed:15218073, PubMed:22821889). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (PubMed:22821889). May have particular importance for modulation of net hepatic glutamine flux (PubMed:15218073)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The effect of lipopolysaccharides on system N expression occurs not only at the protein level, but also at the mRNA level, [RefSeq, PubMed]; This transporter is likely to be involved in glutamatergic pathways in the brain., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91XR7", "ec_number_list": [], "go_molecular_function": "GO:0015187 glycine transmembrane transporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015186 L-glutamine transmembrane transporter activity;GO:0015194 L-serine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0015816 glycine transport;GO:0032329 serine transport;GO:1903713 asparagine transmembrane transport;GO:1904557 L-alanine transmembrane transport;GO:0015825 L-serine transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A2VCW5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14562-1", "uniprot_id": [ { "id": "LAMP1_RAT", "url": "https://www.uniprot.org/uniprot/P14562", "type": "external" } ], "mass": 43969.0, "length": 407, "protein_name": "Lysosome-associated membrane glycoprotein 1", "gene_name": "Lamp1", "organism": "Rat", "refseq_name": "lysosome-associated membrane glycoprotein 1 precursor", "refseq_ac": [ { "id": "NP_036989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036989", "type": "external" } ], "gene_names_uniprotkb": "Lamp1; Lamp-1", "gene_names_refseq": "LGP120; Lamp1", "protein_names_uniprotkb": "Lysosome-associated membrane glycoprotein 1; 120 kDa lysosomal membrane glycoprotein; CD107 antigen-like family member A; LAMP-1; LGP-120; Lysosome-associated membrane protein 1", "protein_names_refseq": "120 kDa lysosomal membrane glycoprotein; CD107 antigen-like family member A; LAMP-1; LGP-120; Lysosomal associated membrane protein 1 (120 kDa); lysosomal membrane glycoprotein 1; lysosomal-associated membrane protein 1; lysosome-associated membrane glycoprotein 1 precursor; lysosome-associated membrane glycoprotein 1", "tax_id": 10116, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (rno:25328); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "2920835;29273596;30922709;3174652;38843836", "class_list": "", "function": "Dihydrolipoic acid (DHLA) treatment improved neurofunction and alleviated inflammation through the lysosome-associated membrane protein-1/CaMKII/TAK1 pathway in early brain injury after subarachnoid hemorrhage (SAH). DHLA may provide a promising treatment to alleviate early brain injury after SAH., [RefSeq, PubMed]; Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. Presents carbohydrate ligands to selectins., [UniProtKB, UniProtKB]; These findings documented that circ-LAMP1 might be an oncogene in T-cell lymphoblastic lymphoma (T-LBL), which might be useful in developing promising therapies for T-LBL., [RefSeq, PubMed]", "predicted_glycosites": 19, "predicted_n_glycosites": 18, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "P97620", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0008200 ion channel inhibitor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol", "go_biological_process": "GO:0072594 establishment of protein localization to organelle;GO:0050821 protein stabilization;GO:0090160 Golgi to lysosome transport;GO:0043323 positive regulation of natural killer cell degranulation;GO:0045954 positive regulation of natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P14562-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35577-1", "uniprot_id": [ { "id": "THBG_RAT", "url": "https://www.uniprot.org/uniprot/P35577", "type": "external" } ], "mass": 46938.0, "length": 418, "protein_name": "Thyroxine-binding globulin", "gene_name": "Serpina7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Serpina7; Tbg", "gene_names_refseq": "", "protein_names_uniprotkb": "Thyroxine-binding globulin; Serpin A7; T4-binding globulin", "protein_names_refseq": "", "tax_id": 10116, "disease": "hypothyroidism (Disease Ontology:DOID:1459); diabetic ketoacidosis (Disease Ontology:DOID:1837); hyperthyroidism (Disease Ontology:DOID:7998); diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:81806)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1903654;7988464", "class_list": "", "function": "Major thyroid hormone transport protein in serum., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0042562 hormone binding;GO:0015349 thyroid hormone transmembrane transporter activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0031667 response to nutrient levels;GO:0048545 response to steroid hormone;GO:0009791 post-embryonic development;GO:0033189 response to vitamin A;GO:0051412 response to corticosterone", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P35577-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24062-1", "uniprot_id": [ { "id": "IGF1R_RAT", "url": "https://www.uniprot.org/uniprot/P24062", "type": "external" } ], "mass": 155396.0, "length": 1370, "protein_name": "Insulin-like growth factor 1 receptor", "gene_name": "Igf1r", "organism": "Rat", "refseq_name": "insulin-like growth factor 1 receptor isoform 2 precursor", "refseq_ac": [ { "id": "NP_434694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_434694", "type": "external" } ], "gene_names_uniprotkb": "Igf1r", "gene_names_refseq": "IGF-1 receptor; IGFIRC; Igf1r; Igfr1; JTK13", "protein_names_uniprotkb": "Insulin-like growth factor 1 receptor; 2.7.10.1; IGF-I receptor; Insulin-like growth factor I receptor", "protein_names_refseq": "IGF-I receptor; insulin-like growth factor 1 receptor isoform 2 precursor; insulin-like growth factor I receptor; type-I IGF receptor", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); cardiomyopathy (Disease Ontology:DOID:0050700); alcohol dependence (Disease Ontology:DOID:0050741); Zollinger-Ellison syndrome (Disease Ontology:DOID:0050782); stroke (Disease Ontology:DOID:0051061); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); gastroschisis (Disease Ontology:DOID:11044); prostatic hypertrophy (Disease Ontology:DOID:11132); cryptorchidism (Disease Ontology:DOID:11383); osteoporosis (Disease Ontology:DOID:11476); portal vein thrombosis (Disease Ontology:DOID:11695); gestational diabetes (Disease Ontology:DOID:11714); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Lewy body dementia (Disease Ontology:DOID:12217); Graves' disease (Disease Ontology:DOID:12361); dementia (Disease Ontology:DOID:1307); alcoholic neuropathy (Disease Ontology:DOID:14183); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); nephroblastoma (Disease Ontology:DOID:2154); prostate adenocarcinoma (Disease Ontology:DOID:2526); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); toxic encephalopathy (Disease Ontology:DOID:3602); glucose metabolism disease (Disease Ontology:DOID:4194); coronary stenosis (Disease Ontology:DOID:4248); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); liver cirrhosis (Disease Ontology:DOID:5082); sleep disorder (Disease Ontology:DOID:535); gastrinoma (Disease Ontology:DOID:5577); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); neuroblastoma (Disease Ontology:DOID:769); hyperthyroidism (Disease Ontology:DOID:7998); osteoarthritis (Disease Ontology:DOID:8398); ulcerative colitis (Disease Ontology:DOID:8577); vascular dementia (Disease Ontology:DOID:8725); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); vesicoureteral reflux (Disease Ontology:DOID:9620); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25718); (R-RNO-2404192); (R-RNO-2428928); (R-RNO-2428933); (R-RNO-9009391)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "1530648;16803852;2477843;34623606;34968461;35129018;37018819;38632221;38843836;7758167", "class_list": "", "function": "Exosomes Derived from lncRNA TCTN2-Modified Mesenchymal Stem Cells Improve Spinal Cord Injury by miR-329-3p/IGF1R Axis., [RefSeq, PubMed]; IGF-1R/YAP signaling pathway is involved in collagen V-induced insulin biosynthesis and secretion in rat islet INS-1 cells., [RefSeq, PubMed]; Long non-coding RNA MALAT1 modulates myocardial ischemia-reperfusion injury through the PI3K/Akt/eNOS pathway by sponging miRNA-133a-3p to target IGF1R expression., [RefSeq, PubMed]; Mechanism of myocardial fibrosis regulation by IGF-1R in atrial fibrillation through the PI3K/Akt/FoxO3a pathway., [RefSeq, PubMed]; Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R (By similarity). When present in a hybrid receptor with INSR, binds IGF1 (By similarity)., [UniProtKB, PubMed]; The Effect of Different Exercise Modalities on Sertoli-germ Cells Metabolic Interactions in High-fat Diet-induced Obesity Rat Models: Implication on Glucose and Lactate Transport, Igf1, and Igf1R-dependent Pathways., [RefSeq, PubMed]", "predicted_glycosites": 16, "predicted_n_glycosites": 16, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 54, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0005009 insulin receptor activity;GO:0004713 protein tyrosine kinase activity;GO:0005158 insulin receptor binding;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0043279 response to alkaloid;GO:1903944 negative regulation of hepatocyte apoptotic process;GO:0048680 positive regulation of axon regeneration;GO:1904385 cellular response to angiotensin;GO:0051446 positive regulation of meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P24062-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JPK3-1", "uniprot_id": [ { "id": "ZFP57_RAT", "url": "https://www.uniprot.org/uniprot/A0JPK3", "type": "external" } ], "mass": 46588.0, "length": 406, "protein_name": "Zinc finger protein 57", "gene_name": "Mog; Zfp57", "organism": "Rat", "refseq_name": "zinc finger protein 57", "refseq_ac": [ { "id": "NP_998730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998730", "type": "external" } ], "gene_names_uniprotkb": "Mog; Zfp57; Zfp57", "gene_names_refseq": "Zfp57", "protein_names_uniprotkb": "Zinc finger protein 57; Zfp-57", "protein_names_refseq": "zfp-57; zinc finger protein 57", "tax_id": 10116, "disease": "transient neonatal diabetes mellitus 1 (Disease Ontology:DOID:0061173)", "pathway": " (rno:24558); (rno:361783)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15060004;15070898;24090084", "class_list": "", "function": "Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs). Acts together with ZNF445. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6MFY0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000792 heterochromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0071514 genomic imprinting;GO:0044726 epigenetic programing of female pronucleus;GO:0044027 negative regulation of gene expression via chromosomal CpG island methylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0JPK3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JPN4-1", "uniprot_id": [ { "id": "ZC12A_RAT", "url": "https://www.uniprot.org/uniprot/A0JPN4", "type": "external" } ], "mass": 65927.0, "length": 596, "protein_name": "Endoribonuclease ZC3H12A", "gene_name": "Zc3h12a", "organism": "Rat", "refseq_name": "endoribonuclease ZC3H12A", "refseq_ac": [ { "id": "NP_001071139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071139", "type": "external" } ], "gene_names_uniprotkb": "Zc3h12a", "gene_names_refseq": "MCPIP-1; RGD1306776; Reg1; Zc3h12a", "protein_names_uniprotkb": "Endoribonuclease ZC3H12A; 3.1.-.-; MCP-induced protein 1; MCPIP-1; Monocyte chemotactic protein-induced protein 1; Reg1; Regnase-1; Zinc finger CCCH domain-containing protein 12A", "protein_names_refseq": "MCP-induced protein 1; Zinc finger CCCH domain-containing protein 12A; bifunctional endoribonuclease and deubiquitinase ZC3H12A; endoribonuclease ZC3H12A; monocyte chemotactic protein-induced protein 1; regnase-1; ribonuclease ZC3H12A", "tax_id": 10116, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); hypothyroidism (Disease Ontology:DOID:1459); hepatitis B (Disease Ontology:DOID:2043)", "pathway": " (rno:313587)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "30631045;31323531", "class_list": "", "function": "Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay. Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation. Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity). Together with RC3H1, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Self regulates by destabilizing its own mRNA. Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (By similarity). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (By similarity). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (By similarity). Also plays a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (By similarity). Affects the overall ubiquitination of cellular proteins. Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity). Also induces deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (By similarity). Prevents stress granules (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock, and energy deprivation. Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state. May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (By similarity). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (By similarity). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial pro-inflammatory cytokine production (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Since MCPIP1 expression undergoes fluctuations in islets during type 1 diabetes development in the IDDM rat and regulates the beta-cell fate upon exposure to proinflammatory cytokines, manipulations of its expression and activity might open new perspectives for type 1 diabetes treatment. Publication Status: Online-Only, [RefSeq, PubMed]; With the help of a cecal ligation puncture-induced model of acute lung injury (ALI) in rats, we demonstrated that MCPIP1 overexpression induced by MG132 can alleviate sepsis-induced pathologic changes, increase in water content and protein leakage in the lungs, and induction of systemic inflammatory mediators, and thereby improve the 7-day mortality rate in sepsis-induced ALI., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005791 rough endoplasmic reticulum;GO:0005856 cytoskeleton", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:1990869 cellular response to chemokine;GO:2000320 negative regulation of T-helper 17 cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0JPN4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A5Q6-1", "uniprot_id": [ { "id": "SMK_RAT", "url": "https://www.uniprot.org/uniprot/A1A5Q6", "type": "external" } ], "mass": 73847.0, "length": 654, "protein_name": "Sperm motility kinase", "gene_name": "Smok", "organism": "Rat", "refseq_name": "sperm motility kinase", "refseq_ac": [ { "id": "NP_001094414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094414", "type": "external" } ], "gene_names_uniprotkb": "Smok", "gene_names_refseq": "RGD1562638; RGD1564276; Smok", "protein_names_uniprotkb": "Sperm motility kinase; 2.7.11.1", "protein_names_refseq": "sperm motility kinase", "tax_id": 10116, "disease": "", "pathway": " (rno:290818)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in sperm motility, especially in the regulation of flagellar function., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0042149 cellular response to glucose starvation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A5Q6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A5R9-1", "uniprot_id": [ { "id": "STPG2_RAT", "url": "https://www.uniprot.org/uniprot/A1A5R9", "type": "external" } ], "mass": 63424.0, "length": 563, "protein_name": "Sperm-tail PG-rich repeat-containing protein 2", "gene_name": "Stpg2", "organism": "Rat", "refseq_name": "sperm-tail PG-rich repeat-containing protein 2", "refseq_ac": [ { "id": "NP_001094463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094463", "type": "external" } ], "gene_names_uniprotkb": "Stpg2", "gene_names_refseq": "Stpg2", "protein_names_uniprotkb": "Sperm-tail PG-rich repeat-containing protein 2", "protein_names_refseq": "sperm-tail PG-rich repeat-containing protein 2; uncharacterized protein C4orf37 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:499719)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A5R9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27791-1", "uniprot_id": [ { "id": "KAPCA_RAT", "url": "https://www.uniprot.org/uniprot/P27791", "type": "external" } ], "mass": 40620.0, "length": 351, "protein_name": "cAMP-dependent protein kinase catalytic subunit alpha", "gene_name": "Prkaca", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prkaca", "gene_names_refseq": "", "protein_names_uniprotkb": "cAMP-dependent protein kinase catalytic subunit alpha; 2.7.11.11; PKA C-alpha", "protein_names_refseq": "", "tax_id": 10116, "disease": "adrenal cortical adenoma (Disease Ontology:DOID:0050891); primary pigmented nodular adrenocortical disease 4 (Disease Ontology:DOID:0070549); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); fibrolamellar carcinoma (Disease Ontology:DOID:5015); congestive heart failure (Disease Ontology:DOID:6000); amphetamine abuse (Disease Ontology:DOID:670)", "pathway": " (rno:25636); (R-RNO-163615); (R-RNO-164378); (R-RNO-180024); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-381676); (R-RNO-392517); (R-RNO-422356); (R-RNO-432040); (R-RNO-4420097); (R-RNO-442720); (R-RNO-512988); (R-RNO-5578775); (R-RNO-5610785); (R-RNO-5610787); (R-RNO-5620912); (R-RNO-5621575); (R-RNO-5687128); (R-RNO-8853659); (R-RNO-8854518); (R-RNO-8963896); (R-RNO-9634597); (R-RNO-983231); (R-RNO-9837999); (R-RNO-9856530)", "pathway_count": 29, "publication_count": 7, "publication_id_list": "14514679;1711374;20844122;22673903;23419316;38843836;9521123", "class_list": "", "function": "Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, histone H1.4 (H1-4), PSMC5/RPT6, PJA2, RYR2, RORA, SLC6A6, SOX9, UHRF1 and VASP. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (By similarity). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (By similarity). Acts as a key inhibitor of smoothened signaling pathway by mediating phosphorylation of GLI (GLI1, GLI2 and GLI3) transcription factors in absence of hedgehog (DHH, IHH or SHH) morphogens: GLI phosphorylation promotes their processing and prevents transcriptional activation of smoothened target genes (By similarity). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (By similarity). Also inhibits the smoothened signaling pathway in embryonic development by catalyzing phosphorylation of OFD1 in ciliogenesis (By similarity). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (PubMed:20844122). Phosphorylates APOBEC3G and AICDA. Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock. Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR. Phosphorylates AKAP19 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6UA68", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0043457 regulation of cellular respiration;GO:0070417 cellular response to cold;GO:1904539 negative regulation of glycolytic process through fructose-6-phosphate;GO:0006397 mRNA processing;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P27791-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4V8B4-1", "uniprot_id": [ { "id": "SAV1_RAT", "url": "https://www.uniprot.org/uniprot/A4V8B4", "type": "external" } ], "mass": 45046.0, "length": 387, "protein_name": "Protein salvador homolog 1", "gene_name": "Sav1", "organism": "Rat", "refseq_name": "protein salvador homolog 1", "refseq_ac": [ { "id": "NP_001091050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091050", "type": "external" } ], "gene_names_uniprotkb": "Sav1; Ww45", "gene_names_refseq": "Sav1", "protein_names_uniprotkb": "Protein salvador homolog 1; 45 kDa WW domain protein; rWW45", "protein_names_refseq": "45 kDa WW domain protein; Salvador homolog 1 protein; protein salvador homolog 1; rWW45", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162); kidney cancer (Disease Ontology:DOID:263); colonic disease (Disease Ontology:DOID:5353); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:299116); (R-RNO-2028269)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0140537 transcription regulator activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0045600 positive regulation of fat cell differentiation;GO:0006915 apoptotic process;GO:0035329 hippo signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4V8B4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H909-1", "uniprot_id": [ { "id": "TBPL2_RAT", "url": "https://www.uniprot.org/uniprot/A6H909", "type": "external" } ], "mass": 38355.0, "length": 344, "protein_name": "TATA box-binding protein-like 2", "gene_name": "Tbpl2", "organism": "Rat", "refseq_name": "TATA box-binding protein-like 2", "refseq_ac": [ { "id": "NP_001092831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092831", "type": "external" } ], "gene_names_uniprotkb": "Tbpl2; Tbp2; Trf3", "gene_names_refseq": "Tbpl2", "protein_names_uniprotkb": "TATA box-binding protein-like 2; TATA box-binding protein-related factor 3; TBP-like 2; TBP-related factor 3", "protein_names_refseq": "TATA box-binding protein-like 2; TATA box-binding protein-like protein 2; TATA box-binding protein-related factor 3; TBP-like 2; TBP-like protein 2; TBP-related factor 3", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:680050)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17570761", "class_list": "", "function": "Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0001674 female germ cell nucleus", "go_biological_process": "GO:0006352 DNA-templated transcription initiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6H909-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BMY1-1", "uniprot_id": [ { "id": "LAAT1_RAT", "url": "https://www.uniprot.org/uniprot/B0BMY1", "type": "external" } ], "mass": 32232.0, "length": 293, "protein_name": "Lysosomal amino acid transporter 1 homolog", "gene_name": "Slc66a1", "organism": "Rat", "refseq_name": "lysosomal amino acid transporter 1 homolog isoform 2", "refseq_ac": [ { "id": "NP_001386162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386162", "type": "external" } ], "gene_names_uniprotkb": "Slc66a1; Pqlc2", "gene_names_refseq": "Pqlc2; Slc66a1", "protein_names_uniprotkb": "Lysosomal amino acid transporter 1 homolog; PQ-loop repeat-containing protein 2; Solute carrier family 66 member 1", "protein_names_refseq": "PQ loop repeat containing 2; PQ-loop repeat-containing protein 2; lysosomal amino acid transporter 1 homolog isoform 2; lysosomal amino acid transporter 1 homolog", "tax_id": 10116, "disease": "lysosomal storage disease (Disease Ontology:DOID:3211)", "pathway": " (rno:362642); (R-RNO-5223345)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23169667", "class_list": "", "function": "Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F7FC79", "ec_number_list": [], "go_molecular_function": "GO:0015174 basic amino acid transmembrane transporter activity;GO:0015189 L-lysine transmembrane transporter activity;GO:0005290 L-histidine transmembrane transporter activity;GO:0061459 L-arginine transmembrane transporter activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031090 organelle membrane;GO:0016020 membrane", "go_biological_process": "GO:0015819 lysine transport;GO:0080144 intracellular amino acid homeostasis;GO:0089709 L-histidine transmembrane transport;GO:1903401 L-lysine transmembrane transport;GO:1903826 L-arginine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0BMY1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BN70-1", "uniprot_id": [ { "id": "SMIM7_RAT", "url": "https://www.uniprot.org/uniprot/B0BN70", "type": "external" } ], "mass": 8583.0, "length": 75, "protein_name": "Small integral membrane protein 7", "gene_name": "Smim7", "organism": "Rat", "refseq_name": "small integral membrane protein 7 precursor", "refseq_ac": [ { "id": "NP_001128724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128724", "type": "external" } ], "gene_names_uniprotkb": "Smim7", "gene_names_refseq": "Smim7", "protein_names_uniprotkb": "Small integral membrane protein 7", "protein_names_refseq": "UPF0608 protein C19orf42 homolog; small integral membrane protein 7 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:688495)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BN70-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BN85-1", "uniprot_id": [ { "id": "SGT1_RAT", "url": "https://www.uniprot.org/uniprot/B0BN85", "type": "external" } ], "mass": 38091.0, "length": 336, "protein_name": "Protein SGT1 homolog", "gene_name": "Sugt1", "organism": "Rat", "refseq_name": "protein SGT1 homolog", "refseq_ac": [ { "id": "NP_001013069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013069", "type": "external" } ], "gene_names_uniprotkb": "Sugt1", "gene_names_refseq": "Aa1114; Sugt1", "protein_names_uniprotkb": "Protein SGT1 homolog; Suppressor of G2 allele of SKP1 homolog", "protein_names_refseq": "SGT1 homolog, MIS12 kinetochore complex assembly cochaperone; Suppressor of G2 allele of SKP1 homolog; protein SGT1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:290408); (R-RNO-844456)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in ubiquitination and subsequent proteasomal degradation of target proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0106222 lncRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0000776 kinetochore;GO:0032991 protein-containing complex", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0031647 regulation of protein stability;GO:0007051 spindle organization;GO:0014841 skeletal muscle satellite cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BN85-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BNA1-1", "uniprot_id": [ { "id": "SH3Y1_RAT", "url": "https://www.uniprot.org/uniprot/B0BNA1", "type": "external" } ], "mass": 37039.0, "length": 340, "protein_name": "SH3 domain-containing YSC84-like protein 1", "gene_name": "Sh3yl1", "organism": "Rat", "refseq_name": "SH3 domain-containing YSC84-like protein 1", "refseq_ac": [ { "id": "NP_001102175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102175", "type": "external" } ], "gene_names_uniprotkb": "Sh3yl1", "gene_names_refseq": "Sh3yl1", "protein_names_uniprotkb": "SH3 domain-containing YSC84-like protein 1", "protein_names_refseq": "SH3 domain containing, Ysc84-like 1; SH3 domain-containing YSC84-like protein 1; Sh3 domain YSC-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:362724)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0032587 ruffle membrane", "go_biological_process": "GO:1900027 regulation of ruffle assembly;GO:0006661 phosphatidylinositol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BNA1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BNK7-1", "uniprot_id": [ { "id": "LRFN3_RAT", "url": "https://www.uniprot.org/uniprot/B0BNK7", "type": "external" } ], "mass": 66068.0, "length": 626, "protein_name": "Leucine-rich repeat and fibronectin type-III domain-containing protein 3", "gene_name": "Lrfn3", "organism": "Rat", "refseq_name": "leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor", "refseq_ac": [ { "id": "NP_001100972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100972", "type": "external" } ], "gene_names_uniprotkb": "Lrfn3; Salm4", "gene_names_refseq": "Lrfn3; Salm4", "protein_names_uniprotkb": "Leucine-rich repeat and fibronectin type-III domain-containing protein 3; Synaptic adhesion-like molecule 4", "protein_names_refseq": "leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor; leucine-rich repeat and fibronectin type-III domain-containing protein 3; synaptic adhesion-like molecule 4", "tax_id": 10116, "disease": "", "pathway": " (rno:308495); (R-RNO-8849932)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18227064;20600927;38843836", "class_list": "", "function": "Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity)., [UniProtKB]; Data reveal a flotillin-1 signaling pathway for hippocampal neurite branching that is regulated by synaptic adhesion-like molecule 4., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0099560 synaptic membrane adhesion;GO:0099179 regulation of synaptic membrane adhesion;GO:1905606 regulation of presynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B0BNK7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0K036-1", "uniprot_id": [ { "id": "SDHF1_RAT", "url": "https://www.uniprot.org/uniprot/B0K036", "type": "external" } ], "mass": 13312.0, "length": 118, "protein_name": "Succinate dehydrogenase assembly factor 1, mitochondrial", "gene_name": "Sdhaf1", "organism": "Rat", "refseq_name": "succinate dehydrogenase assembly factor 1, mitochondrial", "refseq_ac": [ { "id": "NP_001171158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171158", "type": "external" } ], "gene_names_uniprotkb": "Sdhaf1; Lyrm8", "gene_names_refseq": "Lyrm8; RGD1562079; Sdhaf1", "protein_names_uniprotkb": "Succinate dehydrogenase assembly factor 1, mitochondrial; LYR motif-containing protein 8; SDH assembly factor 1; SDHAF1", "protein_names_refseq": "LYR motif-containing protein 8; SDH assembly factor 1; succinate dehydrogenase assembly factor 1, mitochondrial", "tax_id": 10116, "disease": "mitochondrial complex II deficiency (Disease Ontology:DOID:0060537)", "pathway": " (rno:499125); (R-RNO-9854311)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit Sdhb of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3. Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0034553 mitochondrial respiratory chain complex II assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0K036-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0LT89-1", "uniprot_id": [ { "id": "STK24_RAT", "url": "https://www.uniprot.org/uniprot/B0LT89", "type": "external" } ], "mass": 47990.0, "length": 431, "protein_name": "Serine/threonine-protein kinase 24", "gene_name": "Stk24", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase 24", "refseq_ac": [ { "id": "NP_001120966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120966", "type": "external" } ], "gene_names_uniprotkb": "Stk24; LOC134486345; Mst3; Stk3", "gene_names_refseq": "MST-3; Mst3b; RGD1561742; Stk24", "protein_names_uniprotkb": "Serine/threonine-protein kinase 24; 2.7.11.1; MST-3; MST3/C; MST3/N; MST3b; Mammalian STE20-like protein kinase 3 C-terminal; Mammalian STE20-like protein kinase 3 N-terminal; Mammalian STE20-like protein kinase 3; STE20-like kinase MST3", "protein_names_refseq": "STE20-like kinase MST3; mammalian STE20-like protein kinase 3; serine/threonine kinase 24 (STE20 homolog, yeast); serine/threonine-protein kinase 24", "tax_id": 10116, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669)", "pathway": " (rno:361092); (R-RNO-111465); (R-RNO-75153)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "17114295;19855390;24990316;30328087", "class_list": "", "function": "Mst3b was identified as a powerful regulator for promoting spinal cord injury recovery., [RefSeq, PubMed]; Mst3b, a neuron-specific homolog of the yeast kinase Ste20, is critical for axon outgrowth. Mst3b is activated in response to trophic factors, and suppressing its expression, [RefSeq, PubMed]; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12 (By similarity). May act as a key regulator of axon regeneration in the optic nerve and radial nerve (PubMed:19855390). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (By similarity)., [UniProtKB, PubMed, UniProtKB]; This is the first study reporting that MST3, a Ste20-like kinase, exerts a conserved regulatory role in sodium homeostasis after high-salt diet and in the development of hypertension., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LML1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0048679 regulation of axon regeneration;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B0LT89-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1WBS3-1", "uniprot_id": [ { "id": "ZBT42_RAT", "url": "https://www.uniprot.org/uniprot/B1WBS3", "type": "external" } ], "mass": 46628.0, "length": 420, "protein_name": "Zinc finger and BTB domain-containing protein 42", "gene_name": "Zbtb42", "organism": "Rat", "refseq_name": "zinc finger and BTB domain-containing protein 42", "refseq_ac": [ { "id": "NP_001119774", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119774", "type": "external" } ], "gene_names_uniprotkb": "Zbtb42", "gene_names_refseq": "Zbtb42", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 42", "protein_names_refseq": "zinc finger and BTB domain-containing protein 42", "tax_id": 10116, "disease": "lethal congenital contracture syndrome (Disease Ontology:DOID:0060558)", "pathway": " (rno:691556)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1WBS3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GUY2-1", "uniprot_id": [ { "id": "TFR2_RAT", "url": "https://www.uniprot.org/uniprot/B2GUY2", "type": "external" } ], "mass": 88328.0, "length": 798, "protein_name": "Transferrin receptor protein 2", "gene_name": "Tfr2", "organism": "Rat", "refseq_name": "transferrin receptor protein 2", "refseq_ac": [ { "id": "NP_001099386", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099386", "type": "external" } ], "gene_names_uniprotkb": "Tfr2; Trfr2", "gene_names_refseq": "Tfr2; Trfr2", "protein_names_uniprotkb": "Transferrin receptor protein 2; TfR2", "protein_names_refseq": "transferrin receptor protein 2", "tax_id": 10116, "disease": "hemochromatosis type 3 (Disease Ontology:DOID:0111030); hemochromatosis (Disease Ontology:DOID:2352); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:288562); (R-RNO-917977)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21454685;23582421;31707638;32521439", "class_list": "", "function": "A mutation with the Tfr2 gene causes hemochromatosis in the rat., [RefSeq, PubMed]; Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Repeated Restraint Stress Enhances Hepatic TFR2 Expression and Induces Hepatic Iron Accumulation in Rats., [RefSeq, PubMed]; Role of Slc19a1 and Tfr2 in liver transport of iron and folate: A rat model of folate/iron deficiency followed by supplementation., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004998 transferrin receptor activity;GO:0039706 co-receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0031410 cytoplasmic vesicle;GO:1990712 HFE-transferrin receptor complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006879 intracellular iron ion homeostasis;GO:0006953 acute-phase response;GO:0006898 receptor-mediated endocytosis;GO:0071281 cellular response to iron ion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B2GUY2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GV91-1", "uniprot_id": [ { "id": "LYRM2_RAT", "url": "https://www.uniprot.org/uniprot/B2GV91", "type": "external" } ], "mass": 10410.0, "length": 88, "protein_name": "LYR motif-containing protein 2", "gene_name": "Lyrm2", "organism": "Rat", "refseq_name": "LYR motif-containing protein 2", "refseq_ac": [ { "id": "NP_001119568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119568", "type": "external" } ], "gene_names_uniprotkb": "Lyrm2", "gene_names_refseq": "Lyrm2", "protein_names_uniprotkb": "LYR motif-containing protein 2", "protein_names_refseq": "LYR motif-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:690354); (R-RNO-6799198)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2GV91-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RYD6-1", "uniprot_id": [ { "id": "IT70B_RAT", "url": "https://www.uniprot.org/uniprot/B2RYD6", "type": "external" } ], "mass": 76077.0, "length": 664, "protein_name": "Intraflagellar transport protein 70B", "gene_name": "Ift70b", "organism": "Rat", "refseq_name": "intraflagellar transport protein 70B", "refseq_ac": [ { "id": "NP_001121079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121079", "type": "external" } ], "gene_names_uniprotkb": "Ift70b; Ttc30b", "gene_names_refseq": "Ift70b; Ttc30b", "protein_names_uniprotkb": "Intraflagellar transport protein 70B; TPR repeat protein 30B; Tetratricopeptide repeat protein 30B", "protein_names_refseq": "TPR repeat protein 30B; intraflagellar transport protein 70B; tetratricopeptide repeat domain 30B; tetratricopeptide repeat protein 30B", "tax_id": 10116, "disease": "", "pathway": " (rno:499814); (R-RNO-5620924)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0120170 intraciliary transport particle B binding", "go_cellular_component": "GO:0005879 axonemal microtubule;GO:0030991 intraciliary transport particle A;GO:0030992 intraciliary transport particle B", "go_biological_process": "GO:0042073 intraciliary transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RYD6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RYW8-1", "uniprot_id": [ { "id": "MIC10_RAT", "url": "https://www.uniprot.org/uniprot/B2RYW8", "type": "external" } ], "mass": 8550.0, "length": 76, "protein_name": "MICOS complex subunit Mic10", "gene_name": "Micos10", "organism": "Rat", "refseq_name": "MICOS complex subunit Mic10", "refseq_ac": [ { "id": "NP_001167027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001167027", "type": "external" } ], "gene_names_uniprotkb": "Micos10; Mic10; Minos1", "gene_names_refseq": "Micos10; Minos1; RGD1560187", "protein_names_uniprotkb": "MICOS complex subunit Mic10; Mitochondrial inner membrane organizing system protein 1", "protein_names_refseq": "MICOS complex subunit Mic10; mitochondrial inner membrane organizing system 1; mitochondrial inner membrane organizing system protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:362641)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0061617 MICOS complex", "go_biological_process": "GO:0042407 cristae formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2RYW8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RZ55-1", "uniprot_id": [ { "id": "SIR7_RAT", "url": "https://www.uniprot.org/uniprot/B2RZ55", "type": "external" } ], "mass": 45113.0, "length": 402, "protein_name": "NAD-dependent protein deacetylase sirtuin-7", "gene_name": "Sirt7", "organism": "Rat", "refseq_name": "NAD-dependent protein deacetylase sirtuin-7", "refseq_ac": [ { "id": "NP_001100543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100543", "type": "external" } ], "gene_names_uniprotkb": "Sirt7", "gene_names_refseq": "Sirt7", "protein_names_uniprotkb": "NAD-dependent protein deacetylase sirtuin-7; 2.3.1.-; 2.3.1.286; NAD-dependent protein deacylase sirtuin-7; Regulatory protein SIR2 homolog 7; SIR2-like protein 7", "protein_names_refseq": "NAD-dependent deacetylase sirtuin-7; NAD-dependent protein deacetylase sirtuin-7; NAD-dependent protein deacylase sirtuin-7; SIR2-like protein 7; regulatory protein SIR2 homolog 7", "tax_id": 10116, "disease": "", "pathway": " (rno:303745)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "31858380;33558457;34477918;35941302", "class_list": "", "function": "Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; NAD-dependent protein-lysine deacylase that can act both as a deacetylase or deacylase (desuccinylase, depropionylase, deglutarylase and dedecanoylase), depending on the context. Specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays strong preference for a specific histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors; SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. Also able to mediate deacetylation of histone H3 at 'Lys-36' (H3K36Ac) in the context of nucleosomes. Also mediates deacetylation of non-histone proteins, such as ATM, CDK9, DDX21, DDB1, FBL, FKBP5/FKBP51, GABPB1, RAN, RRP9/U3-55K and POLR1E/PAF53. Enriched in nucleolus where it stimulates transcription activity of the RNA polymerase I complex. Acts by mediating the deacetylation of the RNA polymerase I subunit POLR1E/PAF53, thereby promoting the association of RNA polymerase I with the rDNA promoter region and coding region. In response to metabolic stress, SIRT7 is released from nucleoli leading to hyperacetylation of POLR1E/PAF53 and decreased RNA polymerase I transcription. Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis. Promotes pre-ribosomal RNA (pre-rRNA) cleavage at the 5'-terminal processing site by mediating deacetylation of RRP9/U3-55K, a core subunit of the U3 snoRNP complex. Mediates 'Lys-37' deacetylation of Ran, thereby regulating the nuclear export of NF-kappa-B subunit RELA/p65. Acts as a regulator of DNA damage repair by mediating deacetylation of ATM during the late stages of DNA damage response, promoting ATM dephosphorylation and deactivation. Suppresses the activity of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes by mediating deacetylation of DDB1, which prevents the interaction between DDB1 and CUL4 (CUL4A or CUL4B). Activates RNA polymerase II transcription by mediating deacetylation of CDK9, thereby promoting 'Ser-2' phosphorylation of the C-terminal domain (CTD) of RNA polymerase II. Deacetylates FBL, promoting histone-glutamine methyltransferase activity of FBL (By similarity). Acts as a regulator of mitochondrial function by catalyzing deacetylation of GABPB1 (By similarity). Regulates Akt/AKT1 activity by mediating deacetylation of FKBP5/FKBP51. Required to prevent R-loop-associated DNA damage and transcription-associated genomic instability by mediating deacetylation and subsequent activation of DDX21, thereby overcoming R-loop-mediated stalling of RNA polymerases. In addition to protein deacetylase activity, also acts as a protein-lysine deacylase (By similarity). Acts as a protein depropionylase by mediating depropionylation of Osterix (SP7), thereby regulating bone formation by osteoblasts (By similarity). Acts as a histone deglutarylase by mediating deglutarylation of histone H4 on 'Lys-91' (H4K91glu); a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes. Acts as a histone desuccinylase: in response to DNA damage, recruited to DNA double-strand breaks (DSBs) and catalyzes desuccinylation of histone H3 on 'Lys-122' (H3K122succ), thereby promoting chromatin condensation and DSB repair (By similarity). Also promotes DSB repair by promoting H3K18Ac deacetylation, regulating non-homologous end joining (NHEJ). Along with its role in DNA repair, required for chromosome synapsis during prophase I of female meiosis by catalyzing H3K18Ac deacetylation (By similarity). Involved in transcriptional repression of LINE-1 retrotransposon via H3K18Ac deacetylation, and promotes their association with the nuclear lamina. Required to stabilize ribosomal DNA (rDNA) heterochromatin and prevent cellular senescence induced by rDNA instability (By similarity). Acts as a negative regulator of SIRT1 by preventing autodeacetylation of SIRT1, restricting SIRT1 deacetylase activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Resveratrol Promotes Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells Through miR-193a/SIRT7 Axis., [RefSeq, PubMed]; SIRT7 silencing by miR-152-3p confers cell apoptosis and renal functional impairment induced by renal ischaemia/reperfusion injury., [RefSeq, PubMed]; The injection of BMSC-Exo-125b alleviated the pathological damages and down-regulated SIRT7 in myocardium tissues of I/R rats. BMSC-derived exosomes carrying miR-125b protected against myocardial I/R by targeting SIRT7., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LQY4", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" } ], "go_molecular_function": "GO:0036055 protein-succinyllysine desuccinylase activity;GO:0061697 protein-glutaryllysine deglutarylase activity;GO:0097372 histone H3K18 deacetylase activity, NAD-dependent;GO:0003682 chromatin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005731 nucleolus organizer region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:2000234 positive regulation of rRNA processing;GO:1901836 regulation of transcription of nucleolar large rRNA by RNA polymerase I;GO:0061698 protein deglutarylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B2RZ55-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RZC9-1", "uniprot_id": [ { "id": "KTAP2_RAT", "url": "https://www.uniprot.org/uniprot/B2RZC9", "type": "external" } ], "mass": 14662.0, "length": 136, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2", "gene_name": "Krtcap2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Krtcap2", "gene_names_refseq": "", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2; KCP-2; Keratinocyte-associated protein 2; Oligosaccharyl transferase subunit KCP2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:295243)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Subunit of STT3A-containing oligosaccharyl transferase (OST-A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex;GO:0160226 oligosaccharyltransferase complex A;GO:0016020 membrane", "go_biological_process": "GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RZC9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RZD7-1", "uniprot_id": [ { "id": "LYRM9_RAT", "url": "https://www.uniprot.org/uniprot/B2RZD7", "type": "external" } ], "mass": 9379.0, "length": 78, "protein_name": "LYR motif-containing protein 9", "gene_name": "Lyrm9", "organism": "Rat", "refseq_name": "LYR motif-containing protein 9", "refseq_ac": [ { "id": "NP_001166942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166942", "type": "external" } ], "gene_names_uniprotkb": "Lyrm9", "gene_names_refseq": "Lyrm9; RGD1562012", "protein_names_uniprotkb": "LYR motif-containing protein 9", "protein_names_refseq": "LYR motif-containing protein 9; UPF0631 protein C17orf108 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:497962)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RZD7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3EY83-1", "uniprot_id": [ { "id": "LCN12_RAT", "url": "https://www.uniprot.org/uniprot/B3EY83", "type": "external" } ], "mass": 22222.0, "length": 193, "protein_name": "Epididymal-specific lipocalin-12", "gene_name": "C8g; Lcn12", "organism": "Rat", "refseq_name": "epididymal-specific lipocalin-12 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001382003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382003", "type": "external" } ], "gene_names_uniprotkb": "C8g; Lcn12; C8g; Lcn12", "gene_names_refseq": "Lcn12", "protein_names_uniprotkb": "Epididymal-specific lipocalin-12", "protein_names_refseq": "epididymal-specific lipocalin-12 isoform 1 precursor; epididymal-specific lipocalin-12", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-804914)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20692383;21538546", "class_list": "", "function": "Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C8G, together with C8A and C8B, inserts into the target membrane, but does not form pores by itself. During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RLcn12 could be involved in retinoic acid transport in the epididymis, [RefSeq, PubMed]; Solution structure of the protein lipocalin 12 from rat epididymis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D3ZI71", "ec_number_list": [], "go_molecular_function": "GO:0001972 retinoic acid binding;GO:0036094 small molecule binding;GO:0044877 protein-containing complex binding;GO:0001848 complement binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region;GO:0005579 membrane attack complex;GO:0005886 plasma membrane;GO:0044218 other organism cell membrane", "go_biological_process": "GO:0006956 complement activation;GO:0055085 transmembrane transport;GO:0031640 killing of cells of another organism;GO:0160257 complement activation, GZMK pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B3EY83-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B4F769-1", "uniprot_id": [ { "id": "SMAL1_RAT", "url": "https://www.uniprot.org/uniprot/B4F769", "type": "external" } ], "mass": 101212.0, "length": 910, "protein_name": "SNF2 related chromatin remodeling annealing helicase 1", "gene_name": "Smarcal1", "organism": "Rat", "refseq_name": "SNF2 related chromatin remodeling annealing helicase 1 isoform 2", "refseq_ac": [ { "id": "NP_001101692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101692", "type": "external" } ], "gene_names_uniprotkb": "Smarcal1; Harp", "gene_names_refseq": "Smarcal1", "protein_names_uniprotkb": "SNF2 related chromatin remodeling annealing helicase 1; 3.6.4.-; 5.6.2.-; HepA-related protein; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; Sucrose nonfermenting protein 2-like 1", "protein_names_refseq": "SNF2 related chromatin remodeling annealing helicase 1 isoform 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; Swi/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1; hepA-related protein; sucrose nonfermenting protein 2-like 1", "tax_id": 10116, "disease": "Schimke immuno-osseous dysplasia (Disease Ontology:DOID:0060490)", "pathway": " (rno:316477)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0036310 ATP-dependent DNA/DNA annealing activity;GO:0008094 ATP-dependent activity, acting on DNA;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break;GO:0005662 DNA replication factor A complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0031297 replication fork processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B4F769-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DF11-1", "uniprot_id": [ { "id": "ZFAN5_RAT", "url": "https://www.uniprot.org/uniprot/B5DF11", "type": "external" } ], "mass": 23088.0, "length": 213, "protein_name": "AN1-type zinc finger protein 5", "gene_name": "Zfand5", "organism": "Rat", "refseq_name": "AN1-type zinc finger protein 5", "refseq_ac": [ { "id": "NP_001388327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388327", "type": "external" } ], "gene_names_uniprotkb": "Zfand5; Zfp216; Znf216", "gene_names_refseq": "Zfand5; Zfp216", "protein_names_uniprotkb": "AN1-type zinc finger protein 5; Zinc finger protein 216", "protein_names_refseq": "AN1-type zinc finger protein 5; zinc finger protein 216; zinc finger, AN1-type domain 5", "tax_id": 10116, "disease": "", "pathway": " (rno:293960)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21923101", "class_list": "", "function": "Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0003016 respiratory system process;GO:0060324 face development;GO:0048705 skeletal system morphogenesis;GO:0001944 vasculature development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B5DF11-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DF94-1", "uniprot_id": [ { "id": "SRPX2_RAT", "url": "https://www.uniprot.org/uniprot/B5DF94", "type": "external" } ], "mass": 52853.0, "length": 466, "protein_name": "Sushi repeat-containing protein SRPX2", "gene_name": "Srpx2", "organism": "Rat", "refseq_name": "sushi repeat-containing protein SRPX2 precursor", "refseq_ac": [ { "id": "NP_001101713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101713", "type": "external" } ], "gene_names_uniprotkb": "Srpx2", "gene_names_refseq": "RGD1562444; Srpx2", "protein_names_uniprotkb": "Sushi repeat-containing protein SRPX2", "protein_names_refseq": "sushi repeat-containing protein SRPX2 precursor; sushi repeat-containing protein SRPX2", "tax_id": 10116, "disease": "", "pathway": " (rno:317181)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "24179158;29393594;31650880", "class_list": "", "function": "Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF (By similarity). Promotes synapse formation., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Acute Downregulation of Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 after Experimental Traumatic Brain Injury., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036458 hepatocyte growth factor binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0045202 synapse", "go_biological_process": "GO:0001525 angiogenesis;GO:0098609 cell-cell adhesion;GO:0051965 positive regulation of synapse assembly;GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis;GO:0051963 regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B5DF94-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DFA1-1", "uniprot_id": [ { "id": "TBD2A_RAT", "url": "https://www.uniprot.org/uniprot/B5DFA1", "type": "external" } ], "mass": 104975.0, "length": 924, "protein_name": "TBC1 domain family member 2A", "gene_name": "Tbc1d2", "organism": "Rat", "refseq_name": "TBC1 domain family member 2A", "refseq_ac": [ { "id": "NP_001386092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386092", "type": "external" } ], "gene_names_uniprotkb": "Tbc1d2; Tbc1d2a", "gene_names_refseq": "Tbc1d2", "protein_names_uniprotkb": "TBC1 domain family member 2A", "protein_names_refseq": "TBC1 domain family member 2A", "tax_id": 10116, "disease": "", "pathway": " (rno:313234); (R-RNO-8854214)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0045296 cadherin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B5DFA1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B6VQA5-1", "uniprot_id": [ { "id": "SPT31_RAT", "url": "https://www.uniprot.org/uniprot/B6VQA5", "type": "external" } ], "mass": 119551.0, "length": 1048, "protein_name": "Spermatogenesis-associated protein 31", "gene_name": "Spata31", "organism": "Rat", "refseq_name": "spermatogenesis-associated protein 31", "refseq_ac": [ { "id": "NP_001008360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008360", "type": "external" } ], "gene_names_uniprotkb": "Spata31; Aep1; Vad1.3", "gene_names_refseq": "Aep1; Fam75a4; Spata31a5; Spata31", "protein_names_uniprotkb": "Spermatogenesis-associated protein 31; Acrosome-expressed protein 1", "protein_names_refseq": "SPATA31 subfamily A member 5; acrosome-expressed protein 1; acrosome-specific protein VAD1.3; family with sequence similarity 75, member A4; spermatogenesis associated 31 subfamily A, member 5; spermatogenesis-associated protein 31", "tax_id": 10116, "disease": "", "pathway": " (rno:353306)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12878178;16924657;20850414", "class_list": "", "function": "May play a role in spermatogenesis., [UniProtKB, PubMed]; VAD1.3 interacts with beta-actin and syntaxin 1 in vitro., [RefSeq, PubMed]; VAD1.3 protein/AEP1 is expressed during spermatogenesis and interacts with beta-actin., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5U2N7;Q7TSL1", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0001669 acrosomal vesicle;GO:0002080 acrosomal membrane;GO:0043160 acrosomal lumen", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B6VQA5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z813-1", "uniprot_id": [ { "id": "S38AB_RAT", "url": "https://www.uniprot.org/uniprot/D3Z813", "type": "external" } ], "mass": 49567.0, "length": 453, "protein_name": "Putative sodium-coupled neutral amino acid transporter 11", "gene_name": "Slc38a11", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc38a11", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative sodium-coupled neutral amino acid transporter 11; Solute carrier family 38 member 11", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:362141)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18418736", "class_list": "", "function": "Putative sodium-dependent amino acid/proton antiporter., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0008324 monoatomic cation transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015291 secondary active transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006814 sodium ion transport;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z813-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z9Z9-1", "uniprot_id": [ { "id": "SMRCD_RAT", "url": "https://www.uniprot.org/uniprot/D3Z9Z9", "type": "external" } ], "mass": 116788.0, "length": 1024, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1", "gene_name": "Smarcad1", "organism": "Rat", "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 isoform 1", "refseq_ac": [ { "id": "NP_001101334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101334", "type": "external" } ], "gene_names_uniprotkb": "Smarcad1", "gene_names_refseq": "Smarcad1", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1; 3.6.4.-", "protein_names_refseq": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 isoform 1; SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1`; SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1", "tax_id": 10116, "disease": "asphyxiating thoracic dystrophy (Disease Ontology:DOID:0050592); BASAN syndrome (Disease Ontology:DOID:0080725); adermatoglyphia (Disease Ontology:DOID:0111357)", "pathway": " (rno:312398)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Protein that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Combines the ATP-dependent ability to exchange histones, with the chaperone-like ATP-independent activity to deposit histones and assemble nucleosomes. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0035861 site of double-strand break", "go_biological_process": "GO:0000018 regulation of DNA recombination;GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051304 chromosome separation;GO:0000729 DNA double-strand break processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3Z9Z9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZA50-1", "uniprot_id": [ { "id": "KLH15_RAT", "url": "https://www.uniprot.org/uniprot/D3ZA50", "type": "external" } ], "mass": 69745.0, "length": 604, "protein_name": "Kelch-like protein 15", "gene_name": "Klhl15", "organism": "Rat", "refseq_name": "kelch-like protein 15", "refseq_ac": [ { "id": "NP_001101491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101491", "type": "external" } ], "gene_names_uniprotkb": "Klhl15", "gene_names_refseq": "Klhl15; RGD1563101", "protein_names_uniprotkb": "Kelch-like protein 15", "protein_names_refseq": "kelch-like 15; kelch-like protein 15", "tax_id": 10116, "disease": "non-syndromic X-linked intellectual disability 103 (Disease Ontology:DOID:0112020)", "pathway": " (rno:314111)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23135275", "class_list": "", "function": "Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits and regulating PP2A holoenzyme composition. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZA50-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZD05-1", "uniprot_id": [ { "id": "KANK2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZD05", "type": "external" } ], "mass": 90884.0, "length": 847, "protein_name": "KN motif and ankyrin repeat domain-containing protein 2", "gene_name": "Kank2", "organism": "Rat", "refseq_name": "KN motif and ankyrin repeat domain-containing protein 2 isoform X1", "refseq_ac": [ { "id": "XP_006242651", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006242651", "type": "external" } ], "gene_names_uniprotkb": "Kank2", "gene_names_refseq": "Kank2; RGD1563532", "protein_names_uniprotkb": "KN motif and ankyrin repeat domain-containing protein 2", "protein_names_refseq": "KN motif and ankyrin repeat domain-containing protein 2 isoform X1", "tax_id": 10116, "disease": "palmoplantar keratoderma and woolly hair (Disease Ontology:DOID:0070554); nephrotic syndrome type 16 (Disease Ontology:DOID:0080272); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:100361376)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;25961457;34502162", "class_list": "", "function": "Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (By similarity). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (By similarity). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (By similarity). Involved in the negative control of vitamin D receptor signaling pathway (By similarity). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (By similarity). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (By similarity). Through the Rho signaling pathway may also regulate cell proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0070563 negative regulation of vitamin D receptor signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D3ZD05-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZJ47-1", "uniprot_id": [ { "id": "MNAR1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZJ47", "type": "external" } ], "mass": 102819.0, "length": 917, "protein_name": "Major intrinsically disordered Notch2-binding receptor 1", "gene_name": "Minar1", "organism": "Rat", "refseq_name": "major intrinsically disordered Notch2-binding receptor 1", "refseq_ac": [ { "id": "NP_001363996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001363996", "type": "external" } ], "gene_names_uniprotkb": "Minar1; Ubtor", "gene_names_refseq": "Minar1", "protein_names_uniprotkb": "Major intrinsically disordered Notch2-binding receptor 1; Membrane integral NOTCH2-associated receptor 1; Ubiquitination and mTOR signaling protein", "protein_names_refseq": "major intrinsically disordered Notch2-binding receptor 1; ubiquitination and mTOR signaling protein", "tax_id": 10116, "disease": "", "pathway": " (rno:501033)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29393594;30080879", "class_list": "", "function": "Intrinsically disordered protein which may negatively regulate mTOR signaling pathway by stabilizing the mTOR complex component DEPTOR (PubMed:30080879). Negatively regulates angiogenesis (By similarity). Negatively regulates cell growth (By similarity). Negatively regulates neurite outgrowth in hippocampal neurons (PubMed:30080879)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0010977 negative regulation of neuron projection development;GO:0030308 negative regulation of cell growth;GO:0016525 negative regulation of angiogenesis;GO:0032007 negative regulation of TOR signaling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZJ47-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZJK7-1", "uniprot_id": [ { "id": "TBX6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZJK7", "type": "external" } ], "mass": 47216.0, "length": 436, "protein_name": "T-box transcription factor TBX6", "gene_name": "Tbx6", "organism": "Rat", "refseq_name": "T-box transcription factor TBX6", "refseq_ac": [ { "id": "NP_001102390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102390", "type": "external" } ], "gene_names_uniprotkb": "Tbx6", "gene_names_refseq": "Tbx6", "protein_names_uniprotkb": "T-box transcription factor TBX6; T-box protein 6", "protein_names_refseq": "T-box 6; T-box protein 6; T-box transcription factor TBX6", "tax_id": 10116, "disease": "scoliosis (Disease Ontology:DOID:0060249); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); spondylocostal dysostosis 5 (Disease Ontology:DOID:0112363)", "pathway": " (rno:365371)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to also play an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0014043 negative regulation of neuron maturation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZJK7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZKM3-1", "uniprot_id": [ { "id": "GP15L_RAT", "url": "https://www.uniprot.org/uniprot/D3ZKM3", "type": "external" } ], "mass": 8807.0, "length": 77, "protein_name": "Protein GPR15LG", "gene_name": "Gpr15lg", "organism": "Rat", "refseq_name": "protein GPR15LG precursor", "refseq_ac": [ { "id": "NP_001099533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099533", "type": "external" } ], "gene_names_uniprotkb": "Gpr15lg; Gpr15l", "gene_names_refseq": "Gpr15lg; Gpr15l", "protein_names_uniprotkb": "Protein GPR15LG; Protein GPR15 ligand; Protein GPR15L", "protein_names_refseq": "hypothetical gene supported by AF152002; protein GPR15 ligand; protein GPR15LG precursor; protein GPR15LG; protein GPR15L; secreted protein C10orf99 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:290595)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "28900043", "class_list": "", "function": "Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus., [UniProtKB, UniProtKB]; Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G protein-coupled receptor GPR15 (PubMed:28900043). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May regulate keratinocyte proliferation. In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0048018 receptor ligand activity;GO:0008009 chemokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0050830 defense response to Gram-positive bacterium;GO:0048247 lymphocyte chemotaxis;GO:0043029 T cell homeostasis;GO:0051782 negative regulation of cell division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZKM3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZKV9-1", "uniprot_id": [ { "id": "MSS51_RAT", "url": "https://www.uniprot.org/uniprot/D3ZKV9", "type": "external" } ], "mass": 52283.0, "length": 467, "protein_name": "Putative protein MSS51 homolog, mitochondrial", "gene_name": "Mss51", "organism": "Rat", "refseq_name": "putative protein MSS51 homolog, mitochondrial", "refseq_ac": [ { "id": "NP_001099495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099495", "type": "external" } ], "gene_names_uniprotkb": "Mss51; Zmynd17", "gene_names_refseq": "Mss51; Zmynd17", "protein_names_uniprotkb": "Putative protein MSS51 homolog, mitochondrial; Zinc finger MYND domain-containing protein 17", "protein_names_refseq": "MSS51 mitochondrial translational activator homolog; putative protein MSS51 homolog, mitochondrial; zinc finger MYND domain-containing protein 17; zinc finger, MYND domain containing 17; zinc finger, MYND-type containing 17", "tax_id": 10116, "disease": "", "pathway": " (rno:289904)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZKV9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZL52-1", "uniprot_id": [ { "id": "SESQ1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZL52", "type": "external" } ], "mass": 25793.0, "length": 234, "protein_name": "Sesquipedalian-1", "gene_name": "Pheta1", "organism": "Rat", "refseq_name": "sesquipedalian-1", "refseq_ac": [ { "id": "NP_001363745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001363745", "type": "external" } ], "gene_names_uniprotkb": "Pheta1; Fam109a", "gene_names_refseq": "Fam109a; IPIP27A; Pheta1; RGD1310656; Ses1", "protein_names_uniprotkb": "Sesquipedalian-1; 27 kDa inositol polyphosphate phosphatase interacting protein A; IPIP27A; PH domain-containing endocytic trafficking adaptor 1; Ses1", "protein_names_refseq": "27 kDa inositol polyphosphate phosphatase interacting protein A; family with sequence similarity 109, member A; sesquipedalian-1", "tax_id": 10116, "disease": "", "pathway": " (rno:288664)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20133602", "class_list": "", "function": "Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0055037 recycling endosome;GO:0030136 clathrin-coated vesicle;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0007032 endosome organization;GO:0001881 receptor recycling;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZL52-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZR35-1", "uniprot_id": [ { "id": "SIM13_RAT", "url": "https://www.uniprot.org/uniprot/D3ZR35", "type": "external" } ], "mass": 9995.0, "length": 88, "protein_name": "Small integral membrane protein 13", "gene_name": "Smim13", "organism": "Rat", "refseq_name": "small integral membrane protein 13", "refseq_ac": [ { "id": "NP_001129048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129048", "type": "external" } ], "gene_names_uniprotkb": "Smim13", "gene_names_refseq": "RGD1566043; Smim13", "protein_names_uniprotkb": "Small integral membrane protein 13", "protein_names_refseq": "UPF0766 protein C6orf228 homolog; rCG44158; small integral membrane protein 13", "tax_id": 10116, "disease": "", "pathway": " (rno:690806)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZR35-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZRK7-1", "uniprot_id": [ { "id": "D3ZRK7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZRK7", "type": "external" } ], "mass": 62313.0, "length": 561, "protein_name": "Cell division control protein", "gene_name": "Cdc6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cdc6", "gene_names_refseq": "", "protein_names_uniprotkb": "Cell division control protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "Meier-Gorlin syndrome (Disease Ontology:DOID:0060306); Meier-Gorlin syndrome 5 (Disease Ontology:DOID:0080516)", "pathway": " (rno:360621); (R-RNO-176187); (R-RNO-68689); (R-RNO-68949); (R-RNO-68962); (R-RNO-69017)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0051233 spindle midzone", "go_biological_process": "GO:0051984 positive regulation of chromosome segregation;GO:1904385 cellular response to angiotensin;GO:0051301 cell division;GO:1904117 cellular response to vasopressin;GO:0048146 positive regulation of fibroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZRK7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZSK5-1", "uniprot_id": [ { "id": "SETD6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZSK5", "type": "external" } ], "mass": 53362.0, "length": 474, "protein_name": "N-lysine methyltransferase SETD6", "gene_name": "Setd6", "organism": "Rat", "refseq_name": "N-lysine methyltransferase SETD6", "refseq_ac": [ { "id": "NP_001099637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099637", "type": "external" } ], "gene_names_uniprotkb": "Setd6", "gene_names_refseq": "RGD1560538; Setd6", "protein_names_uniprotkb": "N-lysine methyltransferase SETD6; 2.1.1.-; SET domain-containing protein 6", "protein_names_refseq": "N-lysine methyltransferase SETD6; SET domain-containing protein 6", "tax_id": 10116, "disease": "", "pathway": " (rno:291844); (R-RNO-3214841)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity). Methylates PAK4., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" } ], "go_molecular_function": "GO:0051059 NF-kappaB binding;GO:0016279 protein-lysine N-methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0048863 stem cell differentiation;GO:0050727 regulation of inflammatory response;GO:0019827 stem cell population maintenance;GO:0018026 peptidyl-lysine monomethylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZSK5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZT37-1", "uniprot_id": [ { "id": "TCAL7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZT37", "type": "external" } ], "mass": 11933.0, "length": 98, "protein_name": "Transcription elongation factor A protein-like 7", "gene_name": "Tceal7", "organism": "Rat", "refseq_name": "transcription elongation factor A protein-like 7", "refseq_ac": [ { "id": "NP_001102871", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102871", "type": "external" } ], "gene_names_uniprotkb": "Tceal7", "gene_names_refseq": "Tceal7", "protein_names_uniprotkb": "Transcription elongation factor A protein-like 7; TCEA-like protein 7; Transcription elongation factor S-II protein-like 7", "protein_names_refseq": "TCEA-like protein 7; transcription elongation factor A (SII)-like 7; transcription elongation factor A protein-like 7; transcription elongation factor S-II protein-like 7", "tax_id": 10116, "disease": "", "pathway": " (rno:680319)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZT37-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVK1-1", "uniprot_id": [ { "id": "MCM8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVK1", "type": "external" } ], "mass": 91977.0, "length": 830, "protein_name": "DNA helicase MCM8", "gene_name": "Mcm8", "organism": "Rat", "refseq_name": "DNA helicase MCM8 isoform a", "refseq_ac": [ { "id": "NP_001099984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099984", "type": "external" } ], "gene_names_uniprotkb": "Mcm8", "gene_names_refseq": "Mcm8", "protein_names_uniprotkb": "DNA helicase MCM8; 5.6.2.4; DNA 3'-5' helicase MCM8; Minichromosome maintenance 8", "protein_names_refseq": "DNA 3'-5' helicase MCM8; DNA helicase MCM8 isoform a; DNA helicase MCM8; DNA replication licensing factor MCM8; minichromosome maintenance complex component 8; minichromosome maintenance deficient 8", "tax_id": 10116, "disease": "primary ovarian insufficiency 10 (Disease Ontology:DOID:0080867)", "pathway": " (rno:296178); (R-RNO-176187); (R-RNO-68689); (R-RNO-68949); (R-RNO-68962)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates. Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs, probably by regulating the localization of the MNR complex. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Probably by regulating HR, plays a key role during gametogenesis. Stabilizes MCM9 protein., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005694 chromosome;GO:0097362 MCM8-MCM9 complex;GO:0042555 MCM complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0050821 protein stabilization;GO:0000724 double-strand break repair via homologous recombination;GO:0007292 female gamete generation;GO:0071168 protein localization to chromatin", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVK1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A1J9-1", "uniprot_id": [ { "id": "LRFN5_RAT", "url": "https://www.uniprot.org/uniprot/D4A1J9", "type": "external" } ], "mass": 79339.0, "length": 719, "protein_name": "Leucine-rich repeat and fibronectin type-III domain-containing protein 5", "gene_name": "Lrfn5", "organism": "Rat", "refseq_name": "leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor", "refseq_ac": [ { "id": "NP_001101494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101494", "type": "external" } ], "gene_names_uniprotkb": "Lrfn5; Salm5", "gene_names_refseq": "Lrfn5", "protein_names_uniprotkb": "Leucine-rich repeat and fibronectin type-III domain-containing protein 5", "protein_names_refseq": "leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor; leucine-rich repeat and fibronectin type-III domain-containing protein 5", "tax_id": 10116, "disease": "", "pathway": " (rno:314164)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18227064;38843836", "class_list": "", "function": "Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0009986 cell surface;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0050728 negative regulation of inflammatory response;GO:0043031 negative regulation of macrophage activation;GO:0099560 synaptic membrane adhesion;GO:1905606 regulation of presynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D4A1J9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A2H2-1", "uniprot_id": [ { "id": "SPTC1_RAT", "url": "https://www.uniprot.org/uniprot/D4A2H2", "type": "external" } ], "mass": 52549.0, "length": 473, "protein_name": "Serine palmitoyltransferase 1", "gene_name": "Sptlc1", "organism": "Rat", "refseq_name": "serine palmitoyltransferase 1", "refseq_ac": [ { "id": "NP_001101876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101876", "type": "external" } ], "gene_names_uniprotkb": "Sptlc1; Lcb1; rCG_44191", "gene_names_refseq": "LCB 1; Lcb1; RGD1306617; SPT 1; Spt1; Sptlc1", "protein_names_uniprotkb": "Serine palmitoyltransferase 1; 2.3.1.50; LCB 1; Long chain base biosynthesis protein 1; SPT 1; SPT1; Serine-palmitoyl-CoA transferase 1", "protein_names_refseq": "long chain base biosynthesis protein 1; serine palmitoyltransferase 1; serine palmitoyltransferase subunit 1; serine-palmitoyl-CoA transferase 1", "tax_id": 10116, "disease": "hereditary sensory and autonomic neuropathy (Disease Ontology:DOID:0050548); hereditary sensory and autonomic neuropathy type 1A (Disease Ontology:DOID:0070152); hereditary sensory and autonomic neuropathy type 1 (Disease Ontology:DOID:0070162); juvenile amyotrophic lateral sclerosis type 27 (Disease Ontology:DOID:0081381)", "pathway": " (rno:361213); (R-RNO-1660661)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11816724;18922131;21994399;25771159", "class_list": "", "function": "Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is also composed of SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer with SPTLC2 or SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (By similarity). Required for adipocyte cell viability and metabolic homeostasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data suggest that expression of enzymes involved in sphingolipid metabolism in skeletal muscle are regulated by dietary factors; here, caloric restriction down-regulates expression of Spt1 and Spt2 but up-regulates ceramide synthases (Cers1, Cers2)., [RefSeq, PubMed]; Marked upregulation of expression of both SPT subunits in actively proliferating cells in balloon-injured vessels(serine palmitoyltransferase 1)(serine palmitoyltransferase 2), [RefSeq, PubMed]; Sustained loss/reduction in SPT expression/activity promotes greater partitioning of palmitate towards diacylglycerol) synthesis, which impacts negatively upon insulin receptor substrate1-directed insulin signalling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.50", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.50", "type": "external" } ], "go_molecular_function": "GO:0004758 serine C-palmitoyltransferase activity;GO:0030170 pyridoxal phosphate binding", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0046511 sphinganine biosynthetic process;GO:0006688 glycosphingolipid biosynthetic process;GO:0046513 ceramide biosynthetic process;GO:0006665 sphingolipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D4A2H2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A7K7-1", "uniprot_id": [ { "id": "GP183_RAT", "url": "https://www.uniprot.org/uniprot/D4A7K7", "type": "external" } ], "mass": 40227.0, "length": 357, "protein_name": "G protein-coupled receptor 183", "gene_name": "Gpr183", "organism": "Rat", "refseq_name": "G-protein coupled receptor 183", "refseq_ac": [ { "id": "NP_001102856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102856", "type": "external" } ], "gene_names_uniprotkb": "Gpr183; Ebi2", "gene_names_refseq": "Ebi2; Gpr183", "protein_names_uniprotkb": "G protein-coupled receptor 183; EBI2; EBV-induced G protein-coupled receptor 2; Epstein-Barr virus-induced G protein-coupled receptor 2", "protein_names_refseq": "EBV-induced G-protein coupled receptor 2; Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor); G-protein coupled receptor 183; epstein-Barr virus-induced G-protein coupled receptor 2", "tax_id": 10116, "disease": "", "pathway": " (rno:679975); (R-RNO-373076); (R-RNO-418594)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "G protein-coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (By similarity). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (By similarity). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (By similarity). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (By similarity). Promotes osteoclast precursor migration to bone surfaces (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (By similarity). Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008142 oxysterol binding;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0002312 B cell activation involved in immune response;GO:0036145 dendritic cell homeostasis;GO:2000458 regulation of astrocyte chemotaxis;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A7K7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35800-1", "uniprot_id": [ { "id": "HIF1A_RAT", "url": "https://www.uniprot.org/uniprot/O35800", "type": "external" } ], "mass": 92319.0, "length": 825, "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "Hif1a", "organism": "Rat", "refseq_name": "hypoxia-inducible factor 1-alpha", "refseq_ac": [ { "id": "NP_077335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077335", "type": "external" } ], "gene_names_uniprotkb": "Hif1a", "gene_names_refseq": "HIF1-alpha; Hif1a; MOP1", "protein_names_uniprotkb": "Hypoxia-inducible factor 1-alpha; HIF-1-alpha; HIF1-alpha", "protein_names_refseq": "HIF1 alpha; hypoxia inducible factor 1 alpha subunit; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1-alpha", "tax_id": 10116, "disease": "limb ischemia (Disease Ontology:DOID:0050852); ductal carcinoma in situ (Disease Ontology:DOID:0060074); atrial fibrillation (Disease Ontology:DOID:0060224); alcohol-associated liver disease (Disease Ontology:DOID:0070658); polycystic kidney disease (Disease Ontology:DOID:0080322); osteonecrosis (Disease Ontology:DOID:10159); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); hypertension (Disease Ontology:DOID:10763); cholesteatoma of middle ear (Disease Ontology:DOID:10964); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); glycogen storage disease VII (Disease Ontology:DOID:11721); morbid obesity (Disease Ontology:DOID:11981); varicocele (Disease Ontology:DOID:12337); retinal ischemia (Disease Ontology:DOID:12510); hepatic encephalopathy (Disease Ontology:DOID:13413); bladder neck obstruction (Disease Ontology:DOID:13948); interstitial cystitis (Disease Ontology:DOID:13949); cancer (Disease Ontology:DOID:162); nephroblastoma (Disease Ontology:DOID:2154); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); glycogen storage disease V (Disease Ontology:DOID:2746); invasive ductal carcinoma (Disease Ontology:DOID:3008); acute kidney failure (Disease Ontology:DOID:3021); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); olfactory neuroblastoma (Disease Ontology:DOID:369); lung non-small cell carcinoma (Disease Ontology:DOID:3908); macular retinal edema (Disease Ontology:DOID:4449); renal cell carcinoma (Disease Ontology:DOID:4450); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); mycosis fungoides (Disease Ontology:DOID:8691); decubitus ulcer (Disease Ontology:DOID:8717); psoriasis (Disease Ontology:DOID:8893); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29560); (R-RNO-1234158); (R-RNO-1234174); (R-RNO-1234176); (R-RNO-5689880); (R-RNO-8857538); (R-RNO-8951664)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "11237857;11526200;38774964;38836656;38867145;38908346;39420031", "class_list": "", "function": "Aerobic exercise-induced HIF-1alpha upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease (By similarity). Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with NCOA1 and/or NCOA2. Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Hypoxia-inducible factor-1alpha attenuates renal podocyte injury in male rats in a simulated high-altitude environment by upregulating Kruppel-like factor 4 expression., [RefSeq, PubMed]; Nur77 induced by HIF-1alpha mediates vascular remodeling in hypoxic pulmonary hypertension. Publication Status: Online-Only, [RefSeq, PubMed]; Ultrasound-targeted microbubble destruction facilitates cartilage repair through increased the migration of mesenchymal stem cells via HIF-1alpha-mediated glycolysis pathway in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 50, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WTU9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0043279 response to alkaloid;GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0060574 intestinal epithelial cell maturation;GO:0071454 cellular response to anoxia;GO:1903672 positive regulation of sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35800-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AB66-1", "uniprot_id": [ { "id": "STON2_RAT", "url": "https://www.uniprot.org/uniprot/D4AB66", "type": "external" } ], "mass": 99491.0, "length": 895, "protein_name": "Stonin-2", "gene_name": "Ston2", "organism": "Rat", "refseq_name": "stonin-2", "refseq_ac": [ { "id": "NP_001129346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129346", "type": "external" } ], "gene_names_uniprotkb": "Ston2", "gene_names_refseq": "RGD1311502; Ston2", "protein_names_uniprotkb": "Stonin-2", "protein_names_refseq": "homolog of stoned B; stonin-2", "tax_id": 10116, "disease": "", "pathway": " (rno:314349); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "18200045;21102408;22727701;29393594", "class_list": "", "function": "Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating (By similarity)., [UniProtKB]; High-affinity ligand for the second EH domain (EH2) of the clathrin accessory protein Eps15., [RefSeq, PubMed]; Major adaptor for vesicle retrieval at hippocampal synapses, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0030136 clathrin-coated vesicle;GO:0043005 neuron projection;GO:0030122 AP-2 adaptor complex;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0030100 regulation of endocytosis;GO:0072583 clathrin-dependent endocytosis;GO:0002244 hematopoietic progenitor cell differentiation;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D4AB66-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ABX8-1", "uniprot_id": [ { "id": "LRFN4_RAT", "url": "https://www.uniprot.org/uniprot/D4ABX8", "type": "external" } ], "mass": 67259.0, "length": 636, "protein_name": "Leucine-rich repeat and fibronectin type-III domain-containing protein 4", "gene_name": "Lrfn4", "organism": "Rat", "refseq_name": "leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor", "refseq_ac": [ { "id": "NP_001102978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102978", "type": "external" } ], "gene_names_uniprotkb": "Lrfn4; Salm3", "gene_names_refseq": "Lrfn4", "protein_names_uniprotkb": "Leucine-rich repeat and fibronectin type-III domain-containing protein 4", "protein_names_refseq": "leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor; leucine-rich repeat and fibronectin type-III domain-containing protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:688721); (R-RNO-8849932)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "18227064;22673903;28222338;37592110;38843836", "class_list": "", "function": "POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by Hypermethylation-Mediated LRFN4 Downregulation Following Oxaliplatin Treatment., [RefSeq, PubMed]; Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity)., [UniProtKB]; SALM3 was expressed at significantly higher levels in the brains of epileptic rats compared to controls., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0009986 cell surface;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0099560 synaptic membrane adhesion;GO:1905606 regulation of presynapse assembly;GO:0099151 regulation of postsynaptic density assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "D4ABX8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ACP2-1", "uniprot_id": [ { "id": "SIM12_RAT", "url": "https://www.uniprot.org/uniprot/D4ACP2", "type": "external" } ], "mass": 10809.0, "length": 92, "protein_name": "Small integral membrane protein 12", "gene_name": "Smim12", "organism": "Rat", "refseq_name": "small integral membrane protein 12", "refseq_ac": [ { "id": "NP_001263412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263412", "type": "external" } ], "gene_names_uniprotkb": "Smim12", "gene_names_refseq": "Smim12", "protein_names_uniprotkb": "Small integral membrane protein 12", "protein_names_refseq": "small integral membrane protein 12", "tax_id": 10116, "disease": "", "pathway": " (rno:685634)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ACP2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AD37-1", "uniprot_id": [ { "id": "IMPA3_RAT", "url": "https://www.uniprot.org/uniprot/D4AD37", "type": "external" } ], "mass": 38569.0, "length": 356, "protein_name": "Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase", "gene_name": "Bpnt2", "organism": "Rat", "refseq_name": "Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase", "refseq_ac": [ { "id": "NP_001008772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008772", "type": "external" } ], "gene_names_uniprotkb": "Bpnt2; Impa3; Impad1", "gene_names_refseq": "Bpnt2; IMP 3; Impad1; RGD1306455; gPAPP", "protein_names_uniprotkb": "Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; 3'(2'), 5'-bisphosphate nucleotidase 2; 3.1.3.7; Golgi-resident PAP phosphatase; Inositol monophosphatase domain-containing protein 1; Myo-inositol monophosphatase A3; Phosphoadenosine phosphate 3'-nucleotidase; gPAPP", "protein_names_refseq": "Ac2-190; Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase; Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; IMPase 3; golgi-resident PAP phosphatase; inositol monophosphatase 3; inositol monophosphatase domain containing 1; inositol monophosphatase domain-containing protein 1; inositol-1(or 4)-monophosphatase 3; myo-inositol monophosphatase A3; phosphoadenosine phosphate 3'-nucleotidase", "tax_id": 10116, "disease": "chondrodysplasia with joint dislocations gPAPP type (Disease Ontology:DOID:0112224)", "pathway": " (rno:312952); (R-RNO-156584)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.7", "type": "external" }, { "id": "3.1.3.57", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.57", "type": "external" } ], "go_molecular_function": "GO:0008254 3'-nucleotidase activity;GO:0097657 3',5'-nucleotide bisphosphate phosphatase activity;GO:0046872 metal ion binding;GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032588 trans-Golgi network membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0001501 skeletal system development;GO:0009791 post-embryonic development;GO:0042733 embryonic digit morphogenesis;GO:0001958 endochondral ossification;GO:0002063 chondrocyte development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AD37-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C865-1", "uniprot_id": [ { "id": "MK07_RAT", "url": "https://www.uniprot.org/uniprot/P0C865", "type": "external" } ], "mass": 87827.0, "length": 806, "protein_name": "Mitogen-activated protein kinase 7", "gene_name": "Mapk7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mapk7; Bmk1; Erk5", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitogen-activated protein kinase 7; 2.7.11.24; BMK-1; Big MAP kinase 1; ERK-5; Extracellular signal-regulated kinase 5; MAP kinase 7; MAPK 7", "protein_names_refseq": "", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (rno:114509); (R-RNO-198753); (R-RNO-198765); (R-RNO-202670); (R-RNO-2559582); (R-RNO-881907); (R-RNO-8853659)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "20724525;23428871;9753748", "class_list": "", "function": "Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (PubMed:20724525). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression (By similarity). Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0051019 mitogen-activated protein kinase binding;GO:0004707 MAP kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016605 PML body", "go_biological_process": "GO:0070375 ERK5 cascade;GO:0070377 negative regulation of ERK5 cascade;GO:0006468 protein phosphorylation;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0C865-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21775-1", "uniprot_id": [ { "id": "THIKA_RAT", "url": "https://www.uniprot.org/uniprot/P21775", "type": "external" } ], "mass": 44839.0, "length": 434, "protein_name": "3-ketoacyl-CoA thiolase A, peroxisomal", "gene_name": "Acaa1a", "organism": "Rat", "refseq_name": "3-ketoacyl-CoA thiolase A, peroxisomal isoform 1", "refseq_ac": [ { "id": "NP_036621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036621", "type": "external" } ], "gene_names_uniprotkb": "Acaa1a; Acaa1", "gene_names_refseq": "Acaa1a; Acaa1; Acaa; Pktaa", "protein_names_uniprotkb": "3-ketoacyl-CoA thiolase A, peroxisomal; 2.3.1.155; 2.3.1.16; 2.3.1.9; Acetyl-CoA C-myristoyltransferase; Acetyl-CoA acyltransferase A; Beta-ketothiolase A; Peroxisomal 3-oxoacyl-CoA thiolase A; Thiolase A", "protein_names_refseq": "3-ketoacyl-CoA thiolase A, peroxisomal isoform 1; 3-ketoacyl-CoA thiolase A, peroxisomal; Acetyl-CoA acyltransferase 3-oxo acyl-CoA thiolase A peroxisomal; acetyl-CoA C-myristoyltransferase; acetyl-CoA acyltransferase 1; acetyl-CoA acyltransferase 3-oxo acyl-CoA thiolase A 1 peroxisomal; acetyl-CoA acyltransferase A; acetyl-CoA acyltransferase, 3-oxo acyl-CoA thiolase A; acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase); acetyl-Coenzyme A acyltransferase 1A; beta-ketothiolase A; peroxisomal 3-oxoacyl-CoA thiolase A", "tax_id": 10116, "disease": "", "pathway": " (rno:24157)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1680677;2210380;2307679;9325339", "class_list": "", "function": "Responsible for the thiolytic cleavage of straight chain 3-keto fatty acyl-CoAs (3-oxoacyl-CoAs) (PubMed:9325339). Plays an important role in fatty acid peroxisomal beta-oxidation (PubMed:9325339). Catalyzes the cleavage of short, medium, long, and very long straight chain 3-oxoacyl-CoAs (PubMed:9325339). Medium chain straight 3-oxoacyl-CoAs are preferred substrates (PubMed:9325339)., [UniProtKB, PubMed]; Responsible for the thiolytic cleavage of straight chain 3-keto fatty acyl-CoAs (3-oxoacyl-CoAs). Plays an important role in fatty acid peroxisomal beta-oxidation. Catalyzes the cleavage of short, medium, long, and very long straight chain 3-oxoacyl-CoAs. Medium chain straight 3-oxoacyl-CoAs are preferred substrates., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FVR9", "ec_number_list": [ { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" } ], "go_molecular_function": "GO:0003988 acetyl-CoA C-acyltransferase activity;GO:0003985 acetyl-CoA C-acetyltransferase activity;GO:0008775 acetate CoA-transferase activity;GO:0050633 acetyl-CoA C-myristoyltransferase activity;GO:0120524 long-chain fatty acyl-CoA oxidase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0010124 phenylacetate catabolic process;GO:0000038 very long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0007584 response to nutrient;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P21775-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18113-1", "uniprot_id": [ { "id": "THB_RAT", "url": "https://www.uniprot.org/uniprot/P18113", "type": "external" } ], "mass": 52656.0, "length": 461, "protein_name": "Thyroid hormone receptor beta", "gene_name": "Thrb", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Thrb; Erba2; Nr1a2", "gene_names_refseq": "", "protein_names_uniprotkb": "Thyroid hormone receptor beta; Nuclear receptor subfamily 1 group A member 2; c-erbA-2; c-erbA-beta", "protein_names_refseq": "", "tax_id": 10116, "disease": "selective pituitary thyroid hormone resistance (Disease Ontology:DOID:0111374); prostate cancer (Disease Ontology:DOID:10283); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); thyroid hormone resistance syndrome (Disease Ontology:DOID:11633); breast cancer (Disease Ontology:DOID:1612); breast carcinoma (Disease Ontology:DOID:3459); follicular thyroid carcinoma (Disease Ontology:DOID:3962); renal cell carcinoma (Disease Ontology:DOID:4450); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (rno:24831); (R-RNO-383280); (R-RNO-4090294)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "20078863;20610536;2457590;2539642;2899322", "class_list": "", "function": "Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P37826", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0007621 negative regulation of female receptivity;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P18113-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35952-1", "uniprot_id": [ { "id": "GLO2_RAT", "url": "https://www.uniprot.org/uniprot/O35952", "type": "external" } ], "mass": 34109.0, "length": 309, "protein_name": "Hydroxyacylglutathione hydrolase, mitochondrial", "gene_name": "Hagh", "organism": "Rat", "refseq_name": "hydroxyacylglutathione hydrolase, mitochondrial isoform a precursor", "refseq_ac": [ { "id": "NP_203500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_203500", "type": "external" } ], "gene_names_uniprotkb": "Hagh; Rsp29", "gene_names_refseq": "Glo2; Hagh; RSP29", "protein_names_uniprotkb": "Hydroxyacylglutathione hydrolase, mitochondrial; 3.1.2.6; Glx II; Glyoxalase II; Round spermatid protein RSP29", "protein_names_refseq": "glx II; glyoxalase II; hydroxyacylglutathione hydrolase, mitochondrial isoform a precursor; hydroxyacylglutathione hydrolase, mitochondrial; round spermatid protein RSP29", "tax_id": 10116, "disease": "", "pathway": " (rno:24439); (R-RNO-70268)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22893478;8719777;9434774", "class_list": "", "function": "Changes in glyoxalase 1 and glyoxalase 2 activities and the development of diabetic complications in experimental animal models of obesity., [RefSeq, PubMed]; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V8M8", "ec_number_list": [ { "id": "3.1.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.6", "type": "external" } ], "go_molecular_function": "GO:0004416 hydroxyacylglutathione hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione;GO:0007283 spermatogenesis;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O35952-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88280-1", "uniprot_id": [ { "id": "SLIT3_RAT", "url": "https://www.uniprot.org/uniprot/O88280", "type": "external" } ], "mass": 167768.0, "length": 1523, "protein_name": "Slit homolog 3 protein", "gene_name": "Slit3", "organism": "Rat", "refseq_name": "slit homolog 3 protein precursor", "refseq_ac": [ { "id": "NP_112611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112611", "type": "external" } ], "gene_names_uniprotkb": "Slit3; Megf5", "gene_names_refseq": "Megf5; Slit3", "protein_names_uniprotkb": "Slit homolog 3 protein; Multiple EGF-like domains protein 5; Multiple epidermal growth factor-like domains protein 5; Slit-3", "protein_names_refseq": "multiple EGF-like domains protein 5; multiple epidermal growth factor-like domains 5; multiple epidermal growth factor-like domains protein 5; slit homolog 3 protein precursor; slit homolog 3 protein; slit-3", "tax_id": 10116, "disease": "congenital diaphragmatic hernia (Disease Ontology:DOID:3827)", "pathway": " (rno:83467)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11754167;28363469;35318077;38843836;9693030", "class_list": "", "function": "Angelica sinensis polysaccharide improves rheumatoid arthritis by modifying the expression of intestinal Cldn5, Slit3 and Rgs18 through gut microbiota., [RefSeq, PubMed]; May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Relative mRNA expression of Ndst1 and Slit3 was significantly decreased in pleuroperitoneal folds, developing diaphragms and fully muscularized diaphragms, and endothelial cells within the diaphragmatic vasculature of nitrofen-exposed fetuses compared to controls., [RefSeq, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005509 calcium ion binding;GO:0048495 Roundabout binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030054 cell junction;GO:0005576 extracellular region", "go_biological_process": "GO:0070100 negative regulation of chemokine-mediated signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0010629 negative regulation of gene expression;GO:0021510 spinal cord development;GO:0032870 cellular response to hormone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88280-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88279-1", "uniprot_id": [ { "id": "SLIT1_RAT", "url": "https://www.uniprot.org/uniprot/O88279", "type": "external" } ], "mass": 167499.0, "length": 1531, "protein_name": "Slit homolog 1 protein", "gene_name": "Slit1", "organism": "Rat", "refseq_name": "slit homolog 1 protein precursor", "refseq_ac": [ { "id": "NP_075242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075242", "type": "external" } ], "gene_names_uniprotkb": "Slit1; Megf4", "gene_names_refseq": "MEGF4; Slit1", "protein_names_uniprotkb": "Slit homolog 1 protein; Multiple EGF-like domains protein 4; Multiple epidermal growth factor-like domains protein 4; Slit-1", "protein_names_refseq": "multiple EGF-like domains protein 4; multiple epidermal growth factor-like domains 4; multiple epidermal growth factor-like domains protein 4; slit homolog 1 protein precursor; slit homolog 1 protein; slit-1", "tax_id": 10116, "disease": "", "pathway": " (rno:65047)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10102268;10864956;11754167;15528323;18755265;20172023;34652618;38843836;9693030;9813312", "class_list": "", "function": "Expression of Slit and Robo during remodeling of corticospinal tract in cervical spinal cord in middle cerebral artery occlusion rats., [RefSeq, PubMed]; The difference in expression pattern of Slit family mRNA in the neurons during peripheral nerve regeneration suggests that it plays a different role in axonal regeneration after axotomy of peripheral nerves, [RefSeq, PubMed]; These findings indicate that Slit1/Robo2 signaling may have a role in regulating peripheral nerve regeneration., [RefSeq, PubMed]; Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 14, "predicted_n_glycosites": 13, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q8CJG8;Q8CJG9;Q8CJH0;Q9QWL1;Q9WUG5", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0005509 calcium ion binding;GO:0048495 Roundabout binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007409 axonogenesis;GO:0021510 spinal cord development;GO:0048812 neuron projection morphogenesis;GO:0050919 negative chemotaxis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O88279-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000001000.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C6B1-1", "uniprot_id": [ { "id": "S35E1_RAT", "url": "https://www.uniprot.org/uniprot/P0C6B1", "type": "external" } ], "mass": 44384.0, "length": 409, "protein_name": "Solute carrier family 35 member E1", "gene_name": "Slc35e1", "organism": "Rat", "refseq_name": "solute carrier family 35 member E1", "refseq_ac": [ { "id": "NP_001102577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102577", "type": "external" } ], "gene_names_uniprotkb": "Slc35e1", "gene_names_refseq": "RGD1561342; Slc35e1", "protein_names_uniprotkb": "Solute carrier family 35 member E1", "protein_names_refseq": "solute carrier family 35 member E1", "tax_id": 10116, "disease": "", "pathway": " (rno:498599)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative transporter., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C6B1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35548-1", "uniprot_id": [ { "id": "MMP16_RAT", "url": "https://www.uniprot.org/uniprot/O35548", "type": "external" } ], "mass": 69624.0, "length": 607, "protein_name": "Matrix metalloproteinase-16", "gene_name": "Mmp16", "organism": "Rat", "refseq_name": "matrix metalloproteinase-16 precursor", "refseq_ac": [ { "id": "NP_542954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542954", "type": "external" } ], "gene_names_uniprotkb": "Mmp16", "gene_names_refseq": "Mmp16; Mt3-mmp", "protein_names_uniprotkb": "Matrix metalloproteinase-16; 3.4.24.-; MMP-16; MT-MMP 3; MT3-MMP; MT3MMP; MTMMP3; Membrane-type matrix metalloproteinase 3; Membrane-type-3 matrix metalloproteinase", "protein_names_refseq": "MMP-16; MT-MMP 3; MT3MMP; MTMMP3; matrix metalloproteinase-16 precursor; matrix metalloproteinase-16; membrane-type matrix metalloproteinase 3; membrane-type-3 matrix metalloproteinase", "tax_id": 10116, "disease": "", "pathway": " (rno:65205); (R-RNO-1592389); (R-RNO-9839383)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "18784838;9092507", "class_list": "", "function": "Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. The short isoform efficiently converts progelatinase A to the intermediate form but not to the mature one. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells., [UniProtKB]; MMP16 polymorphisms appear to influence not only the pulmonary expression and function of MMP16 but also the risk of bronchopulmonary dysplasia Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35541", "ec_number_list": [ { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.80", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.80", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0097094 craniofacial suture morphogenesis;GO:0006508 proteolysis;GO:0016485 protein processing;GO:0030198 extracellular matrix organization;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35548-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47868-1", "uniprot_id": [ { "id": "SCG3_RAT", "url": "https://www.uniprot.org/uniprot/P47868", "type": "external" } ], "mass": 53183.0, "length": 471, "protein_name": "Secretogranin-3", "gene_name": "Scg3", "organism": "Rat", "refseq_name": "secretogranin-3 precursor", "refseq_ac": [ { "id": "NP_446308", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446308", "type": "external" } ], "gene_names_uniprotkb": "Scg3", "gene_names_refseq": "Scg3; SgIII", "protein_names_uniprotkb": "Secretogranin-3; 1B1075; Secretogranin III; SgIII", "protein_names_refseq": "1B1075; secretogranin-3 precursor; secretogranin-3", "tax_id": 10116, "disease": "", "pathway": " (rno:116635); (R-RNO-114608); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "12388744;14597614;15125023;16219686;18483175;18802106;2204688;22673903;7917832", "class_list": "", "function": "A small amount of secretogranin III is able to sort chromogranin A aggregates together with adrenomedullin to secretory granules., [RefSeq, PubMed]; In mast cells, a secretogranin III-chromogranin A complex may play a key role in secretory granule biogenesis., [RefSeq, PubMed]; Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:12388744, PubMed:14597614). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (PubMed:12388744, PubMed:14597614). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; SgIII and CPE form the separate functional sorting complex by anchoring to cholesterol-rich SG membranes, and POMC-derived peptides are transferred from CPE to SgIII, and subsequently to CgA., [RefSeq, PubMed]; SgIII directly binds to cholesterol components of the secretory granule membrane and targets chromogranin A to secretory granules in pituitary and pancreatic endocrine cells, [RefSeq, PubMed]; SgIII is closely associated with the secretory granule membrane, serving to anchor the aggregates of other soluble constituents to the membrane., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0030658 transport vesicle membrane;GO:0030667 secretory granule membrane", "go_biological_process": "GO:0033366 protein localization to secretory granule", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P47868-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C152-1", "uniprot_id": [ { "id": "MKS3_RAT", "url": "https://www.uniprot.org/uniprot/P0C152", "type": "external" } ], "mass": 111740.0, "length": 992, "protein_name": "Meckelin", "gene_name": "Tmem67", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tmem67; Mks3; Wpk", "gene_names_refseq": "", "protein_names_uniprotkb": "Meckelin; Meckel syndrome type 3 protein homolog; Transmembrane protein 67", "protein_names_refseq": "", "tax_id": 10116, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); Meckel syndrome (Disease Ontology:DOID:0050778); ciliopathy (Disease Ontology:DOID:0060340); Meckel syndrome 3 (Disease Ontology:DOID:0070117); Bardet-Biedl syndrome 14 (Disease Ontology:DOID:0110136); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); Joubert syndrome 6 (Disease Ontology:DOID:0111001); nephronophthisis 11 (Disease Ontology:DOID:0111118); COACH syndrome (Disease Ontology:DOID:0111589); portal hypertension (Disease Ontology:DOID:10762); meningocele (Disease Ontology:DOID:1088); hydrocephalus (Disease Ontology:DOID:10908); coloboma (Disease Ontology:DOID:12270); nephronophthisis (Disease Ontology:DOID:12712); communicating hydrocephalus (Disease Ontology:DOID:1573); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); cystic kidney disease (Disease Ontology:DOID:2975); proteinuria (Disease Ontology:DOID:576)", "pathway": " (rno:313067); (R-RNO-5620912)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11095650;16415887;19515853;19815549", "class_list": "", "function": "Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Is a key regulator of stereociliary bundle orientation. Required for epithelial cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (sftpc) (By similarity). Involved in the negative regulation of canonical Wnt signaling, and activation of the non-canonical cascade stimulated by WNT5A (By similarity). In non-canonical Wnt signaling, it may act as ROR2 coreceptor (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051787 misfolded protein binding;GO:0031005 filamin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005789 endoplasmic reticulum membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0005930 axoneme;GO:0036038 MKS complex", "go_biological_process": "GO:0007507 heart development;GO:0001822 kidney development;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0035845 photoreceptor cell outer segment organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P0C152-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88457-1", "uniprot_id": [ { "id": "SCNBA_RAT", "url": "https://www.uniprot.org/uniprot/O88457", "type": "external" } ], "mass": 201845.0, "length": 1765, "protein_name": "Sodium channel protein type 11 subunit alpha", "gene_name": "Scn11a", "organism": "Rat", "refseq_name": "sodium channel protein type 11 subunit alpha", "refseq_ac": [ { "id": "NP_062138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062138", "type": "external" } ], "gene_names_uniprotkb": "Scn11a; Nan; Sns2", "gene_names_refseq": "NaN; Scn11a", "protein_names_uniprotkb": "Sodium channel protein type 11 subunit alpha; NaN; Sensory neuron sodium channel 2; Sodium channel protein type XI subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.9", "protein_names_refseq": "sensory neuron sodium channel 2; sodium channel protein type 11 subunit alpha; sodium channel protein type XI subunit alpha; sodium channel, voltage-gated, type 11, alpha polypeptide; sodium channel, voltage-gated, type XI, alpha polypeptide; sodium channel, voltage-gated, type XI, alpha subunit; sodium channel, voltage-gated, type11, alpha polypeptide; voltage-gated sodium channel NAV1.9b; voltage-gated sodium channel subunit alpha Nav1.9", "tax_id": 10116, "disease": "hereditary sensory and autonomic neuropathy (Disease Ontology:DOID:0050548); generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); hereditary sensory and autonomic neuropathy type 7 (Disease Ontology:DOID:0070149); Dravet syndrome (Disease Ontology:DOID:0080422); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); familial episodic pain syndrome 3 (Disease Ontology:DOID:0111731); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:29701)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10196578;11487631;11972999;12536125;24507022;24732443;25959819;28913981;29388177;9671787", "class_list": "", "function": "Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB]; Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system. Also involved in rapid BDNF-evoked neuronal depolarization., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; The effects of insecticides and pyridostimine bromide on the exprssion of Nav1.9 in muscle and vascular nociceptors is reported., [RefSeq, PubMed]; The mRNA expression of the SCN11a gene (which encodes the Nav1.9 channel) in mPFC tissue was significantly higher in young rats than in late adolescent and adult rats., [RefSeq, PubMed]; The pattern of expression of the voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models., [RefSeq, PubMed]; The protein expressions of voltage-gated sodium channels (VGSCs) alpha-subunits Nav1.3, Nav1.7 and Nav1.9 increased in dorsal root ganglionof diabetic rats and were normalized by TIIA application., [RefSeq, PubMed]; Verapamil and lidocaine significantly reduce the degree of ischemia-reperfusion injury due to effects to TRPM and Nav1.9 genes, [RefSeq, PubMed]; We conclude that Nav1.9 acts as a subthreshold amplifier in cold-sensitive nociceptive neurons and is required for the perception of cold pain under normal and pathological conditions., [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0017134 fibroblast growth factor binding;GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0044297 cell body", "go_biological_process": "GO:0060538 skeletal muscle organ development;GO:0070417 cellular response to cold;GO:0061368 behavioral response to formalin induced pain;GO:0060004 reflex;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O88457-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52296-1", "uniprot_id": [ { "id": "IMB1_RAT", "url": "https://www.uniprot.org/uniprot/P52296", "type": "external" } ], "mass": 97124.0, "length": 875, "protein_name": "Importin subunit beta-1", "gene_name": "Kpnb1", "organism": "Rat", "refseq_name": "importin subunit beta-1", "refseq_ac": [ { "id": "NP_058759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058759", "type": "external" } ], "gene_names_uniprotkb": "Kpnb1", "gene_names_refseq": "Impnb; Kpnb1", "protein_names_uniprotkb": "Importin subunit beta-1; Karyopherin subunit beta-1; Nuclear factor p97; PTAC97; Pore targeting complex 97 kDa subunit", "protein_names_refseq": "Importin beta; PTAC97; importin subunit beta-1; karyopherin (importin) beta 1; karyopherin,beta 1; nuclear factor P97; pore targeting complex 97 kDa subunit", "tax_id": 10116, "disease": "spondylocostal dysostosis (Disease Ontology:DOID:0050568); spondylocostal dysostosis 1 (Disease Ontology:DOID:0112365); dysostosis (Disease Ontology:DOID:1934)", "pathway": " (rno:24917); (R-RNO-140342); (R-RNO-1655829); (R-RNO-2995383); (R-RNO-6798695); (R-RNO-68616); (R-RNO-909733)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "7604027;7878057", "class_list": "", "function": "Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. In association with IPO7, mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Imports MRTFA, SNAI1 and PRKCI into the nucleus., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061676 importin-alpha family protein binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0007079 mitotic chromosome movement towards spindle pole;GO:0006610 ribosomal protein import into nucleus;GO:0090307 mitotic spindle assembly;GO:0007080 mitotic metaphase chromosome alignment;GO:0040001 establishment of mitotic spindle localization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P52296-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13721-1", "uniprot_id": [ { "id": "SIAT1_RAT", "url": "https://www.uniprot.org/uniprot/P13721", "type": "external" } ], "mass": 46754.0, "length": 403, "protein_name": "Beta-galactoside alpha-2,6-sialyltransferase 1", "gene_name": "St6gal1", "organism": "Rat", "refseq_name": "beta-galactoside alpha-2,6-sialyltransferase 1 isoform 1", "refseq_ac": [ { "id": "NP_001106815", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106815", "type": "external" } ], "gene_names_uniprotkb": "St6gal1; Siat1", "gene_names_refseq": "Siat1; St6gal1", "protein_names_uniprotkb": "Beta-galactoside alpha-2,6-sialyltransferase 1; 2.4.3.1; Alpha 2,6-ST 1; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; ST6Gal I; ST6GalI; Sialyltransferase 1", "protein_names_refseq": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 6-sialyltransferase 1; ST6 beta-galactosamide alpha-2,6-sialyltranferase 1; ST6Gal I; ST6GalI; Sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase); Sialyltransferase 1 (beta-galactoside alpha-26-sialytransferase); alpha 2,6-ST 1; beta-galactoside alpha-2,6-sialyltransferase 1 isoform 1; beta-galactoside alpha-2,6-sialyltransferase 1", "tax_id": 10116, "disease": "pterygium (Disease Ontology:DOID:0002116); bone disease (Disease Ontology:DOID:0080001); COVID-19 (Disease Ontology:DOID:0080600); Parkinsonism (Disease Ontology:DOID:0080855); multiple endocrine neoplasia type 1 (Disease Ontology:DOID:10017); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); corneal neovascularization (Disease Ontology:DOID:11382); leiomyoma (Disease Ontology:DOID:127); endometrial cancer (Disease Ontology:DOID:1380); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); retinal vein occlusion (Disease Ontology:DOID:1727); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); ovarian cancer (Disease Ontology:DOID:2394); prostate adenocarcinoma (Disease Ontology:DOID:2526); transitional cell carcinoma (Disease Ontology:DOID:2671); dermatitis (Disease Ontology:DOID:2723); high grade glioma (Disease Ontology:DOID:3070); coronary artery disease (Disease Ontology:DOID:3393); breast carcinoma (Disease Ontology:DOID:3459); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); bladder disease (Disease Ontology:DOID:365); macular retinal edema (Disease Ontology:DOID:4449); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); esophageal cancer (Disease Ontology:DOID:5041); pulmonary hypertension (Disease Ontology:DOID:6432); cocaine abuse (Disease Ontology:DOID:809); cataract (Disease Ontology:DOID:83); chronic ulcer of skin (Disease Ontology:DOID:8549); decubitus ulcer (Disease Ontology:DOID:8717); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); biliary tract disease (Disease Ontology:DOID:9741); diabetic neuropathy (Disease Ontology:DOID:9743); polyarteritis nodosa (Disease Ontology:DOID:9810)", "pathway": " (rno:25197); (R-RNO-4085001); (R-RNO-975577); (R-RNO-977068)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "11278697;1733948;1983783;21098517;21454685;21930713;24155237;2793863;3121604", "class_list": "glycogene;glycosyltransferase", "function": "Comparisons of the structure with pig ST3GAL1 and a bacterial sialyltransferase revealed a similar positioning of donor, acceptor, and catalytic residues that provide a common structural framework for catalysis, [RefSeq, PubMed]; Rat ST6GAL1 mRNA possess an L exon, suggesting conservation of this regulatory element in rodents, [RefSeq, PubMed]; ST6Gal-I regulates macrophage apoptosis via alpha2-6 sialylation of the TNFR1 death receptor., [RefSeq, PubMed]; Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates (PubMed:11278697, PubMed:24155237, PubMed:3121604). Sialylates complex-type N-glycans attached on the fragment crystallizable (Fc) of IgGs confering anti-inflammatory effector functions. Preferentially monosialylates the alpha(1->3) mannose antenna of Fc glycoforms with subsequent disialylation occurring at a much slower rate (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. Sialylates complex-type N-glycans attached on the fragment crystallizable (Fc) of IgGs confering anti-inflammatory effector functions. Preferentially monosialylates the alpha(1->3) mannose antenna of Fc glycoforms with subsequent disialylation occurring at a much slower rate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 20, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 43, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D4ABR2;G3V680", "ec_number_list": [ { "id": "2.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.1", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0008373 sialyltransferase activity;GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane;GO:0005797 Golgi medial cisterna", "go_biological_process": "GO:0032946 positive regulation of mononuclear cell proliferation;GO:1900024 regulation of substrate adhesion-dependent cell spreading;GO:0006054 N-acetylneuraminate metabolic process;GO:0050922 negative regulation of chemotaxis;GO:0045471 response to ethanol", "synthesized_glycan_count": 1722, "hit_score": 1.2, "record_id": "P13721-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000000000001.100.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30836-1", "uniprot_id": [ { "id": "LYAM1_RAT", "url": "https://www.uniprot.org/uniprot/P30836", "type": "external" } ], "mass": 42441.0, "length": 372, "protein_name": "L-selectin", "gene_name": "Sell", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sell; Lnhr; Ly-22", "gene_names_refseq": "", "protein_names_uniprotkb": "L-selectin; CD62 antigen-like family member L; LAM-1; LECAM1; Leukocyte adhesion molecule 1; Leukocyte-endothelial cell adhesion molecule 1; Ly-22; Lymph node homing receptor; Lymphocyte antigen 22; Lymphocyte surface MEL-14 antigen", "protein_names_refseq": "", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); graft-versus-host disease (Disease Ontology:DOID:0081267); Alzheimer's disease (Disease Ontology:DOID:10652); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); toxic shock syndrome (Disease Ontology:DOID:14115); alcohol use disorder (Disease Ontology:DOID:1574); hepatitis (Disease Ontology:DOID:2237); endometriosis (Disease Ontology:DOID:289); IgA glomerulonephritis (Disease Ontology:DOID:2986); peripheral vascular disease (Disease Ontology:DOID:341); pancreatitis (Disease Ontology:DOID:4989); ureteral obstruction (Disease Ontology:DOID:5199); abdominal aortic aneurysm (Disease Ontology:DOID:7693); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (R-RNO-198933); (R-RNO-202733); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "1378303", "class_list": "", "function": "Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0002020 protease binding;GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding;GO:0033691 sialic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0034201 response to oleic acid;GO:0045471 response to ethanol;GO:0034097 response to cytokine;GO:0042981 regulation of apoptotic process;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P30836-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02780-1", "uniprot_id": [ { "id": "SG2A2_RAT", "url": "https://www.uniprot.org/uniprot/P02780", "type": "external" } ], "mass": 10731.0, "length": 95, "protein_name": "Secretoglobin family 2A member 2", "gene_name": "Scgb2a1; Scgb2a2", "organism": "Rat", "refseq_name": "secretoglobin family 2A member 2 precursor", "refseq_ac": [ { "id": "NP_976078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_976078", "type": "external" } ], "gene_names_uniprotkb": "Scgb2a1; Scgb2a2; Psbpc3", "gene_names_refseq": "C3.1; Psbp1; Psbpc3; Scgb2a1; Scgb2a2", "protein_names_uniprotkb": "Secretoglobin family 2A member 2; C3.1; Prostatein peptide C3; Prostatic steroid-binding protein C3", "protein_names_refseq": "androgen receptor DNA-binding domain DNA; prostatein C3 subunit; prostatein peptide C3; prostatic steroid-binding protein 1; prostatic steroid-binding protein C3.2; prostatic steroid-binding protein C3; secretoglobin family 2A member 2 precursor; secretoglobin, family 2A, member 2", "tax_id": 10116, "disease": "", "pathway": " (rno:361725)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1537831;6190812;6294095;6685625;7014218", "class_list": "", "function": "Part of prostatein which is the major secretory glycoprotein of ventral prostate gland. Steroid-binding protein; can bind non-polar steroids, cholesterol and a group of small proline-rich peptides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63463", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0005496 steroid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0030521 androgen receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P02780-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54835-1", "uniprot_id": [ { "id": "SMAD9_RAT", "url": "https://www.uniprot.org/uniprot/O54835", "type": "external" } ], "mass": 48992.0, "length": 434, "protein_name": "SMAD family member 9", "gene_name": "Smad9", "organism": "Rat", "refseq_name": "SMAD family member 9", "refseq_ac": [ { "id": "NP_620227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620227", "type": "external" } ], "gene_names_uniprotkb": "Smad9; Madh8; Madh9; Smad8", "gene_names_refseq": "Madh9; Smad8; Smad9", "protein_names_uniprotkb": "SMAD family member 9; MAD homolog 9; Mothers against DPP homolog 9; Mothers against decapentaplegic homolog 9; SMAD 9", "protein_names_refseq": "MAD homolog 9; SMAD 9; SMAD family member 9; mothers against DPP homolog 9; mothers against decapentaplegic homolog 9", "tax_id": 10116, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); prostate cancer (Disease Ontology:DOID:10283); primary pulmonary hypertension (Disease Ontology:DOID:14557); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:85435); (R-RNO-201451)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21515935;26687945;27035233;9371779", "class_list": "", "function": "Biomechanical stimulation of osteoblasts activates SMAD 1/5/8 in the BMP signaling pathway through BMPR1 and may enhance osteogenesis by upregulating SMAD-dependent osteogenic genes, [RefSeq, PubMed]; Cpd 861 markedly upregulated the gene expression of BMP7 and Smad5, as well as the protein expression of BMP7 and Smad1/5. In addition, p-Smad1/5/8 protein expression was markedly increased by Cpd 861 in the liver fibrosis model., [RefSeq, PubMed]; Taken together, these results indicated that FSTL1 protects the SNP-induced injury in cardiac H9c2 cells through, at least in part, the activation of Akt and inhibition of Smad1/5/9 signaling., [RefSeq, PubMed]; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD) (By similarity). Has been shown to be activated by activin type I receptor-like kinase-2 (ALK-2) which stimulates heteromerization between SMAD9 and SMAD4. ALK-2 binds TGF-beta, activin and BMP., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070411 I-SMAD binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:0030154 cell differentiation;GO:0048863 stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O54835-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V612-1", "uniprot_id": [ { "id": "G3V612_RAT", "url": "https://www.uniprot.org/uniprot/G3V612", "type": "external" } ], "mass": 32451.0, "length": 323, "protein_name": "Oligodendrocyte transcription factor 2", "gene_name": "Olig2", "organism": "Rat", "refseq_name": "oligodendrocyte transcription factor 2", "refseq_ac": [ { "id": "NP_001094027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094027", "type": "external" } ], "gene_names_uniprotkb": "Olig2", "gene_names_refseq": "Olig2", "protein_names_uniprotkb": "Oligodendrocyte transcription factor 2", "protein_names_refseq": "oligodendrocyte lineage transcription factor 2; oligodendrocyte transcription factor 2", "tax_id": 10116, "disease": "status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (rno:304103)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15519240;16641100;22673903;30143582;35301318", "class_list": "", "function": "Increased expression of Olig2 plays a critically important role in the differentiation of adult oligodendrocyte progenitor cells into remyelinating oligodendrocytes., [RefSeq, PubMed]; The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents. Erratum:[Nat Commun. 2022 Jun 1;13(1):3164. PMID: 35650201] Publication Status: Online-Only, [RefSeq, PubMed]; These data strongly suggest that bone marrow stromal cells (BMSCs) can promote the differentiation of Neural stem cells (NSCs) into oligodendrocytes through mediating Id2 and Olig1/2 expression by blocking the BMP/Smad signaling pathway Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0071837 HMG box domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0045665 negative regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "G3V612-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06883-1", "uniprot_id": [ { "id": "GLUC_RAT", "url": "https://www.uniprot.org/uniprot/P06883", "type": "external" } ], "mass": 20846.0, "length": 180, "protein_name": "Pro-glucagon", "gene_name": "Gcg", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gcg", "gene_names_refseq": "", "protein_names_uniprotkb": "Pro-glucagon", "protein_names_refseq": "", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); prediabetes syndrome (Disease Ontology:DOID:11716)", "pathway": " (rno:24952); (R-RNO-163359); (R-RNO-381676); (R-RNO-381771); (R-RNO-416476); (R-RNO-420092); (R-RNO-422085)", "pathway_count": 7, "publication_count": 13, "publication_id_list": "10322410;10605628;11564680;12554744;12626323;14719035;1692320;22673903;3528148;6094539;6548696;7937770;8721980", "class_list": "", "function": "May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life., [UniProtKB, PubMed, PubMed]; Oxyntomodulin significantly reduces food intake., [UniProtKB, PubMed]; Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Binds to and activates the glucagon receptor GCGR, which couples to the G(s) G protein and elevates intracellular cAMP, triggering downstream metabolic responses., [UniProtKB, PubMed, PubMed]; Potent stimulator of glucose-dependent insulin release (Probable). Also stimulates insulin release in response to IL6 (By similarity). Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis (Probable)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031769 glucagon receptor binding;GO:0042802 identical protein binding;GO:0005179 hormone activity;GO:0048018 receptor ligand activity;GO:0031767 gastric inhibitory polypeptide receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:1903576 response to L-arginine;GO:0006109 regulation of carbohydrate metabolic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0043066 negative regulation of apoptotic process;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P06883-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V6S8-1", "uniprot_id": [ { "id": "SRSF6_RAT", "url": "https://www.uniprot.org/uniprot/G3V6S8", "type": "external" } ], "mass": 39025.0, "length": 339, "protein_name": "Serine/arginine-rich splicing factor 6", "gene_name": "Srsf6", "organism": "Rat", "refseq_name": "serine/arginine-rich splicing factor 6", "refseq_ac": [ { "id": "NP_001014207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014207", "type": "external" } ], "gene_names_uniprotkb": "Srsf6; Sfrs6; Srp55", "gene_names_refseq": "Sfrs6; Srsf6", "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 6; Pre-mRNA-splicing factor SRP55; Splicing factor, arginine/serine-rich 6", "protein_names_refseq": "pre-mRNA-splicing factor SRP55; serine/arginine-rich splicing factor 6; splicing factor, arginine/serine-rich 6", "tax_id": 10116, "disease": "spermatogenic failure 3 (Disease Ontology:DOID:0070168); Huntington's disease (Disease Ontology:DOID:12858); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); lung cancer (Disease Ontology:DOID:1324); colon adenocarcinoma (Disease Ontology:DOID:234); skin cancer (Disease Ontology:DOID:4159); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": " (rno:362264)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12549914;22673903;22767602", "class_list": "", "function": "Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5PQM1", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0045617 negative regulation of keratinocyte differentiation;GO:0061041 regulation of wound healing;GO:0010629 negative regulation of gene expression;GO:0032868 response to insulin;GO:0048025 negative regulation of mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "G3V6S8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48974-1", "uniprot_id": [ { "id": "V1BR_RAT", "url": "https://www.uniprot.org/uniprot/P48974", "type": "external" } ], "mass": 47086.0, "length": 425, "protein_name": "Vasopressin V1b receptor", "gene_name": "Avpr1b", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Avpr1b; LOC100909648", "gene_names_refseq": "", "protein_names_uniprotkb": "Vasopressin V1b receptor; AVPR V1b; AVPR V3; Antidiuretic hormone receptor 1b; V1bR; Vasopressin V3 receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); autism spectrum disorder (Disease Ontology:DOID:0060041); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); bipolar disorder (Disease Ontology:DOID:3312); mood disorder (Disease Ontology:DOID:3324); pituitary adenoma (Disease Ontology:DOID:3829); ACTH-secreting pituitary adenoma (Disease Ontology:DOID:7004)", "pathway": " (rno:100909648); (R-RNO-388479); (R-RNO-416476)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "7624319;7626108", "class_list": "", "function": "Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0017046 peptide hormone binding;GO:0005000 vasopressin receptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0042127 regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0008217 regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P48974-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V6U9-1", "uniprot_id": [ { "id": "SETD3_RAT", "url": "https://www.uniprot.org/uniprot/G3V6U9", "type": "external" } ], "mass": 67420.0, "length": 596, "protein_name": "Actin-histidine N-methyltransferase", "gene_name": "Setd3", "organism": "Rat", "refseq_name": "actin-histidine N-methyltransferase", "refseq_ac": [ { "id": "NP_001333399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333399", "type": "external" } ], "gene_names_uniprotkb": "Setd3", "gene_names_refseq": "RGD1309550; Setd3", "protein_names_uniprotkb": "Actin-histidine N-methyltransferase; 2.1.1.85; Protein-L-histidine N-tele-methyltransferase; SET domain-containing protein 3", "protein_names_refseq": "SET domain containing 3, actin histidine methyltransferase; SET domain-containing protein 3; actin-histidine N-methyltransferase; histone-lysine N-methyltransferase setd3-like; histone-lysine N-methyltransferase setd3; protein-L-histidine N-tele-methyltransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:299295); (R-RNO-3214841)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21832073;29950684;30526847;34218417", "class_list": "", "function": "Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (By similarity). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; SETD3 Downregulation Mediates PTEN Upregulation-Induced Ischemic Neuronal Death Through Suppression of Actin Polymerization and Mitochondrial Function., [RefSeq, PubMed]; SETD3 is a H3K4/K36 methyltransferase and plays an important role in the transcriptional regulation of muscle cell differentiation, [RefSeq, PubMed]; SETD3 protein is the actin-specific histidine N-methyltransferase. Publication Status: Online-Only, [RefSeq, PubMed]; The functional interplay between SETD3 and FoxM1 on chromatin may negatively regulate VEGF expression under hypoxic pulmonary hypertension (HPH); through the VEGF receptor-extracellular signal-regulated kinase-hypoxia-induced factor-1 signal pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FWY6", "ec_number_list": [ { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.370", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.370", "type": "external" }, { "id": "2.1.1.371", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.371", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.85", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003779 actin binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0042800 histone H3K4 methyltransferase activity;GO:0046975 histone H3K36 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051149 positive regulation of muscle cell differentiation;GO:0030047 actin modification;GO:0008218 bioluminescence;GO:0070472 regulation of uterine smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "G3V6U9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13053-1", "uniprot_id": [ { "id": "VDR_RAT", "url": "https://www.uniprot.org/uniprot/P13053", "type": "external" } ], "mass": 47814.0, "length": 423, "protein_name": "Vitamin D3 receptor", "gene_name": "Vdr", "organism": "Rat", "refseq_name": "vitamin D3 receptor", "refseq_ac": [ { "id": "NP_058754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058754", "type": "external" } ], "gene_names_uniprotkb": "Vdr; Nr1i1", "gene_names_refseq": "Nr1i1; Vdr", "protein_names_uniprotkb": "Vitamin D3 receptor; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1; VDR", "protein_names_refseq": "1,25-dihydroxyvitamin D3 receptor; nuclear receptor subfamily 1 group I member 1; vitamin D (1,25- dihydroxyvitamin D3) receptor; vitamin D3 receptor", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); erythema nodosum (Disease Ontology:DOID:0080750); vitamin D-dependent rickets (Disease Ontology:DOID:0080883); vitamin D-dependent rickets type 2A (Disease Ontology:DOID:0080884); autosomal recessive limb-girdle muscular dystrophy type 2B (Disease Ontology:DOID:0110276); pigmentation disease (Disease Ontology:DOID:10123); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); rickets (Disease Ontology:DOID:10609); primary hyperparathyroidism (Disease Ontology:DOID:11202); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); gestational diabetes (Disease Ontology:DOID:11714); myopia (Disease Ontology:DOID:11830); otosclerosis (Disease Ontology:DOID:12185); primary biliary cholangitis (Disease Ontology:DOID:12236); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); secondary hyperparathyroidism (Disease Ontology:DOID:12466); Behcet's disease (Disease Ontology:DOID:13241); peptic esophagitis (Disease Ontology:DOID:13976); Parkinson's disease (Disease Ontology:DOID:14330); Fabry disease (Disease Ontology:DOID:14499); breast cancer (Disease Ontology:DOID:1612); aortic valve stenosis (Disease Ontology:DOID:1712); squamous cell carcinoma (Disease Ontology:DOID:1749); melanoma (Disease Ontology:DOID:1909); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); multiple sclerosis (Disease Ontology:DOID:2377); basal cell carcinoma (Disease Ontology:DOID:2513); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); atopic dermatitis (Disease Ontology:DOID:3310); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); Turner syndrome (Disease Ontology:DOID:3491); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); tuberculosis (Disease Ontology:DOID:399); esophagus adenocarcinoma (Disease Ontology:DOID:4914); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); hematopoietic system disease (Disease Ontology:DOID:74); osteoarthritis (Disease Ontology:DOID:8398); retinal degeneration (Disease Ontology:DOID:8466); psoriasis (Disease Ontology:DOID:8893); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); Barrett's esophagus (Disease Ontology:DOID:9206); type 2 diabetes mellitus (Disease Ontology:DOID:9352); cholangitis (Disease Ontology:DOID:9446); steatotic liver disease (Disease Ontology:DOID:9452); alopecia (Disease Ontology:DOID:987)", "pathway": " (rno:24873); (R-RNO-196791); (R-RNO-383280); (R-RNO-4090294)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10866662;15065852;17227670;2829212;2849110;38320454;39094671", "class_list": "", "function": "1,25-D3 ameliorates ischemic brain injury by alleviating endoplasmic reticulum stress and ferroptosis: Involvement of vitamin D receptor and p53 signaling., [RefSeq, PubMed]; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:17227670). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (PubMed:17227670). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (By similarity)., [UniProtKB, UniProtKB, PubMed]; VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 60, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0043235 receptor complex;GO:0048471 perinuclear region of cytoplasm;GO:0016363 nuclear matrix", "go_biological_process": "GO:0070561 vitamin D receptor signaling pathway;GO:0060745 mammary gland branching involved in pregnancy;GO:0038185 nuclear receptor-mediated bile acid signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P13053-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88766-1", "uniprot_id": [ { "id": "MMP8_RAT", "url": "https://www.uniprot.org/uniprot/O88766", "type": "external" } ], "mass": 53277.0, "length": 466, "protein_name": "Neutrophil collagenase", "gene_name": "Mmp8", "organism": "Rat", "refseq_name": "neutrophil collagenase preproprotein", "refseq_ac": [ { "id": "NP_071557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071557", "type": "external" } ], "gene_names_uniprotkb": "Mmp8", "gene_names_refseq": "Mmp8", "protein_names_uniprotkb": "Neutrophil collagenase; 3.4.24.34; MMP-8; Matrix metalloproteinase-8", "protein_names_refseq": "MMP-8; matrix metalloproteinase-8; neutrophil collagenase preproprotein; neutrophil collagenase; neutrophil collagenease", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); thoracic aortic aneurysm (Disease Ontology:DOID:14004); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); carotid artery disease (Disease Ontology:DOID:3407); brain infarction (Disease Ontology:DOID:3454); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (rno:63849); (R-RNO-1442490); (R-RNO-1474228); (R-RNO-1592389); (R-RNO-6798695)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "15052653;33468174;34550870;34830409;36322784", "class_list": "", "function": "A Novel Protective Role for Matrix Metalloproteinase-8 in the Pulmonary Vasculature., [RefSeq, PubMed]; Can degrade fibrillar type I, II, and III collagens., [UniProtKB]; Elevated expression of MMP8 and MMP9 contributes to diabetic osteoarthritis progression in a rat model. Publication Status: Online-Only, [RefSeq, PubMed]; Mesenchymal Stem Cells Promote Wound Healing and Effects on Expression of Matrix Metalloproteinases-8 and 9 in the Wound Tissue of Diabetic Rats., [RefSeq, PubMed]; Osteoblasts and osteocytes in apposed bone degrade extracellular matrix (ECM) molecules with MMPs and regulate the degradation by inhibiting the activity of MMPs using TIMPs., [RefSeq, PubMed]; Trabecular Bone Parameters, TIMP-2, MMP-8, MMP-13, VEGF Expression and Immunolocalization in Bone and Cartilage in Newborn Offspring Prenatally Exposed to Fumonisins. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.4.24.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:1903980 positive regulation of microglial cell activation;GO:0071222 cellular response to lipopolysaccharide;GO:0032760 positive regulation of tumor necrosis factor production", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O88766-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47967-1", "uniprot_id": [ { "id": "LEG5_RAT", "url": "https://www.uniprot.org/uniprot/P47967", "type": "external" } ], "mass": 16196.0, "length": 145, "protein_name": "Galectin-5", "gene_name": "Lgals5", "organism": "Rat", "refseq_name": "galectin-5", "refseq_ac": [ { "id": "NP_037108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037108", "type": "external" } ], "gene_names_uniprotkb": "Lgals5", "gene_names_refseq": "Lgals5", "protein_names_uniprotkb": "Galectin-5; Gal-5; RL-18", "protein_names_refseq": "RL-18; gal-5; galectin-5; lectin, galactose binding, soluble 5", "tax_id": 10116, "disease": "diphthamide deficiency syndrome (Disease Ontology:DOID:0070476); diphthamide deficiency syndrome 2 (Disease Ontology:DOID:0070478)", "pathway": " (rno:25475)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16740401;19903899;34944498;7890611", "class_list": "", "function": "Galectin-5 functionality in the exosomal sorting pathway during rat reticulocyte maturation., [RefSeq, PubMed]; May function in erythrocyte differentiation., [UniProtKB]; Structural Characterization of Rat Galectin-5, an N-Tailed Monomeric Proto-Type-like Galectin. Publication Status: Online-Only, [RefSeq, PubMed]; The presented results on galectin-5 relative to galectin-9 intimate distinct functions especially in erythropoiesis and imply currently unknown mechanisms to compensate its absence from the galectin network in other mammals., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0016936 galactoside binding;GO:0030395 lactose binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0032689 negative regulation of type II interferon production;GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation;GO:0070234 positive regulation of T cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P47967-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23749-1", "uniprot_id": [ { "id": "MRGRF_RAT", "url": "https://www.uniprot.org/uniprot/P23749", "type": "external" } ], "mass": 38364.0, "length": 343, "protein_name": "Mas-related G protein-coupled receptor member F", "gene_name": "Mrgprf", "organism": "Rat", "refseq_name": "mas-related G-protein coupled receptor member F", "refseq_ac": [ { "id": "NP_714944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_714944", "type": "external" } ], "gene_names_uniprotkb": "Mrgprf; Mrgf; Rta", "gene_names_refseq": "MrgF; Mrgprf", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member F; G protein-coupled receptor RTA; Mas-related gene F protein", "protein_names_refseq": "G protein coupled receptor (RTA); G protein coupled receptor Rca; MAS-related G-protein coupled receptor, member F; MAS-related GPR, member F; mas-related G-protein coupled receptor member F; mas-related gene F protein", "tax_id": 10116, "disease": "", "pathway": " (rno:266762)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2109324", "class_list": "", "function": "Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P23749-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70143-1", "uniprot_id": [ { "id": "SHC3_RAT", "url": "https://www.uniprot.org/uniprot/O70143", "type": "external" } ], "mass": 64100.0, "length": 594, "protein_name": "SHC-transforming protein 3", "gene_name": "Shc3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Shc3; Nshc; Shcc", "gene_names_refseq": "", "protein_names_uniprotkb": "SHC-transforming protein 3; N-Shc; Neuronal Shc; SH2 domain protein C3; SHC-transforming protein C; Src homology 2 domain-containing-transforming protein C3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:114858); (R-RNO-167044); (R-RNO-5673001); (R-RNO-8853659)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "9507002", "class_list": "", "function": "Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004713 protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007611 learning or memory;GO:0035556 intracellular signal transduction;GO:0035249 synaptic transmission, glutamatergic", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O70143-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88780-1", "uniprot_id": [ { "id": "KLK8_RAT", "url": "https://www.uniprot.org/uniprot/O88780", "type": "external" } ], "mass": 28510.0, "length": 260, "protein_name": "Kallikrein-8", "gene_name": "Klk8", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Klk8; Bsp1; Nrpn; Prss19", "gene_names_refseq": "", "protein_names_uniprotkb": "Kallikrein-8; 3.4.21.118; Brain serine protease 1; NP; Neuropsin; Serine protease 19", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:308565); (R-RNO-6809371)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9722524", "class_list": "", "function": "Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.118", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.118", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030141 secretory granule;GO:0097180 serine protease inhibitor complex", "go_biological_process": "GO:0006508 proteolysis;GO:0007613 memory;GO:0050808 synapse organization;GO:0048812 neuron projection morphogenesis;GO:0009611 response to wounding", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O88780-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50343-1", "uniprot_id": [ { "id": "TRYB2_RAT", "url": "https://www.uniprot.org/uniprot/P50343", "type": "external" } ], "mass": 30508.0, "length": 274, "protein_name": "Tryptase beta-2", "gene_name": "Tpsb2", "organism": "Rat", "refseq_name": "tryptase beta-2 precursor", "refseq_ac": [ { "id": "NP_062053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062053", "type": "external" } ], "gene_names_uniprotkb": "Tpsb2; Mcp6; Mcpt6", "gene_names_refseq": "Mcpt6; Tpsb2", "protein_names_uniprotkb": "Tryptase beta-2; 3.4.21.59; Mast cell protease 6; Tryptase-2; rMCP-6", "protein_names_refseq": "mast cell protease 6; rMCP-6; tryptase beta-2 precursor; tryptase-2", "tax_id": 10116, "disease": "carcinoma (Disease Ontology:DOID:305); pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (rno:29268); (R-RNO-1592389)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "8537314;8996238", "class_list": "", "function": "Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Plays a role in innate immunity., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P97593", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.4.21.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "3.4.21.39", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.39", "type": "external" }, { "id": "3.4.21.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.59", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008201 heparin binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:1905368 peptidase complex", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P50343-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48965-1", "uniprot_id": [ { "id": "MPIP1_RAT", "url": "https://www.uniprot.org/uniprot/P48965", "type": "external" } ], "mass": 59218.0, "length": 525, "protein_name": "M-phase inducer phosphatase 1", "gene_name": "Cdc25a", "organism": "Rat", "refseq_name": "M-phase inducer phosphatase 1", "refseq_ac": [ { "id": "NP_598255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598255", "type": "external" } ], "gene_names_uniprotkb": "Cdc25a", "gene_names_refseq": "Cdc25a", "protein_names_uniprotkb": "M-phase inducer phosphatase 1; 3.1.3.48; Dual specificity phosphatase Cdc25A", "protein_names_refseq": "M-phase inducer phosphatase 1; dual specificity phosphatase Cdc25A", "tax_id": 10116, "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); vulva squamous cell carcinoma (Disease Ontology:DOID:2101); breast carcinoma (Disease Ontology:DOID:3459); cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (rno:171102); (R-RNO-176187); (R-RNO-5689880); (R-RNO-69200); (R-RNO-69202); (R-RNO-69273); (R-RNO-69601); (R-RNO-69656)", "pathway_count": 8, "publication_count": 6, "publication_id_list": "10373478;14742443;22155366;24211536;39305937;8156993", "class_list": "", "function": "Accelerated cholangiocyte cystogenesis is likely due to overexpression of Cdc25A, [RefSeq, PubMed]; Cdc25A inhibitors block cell-cycle progression and proliferation, reduce liver and kidney weights and cyst growth in animal models of polycystic kidney/liver disease., [RefSeq, PubMed]; Cdc25A phosphatase is activated and mediates neuronal cell death by PUMA via pRb/E2F1 pathway in a model of Parkinson's disease., [RefSeq, PubMed]; Endothelin increases expression and activity of CDC25A, the regulatory phosphatase responsible for dephosphorylating Tyr(15)., [RefSeq, PubMed]; Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:10373478). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:10373478). Also dephosphorylates CDK2 in complex with cyclin-E, in vitro (By similarity)., [UniProtKB, UniProtKB, PubMed]; Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.4.26.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.26.1", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" } ], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051087 protein-folding chaperone binding;GO:0004721 phosphoprotein phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0000082 G1/S transition of mitotic cell cycle;GO:0009314 response to radiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P48965-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V8T1-1", "uniprot_id": [ { "id": "MPP8_RAT", "url": "https://www.uniprot.org/uniprot/G3V8T1", "type": "external" } ], "mass": 96784.0, "length": 851, "protein_name": "M-phase phosphoprotein 8", "gene_name": "Mphosph8; Parp4", "organism": "Rat", "refseq_name": "M-phase phosphoprotein 8", "refseq_ac": [ { "id": "NP_001017375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017375", "type": "external" } ], "gene_names_uniprotkb": "Mphosph8; Parp4; Mphosph8; Mpp8", "gene_names_refseq": "AABR07018038.3; Ab2-008; Mphosph8; RGD1305133", "protein_names_uniprotkb": "M-phase phosphoprotein 8", "protein_names_refseq": "M-phase phosphoprotein 8; M-phase phosphoprotein, mpp8", "tax_id": 10116, "disease": "", "pathway": " (rno:290270); (R-RNO-9764725); (R-RNO-9843970)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "25660450;29393594", "class_list": "", "function": "Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression. As part of the HUSH complex, promotes epigenetic repression of mobile genetic elements, such as retroviruses and transposable elements: the HUSH complex mainly represses LINE-1 (L1) retrotransposons that are still capable of transposition. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. MPHOSPH8 mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2, a chromatin remodeler that compacts chromatin. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. As part of the HUSH2 complex, promotes epigenetic repression of interferon-stimulated genes. Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates silencing of E-cadherin (CDH1) and protocadherin genes in the nervous system., [UniProtKB, UniProtKB]; Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins., [UniProtKB, UniProtKB]; These results indicate that MPP8 could have a role for silencing genes that are associated with differentiation of the testis and the mesoderm by interacting with epigenetic repressors modules such as the PRC1 complex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KLM1", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0062072 histone H3K9me2/3 reader activity;GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0019899 enzyme binding;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0000792 heterochromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045814 negative regulation of gene expression, epigenetic;GO:0032480 negative regulation of type I interferon production;GO:0044027 negative regulation of gene expression via chromosomal CpG island methylation;GO:0140719 constitutive heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "G3V8T1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54766-1", "uniprot_id": [ { "id": "ZP1_RAT", "url": "https://www.uniprot.org/uniprot/O54766", "type": "external" } ], "mass": 67853.0, "length": 617, "protein_name": "Zona pellucida sperm-binding protein 1", "gene_name": "Zp1", "organism": "Rat", "refseq_name": "zona pellucida sperm-binding protein 1 precursor", "refseq_ac": [ { "id": "NP_445961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445961", "type": "external" } ], "gene_names_uniprotkb": "Zp1", "gene_names_refseq": "ZP1-202; Zp1", "protein_names_uniprotkb": "Zona pellucida sperm-binding protein 1; Zona pellucida glycoprotein 1; Zp-1", "protein_names_refseq": "zona pellucida glycoprotein 1 (sperm receptor); zona pellucida sperm-binding protein 1 precursor; zona pellucida sperm-binding protein 1; zp-1", "tax_id": 10116, "disease": "", "pathway": " (rno:85271)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16342937;33624742;9820205", "class_list": "", "function": "Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida., [UniProtKB, UniProtKB, UniProtKB]; Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the zona pellucida, resulting in zona absence and female infertility in ratsdagger., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035804 structural constituent of egg coat;GO:0032190 acrosin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0035805 egg coat", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0060468 prevention of polyspermy;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O54766-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33671-1", "uniprot_id": [ { "id": "SDC3_RAT", "url": "https://www.uniprot.org/uniprot/P33671", "type": "external" } ], "mass": 45919.0, "length": 442, "protein_name": "Syndecan-3", "gene_name": "Sdc3", "organism": "Rat", "refseq_name": "syndecan-3 precursor", "refseq_ac": [ { "id": "NP_446345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446345", "type": "external" } ], "gene_names_uniprotkb": "Sdc3; Synd3", "gene_names_refseq": "Sdc3", "protein_names_uniprotkb": "Syndecan-3; N-syndecan; Neuroglycan; SYND3", "protein_names_refseq": "N-syndecan; SYND3; neuroglycan; syndecan-3 precursor", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:116673); (R-RNO-1971475); (R-RNO-2022928); (R-RNO-2024096); (R-RNO-3000170); (R-RNO-975634); (R-RNO-9769739)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "1556152;24498267;33170350;8175719;9006931;9089390;9817766", "class_list": "", "function": "Cell surface proteoglycan that may bear heparan sulfate. May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism (By similarity)., [UniProtKB]; Cell surface proteoglycan., [UniProtKB, UniProtKB]; Data suggest that Y-P30 can control the nuclear localization of Calcium/calmodulin-dependent serine kinase (CASK) in a syndecan (SDC) -2 and -3 -dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]; Syndecan-3 contributes to the regulation of the microenvironment at the node of Ranvier following end-toside neurorrhaphy: sodium image analysis., [RefSeq, PubMed]", "predicted_glycosites": 15, "predicted_n_glycosites": 0, "predicted_o_glycosites": 15, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "P97614", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0044393 microspike;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P33671-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15589-1", "uniprot_id": [ { "id": "STS_RAT", "url": "https://www.uniprot.org/uniprot/P15589", "type": "external" } ], "mass": 62679.0, "length": 577, "protein_name": "Steryl-sulfatase", "gene_name": "Sts", "organism": "Rat", "refseq_name": "steryl-sulfatase precursor", "refseq_ac": [ { "id": "NP_036793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036793", "type": "external" } ], "gene_names_uniprotkb": "Sts", "gene_names_refseq": "Sts", "protein_names_uniprotkb": "Steryl-sulfatase; 3.1.6.2; ASC; Arylsulfatase C; Steroid sulfatase; Steryl-sulfate sulfohydrolase", "protein_names_refseq": "ASC; arylsulfatase C; steroid sulfatase (microsomal), isozyme S; steryl-sulfatase precursor; steryl-sulfatase; steryl-sulfate sulfohydrolase", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); cryptorchidism (Disease Ontology:DOID:11383); X-linked ichthyosis (Disease Ontology:DOID:1700)", "pathway": " (rno:24800); (R-RNO-1663150); (R-RNO-196071); (R-RNO-9840310)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "2765556", "class_list": "", "function": "Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.7", "type": "external" }, { "id": "3.1.6.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.2", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.1.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.1", "type": "external" }, { "id": "3.1.6.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.18", "type": "external" }, { "id": "3.1.6.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.-", "type": "external" }, { "id": "3.1.6.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.15", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004065 arylsulfatase activity;GO:0008484 sulfuric ester hydrolase activity;GO:0004773 steryl-sulfatase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007611 learning or memory;GO:0008284 positive regulation of cell population proliferation;GO:0007565 female pregnancy;GO:0009268 response to pH;GO:0043588 skin development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P15589-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35251-1", "uniprot_id": [ { "id": "VEGFD_RAT", "url": "https://www.uniprot.org/uniprot/O35251", "type": "external" } ], "mass": 37113.0, "length": 326, "protein_name": "Vascular endothelial growth factor D", "gene_name": "Vegfd", "organism": "Rat", "refseq_name": "vascular endothelial growth factor D precursor", "refseq_ac": [ { "id": "NP_113949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113949", "type": "external" } ], "gene_names_uniprotkb": "Vegfd; Figf", "gene_names_refseq": "Figf; Vegf-d; Vegfd", "protein_names_uniprotkb": "Vascular endothelial growth factor D; FIGF; VEGF-D; c-Fos-induced growth factor", "protein_names_refseq": "c-fos-induced growth factor; vascular endothelial growth factor D precursor", "tax_id": 10116, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); ovarian carcinoma (Disease Ontology:DOID:4001); pancreatic intraductal papillary-mucinous neoplasm (Disease Ontology:DOID:7575)", "pathway": " (rno:360457); (R-RNO-114608); (R-RNO-194313); (R-RNO-195399)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11683876;22818386", "class_list": "", "function": "Expression of VEGF-D and its receptor, VEGFR-3, are enhanced in various cell types in the infarcted heart., [RefSeq, PubMed]; Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-3 (Flt4) receptor (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q91ZE4", "ec_number_list": [], "go_molecular_function": "GO:0043185 vascular endothelial growth factor receptor 3 binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0008083 growth factor activity;GO:0005172 vascular endothelial growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0008283 cell population proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0001666 response to hypoxia;GO:0032755 positive regulation of interleukin-6 production;GO:0045766 positive regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35251-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26434-1", "uniprot_id": [ { "id": "SL9A4_RAT", "url": "https://www.uniprot.org/uniprot/P26434", "type": "external" } ], "mass": 81522.0, "length": 717, "protein_name": "Sodium/hydrogen exchanger 4", "gene_name": "Slc9a4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc9a4; Nhe4", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium/hydrogen exchanger 4; NHE-4; Na(+)/H(+) exchanger 4; Solute carrier family 9 member 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); major depressive disorder (Disease Ontology:DOID:1470); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); cocaine abuse (Disease Ontology:DOID:809); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24785); (R-RNO-425986)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11553518;12576672;1577762;16158325;7961960;8944646;9038815;9374634;9610358;9691122;9755122", "class_list": "", "function": "Electroneutral antiporter that exchanges sodium for protons or ammonium ions at the basolateral membrane of epithelia to regulate cell volume and intracellular pH upon hypertonic conditions (PubMed:7961960, PubMed:8944646, PubMed:9038815). As part of transcellular ammonia transport in renal tubules, mediates basolateral ammonium extrusion in the medullary thick ascending limb, regulating the corticopapillary ammonium gradient and overall renal acid excretion (By similarity). Mediates sodium:proton exchange in gastric parietal cells secondary to cAMP-dependent acid secretion and hyperosmolarity. Possibly coupled to chloride:bicarbonate antiporter, enables loading of parietal cells with sodium and chloride ions to maintain cell volume and normal gastric acid secretion (By similarity). Functions as a sodium sensor in neurons of organum vasculosum of the lamina terminalis where it regulates water intake in response to increased sodium concentration in body fluids (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015386 potassium:proton antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0042589 zymogen granule membrane", "go_biological_process": "GO:0070634 transepithelial ammonium transport;GO:0001696 gastric acid secretion;GO:0051453 regulation of intracellular pH;GO:0071805 potassium ion transmembrane transport;GO:0002064 epithelial cell development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P26434-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00539-1", "uniprot_id": [ { "id": "MOS_RAT", "url": "https://www.uniprot.org/uniprot/P00539", "type": "external" } ], "mass": 37621.0, "length": 339, "protein_name": "Proto-oncogene serine/threonine-protein kinase mos", "gene_name": "Mos", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mos", "gene_names_refseq": "", "protein_names_uniprotkb": "Proto-oncogene serine/threonine-protein kinase mos; 2.7.11.1; Oocyte maturation factor mos; Proto-oncogene c-Mos", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:24559)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1697408;6322135", "class_list": "", "function": "Serine/threonine kinase involved in the regulation of MAPK signaling. Is an activator of the ERK1/2 signaling cascade playing an essential role in the stimulation of oocyte maturation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004709 MAP kinase kinase kinase activity;GO:0043426 MRF binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0007283 spermatogenesis;GO:0035556 intracellular signal transduction;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P00539-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54767-1", "uniprot_id": [ { "id": "ZP2_RAT", "url": "https://www.uniprot.org/uniprot/O54767", "type": "external" } ], "mass": 78444.0, "length": 695, "protein_name": "Zona pellucida sperm-binding protein 2", "gene_name": "Zp2", "organism": "Rat", "refseq_name": "zona pellucida sperm-binding protein 2 precursor", "refseq_ac": [ { "id": "NP_112412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112412", "type": "external" } ], "gene_names_uniprotkb": "Zp2; Zpa", "gene_names_refseq": "Zp-2; Zp2", "protein_names_uniprotkb": "Zona pellucida sperm-binding protein 2; Zona pellucida glycoprotein 2; Zona pellucida protein A; Zp-2", "protein_names_refseq": "zona pellucida 2 glycoprotein; zona pellucida glycoprotein 2 (sperm receptor); zona pellucida glycoprotein ZP2; zona pellucida protein A; zona pellucida sperm-binding protein 2 precursor; zona pellucida sperm-binding protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:81828)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16342937;9820205", "class_list": "", "function": "Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035804 structural constituent of egg coat;GO:0032190 acrosin binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0005771 multivesicular body;GO:0016234 inclusion body", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0002455 humoral immune response mediated by circulating immunoglobulin;GO:0060468 prevention of polyspermy;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O54767-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23811-1", "uniprot_id": [ { "id": "SCTR_RAT", "url": "https://www.uniprot.org/uniprot/P23811", "type": "external" } ], "mass": 51234.0, "length": 449, "protein_name": "Secretin receptor", "gene_name": "Sctr", "organism": "Rat", "refseq_name": "secretin receptor precursor", "refseq_ac": [ { "id": "NP_112377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112377", "type": "external" } ], "gene_names_uniprotkb": "Sctr", "gene_names_refseq": "Sctr", "protein_names_uniprotkb": "Secretin receptor; SCT-R", "protein_names_refseq": "SCT-R; secretin receptor precursor", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:81779); (R-RNO-420092)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12403838;15276242;1646711;22692904;25332973;27330080;29393594;7476911;9506976", "class_list": "", "function": "G protein-coupled receptor activated by secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:12403838, PubMed:25332973). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and activates cAMP-dependent pathway (PubMed:12403838, PubMed:9506976). Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]; Secretin receptors are overexpressed in various endocrine tumor cells and play a proproliferative role in pheochromocytoma and adrenocortical carcinoma cells., [RefSeq, PubMed]; Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors., [RefSeq, PubMed]; This recepetor interacts with secretin at specific binding sites., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0042277 peptide binding;GO:0015055 secretin receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0032098 regulation of appetite", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P23811-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08775-1", "uniprot_id": [ { "id": "VGFR2_RAT", "url": "https://www.uniprot.org/uniprot/O08775", "type": "external" } ], "mass": 150394.0, "length": 1343, "protein_name": "Vascular endothelial growth factor receptor 2", "gene_name": "Kdr", "organism": "Rat", "refseq_name": "vascular endothelial growth factor receptor 2 precursor", "refseq_ac": [ { "id": "NP_037194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037194", "type": "external" } ], "gene_names_uniprotkb": "Kdr; Flk1", "gene_names_refseq": "Kdr; Vegfr-2", "protein_names_uniprotkb": "Vascular endothelial growth factor receptor 2; 2.7.10.1; FLK-1; Fetal liver kinase 1; Protein-tyrosine kinase receptor flk-1; VEGFR-2", "protein_names_refseq": "FLK-1; FLK1 kinase insert domain receptor (VEGF receptor 2); FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2); fetal liver kinase 1; kinase insert domain protein receptor; protein-tyrosine kinase receptor flk-1; vascular endothelial growth factor receptor 2 precursor; vascular endothelial growth factor receptor 2", "tax_id": 10116, "disease": "pterygium (Disease Ontology:DOID:0002116); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); salivary gland carcinoma (Disease Ontology:DOID:0050904); stroke (Disease Ontology:DOID:0051061); brain glioma (Disease Ontology:DOID:0060108); colitis (Disease Ontology:DOID:0060180); cerebral cavernous malformation (Disease Ontology:DOID:0060669); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); sarcoma (Disease Ontology:DOID:1115); retinopathy of prematurity (Disease Ontology:DOID:13025); adhesions of uterus (Disease Ontology:DOID:13812); lymphangioma (Disease Ontology:DOID:1475); limited scleroderma (Disease Ontology:DOID:1577); diffuse scleroderma (Disease Ontology:DOID:1580); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); melanoma (Disease Ontology:DOID:1909); brain ischemia (Disease Ontology:DOID:2316); arteriosclerosis (Disease Ontology:DOID:2349); prostate adenocarcinoma (Disease Ontology:DOID:2526); hemangiopericytoma (Disease Ontology:DOID:264); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); allergic contact dermatitis (Disease Ontology:DOID:3042); carcinoma (Disease Ontology:DOID:305); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); inverted papilloma (Disease Ontology:DOID:3179); neurilemmoma (Disease Ontology:DOID:3192); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); thyroid gland carcinoma (Disease Ontology:DOID:3963); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); macular retinal edema (Disease Ontology:DOID:4449); breast angiosarcoma (Disease Ontology:DOID:4511); pancreatic carcinoma (Disease Ontology:DOID:4905); esophagus adenocarcinoma (Disease Ontology:DOID:4914); liver cirrhosis (Disease Ontology:DOID:5082); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); myocardial infarction (Disease Ontology:DOID:5844); nephrolithiasis (Disease Ontology:DOID:585); uveal melanoma (Disease Ontology:DOID:6039); hepatocellular carcinoma (Disease Ontology:DOID:684); retinal telangiectasia (Disease Ontology:DOID:7736); ulcerative colitis (Disease Ontology:DOID:8577); decubitus ulcer (Disease Ontology:DOID:8717); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25589); (R-RNO-194306); (R-RNO-195399); (R-RNO-4420097); (R-RNO-5218921)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "10878616;22673903;33671638;33904385;34169992", "class_list": "", "function": "Disabling VEGF-Response of Purkinje Cells by Downregulation of KDR via miRNA-204-5p. Publication Status: Online-Only, [RefSeq, PubMed]; Effects of Cerebral Ischemia on Levels of Vascular Endothelial Growth Factor (VEGF) and Its Soluble Receptors: A Possible Link to Angiogenesis in Arteriovenous Malformations., [RefSeq, PubMed]; Effects of silencing epididymal vascular endothelial growth factor (VEGF) expression on hyaluronidase (HYD) activity in arsenic poisoning rats through downregulating VEGF receptor 2 (VEGFR2)., [RefSeq, PubMed]; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC (By similarity)., [UniProtKB]", "predicted_glycosites": 17, "predicted_n_glycosites": 16, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 63, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005178 integrin binding;GO:0005524 ATP binding;GO:0015026 coreceptor activity;GO:0019838 growth factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:1901532 regulation of hematopoietic progenitor cell differentiation;GO:1903010 regulation of bone development;GO:0035162 embryonic hemopoiesis;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O08775-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08836-1", "uniprot_id": [ { "id": "IGBP1_RAT", "url": "https://www.uniprot.org/uniprot/O08836", "type": "external" } ], "mass": 39135.0, "length": 340, "protein_name": "Immunoglobulin-binding protein 1", "gene_name": "Igbp1", "organism": "Rat", "refseq_name": "immunoglobulin-binding protein 1", "refseq_ac": [ { "id": "NP_113812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113812", "type": "external" } ], "gene_names_uniprotkb": "Igbp1", "gene_names_refseq": "Igbp1", "protein_names_uniprotkb": "Immunoglobulin-binding protein 1; Alpha4 phosphoprotein; CD79a-binding protein 1; Protein phosphatase 2/4/6 regulatory subunit", "protein_names_refseq": "CD79a-binding protein 1; alpha4 phosphoprotein; immunoglobulin (CD79A) binding protein 1; immunoglobulin-binding protein 1; protein phosphatase 2/4/6 regulatory subunit", "tax_id": 10116, "disease": "corpus callosum agenesis-intellectual disability-coloboma-micrognathia syndrome (Disease Ontology:DOID:0060816)", "pathway": " (rno:58845)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16052526;28526910;29393594;33737606;9296381", "class_list": "", "function": "Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits (By similarity)., [UniProtKB]; Regulation of cardiomyocyte DNA damage and cell death by the type 2A protein phosphatase regulatory protein alpha4. Publication Status: Online-Only, [RefSeq, PubMed]; Report the significance and altered activity of the type 2A protein phosphatase-alpha4 complex in healthy and hypertrophied myocardium., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0031434 mitogen-activated protein kinase kinase binding;GO:0019888 protein phosphatase regulator activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0035303 regulation of dephosphorylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0034612 response to tumor necrosis factor;GO:0035556 intracellular signal transduction;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O08836-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08954-1", "uniprot_id": [ { "id": "SNAI2_RAT", "url": "https://www.uniprot.org/uniprot/O08954", "type": "external" } ], "mass": 29936.0, "length": 268, "protein_name": "Zinc finger protein SNAI2", "gene_name": "Snai2", "organism": "Rat", "refseq_name": "zinc finger protein SNAI2", "refseq_ac": [ { "id": "NP_037167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037167", "type": "external" } ], "gene_names_uniprotkb": "Snai2; Slugh; Slug", "gene_names_refseq": "Slug; Snai2", "protein_names_uniprotkb": "Zinc finger protein SNAI2; Neural crest transcription factor Slug; Protein snail homolog 2", "protein_names_refseq": "Slug, chicken homolog; neural crest transcription factor Slug; protein snail homolog 2; snail family zinc finger 2; zinc finger protein SNAI2", "tax_id": 10116, "disease": "spermatogenic failure 77 (Disease Ontology:DOID:0070576); male infertility (Disease Ontology:DOID:12336); Williams-Beuren syndrome (Disease Ontology:DOID:1928); carcinoma (Disease Ontology:DOID:305); piebaldism (Disease Ontology:DOID:3263); Waardenburg syndrome (Disease Ontology:DOID:9258)", "pathway": " (rno:25554)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16924233;26246400;28488774;9182671", "class_list": "", "function": "S100beta-positive cells express Slug and that its expression is important for subsequent migration and proliferation., [RefSeq, PubMed]; SNAI2 overexpression significantly increased FSCN1 expression at both mRNA and protein level. FSCN1 overexpression reduced the expression of E-cadherin and Claudin 1, but increased the expression of Vimentin and N-cadherin in SCC9 and SCC-15 cells. It is inferred that FSCN1 is a downstream effector of SNAI2 in promoting EMT in HNSC cells., [RefSeq, PubMed]; Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R482", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0060429 epithelium development;GO:0010957 negative regulation of vitamin D biosynthetic process;GO:0070563 negative regulation of vitamin D receptor signaling pathway;GO:2000647 negative regulation of stem cell proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O08954-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35750-1", "uniprot_id": [ { "id": "SHOX2_RAT", "url": "https://www.uniprot.org/uniprot/O35750", "type": "external" } ], "mass": 26221.0, "length": 237, "protein_name": "Short stature homeobox protein 2", "gene_name": "Shox2", "organism": "Rat", "refseq_name": "short stature homeobox protein 2", "refseq_ac": [ { "id": "NP_037160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037160", "type": "external" } ], "gene_names_uniprotkb": "Shox2; Prx3", "gene_names_refseq": "Shox2", "protein_names_uniprotkb": "Short stature homeobox protein 2; Paired family homeodomain protein Prx3", "protein_names_refseq": "paired family homeodomain protein Prx3; short stature homeobox 2; short stature homeobox protein 2", "tax_id": 10116, "disease": "Leri-Weill dyschondrosteosis (Disease Ontology:DOID:0060847); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (rno:25546)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26697824;9371788", "class_list": "", "function": "Important role in the process of intervertebral disc degeneration, [RefSeq, PubMed]; May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35749;O35751", "ec_number_list": [], "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0003170 heart valve development;GO:0060931 sinoatrial node cell development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35750-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35876-1", "uniprot_id": [ { "id": "SMN_RAT", "url": "https://www.uniprot.org/uniprot/O35876", "type": "external" } ], "mass": 31193.0, "length": 289, "protein_name": "Survival motor neuron protein", "gene_name": "Smn1", "organism": "Rat", "refseq_name": "survival motor neuron protein", "refseq_ac": [ { "id": "NP_071954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071954", "type": "external" } ], "gene_names_uniprotkb": "Smn1; Smn", "gene_names_refseq": "Smn1; Smn", "protein_names_uniprotkb": "Survival motor neuron protein", "protein_names_refseq": "survival motor neuron 1; survival motor neuron protein", "tax_id": 10116, "disease": "adult spinal muscular atrophy (Disease Ontology:DOID:0050529); intermediate spinal muscular atrophy (Disease Ontology:DOID:0050530); childhood spinal muscular atrophy (Disease Ontology:DOID:0060160); juvenile spinal muscular atrophy (Disease Ontology:DOID:12376); spinal muscular atrophy (Disease Ontology:DOID:12377); Werdnig-Hoffmann disease (Disease Ontology:DOID:13137)", "pathway": " (rno:64301); (R-RNO-191859)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21389246;22673903;25055867;27153795;29902268;9302277;9758161", "class_list": "", "function": "-SMN and FL-SMN are needed for neuronal polarization and organization of axonal and dendritic compartments, processes that are fundamental for neuronal function and survival Publication Status: Online-Only, [RefSeq, PubMed]; Reduced SMN protein level alters miRNA expression and distribution in neurons., [RefSeq, PubMed]; Report decreased number of motor neurons and a decrease of SMN1 protein expression in spinal cords of rats exposed to uranyl nitrate., [RefSeq, PubMed]; The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55045", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0007409 axonogenesis;GO:0007268 chemical synaptic transmission;GO:0010975 regulation of neuron projection development;GO:0000387 spliceosomal snRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35876-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35910-1", "uniprot_id": [ { "id": "MOT4_RAT", "url": "https://www.uniprot.org/uniprot/O35910", "type": "external" } ], "mass": 50549.0, "length": 471, "protein_name": "Monocarboxylate transporter 4", "gene_name": "Slc16a3", "organism": "Rat", "refseq_name": "monocarboxylate transporter 4", "refseq_ac": [ { "id": "NP_110461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110461", "type": "external" } ], "gene_names_uniprotkb": "Slc16a3; Mct3; Mct4", "gene_names_refseq": "MCT4; Mct3; Slc16a3", "protein_names_uniprotkb": "Monocarboxylate transporter 4; MCT 3; MCT 4; Monocarboxylate transporter 3; Solute carrier family 16 member 3", "protein_names_refseq": "monocarboxylate transporter 3; monocarboxylate transporter 4; solute carrier family 16 (monocarboxylate transporter), member 3; solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (monocarboxylic acid transporter 4)", "tax_id": 10116, "disease": "", "pathway": " (rno:80878); (R-RNO-210991); (R-RNO-433692)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10926847;22673903;26996590;29249221;31578706;33625690;9632638", "class_list": "", "function": "Decreased expression of MCT1/4 in distal airway epithelium may disrupt lung branching morphogenesis and thus contribute to the development of pulmonary hypoplasia in the nitrofen-induced congenital diaphragmatic hernia model., [RefSeq, PubMed]; Inhibition of Hypothalamic MCT4 and MCT1-MCT4 Expressions Affects Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide Expressions., [RefSeq, PubMed]; Proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate (By similarity) (PubMed:10926847, PubMed:9632638). Plays a predominant role in the L-lactate efflux from highly glycolytic cells (PubMed:10926847, PubMed:9632638)., [UniProtKB, PubMed, PubMed, UniProtKB]; The MCT4 membrane expression varied with estrous cycle stage with expression significantly lower than males. MCT4 membrane expression in OVX females was also lower than males, suggesting that androgens play a role in membrane expression of MCT4., [RefSeq, PubMed]; The effects of different training modalities on monocarboxylate transporters MCT1 and MCT4, hypoxia inducible factor-1alpha (HIF-1alpha), and PGC-1alpha gene expression in rat skeletal muscles., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050833 pyruvate transmembrane transporter activity;GO:0015129 lactate transmembrane transporter activity;GO:0015650 lactate:proton symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0035873 lactate transmembrane transport;GO:1901475 pyruvate transmembrane transport;GO:0035879 plasma membrane lactate transport;GO:0042867 pyruvate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35910-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54699-1", "uniprot_id": [ { "id": "S29A2_RAT", "url": "https://www.uniprot.org/uniprot/O54699", "type": "external" } ], "mass": 50265.0, "length": 456, "protein_name": "Equilibrative nucleoside transporter 2", "gene_name": "Slc29a2", "organism": "Rat", "refseq_name": "equilibrative nucleoside transporter 2", "refseq_ac": [ { "id": "NP_113926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113926", "type": "external" } ], "gene_names_uniprotkb": "Slc29a2; Ent2", "gene_names_refseq": "Slc29a2; rENT2", "protein_names_uniprotkb": "Equilibrative nucleoside transporter 2; Equilibrative NBMPR-insensitive nucleoside transporter; Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter; Nucleoside transporter, ei-type; Solute carrier family 29 member 2; rENT2", "protein_names_refseq": "equilibrative NBMPR-insensitive nucleoside transporter; equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter; equilibrative nucleoside transporter 2; nucleoside transporter, ei-type; solute carrier family 29 (equilibrative nucleoside transporter), member 2; solute carrier family 29 (nucleoside transporters), member 2", "tax_id": 10116, "disease": "", "pathway": " (rno:65194); (R-RNO-83936); (R-RNO-9748787)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "18048066;23639800;28209435;28322028;9353301", "class_list": "", "function": "Bidirectional uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:18048066, PubMed:9353301). Functions as a Na(+)-independent, passive transporter (By similarity). Involved in the transport of nucleosides such as inosine, adenosine, uridine, thymidine, cytidine and guanosine (PubMed:9353301). Also mediates nicotinamide uptake supporting homeostasis and modulating its biological activities (By similarity). Can also transport urate (By similarity). Also able to transport purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:18048066). Involved in nucleoside transport at basolateral membrane of kidney cells, allowing liver absorption of nucleoside metabolites (By similarity). Mediates apical nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier (PubMed:23639800). Mediates both the influx and efflux of hypoxanthine in skeletal muscle microvascular endothelial cells to control the amount of intracellular hypoxanthine available for xanthine oxidase-mediated ROS production (PubMed:18048066)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; The ENT2 appears to be the mediator of fluorouracil transport in rat placental trophoblast cells., [RefSeq, PubMed]; The purpose of this study is to determine the localization of nucleoside transporters expressed within rat epididymis to demonstrate the potential of epididymal reabsorption. Using immunohistochemistry, we determined that equilibrative nucleoside transporter 1 (ENT1) is localized to the basolateral membrane of epithelial cells, ENT2 is expressed in the nucleus of the epithelium and CNT2 is expressed by basal cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015205 nucleobase transmembrane transporter activity;GO:0015212 cytidine transmembrane transporter activity;GO:0015213 uridine transmembrane transporter activity;GO:0015211 purine nucleoside transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0015851 nucleobase transport;GO:0015861 cytidine transport;GO:0015858 nucleoside transport;GO:0015860 purine nucleoside transmembrane transport;GO:0015862 uridine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O54699-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70142-1", "uniprot_id": [ { "id": "SHC2_RAT", "url": "https://www.uniprot.org/uniprot/O70142", "type": "external" } ], "mass": 61770.0, "length": 573, "protein_name": "SHC-transforming protein 2", "gene_name": "Shc2", "organism": "Rat", "refseq_name": "SHC-transforming protein 2", "refseq_ac": [ { "id": "NP_001101535", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101535", "type": "external" } ], "gene_names_uniprotkb": "Shc2; Sck", "gene_names_refseq": "Shc2", "protein_names_uniprotkb": "SHC-transforming protein 2; Protein Sck; SH2 domain protein C2; Src homology 2 domain-containing-transforming protein C2", "protein_names_refseq": "SH2 domain protein C2; SHC (Src homology 2 domain containing) transforming protein 2; SHC-transforming protein 2; protein Sck; src homology 2 domain-containing transforming protein C2", "tax_id": 10116, "disease": "", "pathway": " (rno:314612); (R-RNO-167044); (R-RNO-4420097); (R-RNO-5673001)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "12882334;9507002", "class_list": "", "function": "Data show that the regulation of Shc mRNAs in senescence is region as well as isoform specific, [RefSeq, PubMed]; Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O70142-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70461-1", "uniprot_id": [ { "id": "MOT3_RAT", "url": "https://www.uniprot.org/uniprot/O70461", "type": "external" } ], "mass": 51283.0, "length": 490, "protein_name": "Monocarboxylate transporter 3", "gene_name": "Slc16a8", "organism": "Rat", "refseq_name": "monocarboxylate transporter 3", "refseq_ac": [ { "id": "NP_113932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113932", "type": "external" } ], "gene_names_uniprotkb": "Slc16a8; Mct3", "gene_names_refseq": "Mct3; Slc16a8", "protein_names_uniprotkb": "Monocarboxylate transporter 3; MCT 3; Solute carrier family 16 member 8", "protein_names_refseq": "monocarboxylate transporter 3; solute carrier family 16 (monocarboxylate transporter), member 8; solute carrier family 16 (monocarboxylic acid transporters), member 8; solute carrier family 16, member 8 (monocarboxylic acid transporter 3)", "tax_id": 10116, "disease": "", "pathway": " (rno:65200); (R-RNO-210991); (R-RNO-433692)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "9841555", "class_list": "", "function": "Probable retinal pigment epithelium (RPE)-specific proton-coupled L-lactate transporter (By similarity). May facilitate transport of lactate and H(+) out of the retina and could therefore play a role in pH and ion homeostasis of the outer retina (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V7K8", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity;GO:0015355 secondary active monocarboxylate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O70461-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88269-1", "uniprot_id": [ { "id": "MRP6_RAT", "url": "https://www.uniprot.org/uniprot/O88269", "type": "external" } ], "mass": 164995.0, "length": 1502, "protein_name": "ATP-binding cassette sub-family C member 6", "gene_name": "Abcc6", "organism": "Rat", "refseq_name": "ATP-binding cassette sub-family C member 6", "refseq_ac": [ { "id": "NP_112275", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112275", "type": "external" } ], "gene_names_uniprotkb": "Abcc6; Mlp1; Mrp6", "gene_names_refseq": "Abcc6; Mrp6", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 6; 7.6.2.-; 7.6.2.3; MLP-1; MRP-like protein 1; Multidrug resistance-associated protein 6", "protein_names_refseq": "ATP-binding cassette sub-family C member 6; ATP-binding cassette, sub-family C (CFTR/MRP), member 6; ATP-binding cassette, subfamily C (CFTR/MRP), member 6; MLP-1; MRP-like protein 1; liver multidrug resistance-associated protein 6; multidrug resistance-associated protein 6", "tax_id": 10116, "disease": "arterial calcification of infancy (Disease Ontology:DOID:0050644); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (rno:81642); (R-RNO-382556)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10692506;21454685;22673903;24969777;24994603;28111129;33058196;9614210", "class_list": "", "function": "ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro) (By similarity). Also transports an anionic cyclopentapeptide endothelin antagonist, BQ-123 (PubMed:10692506). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity)., [UniProtKB, PubMed, UniProtKB]; In a rat model of CKD, ABCC6 protein expression was decreased in liver and kidney, however mRNA levels were unchanged., [RefSeq, PubMed]; In the absence of transfected rat ABCC6, HeLa and HEK293 cells released almost no ATP, but on induction of rat ABCC6, they released substantial amounts of ATP into the cell culture medium., [RefSeq, PubMed]; Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis., [UniProtKB, PubMed, PubMed]; This study suggests a critical role of hepatic ABCC6 in contributing to plasma inorganic pyrophosphate levels, identifying liver as a target of molecular correction to counteract ectopic mineralization in pseudoxanthoma elasticum, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0022857 transmembrane transporter activity;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:1904383 response to sodium phosphate;GO:0055085 transmembrane transport;GO:0006855 xenobiotic transmembrane transport;GO:0055062 phosphate ion homeostasis;GO:0055074 calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O88269-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88272-1", "uniprot_id": [ { "id": "MMP23_RAT", "url": "https://www.uniprot.org/uniprot/O88272", "type": "external" } ], "mass": 44618.0, "length": 391, "protein_name": "Matrix metalloproteinase-23", "gene_name": "Mmp23", "organism": "Rat", "refseq_name": "matrix metalloproteinase-23", "refseq_ac": [ { "id": "NP_446058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446058", "type": "external" } ], "gene_names_uniprotkb": "Mmp23; Mifr", "gene_names_refseq": "Mmp23", "protein_names_uniprotkb": "Matrix metalloproteinase-23; 3.4.24.-; MIFR; MMP-23; metalloprotease in the female reproductive tract", "protein_names_refseq": "MIFR; MMP-23; Matrix metalloproteinase 23; matrix metalloproteinase-23; metalloprotease in the female reproductive tract; metaloprotease in the female reproductive tract", "tax_id": 10116, "disease": "", "pathway": " (rno:94339)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11328856;19965868", "class_list": "", "function": "Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O88272-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88506-1", "uniprot_id": [ { "id": "STK39_RAT", "url": "https://www.uniprot.org/uniprot/O88506", "type": "external" } ], "mass": 60051.0, "length": 553, "protein_name": "STE20/SPS1-related proline-alanine-rich protein kinase", "gene_name": "Stk39", "organism": "Rat", "refseq_name": "STE20/SPS1-related proline-alanine-rich protein kinase", "refseq_ac": [ { "id": "NP_062235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062235", "type": "external" } ], "gene_names_uniprotkb": "Stk39; Pask; Spak", "gene_names_refseq": "Spak; Stk39", "protein_names_uniprotkb": "STE20/SPS1-related proline-alanine-rich protein kinase; 2.7.11.1; PS/TK; PSTK1; Pancreatic serine/threonine-protein kinase; Serine/threonine-protein kinase 39; Ste-20-related kinase", "protein_names_refseq": "PS/TK; PSTK1; STE20/SPS1-related proline-alanine-rich protein kinase; Ste-20 related kinase; pancreatic serine/threonine-protein kinase; serine/threonine-protein kinase 39; ste-20-related kinase", "tax_id": 10116, "disease": "Gitelman syndrome (Disease Ontology:DOID:0050450); pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (rno:54348)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10980603;10990492;12740379;16083423;16263722;22544747;22673903;34396440;35163352;9675032", "class_list": "", "function": "Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:22544747). Specifically recognizes and binds proteins with a RFXV motif (By similarity). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:22544747). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (By similarity). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:22544747). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (By similarity). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities. Phosphorylates RELT (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Inhibition of the pSPAK/pNKCC1 signaling pathway protects the bloodbrain barrier and reduces neuronal apoptosis in a rat model of surgical brain injury., [RefSeq, PubMed]; Kidney Injury Causes Accumulation of Renal Sodium That Modulates Renal Lymphatic Dynamics. Publication Status: Online-Only, [RefSeq, PubMed]; Roles in phosphorylation and activation of the Na-K-Cl cotransporter (NKCC1), [RefSeq, PubMed]; WNK1 and WNK4 both interacted with SPAK as well as a closely related kinase, termed oxidative stress response kinase-1 (OSR1)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70541", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0016020 membrane", "go_biological_process": "GO:0071476 cellular hypotonic response;GO:1901380 negative regulation of potassium ion transmembrane transport;GO:1990869 cellular response to chemokine;GO:0034763 negative regulation of transmembrane transport;GO:0030644 intracellular chloride ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O88506-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88582-1", "uniprot_id": [ { "id": "SOCS2_RAT", "url": "https://www.uniprot.org/uniprot/O88582", "type": "external" } ], "mass": 22380.0, "length": 198, "protein_name": "Suppressor of cytokine signaling 2", "gene_name": "Socs2", "organism": "Rat", "refseq_name": "suppressor of cytokine signaling 2", "refseq_ac": [ { "id": "NP_478115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_478115", "type": "external" } ], "gene_names_uniprotkb": "Socs2; Cish2", "gene_names_refseq": "Cish2; Socs-2; Socs2", "protein_names_uniprotkb": "Suppressor of cytokine signaling 2; Cytokine-inducible SH2 protein 2; SOCS-2", "protein_names_refseq": "cytokine inducible SH2-containing protein 2; cytokine-inducible SH2 protein 2; suppressor of cytokine signaling 2", "tax_id": 10116, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); endometrial cancer (Disease Ontology:DOID:1380); invasive ductal carcinoma (Disease Ontology:DOID:3008); ovarian carcinoma (Disease Ontology:DOID:4001)", "pathway": " (rno:84607); (R-RNO-8951664)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10579313;17986523;19008912;19469688;28867579", "class_list": "", "function": "Data show that althhough we observed OVX-related increases in SOCS2 and SOCS3 mRNA, SOCS2 and SOCS3 protein did not differ among groups., [RefSeq, PubMed]; Insulin can inhibit the mitogenic action of IGF-1 in mesangial cells by regulating STAT5/SOCS2 expression., [RefSeq, PubMed]; Research suggests that overexpressed SOCS2 might exacerbate myocardial ischemia/reperfusion injury in type 2 diabetes mellitus by inhibiting the expression of Insulin-like Growth Factor-1 via the Janus kinase-signal transducer and activator of transcription signaling pathway., [RefSeq, PubMed]; SOCS-2 may be involved in glial reactions, and possibly adult hippocampal neurogenesis during ischemic insults., [RefSeq, PubMed]; Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2. The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005159 insulin-like growth factor receptor binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0005131 growth hormone receptor binding;GO:0140031 phosphorylation-dependent protein binding;GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031466 Cul5-RING ubiquitin ligase complex", "go_biological_process": "GO:0060400 negative regulation of growth hormone receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0040014 regulation of multicellular organism growth;GO:0045666 positive regulation of neuron differentiation;GO:0032870 cellular response to hormone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O88582-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88823-1", "uniprot_id": [ { "id": "JTB_RAT", "url": "https://www.uniprot.org/uniprot/O88823", "type": "external" } ], "mass": 16385.0, "length": 146, "protein_name": "Protein JTB", "gene_name": "Jtb", "organism": "Rat", "refseq_name": "protein JTB precursor", "refseq_ac": [ { "id": "NP_062086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062086", "type": "external" } ], "gene_names_uniprotkb": "Jtb", "gene_names_refseq": "Jtb", "protein_names_uniprotkb": "Protein JTB", "protein_names_refseq": "protein JTB precursor; protein JTB-like; protein JTB", "tax_id": 10116, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); atrioventricular septal defect (Disease Ontology:DOID:0050651); primary ciliary dyskinesia 7 (Disease Ontology:DOID:0110605)", "pathway": " (rno:29439)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10321732", "class_list": "", "function": "Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005819 spindle;GO:0016020 membrane", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0042127 regulation of cell population proliferation;GO:0045860 positive regulation of protein kinase activity;GO:0000281 mitotic cytokinesis;GO:0008637 apoptotic mitochondrial changes", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O88823-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88941-1", "uniprot_id": [ { "id": "MOGS_RAT", "url": "https://www.uniprot.org/uniprot/O88941", "type": "external" } ], "mass": 91872.0, "length": 834, "protein_name": "Mannosyl-oligosaccharide glucosidase", "gene_name": "Mogs", "organism": "Rat", "refseq_name": "mannosyl-oligosaccharide glucosidase", "refseq_ac": [ { "id": "NP_113937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113937", "type": "external" } ], "gene_names_uniprotkb": "Mogs; Gcs1", "gene_names_refseq": "Gcs1; Mogs", "protein_names_uniprotkb": "Mannosyl-oligosaccharide glucosidase; 3.2.1.106; Glycoprotein-processing glucosidase I", "protein_names_refseq": "glucosidase 1; glycoprotein-processing glucosidase I; mannosyl-oligosaccharide glucosidase", "tax_id": 10116, "disease": "congenital disorder of glycosylation type IIb (Disease Ontology:DOID:0070254)", "pathway": " (rno:78947); (R-RNO-9768727)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1885588;38843836", "class_list": "glycogene;glycosylhydrolase", "function": "Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor., [UniProtKB, UniProtKB]; In the context of N-glycan degradation, cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.106", "type": "external" } ], "go_molecular_function": "GO:0004573 Glc3Man9GlcNAc2 oligosaccharide glucosidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0009311 oligosaccharide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O88941-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.1100000001000.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88994-1", "uniprot_id": [ { "id": "MARC2_RAT", "url": "https://www.uniprot.org/uniprot/O88994", "type": "external" } ], "mass": 38248.0, "length": 338, "protein_name": "Mitochondrial amidoxime reducing component 2", "gene_name": "Mtarc2", "organism": "Rat", "refseq_name": "mitochondrial amidoxime reducing component 2 precursor", "refseq_ac": [ { "id": "NP_599237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599237", "type": "external" } ], "gene_names_uniprotkb": "Mtarc2; Marc2; Mg87; Mosc2", "gene_names_refseq": "Marc2; Mg87; Mosc2; Mtarc2; mARC1", "protein_names_uniprotkb": "Mitochondrial amidoxime reducing component 2; 1.7.-.-; MOSC domain-containing protein 2; Moco sulfurase C-terminal domain-containing protein 2; Molybdenum cofactor sulfurase C-terminal domain-containing protein 2; mARC2", "protein_names_refseq": "MOCO sulphurase C-terminal domain containing 2; MOSC domain-containing protein 2, mitochondrial; mitochondrial amidoxime reducing component 2 precursor; moco sulfurase C-terminal domain-containing protein 2; molybdenum cofactor sulfurase C-terminal domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:171451); (R-RNO-211945)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22203676", "class_list": "", "function": "Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction., [UniProtKB, UniProtKB]; The presence of a novel reductive enzyme system of importance for lipid synthesis that is exclusively localized to the outer mitochondrial membrane and is composed of CYB5B, MOSC2, and a third unknown component (a CYB5B reductase)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0008940 nitrate reductase activity;GO:0030170 pyridoxal phosphate binding;GO:0043546 molybdopterin cofactor binding;GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome", "go_biological_process": "GO:0006809 nitric oxide biosynthetic process;GO:0042126 nitrate metabolic process;GO:0070458 cellular detoxification of nitrogen compound", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O88994-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01244-1", "uniprot_id": [ { "id": "SOMA_RAT", "url": "https://www.uniprot.org/uniprot/P01244", "type": "external" } ], "mass": 24656.0, "length": 216, "protein_name": "Somatotropin", "gene_name": "Gh1", "organism": "Rat", "refseq_name": "somatotropin precursor", "refseq_ac": [ { "id": "NP_001030020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030020", "type": "external" } ], "gene_names_uniprotkb": "Gh1; Gh", "gene_names_refseq": "Gh1; Ghb1; Gh; RNGHGP", "protein_names_uniprotkb": "Somatotropin; Growth hormone", "protein_names_refseq": "growth hormone b1; somatotropin precursor; somatotropin", "tax_id": 10116, "disease": "autoimmune polyendocrine syndrome type 1 (Disease Ontology:DOID:0050167); congenital hypothyroidism (Disease Ontology:DOID:0050328); isolated growth hormone deficiency (Disease Ontology:DOID:0060870); isolated growth hormone deficiency type II (Disease Ontology:DOID:0060872); isolated growth hormone deficiency type IA (Disease Ontology:DOID:0060873); isolated growth hormone deficiency type IB (Disease Ontology:DOID:0060874); osteoporosis (Disease Ontology:DOID:11476); gestational diabetes (Disease Ontology:DOID:11714); beta thalassemia (Disease Ontology:DOID:12241); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); anemia (Disease Ontology:DOID:2355); severe acute respiratory syndrome (Disease Ontology:DOID:2945); progeria (Disease Ontology:DOID:3911); myocardial infarction (Disease Ontology:DOID:5844); osteoarthritis (Disease Ontology:DOID:8398); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetes insipidus (Disease Ontology:DOID:9409); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:24391); (R-RNO-1170546); (R-RNO-422085); (R-RNO-982772)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "29080043;31059193;32084499;33799501;339105;37855319;6272224;6946433;8521139", "class_list": "", "function": "Chronic adult-onset of growth hormone/IGF-I hypersecretion improves cognitive functions and LTP and promotes neuronal differentiation in adult rats., [RefSeq, PubMed]; Diffuse traumatic brain injury substantially alters plasma growth hormone in the juvenile rat. Publication Status: Online-Only, [RefSeq, PubMed]; IGF1 exerts a negative feedback on GH secretion by a transcriptional mechanism., [RefSeq, PubMed]; Leptin Modulates the Response of Brown Adipose Tissue to Negative Energy Balance: Implication of the GH/IGF-I Axis. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-709 inhibits GHRP6 induced GH synthesis by targeting PRKCA in pituitary., [RefSeq, PubMed]; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0046872 metal ion binding;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0031012 extracellular matrix;GO:0070195 growth hormone receptor complex", "go_biological_process": "GO:0071469 cellular response to alkaline pH;GO:0048286 lung alveolus development;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P01244-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01681-1", "uniprot_id": [ { "id": "KVX01_RAT", "url": "https://www.uniprot.org/uniprot/P01681", "type": "external" } ], "mass": 11948.0, "length": 109, "protein_name": "Ig kappa chain V region S211", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig kappa chain V region S211", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "807630", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01681-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02761-1", "uniprot_id": [ { "id": "MUP_RAT", "url": "https://www.uniprot.org/uniprot/P02761", "type": "external" } ], "mass": 20737.0, "length": 181, "protein_name": "Major urinary protein", "gene_name": "", "organism": "Rat", "refseq_name": "major urinary protein precursor", "refseq_ac": [ { "id": "NP_001003409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003409", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "Mup4l1; Mup4l2; Mup; RGD1566134", "protein_names_uniprotkb": "Major urinary protein; Allergen Rat n I; Alpha(2)-euglobulin; Alpha-2u-globulin; MUP; alpha-2u globulin PGCL1", "protein_names_refseq": "allergen Rat n I; allergen n I; alpha(2)-euglobulin; alpha-2u globulin PGCL1; alpha-2u globulin PGCL2; alpha-2u-globulin (L type); alpha-2u-globulin; major urinary protein 4 like 2; major urinary protein precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:298109)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10833415;1279439;2005132;2443176;2468522;25797582;6163771;6167987;6183262;8645715", "class_list": "", "function": "Major urinary proteins (Mups) bind and release pheromones. They may also protect pheromones from oxidation. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance. Acts as a kairomone, detected by the prey vomeronasal organ and inducing fear reactions in mice., [UniProtKB]; Methyl isobutyl ketone exerts nephrotoxic effects through a protein droplet alpha2u nephropathy-mediated mode of action., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q54AE7", "ec_number_list": [], "go_molecular_function": "GO:0005009 insulin receptor activity;GO:0036094 small molecule binding;GO:0005550 pheromone binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0045834 positive regulation of lipid metabolic process;GO:0010888 negative regulation of lipid storage;GO:0010628 positive regulation of gene expression;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P02761-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04652-1", "uniprot_id": [ { "id": "TSHB_RAT", "url": "https://www.uniprot.org/uniprot/P04652", "type": "external" } ], "mass": 15505.0, "length": 138, "protein_name": "Thyrotropin subunit beta", "gene_name": "Tshb", "organism": "Rat", "refseq_name": "thyrotropin subunit beta precursor", "refseq_ac": [ { "id": "NP_037248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037248", "type": "external" } ], "gene_names_uniprotkb": "Tshb", "gene_names_refseq": "Tshb", "protein_names_uniprotkb": "Thyrotropin subunit beta; TSH-B; TSH-beta; Thyroid-stimulating hormone subunit beta; Thyrotropin beta chain", "protein_names_refseq": "TSH-B; TSH-beta; thyroid stimulating hormone, beta subunit; thyrotropin beta chain; thyrotropin subunit beta precursor; thyrotropin subunit beta", "tax_id": 10116, "disease": "congenital nongoitrous hypothyroidism 4 (Disease Ontology:DOID:0070123); hypothyroidism (Disease Ontology:DOID:1459); severe acute respiratory syndrome (Disease Ontology:DOID:2945); hyperglycemia (Disease Ontology:DOID:4195)", "pathway": " (rno:25653); (R-RNO-209822); (R-RNO-209968); (R-RNO-375281)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "17927662;18437010;21078364;3017658;3027091;3839124;6086256", "class_list": "", "function": "Indispensable for the control of thyroid structure and metabolism., [UniProtKB, UniProtKB, UniProtKB]; Results clearly show that there are diurnal changes in TSH expression and accumulation in rat PT-TSH cells and suggest that these fluctuations are regulated by melatonin., [RefSeq, PubMed]; TSH regulates Id2 expression, but that Id2 does not alter the expression of thyroid-specific genes, such as Tg, in FRTL-5 thyroid cells, [RefSeq, PubMed]; These data add new insight to an important role of T3 in rapidly regulating TSH beta gene expression at posttranscriptional level., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6GTA8", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005576 extracellular region", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0051592 response to calcium ion;GO:0033189 response to vitamin A;GO:0043627 response to estrogen", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P04652-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04904-1", "uniprot_id": [ { "id": "GSTA3_RAT", "url": "https://www.uniprot.org/uniprot/P04904", "type": "external" } ], "mass": 25319.0, "length": 221, "protein_name": "Glutathione S-transferase alpha-3", "gene_name": "Gsta3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gsta3; Gstyc1", "gene_names_refseq": "", "protein_names_uniprotkb": "Glutathione S-transferase alpha-3; 2.5.1.18; GST 2-2; GST A3-3; GST AA; GST Yc1; Glutathione S-transferase Yc-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24421); (R-RNO-156590); (R-RNO-9748787)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10215608;1953636;2186703;2985614;6204982;8051171", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively (By similarity). Has substantial activity toward aflatoxin B1-8,9-epoxide (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6LD92", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.145", "type": "external" }, { "id": "5.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.1", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0005504 fatty acid binding;GO:0004769 steroid Delta-isomerase activity;GO:0035731 dinitrosyl-iron complex binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0031667 response to nutrient levels;GO:0043651 linoleic acid metabolic process;GO:0006805 xenobiotic metabolic process;GO:0042178 xenobiotic catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P04904-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07871-1", "uniprot_id": [ { "id": "THIKB_RAT", "url": "https://www.uniprot.org/uniprot/P07871", "type": "external" } ], "mass": 43820.0, "length": 424, "protein_name": "3-ketoacyl-CoA thiolase B, peroxisomal", "gene_name": "Acaa1b", "organism": "Rat", "refseq_name": "3-ketoacyl-CoA thiolase B, peroxisomal precursor", "refseq_ac": [ { "id": "NP_001035108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035108", "type": "external" } ], "gene_names_uniprotkb": "Acaa1b; Acaa1", "gene_names_refseq": "Acaa1b; RGD1562373", "protein_names_uniprotkb": "3-ketoacyl-CoA thiolase B, peroxisomal; 2.3.1.155; 2.3.1.16; 2.3.1.9; Acetyl-CoA acyltransferase B; Beta-ketothiolase B; Peroxisomal 3-oxoacyl-CoA thiolase B", "protein_names_refseq": "3-ketoacyl-CoA thiolase B, peroxisomal precursor; 3-ketoacyl-CoA thiolase B, peroxisomal; acetyl-CoA acyltransferase B; beta-ketothiolase B; peroxisomal 3-ketoacyl-CoA thiolase B; peroxisomal 3-oxoacyl-CoA thiolase B", "tax_id": 10116, "disease": "", "pathway": " (rno:501072); (R-RNO-2046106); (R-RNO-390247); (R-RNO-6798695); (R-RNO-9033241)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "10064897;1680677;2307679;2882519;3036803", "class_list": "", "function": "Responsible for the thiolytic cleavage of straight chain 3-keto fatty acyl-CoAs (3-oxoacyl-CoAs) (PubMed:10064897, PubMed:2882519). Plays an important role in fatty acid peroxisomal beta-oxidation (PubMed:10064897, PubMed:2882519). Catalyzes the cleavage of short, medium, long, and very long straight chain 3-oxoacyl-CoAs (PubMed:10064897, PubMed:2882519). Medium chain straight 3-oxoacyl-CoAs are preferred substrates (PubMed:10064897)., [UniProtKB, PubMed, PubMed]; Responsible for the thiolytic cleavage of straight chain 3-keto fatty acyl-CoAs (3-oxoacyl-CoAs). Plays an important role in fatty acid peroxisomal beta-oxidation. Catalyzes the cleavage of short, medium, long, and very long straight chain 3-oxoacyl-CoAs. Medium chain straight 3-oxoacyl-CoAs are preferred substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4G049", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "1.14.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.18", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "2.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.26", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0003988 acetyl-CoA C-acyltransferase activity;GO:0003985 acetyl-CoA C-acetyltransferase activity;GO:0050633 acetyl-CoA C-myristoyltransferase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0010124 phenylacetate catabolic process;GO:0006635 fatty acid beta-oxidation;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase;GO:0006633 fatty acid biosynthetic process;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P07871-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07895-1", "uniprot_id": [ { "id": "SODM_RAT", "url": "https://www.uniprot.org/uniprot/P07895", "type": "external" } ], "mass": 24674.0, "length": 222, "protein_name": "Superoxide dismutase [Mn], mitochondrial", "gene_name": "Sod2", "organism": "Rat", "refseq_name": "superoxide dismutase [Mn], mitochondrial precursor", "refseq_ac": [ { "id": "NP_058747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058747", "type": "external" } ], "gene_names_uniprotkb": "Sod2", "gene_names_refseq": "MnSOD; Sod2", "protein_names_uniprotkb": "Superoxide dismutase [Mn], mitochondrial; 1.15.1.1", "protein_names_refseq": "Superoxide dimutase 2, mitochondrial; manganese superoxide dismutase; mitochondrial superoxide dismutase 2; superoxide dismutase 2, mitochondrial; superoxide dismutase [Mn], mitochondrial precursor; superoxide dismutase [Mn], mitochondrial", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); sensorineural hearing loss (Disease Ontology:DOID:10003); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); urinary bladder cancer (Disease Ontology:DOID:11054); adult respiratory distress syndrome (Disease Ontology:DOID:11394); osteoporosis (Disease Ontology:DOID:11476); diabetic angiopathy (Disease Ontology:DOID:11713); nephrotic syndrome (Disease Ontology:DOID:1184); optic neuritis (Disease Ontology:DOID:1210); primary biliary cholangitis (Disease Ontology:DOID:12236); vitiligo (Disease Ontology:DOID:12306); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); exfoliation syndrome (Disease Ontology:DOID:13641); polyneuropathy (Disease Ontology:DOID:1389); bladder neck obstruction (Disease Ontology:DOID:13948); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); Parkinson's disease (Disease Ontology:DOID:14330); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); hypothyroidism (Disease Ontology:DOID:1459); urticaria (Disease Ontology:DOID:1555); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); melanoma (Disease Ontology:DOID:1909); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); bilirubin metabolic disorder (Disease Ontology:DOID:2741); asthma (Disease Ontology:DOID:2841); carotid artery disease (Disease Ontology:DOID:3407); inclusion body myositis (Disease Ontology:DOID:3429); Canavan disease (Disease Ontology:DOID:3613); Leigh disease (Disease Ontology:DOID:3652); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); brain edema (Disease Ontology:DOID:4724); esophagus adenocarcinoma (Disease Ontology:DOID:4914); liver cirrhosis (Disease Ontology:DOID:5082); intestinal disease (Disease Ontology:DOID:5295); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); reactive arthritis (Disease Ontology:DOID:6196); hepatocellular carcinoma (Disease Ontology:DOID:684); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); abdominal aortic aneurysm (Disease Ontology:DOID:7693); infectious mononucleosis (Disease Ontology:DOID:8568); mycosis fungoides (Disease Ontology:DOID:8691); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24787); (R-RNO-2151201); (R-RNO-3299685)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "12791589;16399855;2001291;26446791;27213235;36153454;36922709;3697077;37921754;38007588;38659023", "class_list": "", "function": "Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems., [UniProtKB, PubMed]; Hippocampus mitochondrial MnSOD activation by a SIRT3 activator, honokiol, correlates with its deacetylation and upregulation of FoxO3a and PGC1alpha in a rat model of ammonia neurotoxicity., [RefSeq, PubMed]; Superoxide dismutase 2 scavenges ROS to promote osteogenic differentiation of human periodontal ligament stem cells by regulating Smad3 in alveolar bone-defective rats., [RefSeq, PubMed]; [Electroacupuncture preconditioning alleviates renal injury and oxidative stress through Sirt3/MnSOD pathway in type 2 diabetic rats]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 64, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" }, { "id": "1.14.12.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.12.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0019899 enzyme binding;GO:0030145 manganese ion binding;GO:0042802 identical protein binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0048773 erythrophore differentiation;GO:0034021 response to silicon dioxide;GO:1902631 negative regulation of membrane hyperpolarization;GO:0000303 response to superoxide;GO:0010729 positive regulation of hydrogen peroxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P07895-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08427-1", "uniprot_id": [ { "id": "SFTPA_RAT", "url": "https://www.uniprot.org/uniprot/P08427", "type": "external" } ], "mass": 26289.0, "length": 248, "protein_name": "Pulmonary surfactant-associated protein A", "gene_name": "Sftpa1", "organism": "Rat", "refseq_name": "pulmonary surfactant-associated protein A isoform 1 precursor", "refseq_ac": [ { "id": "NP_001257574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257574", "type": "external" } ], "gene_names_uniprotkb": "Sftpa1; Sftp-1; Sftp1; Sftpa", "gene_names_refseq": "PSAP; PSP-A; SP-A; Sftp1; Sftpa1; Sftpa; Sftpl", "protein_names_uniprotkb": "Pulmonary surfactant-associated protein A; PSAP; PSP-A; SP-A", "protein_names_refseq": "Surfactant-associated protein 1 (pulmonary surfactant protein, SP-A); pulmonary surfactant-associated protein A isoform 1 precursor; pulmonary surfactant-associated protein A-like; pulmonary surfactant-associated protein A; surfactant, pulmonary-associated protein A1", "tax_id": 10116, "disease": "sinusitis (Disease Ontology:DOID:0050127); interstitial lung disease 1 (Disease Ontology:DOID:0060941); interstitial lung disease 2 (Disease Ontology:DOID:0060971); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); adult respiratory distress syndrome (Disease Ontology:DOID:11394); pulmonary edema (Disease Ontology:DOID:11396); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); leiomyoma (Disease Ontology:DOID:127); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); pulmonary sarcoidosis (Disease Ontology:DOID:13406); endometrial cancer (Disease Ontology:DOID:1380); cystic fibrosis (Disease Ontology:DOID:1485); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); schizophrenia (Disease Ontology:DOID:5419); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); extrinsic allergic alveolitis (Disease Ontology:DOID:841); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874); cleft lip (Disease Ontology:DOID:9296); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24773); (R-RNO-166016); (R-RNO-391160); (R-RNO-5683826); (R-RNO-5686938)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "12913002;21047777;25242514;28719181;2901856;30055742;33267655;34777371;3579914;38483982;7491978", "class_list": "", "function": "In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages., [UniProtKB, UniProtKB]; SP-A expression was up-regulated in the middle ear effusion of non-typeable Haemophilus influenza otitis media., [RefSeq, PubMed]; SPA binds dipalmitoyl-phosphatidylcholine, the major surfactant lipid component, but not phosphatidylinositol; SPD exhibits the opposite preference. Data suggest flexibility in a key surface loop supports distinctive lipid binding of SPA; quadruple mutant SPA (E171D/P175E/R197N/K203D) that introduces SPD-like loop-stabilizing Ca2+ binding site in carbohydrate recognition domain exhibits ligand-binding preferences of SPD., [RefSeq, PubMed]; Surfactant Protein A, a Novel Regulator for Smooth Muscle Phenotypic Modulation and Vascular Remodeling-Brief Report., [RefSeq, PubMed]; Surfactant Proteins A/D-CD14 on Alveolar Macrophages Is a Common Pathway Associated With Phagocytosis of Nanomaterials and Cytokine Production. Publication Status: Online-Only, [RefSeq, PubMed]; The expression of the surfactant proteins SP-A and SP-B during postnatal alveolarization of the rat lung. Erratum:[PLoS One. 2025 Aug 6;20(8):e0329954. doi: 10.1371/journal.pone.0329954. PMID: 40768498] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005771 multivesicular body", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0001666 response to hypoxia;GO:0007585 respiratory gaseous exchange by respiratory system;GO:0051384 response to glucocorticoid;GO:0032526 response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P08427-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000100010000.011.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08430-1", "uniprot_id": [ { "id": "UD16_RAT", "url": "https://www.uniprot.org/uniprot/P08430", "type": "external" } ], "mass": 60132.0, "length": 529, "protein_name": "UDP-glucuronosyltransferase 1A6", "gene_name": "Ugt1a2; Ugt1a5; Ugt1a6a; Ugt1a6; Ugt1a8", "organism": "Rat", "refseq_name": "UDP-glucuronosyltransferase 1A6 precursor", "refseq_ac": [ { "id": "NP_001034780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034780", "type": "external" } ], "gene_names_uniprotkb": "Ugt1a2; Ugt1a5; Ugt1a6a; Ugt1a6; Ugt1a8; Ugt1a1; Ugt1a2; Ugt1a3; Ugt1a5; Ugt1a6a; Ugt1a6; Ugt1a7c; Ugt1a9; Ugt1", "gene_names_refseq": "UDPGT 1-6; UGT1-06; UGT1.6; Udpgt; Ugt1a6a; Ugt1a6; Ugt1a7; Ugt1", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 1A6; 2.4.1.17; A1; P-nitrophenol-specific UDPGT; UDP-glucuronosyltransferase 1-6; UDPGT 1-6; UGT1*6; UGT1-06; UGT1.6; UGT1A6", "protein_names_refseq": "P-nitrophenol specific; P-nitrophenol-specific UDPGT; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glucuronosyltransferase 1A6; UDP glucuronosyltransferase family 1 member A6; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1-6; UDP-glucuronosyltransferase 1A6 precursor", "tax_id": 10116, "disease": "hepatitis B (Disease Ontology:DOID:2043); cholangiocarcinoma (Disease Ontology:DOID:4947); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:113992); (rno:154516); (rno:396527); (rno:574523); (R-RNO-156588); (R-RNO-9749641); (R-RNO-9753281)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "22673903;24694608;26725430;29131354;3096993;38163420", "class_list": "glycogene;glycosyltransferase", "function": "Bile duct ligation elevates 5-HT levels in cerebral cortex of rats partly due to impairment of brain UGT1A6 expression and activity via ammonia accumulation., [RefSeq, PubMed]; Results indicate that adrenal-dependent factors such as glucocorticoids are partially involved in the basal regulation of UGT1A6 and UGT1A7 transcription., [RefSeq, PubMed]; Study indicated that Status Epilepticus altered the expression of brain Ugt1a1 and Ugt1a7, which could alter glucuronidation in the brain., [RefSeq, PubMed]; This study clarified that Ugt1a6 and Ugt1a7 mRNA expression and their enzyme activities were altered by beta-naphthoflavone, suggesting that these changes may lead to alteration in the pharmacokinetics of UGT substrate in rat brain., [RefSeq, PubMed]; UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to facilitate their inactivation and excretion from the body. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE and 20-HETE (By similarity). Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate (By similarity). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" } ], "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex;GO:1902494 catalytic complex", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:1904010 response to Aroclor 1254;GO:1904681 response to 3-methylcholanthrene;GO:0001889 liver development;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P08430-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000010001.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09006-1", "uniprot_id": [ { "id": "SPA3N_RAT", "url": "https://www.uniprot.org/uniprot/P09006", "type": "external" } ], "mass": 46652.0, "length": 418, "protein_name": "Serine protease inhibitor A3N", "gene_name": "Serpina3n", "organism": "Rat", "refseq_name": "serine protease inhibitor A3N precursor", "refseq_ac": [ { "id": "NP_113719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113719", "type": "external" } ], "gene_names_uniprotkb": "Serpina3n; Spin2c", "gene_names_refseq": "CPi-26; SPI3; Serpina3n; Spi-2.2; Spin2c; Spin3", "protein_names_uniprotkb": "Serine protease inhibitor A3N; CPI-26; Contrapsin-like protease inhibitor 6; SPI-2.2; SPI-3; Serine protease inhibitor 3; Serpin A3N", "protein_names_refseq": "SPI-3; contrapsin-like protease inhibitor 6; serine (or cysteine) peptidase inhibitor, clade A, member 3N; serine protease inhibitor 2c; serine protease inhibitor 3; serine protease inhibitor A3N precursor; serine protease inhibitor A3N; serpin A3N; serpina3n-like protein", "tax_id": 10116, "disease": "adult respiratory distress syndrome (Disease Ontology:DOID:11394); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); uveitis (Disease Ontology:DOID:13141); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); cystic fibrosis (Disease Ontology:DOID:1485); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung adenocarcinoma (Disease Ontology:DOID:3910); vasculitis (Disease Ontology:DOID:865)", "pathway": " (rno:24795); (R-RNO-114608); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1039/D0MO00044B;14985449;15638460;1694763;1864837;22673903;23007996;25915831;34106099;3493437", "class_list": "", "function": "SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase, [RefSeq, PubMed]; The sequence of HM448398 was highly homologous to that of rat Serpina3n, suggesting that it may be a homolog of Serpina3n. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 9, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q03312", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0071320 cellular response to cAMP;GO:0009617 response to bacterium;GO:0034097 response to cytokine;GO:0043434 response to peptide hormone", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P09006-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09650-1", "uniprot_id": [ { "id": "MCPT1_RAT", "url": "https://www.uniprot.org/uniprot/P09650", "type": "external" } ], "mass": 28617.0, "length": 260, "protein_name": "Mast cell protease 1", "gene_name": "Mcpt1", "organism": "Rat", "refseq_name": "mast cell protease 1 preproprotein", "refseq_ac": [ { "id": "NP_001264597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264597", "type": "external" } ], "gene_names_uniprotkb": "Mcpt1", "gene_names_refseq": "Mcpt1l1; Mcpt1; rMCP-1; rMCP-I", "protein_names_uniprotkb": "Mast cell protease 1; 3.4.21.39; CLIP protein; Chymase; Chymotrypsin-like protease; Mast cell protease I; rMCP-1; rMCP-I", "protein_names_refseq": "CLIP protein; chymase; chymotrypsin-like protease; mast cell protease 1 preproprotein; mast cell protease 1; mast cell protease I; protease 1-like", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); primary bacterial infectious disease (Disease Ontology:DOID:0050338); hypothyroidism (Disease Ontology:DOID:1459); phenylketonuria (Disease Ontology:DOID:9281)", "pathway": " (rno:100360872)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "103093;3122823;8135800;8336143;8996238", "class_list": "", "function": "Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. May participate in generating perivascular beta-protein which ultimately aggregates into amyloid-beta deposits., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P09650-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09656-1", "uniprot_id": [ { "id": "ISK1L_RAT", "url": "https://www.uniprot.org/uniprot/P09656", "type": "external" } ], "mass": 8565.0, "length": 79, "protein_name": "Serine protease inhibitor Kazal-type 1-like", "gene_name": "Spink1l", "organism": "Rat", "refseq_name": "serine protease inhibitor Kazal-type 1-like precursor", "refseq_ac": [ { "id": "NP_690919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690919", "type": "external" } ], "gene_names_uniprotkb": "Spink1l; Spink3", "gene_names_refseq": "PSTI-56; Psti; Spink1l; Spink1; Spink3", "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 1-like; Calcium transport inhibitor; Caltrin; PSTI-II; Pancreatic secretory trypsin inhibitor II", "protein_names_refseq": "calcium transport inhibitor; caltrin; pancreatic secretory trypsin inhibitor II; pancreatic secretory trypsin inhibitor type II (PSTI-II); pancreatic secretory trypsin inhibitor-56; serine peptidase inhibitor, Kazal type 1; serine peptidase inhibitor, Kazal type 3; serine protease inhibitor Kazal-type 1-like precursor; serine protease inhibitor Kazal-type 1-like; serine protease inhibitor Kazal-type 3-like; serine protease inhibitor Kazal-type 3", "tax_id": 10116, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); ovary epithelial cancer (Disease Ontology:DOID:2152); transitional cell carcinoma (Disease Ontology:DOID:2671); endometriosis (Disease Ontology:DOID:289); cervical adenocarcinoma (Disease Ontology:DOID:3702); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (rno:266602)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1390891;1400406;2110056;2751646;3202973", "class_list": "", "function": "In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production., [UniProtKB, PubMed]; Serine protease inhibitor which exhibits anti-trypsin activity (PubMed:2110056, PubMed:3202973). In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P09656-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09916-1", "uniprot_id": [ { "id": "SLIB_RAT", "url": "https://www.uniprot.org/uniprot/P09916", "type": "external" } ], "mass": 12266.0, "length": 104, "protein_name": "Somatoliberin", "gene_name": "Ghrh", "organism": "Rat", "refseq_name": "somatoliberin precursor", "refseq_ac": [ { "id": "NP_113765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113765", "type": "external" } ], "gene_names_uniprotkb": "Ghrh", "gene_names_refseq": "GHRF; Ghrh", "protein_names_uniprotkb": "Somatoliberin; GHRH; GRF; Growth hormone-releasing factor; Growth hormone-releasing hormone", "protein_names_refseq": "GRF; growth hormone-releasing factor; somatoliberin precursor; somatoliberin", "tax_id": 10116, "disease": "autoimmune polyendocrine syndrome type 1 (Disease Ontology:DOID:0050167); obstructive sleep apnea (Disease Ontology:DOID:0050848); isolated growth hormone deficiency type IA (Disease Ontology:DOID:0060873); prostate carcinoma (Disease Ontology:DOID:10286); prostatic hypertrophy (Disease Ontology:DOID:11132); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); endometriosis (Disease Ontology:DOID:289); renal cell carcinoma (Disease Ontology:DOID:4450); sleep disorder (Disease Ontology:DOID:535); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:29446); (R-RNO-420092)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1924334;24373935;26831066;27480202;37572878;3920534;6406907;7895659", "class_list": "", "function": "Findings support the hypothesis that antagonizing the signaling of GHRH in T1D may improve GLP-1 function in the small intestine, which, in turn, diminishes TRL and reduces renal and vascular complications, [RefSeq, PubMed]; GHRH Neurons from the Ventromedial Hypothalamic Nucleus Provide Dynamic and Sex-Specific Input to the Brain Glucose-Regulatory Network., [RefSeq, PubMed]; GHRH agonistic analogs, JI-34 and MR-356 alleviated radiation-induced damage of cardiac myocytes., [RefSeq, PubMed]; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone., [UniProtKB]; JI-38 had shown promising results in multiple fields including cardiology, diabetes and wound healing, our new, more potent, GHRH agonists should manifest additional efficacy for possible medical applications., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031770 growth hormone-releasing hormone receptor binding;GO:0005184 neuropeptide hormone activity;GO:0051428 peptide hormone receptor binding;GO:0016608 growth hormone-releasing hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0043195 terminal bouton;GO:0043204 perikaryon;GO:0043679 axon terminus", "go_biological_process": "GO:0021984 adenohypophysis development;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008284 positive regulation of cell population proliferation;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P09916-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C0A9-1", "uniprot_id": [ { "id": "SVIP_RAT", "url": "https://www.uniprot.org/uniprot/P0C0A9", "type": "external" } ], "mass": 8248.0, "length": 76, "protein_name": "Small VCP/p97-interacting protein", "gene_name": "Svip", "organism": "Rat", "refseq_name": "small VCP/p97-interacting protein", "refseq_ac": [ { "id": "NP_001258013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258013", "type": "external" } ], "gene_names_uniprotkb": "Svip", "gene_names_refseq": "RGD1565432; Svip", "protein_names_uniprotkb": "Small VCP/p97-interacting protein", "protein_names_refseq": "small VCP/p97-interacting protein", "tax_id": 10116, "disease": "syndrome (Disease Ontology:DOID:225)", "pathway": " (rno:499157); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12529442;24055875;27129256;30683843;35042898", "class_list": "", "function": "Data sugggest that small valosin-containing protein-interacting protein (SVIP) acts as a regulator of VLDL transport vesicle (VTV) formation by interacting with its cargo and coat proteins., [RefSeq, PubMed]; Negative regulator of the ER-associated degradation pathway (ERAD) of misfolded proteins. It competes with AMFR/gp78 for binding VCP/p97, and inhibits AMFR/gp78-VCP/p97 complex formation that is required for degradation of ERAD substrates. Involved in the regulation of adrenal cortisol and dehydroepiandrosterone (DHEA) biosynthesis., [UniProtKB, UniProtKB]; SVIP and valosin containing protein were seen to be co-localized in neuronal cell bodies., [RefSeq, PubMed]; SVIP is closely associated with the level of autophagy during the development of CCl4-induced hepatic fibrosis. SVIP can induce autophagy and suspend hepatic fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010508 positive regulation of autophagy;GO:0031333 negative regulation of protein-containing complex assembly;GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process;GO:1904240 negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly;GO:1904153 negative regulation of retrograde protein transport, ER to cytosol", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0C0A9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C1G9-1", "uniprot_id": [ { "id": "SOX11_RAT", "url": "https://www.uniprot.org/uniprot/P0C1G9", "type": "external" } ], "mass": 42599.0, "length": 395, "protein_name": "Transcription factor SOX-11", "gene_name": "Sox11", "organism": "Rat", "refseq_name": "transcription factor SOX-11", "refseq_ac": [ { "id": "NP_445801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445801", "type": "external" } ], "gene_names_uniprotkb": "Sox11", "gene_names_refseq": "Sox11", "protein_names_uniprotkb": "Transcription factor SOX-11", "protein_names_refseq": "SRY (sex determining region Y)-box 11; SRY box 11; SRY-box containing gene 11; transcription factor SOX-11", "tax_id": 10116, "disease": "Coffin-Siris syndrome 9 (Disease Ontology:DOID:0070057); Coffin-Siris syndrome (Disease Ontology:DOID:1925); Weissenbacher-Zweymuller syndrome (Disease Ontology:DOID:4258)", "pathway": " (rno:84046)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "25466891;31916393;32935389;38407972;39135278;9632656", "class_list": "", "function": "Downregulation of SOX11 in fetal heart tissue, under hyperglycemic environment, mediates cardiomyocytes apoptosis., [RefSeq, PubMed]; GAS5, a long noncoding RNA, contributes to annulus fibroblast osteogenic differentiation and apoptosis in intervertebral disk degeneration via the miR-221-3p/SOX11 axis., [RefSeq, PubMed]; Investigated the role of Sox11 in regulating trilineage differentiation (osteogenesis, adipogenesis, and chondrogenesis) and migration of mesenchymal stem cells, [RefSeq, PubMed]; MiR-141 inhibited the proliferation of bone marrow mesenchymal stem cells (BMSC) in steroid-induced avascular necrosis of the femoral head by targeting SOX11. Inhibition of miR-141 upregulated the expression of SOX11 and promoted the proliferation of BMSC., [RefSeq, PubMed]; MicroRNA-125b-5p alleviated CCI-induced neuropathic pain and modulated neuroinflammation via targeting SOX11., [RefSeq, PubMed]; Transcription factor that acts as a transcriptional activator (By similarity). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35178;O89036;Q04889", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:2000648 positive regulation of stem cell proliferation;GO:0021782 glial cell development;GO:0061386 closure of optic fissure;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P0C1G9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C2N6-1", "uniprot_id": [ { "id": "KMT5C_RAT", "url": "https://www.uniprot.org/uniprot/P0C2N6", "type": "external" } ], "mass": 53607.0, "length": 470, "protein_name": "Histone-lysine N-methyltransferase KMT5C", "gene_name": "Kmt5c", "organism": "Rat", "refseq_name": "histone-lysine N-methyltransferase KMT5C", "refseq_ac": [ { "id": "NP_001100945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100945", "type": "external" } ], "gene_names_uniprotkb": "Kmt5c; Suv420h2", "gene_names_refseq": "Kmt5c; Suv420h2", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase KMT5C; 2.1.1.361; 2.1.1.362; Lysine-specific methyltransferase 5C; Su(var)4-20 homolog 2; Suppressor of variegation 4-20 homolog 2; Suv4-20h2; [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; [histone H4]-lysine20 N-methyltransferase KMT5B", "protein_names_refseq": "[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; [histone H4]-lysine20 N-methyltransferase KMT5B; histone-lysine N-methyltransferase KMT5C; histone-lysine N-methyltransferase SUV420H2; lysine (K)-specific methyltransferase 5C; lysine-specific methyltransferase 5C; su(var)4-20 homolog 2; suppressor of variegation 4-20 homolog 2; suv4-20h2", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); liver benign neoplasm (Disease Ontology:DOID:916)", "pathway": " (rno:308345); (R-RNO-3214841)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16497704;17182829", "class_list": "", "function": "Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Suv4-20h2 and Suv-39h1 histone methyltransferases are expressed and Histone H3 lysine 9 and H4 lysine 20 are trimethylated in hepatocarcinogenesis induced by methyl deficiency in rats [Suv4-20h2 and Suv-39h1], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0042393 histone binding;GO:1904047 S-adenosyl-L-methionine binding;GO:0042799 histone H4K20 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000792 heterochromatin;GO:0000779 condensed chromosome, centromeric region;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0032259 methylation;GO:0045830 positive regulation of isotype switching", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0C2N6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C5H9-1", "uniprot_id": [ { "id": "MANF_RAT", "url": "https://www.uniprot.org/uniprot/P0C5H9", "type": "external" } ], "mass": 20388.0, "length": 179, "protein_name": "Mesencephalic astrocyte-derived neurotrophic factor", "gene_name": "Manf", "organism": "Rat", "refseq_name": "mesencephalic astrocyte-derived neurotrophic factor precursor", "refseq_ac": [ { "id": "NP_001387993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001387993", "type": "external" } ], "gene_names_uniprotkb": "Manf; Armet", "gene_names_refseq": "Armet; Manf", "protein_names_uniprotkb": "Mesencephalic astrocyte-derived neurotrophic factor; Arginine-rich protein; Protein ARMET", "protein_names_refseq": "arginine-rich protein; arginine-rich, mutated in early stage tumors; mesencephalic astrocyte-derived neurotrophic factor precursor", "tax_id": 10116, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); bacterial infectious disease (Disease Ontology:DOID:104); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (rno:315989); (R-RNO-114608)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12794311;16462600;30211660;32613670;32757264;38159526", "class_list": "", "function": "DHA modulates MANF and TREM2 abundance, enhances neurogenesis, reduces infarct size, and improves neurological function after experimental ischemic stroke., [RefSeq, PubMed]; Deletion of mesencephalic astrocyte-derived neurotrophic factor delays and damages the development of white pulp in spleen., [RefSeq, PubMed]; Functional analysis of mesencephalic astrocyte-derived neurotrophic factor in retinal ganglion cells under oxidative stress., [RefSeq, PubMed]; Mesencephalic astrocyte-derived neurotrophic factor showed not only transient but also long-lasting neuroprotective properties, [RefSeq, PubMed]; Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain (By similarity). Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra (PubMed:16462600). Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (PubMed:16462600). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death (By similarity). Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions (By similarity). Stabilizes HSPA5/BiP in its substrate-bound ADP state, which facilitates HSPA5/BiP incorporation into chaperone-client complexes during endoplasmic reticulum stress, its interaction with HSPA5/BiP inhibits ATP binding to HSPA5/BiP and subsequent nucleotide exchange (By similarity). As a result acts as a repressor of the unfolded protein response (UPR) pathway (By similarity). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia (By similarity). Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells (By similarity). Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions (By similarity). Essential for embryonic lung development (By similarity). Required for the correct postnatal temporal and structural development of splenic white pulp (By similarity). Required for the repair-associated myeloid response in skeletal muscle, acts as a regulator of phenotypic transition towards prorepair macrophages in response to muscle injury and as a result limits excessive proinflammatory signaling (By similarity). Represses RELA expression and therefore NF-kB signaling in the myocardium, as a result limits macrophage infiltration of injured tissue and M1 macrophage differentiation in response to myocardial injury (By similarity). Required for endochondral ossification in long bones and the skull during postnatal development (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0120146 sulfatide binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0048471 perinuclear region of cytoplasm;GO:0033018 sarcoplasmic reticulum lumen", "go_biological_process": "GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure;GO:0031175 neuron projection development;GO:0036500 ATF6-mediated unfolded protein response;GO:0071542 dopaminergic neuron differentiation;GO:1905897 regulation of response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P0C5H9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C5J9-1", "uniprot_id": [ { "id": "SHKB1_RAT", "url": "https://www.uniprot.org/uniprot/P0C5J9", "type": "external" } ], "mass": 75972.0, "length": 704, "protein_name": "SH3KBP1-binding protein 1", "gene_name": "Shkbp1", "organism": "Rat", "refseq_name": "SH3KBP1-binding protein 1", "refseq_ac": [ { "id": "NP_001258009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258009", "type": "external" } ], "gene_names_uniprotkb": "Shkbp1; Sb1", "gene_names_refseq": "RGD1309281; Sb1; Shkbp1", "protein_names_uniprotkb": "SH3KBP1-binding protein 1; SETA-binding protein 1", "protein_names_refseq": "SETA-binding protein 1; SH3KBP1-binding protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:292735)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11152963", "class_list": "", "function": "Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C5J9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C6R4-1", "uniprot_id": [ { "id": "IFFO2_RAT", "url": "https://www.uniprot.org/uniprot/P0C6R4", "type": "external" } ], "mass": 33000.0, "length": 287, "protein_name": "Intermediate filament family orphan 2", "gene_name": "Iffo2; Tas1r2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Iffo2; Tas1r2; Iffo2", "gene_names_refseq": "", "protein_names_uniprotkb": "Intermediate filament family orphan 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005882 intermediate filament;GO:0005886 plasma membrane", "go_biological_process": "GO:0050912 detection of chemical stimulus involved in sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C6R4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CC10-1", "uniprot_id": [ { "id": "LRC4B_RAT", "url": "https://www.uniprot.org/uniprot/P0CC10", "type": "external" } ], "mass": 76119.0, "length": 709, "protein_name": "Leucine-rich repeat-containing protein 4B", "gene_name": "Lrrc4b", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 4B precursor", "refseq_ac": [ { "id": "NP_001258010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258010", "type": "external" } ], "gene_names_uniprotkb": "Lrrc4b; Lrig4", "gene_names_refseq": "Lrig4; Lrrc4b; NGL-3", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 4B; NGL-3; Netrin-G3 ligand", "protein_names_refseq": "leucine-rich repeat-containing protein 4B precursor; leucine-rich repeat-containing protein 4B; netrin-G3 ligand; protein NGL-3", "tax_id": 10116, "disease": "", "pathway": " (rno:308571); (R-RNO-388844)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16980967;19252495;24090084;38843836", "class_list": "", "function": "Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:0044300 cerebellar mossy fiber;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0051965 positive regulation of synapse assembly;GO:0099560 synaptic membrane adhesion;GO:1905606 regulation of presynapse assembly;GO:0099151 regulation of postsynaptic density assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P0CC10-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CD94-1", "uniprot_id": [ { "id": "UQCC3_RAT", "url": "https://www.uniprot.org/uniprot/P0CD94", "type": "external" } ], "mass": 9678.0, "length": 89, "protein_name": "Ubiquinol-cytochrome-c reductase complex assembly factor 3", "gene_name": "Uqcc3", "organism": "Rat", "refseq_name": "uncharacterized protein LOC690344", "refseq_ac": [ { "id": "NP_001162132", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162132", "type": "external" } ], "gene_names_uniprotkb": "Uqcc3", "gene_names_refseq": "Uqcc3", "protein_names_uniprotkb": "Ubiquinol-cytochrome-c reductase complex assembly factor 3", "protein_names_refseq": "uncharacterized protein LOC690344", "tax_id": 10116, "disease": "mitochondrial complex III deficiency nuclear type 9 (Disease Ontology:DOID:0080118)", "pathway": " (rno:690344)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070300 phosphatidic acid binding;GO:1901612 cardiolipin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006754 ATP biosynthetic process;GO:0042407 cristae formation;GO:0034551 mitochondrial respiratory chain complex III assembly;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0CD94-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CE46-1", "uniprot_id": [ { "id": "ZNT8_RAT", "url": "https://www.uniprot.org/uniprot/P0CE46", "type": "external" } ], "mass": 40128.0, "length": 368, "protein_name": "Proton-coupled zinc antiporter SLC30A8", "gene_name": "Slc30a8", "organism": "Rat", "refseq_name": "proton-coupled zinc antiporter SLC30A8", "refseq_ac": [ { "id": "NP_001124010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124010", "type": "external" } ], "gene_names_uniprotkb": "Slc30a8; Znt8", "gene_names_refseq": "Slc30a8; ZnT-8", "protein_names_uniprotkb": "Proton-coupled zinc antiporter SLC30A8; Solute carrier family 30 member 8; Zinc transporter 8; ZnT-8", "protein_names_refseq": "proton-coupled zinc antiporter SLC30A8; solute carrier family 30 (zinc transporter), member 8; zinc transporter 8", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:299903); (R-RNO-264876); (R-RNO-435368)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "19095428;19243577;19479076;21208276;23209723;26281917;26720469", "class_list": "", "function": "Both ZnT3 and ZnT8 seem to play a role in beta-cell survival and the ability of these cells to react appropriately to surrounding glucose concentrations., [RefSeq, PubMed]; Diabetes caused reductions in the serum and pancreatic zinc levels and pancreatic ZnT8 expression. Following moderate exercise training, there was a significant increase in all of these parameters., [RefSeq, PubMed]; Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands., [RefSeq, PubMed]; In diabetic retinas, EPO maintains zinc homeostasis through activating the ERK pathway and downregulating HIF-1alpha, and thus upregulating ZnT8 expression., [RefSeq, PubMed]; Ischemic retinopathy maybe mediated by aberrant Zn(++) homeostasis caused by ZnT8 downregulation, whereas YC-1 plays a neuroprotective role against ischemic insult, [RefSeq, PubMed]; Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0140826 zinc:proton antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030141 secretory granule;GO:0030658 transport vesicle membrane;GO:0030667 secretory granule membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0010043 response to zinc ion;GO:0032024 positive regulation of insulin secretion;GO:0060627 regulation of vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P0CE46-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DKR2-1", "uniprot_id": [ { "id": "TCAIM_RAT", "url": "https://www.uniprot.org/uniprot/P0DKR2", "type": "external" } ], "mass": 58413.0, "length": 505, "protein_name": "T-cell activation inhibitor, mitochondrial", "gene_name": "Tcaim", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tcaim; Toag1", "gene_names_refseq": "", "protein_names_uniprotkb": "T-cell activation inhibitor, mitochondrial; TOAG-1; Tolerance-associated gene-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:363169)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17456197", "class_list": "", "function": "May regulate T-cell apoptosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6I484", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0DKR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10960-1", "uniprot_id": [ { "id": "SAP_RAT", "url": "https://www.uniprot.org/uniprot/P10960", "type": "external" } ], "mass": 61124.0, "length": 554, "protein_name": "Prosaposin", "gene_name": "Psap", "organism": "Rat", "refseq_name": "prosaposin isoform B preproprotein", "refseq_ac": [ { "id": "NP_001177165", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177165", "type": "external" } ], "gene_names_uniprotkb": "Psap; Sgp1", "gene_names_refseq": "Psap; SGP-1; SGP1A", "protein_names_uniprotkb": "Prosaposin; SGP-1; Sulfated glycoprotein 1", "protein_names_refseq": "prosaposin (sulfated glycoprotein, sphingolipid hydrolase activator); prosaposin isoform B preproprotein; sulfated glycoprotein 1", "tax_id": 10116, "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); atypical Gaucher's disease due to saposin c deficiency (Disease Ontology:DOID:0110961); combined saposin deficiency (Disease Ontology:DOID:0111330); metachromatic leukodystrophy (Disease Ontology:DOID:10581); Krabbe disease (Disease Ontology:DOID:10587); asthma (Disease Ontology:DOID:2841); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (rno:25524); (R-RNO-114608); (R-RNO-375276); (R-RNO-418594); (R-RNO-6798695); (R-RNO-9840310)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "15240697;29656342;3048385;31215019;33259479;33914781;37208379;41085015;8573994;8601692", "class_list": "", "function": "Acts as a lysosomal activator protein that stimulates acid ceramidase (EC 3.5.1.23) by solubilizing and presenting ceramide substrates at the lipid-water interface, facilitating their hydrolysis into sphingosine and fatty acids. It also activates acid sphingomyelinase (EC 3.1.4.12), though ceramide catabolism represents its primary physiological role., [UniProtKB, UniProtKB]; Acts as an essential lysosomal cofactor that activates acid beta-glucosylceramidases (EC 3.2.1.45) by altering lipid bilayer properties to facilitate enzyme access to its membrane-embedded glucosylceramide substrate, while also protecting glucocerebrosidase from intralysosomal proteolytic degradation., [UniProtKB, UniProtKB]; Age- and sex-associated changes in prosaposin and its receptors in the lacrimal glands of rats., [RefSeq, PubMed]; Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling., [UniProtKB, UniProtKB, UniProtKB]; Castration causes an increase in lysosomal size and upregulation of cathepsin D expression in principal cells along with increased secretion of procathepsin D and prosaposin oligomers in adult rat epididymis. Publication Status: Online-Only, [RefSeq, PubMed]; Prosaposin PS18 reduces dopaminergic neurodegeneration in a 6-hydroxydopamine rat model of Parkinson's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Prosaposin and its receptors GRP37 and GPR37L1 show increased immunoreactivity in the facial nucleus following facial nerve transection. Publication Status: Online-Only, [RefSeq, PubMed]; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Saposins are specific low-molecular mass non-enzymatic glycoproteins that act as activator proteins for lysosomal sphingolipid-degrading enzymes, facilitating the hydrolysis of sphingolipids by extracting lipid substrates from membranes and presenting them to their respective enzymes. They are derived from a common precursor protein, prosaposin, which is proteolytically cleaved to yield four homologous proteins (saposin A, B, C, and D), each with distinct but partially overlapping lipid and enzyme specificities., [UniProtKB, UniProtKB]; Saposins are specific low-molecular mass non-enzymatic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A ARSA (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases., [UniProtKB, UniProtKB]; The present findings indicate that PSAP and its receptors, GPR37 and GPR37L1, are expressed in the major salivary glands of rats and their immunoreactivities differ considerably with age and sex., [RefSeq, PubMed]; acts as an essential lysosomal cofactor that activates galactocerebrosidase (GALC, EC 3.2.1.46) by facilitating enzyme access to its membrane-embedded galactosylceramide substrate, the principal lipid component of myelin., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q62841;Q64190", "ec_number_list": [], "go_molecular_function": "GO:1905573 ganglioside GM1 binding;GO:0002020 protease binding;GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0046836 glycolipid transport;GO:0006664 glycolipid metabolic process;GO:0006886 intracellular protein transport;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P10960-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11762-1", "uniprot_id": [ { "id": "LEG1_RAT", "url": "https://www.uniprot.org/uniprot/P11762", "type": "external" } ], "mass": 14857.0, "length": 135, "protein_name": "Galectin-1", "gene_name": "Lgals1", "organism": "Rat", "refseq_name": "galectin-1", "refseq_ac": [ { "id": "NP_063969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_063969", "type": "external" } ], "gene_names_uniprotkb": "Lgals1", "gene_names_refseq": "Lgals1", "protein_names_uniprotkb": "Galectin-1; 14 kDa lectin; Beta-galactoside-binding lectin L-14-I; Gal-1; Galaptin; Lactose-binding lectin 1; Lectin galactoside-binding soluble 1; RL 14.5; S-Lac lectin 1", "protein_names_refseq": "14 kDa lectin; RL 14.5; S-Lac lectin 1; beta-galactoside-binding lectin L-14-I; gal-1; galaptin; galectin-1; lactose-binding lectin 1; lectin, galactose binding, soluble 1; lectin, galactoside-binding, soluble, 1", "tax_id": 10116, "disease": "lipoid nephrosis (Disease Ontology:DOID:10966); extrahepatic cholestasis (Disease Ontology:DOID:13619); B-cell lymphoma (Disease Ontology:DOID:707)", "pathway": " (rno:56646); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "20873803;2319298;27573167;30463690;3349058;37557976", "class_list": "", "function": "Dysregulated Gal-1 and Ca(V)1.2 alternative exon 9* might be attributed to the pathological processes of cardiac hypertrophy, and provides a potential anti-hypertrophic target in the heart., [RefSeq, PubMed]; Galectin-1 as a marker for microglia activation in the aging brain., [RefSeq, PubMed]; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69., [UniProtKB, UniProtKB]; Stress-induced Gal-1 immediately accumulates in the spleen and thymus, and may modulate the immune response through apoptosis by binding to CD45(+) lymphocytes in immune organs following physiological and/or psychological stress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0043236 laminin binding;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity;GO:0030395 lactose binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:1990724 galectin complex", "go_biological_process": "GO:0035900 response to isolation stress;GO:0043065 positive regulation of apoptotic process;GO:0071333 cellular response to glucose stimulus;GO:0006915 apoptotic process;GO:0031295 T cell costimulation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P11762-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12526-1", "uniprot_id": [ { "id": "MAS_RAT", "url": "https://www.uniprot.org/uniprot/P12526", "type": "external" } ], "mass": 37131.0, "length": 324, "protein_name": "Proto-oncogene Mas", "gene_name": "Mas1", "organism": "Rat", "refseq_name": "proto-oncogene Mas", "refseq_ac": [ { "id": "NP_036889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036889", "type": "external" } ], "gene_names_uniprotkb": "Mas1; Mas-1; Mas", "gene_names_refseq": "Mas1; Mgra; c-mas", "protein_names_uniprotkb": "Proto-oncogene Mas", "protein_names_refseq": "MAS proto-oncogene; MAS1 oncogene; Mas-related G protein-coupled receptor a; angiotensin-(1-7) receptor; proto-oncogene Mas", "tax_id": 10116, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); arrhythmogenic right ventricular dysplasia 10 (Disease Ontology:DOID:0110081); dilated cardiomyopathy 1BB (Disease Ontology:DOID:0110458); hypertension (Disease Ontology:DOID:10763); primary biliary cholangitis (Disease Ontology:DOID:12236); dilated cardiomyopathy (Disease Ontology:DOID:12930); glaucoma (Disease Ontology:DOID:1686); congestive heart failure (Disease Ontology:DOID:6000); chronic kidney disease (Disease Ontology:DOID:784); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (rno:25153)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18026570;2455902;32851948;33070664;34743271;35247425", "class_list": "", "function": "Aerobic training-mediated DNA hypermethylation of Agtr1a and Mas1 genes ameliorate mesenteric arterial function in spontaneously hypertensive rats., [RefSeq, PubMed]; Angiotensin-(1-7), Angiotensin-Converting Enzyme 2 and Mas Receptor in Rat Polycystic Ovaries., [RefSeq, PubMed]; G protein-coupled receptor MAS1 induces an inhibitory effect on myocardial infarction-induced myocardial injury., [RefSeq, PubMed]; G protein-coupled receptor that plays key roles in the renin-angiotensin system (RAS) specifically in the protective, counter-regulatory arm of the RAS. Receptor mainly stimulated by angiotensin 1-7, which is a bioactive metabolite of the angiotensin produced by ACE2. Activation promotes nitric oxide via PI3K/Akt-eNOS pathway. Modulates also the MAPK, ERK1/2, and NF-kappa-B signaling. Positive regulation of AGTR1 levels occurs through activation of the G proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. Acts as functional receptor for CXCL17 and induces chemotactic movement., [UniProtKB, UniProtKB, UniProtKB]; Mas Receptor Activation Contributes to the Improvement of Nitric Oxide Bioavailability and Vascular Remodeling During Chronic AT1R (Angiotensin Type-1 Receptor) Blockade in Experimental Hypertension., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0008528 G protein-coupled peptide receptor activity;GO:0042277 peptide binding;GO:0001595 angiotensin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007283 spermatogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P12526-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12928-1", "uniprot_id": [ { "id": "KPYR_RAT", "url": "https://www.uniprot.org/uniprot/P12928", "type": "external" } ], "mass": 62200.0, "length": 574, "protein_name": "Pyruvate kinase PKLR", "gene_name": "Pklr", "organism": "Rat", "refseq_name": "pyruvate kinase PKLR", "refseq_ac": [ { "id": "NP_036756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036756", "type": "external" } ], "gene_names_uniprotkb": "Pklr", "gene_names_refseq": "PK1; PKL; Pklg; Pklr", "protein_names_uniprotkb": "Pyruvate kinase PKLR; 2.7.1.40; L-PK; Pyruvate kinase isozymes L/R", "protein_names_refseq": "L-PK; pyruvate kinase PKLR; pyruvate kinase isozymes L/R; pyruvate kinase isozymes R/L; pyruvate kinase, liver and RBC; pyruvate kinase, liver and red blood cell", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); congenital nonspherocytic hemolytic anemia 2 (Disease Ontology:DOID:0111077); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); malaria (Disease Ontology:DOID:12365); Gaucher's disease (Disease Ontology:DOID:1926); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); hyperglycemia (Disease Ontology:DOID:4195); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:24651); (R-RNO-70171); (R-RNO-70268)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "21239437;22673903;22878931;3002799;3080337;31825824;3309348;3654663", "class_list": "", "function": "Data report that DNA hypermethylation is correlated with a decline in hepatic glucokinase (Gck) and L-type pyruvate kinase (LPK) expression in high-fat diet-induced obese rats as compared with the control diet group., [RefSeq, PubMed]; Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production., [RefSeq, PubMed]; Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis. Also produces the side product 2-phospholactate which can inhibit fructose-2,6-bisphosphate production. 2-phospholactate can be dephosphorylated by PGP which prevents the inhibition of fructose-2,6-bisphosphate production and allows glycolysis to occur., [UniProtKB, UniProtKB]; Studied the effect of the point mutations around this phosphorylation site on the catalytic properties of L-pyruvate kinase., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P04763;Q64618", "ec_number_list": [ { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0030955 potassium ion binding;GO:0004743 pyruvate kinase activity", "go_cellular_component": "GO:1902912 pyruvate kinase complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042866 pyruvate biosynthetic process;GO:0051707 response to other organism;GO:0007584 response to nutrient;GO:0032869 cellular response to insulin stimulus;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P12928-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13839-1", "uniprot_id": [ { "id": "SIAL_RAT", "url": "https://www.uniprot.org/uniprot/P13839", "type": "external" } ], "mass": 35251.0, "length": 320, "protein_name": "Integrin-binding sialoprotein", "gene_name": "Ibsp", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ibsp", "gene_names_refseq": "", "protein_names_uniprotkb": "Integrin-binding sialoprotein; BSP II; Bone sialoprotein 2; Bone sialoprotein II; Cell-binding sialoprotein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-216083)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "3198635", "class_list": "", "function": "Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes adhesion and migration of various cells via the alpha-V/beta-3 integrin receptor (ITGAV:ITGB3)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P97828", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0036094 small molecule binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031982 vesicle", "go_biological_process": "GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization;GO:0045785 positive regulation of cell adhesion;GO:0071363 cellular response to growth factor stimulus;GO:0001503 ossification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P13839-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15950-1", "uniprot_id": [ { "id": "KLK3_RAT", "url": "https://www.uniprot.org/uniprot/P15950", "type": "external" } ], "mass": 20986.0, "length": 188, "protein_name": "Glandular kallikrein-3, submandibular", "gene_name": "Klk3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Klk3; Klk-3", "gene_names_refseq": "", "protein_names_uniprotkb": "Glandular kallikrein-3, submandibular; 3.4.21.35; RSGK-50; S1 kallikrein; Tissue kallikrein; rGK-3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "2550051;2998455", "class_list": "", "function": "Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P15950-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16036-1", "uniprot_id": [ { "id": "S25A3_RAT", "url": "https://www.uniprot.org/uniprot/P16036", "type": "external" } ], "mass": 39445.0, "length": 356, "protein_name": "Solute carrier family 25 member 3", "gene_name": "Slc25a3; Tmpo", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc25a3; Tmpo; Phc; Slc25a3", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 25 member 3; PTP; Phosphate carrier protein, mitochondrial; Phosphate transport protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (rno:25359)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18667415;1985946;2250020;2670944;27213235;38843836", "class_list": "", "function": "Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment (By similarity). Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP (By similarity). Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly (By similarity). May also play a role in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:18667415)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0005315 phosphate transmembrane transporter activity;GO:0015317 phosphate:proton symporter activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005635 nuclear envelope;GO:0005694 chromosome", "go_biological_process": "GO:0035435 phosphate ion transmembrane transport;GO:1990547 mitochondrial phosphate ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P16036-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16975-1", "uniprot_id": [ { "id": "SPRC_RAT", "url": "https://www.uniprot.org/uniprot/P16975", "type": "external" } ], "mass": 34296.0, "length": 301, "protein_name": "SPARC", "gene_name": "Sparc", "organism": "Rat", "refseq_name": "SPARC precursor", "refseq_ac": [ { "id": "NP_036788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036788", "type": "external" } ], "gene_names_uniprotkb": "Sparc", "gene_names_refseq": "Sparc", "protein_names_uniprotkb": "SPARC; BM-40; Basement-membrane protein 40; ON; Osteonectin; Secreted protein acidic and rich in cysteine", "protein_names_refseq": "BM-40; ON; SPARC precursor; Secreted acidic cystein-rich glycoprotein (osteonectin); basement-membrane protein 40; osteonectin; secreted acidic cysteine rich glycoprotein; secreted protein acidic and rich in cysteine; secreted protein, acidic, cysteine-rich (osteonectin)", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); osteogenesis imperfecta type 17 (Disease Ontology:DOID:0110338); progressive osseous heteroplasia (Disease Ontology:DOID:0111535); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); diabetic angiopathy (Disease Ontology:DOID:11713); calcinosis (Disease Ontology:DOID:182); ovary epithelial cancer (Disease Ontology:DOID:2152); endometrial carcinoma (Disease Ontology:DOID:2871); cervix carcinoma (Disease Ontology:DOID:2893); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); renal cell carcinoma (Disease Ontology:DOID:4450); stomach carcinoma (Disease Ontology:DOID:5517); myocardial infarction (Disease Ontology:DOID:5844); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (rno:24791); (R-RNO-114608); (R-RNO-3000497)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "2322281;30424792;30560317;34876214;36241137;8660135;9541258", "class_list": "", "function": "Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data suggest that reversion-inducing-cysteine-rich protein with kazal motifs (Reck) and SPARC Glycoprotein (Sparc) seem to play a role during ovarian dynamics: Reck as a possible inhibitor and Sparc as an inducer of matrix metalloproteinases (Mmps). Publication Status: Online-Only, [RefSeq, PubMed]; Discoidin domain receptor 2 activation of p38 mitogen-activated protein kinase as an important pathway for osteonectin-regulating osteoblast mineralization. Publication Status: Online-Only, [RefSeq, PubMed]; Increased Sparc release from subchondral osteoblasts promotes articular chondrocyte degeneration under estrogen withdrawal., [RefSeq, PubMed]; MiR-29b-3p plays an important role in the progression of heart failure through targeting SPARC and regulating TGFbeta1/Smad3 pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08953;Q6GSZ4", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005518 collagen binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0048752 semicircular canal morphogenesis;GO:0007507 heart development;GO:0010288 response to lead ion;GO:0032496 response to lipopolysaccharide;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P16975-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17105-1", "uniprot_id": [ { "id": "IP3KA_RAT", "url": "https://www.uniprot.org/uniprot/P17105", "type": "external" } ], "mass": 50871.0, "length": 459, "protein_name": "Inositol-trisphosphate 3-kinase A", "gene_name": "Itpka", "organism": "Rat", "refseq_name": "inositol-trisphosphate 3-kinase A", "refseq_ac": [ { "id": "NP_112307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112307", "type": "external" } ], "gene_names_uniprotkb": "Itpka", "gene_names_refseq": "Itpka", "protein_names_uniprotkb": "Inositol-trisphosphate 3-kinase A; 2.7.1.127; IP3 3-kinase A; IP3K A; Inositol 1,4,5-trisphosphate 3-kinase A; InsP 3-kinase A", "protein_names_refseq": "IP3 3-kinase A; IP3K A; inositol 1,4,5-triphosphate 3-kinase; inositol 1,4,5-trisphosphate 3-kinase A; inositol 145-triphosphate 3-kinase; inositol-trisphosphate 3-kinase A; insP 3-kinase A", "tax_id": 10116, "disease": "", "pathway": " (rno:81677); (R-RNO-1855204)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12527368;15350215;15537642;19846664;2157285;2176078;22384237;22389500;22673903;7646431", "class_list": "", "function": "Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis., [UniProtKB, PubMed]; Data show that protein kinse A (PKA) phosphorylated Ser-119 within inositol 1,4,5-trisphosphate 3-kinase A (IP(3)K-A), leading to a significant reduction of microtubule binding affinity., [RefSeq, PubMed]; IP3 3-kinase opposes NGF driven neurite outgrowth, [RefSeq, PubMed]; The large majority of InsP3R3 channels free to diffuse throughout the endoplasmic reticulum, at rates that are comparable with those measured for other polytopic ER integral membrane proteins, [RefSeq, PubMed]; These results suggest that oscillations in InsP(3) concentration due to Ca(2+)-stimulated InsP(3) catabolism do not play a major role for the oscillations in Ca(2+) concentration., [RefSeq, PubMed]; These results suggest that, in addition to its ability to regulate intracellular Ca(2+) via Ins(1,4,5)P(3) metabolism, ITPKA regulates structural plasticity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.127", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.127", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" } ], "go_molecular_function": "GO:0000828 inositol hexakisphosphate kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0031267 small GTPase binding;GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0006020 inositol metabolic process;GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0051592 response to calcium ion;GO:0048167 regulation of synaptic plasticity;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P17105-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17559-1", "uniprot_id": [ { "id": "UTER_RAT", "url": "https://www.uniprot.org/uniprot/P17559", "type": "external" } ], "mass": 10449.0, "length": 96, "protein_name": "Uteroglobin", "gene_name": "Scgb1a1", "organism": "Rat", "refseq_name": "uteroglobin precursor", "refseq_ac": [ { "id": "NP_037183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037183", "type": "external" } ], "gene_names_uniprotkb": "Scgb1a1; Cc10; Ugb; Utg", "gene_names_refseq": "CC10; CC16; CCSP; PCBB; Scgb1a1; Ugb", "protein_names_uniprotkb": "Uteroglobin; CC10; CCPBP; Club cell phospholipid-binding protein; Club cells 10 kDa secretory protein; PCB-binding protein; Secretoglobin family 1A member 1", "protein_names_refseq": "CCPBP; PCB-binding protein; Uteroglobin (club cell secretory protein); club cell 10 kDa secretory protein; club cell phospholipid-binding protein; club cell protein 16; club cells 10 kDa secretory protein; club secretory protein-16; secretoglobin, family 1A, member 1 (uteroglobin); uteroglobin precursor", "tax_id": 10116, "disease": "otitis media (Disease Ontology:DOID:10754); meconium aspiration syndrome (Disease Ontology:DOID:11049); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); pulmonary fibrosis (Disease Ontology:DOID:3770); pulmonary eosinophilia (Disease Ontology:DOID:9498)", "pathway": " (rno:25575)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1560460;2115524;2349092;7583672", "class_list": "", "function": "Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019834 phospholipase A2 inhibitor activity;GO:0097160 polychlorinated biphenyl binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0030141 secretory granule", "go_biological_process": "GO:0034021 response to silicon dioxide;GO:0032714 negative regulation of interleukin-5 production;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P17559-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17764-1", "uniprot_id": [ { "id": "THIL_RAT", "url": "https://www.uniprot.org/uniprot/P17764", "type": "external" } ], "mass": 44695.0, "length": 424, "protein_name": "Acetyl-CoA acetyltransferase, mitochondrial", "gene_name": "Acat1", "organism": "Rat", "refseq_name": "acetyl-CoA acetyltransferase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_058771", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058771", "type": "external" } ], "gene_names_uniprotkb": "Acat1", "gene_names_refseq": "Acat1; RATACAL", "protein_names_uniprotkb": "Acetyl-CoA acetyltransferase, mitochondrial; 2.3.1.9; Acetoacetyl-CoA thiolase", "protein_names_refseq": "acetoacetyl-CoA thiolase; acetyl-Co A acetyltransferase 1 mitochondrial; acetyl-CoA acetyltransferase, mitochondrial precursor; acetyl-CoA acetyltransferase, mitochondrial; acetyl-coenzyme A acetyltransferase 1", "tax_id": 10116, "disease": "nephrotic syndrome (Disease Ontology:DOID:1184); beta-ketothiolase deficiency (Disease Ontology:DOID:14723); arteriosclerosis (Disease Ontology:DOID:2349); carbohydrate metabolic disorder (Disease Ontology:DOID:2978); end stage renal disease (Disease Ontology:DOID:783); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25014); (R-RNO-70895); (R-RNO-77108); (R-RNO-77111); (R-RNO-9837999); (R-RNO-9854311)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "2478525;25778834;27213235;34502162;38843836", "class_list": "", "function": "Rats treated with KD (EXP2) showed a significant down-regulated expression of ZnT-3, MT-3, ApoE, clusterin, and ACAT-1 in hippocampus, [RefSeq, PubMed]; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0120225 coenzyme A binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0030955 potassium ion binding;GO:0034736 cholesterol O-acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0001889 liver development;GO:0006635 fatty acid beta-oxidation;GO:0042594 response to starvation;GO:0060612 adipose tissue development;GO:0006085 acetyl-CoA biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P17764-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18331-1", "uniprot_id": [ { "id": "INHBA_RAT", "url": "https://www.uniprot.org/uniprot/P18331", "type": "external" } ], "mass": 47406.0, "length": 424, "protein_name": "Inhibin beta A chain", "gene_name": "Inhba", "organism": "Rat", "refseq_name": "inhibin beta A chain preproprotein", "refseq_ac": [ { "id": "NP_058824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058824", "type": "external" } ], "gene_names_uniprotkb": "Inhba", "gene_names_refseq": "Inhba", "protein_names_uniprotkb": "Inhibin beta A chain; Activin beta-A chain", "protein_names_refseq": "activin A; activin beta-A chain; inhibin beta A chain preproprotein; inhibin beta A chain; inhibin beta A subunit; inhibin beta-A", "tax_id": 10116, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); gestational diabetes (Disease Ontology:DOID:11714); prolapse of female genital organ (Disease Ontology:DOID:1284); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:29200); (R-RNO-1502540); (R-RNO-201451); (R-RNO-209822); (R-RNO-2473224); (R-RNO-9839406)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "18992787;3092356;3153478;32133888", "class_list": "", "function": "Activin A is a homodimer of INHBA that plays a role in several essential biological processes including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis. Signals through type I (such as ACVR1B or ACVR1C) and type II receptors (such as ACVR2A, ACVR2B or BMPR2) which, upon ligand binding, phosphorylate SMAD2 and SMAD3 intracellular signaling mediators that form a complex with SMAD4, translocate to the nucleus and modulate gene expression. Can also activate alternative non-canonical intracellular signaling pathways including the p38 MAPK, extracellular signal-regulated kinases 1/2 (ERK1/2) and c-Jun N-terminal kinases (JNKs) to modulate cell migration and differentiation. Alternatively, promotes osteoblastic differentiation via ACVRL1-SMAD1/5/9 pathway. In addition, can engage the type I receptor ACVR1 to form an ACVR1-activin A-type II receptor non-signaling complex (NSC) that renders receptors unavailable for engagement with BMPs, hence resulting in an apparent inhibition of ACVR1-mediated BMP signaling., [UniProtKB, UniProtKB]; Activin A overexpression promotes rat follicular development through SCF-kit-mediated cell signals., [RefSeq, PubMed]; Inhibin A is a dimer of alpha/INHA and beta-A/INHBA that functions as a feedback regulator in the hypothalamic-pituitary-gonadal (HPG) axis. Inhibits the secretion of FSH from the anterior pituitary gland by acting on pituitary gonadotrope cells. Antagonizes activin A by binding to the proteoglycan, betaglycan, and forming a stable complex with and, thereby, sequestering type II activin receptors while excluding type I receptor., [UniProtKB, UniProtKB]; Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070699 type II activin receptor binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0043509 activin A complex;GO:0043512 inhibin A complex;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0046880 regulation of follicle-stimulating hormone secretion;GO:0060279 positive regulation of ovulation;GO:0001934 positive regulation of protein phosphorylation;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P18331-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18614-1", "uniprot_id": [ { "id": "ITA1_RAT", "url": "https://www.uniprot.org/uniprot/P18614", "type": "external" } ], "mass": 130809.0, "length": 1180, "protein_name": "Integrin alpha-1", "gene_name": "Itga1", "organism": "Rat", "refseq_name": "integrin alpha-1 precursor", "refseq_ac": [ { "id": "NP_112256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112256", "type": "external" } ], "gene_names_uniprotkb": "Itga1", "gene_names_refseq": "Itga1", "protein_names_uniprotkb": "Integrin alpha-1; CD49 antigen-like family member A; Laminin and collagen receptor; VLA-1", "protein_names_refseq": "CD49 antigen-like family member A; VLA-1; integrin alpha-1 precursor; integrin alpha-1; laminin and collagen receptor", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (rno:25118); (R-RNO-216083); (R-RNO-445355)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10386626;21454685;2380249;24090084;26520903;27108411;27484337;29393594", "class_list": "", "function": "Alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects on vascular smooth muscle cell proliferation/migration., [RefSeq, PubMed]; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Periodic mechanical stress induced ECM expression and the migration of NP cells via upregulating the expression of integrin alpha1 and the phosphorylation of downstream PLCgamma1. These findings provide novel information to aid the understanding of the pathogenesis and development of IDD., [RefSeq, PubMed]; This study shows that E2 protects against apoptosis in a time-dependent manner, and alpha1 integrin-mediated adhesion to collagen II is essential for estrogen-dependent anti-apoptosis in rat annulus fibrosus cells in vitro. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 22, "predicted_n_glycosites": 22, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 24, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0046872 metal ion binding;GO:0005518 collagen binding;GO:0019903 protein phosphatase binding;GO:0019211 phosphatase activator activity", "go_cellular_component": "GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0043204 perikaryon;GO:0045178 basal part of cell;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0042311 vasodilation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P18614-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18666-1", "uniprot_id": [ { "id": "ML12B_RAT", "url": "https://www.uniprot.org/uniprot/P18666", "type": "external" } ], "mass": 19838.0, "length": 172, "protein_name": "Myosin regulatory light chain 12B", "gene_name": "Myl12b", "organism": "Rat", "refseq_name": "myosin regulatory light chain 12B", "refseq_ac": [ { "id": "NP_059039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059039", "type": "external" } ], "gene_names_uniprotkb": "Myl12b; Mrlc2; Mrlcb; Mylc2b", "gene_names_refseq": "MLC-2; MLC20; Mrlc2; Mrlcb; Myl12b; Mylc2b", "protein_names_uniprotkb": "Myosin regulatory light chain 12B; MLC-2; MLC20; Myosin RLC-B; Myosin regulatory light chain 2-B, smooth muscle isoform; Myosin regulatory light chain 20 kDa; Myosin regulatory light chain MRLC2", "protein_names_refseq": "myosin RLC-B; myosin light chain, regulatory B; myosin regulatory light chain 12B; myosin regulatory light chain 20 kDa; myosin regulatory light chain MRLC2; myosin regulatory light chain-B; myosin, light chain 12B, regulatory", "tax_id": 10116, "disease": "", "pathway": " (rno:50685); (R-RNO-445355)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11384979;18835913;22661704;2391362;27233767", "class_list": "", "function": "Findings conclude that phosphorylation at Thr(18) decreases the rates of LC(20) dephosphorylation and smooth muscle relaxation compared with LC(20) phosphorylated exclusively at Ser(19)., [RefSeq, PubMed]; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion., [UniProtKB, PubMed]; Phosphorylation of myosin regulatory light chain (RLC) increased and remained elevated post-MI, while phosphorylation of myosin binding protein-C (MyBP-C) was initially depressed but then increased as the hearts became decompensated., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P9V4", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0051020 GTPase binding;GO:0032036 myosin heavy chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005903 brush border;GO:0005938 cell cortex;GO:0045177 apical part of cell;GO:0001725 stress fiber", "go_biological_process": "GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P18666-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18897-1", "uniprot_id": [ { "id": "SMR2_RAT", "url": "https://www.uniprot.org/uniprot/P18897", "type": "external" } ], "mass": 15485.0, "length": 137, "protein_name": "SMR2 protein", "gene_name": "Smr2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Smr2", "gene_names_refseq": "", "protein_names_uniprotkb": "SMR2 protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2355016", "class_list": "", "function": "Unknown, male-specific function., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P18897-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20720-1", "uniprot_id": [ { "id": "UD12_RAT", "url": "https://www.uniprot.org/uniprot/P20720", "type": "external" } ], "mass": 60045.0, "length": 533, "protein_name": "UDP-glucuronosyltransferase 1-2", "gene_name": "Ugt1a2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ugt1a2; Ugt1", "gene_names_refseq": "", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 1-2; 2.4.1.17; B2; Bilirubin-specific UDPGT; UDP-glucuronosyltransferase 1A2; UDPGT 1-2; UGT1*2; UGT1-02; UGT1.2; UGT1A2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-156588); (R-RNO-189483); (R-RNO-9749641); (R-RNO-9754706); (R-RNO-9757110)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "2112380;7608130", "class_list": "glycogene;glycosyltransferase", "function": "UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q64636", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" } ], "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0001889 liver development;GO:0006805 xenobiotic metabolic process;GO:0016125 sterol metabolic process;GO:0031100 animal organ regeneration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P20720-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20761-1", "uniprot_id": [ { "id": "IGG2B_RAT", "url": "https://www.uniprot.org/uniprot/P20761", "type": "external" } ], "mass": 36497.0, "length": 333, "protein_name": "Ig gamma-2B chain C region", "gene_name": "Igh-1a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Igh-1a", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig gamma-2B chain C region; Immunoglobulin heavy chain 1a", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "3016742;3149946;34502162", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0003823 antigen binding", "go_cellular_component": "GO:0042571 immunoglobulin complex, circulating", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P20761-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20766-1", "uniprot_id": [ { "id": "LAC1_RAT", "url": "https://www.uniprot.org/uniprot/P20766", "type": "external" } ], "mass": 11565.0, "length": 104, "protein_name": "Ig lambda-1 chain C region", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig lambda-1 chain C region", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3114047", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0019815 B cell receptor complex;GO:0071735 IgG immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P20766-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20767-1", "uniprot_id": [ { "id": "LAC2_RAT", "url": "https://www.uniprot.org/uniprot/P20767", "type": "external" } ], "mass": 11318.0, "length": 104, "protein_name": "Ig lambda-2 chain C region", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig lambda-2 chain C region", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "3114047;34502162", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0071735 IgG immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P20767-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21581-1", "uniprot_id": [ { "id": "SCF_RAT", "url": "https://www.uniprot.org/uniprot/P21581", "type": "external" } ], "mass": 30712.0, "length": 273, "protein_name": "Kit ligand", "gene_name": "Kitlg", "organism": "Rat", "refseq_name": "kit ligand isoform 1 precursor", "refseq_ac": [ { "id": "NP_068615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068615", "type": "external" } ], "gene_names_uniprotkb": "Kitlg; Kitl; Mgf", "gene_names_refseq": "Kitlg; Kitl; Mgf; SCF", "protein_names_uniprotkb": "Kit ligand; Hematopoietic growth factor KL; MGF; Mast cell growth factor; SCF; Stem cell factor; c-Kit ligand", "protein_names_refseq": "C-kit ligand; hematopoietic growth factor KL; kit ligand isoform 1 precursor; mast cell growth factor; steel factor/kit ligand; stem cell factor KL-1", "tax_id": 10116, "disease": "dextro-looped transposition of the great arteries (Disease Ontology:DOID:0060770); autosomal dominant nonsyndromic deafness 69 (Disease Ontology:DOID:0110590); familial progressive hyperpigmentation with or without hypopigmentation (Disease Ontology:DOID:0111373); pigmentation disease (Disease Ontology:DOID:10123); neurodegenerative disease (Disease Ontology:DOID:1289); Waardenburg syndrome (Disease Ontology:DOID:9258)", "pathway": " (rno:60427); (R-RNO-1257604); (R-RNO-1433557); (R-RNO-1433559); (R-RNO-5673001); (R-RNO-6811558); (R-RNO-9856649)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "1708771;2208278;2208279;27707610;28801138;30142893", "class_list": "", "function": "It was concluded that the exposure of cadimium on newborn rats ovaries could inhibit follicle development. SCF/c-kit system might mediate follicle development damage caused by cadmium, which is associated with DNA hypomethylation of SCF/c-kit promoter region may be worthy of further study., [RefSeq, PubMed]; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins., [UniProtKB, UniProtKB, UniProtKB]; The SCF/c-KIT system is aberrantly expressed in varicocele(VC) testis, which could be involved in male infertility caused by VC., [RefSeq, PubMed]; The data suggest that microtubule acetylation upregulates KL1 and induces more aneuploidy if tau is deficient. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 3, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9QWZ4;Q9Z2E7", "ec_number_list": [], "go_molecular_function": "GO:0005173 stem cell factor receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0008584 male gonad development;GO:0001541 ovarian follicle development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P21581-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21913-1", "uniprot_id": [ { "id": "SDHB_RAT", "url": "https://www.uniprot.org/uniprot/P21913", "type": "external" } ], "mass": 31830.0, "length": 282, "protein_name": "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial", "gene_name": "Sdhb", "organism": "Rat", "refseq_name": "succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001094009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094009", "type": "external" } ], "gene_names_uniprotkb": "Sdhb; Sdh1", "gene_names_refseq": "Sdhb", "protein_names_uniprotkb": "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; 1.1.5.-; 1.3.5.1; Ip; Iron-sulfur subunit of complex II; Malate dehydrogenase [quinone] iron-sulfur subunit", "protein_names_refseq": "ip; iron-sulfur subunit of complex II; malate dehydrogenase [quinone] iron-sulfur subunit; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; succinate dehydrogenase complex, subunit B, iron sulfur (Ip)", "tax_id": 10116, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); paraganglioma (Disease Ontology:DOID:0050773); mitochondrial complex II deficiency (Disease Ontology:DOID:0060537); pheochromocytoma/paraganglioma syndrome 4 (Disease Ontology:DOID:0061219); Carney-Stratakis syndrome (Disease Ontology:DOID:0080533); mitochondrial encephalomyopathy (Disease Ontology:DOID:890); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (rno:298596); (R-RNO-71403); (R-RNO-9854311)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "16751257;2494655;26446791;27213235;34502162;36005845", "class_list": "", "function": "Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)., [UniProtKB, UniProtKB]; Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; [Molecular and biochemical studies of succinate dehydrogenase in rat liver under conditions of alloxan diabetes].', trans 'Molekuliarnye i biokhimicheskie issledovaniia suktsinatdegidrogenazy v pecheni krys v usloviiakh alloksanovogo diabeta., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B0BMZ2;Q0QEZ3", "ec_number_list": [ { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.3.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.5.1", "type": "external" }, { "id": "1.1.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.5.-", "type": "external" }, { "id": "2.8.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.7", "type": "external" } ], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0051538 3 iron, 4 sulfur cluster binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane;GO:0045273 respiratory chain complex II (succinate dehydrogenase)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0022904 respiratory electron transport chain;GO:0006105 succinate metabolic process;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P21913-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22789-1", "uniprot_id": [ { "id": "ST2A6_RAT", "url": "https://www.uniprot.org/uniprot/P22789", "type": "external" } ], "mass": 33252.0, "length": 284, "protein_name": "Sulfotransferase 2A6", "gene_name": "Sult2a6", "organism": "Rat", "refseq_name": "sulfotransferase 2A6", "refseq_ac": [ { "id": "NP_036827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036827", "type": "external" } ], "gene_names_uniprotkb": "Sult2a6; Smp2a; St2a2", "gene_names_refseq": "BAST I; RATSMP2A; RATSMP2B; ST-41; ST2A6; Smp2a; St2a2; Sult2a4l1; Sult2a6; Sult2al1", "protein_names_uniprotkb": "Sulfotransferase 2A6; 2.8.2.14; 2.8.2.2; AD-ST; Androsterone-sulfating sulfotransferase; BAST I; Bile acid:3'phosphoadenosine-5'phosphosulfate:sulfotransferase I; Hydroxysteroid sulfotransferase A; ST-40; ST-41; ST2A6; STa; Senescence marker protein 2A", "protein_names_refseq": "AD-ST; ST-40; STA; Sult2al1, sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring-like 1; alcohol sulfotransferase A; androsterone-sulfating sulfotransferase; bile acid:3'phosphoadenosine-5'phosphosulfate:sulfotransferase I; hydroxysteroid sulfotransferase A; senescence marker protein 2A gene, exons 1 and 2; sulfotransferase 2A2; sulfotransferase 2A6; sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 4-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:24902); (R-RNO-156584); (R-RNO-9753281)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "2113604;2302387;2306259;2754334;8033248;8352748", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of the hydroxyl group of hydroxysteroids and bile acids (PubMed:2754334). Prefered substrates are dehydroepiandrosterone (DHEA, also known as 3beta-hydroxyandrost-5-en-17-one) and 3beta-hydroxy-5-cholenoate, but can also catalyze deoxycholate and its conjugates, and lithocholate conjugates, in vitro (PubMed:2754334)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63551", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.14", "type": "external" }, { "id": "2.8.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.2", "type": "external" }, { "id": "2.8.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.1", "type": "external" }, { "id": "2.8.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.4", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0004027 alcohol sulfotransferase activity;GO:0047704 bile-salt sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051923 sulfation;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P22789-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24155-1", "uniprot_id": [ { "id": "THOP1_RAT", "url": "https://www.uniprot.org/uniprot/P24155", "type": "external" } ], "mass": 78385.0, "length": 687, "protein_name": "Thimet oligopeptidase", "gene_name": "Thop1", "organism": "Rat", "refseq_name": "thimet oligopeptidase", "refseq_ac": [ { "id": "NP_742072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742072", "type": "external" } ], "gene_names_uniprotkb": "Thop1", "gene_names_refseq": "EP24.15; Thop1", "protein_names_uniprotkb": "Thimet oligopeptidase; 3.4.24.15; Endo-oligopeptidase A; Endopeptidase 24.15; PZ-peptidase; Soluble metallo-endopeptidase", "protein_names_refseq": "PZ-peptidase; endo-oligopeptidase A; endopeptidase 24.15; metalloendopeptidase; soluble metallo-endopeptidase; thimet oligopeptidase", "tax_id": 10116, "disease": "", "pathway": " (rno:64517); (R-RNO-983168)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12500972;18077343;18571100;18683930;22387539;2261476;24041943;26653570;8216239", "class_list": "", "function": "Coincubation of Kiss1 and EP24.15 demonstrated multiple cleavages of the peptide in vitro. immunohistochemistry indicated coexpression of EP24.15 and Kiss1, implicating that the regulation of Kiss1 by EP24.15 could occur in vivo., [RefSeq, PubMed]; Increase in THOP1 expression might be part of a compensatory defense mechanism of the brain against an increased Abeta load, [RefSeq, PubMed]; Involved in the metabolism of neuropeptides under 20 amino acid residues long (PubMed:2261476). Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (By similarity). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (PubMed:12500972, PubMed:18077343)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; TOP changes in the brain could play important role in the balance of neuropeptide level correlated with cocaine effects., [RefSeq, PubMed]; We show that Ang-(1-7) is the main metabolite of angiotensin I in rat hippocampi, and, strikingly, that thimet oligopeptidase is the main enzyme involved in the generation of Ang-(1-7)., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q66HS4", "ec_number_list": [ { "id": "3.4.24.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.15", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0042277 peptide binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0035556 intracellular signal transduction;GO:0043171 peptide catabolic process;GO:0006518 peptide metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P24155-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26260-1", "uniprot_id": [ { "id": "SDC1_RAT", "url": "https://www.uniprot.org/uniprot/P26260", "type": "external" } ], "mass": 33214.0, "length": 313, "protein_name": "Syndecan-1", "gene_name": "Sdc1", "organism": "Rat", "refseq_name": "syndecan-1 precursor", "refseq_ac": [ { "id": "NP_037158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037158", "type": "external" } ], "gene_names_uniprotkb": "Sdc1; Synd1", "gene_names_refseq": "HSPG; SYNDECA; Sdc1; Synd1; Syndecan", "protein_names_uniprotkb": "Syndecan-1; SYND1", "protein_names_refseq": "syndecan-1 precursor", "tax_id": 10116, "disease": "familial hyperlipidemia (Disease Ontology:DOID:1168); lung adenocarcinoma (Disease Ontology:DOID:3910); hyperglycemia (Disease Ontology:DOID:4195); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); Hodgkin's lymphoma (Disease Ontology:DOID:8567); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25216); (R-RNO-1971475); (R-RNO-2022928); (R-RNO-2024096); (R-RNO-3000170); (R-RNO-449836); (R-RNO-975634); (R-RNO-9769739)", "pathway_count": 8, "publication_count": 8, "publication_id_list": "1537865;1639809;25972509;27037369;27075925;33378064;8495865;9089390", "class_list": "", "function": "Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (By similarity). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Down-regulation of Syndecan-1 could inhibit VEGF-VEGFR-2 signaling through regulating internalization of VEGFR-2., [RefSeq, PubMed]; Expression of syndecan-1, PKC and VEGF in rats with acute kidney injury and correlation between syndecan-1 and renal function., [RefSeq, PubMed]; Expression upregulated two months after renal transplantation, [RefSeq, PubMed]; Plasma syndecan-1 and heparan sulfate correlate with microvascular glycocalyx degradation in hemorrhaged rats after different resuscitation fluids., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 1, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0050840 extracellular matrix binding;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0007267 cell-cell signaling;GO:0016477 cell migration;GO:0051592 response to calcium ion;GO:0042542 response to hydrogen peroxide", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P26260-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27158-1", "uniprot_id": [ { "id": "KITH_RAT", "url": "https://www.uniprot.org/uniprot/P27158", "type": "external" } ], "mass": 13511.0, "length": 121, "protein_name": "Thymidine kinase, cytosolic", "gene_name": "Tk1", "organism": "Rat", "refseq_name": "thymidine kinase, cytosolic", "refseq_ac": [ { "id": "NP_434687", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_434687", "type": "external" } ], "gene_names_uniprotkb": "Tk1; Tk-1", "gene_names_refseq": "Tk1; Tk", "protein_names_uniprotkb": "Thymidine kinase, cytosolic; 2.7.1.21", "protein_names_refseq": "thymidine kinase 1, soluble; thymidine kinase, cytosolic", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612); cervix carcinoma (Disease Ontology:DOID:2893); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (rno:24834)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1777676;20544526;22673903;3479791", "class_list": "", "function": "A cytosolic form of TK2 was identified in all tested tissues in addition to mitochondrial TK2. TK1 was detected in liver and spleen cytosolic extracts while dCK was found in liver, spleen and lung cytosolic extracts., [RefSeq, PubMed]; Cell-cycle-regulated enzyme of importance in nucleotide metabolism. Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate. Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6LAG4", "ec_number_list": [ { "id": "2.7.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.21", "type": "external" }, { "id": "2.7.1.74", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.74", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0004797 thymidine kinase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0046105 thymidine biosynthetic process;GO:0046104 thymidine metabolic process;GO:0001889 liver development;GO:0051289 protein homotetramerization;GO:0031667 response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P27158-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27615-1", "uniprot_id": [ { "id": "SCRB2_RAT", "url": "https://www.uniprot.org/uniprot/P27615", "type": "external" } ], "mass": 54091.0, "length": 478, "protein_name": "Lysosome membrane protein 2", "gene_name": "Scarb2", "organism": "Rat", "refseq_name": "lysosome membrane protein 2", "refseq_ac": [ { "id": "NP_446453", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446453", "type": "external" } ], "gene_names_uniprotkb": "Scarb2; Cd36l2; Limpii", "gene_names_refseq": "Cd36l2; LGP85; LimpII; Scarb2", "protein_names_uniprotkb": "Lysosome membrane protein 2; 85 kDa lysosomal membrane sialoglycoprotein; CD36 antigen-like 2; LGP85; LIMP II; Lysosome membrane protein II; Scavenger receptor class B member 2", "protein_names_refseq": "85 kDa lysosomal membrane sialoglycoprotein; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2; CD36 antigen-like 2; LIMP II; lysosome membrane protein 2; lysosome membrane protein II", "tax_id": 10116, "disease": "progressive myoclonus epilepsy 4 (Disease Ontology:DOID:0111444); progressive myoclonus epilepsy (Disease Ontology:DOID:891)", "pathway": " (rno:117106); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1039/D0MO00044B;16138903;1715871;1859403;24090084;32007273;33010890;34106099", "class_list": "", "function": "Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting., [UniProtKB, UniProtKB]; Involvement of lysosomal integral membrane protein-2 in the activation of autophagy., [RefSeq, PubMed]; Lysosomal integral membrane protein LGP85 (LIMP-2) is ubiquitinated at the N-terminal cytoplasmic domain., [RefSeq, PubMed]; These results indicate the involvement of distinct domains of LGP85 in the targeting to, and biogenesis and maintenance of, endosomal/lysosomal compartments., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 2, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0051087 protein-folding chaperone binding;GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0030666 endocytic vesicle membrane;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0006914 autophagy;GO:0006898 receptor-mediated endocytosis;GO:0006622 protein targeting to lysosome;GO:0015917 aminophospholipid transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P27615-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28570-1", "uniprot_id": [ { "id": "SC6A8_RAT", "url": "https://www.uniprot.org/uniprot/P28570", "type": "external" } ], "mass": 70632.0, "length": 635, "protein_name": "Sodium- and chloride-dependent creatine transporter 1", "gene_name": "Slc6a8", "organism": "Rat", "refseq_name": "sodium- and chloride-dependent creatine transporter 1", "refseq_ac": [ { "id": "NP_059044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059044", "type": "external" } ], "gene_names_uniprotkb": "Slc6a8", "gene_names_refseq": "CHOT1; CHT1; CRT; CT1; Slc6a8", "protein_names_uniprotkb": "Sodium- and chloride-dependent creatine transporter 1; CHOT1; CT1; Creatine transporter 1; Solute carrier family 6 member 8", "protein_names_refseq": "choline transporter; creatine transporter 1; sodium- and chloride-dependent creatine transporter 1; solute carrier family 6 (neurotransmitter transporter), member 8; solute carrier family 6 (neurotransmitter transporter, creatine), member 8", "tax_id": 10116, "disease": "cerebral creatine deficiency syndrome 1 (Disease Ontology:DOID:0050800); intellectual disability (Disease Ontology:DOID:1059); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (rno:50690); (R-RNO-71288)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11904763;12433955;15702372;1633856;23824558;27941337;32115505;33452333;8297374", "class_list": "", "function": "A new rat model of creatine transporter deficiency reveals behavioral disorder and altered brain metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; CXCL12 contributes to cholinergic gene expression via Akt signaling pathway., [RefSeq, PubMed]; Creatine:sodium symporter which mediates the uptake of creatine (PubMed:12433955, PubMed:15702372, PubMed:32115505, PubMed:8297374). Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Creatine:sodium symporter which mediates the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier., [UniProtKB, UniProtKB, UniProtKB]; Data show that choline transporter-1 is restricted to motoneurons and absent from the non-neuronal ACh-synthesizing elements, and is enriched at neuro-neuronal and neuro-muscular synapses., [RefSeq, PubMed]; TP is expressed at high levels in human GBM tumors and shRNA knockdown of TP in U87 GBM cells results in a significant increase in cellular GCL enzymatic activity, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity;GO:0015220 choline transmembrane transporter activity;GO:0005309 creatine:sodium symporter activity;GO:0005308 creatine transmembrane transporter activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0030163 protein catabolic process;GO:1990403 embryonic brain development;GO:0015881 creatine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P28570-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29457-1", "uniprot_id": [ { "id": "SERPH_RAT", "url": "https://www.uniprot.org/uniprot/P29457", "type": "external" } ], "mass": 46518.0, "length": 417, "protein_name": "Serpin H1", "gene_name": "Serpinh1", "organism": "Rat", "refseq_name": "serpin H1 precursor", "refseq_ac": [ { "id": "NP_058869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058869", "type": "external" } ], "gene_names_uniprotkb": "Serpinh1; Cbp1; Hsp47", "gene_names_refseq": "Cbp2; HSP47; Serpinh1; Serpinh2", "protein_names_uniprotkb": "Serpin H1; 47 kDa heat shock protein; Collagen-binding protein; Colligin; GP46", "protein_names_refseq": "47 kDa heat shock protein; GP46; collagen binding protein 2; collagen-binding protein; colligin; serine (or cysteine) peptidase inhibitor, clade H, member 1; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2; serine (or cysteine) proteinase inhibitor, clade H, member 1; serine proteinase inhibitor, clade H (heat shock protein 47), member 1; serpin H1 precursor; serpin H1; serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); serpin peptidase inhibitor, clade H, member 1", "tax_id": 10116, "disease": "osteogenesis imperfecta type 10 (Disease Ontology:DOID:0110346); preterm premature rupture of the membranes (Disease Ontology:DOID:0111144); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (rno:29345); (R-RNO-1650814)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1654327;2158279;37724035;38843836;38963323", "class_list": "", "function": "Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen., [UniProtKB]; Hsp47 promotes biogenesis of multi-subunit neuroreceptors in the endoplasmic reticulum. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of heat shock protein 47 suppressed collagen production in Tenon's capsule fibroblasts., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0051082 unfolded protein binding;GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0045121 membrane raft", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0051604 protein maturation;GO:0032964 collagen biosynthetic process;GO:0003433 chondrocyte development involved in endochondral bone morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P29457-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30937-1", "uniprot_id": [ { "id": "SSR4_RAT", "url": "https://www.uniprot.org/uniprot/P30937", "type": "external" } ], "mass": 42088.0, "length": 384, "protein_name": "Somatostatin receptor type 4", "gene_name": "Sstr4", "organism": "Rat", "refseq_name": "somatostatin receptor type 4", "refseq_ac": [ { "id": "NP_037168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037168", "type": "external" } ], "gene_names_uniprotkb": "Sstr4", "gene_names_refseq": "Smstr4; Sstr4", "protein_names_uniprotkb": "Somatostatin receptor type 4; SS-4-R; SS4-R; SS4R", "protein_names_refseq": "SS-4-R; SS4-R; SS4R; Somatostatin receptor subtype 4 Rattus norvegicus Sprague-Dawley major hippocampal somatostatin receptor (SSTR4) mRNA; somatostatin receptor type 4", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (rno:25555); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "1360663;22098068;23233668;24769416;25926390;30291955;8175684", "class_list": "", "function": "Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4, [RefSeq, PubMed]; All SSTR1-5 proteins were observed at embryonal day 10 and increased with time in major structures, but the localization varied between the different subtypes. SSTR3-4 was co-localized with insulin and pancreatic polypeptide., [RefSeq, PubMed]; Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade., [UniProtKB]; Somatostatin stimulates the migration of hepatic oval cells within injured liver through SSTR4, and this action appears to be mediated by the PI3K pathway., [RefSeq, PubMed]; Sstr4 activation modulates G-protein coupled inward rectifying potassium channels and voltage stimulated calcium signals in dorsal root ganglion neurons, mechanisms thought to contribute to the analgesic propoerties sstr4 agonists, [RefSeq, PubMed]; There is an increase in sst4 and sst2 expression in the habenula, following imipramine administration in a chronic stress model., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004994 somatostatin receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0016477 cell migration;GO:0030900 forebrain development;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0071385 cellular response to glucocorticoid stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P30937-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32244-1", "uniprot_id": [ { "id": "MC3R_RAT", "url": "https://www.uniprot.org/uniprot/P32244", "type": "external" } ], "mass": 35757.0, "length": 323, "protein_name": "Melanocortin receptor 3", "gene_name": "Mc3r", "organism": "Rat", "refseq_name": "melanocortin receptor 3", "refseq_ac": [ { "id": "NP_001020441", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020441", "type": "external" } ], "gene_names_uniprotkb": "Mc3r", "gene_names_refseq": "Mc3r", "protein_names_uniprotkb": "Melanocortin receptor 3; MC3-R", "protein_names_refseq": "MC3-R; melanocortin receptor 3", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29310); (R-RNO-375276)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11963824;12045190;15985309;23571710;26547948;26852738;27713523;31260713;8415620", "class_list": "", "function": "Differential roles for the MC3 and MC4 receptors in TRH release; MC3-R agonism inhibiting and MC4-R agonism stimulating TRH release., [RefSeq, PubMed]; G protein-coupled receptor for melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor. Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway, which contributes to the regulation of energy homeostasis (PubMed:8415620). Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain (By similarity). Binding of the Agouti-related protein/AGPR antagonist precludes alpha-MSH-induced signaling, blocking cAMP production (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Identification of domains directing specificity of coupling to G-proteins, [RefSeq, PubMed]; In rats immunized with M4R and M3R peptides the sensitivity of ACSS thyrocytes to TSH were decreased, whereas in rats iimunized with 5-HT1BR peptide the deficit of thyroid hormones was associated with decreased level of TSH, [RefSeq, PubMed]; MC3R deficiency caused a reduction of food intake and body weight, whereas at the same time exhibited additive effects on top of MC4R deficiency on lipid and glucose metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; Study demonstrates an arcuate nucleus of the hypothalamus pro-opiomelanocortinergic projection onto ventral tegmental area dopaminergic neurons that modulates motivation for palatable food via activation of melanocortin 3 receptor signaling., [RefSeq, PubMed]; The increase in hypothalamic nesfatin-1 participates in regulating feeding behavior through the MC3/4R-ERK signaling especially after SG and RYGB., [RefSeq, PubMed]; We showed that the melanocortin-3/4 receptor antagonist SHU 9119 attenuates the food intake-suppressive effect of aminoprocalcitonin., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q4KXA4", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0017046 peptide hormone binding;GO:0004977 melanocortin receptor activity;GO:0004978 corticotropin receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008217 regulation of blood pressure;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0060259 regulation of feeding behavior;GO:0045475 locomotor rhythm", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P32244-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32821-1", "uniprot_id": [ { "id": "TRYA_RAT", "url": "https://www.uniprot.org/uniprot/P32821", "type": "external" } ], "mass": 26901.0, "length": 246, "protein_name": "Trypsin V-A", "gene_name": "", "organism": "Rat", "refseq_name": "trypsin V-A precursor", "refseq_ac": [ { "id": "NP_001101326", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101326", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "Prss3bl1; Tryx4", "protein_names_uniprotkb": "Trypsin V-A; 3.4.21.4", "protein_names_refseq": "Trypsin V-A; Trypsin V-B; trypsin V a-form; trypsin V b-form; trypsin V-A precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:312273)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1537555", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P32821-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32822-1", "uniprot_id": [ { "id": "TRYB_RAT", "url": "https://www.uniprot.org/uniprot/P32822", "type": "external" } ], "mass": 26820.0, "length": 246, "protein_name": "Trypsin V-B", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Trypsin V-B; 3.4.21.4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1537555", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P32822-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35000-1", "uniprot_id": [ { "id": "VIPR2_RAT", "url": "https://www.uniprot.org/uniprot/P35000", "type": "external" } ], "mass": 49553.0, "length": 437, "protein_name": "Vasoactive intestinal polypeptide receptor 2", "gene_name": "Vipr2", "organism": "Rat", "refseq_name": "vasoactive intestinal polypeptide receptor 2 precursor", "refseq_ac": [ { "id": "NP_058934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058934", "type": "external" } ], "gene_names_uniprotkb": "Vipr2", "gene_names_refseq": "Vipr2", "protein_names_uniprotkb": "Vasoactive intestinal polypeptide receptor 2; PACAP type III receptor; PACAP-R-3; PACAP-R3; Pituitary adenylate cyclase-activating polypeptide type III receptor; VIP-R-2", "protein_names_refseq": "PACAP type III receptor; PACAP-R-3; PACAP-R3; VIP-R-2; pituitary adenylate cyclase-activating polypeptide type III receptor; vasoactive intestinal polypeptide receptor 2 precursor; vasoactive intestinal polypeptide receptor 2; vasopressive intestinal peptide receptor 2", "tax_id": 10116, "disease": "", "pathway": " (rno:29555); (R-RNO-420092)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "15176082;15344914;15514088;23099490;23518767;28776455;36430275;36642263;7988457;8224221", "class_list": "", "function": "Aging reduces vasoactive intestinal peptide (VIP) receptor mRNA within the suprachiasmatic nucleus of aged male rats. A diurnal rhythm of VPAC2 receptor mRNA was present but reduced in the aged rats., [RefSeq, PubMed]; All three PACAP/VIP receptor subtypes are expressed in primary rat adipocytes, but that the VPAC2-R subtype is responsible for mediating the lipolytic effects induced by PACAP38 and VIP., [RefSeq, PubMed]; Both VPAC1 and VPAC2 could have roles at all stages of retinal development, that PACAP acts through a specific set of PAC1 isoforms, and that Hip and Hop1 are predominantly involved in the postnatal development of rat retina. Publication Status: Online-Only, [RefSeq, PubMed]; G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:7988457, PubMed:8224221). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the order of ligand affinity of VIP = PACAP38 > PACAP27 (PubMed:8224221). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:8224221). May be coupled to phospholipase C., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; In cultured rat conjunctival goblet cells, VPAC1 and 2 receptors are functional; VIP stimulates a cAMP-dependent increase in [Ca(2+)]i and glycoconjugate secretion, but not ERK1/2 activation. Publication Status: Online-Only, [RefSeq, PubMed]; PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies. Publication Status: Online-Only, [RefSeq, PubMed]; Presence of vasoactive intestinal peptide (VIP) receptor 2 mRNA is demonstrated at sites putatively innervated by VIP-containing projections from the suprachiasmatic nucleus., [RefSeq, PubMed]; The protein and mRNA expression of pituitary adenylate cyclase-activating polypeptide-related receptors (PAC1, VPAC1, and VPAC2) in the trigeminal ganglia and trigeminal nucleus caudalis to identify changes associated with repetitive applications of chemical dural stimulations., [RefSeq, PubMed]; VPAC2 receptor mediates VIP-potentiated insulin secretion via ion channels in rat pancreatic beta cells., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001634 pituitary adenylate cyclase-activating polypeptide receptor activity;GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0004999 vasoactive intestinal polypeptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190 activation of adenylate cyclase activity;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0048662 negative regulation of smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P35000-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35429-1", "uniprot_id": [ { "id": "HES2_RAT", "url": "https://www.uniprot.org/uniprot/P35429", "type": "external" } ], "mass": 17028.0, "length": 157, "protein_name": "Transcription factor HES-2", "gene_name": "Hes2", "organism": "Rat", "refseq_name": "transcription factor HES-2", "refseq_ac": [ { "id": "NP_062109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062109", "type": "external" } ], "gene_names_uniprotkb": "Hes2; Hes-2", "gene_names_refseq": "Hes2", "protein_names_uniprotkb": "Transcription factor HES-2; Hairy and enhancer of split 2", "protein_names_refseq": "hairy and enhancer of split 2; transcription factor HES-2", "tax_id": 10116, "disease": "central nervous system cancer (Disease Ontology:DOID:3620)", "pathway": " (rno:29567)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18418349;8354270", "class_list": "", "function": "Delta-1/Notch-2/Hes-1 signaling pathway may regulate the regeneration and proliferation of renal tubules during acute kidney injury., [RefSeq, PubMed]; Transcriptional repressor of genes that require a bHLH protein for their transcription., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0003690 double-stranded DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P35429-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36370-1", "uniprot_id": [ { "id": "TAP1_RAT", "url": "https://www.uniprot.org/uniprot/P36370", "type": "external" } ], "mass": 79150.0, "length": 725, "protein_name": "Antigen peptide transporter 1", "gene_name": "Tap1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tap1; Abcb2; Mtp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Antigen peptide transporter 1; 7.4.2.14; APT1; ATP-binding cassette sub-family B member 2; Peptide transporter TAP1", "protein_names_refseq": "", "tax_id": 10116, "disease": "otosclerosis 11 (Disease Ontology:DOID:0060928); open-angle glaucoma (Disease Ontology:DOID:1067); osteoporosis (Disease Ontology:DOID:11476); allergic disease (Disease Ontology:DOID:1205); otosclerosis (Disease Ontology:DOID:12185); diffuse scleroderma (Disease Ontology:DOID:1580); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); cervical cancer (Disease Ontology:DOID:4362); rhinitis (Disease Ontology:DOID:4483); schizophrenia (Disease Ontology:DOID:5419); reactive arthritis (Disease Ontology:DOID:6196); ankylosing spondylitis (Disease Ontology:DOID:7147); extrinsic allergic alveolitis (Disease Ontology:DOID:841); psoriasis (Disease Ontology:DOID:8893); bronchiectasis (Disease Ontology:DOID:9563); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24811); (R-RNO-983170)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17018292;1979660;25377891", "class_list": "", "function": "ABC transporter associated with antigen processing (PubMed:17018292). In complex with TAP2 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules (By similarity). Uses the chemical energy of ATP to export peptides against the concentration gradient (By similarity). During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle (By similarity). As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation (By similarity)., [UniProtKB, UniProtKB, PubMed]; ABC transporter associated with antigen processing. In complex with TAP2 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules. Uses the chemical energy of ATP to export peptides against the concentration gradient. During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle. As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "7.4.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:7.4.2.14", "type": "external" } ], "go_molecular_function": "GO:0046978 TAP1 binding;GO:0046979 TAP2 binding;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0042824 MHC class I peptide loading complex;GO:0042825 TAP complex", "go_biological_process": "GO:0006952 defense response;GO:0015031 protein transport;GO:0055085 transmembrane transport;GO:0042270 protection from natural killer cell mediated cytotoxicity;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P36370-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36372-1", "uniprot_id": [ { "id": "TAP2_RAT", "url": "https://www.uniprot.org/uniprot/P36372", "type": "external" } ], "mass": 77713.0, "length": 703, "protein_name": "Antigen peptide transporter 2", "gene_name": "Tap2", "organism": "Rat", "refseq_name": "antigen peptide transporter 2", "refseq_ac": [ { "id": "NP_114445", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114445", "type": "external" } ], "gene_names_uniprotkb": "Tap2; Abcb3; Mtp2", "gene_names_refseq": "Abcb3; Cim; Tap2", "protein_names_uniprotkb": "Antigen peptide transporter 2; 7.4.2.14; APT2; ATP-binding cassette sub-family B member 3", "protein_names_refseq": "APT2; ATP-binding cassette sub-family B member 3; Transporter 2 ABC (ATP binding cassette); antigen peptide transporter 2; transporter 2 ATP-binding cassette sub-family B; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)", "tax_id": 10116, "disease": "lymphoproliferative syndrome (Disease Ontology:DOID:0060704); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); tuberculoid leprosy (Disease Ontology:DOID:1025); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); dengue hemorrhagic fever (Disease Ontology:DOID:12206); lung cancer (Disease Ontology:DOID:1324); limited scleroderma (Disease Ontology:DOID:1577); diffuse scleroderma (Disease Ontology:DOID:1580); multiple sclerosis (Disease Ontology:DOID:2377); cervix carcinoma (Disease Ontology:DOID:2893); pulmonary tuberculosis (Disease Ontology:DOID:2957); allergic contact dermatitis (Disease Ontology:DOID:3042); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); cervical cancer (Disease Ontology:DOID:4362); reactive arthritis (Disease Ontology:DOID:6196); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24812); (R-RNO-983170)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1350326;17018292;1758495;24586191;29393594;8206525", "class_list": "", "function": "ABC transporter associated with antigen processing (PubMed:17018292). In complex with TAP1 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules (By similarity). Uses the chemical energy of ATP to export peptides against the concentration gradient (By similarity). During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle (By similarity). As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation (By similarity)., [UniProtKB, PubMed, UniProtKB]; Variants of Tap2 have previously been shown to influence the antigenicity of MHC class I molecules . Our results show that a restricted peptide repertoire on MHC class I molecules leads to reduced negative selection of CD8SP cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "7.4.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:7.4.2.14", "type": "external" } ], "go_molecular_function": "GO:0046978 TAP1 binding;GO:0046979 TAP2 binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0042824 MHC class I peptide loading complex;GO:0042825 TAP complex", "go_biological_process": "GO:0015031 protein transport;GO:0055085 transmembrane transport;GO:0042270 protection from natural killer cell mediated cytotoxicity;GO:0002250 adaptive immune response;GO:0001916 positive regulation of T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P36372-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36394-1", "uniprot_id": [ { "id": "SRY_RAT", "url": "https://www.uniprot.org/uniprot/P36394", "type": "external" } ], "mass": 20465.0, "length": 169, "protein_name": "Sex-determining region Y protein", "gene_name": "Sry", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sry; Sry3b2; Tdf", "gene_names_refseq": "", "protein_names_uniprotkb": "Sex-determining region Y protein; Testis-determining factor", "protein_names_refseq": "", "tax_id": 10116, "disease": "46,XX sex reversal 1 (Disease Ontology:DOID:0111761); 46,XY sex reversal 1 (Disease Ontology:DOID:0111778); 46,XY complete gonadal dysgenesis (Disease Ontology:DOID:14448)", "pathway": " (rno:25221); (R-RNO-3769402)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "16414182;16488877;16904257;16996051;8162230;9203057;9571157", "class_list": "", "function": "Transcriptional regulator that controls a genetic switch in male development (PubMed:16414182, PubMed:16996051). It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (PubMed:16414182, PubMed:16996051). Involved in different aspects of gene regulation including promoter activation or repression (PubMed:16488877). Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity). SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending (By similarity). Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (PubMed:16488877)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88776;Q63558", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0008301 DNA binding, bending;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007548 sex differentiation;GO:0030238 male sex determination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P36394-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36510-1", "uniprot_id": [ { "id": "UD2A1_RAT", "url": "https://www.uniprot.org/uniprot/P36510", "type": "external" } ], "mass": 59916.0, "length": 527, "protein_name": "UDP-glucuronosyltransferase 2A1", "gene_name": "Ugt2a1", "organism": "Rat", "refseq_name": "UDP-glucuronosyltransferase 2A1 precursor", "refseq_ac": [ { "id": "NP_071564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071564", "type": "external" } ], "gene_names_uniprotkb": "Ugt2a1; Ugt2a-1", "gene_names_refseq": "Ugt2a1p; Ugt2a1", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 2A1; 2.4.1.17; UDPGT 2A1; UGT-OLF; UGT2A1", "protein_names_refseq": "UDP glucuronosyltransferase 2 family, polypeptide A1; UDP glycosyltransferase 2 family, polypeptide A1; UDP-glucuronosyltransferase 2A1 precursor; UDP-glucuronosyltransferase 2A1; UDPGT 2A1; UGT-OLF", "tax_id": 10116, "disease": "", "pathway": " (rno:63867); (R-RNO-156588); (R-RNO-9749641)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11376859;15240697;1900353;33765098", "class_list": "glycogene;glycosyltransferase", "function": "The odorant metabolizing enzyme UGT2A1: Immunolocalization and impact of the modulation of its activity on the olfactory response. Erratum:[PLoS One. 2024 Feb 23;19(2):e0299662. doi: 10.1371/journal.pone.0299662. PMID: 38394150] Publication Status: Online-Only, [RefSeq, PubMed]; UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterones) and estrogens (estradiol and estriol). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Shows a high affinity to aliphatic odorants such as citronellol as well as olfactory tissue specificity, and therefore may be involved in olfaction., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" } ], "go_molecular_function": "GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0009636 response to toxic substance;GO:0008206 bile acid metabolic process;GO:0007608 sensory perception of smell;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P36510-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36511-1", "uniprot_id": [ { "id": "UDB15_RAT", "url": "https://www.uniprot.org/uniprot/P36511", "type": "external" } ], "mass": 61060.0, "length": 530, "protein_name": "UDP-glucuronosyltransferase 2B15", "gene_name": "Ugt2b15; Ugt2b35", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ugt2b15; Ugt2b35; Ugt2b12; Ugt2b15; Ugt2b36; Ugt2b4", "gene_names_refseq": "", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 2B15; 2.4.1.17; UDP-glucuronosyltransferase 2B36; UDPGT 2B15; UDPGT 2B36; UGT2B15", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:83808); (R-RNO-156588); (R-RNO-9749641); (R-RNO-9753281); (R-RNO-9757110)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "1906977;7574722", "class_list": "glycogene;glycosyltransferase", "function": "UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:7574722). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:7574722). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens) (PubMed:7574722). Displays glucuronidation activity toward several classes of xenoblotic substrates, including phenolic compounds (eugenol, 4-nitrophenol, 4-hydroxybiphenyl) and phenylpropanoids (naringenin, coumarins) (PubMed:7574722). Catalyzes the glucuronidation of monoterpenoid alcohols such as borneol, menthol and isomenthol, a class of natural compounds used in essential oils (PubMed:7574722)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" } ], "go_molecular_function": "GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P36511-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38438-1", "uniprot_id": [ { "id": "TGFR2_RAT", "url": "https://www.uniprot.org/uniprot/P38438", "type": "external" } ], "mass": 64241.0, "length": 567, "protein_name": "TGF-beta receptor type-2", "gene_name": "Tgfbr2", "organism": "Rat", "refseq_name": "TGF-beta receptor type-2 precursor", "refseq_ac": [ { "id": "NP_112394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112394", "type": "external" } ], "gene_names_uniprotkb": "Tgfbr2", "gene_names_refseq": "TGF-beta 2; Tgfbr2T; Tgfbr2", "protein_names_uniprotkb": "TGF-beta receptor type-2; 2.7.11.30; TGF-beta receptor type II; TGF-beta type II receptor; TGFR-2; TbetaR-II; Transforming growth factor-beta receptor type II", "protein_names_refseq": "TGF-beta receptor type II; TGF-beta receptor type-2 precursor; TGF-beta receptor type-2; TGF-beta type II receptor; TGFR-2; tbetaR-II; transforming growth factor beta receptor type II; transforming growth factor, beta receptor IIT; transforming growth factor, beta receptor II; transforming growth factor-b type II receptor; transforming growth factor-beta type II receptor", "tax_id": 10116, "disease": "Loeys-Dietz syndrome (Disease Ontology:DOID:0050466); small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); Loeys-Dietz syndrome 2 (Disease Ontology:DOID:0070234); hereditary nonpolyposis colorectal cancer type 6 (Disease Ontology:DOID:0070273); cleft soft palate (Disease Ontology:DOID:0110214); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); prostate cancer (Disease Ontology:DOID:10283); DiGeorge syndrome (Disease Ontology:DOID:11198); Marfan syndrome (Disease Ontology:DOID:14323); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); arteriosclerosis (Disease Ontology:DOID:2349); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); pulmonary fibrosis (Disease Ontology:DOID:3770); Lynch syndrome (Disease Ontology:DOID:3883); vasculogenic impotence (Disease Ontology:DOID:4762); cholangiocarcinoma (Disease Ontology:DOID:4947); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:81810); (R-RNO-2173788); (R-RNO-2173789); (R-RNO-2173791); (R-RNO-9839389)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "22673903;29196166;29393594;30468668;31147562;8264154;8385453", "class_list": "", "function": "Data suggest that the chloride channel-3 (CLC-3) might be modulated by transforming growth factor beta (TGF-beta) / TGF-beta Receptor II (TGF- beta RII) signaling pathway during the development of diabetic encephalopathy (DE). Publication Status: Online-Only, [RefSeq, PubMed]; Epidermal Growth Factor Stimulates Transforming Growth Factor-Beta Receptor Type II Expression In Corneal Epithelial Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Findings outlined in the current study demonstrated that 1,25(OH)2D3 was a promising therapeutic modality for treatment of Pulmonary arterial hypertension, function of which was exerted through miR-204 mediated Tgfbr2 signaling., [RefSeq, PubMed]; Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0034714 type III transforming growth factor beta receptor binding;GO:0060090 molecular adaptor activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0002666 positive regulation of T cell tolerance induction;GO:1990086 lens fiber cell apoptotic process;GO:0060439 trachea morphogenesis;GO:0035162 embryonic hemopoiesis;GO:0060443 mammary gland morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38438-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41224-1", "uniprot_id": [ { "id": "TEF_RAT", "url": "https://www.uniprot.org/uniprot/P41224", "type": "external" } ], "mass": 33159.0, "length": 301, "protein_name": "Thyrotroph embryonic factor", "gene_name": "Tef", "organism": "Rat", "refseq_name": "thyrotroph embryonic factor", "refseq_ac": [ { "id": "NP_062067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062067", "type": "external" } ], "gene_names_uniprotkb": "Tef", "gene_names_refseq": "Tef", "protein_names_uniprotkb": "Thyrotroph embryonic factor", "protein_names_refseq": "TEF, PAR bZIP transcription factor; thyrotroph embryonic factor; thyrotrophic embryonic factor", "tax_id": 10116, "disease": "acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:29362)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1916262;24147051", "class_list": "", "function": "Findings suggest that prenatal HFD exposure inactivates both hypothalamic TEF and YAP, by either decreasing their levels or increasing their inactive form, and that this contributes to the stimulatory effect of HFD on ENK expression. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T1I8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0003690 double-stranded DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048511 rhythmic process;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P41224-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41244-1", "uniprot_id": [ { "id": "VEGP2_RAT", "url": "https://www.uniprot.org/uniprot/P41244", "type": "external" } ], "mass": 19699.0, "length": 177, "protein_name": "von Ebner gland protein 2", "gene_name": "Vegp2", "organism": "Rat", "refseq_name": "von Ebner gland protein 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_446026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446026", "type": "external" } ], "gene_names_uniprotkb": "Vegp2", "gene_names_refseq": "Vegp2", "protein_names_uniprotkb": "von Ebner gland protein 2; VEG protein 2", "protein_names_refseq": "VEG protein 2; von Ebner gland protein 2 isoform 1 precursor; von Ebner gland protein 2-like; von Ebner gland protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:94106); (R-RNO-804914)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "7514123", "class_list": "", "function": "Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036094 small molecule binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050909 sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P41244-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42123-1", "uniprot_id": [ { "id": "LDHB_RAT", "url": "https://www.uniprot.org/uniprot/P42123", "type": "external" } ], "mass": 36612.0, "length": 334, "protein_name": "L-lactate dehydrogenase B chain", "gene_name": "Ldhb", "organism": "Rat", "refseq_name": "L-lactate dehydrogenase B chain isoform Ldhbx", "refseq_ac": [ { "id": "NP_001303262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303262", "type": "external" } ], "gene_names_uniprotkb": "Ldhb; Ldh-2; Ldh2", "gene_names_refseq": "Ldh2; Ldhb", "protein_names_uniprotkb": "L-lactate dehydrogenase B chain; 1.1.1.27; LDH heart subunit; LDH-B; LDH-H", "protein_names_refseq": "L-lactate dehydrogenase B chain isoform Ldhbx; L-lactate dehydrogenase B chain; LDH heart subunit; LDH-B; LDH-H; Lactate dehydrogenease B", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667)", "pathway": " (rno:24534); (R-RNO-70268)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "22673903;25247702;30618075;34502162;7937776", "class_list": "", "function": "Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+)., [UniProtKB, UniProtKB]; MiR-375-3p inhibitor suppresses Ang II-induced cardiomyocyte hypertrophy by promoting LDHB expression., [RefSeq, PubMed]; The readthrough-extended lactate dehydrogenase subunit LDHBx can also co-import LDHA, the other LDH subunit, into peroxisomes. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have also been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 9. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.27", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0019900 kinase binding;GO:0004459 L-lactate dehydrogenase (NAD+) activity;GO:0004457 lactate dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0045121 membrane raft;GO:1990204 oxidoreductase complex", "go_biological_process": "GO:0019674 NAD+ metabolic process;GO:0006089 lactate metabolic process;GO:0042867 pyruvate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P42123-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48763-1", "uniprot_id": [ { "id": "SL9A2_RAT", "url": "https://www.uniprot.org/uniprot/P48763", "type": "external" } ], "mass": 91403.0, "length": 813, "protein_name": "Sodium/hydrogen exchanger 2", "gene_name": "Slc9a2", "organism": "Rat", "refseq_name": "sodium/hydrogen exchanger 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001106806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106806", "type": "external" } ], "gene_names_uniprotkb": "Slc9a2; Nhe2", "gene_names_refseq": "Nhe2; Slc9a2", "protein_names_uniprotkb": "Sodium/hydrogen exchanger 2; H7; NHE-2; Na(+)/H(+) exchanger 2; Solute carrier family 9 member 2", "protein_names_refseq": "H7; NHE-2; Na(+)/H(+) exchanger 2; Na/H ion exchanger; Solute carrier family 9 (sodium/hydrogen exchanger 2), antiporter 2, Na+/H+ (Na+/H+ exchanger 2); sodium/hydrogen exchanger 2 isoform 1 precursor; sodium/hydrogen exchanger 2; solute carrier family 9 (sodium/hydrogen exchanger), member 2; solute carrier family 9 member 2; solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2", "tax_id": 10116, "disease": "", "pathway": " (rno:24783); (R-RNO-425986)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10678742;12576672;22673903;26078707;26350456;27191152;28019659;28493993;7683411;7685026;8244988;8244989;8595899", "class_list": "", "function": "Enhanced expression of NHE-1, 2 and 4 proteins and mRNAs expression in cervix under genistein influence could help to restore the cervicovaginal fluid pH that might help to prevent cervicovaginal complications related to menopause Publication Status: Online-Only, [RefSeq, PubMed]; Observations suggest that the butyrate activation of NHE2 would be a potential target to control UC-associated diarrhea, [RefSeq, PubMed]; Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:10678742, PubMed:8244988, PubMed:8244989). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt. Controls in the colonic crypt intracellular pH (pHi) to direct colonic epithelial cell differentiation into the absorptive enterocyte lineage at the expense of the secretory lineage (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Results provide evidence that NHE2 and AQP2 work in coordination as part of the cellular device that regulates collecting duct cell cycle progression., [RefSeq, PubMed]; The results demonstrate that in RGM1 cells, migratory velocity is increased by NHE1 activation, while NHE2 activity inhibit this process., [RefSeq, PubMed]; These findings demonstrate suppression of NHE-2 expression on the brush borders in the colonic epithelial cells which is regulated transcriptionally. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q16434", "ec_number_list": [], "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015386 potassium:proton antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0008104 intracellular protein localization;GO:0035725 sodium ion transmembrane transport;GO:0006814 sodium ion transport;GO:0051453 regulation of intracellular pH", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P48763-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50408-1", "uniprot_id": [ { "id": "VATF_RAT", "url": "https://www.uniprot.org/uniprot/P50408", "type": "external" } ], "mass": 13370.0, "length": 119, "protein_name": "V-type proton ATPase subunit F", "gene_name": "Atp6v1f", "organism": "Rat", "refseq_name": "V-type proton ATPase subunit F", "refseq_ac": [ { "id": "NP_446336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446336", "type": "external" } ], "gene_names_uniprotkb": "Atp6v1f; Atp6s14; Vatf", "gene_names_refseq": "Atp6s14; Atp6v1f", "protein_names_uniprotkb": "V-type proton ATPase subunit F; V-ATPase 14 kDa subunit; V-ATPase subunit F; Vacuolar proton pump subunit F", "protein_names_refseq": "ATPase, H transporting, lysosomal V1 subunit F; ATPase, H+ transporting, lysosomal V1, subunit F; ATPase, vacuolar, 14 kD; V-ATPase 14 kDa subunit; V-ATPase subunit F; V-type proton ATPase subunit F; vacuolar proton pump subunit F", "tax_id": 10116, "disease": "", "pathway": " (rno:116664); (R-RNO-1222556); (R-RNO-77387); (R-RNO-917977); (R-RNO-9639288); (R-RNO-983712)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "32165585;8621738", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32165585). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (PubMed:32165585). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0033176 proton-transporting V-type ATPase complex;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0016020 membrane;GO:0030665 clathrin-coated vesicle membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex", "go_biological_process": "GO:0097401 synaptic vesicle lumen acidification", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P50408-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50475-1", "uniprot_id": [ { "id": "SYAC_RAT", "url": "https://www.uniprot.org/uniprot/P50475", "type": "external" } ], "mass": 106790.0, "length": 968, "protein_name": "Alanine--tRNA ligase, cytoplasmic", "gene_name": "Aars1", "organism": "Rat", "refseq_name": "alanine--tRNA ligase, cytoplasmic", "refseq_ac": [ { "id": "NP_001093987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093987", "type": "external" } ], "gene_names_uniprotkb": "Aars1; Aars", "gene_names_refseq": "Aars1; Aars", "protein_names_uniprotkb": "Alanine--tRNA ligase, cytoplasmic; 6.-.-.-; 6.1.1.7; AlaRS; Alanyl-tRNA synthetase; Protein lactyltransferase AARS1", "protein_names_refseq": "alaRS; alanine--tRNA ligase, cytoplasmic; alanyl-tRNA synthetase, cytoplasmic; protein lactyltransferase AARS1", "tax_id": 10116, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); nonphotosensitive trichothiodystrophy 8 (Disease Ontology:DOID:0061023); developmental and epileptic encephalopathy 29 (Disease Ontology:DOID:0080451); Charcot-Marie-Tooth disease axonal type 2N (Disease Ontology:DOID:0110177); dermatomyositis (Disease Ontology:DOID:10223); leukodystrophy (Disease Ontology:DOID:10579); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); microcephaly (Disease Ontology:DOID:10907); axonal neuropathy (Disease Ontology:DOID:7319)", "pathway": " (rno:292023)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2040280;29393594", "class_list": "", "function": "Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1. Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins. Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53. Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6IZ80;Q4G057", "ec_number_list": [ { "id": "6.1.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.7", "type": "external" }, { "id": "6.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016597 amino acid binding;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0050885 neuromuscular process controlling balance;GO:0050905 neuromuscular process;GO:0006400 tRNA modification;GO:0043524 negative regulation of neuron apoptotic process;GO:0006419 alanyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P50475-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50569-1", "uniprot_id": [ { "id": "STF1_RAT", "url": "https://www.uniprot.org/uniprot/P50569", "type": "external" } ], "mass": 52087.0, "length": 462, "protein_name": "Steroidogenic factor 1", "gene_name": "Nr5a1", "organism": "Rat", "refseq_name": "steroidogenic factor 1 isoform 1", "refseq_ac": [ { "id": "NP_001178028", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178028", "type": "external" } ], "gene_names_uniprotkb": "Nr5a1; Ftzf1", "gene_names_refseq": "Ad4BP/SF-1; Ad4bp; Ftzf1; Nr5a1; Sf-1", "protein_names_uniprotkb": "Steroidogenic factor 1; Adrenal 4-binding protein; Fushi tarazu factor homolog 1; Nuclear receptor subfamily 5 group A member 1; SF-1; STF-1; Steroid hormone receptor Ad4BP", "protein_names_refseq": "STF-1; adrenal 4-binding protein; fushi tarazu factor homolog 1; steroid hormone receptor Ad4BP; steroidogenic factor 1 isoform 1; steroidogenic factor 1", "tax_id": 10116, "disease": "spermatogenic failure 8 (Disease Ontology:DOID:0070169); primary ovarian insufficiency 7 (Disease Ontology:DOID:0080864); hypogonadotropic hypogonadism (Disease Ontology:DOID:0090070); 46,XX sex reversal 4 (Disease Ontology:DOID:0111764); 46,XY sex reversal 3 (Disease Ontology:DOID:0111772); gonadal dysgenesis (Disease Ontology:DOID:14447); Zellweger syndrome (Disease Ontology:DOID:905)", "pathway": " (rno:83826); (R-RNO-383280); (R-RNO-4090294)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "31041823;36857632;39024550;39094930;7706291;8395654", "class_list": "", "function": "DNA methylation of Ad4BP/SF-1 suppresses Cyp11a1 and StAR transcripts in C2C12 myoblasts., [RefSeq, PubMed]; Steroidogenic Factor-1 Regulation of Dorsomedial Ventromedial Hypothalamic Nucleus Ghrh Neuron Transmitter Marker and Estrogen Receptor Gene Expression in Male Rat., [RefSeq, PubMed]; TGF-beta1 induced activations of Smad2 and miRNAs inhibit SF-1- and LRH-1-dependent CYP19 expression in rat Leydig cellsdagger., [RefSeq, PubMed]; The effect of clomiphene citrate and human chorionic gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as well as the structural changes in testicular tissue of adult rats., [RefSeq, PubMed]; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0007530 sex determination;GO:2000020 positive regulation of male gonad development;GO:0097720 calcineurin-mediated signaling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P50569-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50745-1", "uniprot_id": [ { "id": "SH2B3_RAT", "url": "https://www.uniprot.org/uniprot/P50745", "type": "external" } ], "mass": 40432.0, "length": 368, "protein_name": "SH2B adapter protein 3", "gene_name": "Sh2b3", "organism": "Rat", "refseq_name": "SH2B adapter protein 3 isoform X2", "refseq_ac": [ { "id": "XP_063127675", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063127675", "type": "external" } ], "gene_names_uniprotkb": "Sh2b3; Lnk", "gene_names_refseq": "Lnk; Sh2b3", "protein_names_uniprotkb": "SH2B adapter protein 3; Lymphocyte adapter protein; Lymphocyte-specific adapter protein Lnk; Signal transduction protein Lnk", "protein_names_refseq": "SH2B adapter protein 3 isoform X2", "tax_id": 10116, "disease": "familial erythrocytosis 1 (Disease Ontology:DOID:0060652); colorectal carcinoma (Disease Ontology:DOID:0080199); hypertension (Disease Ontology:DOID:10763); essential thrombocythemia (Disease Ontology:DOID:2224); myelofibrosis (Disease Ontology:DOID:4971); chronic myeloid leukemia (Disease Ontology:DOID:8552); colorectal cancer (Disease Ontology:DOID:9256); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8524815", "class_list": "", "function": "Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0005173 stem cell factor receptor binding;GO:0044877 protein-containing complex binding;GO:0030159 signaling receptor complex adaptor activity;GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "", "go_biological_process": "GO:1990869 cellular response to chemokine;GO:0035162 embryonic hemopoiesis;GO:0070100 negative regulation of chemokine-mediated signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P50745-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60042-1", "uniprot_id": [ { "id": "SMS_RAT", "url": "https://www.uniprot.org/uniprot/P60042", "type": "external" } ], "mass": 12746.0, "length": 116, "protein_name": "Somatostatin", "gene_name": "Sst", "organism": "Rat", "refseq_name": "somatostatin precursor", "refseq_ac": [ { "id": "NP_036791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036791", "type": "external" } ], "gene_names_uniprotkb": "Sst; Smst", "gene_names_refseq": "SRIF; SS-14; SS-28; Smst; Sst", "protein_names_uniprotkb": "Somatostatin; SRIF; somatotropin release-inhibiting factor", "protein_names_refseq": "somatostatin precursor; somatotropin release-inhibiting factor", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (rno:24797); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "18753129;20056135;21325646;21978882;22170057;24308227;24321530;24735892;24846611;26115586;26561648;2863939;2891188;6120163;6133871;6145156;6148343", "class_list": "", "function": "Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin., [UniProtKB, UniProtKB]; May enhance low-glucose-induced glucagon release by pancreatic alpha cells (PubMed:24735892). This effect may be mediated by binding to GPR107 and PKA activation (PubMed:26561648). May regulate cardiac contractile function (PubMed:22170057). May compromise cardiomyocyte viability (PubMed:22170057). In the central nervous system, may impair memory retention and may affect hippocampal excitability (PubMed:21978882). May also have anxiolytic and anorexigenic effects (PubMed:18753129, PubMed:21978882). May play a role in arterial pressure regulation (PubMed:18753129, PubMed:21978882). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH (By similarity). Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic alpha-cells., [RefSeq, PubMed]; Results suggest that somatostatin suppresses GABA release from the amacrine cells by inhibiting presynaptic Ca2+ channels, in part through activating sst5/sst2 receptors, a process that is mediated by the intracellular cAMP-PKA signaling pathway, [RefSeq, PubMed]; Study suggested that somatostatin and nNOS are expressed in most interneurons whereas CB1 receptor is present in both interneurons and projection neurons in hippocampal regions, [RefSeq, PubMed]; The aim of this study was to define all the areas of changes in expression of nuclear c-Fos protein (c-Fos), cytoplasmic somatostatin (SS) and neuropeptide Y (NPY) in rat brain during experimental ischemia., [RefSeq, PubMed]; These results suggest that a local release of somatostatin facilitates the excitability of trigeminal nocicepitve C1 neuronal activity via inhibition of GABAergic neurons, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P01167", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005179 hormone activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0098992 neuronal dense core vesicle;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0043025 neuronal cell body", "go_biological_process": "GO:0048545 response to steroid hormone;GO:0030334 regulation of cell migration;GO:0009410 response to xenobiotic stimulus;GO:0010447 response to acidic pH;GO:0043200 response to amino acid", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P60042-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22071-1", "uniprot_id": [ { "id": "3BHS1_RAT", "url": "https://www.uniprot.org/uniprot/P22071", "type": "external" } ], "mass": 42037.0, "length": 373, "protein_name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1", "gene_name": "Hsd3b1; Hsd3b2; Hsd3b3", "organism": "Rat", "refseq_name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1", "refseq_ac": [ { "id": "NP_001007720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007720", "type": "external" } ], "gene_names_uniprotkb": "Hsd3b1; Hsd3b2; Hsd3b3; Hsd3b1; Hsd3b3", "gene_names_refseq": "Hsd3b1", "protein_names_uniprotkb": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; 1.1.1.145; 1.1.1.210; 1.1.1.270; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase; 5.3.3.1; Delta-5-3-ketosteroid isomerase; Dihydrotestosterone oxidoreductase; Steroid Delta-isomerase", "protein_names_refseq": "3 beta-hydroxysteroid dehydrogenase 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase; 3betaHSD; delta-5-3-ketosteroid isomerase; dihydrotestosterone oxidoreductase; hydroxysteroid dehydrogenase-1, delta<5>-3-beta; steroid Delta-isomerase", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); polycystic ovary syndrome (Disease Ontology:DOID:11612); hyperprolactinemia (Disease Ontology:DOID:12700); hypothyroidism (Disease Ontology:DOID:1459); hypogonadism (Disease Ontology:DOID:1924); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:360348); (R-RNO-193048); (R-RNO-193993); (R-RNO-194002)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "1537836;1955079;1985917;22217836;23332974;34215832", "class_list": "", "function": "A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone (PubMed:1537836, PubMed:1985917). Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone (PubMed:1537836). Expected to use NAD(+) as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity (Probable)., [UniProtKB, PubMed, PubMed]; Data suggest that cAMP mediates transcriptional regulation of Hsd3b1 in Leydig cells (i.e., both normal Leydig cells and Leydig tumor cells); luteinizing hormone may be required to maintain expression of testicular Hsd3b1., [RefSeq, PubMed]; Flutamide treatment reveals a relationship between steroidogenic activity of Leydig cells and ultrastructure of their mitochondria. Publication Status: Online-Only, [RefSeq, PubMed]; Leptin, which inhibits the ovulatory process, caused a significant reduction in the ovarian expression of P450scc without changes in StAR or 3betaHSD., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q19P43", "ec_number_list": [ { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.1.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.145", "type": "external" }, { "id": "5.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.1", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" } ], "go_molecular_function": "GO:0051287 NAD binding;GO:0003854 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity;GO:0004769 steroid Delta-isomerase activity;GO:0005496 steroid binding;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043279 response to alkaloid;GO:0030851 granulocyte differentiation;GO:0046685 response to arsenic-containing substance;GO:0010288 response to lead ion;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P22071-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMR7-1", "uniprot_id": [ { "id": "MOT7_RAT", "url": "https://www.uniprot.org/uniprot/Q7TMR7", "type": "external" } ], "mass": 57261.0, "length": 522, "protein_name": "Monocarboxylate transporter 7", "gene_name": "Slc16a6", "organism": "Rat", "refseq_name": "monocarboxylate transporter 7 isoform 1", "refseq_ac": [ { "id": "NP_942055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942055", "type": "external" } ], "gene_names_uniprotkb": "Slc16a6", "gene_names_refseq": "MCT 6; MCT 7; Mct7B; Slc16a6", "protein_names_uniprotkb": "Monocarboxylate transporter 7; MCT 6; MCT 7; Monocarboxylate transporter 6; Solute carrier family 16 member 6", "protein_names_refseq": "monocarboxylate transporter 6; monocarboxylate transporter 7 isoform 1; monocarboxylate transporter 7B; solute carrier family 16 (monocarboxylic acid transporters), member 6; solute carrier family 16, member 6 (monocarboxylic acid transporter 7)", "tax_id": 10116, "disease": "", "pathway": " (rno:303772)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35257743", "class_list": "", "function": "Monocarboxylate transporter selective for taurine. May associate with BSG/CD147 or EMB/GP70 ancillary proteins to mediate facilitative efflux or influx of taurine across the plasma membrane. The transport is pH- and sodium-independent. Rather low-affinity, is likely effective for taurine transport in tissues where taurine is present at high concentrations., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005368 taurine transmembrane transporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TMR7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20156-1", "uniprot_id": [ { "id": "VGF_RAT", "url": "https://www.uniprot.org/uniprot/P20156", "type": "external" } ], "mass": 68179.0, "length": 617, "protein_name": "Neurosecretory protein VGF", "gene_name": "Vgf", "organism": "Rat", "refseq_name": "neurosecretory protein VGF precursor", "refseq_ac": [ { "id": "NP_112259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112259", "type": "external" } ], "gene_names_uniprotkb": "Vgf", "gene_names_refseq": "Vgf", "protein_names_uniprotkb": "Neurosecretory protein VGF; VGF8a protein", "protein_names_refseq": "VGF8a protein; neurosecretory protein VGF precursor; neurosecretory protein VGF-like; neurosecretory protein VGF", "tax_id": 10116, "disease": "", "pathway": " (rno:29461); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "12065665;1377233;16983076;19164277;19194657;19466987;2017159;20551287;23940034;24106277;24704271;25280008;25569790;25917832;2676516;28123945;28213131;30371765;33245952;35594706;7595538", "class_list": "", "function": "Evaluation of VGF peptides as potential anti-obesity candidates in pre-clinical animal models., [RefSeq, PubMed]; Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons (PubMed:24704271). Also stimulates feeding behavior in an orexin-dependent manner in the hypothalamus (PubMed:20551287). Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying (PubMed:28213131)., [UniProtKB, PubMed, PubMed, PubMed]; Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons., [UniProtKB, PubMed]; Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation (By similarity). Also induces insulin secretion in insulinoma cells by increasing intracellular calcium mobilization (PubMed:25917832)., [UniProtKB, PubMed, UniProtKB]; Results indicate that neuron-restrictive silencer factor plays an important role as a repressor of VGF gene regulation in neuroblastoma cells through a mechanism that is dependent on VGF-neuron-restrictive silencer element, [RefSeq, PubMed]; Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis (PubMed:16983076, PubMed:28123945). Activates the G protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes (PubMed:23940034, PubMed:28123945). Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity (PubMed:19466987, PubMed:24106277)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (PubMed:12065665, PubMed:7595538). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Sexually experienced males. VGF-derived neuropeptides presumably serve as an effector molecule to increase sexual activity following sexual arousal induction., [RefSeq, PubMed]; VGF: A prospective biomarker and therapeutic target for neuroendocrine and nervous system disorders. Review article, [RefSeq, PubMed]; Various VGF peptides may regulate the hypothalamus-pituitary complex via specific neuroendocrine mechanisms while TLQP peptides may act at further, multiple levels via endocrine mechanisms involving the ovary. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:0033500 carbohydrate homeostasis;GO:0006091 generation of precursor metabolites and energy;GO:0009409 response to cold;GO:0048167 regulation of synaptic plasticity;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P20156-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52844-1", "uniprot_id": [ { "id": "ST1E1_RAT", "url": "https://www.uniprot.org/uniprot/P52844", "type": "external" } ], "mass": 35362.0, "length": 295, "protein_name": "Sulfotransferase 1E1", "gene_name": "Sult1e1", "organism": "Rat", "refseq_name": "sulfotransferase 1E1", "refseq_ac": [ { "id": "NP_037015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037015", "type": "external" } ], "gene_names_uniprotkb": "Sult1e1; Ste1; Ste2; Ste", "gene_names_refseq": "EST-1; EST-2; EST-3; EST-6; ESTSUL; ST1E1; Ste1; Ste; Sult1e1; rEST-6; ste2", "protein_names_uniprotkb": "Sulfotransferase 1E1; 2.8.2.4; EST-1; EST-6; Estrogen sulfotransferase, isoform 1; Estrogen sulfotransferase, isoform 6; Estrone sulfotransferase; ST1E1; Sulfotransferase, estrogen-preferring", "protein_names_refseq": "estrogen sulfotransferase; estrone sulfotransferase; sulfotransferase 1E1; sulfotransferase family 1E, estrogen-preferring, member 1; sulfotransferase, estrogen-preferring", "tax_id": 10116, "disease": "X-linked intellectual developmental disorder 109 (Disease Ontology:DOID:0080984); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:360268)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12173467;1374839;22673903;7857871;8688469", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:7857871). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine. May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P49889;P49890;P52845;Q9QWS0", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.14", "type": "external" }, { "id": "2.8.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.2", "type": "external" }, { "id": "2.8.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.1", "type": "external" }, { "id": "2.8.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.4", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0004304 estrone sulfotransferase activity;GO:0047894 flavonol 3-sulfotransferase activity;GO:0050294 steroid sulfotransferase activity;GO:0005496 steroid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0051923 sulfation;GO:0006711 estrogen catabolic process;GO:0045600 positive regulation of fat cell differentiation;GO:0006068 ethanol catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P52844-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ABY1-1", "uniprot_id": [ { "id": "D4ABY1_RAT", "url": "https://www.uniprot.org/uniprot/D4ABY1", "type": "external" } ], "mass": 48126.0, "length": 424, "protein_name": "Serine/threonine-protein kinase H1", "gene_name": "Pskh1", "organism": "Rat", "refseq_name": "protein serine kinase H1", "refseq_ac": [ { "id": "NP_001420353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001420353", "type": "external" } ], "gene_names_uniprotkb": "Pskh1", "gene_names_refseq": "Pskh1", "protein_names_uniprotkb": "Serine/threonine-protein kinase H1; 2.7.11.1; Protein serine kinase H1", "protein_names_refseq": "protein serine kinase H1; serine/threonine-protein kinase H1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine protein kinase that may be involved in the regulation of pre-mRNA processing. It may phosphorylate components of nuclear splice factor compartments (SFC), such as non-snRNP splicing factors containing a serine/arginine-rich domain (SR proteins). Reversible phosphorylation of SR proteins may cause their release into the nucleoplasm and change their local concentration, thereby influencing alternative splicing., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2K3Z0", "ec_number_list": [], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007507 heart development;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ABY1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V924-1", "uniprot_id": [ { "id": "G3V924_RAT", "url": "https://www.uniprot.org/uniprot/G3V924", "type": "external" } ], "mass": 45561.0, "length": 407, "protein_name": "Transmembrane protein 184B", "gene_name": "Tmem184b", "organism": "Rat", "refseq_name": "transmembrane protein 184B", "refseq_ac": [ { "id": "NP_001166841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166841", "type": "external" } ], "gene_names_uniprotkb": "Tmem184b", "gene_names_refseq": "RGD1306591; Tmem184b", "protein_names_uniprotkb": "Transmembrane protein 184B", "protein_names_refseq": "transmembrane protein 184B", "tax_id": 10116, "disease": "", "pathway": " (rno:362959)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V924-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G4XVC3-1", "uniprot_id": [ { "id": "G4XVC3_RAT", "url": "https://www.uniprot.org/uniprot/G4XVC3", "type": "external" } ], "mass": 31569.0, "length": 296, "protein_name": "Family with sequence similarity 110, member A", "gene_name": "Fam110a", "organism": "Rat", "refseq_name": "protein FAM110A isoform 1", "refseq_ac": [ { "id": "NP_001231698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231698", "type": "external" } ], "gene_names_uniprotkb": "Fam110a", "gene_names_refseq": "Fam110a; RGD1308904", "protein_names_uniprotkb": "Family with sequence similarity 110, member A", "protein_names_refseq": "protein FAM110A isoform 1; serine threonine rich protein", "tax_id": 10116, "disease": "", "pathway": " (rno:311535)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005938 cell cortex", "go_biological_process": "GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G4XVC3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6HD62-1", "uniprot_id": [ { "id": "CHIP_RAT", "url": "https://www.uniprot.org/uniprot/A6HD62", "type": "external" } ], "mass": 34886.0, "length": 304, "protein_name": "E3 ubiquitin-protein ligase CHIP", "gene_name": "Stub1", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase CHIP", "refseq_ac": [ { "id": "NP_001020796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020796", "type": "external" } ], "gene_names_uniprotkb": "Stub1; Chip", "gene_names_refseq": "Chip; Stub1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase CHIP; 2.3.2.27; Carboxy terminus of Hsp70-interacting protein; RING-type E3 ubiquitin transferase CHIP; STIP1 homology and U box-containing protein 1", "protein_names_refseq": "E3 ubiquitin-protein ligase CHIP; RING-type E3 ubiquitin transferase CHIP; STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; carboxy terminus of Hsp70-interacting protein", "tax_id": 10116, "disease": "autosomal recessive spinocerebellar ataxia 16 (Disease Ontology:DOID:0080029); cerebellar ataxia type 48 (Disease Ontology:DOID:0111746); Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (rno:287155)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19237536;19483080;20724525;21808025;26265139;29934347;30222779;30980393;37992540;38085649", "class_list": "", "function": "CHIP attenuates LPS-induced cardiac hypertrophy., [RefSeq, PubMed]; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation (PubMed:26265139). Plays a role in the maintenance of mitochondrial morphology and promotes mitophagic removal of dysfunctional mitochondria; thereby acts as a protector against apoptosis in response to cellular stress (PubMed:29934347). Negatively regulates vascular smooth muscle contraction, via degradation of the transcriptional activator MYOCD and subsequent loss of transcription of genes involved in vascular smooth muscle contraction (PubMed:19237536). Promotes survival and proliferation of cardiac smooth muscle cells via ubiquitination and degradation of FOXO1, resulting in subsequent repression of FOXO1-mediated transcription of pro-apoptotic genes (PubMed:19483080). Ubiquitinates ICER-type isoforms of CREM and targets them for proteasomal degradation, thereby acts as a positive effector of MAPK/ERK-mediated inhibition of apoptosis in cardiomyocytes (PubMed:20724525). Inhibits lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes, via ubiquitination and subsequent proteasomal degradation of NFATC3 (PubMed:30980393). Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Ubiquitinates NOS1 in concert with Hsp70 and Hsp40 (By similarity). Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90 (By similarity). Ubiquitinates CHRNA3 targeting it for endoplasmic reticulum-associated degradation in cortical neurons, as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Ubiquitinates and promotes ESR1 proteasomal degradation in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (PubMed:21808025). Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation (By similarity). Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome (By similarity). Mediates polyubiquitination of CYP3A4 (By similarity). Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation (By similarity). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (By similarity). Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (By similarity). Catalyzes monoubiquitination of SIRT6, preventing its degradation by the proteasome (By similarity). Likely mediates polyubiquitination and down-regulates plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity (By similarity). Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (By similarity). Plays a role in the degradation of TP53 (By similarity). Mediates ubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation (By similarity). May regulate myosin assembly in striated muscles together with UBE4B and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (By similarity). Ubiquitinates PPARG in macrophages playing a role in M2 macrophages polarization and angiogenesis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; In forebrain neuron cultures, C terminus of HSC70-Interacting Protein (CHIP) is critical for neuronal responses to stress. CHIP upregulation and localization to mitochondria is required for mitochondrial autophagy (mitophagy)., [RefSeq, PubMed]; Rewiring of IGF1 secretion and enhanced IGF1R signaling induced by co-chaperone carboxyl-terminus of Hsp70 interacting protein in adipose-derived stem cells provide augmented cardioprotection in aging-hypertensive rats., [RefSeq, PubMed]; Silencing of STUB1 relieves osteoarthritis via inducing NRF2-mediated M2 macrophage polarization., [RefSeq, PubMed]; Study using two rodent models demonstrated that T246M mutation (described in autosomal recessive spinocerebellar ataxia-16 patients) results in structural disorganization and misfolding of the CHIP U-box domain, promoting oligomerization, and increased proteasome-dependent turnover. CHIP-T246M has no ligase activity but maintains interactions with chaperones and chaperone-related functions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D4A4T0", "ec_number_list": [], "go_molecular_function": "GO:0030911 TPR domain binding;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0051087 protein-folding chaperone binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0031943 regulation of glucocorticoid metabolic process;GO:0090035 positive regulation of chaperone-mediated protein complex assembly;GO:0061684 chaperone-mediated autophagy;GO:1901526 positive regulation of mitophagy;GO:0002931 response to ischemia", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A6HD62-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJS6-1", "uniprot_id": [ { "id": "MSPD1_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJS6", "type": "external" } ], "mass": 24088.0, "length": 213, "protein_name": "Motile sperm domain-containing protein 1", "gene_name": "Mospd1", "organism": "Rat", "refseq_name": "motile sperm domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001014129", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014129", "type": "external" } ], "gene_names_uniprotkb": "Mospd1; LOC686087; Mospd1l1", "gene_names_refseq": "Mospd1", "protein_names_uniprotkb": "Motile sperm domain-containing protein 1", "protein_names_refseq": "motile sperm domain-containing protein 1 isoform 1; motile sperm domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:317312)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RJS6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK62-1", "uniprot_id": [ { "id": "MPV17_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK62", "type": "external" } ], "mass": 19627.0, "length": 176, "protein_name": "Mitochondrial inner membrane protein Mpv17", "gene_name": "Mpv17", "organism": "Rat", "refseq_name": "mitochondrial inner membrane protein Mpv17", "refseq_ac": [ { "id": "NP_001091710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091710", "type": "external" } ], "gene_names_uniprotkb": "Mpv17; Mpv17l", "gene_names_refseq": "Mpv17l; Mpv17", "protein_names_uniprotkb": "Mitochondrial inner membrane protein Mpv17; Protein Mpv17", "protein_names_refseq": "MPV17 mitochondrial membrane protein-like; MpV17 mitochondrial inner membrane protein; Mpv17 transgene, kidney disease mutant-like; mitochondrial inner membrane protein Mpv17; protein Mpv17", "tax_id": 10116, "disease": "mitochondrial DNA depletion syndrome (Disease Ontology:DOID:0070329); mitochondrial DNA depletion syndrome 3 (Disease Ontology:DOID:0080121); mitochondrial DNA depletion syndrome 6 (Disease Ontology:DOID:0080125); Alport syndrome 2 (Disease Ontology:DOID:0110033); Charcot-Marie-Tooth disease type 2EE (Disease Ontology:DOID:0111559); nephrotic syndrome (Disease Ontology:DOID:1184); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (rno:360463); (R-RNO-9033241)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "26123482", "class_list": "", "function": "Mpv17 expression was increased after intracerebral hemorrhage., [RefSeq, PubMed]; Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis. Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance (By similarity). May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015267 channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005777 peroxisome;GO:0016020 membrane", "go_biological_process": "GO:0072593 reactive oxygen species metabolic process;GO:0048839 inner ear development;GO:0032836 glomerular basement membrane development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BK62-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85007-1", "uniprot_id": [ { "id": "IR3IP_RAT", "url": "https://www.uniprot.org/uniprot/P85007", "type": "external" } ], "mass": 8999.0, "length": 82, "protein_name": "Immediate early response 3-interacting protein 1", "gene_name": "Hdhd2; Ier3ip1", "organism": "Rat", "refseq_name": "immediate early response 3-interacting protein 1", "refseq_ac": [ { "id": "NP_001400957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001400957", "type": "external" } ], "gene_names_uniprotkb": "Hdhd2; Ier3ip1; Ier3ip1", "gene_names_refseq": "Ier3ip1", "protein_names_uniprotkb": "Immediate early response 3-interacting protein 1", "protein_names_refseq": "immediate early response 3-interacting protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:127566412)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size. Required for secretion of extracellular matrix proteins. Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors (By similarity). Acts as a regulator of the unfolded protein response (UPR) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:1901142 insulin metabolic process;GO:2000269 regulation of fibroblast apoptotic process;GO:0008285 negative regulation of cell population proliferation;GO:0015031 protein transport;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P85007-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2R0-1", "uniprot_id": [ { "id": "MAT2B_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2R0", "type": "external" } ], "mass": 37375.0, "length": 334, "protein_name": "Methionine adenosyltransferase 2 subunit beta", "gene_name": "Mat2b", "organism": "Rat", "refseq_name": "methionine adenosyltransferase 2 subunit beta", "refseq_ac": [ { "id": "NP_001037747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037747", "type": "external" } ], "gene_names_uniprotkb": "Mat2b", "gene_names_refseq": "Mat2b", "protein_names_uniprotkb": "Methionine adenosyltransferase 2 subunit beta; MAT II beta; Methionine adenosyltransferase II beta", "protein_names_refseq": "MAT II beta; methionine adenosyltransferase 2 beta subunit; methionine adenosyltransferase 2 subunit beta; methionine adenosyltransferase 2B; methionine adenosyltransferase II, beta", "tax_id": 10116, "disease": "", "pathway": " (rno:683630); (R-RNO-156581); (R-RNO-5689880)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "31686458;35287147", "class_list": "", "function": "Dexmedetomidine alleviates the hypoxic-ischemic brain damage via miR-20a-5p/methionine adenosyltransferase 2B axis in rat pups. Erratum:[Neuroreport. 2023 Aug 24;34(11):598. doi: 10.1097/WNR.0000000000001933. PMID: 37384939], [RefSeq, PubMed]; Investigated and confirmed protective effect of adipose-derived mesenchymal stem cells on miR-21-3p/methionine adenosyltransferase 2B (MAT2B) signal transduction in a rat ischemic brain injury model., [RefSeq, PubMed]; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0048269 methionine adenosyltransferase complex", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0006556 S-adenosylmethionine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5U2R0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVJ7-1", "uniprot_id": [ { "id": "IFT22_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVJ7", "type": "external" } ], "mass": 20848.0, "length": 185, "protein_name": "Intraflagellar transport protein 22 homolog", "gene_name": "Ift22", "organism": "Rat", "refseq_name": "intraflagellar transport protein 22 homolog", "refseq_ac": [ { "id": "NP_001011902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011902", "type": "external" } ], "gene_names_uniprotkb": "Ift22; Rabl5", "gene_names_refseq": "Ift22; Rabl5", "protein_names_uniprotkb": "Intraflagellar transport protein 22 homolog; Rab-like protein 5", "protein_names_refseq": "RAB, member RAS oncogene family-like 5; RAB, member of RAS oncogene family-like 5; intraflagellar transport 22 homolog; intraflagellar transport protein 22 homolog; rab-like protein 5", "tax_id": 10116, "disease": "", "pathway": " (rno:288585); (R-RNO-5620924)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Small GTPase-like component of the intraflagellar transport (IFT) complex B., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0012505 endomembrane system;GO:0030991 intraciliary transport particle A;GO:0030992 intraciliary transport particle B", "go_biological_process": "GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVJ7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIT1-1", "uniprot_id": [ { "id": "MARE3_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIT1", "type": "external" } ], "mass": 31966.0, "length": 281, "protein_name": "Microtubule-associated protein RP/EB family member 3", "gene_name": "Mapre3", "organism": "Rat", "refseq_name": "microtubule-associated protein RP/EB family member 3", "refseq_ac": [ { "id": "NP_001007657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007657", "type": "external" } ], "gene_names_uniprotkb": "Mapre3", "gene_names_refseq": "Mapre3", "protein_names_uniprotkb": "Microtubule-associated protein RP/EB family member 3; EB1 protein family member 3; EB3; EBF3; End-binding protein 3; RP3", "protein_names_refseq": "EB1 protein family member 3; EB3; EBF3; RP3; end-binding protein 3; microtubule-associated protein RP/EB family member 3", "tax_id": 10116, "disease": "", "pathway": " (rno:298848)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19146815;21248129;21551097;22673903;34478582", "class_list": "", "function": "EB3 and EB1 coordinate a molecular and functional interplay between ankyrin G (ankG)and the axon initial segment microtubules that supports the central role of ankG in the maintenance of neuronal polarity, [RefSeq, PubMed]; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive neuritogenesis in embryonic cortical neurons., [RefSeq, PubMed]; The interaction between PSD-95 and EB3 in determining dendritic morphology by regulation of microtubules elucidates a function for a novel region of EB3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0051010 microtubule plus-end binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0048471 perinuclear region of cytoplasm;GO:0051233 spindle midzone;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051301 cell division;GO:0045893 positive regulation of DNA-templated transcription;GO:0031113 regulation of microtubule polymerization;GO:0048148 behavioral response to cocaine", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5XIT1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62665-1", "uniprot_id": [ { "id": "LEG8_RAT", "url": "https://www.uniprot.org/uniprot/Q62665", "type": "external" } ], "mass": 36038.0, "length": 316, "protein_name": "Galectin-8", "gene_name": "Lgals8", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lgals8", "gene_names_refseq": "", "protein_names_uniprotkb": "Galectin-8; 30 kDa S-type lectin; Gal-8; RL-30", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7852431", "class_list": "", "function": "Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0031295 T cell costimulation;GO:0098792 xenophagy;GO:0098586 cellular response to virus;GO:0002317 plasma cell differentiation;GO:1904977 lymphatic endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62665-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FX1-1", "uniprot_id": [ { "id": "MPI_RAT", "url": "https://www.uniprot.org/uniprot/Q68FX1", "type": "external" } ], "mass": 46424.0, "length": 423, "protein_name": "Mannose-6-phosphate isomerase", "gene_name": "Mpi", "organism": "Rat", "refseq_name": "mannose-6-phosphate isomerase", "refseq_ac": [ { "id": "NP_001004081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004081", "type": "external" } ], "gene_names_uniprotkb": "Mpi", "gene_names_refseq": "Mpi", "protein_names_uniprotkb": "Mannose-6-phosphate isomerase; 5.3.1.8; PMI; Phosphohexomutase; Phosphomannose isomerase", "protein_names_refseq": "PMI; mannose-6-phosphate isomerase; phosphohexomutase; phosphomannose isomerase", "tax_id": 10116, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Ib (Disease Ontology:DOID:0080554); carbohydrate metabolic disorder (Disease Ontology:DOID:2978)", "pathway": " (rno:300741); (R-RNO-446205)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Isomerase that catalyzes the interconversion of fructose-6-P and mannose-6-P and has a critical role in the supply of D-mannose derivatives required for many eukaryotic glycosylation reactions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.8", "type": "external" } ], "go_molecular_function": "GO:0004476 mannose-6-phosphate isomerase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0061611 mannose to fructose-6-phosphate catabolic process;GO:0009298 GDP-mannose biosynthetic process;GO:0061729 GDP-D-mannose biosynthetic process from fructose-6-phosphate;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FX1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXQ8-1", "uniprot_id": [ { "id": "MNS1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXQ8", "type": "external" } ], "mass": 61240.0, "length": 498, "protein_name": "Meiosis-specific nuclear structural protein 1", "gene_name": "Mns1", "organism": "Rat", "refseq_name": "meiosis-specific nuclear structural protein 1", "refseq_ac": [ { "id": "NP_001007753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007753", "type": "external" } ], "gene_names_uniprotkb": "Mns1", "gene_names_refseq": "Mns1", "protein_names_uniprotkb": "Meiosis-specific nuclear structural protein 1", "protein_names_refseq": "meiosis-specific nuclear structural protein 1", "tax_id": 10116, "disease": "visceral heterotaxy 9 (Disease Ontology:DOID:0051023)", "pathway": " (rno:363093)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis (By similarity). Required for sperm flagella assembly (By similarity). May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005635 nuclear envelope;GO:0005929 cilium;GO:0031514 motile cilium;GO:0005882 intermediate filament", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0070986 left/right axis specification;GO:0051321 meiotic cell cycle;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXQ8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q499S5-1", "uniprot_id": [ { "id": "MMP11_RAT", "url": "https://www.uniprot.org/uniprot/Q499S5", "type": "external" } ], "mass": 55511.0, "length": 491, "protein_name": "Stromelysin-3", "gene_name": "Mmp11", "organism": "Rat", "refseq_name": "stromelysin-3 precursor", "refseq_ac": [ { "id": "NP_037112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037112", "type": "external" } ], "gene_names_uniprotkb": "Mmp11", "gene_names_refseq": "Mmp11; ST3", "protein_names_uniprotkb": "Stromelysin-3; 3.4.24.-; MMP-11; Matrix metalloproteinase-11; SL-3; ST3", "protein_names_refseq": "MMP-11; Matrix metalloproteinase 11 (stromelysin 3); SL-3; matrix metalloproteinase-11; stromelysin-3 precursor; stromelysin-3", "tax_id": 10116, "disease": "", "pathway": " (rno:25481); (R-RNO-1474228); (R-RNO-1592389)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "9055814", "class_list": "", "function": "May play an important role in the progression of epithelial malignancies., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97568", "ec_number_list": [ { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.24.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030199 collagen fibril organization;GO:0045599 negative regulation of fat cell differentiation;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q499S5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q561R9-1", "uniprot_id": [ { "id": "LACB2_RAT", "url": "https://www.uniprot.org/uniprot/Q561R9", "type": "external" } ], "mass": 32484.0, "length": 288, "protein_name": "Endoribonuclease LACTB2", "gene_name": "Lactb2", "organism": "Rat", "refseq_name": "endoribonuclease LACTB2", "refseq_ac": [ { "id": "NP_001019418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019418", "type": "external" } ], "gene_names_uniprotkb": "Lactb2", "gene_names_refseq": "Lactb2", "protein_names_uniprotkb": "Endoribonuclease LACTB2; 3.1.27.-; Beta-lactamase-like protein 2", "protein_names_refseq": "beta-lactamase-like protein 2; endoribonuclease LACTB2", "tax_id": 10116, "disease": "", "pathway": " (rno:297768)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0003727 single-stranded RNA binding;GO:0004521 RNA endonuclease activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005759 mitochondrial matrix;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q561R9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q562A2-1", "uniprot_id": [ { "id": "ZFR_RAT", "url": "https://www.uniprot.org/uniprot/Q562A2", "type": "external" } ], "mass": 116818.0, "length": 1073, "protein_name": "Zinc finger RNA-binding protein", "gene_name": "Zfr", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zfr", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger RNA-binding protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:365703)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15340146;16277607;16641100;17496889;18683930;21606357;22673903;38843836", "class_list": "", "function": "Involved in postimplantation and gastrulation stages of development (By similarity). Binds to DNA and RNA (By similarity). Involved in the nucleocytoplasmic shuttling of STAU2., [UniProtKB, PubMed]; Involved in postimplantation and gastrulation stages of development. Binds to DNA and RNA. Involved in the nucleocytoplasmic shuttling of STAU2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003725 double-stranded RNA binding;GO:0003727 single-stranded RNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q562A2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQX0-1", "uniprot_id": [ { "id": "UXS1_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQX0", "type": "external" } ], "mass": 47539.0, "length": 420, "protein_name": "UDP-glucuronic acid decarboxylase 1", "gene_name": "Uxs1", "organism": "Rat", "refseq_name": "UDP-glucuronic acid decarboxylase 1", "refseq_ac": [ { "id": "NP_647552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647552", "type": "external" } ], "gene_names_uniprotkb": "Uxs1", "gene_names_refseq": "UGD; Uxs1", "protein_names_uniprotkb": "UDP-glucuronic acid decarboxylase 1; 4.1.1.35; UDP-glucuronate decarboxylase 1; UGD; UXS-1", "protein_names_refseq": "UDP-glucuronic acid decarboxylase 1; UXS-1", "tax_id": 10116, "disease": "", "pathway": " (rno:246232); (R-RNO-173599); (R-RNO-1971475)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "11877387", "class_list": "", "function": "Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose (PubMed:11877387). Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (PubMed:11877387). Catalyzes the synthesis of UDP-xylose in two steps: the hydroxyl group of UDP-glucuronic acid is first oxidized using an enzyme-bound NAD(+) as electron acceptor, favoring the decarboxylation yielding a UDP-4-ketoxylose reaction intermediate and a reduced cofactor NADH bound to the catalytic pocket (By similarity). In the second step, the 4-keto group is reduced resulting in UDP-xylose and the restoration of the enzyme to its NAD(+)-bound form (By similarity)., [UniProtKB, PubMed, UniProtKB]; Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis. Catalyzes the synthesis of UDP-xylose in two steps: the hydroxyl group of UDP-glucuronic acid is first oxidized using an enzyme-bound NAD(+) as electron acceptor, favoring the decarboxylation yielding a UDP-4-ketoxylose reaction intermediate and a reduced cofactor NADH bound to the catalytic pocket. In the second step, the 4-keto group is reduced resulting in UDP-xylose and the restoration of the enzyme to its NAD(+)-bound form., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K464", "ec_number_list": [ { "id": "4.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.35", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0070403 NAD+ binding;GO:0048040 UDP-glucuronate decarboxylase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0042732 D-xylose metabolic process;GO:0006024 glycosaminoglycan biosynthetic process;GO:0033320 UDP-D-xylose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PQX0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61131-1", "uniprot_id": [ { "id": "SIA4C_RAT", "url": "https://www.uniprot.org/uniprot/P61131", "type": "external" } ], "mass": 38043.0, "length": 333, "protein_name": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4", "gene_name": "Dcps; St3gal4", "organism": "Rat", "refseq_name": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 4 isoform 1", "refseq_ac": [ { "id": "NP_976082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_976082", "type": "external" } ], "gene_names_uniprotkb": "Dcps; St3gal4; Dcps; Siat4c", "gene_names_refseq": "SIAT4-C; ST3GalIV; St3gal4; siat4c", "protein_names_uniprotkb": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4; 2.4.3.2; 2.4.3.4; 2.4.3.6; Alpha 2,3-ST 4; Alpha 2,3-sialyltransferase IV; Beta-galactoside alpha-2,3-sialyltransferase 4; Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; Gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase; N-acetyllactosaminide alpha-2,3-sialyltransferase; SIAT4-C; ST3Gal IV; ST3GalIV; Sialyltransferase 4C", "protein_names_refseq": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 4 isoform 1; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 3-sialyltransferase 4; N-acetyllactosaminide alpha-2,3-sialyltransferase; alpha 2,3-sialyltransferase IV; alpha-2,3-sialyltransferase ST3Gal IV; beta-galactoside alpha-2,3-sialyltransferase 4; gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase; gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase; sialyltransferase 4C", "tax_id": 10116, "disease": "", "pathway": " (rno:363040); (R-RNO-2022854); (R-RNO-4085001); (R-RNO-9037629); (R-RNO-975577); (R-RNO-977068)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "7798936", "class_list": "glycogene;glycosyltransferase", "function": "A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids. Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage (By similarity). Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets (By similarity). Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation (By similarity). Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2 (By similarity). In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively (By similarity). Metabolizes brain c-series ganglioside GT1c forming GQ1c (Probable). Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.2", "type": "external" }, { "id": "2.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.4", "type": "external" }, { "id": "3.6.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.59", "type": "external" }, { "id": "2.4.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.6", "type": "external" }, { "id": "3.6.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.52", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.6.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.10", "type": "external" }, { "id": "3.6.1.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.61", "type": "external" }, { "id": "2.4.3.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.9", "type": "external" } ], "go_molecular_function": "GO:0047288 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase;GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity;GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity;GO:0008373 sialyltransferase activity;GO:0140932 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane;GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0050890 cognition;GO:0009101 glycoprotein biosynthetic process;GO:0009247 glycolipid biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 2417, "hit_score": 0.2, "record_id": "P61131-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63285-1", "uniprot_id": [ { "id": "UHMK1_RAT", "url": "https://www.uniprot.org/uniprot/Q63285", "type": "external" } ], "mass": 46505.0, "length": 419, "protein_name": "Serine/threonine-protein kinase Kist", "gene_name": "Uhmk1", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase Kist", "refseq_ac": [ { "id": "NP_058989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058989", "type": "external" } ], "gene_names_uniprotkb": "Uhmk1; Kist; Kis; LOC134482856; Uhmk1l1", "gene_names_refseq": "KIS; Kist; Uhmk1", "protein_names_uniprotkb": "Serine/threonine-protein kinase Kist; 2.7.11.1; Kinase interacting with stathmin; P-CIP2; PAM COOH-terminal interactor protein 2; U2AF homology motif kinase 1", "protein_names_refseq": "P-CIP2; PAM COOH-terminal interactor protein 2; U2AF homology motif (UHM) kinase 1; kinase interacting stathmin; kinase interacting with leukemia-associated gene (stathmin); kinase interacting with stathmin; serine/threonine-protein kinase Kist", "tax_id": 10116, "disease": "", "pathway": " (rno:246332); (R-RNO-9634638)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18588901;8910496;9287318", "class_list": "", "function": "KIS presents a different specificity for the UHM docking sites that are present in the N-terminal region of SF3b155, thus providing a new insight into the variety of interactions mediated by UHM domains., [RefSeq, PubMed]; Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030424 axon;GO:0032839 dendrite cytoplasm", "go_biological_process": "GO:0031175 neuron projection development;GO:0018105 peptidyl-serine phosphorylation;GO:0046825 regulation of protein export from nucleus;GO:0051726 regulation of cell cycle;GO:0045948 positive regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63285-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2S5-1", "uniprot_id": [ { "id": "SNX24_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2S5", "type": "external" } ], "mass": 19653.0, "length": 169, "protein_name": "Sorting nexin-24", "gene_name": "Snx24", "organism": "Rat", "refseq_name": "sorting nexin-24", "refseq_ac": [ { "id": "NP_001008365", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008365", "type": "external" } ], "gene_names_uniprotkb": "Snx24", "gene_names_refseq": "Snx24", "protein_names_uniprotkb": "Sorting nexin-24", "protein_names_refseq": "SBBI31 protein; sorting nexin-24; sorting nexing 24", "tax_id": 10116, "disease": "", "pathway": " (rno:361328)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in several stages of intracellular trafficking., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2S5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KR59-1", "uniprot_id": [ { "id": "UBP10_RAT", "url": "https://www.uniprot.org/uniprot/Q3KR59", "type": "external" } ], "mass": 87311.0, "length": 794, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 10", "gene_name": "Usp10", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 10 isoform 1", "refseq_ac": [ { "id": "NP_001029318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029318", "type": "external" } ], "gene_names_uniprotkb": "Usp10", "gene_names_refseq": "Usp10", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 10; 3.4.19.12; Deubiquitinating enzyme 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10", "protein_names_refseq": "deubiquitinating enzyme 10; ubiquitin carboxyl-terminal hydrolase 10 isoform 1; ubiquitin carboxyl-terminal hydrolase 10; ubiquitin specific protease 10; ubiquitin thioesterase 10; ubiquitin thiolesterase 10; ubiquitin-specific-processing protease 10", "tax_id": 10116, "disease": "", "pathway": " (rno:307905); (R-RNO-5656169); (R-RNO-5689880)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB, UniProtKB]; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits. Acts as a negative regulator of stress granules formation by lowering G3BP1 and G3BP2 valence, thereby preventing G3BP1 and G3BP2 ability to undergo liquid-liquid phase separation (LLPS) and assembly of stress granules. Promotes 40S ribosome subunit recycling following ribosome dissociation in response to ribosome stalling by mediating deubiquitination of 40S ribosomal proteins RPS2/us5, RPS3/us3 and RPS10/eS10, thereby preventing their degradation by the proteasome. Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappa-B activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Deubiquitinates TBX21 leading to its stabilization. Plays a negative role in the RLR signaling pathway upon RNA virus infection by blocking the RIGI-mediated MAVS activation. Mechanistically, removes the unanchored 'Lys-63'-linked polyubiquitin chains of MAVS to inhibit its aggregation, essential for its activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0002039 p53 binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0006281 DNA repair;GO:0006508 proteolysis;GO:0010506 regulation of autophagy;GO:0016579 protein deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3KR59-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83868-1", "uniprot_id": [ { "id": "TEBP_RAT", "url": "https://www.uniprot.org/uniprot/P83868", "type": "external" } ], "mass": 18721.0, "length": 160, "protein_name": "Prostaglandin E synthase 3", "gene_name": "Ptges3", "organism": "Rat", "refseq_name": "prostaglandin E synthase 3", "refseq_ac": [ { "id": "NP_001124461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124461", "type": "external" } ], "gene_names_uniprotkb": "Ptges3; Tebp", "gene_names_refseq": "Ptges3; RGD1561913", "protein_names_uniprotkb": "Prostaglandin E synthase 3; 5.3.99.3; Cytosolic prostaglandin E2 synthase; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23; cPGES", "protein_names_refseq": "cPGES; cytosolic prostaglandin E2 synthase; hsp90 co-chaperone; progesterone receptor complex p23; prostaglandin E synthase 3 (cytosolic); prostaglandin E synthase 3; telomerase-binding protein p23", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612); atherosclerosis (Disease Ontology:DOID:1936); oligodendroglioma (Disease Ontology:DOID:3181)", "pathway": " (rno:362809); (R-RNO-2162123); (R-RNO-3371497); (R-RNO-3371511); (R-RNO-3371568); (R-RNO-8937144); (R-RNO-8939211); (R-RNO-9018519)", "pathway_count": 8, "publication_count": 4, "publication_id_list": "10922363;16641100;22673903;29093345", "class_list": "", "function": "Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study in cultured rat fibroblasts suggests that cPGES/p23 is involved in the activation of ERK to promote c-Fos expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0070182 DNA polymerase binding;GO:0051879 Hsp90 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005884 actin filament;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0008283 cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0051402 neuron apoptotic process;GO:0042921 nuclear receptor-mediated glucocorticoid signaling pathway;GO:0032212 positive regulation of telomere maintenance via telomerase", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P83868-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61078-1", "uniprot_id": [ { "id": "UB2D3_RAT", "url": "https://www.uniprot.org/uniprot/P61078", "type": "external" } ], "mass": 16687.0, "length": 147, "protein_name": "Ubiquitin-conjugating enzyme E2 D3", "gene_name": "Ube2d2; Ube2d3", "organism": "Rat", "refseq_name": "ubiquitin-conjugating enzyme E2 D3", "refseq_ac": [ { "id": "NP_112516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112516", "type": "external" } ], "gene_names_uniprotkb": "Ube2d2; Ube2d3; Ube2d2", "gene_names_refseq": "Ube2d3", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 D3; (E3-independent) E2 ubiquitin-conjugating enzyme D3; 2.3.2.23; 2.3.2.24; E2 ubiquitin-conjugating enzyme D3; PAPase; Phosphoarginine phosphatase; Ubiquitin carrier protein D3; Ubiquitin-conjugating enzyme E2(17)KB 3; Ubiquitin-conjugating enzyme E2-17 kDa 3; Ubiquitin-protein ligase D3", "protein_names_refseq": "(E3-independent) E2 ubiquitin-conjugating enzyme D3; E2 ubiquitin-conjugating enzyme D3; E2(17)KB 3; PAPase; phosphoarginine phosphatase; ubiquitin carrier protein D3; ubiquitin-conjugating enzyme E2 D3; ubiquitin-conjugating enzyme E2(17)KB 3; ubiquitin-conjugating enzyme E2-17 kDa 3; ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5); ubiquitin-protein ligase D3", "tax_id": 10116, "disease": "", "pathway": " (rno:81920); (R-RNO-1234176); (R-RNO-201451); (R-RNO-2173795); (R-RNO-5205685); (R-RNO-5357905); (R-RNO-8866654); (R-RNO-8951664); (R-RNO-9033241); (R-RNO-937041); (R-RNO-9705462); (R-RNO-983168); (R-RNO-9954716)", "pathway_count": 13, "publication_count": 2, "publication_id_list": "34391873;7826319", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Also acts as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production. Together with ZNF598, catalyzes ubiquitination of 40S ribosomal proteins in response to ribosome collisions. In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2., [UniProtKB, UniProtKB]; UBE2D3 contributes to myocardial ischemia-reperfusion injury by regulating autophagy in dependence of p62/SQSTM1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P47986", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "1.14.11.29", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.29", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006281 DNA repair;GO:0006915 apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0070979 protein K11-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P61078-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32PZ3-1", "uniprot_id": [ { "id": "UN45A_RAT", "url": "https://www.uniprot.org/uniprot/Q32PZ3", "type": "external" } ], "mass": 103241.0, "length": 944, "protein_name": "Protein unc-45 homolog A", "gene_name": "Unc45a", "organism": "Rat", "refseq_name": "protein unc-45 homolog A", "refseq_ac": [ { "id": "NP_001032736", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032736", "type": "external" } ], "gene_names_uniprotkb": "Unc45a; Smap1", "gene_names_refseq": "RGD1305357; Unc45a", "protein_names_uniprotkb": "Protein unc-45 homolog A; SMAP-1; Smooth muscle cell-associated protein 1; Unc-45A", "protein_names_refseq": "SMAP-1; UNC-45A; protein unc-45 homolog A; smooth muscle cell-associated protein 1; unc-45 homolog A", "tax_id": 10116, "disease": "", "pathway": " (rno:308759)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as co-chaperone for HSP90 (Potential). Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell (By similarity). May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity)., [UniProtKB]; May act as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin. Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051879 Hsp90 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0048471 perinuclear region of cytoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0030154 cell differentiation;GO:0007517 muscle organ development;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32PZ3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TGJ1-1", "uniprot_id": [ { "id": "ZDH18_RAT", "url": "https://www.uniprot.org/uniprot/Q2TGJ1", "type": "external" } ], "mass": 41659.0, "length": 386, "protein_name": "Palmitoyltransferase ZDHHC18", "gene_name": "Zdhhc18", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zdhhc18", "gene_names_refseq": "", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC18; 2.3.1.225; Zinc finger DHHC domain-containing protein 18", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:362613)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK. Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS. May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0006612 protein targeting to membrane;GO:0008104 intracellular protein localization;GO:0045824 negative regulation of innate immune response;GO:0018230 peptidyl-L-cysteine S-palmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TGJ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U211-1", "uniprot_id": [ { "id": "SNX3_RAT", "url": "https://www.uniprot.org/uniprot/Q5U211", "type": "external" } ], "mass": 18762.0, "length": 162, "protein_name": "Sorting nexin-3", "gene_name": "Snx3", "organism": "Rat", "refseq_name": "sorting nexin-3", "refseq_ac": [ { "id": "NP_001037748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037748", "type": "external" } ], "gene_names_uniprotkb": "Snx3", "gene_names_refseq": "Snx3", "protein_names_uniprotkb": "Sorting nexin-3", "protein_names_refseq": "sorting nexin-3", "tax_id": 10116, "disease": "", "pathway": " (rno:684097); (R-RNO-3238698); (R-RNO-5689880)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC). May act in part as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes. Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor Tfrc presuambly by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex. Involved in regulation of neurite outgrowth in primary neurons. Required for trafficking of WLS to the early endosome for recycling which promotes both canonical and non-canonical WNT signaling and is essential for neural tube closure., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0019903 protein phosphatase binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0031901 early endosome membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0010324 membrane invagination;GO:0010976 positive regulation of neuron projection development;GO:0009617 response to bacterium;GO:0030111 regulation of Wnt signaling pathway;GO:0042177 negative regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U211-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97689-1", "uniprot_id": [ { "id": "UT1_RAT", "url": "https://www.uniprot.org/uniprot/P97689", "type": "external" } ], "mass": 42034.0, "length": 384, "protein_name": "Urea transporter 1", "gene_name": "Slc14a1", "organism": "Rat", "refseq_name": "urea transporter 1", "refseq_ac": [ { "id": "NP_062219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062219", "type": "external" } ], "gene_names_uniprotkb": "Slc14a1; UT11; UT3", "gene_names_refseq": "HUT11; Slc14a1; UT-B; UT3; UTB1; UrT2", "protein_names_uniprotkb": "Urea transporter 1; Solute carrier family 14 member 1; UT-B; Urea transporter B; Urea transporter, erythrocyte", "protein_names_refseq": "solute carrier family 14 (urea transporter), member 1 (Kidd blood group); urea transporter 1; urea transporter B; urea transporter, erythrocyte", "tax_id": 10116, "disease": "limb ischemia (Disease Ontology:DOID:0050852); atypical chronic myeloid leukemia, BCR-ABL1 negative (Disease Ontology:DOID:0060597); myeloid neoplasm (Disease Ontology:DOID:0070004); bone disease (Disease Ontology:DOID:0080001); T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0081312); hypogonadotropic hypogonadism 7 with or without anosmia (Disease Ontology:DOID:0090078); hypogonadotropic hypogonadism 2 with or without anosmia (Disease Ontology:DOID:0090083); Jackson-Weiss syndrome (Disease Ontology:DOID:0111337); osteoglophonic dysplasia (Disease Ontology:DOID:0111532); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); otitis media (Disease Ontology:DOID:10754); sciatic neuropathy (Disease Ontology:DOID:11446); acoustic neuroma (Disease Ontology:DOID:12689); acrocephalosyndactylia (Disease Ontology:DOID:12960); Pfeiffer syndrome (Disease Ontology:DOID:14705); transient cerebral ischemia (Disease Ontology:DOID:224); high grade glioma (Disease Ontology:DOID:3070); lung non-small cell carcinoma (Disease Ontology:DOID:3908); mouth disease (Disease Ontology:DOID:403); renal cell carcinoma (Disease Ontology:DOID:4450); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); fibrolamellar carcinoma (Disease Ontology:DOID:5015); retinal detachment (Disease Ontology:DOID:5327); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398); myeloid leukemia (Disease Ontology:DOID:8692); vascular dementia (Disease Ontology:DOID:8725); acute myeloid leukemia (Disease Ontology:DOID:9119); cleft lip (Disease Ontology:DOID:9296); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:54301); (R-RNO-549127)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "23486518;25613743;25869070;26414230;8982255", "class_list": "", "function": "Mediates the transport of urea driven by a concentration gradient across the cell membrane (PubMed:8982255). Mediates the transport of urea across the cell membranes of erythrocytes and the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity). Facilitates water transport in erythrocytes (By similarity)., [UniProtKB, UniProtKB, PubMed]; Report thiourea analogs as inhibitors of UT-B mediated urea transport., [RefSeq, PubMed]; Thienoquinoline PU-14 is a selective UT inhibitor and has urea-selective diuretic activity., [RefSeq, PubMed]; UT-B expression in the choroid plexus was reduced by high salt diet., [RefSeq, PubMed]; Urea Transporter Protein is abnormally expressed in a rat model of hepatorenal syndrome induced by succinylated gelatin Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 33, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9PSP0;P70633", "ec_number_list": [], "go_molecular_function": "GO:0005372 water transmembrane transporter activity;GO:0015265 urea channel activity;GO:0015204 urea transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0071918 urea transmembrane transport;GO:0006833 water transport;GO:0015840 urea transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P97689-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XHY5-1", "uniprot_id": [ { "id": "SYTC_RAT", "url": "https://www.uniprot.org/uniprot/Q5XHY5", "type": "external" } ], "mass": 80576.0, "length": 695, "protein_name": "Threonine--tRNA ligase 1, cytoplasmic", "gene_name": "Tars1", "organism": "Rat", "refseq_name": "threonine--tRNA ligase 1, cytoplasmic isoform 2", "refseq_ac": [ { "id": "NP_001006977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006977", "type": "external" } ], "gene_names_uniprotkb": "Tars1; Tars", "gene_names_refseq": "Tars1; Tars", "protein_names_uniprotkb": "Threonine--tRNA ligase 1, cytoplasmic; 6.1.1.3; ThrRS; Threonine--tRNA ligase, cytoplasmic; Threonyl-tRNA synthetase 1; Threonyl-tRNA synthetase", "protein_names_refseq": "thrRS; threonine--tRNA ligase 1, cytoplasmic isoform 2; threonine--tRNA ligase 1, cytoplasmic; threonine--tRNA ligase, cytoplasmic; threonyl-tRNA synthetase, cytoplasmic", "tax_id": 10116, "disease": "nonphotosensitive trichothiodystrophy (Disease Ontology:DOID:0111867); nonphotosensitive trichothiodystrophy 7 (Disease Ontology:DOID:0111870); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (rno:294810)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0004829 threonine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006435 threonyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XHY5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWU4-1", "uniprot_id": [ { "id": "ZBT44_RAT", "url": "https://www.uniprot.org/uniprot/Q3SWU4", "type": "external" } ], "mass": 50277.0, "length": 453, "protein_name": "Zinc finger and BTB domain-containing protein 44", "gene_name": "Zbtb44", "organism": "Rat", "refseq_name": "zinc finger and BTB domain-containing protein 44 isoform 1", "refseq_ac": [ { "id": "NP_001030114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030114", "type": "external" } ], "gene_names_uniprotkb": "Zbtb44; Btbd15", "gene_names_refseq": "Btbd15; RGD1308984; Zbtb44", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 44; BTB/POZ domain-containing protein 15", "protein_names_refseq": "BTB (POZ) domain containing 15; BTB/POZ domain-containing protein 15; zinc finger and BTB domain-containing protein 44 isoform 1; zinc finger and BTB domain-containing protein 44", "tax_id": 10116, "disease": "", "pathway": " (rno:363035)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3SWU4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U3Y5-1", "uniprot_id": [ { "id": "SFT2A_RAT", "url": "https://www.uniprot.org/uniprot/Q5U3Y5", "type": "external" } ], "mass": 17887.0, "length": 159, "protein_name": "Vesicle transport protein SFT2A", "gene_name": "Sft2d1", "organism": "Rat", "refseq_name": "vesicle transport protein SFT2A", "refseq_ac": [ { "id": "NP_001008303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008303", "type": "external" } ], "gene_names_uniprotkb": "Sft2d1", "gene_names_refseq": "Sft2d1", "protein_names_uniprotkb": "Vesicle transport protein SFT2A; SFT2 domain-containing protein 1", "protein_names_refseq": "SFT2 domain-containing protein 1; vesicle transport protein SFT2A", "tax_id": 10116, "disease": "", "pathway": " (rno:292305)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U3Y5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HA4-1", "uniprot_id": [ { "id": "TAXB1_RAT", "url": "https://www.uniprot.org/uniprot/Q66HA4", "type": "external" } ], "mass": 93197.0, "length": 813, "protein_name": "Tax1-binding protein 1 homolog", "gene_name": "Tax1bp1", "organism": "Rat", "refseq_name": "tax1-binding protein 1 homolog", "refseq_ac": [ { "id": "NP_001004199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004199", "type": "external" } ], "gene_names_uniprotkb": "Tax1bp1; Aa1076", "gene_names_refseq": "Aa1076; Tax1bp1", "protein_names_uniprotkb": "Tax1-binding protein 1 homolog; Liver regeneration-related protein LRRG004", "protein_names_refseq": "TRAF6-binding protein homolog; Tax1 (human T-cell leukemia virus type I) binding protein 1; liver regeneration-related protein 2; liver regeneration-related protein LRRG004; tax1-binding protein 1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:246244); (R-RNO-5357905); (R-RNO-936440)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "16999686;22695963;33207181", "class_list": "", "function": "C-terminal region of Tax1BP1 bound to an intracellular domain of the rho1 subunit, but not to other subunits of GABA(C), GABA(A) or glycine receptors. Tax1BP1 & GABA(C) receptors were co-expressed in both synaptic layers of the retina., [RefSeq, PubMed]; Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain. Erratum:[Mol Cell. 2022 Apr 7;82(7):1383-1385. doi: 10.1016/j.molcel.2022.03.020. PMID: 35395199], [RefSeq, PubMed]; The increased expression of Tax1BP1 in optic nerve crush eyes displays the possible neuroprotective effect of bone marrow mononuclear cell treatment Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation. Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates. Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production. Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways. Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling. As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis. Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation. Mediates the autophagic degradation of other substrates including TICAM1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQ13", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0019900 kinase binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome;GO:0000407 phagophore assembly site", "go_biological_process": "GO:2000660 negative regulation of interleukin-1-mediated signaling pathway;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q66HA4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI22-1", "uniprot_id": [ { "id": "THIC_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI22", "type": "external" } ], "mass": 41108.0, "length": 397, "protein_name": "Acetyl-CoA acetyltransferase, cytosolic", "gene_name": "Acat2", "organism": "Rat", "refseq_name": "acetyl-CoA acetyltransferase, cytosolic", "refseq_ac": [ { "id": "NP_001006996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006996", "type": "external" } ], "gene_names_uniprotkb": "Acat2", "gene_names_refseq": "Ab2-076; Acat2; Acat3", "protein_names_uniprotkb": "Acetyl-CoA acetyltransferase, cytosolic; 2.3.1.9; Cytosolic acetoacetyl-CoA thiolase", "protein_names_refseq": "acetyl-CoA acetyltransferase, cytosolic; acetyl-Coenzyme A acetyltransferase 2; acetyl-Coenzyme A acetyltransferase 3; cytosolic acetoacetyl-CoA thiolase", "tax_id": 10116, "disease": "coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (rno:308100); (R-RNO-9969896)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "27809850", "class_list": "", "function": "Involved in the biosynthetic pathway of cholesterol., [UniProtKB, UniProtKB]; The increased H3K27me3 expression might cause a disorder of folate metabolic pathway by silencing ACat2 expression, leading to reduced proliferation and differentiation of neural stem cells, and ultimately the occurrence of neural tube defects. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" } ], "go_molecular_function": "GO:0003985 acetyl-CoA C-acetyltransferase activity;GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0031670 cellular response to nutrient;GO:0001889 liver development;GO:0006631 fatty acid metabolic process;GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0033386 geranylgeranyl diphosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XI22-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKL5-1", "uniprot_id": [ { "id": "STEA3_RAT", "url": "https://www.uniprot.org/uniprot/Q5RKL5", "type": "external" } ], "mass": 54674.0, "length": 488, "protein_name": "Metalloreductase STEAP3", "gene_name": "Steap3", "organism": "Rat", "refseq_name": "metalloreductase STEAP3", "refseq_ac": [ { "id": "NP_579848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579848", "type": "external" } ], "gene_names_uniprotkb": "Steap3", "gene_names_refseq": "Steap3", "protein_names_uniprotkb": "Metalloreductase STEAP3; 1.16.1.-; Six-transmembrane epithelial antigen of prostate 3; pHyde", "protein_names_refseq": "STEAP family member 3, metalloreductase; metalloreductase STEAP3; pHyde; six-transmembrane epithelial antigen of prostate 3; tumor suppressor pHyde", "tax_id": 10116, "disease": "", "pathway": " (rno:170824); (R-RNO-6803204); (R-RNO-9013406); (R-RNO-9035034); (R-RNO-917977)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10969787;11593405;22673903;37820423", "class_list": "", "function": "Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (By similarity). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity). Mediates efficient transferrin-dependent iron uptake in erythroid cells (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression (PubMed:11593405). Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; Research of STEAP3 interaction with Rab7A and RACK1 to modulate the MAPK and JAK/STAT signaling in Osteoarthritis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99P41", "ec_number_list": [ { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "1.16.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0071949 FAD binding;GO:0020037 heme binding;GO:0008823 cupric reductase (NADH) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0010008 endosome membrane;GO:0005771 multivesicular body", "go_biological_process": "GO:1990182 exosomal secretion;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0009306 protein secretion;GO:0015677 copper ion import", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5RKL5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62961-1", "uniprot_id": [ { "id": "YBOX1_RAT", "url": "https://www.uniprot.org/uniprot/P62961", "type": "external" } ], "mass": 35730.0, "length": 322, "protein_name": "Y-box-binding protein 1", "gene_name": "Ybx1", "organism": "Rat", "refseq_name": "Y-box-binding protein 1 isoform 2", "refseq_ac": [ { "id": "NP_113751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113751", "type": "external" } ], "gene_names_uniprotkb": "Ybx1; Yb1", "gene_names_refseq": "Byb1; CBF-A; Cbfa; Dbpb; EFI-A; Ef1a; Msy1; Nsep1; YB-1; Yb1; Ybx1", "protein_names_uniprotkb": "Y-box-binding protein 1; EFI-A; Enhancer factor I subunit A; Nuclease-sensitive element-binding protein 1; Y-box transcription factor; YB-1", "protein_names_refseq": "CCAAT-binding transcription factor 1 subunit A; CCAAT-binding transcription factor I subunit A; DNA binding protein B; Y box transcription factor; Y-box-binding protein 1 isoform 2; enhancer factor 1 alpha; enhancer factor 1 subunit A; enhancer factor I subunit A; nuclease-sensitive element-binding protein 1", "tax_id": 10116, "disease": "Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:500538); (R-RNO-72163); (R-RNO-72165); (R-RNO-72203); (R-RNO-877300); (R-RNO-9017802); (R-RNO-9770562)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "12010125;12554649;12835324;1967130;31967332;35151240;35255737;38700571", "class_list": "", "function": "DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation. Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay. Component of the CRD-mediated complex that promotes MYC mRNA stability (By similarity). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs. Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs. Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs. Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection. Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair. The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data show that Y box-binding protein-1 (YB-1) is a regulator of protein tyrosine phosphatase 1B (PTP1B) expression, and highlight PTP1B as a critical regulator of insulin- and cytokine-mediated signal transduction., [RefSeq, PubMed]; Exosomal YB-1 facilitates ovarian restoration by MALAT1/miR-211-5p/FOXO3 axis. Publication Status: Online-Only, [RefSeq, PubMed]; May protect cells from p53-mediated apoptosis, [RefSeq, PubMed]; MiR-379-5p Promotes Chondrocyte Proliferation via Inhibition of PI3K/Akt Pathway by Targeting YBX1 in Osteoarthritis., [RefSeq, PubMed]; Nm23-beta binds to YB-1 and inhibits MMP2 transcription, [RefSeq, PubMed]; Y-box protein 1 promotes hypoxia/reoxygenation- or ischemia/reperfusion-induced cardiomyocyte apoptosis via SHP-1-dependent STAT3 inactivation., [RefSeq, PubMed]; YBX1 Protects against Apoptosis Induced by Oxygen-Glucose Deprivation/Reoxygenation in PC12 Cells via Activation of the AKT/GSK3beta Pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P22568;P27817;P43482;Q4KMA4", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003676 nucleic acid binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0071204 histone pre-mRNA 3'end processing complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:1903608 protein localization to cytoplasmic stress granule;GO:0070934 CRD-mediated mRNA stabilization;GO:2000767 positive regulation of cytoplasmic translation;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P62961-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62671-1", "uniprot_id": [ { "id": "UBR5_RAT", "url": "https://www.uniprot.org/uniprot/Q62671", "type": "external" } ], "mass": 308027.0, "length": 2788, "protein_name": "E3 ubiquitin-protein ligase UBR5", "gene_name": "Ubr5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ubr5; Dd5; Edd1; Edd; Hyd", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase UBR5; 100 kDa protein; 2.3.2.26; E3 ubiquitin-protein ligase, HECT domain-containing 1; HECT-type E3 ubiquitin transferase UBR5; Hyperplastic discs protein homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); laryngeal carcinoma (Disease Ontology:DOID:2600); invasive ductal carcinoma (Disease Ontology:DOID:3008); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); gallbladder carcinoma (Disease Ontology:DOID:4948)", "pathway": " (rno:117060)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10030672;12239083;1533713;22673903;26224628", "class_list": "", "function": "E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (By similarity). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (By similarity). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (By similarity). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (By similarity). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (By similarity). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (By similarity). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (By similarity). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (By similarity). Ubiquitinates acetylated PCK1 (By similarity). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (By similarity). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (By similarity). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 33, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1LRS0", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0061630 ubiquitin protein ligase activity;GO:0034450 ubiquitin-ubiquitin ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0032700 negative regulation of interleukin-17 production;GO:0006281 DNA repair;GO:0010628 positive regulation of gene expression;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62671-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJN5-1", "uniprot_id": [ { "id": "MIA40_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJN5", "type": "external" } ], "mass": 15467.0, "length": 139, "protein_name": "Mitochondrial intermembrane space import and assembly protein 40", "gene_name": "Chchd4", "organism": "Rat", "refseq_name": "mitochondrial intermembrane space import and assembly protein 40", "refseq_ac": [ { "id": "NP_001013449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013449", "type": "external" } ], "gene_names_uniprotkb": "Chchd4; Chchd4-ps1; LOC100361898; Mia40", "gene_names_refseq": "Chchd4", "protein_names_uniprotkb": "Mitochondrial intermembrane space import and assembly protein 40; Coiled-coil-helix-coiled-coil-helix domain-containing protein 4", "protein_names_refseq": "coiled-coil-helix-coiled-coil-helix domain-containing protein 4; mitochondrial intermembrane space import and assembly protein 40", "tax_id": 10116, "disease": "", "pathway": " (rno:312559)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "37438854", "class_list": "", "function": "Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes. Functions as a chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COA7, COX17, COX19, MICU1 and TIMCC/FAM136A. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Required for the import of COA7 in the IMS. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system. Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake., [UniProtKB, UniProtKB]; Elevated CHCHD4 orchestrates mitochondrial oxidative phosphorylation to disturb hypoxic pulmonary hypertension. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015035 protein-disulfide reductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0045041 protein import into mitochondrial intermembrane space;GO:0033108 mitochondrial respiratory chain complex assembly;GO:1990830 cellular response to leukemia inhibitory factor;GO:0034599 cellular response to oxidative stress;GO:0072655 establishment of protein localization to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BJN5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H56-1", "uniprot_id": [ { "id": "TTI2_RAT", "url": "https://www.uniprot.org/uniprot/Q66H56", "type": "external" } ], "mass": 56436.0, "length": 511, "protein_name": "TELO2-interacting protein 2", "gene_name": "Tti2", "organism": "Rat", "refseq_name": "TELO2-interacting protein 2", "refseq_ac": [ { "id": "NP_001013905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013905", "type": "external" } ], "gene_names_uniprotkb": "Tti2", "gene_names_refseq": "RGD1310414; Tti2", "protein_names_uniprotkb": "TELO2-interacting protein 2", "protein_names_refseq": "TELO2-interacting protein 2; Tel2 interacting protein 2 homolog; uncharacterized protein C8orf41 homolog", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 39 (Disease Ontology:DOID:0081204)", "pathway": " (rno:290811)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29393594;35377872", "class_list": "", "function": "Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs (By similarity)., [UniProtKB]; Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0110078 TTT Hsp90 cochaperone complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q66H56-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK48-1", "uniprot_id": [ { "id": "TTC5_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK48", "type": "external" } ], "mass": 48793.0, "length": 440, "protein_name": "Tetratricopeptide repeat protein 5", "gene_name": "Ttc5", "organism": "Rat", "refseq_name": "tetratricopeptide repeat protein 5", "refseq_ac": [ { "id": "NP_001013149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013149", "type": "external" } ], "gene_names_uniprotkb": "Ttc5", "gene_names_refseq": "Ttc5", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 5; Protein Strap; Stress-responsive activator of p300; TPR repeat protein 5", "protein_names_refseq": "TPR repeat protein 5; protein Strap; strap; stress-responsive activator of p300; tetratricopeptide repeat protein 5", "tax_id": 10116, "disease": "", "pathway": " (rno:305837); (R-RNO-6804760)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cofactor involved in the regulation of various cellular mechanisms such as actin regulation, autophagy, chromatin regulation and DNA repair. In physiological conditions, interacts with cofactor JMY in the cytoplasm which prevents JMY's actin nucleation activity and ability to activate the Arp2/3 complex. Acts as a negative regulator of nutrient stress-induced autophagy by inhibiting JMY's interaction with MAP1LC3B, thereby preventing autophagosome formation (By similarity). Involves in tubulin autoregulation by promoting its degradation in response to excess soluble tubulin. To do so, associates with the active ribosome near the ribosome exit tunnel and with nascent tubulin polypeptides early during their translation, triggering tubulin mRNA-targeted degradation (By similarity). Following DNA damage, phosphorylated by DNA damage responsive protein kinases ATM and CHEK2, leading to its nuclear accumulation and stability. Nuclear TTC5/STRAP promotes the assembly of a stress-responsive p53/TP53 coactivator complex, which includes the coactivators JMY and p300, thereby increasing p53/TP53-dependent transcription and apoptosis. Also recruits arginine methyltransferase PRMT5 to p53/TP53 when DNA is damaged, allowing PRMT5 to methylate p53/TP53. In DNA stress conditions, also prevents p53/TP53 degradation by E3 ubiquitin ligase MDM2. Upon heat-shock stress, forms a chromatin-associated complex with heat-shock factor 1 HSF1 and p300/EP300 to stimulate heat-shock-responsive transcription, thereby increasing cell survival. Mitochondrial TTC5/STRAP interacts with ATP synthase subunit beta ATP5F1B which decreased ATP synthase activity and lowers mitochondrial ATP production, thereby regulating cellular respiration and mitochondrial-dependent apoptosis. Mitochondrial TTC5/STRAP also regulates p53/TP53-mediated apoptosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006281 DNA repair;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response;GO:0009267 cellular response to starvation;GO:0061014 positive regulation of mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK48-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EAN7-1", "uniprot_id": [ { "id": "TE2IP_RAT", "url": "https://www.uniprot.org/uniprot/Q5EAN7", "type": "external" } ], "mass": 43418.0, "length": 393, "protein_name": "Telomeric repeat-binding factor 2-interacting protein 1", "gene_name": "Terf2ip", "organism": "Rat", "refseq_name": "telomeric repeat-binding factor 2-interacting protein 1", "refseq_ac": [ { "id": "NP_001013161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013161", "type": "external" } ], "gene_names_uniprotkb": "Terf2ip; Rap1", "gene_names_refseq": "Terf2ip", "protein_names_uniprotkb": "Telomeric repeat-binding factor 2-interacting protein 1; RAP1 homolog; Repressor/activator protein 1 homolog; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1", "protein_names_refseq": "RAP1 homolog; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; repressor/activator protein 1 homolog; telomeric repeat binding factor 2, interacting protein; telomeric repeat-binding factor 2-interacting protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:307861); (R-RNO-110330); (R-RNO-110331); (R-RNO-171319); (R-RNO-174411); (R-RNO-174414); (R-RNO-174417); (R-RNO-174430); (R-RNO-174437); (R-RNO-2559586)", "pathway_count": 10, "publication_count": 3, "publication_id_list": "22673903;27050284;29393594", "class_list": "", "function": "Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Rap1 may induce hepatic ischemia reperfusion injury (IRI) through promoting neutrophils inflammatory response. Rap1 may be the potential therapeutic target of attenuating hepatic IRI., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042162 telomeric DNA binding;GO:0098505 G-rich strand telomeric DNA binding;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0070187 shelterin complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0010833 telomere maintenance via telomere lengthening;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0031848 protection from non-homologous end joining at telomere;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5EAN7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVR8-1", "uniprot_id": [ { "id": "TBCC1_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVR8", "type": "external" } ], "mass": 64693.0, "length": 569, "protein_name": "TBCC domain-containing protein 1", "gene_name": "Tbccd1", "organism": "Rat", "refseq_name": "TBCC domain-containing protein 1", "refseq_ac": [ { "id": "NP_001012016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012016", "type": "external" } ], "gene_names_uniprotkb": "Tbccd1", "gene_names_refseq": "Crygs; Tbccd1", "protein_names_uniprotkb": "TBCC domain-containing protein 1", "protein_names_refseq": "TBCC domain-containing protein 1; crystallin, gamma S", "tax_id": 10116, "disease": "", "pathway": " (rno:303830)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031616 spindle pole centrosome;GO:0000922 spindle pole;GO:0005813 centrosome", "go_biological_process": "GO:0051684 maintenance of Golgi location;GO:0030334 regulation of cell migration;GO:0008360 regulation of cell shape;GO:0051661 maintenance of centrosome location", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVR8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIU2-1", "uniprot_id": [ { "id": "ZN143_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIU2", "type": "external" } ], "mass": 68999.0, "length": 638, "protein_name": "Zinc finger protein 143", "gene_name": "Zfp143; Znf143", "organism": "Rat", "refseq_name": "zinc finger protein 143", "refseq_ac": [ { "id": "NP_001012169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012169", "type": "external" } ], "gene_names_uniprotkb": "Zfp143; Znf143; Staf; Zfp143", "gene_names_refseq": "STAF; Zfp143; Znf143", "protein_names_uniprotkb": "Zinc finger protein 143; Selenocysteine tRNA gene transcription-activating factor; Zfp-143", "protein_names_refseq": "selenocysteine tRNA gene transcription-activating factor; zfp-143; zinc finger protein 143", "tax_id": 10116, "disease": "", "pathway": " (rno:361627)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor that activates expression of genes transcribed by both RNA polymerases II and III, and which is required to safeguard mitochondrial activity. Specifically recognizes and binds the Staf-binding site (SBS), a consensus DNA-binding motif present in thousands of promoters. Activates the gene for selenocysteine tRNA (tRNAsec). Activates expression of small nuclear RNA (snRNA) transcribed by RNA polymerases II and III (By similarity). Also activates expression of mRNAs and acts as a key regulator of cell proliferation and differentiation by specifically activating expression of a subset of nuclear-encoded mitochondrial genes, thereby controlling mitochondrial function. Involved in the maintenance of embryonic stem cells by promoting association of POU5F1/OCT4 to promoters, leading to NANOG expresion (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0048661 positive regulation of smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIU2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q642B6-1", "uniprot_id": [ { "id": "THAP4_RAT", "url": "https://www.uniprot.org/uniprot/Q642B6", "type": "external" } ], "mass": 62407.0, "length": 569, "protein_name": "Peroxynitrite isomerase THAP4", "gene_name": "Thap4", "organism": "Rat", "refseq_name": "peroxynitrite isomerase THAP4", "refseq_ac": [ { "id": "NP_001005564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005564", "type": "external" } ], "gene_names_uniprotkb": "Thap4", "gene_names_refseq": "Nb(III); Thap4", "protein_names_uniprotkb": "Peroxynitrite isomerase THAP4; 5.99.-.-; Ferric nitrobindin; Nb(III); THAP domain-containing protein 4", "protein_names_refseq": "THAP domain-containing protein 4; ferric nitrobindin; peroxynitrite isomerase THAP4", "tax_id": 10116, "disease": "", "pathway": " (rno:363291)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29393594;38658415", "class_list": "", "function": "Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mutation of the Thap4 gene causes dwarfism and testicular anomalies in rats and mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.99.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.99.-.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0020037 heme binding;GO:0070026 nitric oxide binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042126 nitrate metabolic process;GO:0006570 tyrosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q642B6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5HZY0-1", "uniprot_id": [ { "id": "UBXN4_RAT", "url": "https://www.uniprot.org/uniprot/Q5HZY0", "type": "external" } ], "mass": 56394.0, "length": 506, "protein_name": "UBX domain-containing protein 4", "gene_name": "Ubxn4", "organism": "Rat", "refseq_name": "UBX domain-containing protein 4", "refseq_ac": [ { "id": "NP_001012025", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012025", "type": "external" } ], "gene_names_uniprotkb": "Ubxn4; Ubxd2; Ubxdc1", "gene_names_refseq": "Ubxd2; Ubxn4", "protein_names_uniprotkb": "UBX domain-containing protein 4; Erasin; UBX domain-containing protein 2", "protein_names_refseq": "UBX domain containing 2; UBX domain-containing protein 2; UBX domain-containing protein 4; erasin", "tax_id": 10116, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (rno:304766)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0036503 ERAD pathway;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5HZY0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70537-1", "uniprot_id": [ { "id": "TSX_RAT", "url": "https://www.uniprot.org/uniprot/P70537", "type": "external" } ], "mass": 16365.0, "length": 144, "protein_name": "Testis-specific protein TSX", "gene_name": "Chic1; Tsx", "organism": "Rat", "refseq_name": "testis-specific protein TSX", "refseq_ac": [ { "id": "NP_062076", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062076", "type": "external" } ], "gene_names_uniprotkb": "Chic1; Tsx", "gene_names_refseq": "Tsx", "protein_names_uniprotkb": "Testis-specific protein TSX", "protein_names_refseq": "testis-specific protein TSX", "tax_id": 10116, "disease": "", "pathway": " (rno:29391); (rno:363484)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;8922998", "class_list": "", "function": "May have an RNA/DNA binding role., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P70537-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8A8-1", "uniprot_id": [ { "id": "ZFP90_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8A8", "type": "external" } ], "mass": 72438.0, "length": 633, "protein_name": "Zinc finger protein 90", "gene_name": "Zfp90", "organism": "Rat", "refseq_name": "zinc finger protein 90", "refseq_ac": [ { "id": "NP_001020936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020936", "type": "external" } ], "gene_names_uniprotkb": "Zfp90", "gene_names_refseq": "Zfp90", "protein_names_uniprotkb": "Zinc finger protein 90; Zfp-90", "protein_names_refseq": "zfp-90; zinc finger protein 90 homolog; zinc finger protein 90", "tax_id": 10116, "disease": "", "pathway": " (rno:498945); (R-RNO-212436)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8A8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97830-1", "uniprot_id": [ { "id": "UNC4_RAT", "url": "https://www.uniprot.org/uniprot/P97830", "type": "external" } ], "mass": 53880.0, "length": 530, "protein_name": "Homeobox protein unc-4 homolog", "gene_name": "Uncx", "organism": "Rat", "refseq_name": "homeobox protein unc-4 homolog", "refseq_ac": [ { "id": "NP_058875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058875", "type": "external" } ], "gene_names_uniprotkb": "Uncx; Phd1; Uncx4.1", "gene_names_refseq": "Chx4; PHD1; Uncx4.1; Uncx", "protein_names_uniprotkb": "Homeobox protein unc-4 homolog; Homeobox protein Uncx4.1; Paired-type homeodomain transcription factor 1", "protein_names_refseq": "Unc4.1 homeobox; homeobox protein Uncx4.1; homeobox protein unc-4 homolog; paired-type homeodomain transcription factor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:29375)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8948581", "class_list": "", "function": "Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021516 dorsal spinal cord development;GO:0006351 DNA-templated transcription;GO:0045595 regulation of cell differentiation;GO:0010468 regulation of gene expression;GO:0001502 cartilage condensation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P97830-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5CD77-1", "uniprot_id": [ { "id": "TBC14_RAT", "url": "https://www.uniprot.org/uniprot/Q5CD77", "type": "external" } ], "mass": 78209.0, "length": 694, "protein_name": "TBC1 domain family member 14", "gene_name": "Tbc1d14", "organism": "Rat", "refseq_name": "TBC1 domain family member 14 isoform 1", "refseq_ac": [ { "id": "NP_001012152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012152", "type": "external" } ], "gene_names_uniprotkb": "Tbc1d14; UR-NR#2", "gene_names_refseq": "SRF-2; Tbc1d14; UR-NR#2", "protein_names_uniprotkb": "TBC1 domain family member 14; SRF-2; Spermatogenesis-related factor 2; Up-regulated in nephrectomized rat kidney #2", "protein_names_refseq": "TBC1 domain family member 14 isoform 1; Up-regulated in nephrectomized rat kidney #2; spermatogenesis-related factor 2", "tax_id": 10116, "disease": "", "pathway": " (rno:360956); (R-RNO-8854214)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15200410;15758561", "class_list": "", "function": "Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q499U3;Q6I7R4", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0019901 protein kinase binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0055037 recycling endosome;GO:0005776 autophagosome;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0010507 negative regulation of autophagy;GO:2000785 regulation of autophagosome assembly;GO:0071955 recycling endosome to Golgi transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5CD77-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLI1-1", "uniprot_id": [ { "id": "ZKSC1_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLI1", "type": "external" } ], "mass": 63365.0, "length": 562, "protein_name": "Zinc finger protein with KRAB and SCAN domains 1", "gene_name": "Zkscan1", "organism": "Rat", "refseq_name": "zinc finger protein with KRAB and SCAN domains 1", "refseq_ac": [ { "id": "NP_001020931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020931", "type": "external" } ], "gene_names_uniprotkb": "Zkscan1", "gene_names_refseq": "Zkscan1", "protein_names_uniprotkb": "Zinc finger protein with KRAB and SCAN domains 1", "protein_names_refseq": "zinc finger protein 36 (KOX 18); zinc finger protein with KRAB and SCAN domains 1", "tax_id": 10116, "disease": "", "pathway": " (rno:498160); (R-RNO-212436)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4KLI1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62941-1", "uniprot_id": [ { "id": "ZNT2_RAT", "url": "https://www.uniprot.org/uniprot/Q62941", "type": "external" } ], "mass": 39277.0, "length": 359, "protein_name": "Proton-coupled zinc antiporter SLC30A2", "gene_name": "Slc30a2", "organism": "Rat", "refseq_name": "proton-coupled zinc antiporter SLC30A2 isoform 2", "refseq_ac": [ { "id": "NP_037022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037022", "type": "external" } ], "gene_names_uniprotkb": "Slc30a2; Znt2", "gene_names_refseq": "Slc30a2; ZnT-2; Znt2", "protein_names_uniprotkb": "Proton-coupled zinc antiporter SLC30A2; Solute carrier family 30 member 2; Zinc transporter 2; ZnT-2", "protein_names_refseq": "proton-coupled zinc antiporter SLC30A2 isoform 2; proton-coupled zinc antiporter SLC30A2; solute carrier family 30 (zinc transporter), member 2; zinc transporter 2", "tax_id": 10116, "disease": "", "pathway": " (rno:25362)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12399528;15475177;18289514;19760107;20133611;20798384;8617223", "class_list": "", "function": "Electroneutral proton-coupled antiporter concentrating zinc ions into a variety of intracellular organelles including endosomes, zymogen granules and mitochondria. Thereby, plays a crucial role in cellular zinc homeostasis to confer upon cells protection against its potential cytotoxicity (PubMed:20133611, PubMed:8617223). Regulates the zinc concentration of milk, through the transport of zinc ions into secretory vesicles of mammary cells (By similarity). By concentrating zinc ions into lysosomes participates to lysosomal-mediated cell death during early mammary gland involution (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Expression of the zinc transporter in ventral prostate (VP) of aged rats (21 months) was approximately 21-fold higher than that in VP of young rats (4 months), and zinc levels in VP of young rats increased significantly compared with that in aged rats., [RefSeq, PubMed]; Expression of zinc transporter-2 in lateral and dorsal prostate was unaffected by castration. Factors regulating zinc homeostasis other than zinc transporters are involved in lowering zinc content after castration in rat prostate., [RefSeq, PubMed]; The protein encoded by this gene is a zinc transporter. It is localized in the vesicles and suggested to protect the cells from zinc toxicity by facilitating vesicular sequestration. Alternatively spliced transcript variants have been found for this gene, one of which initiates translation from a non-AUG (CUG) start codon. [provided by RefSeq, Jul 2008]., [RefSeq]; The results indicate that ZnT2 may play a significant role in the maintenance of zinc homeostasis in the prostate., [RefSeq, PubMed]; The upregulation of ZnT1, ZnT2, and ZnT4 was to decrease the cytosolic zinc levels caused by NO after transient occlusion of the CCA., [RefSeq, PubMed]; There were no differences between the mRNA expression levels of ZnT family members in undifferentiated Rcho-1 cells and differentiated Rcho-1 cells., [RefSeq, PubMed]; Transfection and mutation studies show that translation initiates at a non-AUG (CUG) start codon., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0140826 zinc:proton antiporter activity;GO:0008324 monoatomic cation transmembrane transporter activity", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0010043 response to zinc ion;GO:0006882 intracellular zinc ion homeostasis;GO:0140882 zinc export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62941-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQJ7-1", "uniprot_id": [ { "id": "TBCEL_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQJ7", "type": "external" } ], "mass": 48046.0, "length": 424, "protein_name": "Tubulin-specific chaperone cofactor E-like protein", "gene_name": "Tbcel", "organism": "Rat", "refseq_name": "tubulin-specific chaperone cofactor E-like protein", "refseq_ac": [ { "id": "NP_001014111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014111", "type": "external" } ], "gene_names_uniprotkb": "Tbcel; Lrrc35", "gene_names_refseq": "Lrrc35; RGD1308880; Tbcel", "protein_names_uniprotkb": "Tubulin-specific chaperone cofactor E-like protein; Leucine-rich repeat-containing protein 35", "protein_names_refseq": "leucine rich repeat containing 35; leucine-rich repeat-containing protein 35; tubulin-specific chaperone cofactor E-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:315591)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Acts as a regulator of tubulin stability., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization;GO:0007021 tubulin complex assembly;GO:0007023 post-chaperonin tubulin folding pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PQJ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q499V6-1", "uniprot_id": [ { "id": "ZCRB1_RAT", "url": "https://www.uniprot.org/uniprot/Q499V6", "type": "external" } ], "mass": 24545.0, "length": 217, "protein_name": "Zinc finger CCHC-type and RNA-binding motif-containing protein 1", "gene_name": "Zcrb1", "organism": "Rat", "refseq_name": "zinc finger CCHC-type and RNA-binding motif-containing protein 1", "refseq_ac": [ { "id": "NP_001030112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030112", "type": "external" } ], "gene_names_uniprotkb": "Zcrb1", "gene_names_refseq": "RGD1309851; Zcrb1", "protein_names_uniprotkb": "Zinc finger CCHC-type and RNA-binding motif-containing protein 1; U11/U12 small nuclear ribonucleoprotein 31 kDa protein; U11/U12 snRNP 31 kDa protein", "protein_names_refseq": "U11/U12 small nuclear ribonucleoprotein 31 kDa protein; U11/U12 snRNP 31 kDa protein; zinc finger CCHC-type and RNA binding motif 1; zinc finger CCHC-type and RNA-binding motif-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:362990); (R-RNO-72165)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0034693 U11/U12 snRNP;GO:0005689 U12-type spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q499V6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63678-1", "uniprot_id": [ { "id": "ZA2G_RAT", "url": "https://www.uniprot.org/uniprot/Q63678", "type": "external" } ], "mass": 34017.0, "length": 296, "protein_name": "Zinc-alpha-2-glycoprotein", "gene_name": "Azgp1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Azgp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc-alpha-2-glycoprotein; Zn-alpha-2-GP; Zn-alpha-2-glycoprotein", "protein_names_refseq": "", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); otospondylomegaepiphyseal dysplasia, autosomal recessive (Disease Ontology:DOID:0080026); Stickler syndrome (Disease Ontology:DOID:0080046); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); fibrochondrogenesis 2 (Disease Ontology:DOID:0080673); otospondylomegaepiphyseal dysplasia, autosomal dominant (Disease Ontology:DOID:0080677); autosomal recessive nonsyndromic deafness 53 (Disease Ontology:DOID:0110509); autosomal dominant nonsyndromic deafness 13 (Disease Ontology:DOID:0110545); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); epilepsy (Disease Ontology:DOID:1826); colon cancer (Disease Ontology:DOID:219); osteochondrodysplasia (Disease Ontology:DOID:2256); acute kidney failure (Disease Ontology:DOID:3021); temporal lobe epilepsy (Disease Ontology:DOID:3328); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung adenocarcinoma (Disease Ontology:DOID:3910); liver cirrhosis (Disease Ontology:DOID:5082); stomach carcinoma (Disease Ontology:DOID:5517); cleft palate (Disease Ontology:DOID:674); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); chronic kidney disease (Disease Ontology:DOID:784); colorectal cancer (Disease Ontology:DOID:9256); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25294); (R-RNO-5223345)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "7852290;8056339", "class_list": "", "function": "Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q63523", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0006955 immune response;GO:0007155 cell adhesion;GO:0032869 cellular response to insulin stimulus;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63678-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HC1-1", "uniprot_id": [ { "id": "TDRD3_RAT", "url": "https://www.uniprot.org/uniprot/Q66HC1", "type": "external" } ], "mass": 73028.0, "length": 651, "protein_name": "Tudor domain-containing protein 3", "gene_name": "Tdrd3", "organism": "Rat", "refseq_name": "tudor domain-containing protein 3 isoform 3", "refseq_ac": [ { "id": "NP_001012043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012043", "type": "external" } ], "gene_names_uniprotkb": "Tdrd3", "gene_names_refseq": "Tdrd3", "protein_names_uniprotkb": "Tudor domain-containing protein 3", "protein_names_refseq": "tudor domain-containing protein 3 isoform 3; tudor domain-containing protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:306066)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0140008 histone H4 reader activity;GO:0140006 histone H3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0035145 exon-exon junction complex;GO:0140225 DNA topoisomerase III-beta-TDRD3 complex", "go_biological_process": "GO:0141194 siRNA-mediated heterochromatin formation;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66HC1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVR1-1", "uniprot_id": [ { "id": "ZDHC4_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVR1", "type": "external" } ], "mass": 39397.0, "length": 343, "protein_name": "Palmitoyltransferase ZDHHC4", "gene_name": "Zdhhc4", "organism": "Rat", "refseq_name": "palmitoyltransferase ZDHHC4", "refseq_ac": [ { "id": "NP_001013141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013141", "type": "external" } ], "gene_names_uniprotkb": "Zdhhc4", "gene_names_refseq": "Zdhhc4", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC4; 2.3.1.225; DHHC-4; Zinc finger DHHC domain-containing protein 4", "protein_names_refseq": "DHHC-4; membrane-associated DHHC4 zinc finger protein; palmitoyltransferase ZDHHC4; probable palmitoyltransferase ZDHHC4; zinc finger DHHC domain-containing protein 4; zinc finger DHHC-type palmitoyltransferase 4; zinc finger, DHHC domain containing 4; zinc finger, DHHC-type containing 4", "tax_id": 10116, "disease": "", "pathway": " (rno:304291)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Palmitoyltransferase that could catalyze the addition of palmitate onto protein substrates including the D(2) dopamine receptor DRD2, GSK3B or MAVS. Mediates GSK3B palmitoylation to prevent its AKT1-mediated phosphorylation leading to activation of the STAT3 signaling pathway. Also catalyzes MAVS palmitoylation which promotes its stabilization and activation by inhibiting 'Lys-48'- but facilitating 'Lys-63'-linked ubiquitination., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2TGK2", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006612 protein targeting to membrane;GO:0045089 positive regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVR1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4VSI4-1", "uniprot_id": [ { "id": "UBP7_RAT", "url": "https://www.uniprot.org/uniprot/Q4VSI4", "type": "external" } ], "mass": 128431.0, "length": 1103, "protein_name": "Ubiquitin C-terminal hydrolase 7", "gene_name": "Usp7", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 7", "refseq_ac": [ { "id": "NP_001019961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019961", "type": "external" } ], "gene_names_uniprotkb": "Usp7; Hausp", "gene_names_refseq": "Hausp; Usp7", "protein_names_uniprotkb": "Ubiquitin C-terminal hydrolase 7; 3.4.19.12; Deubiquitinating enzyme 7; Herpesvirus-associated ubiquitin-specific protease; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7; rHAUSP", "protein_names_refseq": "deubiquitinating enzyme 7; herpes-virus-associated ubiquitin-specific protease; herpesvirus-associated ubiquitin-specific protease; rHAUSP; ubiquitin carboxyl-terminal hydrolase 7; ubiquitin specific peptidase 7 (herpes virus-associated); ubiquitin specific protease 7 (herpes virus-associated); ubiquitin thioesterase 7; ubiquitin-specific-processing protease 7", "tax_id": 10116, "disease": "", "pathway": " (rno:360471); (R-RNO-5689880); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6804757); (R-RNO-8866652); (R-RNO-8948747)", "pathway_count": 8, "publication_count": 9, "publication_id_list": "16111684;16328052;22673903;29393594;33157209;33170804;33241864;35538032;37257587", "class_list": "", "function": "A rat HAUSP from testis was identified and cloned., [RefSeq, PubMed]; Data show that rat HAUSP (rHAUSP, Usp7_predicted) is polyubiquitinated, polyneddylated, and dimerized, and suggest that rHAUSP may function as a dimer or multimer and is also degraded through the proteasome-mediated degradation., [RefSeq, PubMed]; Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy., [RefSeq, PubMed]; Hydrolase that deubiquitinates target proteins such as ARMC5, FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:16111684, PubMed:16328052). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (By similarity). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (By similarity). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (By similarity). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML (By similarity). Deubiquitinates KMT2E preventing KMT2E proteasomal-mediated degradation (By similarity). Involved in cell proliferation during early embryonic development (By similarity). Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (By similarity). Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1 (By similarity). Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (By similarity). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (By similarity). Able to mediate deubiquitination of histone H2B; it is however unsure whether this activity takes place in vivo (By similarity). Exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing transcription factor FOXP3 which is crucial for Treg cell function (By similarity). Plays a role in the maintenance of the circadian clock periodicity via deubiquitination and stabilization of the CRY1 and CRY2 proteins (By similarity). Deubiquitinates REST, thereby stabilizing REST and promoting the maintenance of neural progenitor cells (By similarity). Deubiquitinates SIRT7, inhibiting SIRT7 histone deacetylase activity and regulating gluconeogenesis (By similarity). Involved in the regulation of WASH-dependent actin polymerization at the surface of endosomes and the regulation of endosomal protein recycling (By similarity). It maintains optimal WASH complex activity and precise F-actin levels via deubiquitination of TRIM27 and WASHC1 (By similarity). Mediates the deubiquitination of phosphorylated DEPTOR, promoting its stability and leading to decreased mTORC1 signaling (By similarity). Deubiquitinates H2AB1, H2BC4 and H2BC22 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Inhibition of USP7 suppresses advanced glycation end-induced cell cycle arrest and senescence of human umbilical vein endothelial cells through ubiquitination of p53., [RefSeq, PubMed]; USP7 regulates HMOX-1 via deubiquitination to suppress ferroptosis and ameliorate spinal cord injury in rats., [RefSeq, PubMed]; USP7, negatively regulated by miR-409-5p, aggravates hypoxia-induced cardiomyocyte injury., [RefSeq, PubMed]; Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0002039 p53 binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0043065 positive regulation of apoptotic process;GO:0006307 DNA alkylation repair;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q4VSI4-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPG4-1", "uniprot_id": [ { "id": "ZN639_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPG4", "type": "external" } ], "mass": 55532.0, "length": 485, "protein_name": "Zinc finger protein 639", "gene_name": "Zfp639; Znf639", "organism": "Rat", "refseq_name": "zinc finger protein 639", "refseq_ac": [ { "id": "NP_001074376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074376", "type": "external" } ], "gene_names_uniprotkb": "Zfp639; Znf639", "gene_names_refseq": "Zfp639; Znf639", "protein_names_uniprotkb": "Zinc finger protein 639", "protein_names_refseq": "zinc finger protein 639", "tax_id": 10116, "disease": "", "pathway": " (rno:683504)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Binds DNA and may function as a transcriptional repressor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030307 positive regulation of cell growth;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PPG4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68VK5-1", "uniprot_id": [ { "id": "TSN5_RAT", "url": "https://www.uniprot.org/uniprot/Q68VK5", "type": "external" } ], "mass": 30337.0, "length": 268, "protein_name": "Tetraspanin-5", "gene_name": "Tspan5", "organism": "Rat", "refseq_name": "tetraspanin-5", "refseq_ac": [ { "id": "NP_001004090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004090", "type": "external" } ], "gene_names_uniprotkb": "Tspan5; Tm4sf9", "gene_names_refseq": "Tm4sf9; Tspan-5; Tspan5", "protein_names_uniprotkb": "Tetraspanin-5; Transmembrane 4 superfamily member 9; Tspan-5", "protein_names_refseq": "tetraspan 5; tetraspanin-5; transmembrane 4 superfamily member 9", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:362048)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "36795458", "class_list": "", "function": "Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Promotes ADAM10-mediated cleavage of CD44. Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration., [UniProtKB, UniProtKB]; The tetraspanin TSPAN5 regulates AMPAR exocytosis by interacting with the AP4 complex. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q498N9", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0072659 protein localization to plasma membrane;GO:0045747 positive regulation of Notch signaling pathway;GO:0051604 protein maturation;GO:0051043 regulation of membrane protein ectodomain proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68VK5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M7W1-1", "uniprot_id": [ { "id": "TXNIP_RAT", "url": "https://www.uniprot.org/uniprot/Q5M7W1", "type": "external" } ], "mass": 44018.0, "length": 394, "protein_name": "Thioredoxin-interacting protein", "gene_name": "Txnip", "organism": "Rat", "refseq_name": "thioredoxin-interacting protein", "refseq_ac": [ { "id": "NP_001008767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008767", "type": "external" } ], "gene_names_uniprotkb": "Txnip; Vdup1", "gene_names_refseq": "Txnip; Vdup1", "protein_names_uniprotkb": "Thioredoxin-interacting protein; Vitamin D3 up-regulated protein 1", "protein_names_refseq": "thioredoxin-interacting protein; upregulated by 1,25-dihydroxyvitamin D-3; vitamin D3 up-regulated protein 1", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534); Reye syndrome (Disease Ontology:DOID:14525); glaucoma (Disease Ontology:DOID:1686); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:117514); (R-RNO-844456)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12011048;29393594;31164864;31708773;35562171;36642539;37749991;37814350;38614227", "class_list": "", "function": "Energy restriction induced SIRT6 inhibits microglia activation and promotes angiogenesis in cerebral ischemia via transcriptional inhibition of TXNIP. Publication Status: Online-Only, [RefSeq, PubMed]; May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (By similarity). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (By similarity). Required for the maturation of natural killer cells (By similarity). Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SRY-box transcription factor 9 modulates Muller cell gliosis in diabetic retinopathy by upregulating TXNIP transcription., [RefSeq, PubMed]; TXNIP activates NLRP3/IL-1beta and participate in inflammatory response and oxidative stress to promote deep venous thrombosis., [RefSeq, PubMed]; TXNIP knockdown protects rats against bupivacaine-induced spinal neurotoxicity via the inhibition of oxidative stress and apoptosis., [RefSeq, PubMed]; Ubiquitin-specific peptidase 25 exacerbated osteoarthritis progression through facilitating TXNIP ubiquitination and NLRP3 inflammasome activation. Publication Status: Online-Only, [RefSeq, PubMed]; Vitamin D(3)-up-regulated protein-1/thioredoxin axis has an important role in the preservation of cellular viability, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004857 enzyme inhibitor activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0071228 cellular response to tumor cell;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006979 response to oxidative stress;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q5M7W1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M7W7-1", "uniprot_id": [ { "id": "SYPM_RAT", "url": "https://www.uniprot.org/uniprot/Q5M7W7", "type": "external" } ], "mass": 53333.0, "length": 475, "protein_name": "Probable proline--tRNA ligase, mitochondrial", "gene_name": "Pars2", "organism": "Rat", "refseq_name": "probable proline--tRNA ligase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001014086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014086", "type": "external" } ], "gene_names_uniprotkb": "Pars2", "gene_names_refseq": "Pars2; RGD1305345", "protein_names_uniprotkb": "Probable proline--tRNA ligase, mitochondrial; 6.1.1.15; ProRS; Prolyl-tRNA synthetase", "protein_names_refseq": "proRS; probable proline--tRNA ligase, mitochondrial precursor; probable proline--tRNA ligase, mitochondrial; probable prolyl-tRNA synthetase, mitochondrial; proline--tRNA ligase; prolyl-tRNA synthetase (mitochondrial)(putative); prolyl-tRNA synthetase 2, mitochondrial (putative)", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 75 (Disease Ontology:DOID:0112211)", "pathway": " (rno:313429)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial aminoacyl-tRNA synthetase that catalyzes the specific attachment of the proline amino acid (aa) to the homologous transfer RNA (tRNA), further participating in protein synthesis. The reaction occurs in a two steps: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.15", "type": "external" }, { "id": "6.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.17", "type": "external" } ], "go_molecular_function": "GO:0004827 proline-tRNA ligase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005737 cytoplasm", "go_biological_process": "GO:0006433 prolyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M7W7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FWT9-1", "uniprot_id": [ { "id": "SIKE1_RAT", "url": "https://www.uniprot.org/uniprot/Q5FWT9", "type": "external" } ], "mass": 23578.0, "length": 207, "protein_name": "Suppressor of IKBKE 1", "gene_name": "Sike1", "organism": "Rat", "refseq_name": "suppressor of IKBKE 1", "refseq_ac": [ { "id": "NP_001012182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012182", "type": "external" } ], "gene_names_uniprotkb": "Sike1; Sike", "gene_names_refseq": "RGD1311316; Sike1; Sike", "protein_names_uniprotkb": "Suppressor of IKBKE 1; Suppressor of IKK-epsilon", "protein_names_refseq": "suppressor of IKBKE 1; suppressor of IKK-epsilon", "tax_id": 10116, "disease": "", "pathway": " (rno:362007)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-kappa-B activation pathways. Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex. The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0090443 FAR/SIN/STRIPAK complex", "go_biological_process": "GO:0035331 negative regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FWT9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2M7-1", "uniprot_id": [ { "id": "ZFAN3_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2M7", "type": "external" } ], "mass": 25082.0, "length": 227, "protein_name": "AN1-type zinc finger protein 3", "gene_name": "Zfand3", "organism": "Rat", "refseq_name": "AN1-type zinc finger protein 3", "refseq_ac": [ { "id": "NP_001012175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012175", "type": "external" } ], "gene_names_uniprotkb": "Zfand3; Tex27", "gene_names_refseq": "Tex27; Zfand3", "protein_names_uniprotkb": "AN1-type zinc finger protein 3; Testis-expressed protein 27", "protein_names_refseq": "AN1-type zinc finger protein 3; testis expressed gene 27; testis-expressed protein 27; testis-expressed sequence 27; zinc finger, AN1-type domain 3", "tax_id": 10116, "disease": "", "pathway": " (rno:361816)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2M7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2WEA5-1", "uniprot_id": [ { "id": "TRPM1_RAT", "url": "https://www.uniprot.org/uniprot/Q2WEA5", "type": "external" } ], "mass": 184523.0, "length": 1630, "protein_name": "Transient receptor potential cation channel subfamily M member 1", "gene_name": "Trpm1", "organism": "Rat", "refseq_name": "transient receptor potential cation channel subfamily M member 1 isoform 2", "refseq_ac": [ { "id": "NP_001032822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032822", "type": "external" } ], "gene_names_uniprotkb": "Trpm1", "gene_names_refseq": "Trpm1", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily M member 1; Melastatin-1", "protein_names_refseq": "melastatin-1; melastatin; transient receptor potential cation channel subfamily M member 1 isoform 2", "tax_id": 10116, "disease": "congenital stationary night blindness (Disease Ontology:DOID:0050534); chromosome 15q13.3 microdeletion syndrome (Disease Ontology:DOID:0060394); congenital stationary night blindness 1C (Disease Ontology:DOID:0110867)", "pathway": " (rno:361586); (R-RNO-3295583)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15856355;17712480;27435061", "class_list": "", "function": "A molecular mechanism for the potential regulation of TRPM1 by S100A1, [RefSeq, PubMed]; Constitutively open nonselective divalent cation-conducting channels which mediate the influx of Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization. Impermeable to zinc ions. In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions. Plays an essential role for the depolarizing photoresponse of retinal ON bipolar cells (By similarity). In the dark, tonic release of glutamate activates the G protein-coupled receptor for glutamate GRM6, its activation induces the release of G(o) protein and the beta-gamma G protein dimer. Both subunits can interact and inactivate the TRPM1 channel. A light onset, induces decrease in glutamate release and deactivation of GRM6 leading to channel opening and membrane depolarization (By similarity). May play a role in metastasis suppression (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Polymerase chain reaction used to check the expression of all TRPM and TRPV channel members with specific primers., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F1M9X0;Q2WEA4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0005262 calcium channel activity;GO:0008324 monoatomic cation transmembrane transporter activity;GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0035841 new growing cell tip;GO:0051286 cell tip;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0007165 signal transduction;GO:0051262 protein tetramerization;GO:0006816 calcium ion transport;GO:0007601 visual perception;GO:0098655 monoatomic cation transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2WEA5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXQ9-1", "uniprot_id": [ { "id": "IFT46_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXQ9", "type": "external" } ], "mass": 34032.0, "length": 301, "protein_name": "Intraflagellar transport protein 46 homolog", "gene_name": "Ift46", "organism": "Rat", "refseq_name": "intraflagellar transport protein 46 homolog", "refseq_ac": [ { "id": "NP_001019931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019931", "type": "external" } ], "gene_names_uniprotkb": "Ift46", "gene_names_refseq": "Ift46; RGD1307682", "protein_names_uniprotkb": "Intraflagellar transport protein 46 homolog", "protein_names_refseq": "intraflagellar transport 46 homolog; intraflagellar transport protein 46 homolog; intraflagellar transport protein IFT46", "tax_id": 10116, "disease": "", "pathway": " (rno:300675); (R-RNO-5620924)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17720815;22673903", "class_list": "", "function": "Characterization of a similar gene in mouse and zebrafish., [RefSeq, PubMed]; Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V7E9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005929 cilium;GO:0031514 motile cilium;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway;GO:0042073 intraciliary transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AXQ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98166-1", "uniprot_id": [ { "id": "VLDLR_RAT", "url": "https://www.uniprot.org/uniprot/P98166", "type": "external" } ], "mass": 96542.0, "length": 873, "protein_name": "Very low-density lipoprotein receptor", "gene_name": "Vldlr", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Vldlr", "gene_names_refseq": "", "protein_names_uniprotkb": "Very low-density lipoprotein receptor; VLDL receptor; VLDL-R", "protein_names_refseq": "", "tax_id": 10116, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1 (Disease Ontology:DOID:0070556); age related macular degeneration 1 (Disease Ontology:DOID:0110014); Alzheimer's disease (Disease Ontology:DOID:10652); nephrotic syndrome (Disease Ontology:DOID:1184); morbid obesity (Disease Ontology:DOID:11981); autistic disorder (Disease Ontology:DOID:12849); dementia (Disease Ontology:DOID:1307); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312)", "pathway": " (rno:25696); (R-RNO-8866376); (R-RNO-8866427); (R-RNO-8964046)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "7929362", "class_list": "", "function": "Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Also binds to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU. In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8. Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (By similarity). This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034185 apolipoprotein binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0001618 virus receptor activity;GO:0030296 protein tyrosine kinase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0009986 cell surface", "go_biological_process": "GO:0006869 lipid transport;GO:0007166 cell surface receptor signaling pathway;GO:0007507 heart development;GO:0007584 response to nutrient;GO:0008203 cholesterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P98166-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62815-1", "uniprot_id": [ { "id": "VATB2_RAT", "url": "https://www.uniprot.org/uniprot/P62815", "type": "external" } ], "mass": 56551.0, "length": 511, "protein_name": "V-type proton ATPase subunit B, brain isoform", "gene_name": "Atp6v1b2", "organism": "Rat", "refseq_name": "V-type proton ATPase subunit B, brain isoform", "refseq_ac": [ { "id": "NP_476561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476561", "type": "external" } ], "gene_names_uniprotkb": "Atp6v1b2; Atp6b2; Vat2", "gene_names_refseq": "Atp6b1b2; Atp6b2; Atp6v1b2; Vatb", "protein_names_uniprotkb": "V-type proton ATPase subunit B, brain isoform; Endomembrane proton pump 58 kDa subunit; V-ATPase subunit B 2; Vacuolar proton pump subunit B 2", "protein_names_refseq": "ATPase, H transporting, lysosomal V1 subunit B2; ATPase, H+ transporting, V1 subunit B; ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa; V-ATPase subunit B 2; V-type proton ATPase subunit B, brain isoform; endomembrane proton pump 58 kDa subunit; vacuolar H+ATPase B2; vacuolar proton pump subunit B 2", "tax_id": 10116, "disease": "follicular lymphoma (Disease Ontology:DOID:0050873); autosomal dominant congenital deafness with onychodystrophy (Disease Ontology:DOID:0080720); renal tubular acidosis (Disease Ontology:DOID:14219); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:117596); (R-RNO-1222556); (R-RNO-77387); (R-RNO-917977); (R-RNO-9639288); (R-RNO-983712)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "15013950;18683930;19396617;20169059;32165585", "class_list": "", "function": "Data show that silencing of V-ATPase a1 and B2 subunits decreased stimulated surfactant secretion. Publication Status: Online-Only, [RefSeq, PubMed]; Expressed in most, if not all, proton-secreting cells in the epithelium lining the nephron and the collecting ducts, and it is also present in proton-secreting clear cells of the epididymis, [RefSeq, PubMed]; Long-term exposure of proximal tubule cells to angiotensin II causes upregulation of H(+)-ATPase activity due to increased B2-subunit cell-surface expression, which is dependent on mechanisms involving tyrosine kinase, p38 MAPK, and PI3K activation., [RefSeq, PubMed]; Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09045;P50517", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0046034 ATP metabolic process;GO:0030641 regulation of cellular pH;GO:0097401 synaptic vesicle lumen acidification;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P62815-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02975-1", "uniprot_id": [ { "id": "Z354A_RAT", "url": "https://www.uniprot.org/uniprot/Q02975", "type": "external" } ], "mass": 66253.0, "length": 576, "protein_name": "Zinc finger protein 354A", "gene_name": "Zfp354a; Znf354a", "organism": "Rat", "refseq_name": "zinc finger protein 354A isoform a", "refseq_ac": [ { "id": "NP_434685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_434685", "type": "external" } ], "gene_names_uniprotkb": "Zfp354a; Znf354a; Kid1; Tcf17; Zfp354a", "gene_names_refseq": "Kid1; Tcf17; Zfp354a; Znf354a", "protein_names_uniprotkb": "Zinc finger protein 354A; Kidney, ischemia, and developmentally-regulated protein 1; Renal transcription factor Kid-1; TCF-17; Transcription factor 17", "protein_names_refseq": "Kidney 1; TCF-17; kidney, ischemia, and developmentally-regulated protein 1; renal transcription factor Kid-1; transcription factor 17; zinc finger protein 354A isoform a", "tax_id": 10116, "disease": "seminoma (Disease Ontology:DOID:4440); in situ carcinoma (Disease Ontology:DOID:8719)", "pathway": " (rno:24522); (R-RNO-212436); (R-RNO-9843940)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "19519174;8020966;8382778", "class_list": "", "function": "Clock-controlled Kid-1 regulates the cell cycle of proliferating renal tubular epithelial cells through ERK phosphorylation., [RefSeq, PubMed]; It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0007000 nucleolus organization;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q02975-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4JM44-1", "uniprot_id": [ { "id": "SMS2_RAT", "url": "https://www.uniprot.org/uniprot/Q4JM44", "type": "external" } ], "mass": 42223.0, "length": 365, "protein_name": "Phosphatidylcholine:ceramide cholinephosphotransferase 2", "gene_name": "Sgms2", "organism": "Rat", "refseq_name": "phosphatidylcholine:ceramide cholinephosphotransferase 2", "refseq_ac": [ { "id": "NP_001014065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014065", "type": "external" } ], "gene_names_uniprotkb": "Sgms2", "gene_names_refseq": "RGD1305778; Sgms2; Sms2; spermatin", "protein_names_uniprotkb": "Phosphatidylcholine:ceramide cholinephosphotransferase 2; 2.7.8.27; Sms2; Sphingomyelin synthase 2", "protein_names_refseq": "phosphatidylcholine:ceramide cholinephosphotransferase 2", "tax_id": 10116, "disease": "calvarial doughnut lesions with bone fragility (Disease Ontology:DOID:0080721)", "pathway": " (rno:310849); (R-RNO-1660661)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17210739;21980337;29294205", "class_list": "", "function": "In contrast to Sgms1, Sgms2 does not contain the multi-exon 5'-UTR but encodes circRNAs, which are composed of the coding region of the gene and are expressed at a low level., [RefSeq, PubMed]; SMS1 and SMS2 are capable of regulating TGN-mediated protein trafficking and secretion, [RefSeq, PubMed]; Sphingomyelin synthase that primarily contributes to sphingomyelin synthesis and homeostasis at the plasma membrane. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction appears to depend on the levels of CER and DAG in the plasma membrane (By similarity). Does not use free phosphorylcholine or CDP-choline as donors (By similarity). Can also transfer phosphoethanolamine head group of phosphatidylethanolamine (PE) on to ceramide (CER) to form ceramide phosphoethanolamine (CPE) (By similarity). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting (By similarity). To a lesser extent, plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1 (PubMed:21980337). Required for normal bone matrix mineralization (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U2Z1", "ec_number_list": [ { "id": "3.1.4.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.62", "type": "external" }, { "id": "2.7.8.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.27", "type": "external" } ], "go_molecular_function": "GO:0002950 ceramide phosphoethanolamine synthase activity;GO:0033188 sphingomyelin synthase activity;GO:0047493 ceramide cholinephosphotransferase activity;GO:0016301 kinase activity;GO:0016780 phosphotransferase activity, for other substituted phosphate groups", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:1905373 ceramide phosphoethanolamine biosynthetic process;GO:0046513 ceramide biosynthetic process;GO:0030500 regulation of bone mineralization;GO:0006665 sphingolipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4JM44-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EGY4-1", "uniprot_id": [ { "id": "YKT6_RAT", "url": "https://www.uniprot.org/uniprot/Q5EGY4", "type": "external" } ], "mass": 22369.0, "length": 198, "protein_name": "Synaptobrevin homolog YKT6", "gene_name": "Ykt6", "organism": "Rat", "refseq_name": "synaptobrevin homolog YKT6", "refseq_ac": [ { "id": "NP_113880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113880", "type": "external" } ], "gene_names_uniprotkb": "Ykt6", "gene_names_refseq": "Ykt6", "protein_names_uniprotkb": "Synaptobrevin homolog YKT6; 2.3.1.-", "protein_names_refseq": "YKT6 homolog; YKT6 v-SNARE homolog; prenylated SNARE protein; synaptobrevin homolog YKT6", "tax_id": 10116, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (rno:64351); (R-RNO-204005); (R-RNO-6807878); (R-RNO-6811438); (R-RNO-8980692); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9013408); (R-RNO-9013423)", "pathway_count": 9, "publication_count": 11, "publication_id_list": "10073573;11323436;11927603;12388752;12589064;15331663;22443861;27493064;28770820;30119892;37380075", "class_list": "", "function": "Data suggest that GS15 exists in a distinct SNARE complex that contains syntaxin5, GS28, and Ykt6, and may be involved in both ER-to-Golgi and intra-Golgi transport., [RefSeq, PubMed]; Different conformational dynamics of SNARE protein Ykt6 among yeast and mammals., [RefSeq, PubMed]; Dodecylphosphocholine-regulated intramolecular conformational dynamics of Ykt6 has been reported. Publication Status: Online-Only, [RefSeq, PubMed]; The un-lipidated rat Ykt6 adopts five major conformational states., [RefSeq, PubMed]; The ykt6 particles/aggregates may represent ykt6 engaged in a non-SNARE function(s) or else nonfunctional, stored and/or excess ykt6., [RefSeq, PubMed]; Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment (By similarity). Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5 (PubMed:11323436). Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5 (By similarity). Has a S-palmitoyl transferase activity (By similarity). Essential for the structural and functional organization of the Golgi apparatus (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35487", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.3.1.70", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.70", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0005484 SNAP receptor activity;GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0006903 vesicle targeting;GO:0006904 vesicle docking involved in exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q5EGY4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q642B9-1", "uniprot_id": [ { "id": "ZNF18_RAT", "url": "https://www.uniprot.org/uniprot/Q642B9", "type": "external" } ], "mass": 62947.0, "length": 556, "protein_name": "Zinc finger protein 18", "gene_name": "Zfp18; Znf18", "organism": "Rat", "refseq_name": "zinc finger protein 18", "refseq_ac": [ { "id": "NP_001012008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012008", "type": "external" } ], "gene_names_uniprotkb": "Zfp18; Znf18; Zfp18; Zfp535", "gene_names_refseq": "Zfp18; Zfp535; Zkscan6; Znf18", "protein_names_uniprotkb": "Zinc finger protein 18; Zinc finger protein 535", "protein_names_refseq": "zinc finger protein 18; zinc finger protein 535; zinc finger with KRAB and SCAN domains 6", "tax_id": 10116, "disease": "", "pathway": " (rno:303226); (R-RNO-212436)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q642B9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5MYW4-1", "uniprot_id": [ { "id": "ZN667_RAT", "url": "https://www.uniprot.org/uniprot/Q5MYW4", "type": "external" } ], "mass": 70038.0, "length": 608, "protein_name": "Zinc finger protein 667", "gene_name": "Zfp667; Znf667", "organism": "Rat", "refseq_name": "zinc finger protein 667", "refseq_ac": [ { "id": "NP_001008557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008557", "type": "external" } ], "gene_names_uniprotkb": "Zfp667; Znf667; Mip1; Mipu1; Zfp667", "gene_names_refseq": "Mip1; Zfp667; Znf667", "protein_names_uniprotkb": "Zinc finger protein 667; Myocardial ischemic preconditioning up-regulated protein 1", "protein_names_refseq": "myocardial ischemic preconditioning up-regulated protein 1; myocardial ischemic preconditioning upregulated 1; zinc finger protein 667", "tax_id": 10116, "disease": "", "pathway": " (rno:308326); (R-RNO-212436)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "19015817;19352546;19649394;20488243;24349374;25397408", "class_list": "", "function": "Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases., [UniProtKB, UniProtKB]; May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]; Mipu1 is involved in HIF-1-mediate cytoprotection by inhibiting the expression of Bax and interfering activation of mitochondrial apoptotic pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Results found that Mipu1 was highly expressed in the heart and brain of rats and was localized in the nucleus of H9c2 myogenic cells and lay the foundation for further study of the biological functions of Mipu1., [RefSeq, PubMed]; Results indicate that the GC boxes are essential for the activity of the Mipu1 minimal promoter activity, [RefSeq, PubMed]; The H(2)O(2)-induced up-regulation of Mipu1 in H9c2 cardiomyocytes was mediated by cAMP/PKA-dependent CREB activation., [RefSeq, PubMed]; These results suggested that Mipu1 protein might act as a transcriptional repressor in mitogen-activated protein kinase (MAPK) signaling pathway to mediate cellular functions, [RefSeq, PubMed]; ZNF667 that confers cytoprotection is a novel regulator of the rat Bax gene. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009891 positive regulation of biosynthetic process;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5MYW4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62806-1", "uniprot_id": [ { "id": "ZN148_RAT", "url": "https://www.uniprot.org/uniprot/Q62806", "type": "external" } ], "mass": 88748.0, "length": 794, "protein_name": "Zinc finger protein 148", "gene_name": "Zfp148; Znf148", "organism": "Rat", "refseq_name": "zinc finger protein 148", "refseq_ac": [ { "id": "NP_113803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113803", "type": "external" } ], "gene_names_uniprotkb": "Zfp148; Znf148; Zbp89; Zfp148", "gene_names_refseq": "Zbp-89; Zfp148; Znf148", "protein_names_uniprotkb": "Zinc finger protein 148; Transcription factor ZBP-89; Zinc finger DNA-binding protein 89", "protein_names_refseq": "transcription factor ZBP-89; zinc finger DNA-binding protein 89; zinc finger protein 148", "tax_id": 10116, "disease": "", "pathway": " (rno:58820)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14654702;17560543;22673903;8943318", "class_list": "", "function": "Ataxia telangiectasia mutated protein phosphorylation of ZBP-89 contributes to Histone deacetylase inhibitors induction of p21(waf1) gene expression, [RefSeq, PubMed]; Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; ZBP-89 binds directly to the STAT1 promoter G-rich element Erratum:[Nucleic Acids Res. 2004 Feb 24;32(4):1615], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0003690 double-stranded DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62806-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63081-1", "uniprot_id": [ { "id": "VATL_RAT", "url": "https://www.uniprot.org/uniprot/P63081", "type": "external" } ], "mass": 15808.0, "length": 155, "protein_name": "V-type proton ATPase 16 kDa proteolipid subunit c", "gene_name": "Atp6v0c", "organism": "Rat", "refseq_name": "V-type proton ATPase 16 kDa proteolipid subunit c", "refseq_ac": [ { "id": "NP_570836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570836", "type": "external" } ], "gene_names_uniprotkb": "Atp6v0c; Atp6c; Atp6l; Atpl", "gene_names_refseq": "Atp6c; Atp6l; Atp6v0c", "protein_names_uniprotkb": "V-type proton ATPase 16 kDa proteolipid subunit c; V-ATPase 16 kDa proteolipid subunit c; Vacuolar proton pump 16 kDa proteolipid subunit c", "protein_names_refseq": "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit C; ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c; ATPase, H+ transporting, lysosomal V0 subunit C; V-ATPase 16 kDa proteolipid subunit c; V-ATPase 16 kDa proteolipid subunit; V-type proton ATPase 16 kDa proteolipid subunit c; V-type proton ATPase 16 kDa proteolipid subunit; vacuolar proton pump 16 kDa proteolipid subunit c; vacuolar proton pump 16 kDa proteolipid subunit", "tax_id": 10116, "disease": "early-onset epilepsy 3 (Disease Ontology:DOID:0070472); intellectual disability (Disease Ontology:DOID:1059); epilepsy (Disease Ontology:DOID:1826); thyroid gland carcinoma (Disease Ontology:DOID:3963)", "pathway": " (rno:170667); (R-RNO-1222556); (R-RNO-6798695); (R-RNO-77387); (R-RNO-917977); (R-RNO-9639288); (R-RNO-983712)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "1400263;30155790;32165585", "class_list": "", "function": "Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB]; Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; V-ATPase c-subunit V0c is a key element in modulating neurotransmission and that its specific inactivation rapidly inhibited neurotransmission., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P23967", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0033176 proton-transporting V-type ATPase complex;GO:0016020 membrane;GO:0030665 clathrin-coated vesicle membrane;GO:0030672 synaptic vesicle membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0030177 positive regulation of Wnt signaling pathway;GO:0097401 synaptic vesicle lumen acidification;GO:1904093 negative regulation of autophagic cell death", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P63081-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLL0-1", "uniprot_id": [ { "id": "TCEA1_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLL0", "type": "external" } ], "mass": 33893.0, "length": 301, "protein_name": "Transcription elongation factor A protein 1", "gene_name": "Tcea1", "organism": "Rat", "refseq_name": "transcription elongation factor A protein 1", "refseq_ac": [ { "id": "NP_001020906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020906", "type": "external" } ], "gene_names_uniprotkb": "Tcea1; Tcea1l1", "gene_names_refseq": "GTF2S; SII; TCEA; TF2S; TFIIS; Tcea1", "protein_names_uniprotkb": "Transcription elongation factor A protein 1; Transcription elongation factor S-II protein 1", "protein_names_refseq": "transcription elongation factor A (SII) 1; transcription elongation factor A protein 1; transcription elongation factor S-II protein 1; transcription factor IIS", "tax_id": 10116, "disease": "", "pathway": " (rno:362479); (R-RNO-112382); (R-RNO-674695); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6796648); (R-RNO-75955)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030218 erythrocyte differentiation;GO:0045893 positive regulation of DNA-templated transcription;GO:0006368 transcription elongation by RNA polymerase II;GO:0061014 positive regulation of mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KLL0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84903-1", "uniprot_id": [ { "id": "STIM1_RAT", "url": "https://www.uniprot.org/uniprot/P84903", "type": "external" } ], "mass": 77449.0, "length": 685, "protein_name": "Stromal interaction molecule 1", "gene_name": "Stim1", "organism": "Rat", "refseq_name": "stromal interaction molecule 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001101966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101966", "type": "external" } ], "gene_names_uniprotkb": "Stim1; Sim", "gene_names_refseq": "Stim1", "protein_names_uniprotkb": "Stromal interaction molecule 1", "protein_names_refseq": "stromal interaction molecule 1 isoform 1 precursor", "tax_id": 10116, "disease": "Stormorken syndrome (Disease Ontology:DOID:0060354); tubular aggregate myopathy 1 (Disease Ontology:DOID:0080089); immunodeficiency 10 (Disease Ontology:DOID:0111970); stomach cancer (Disease Ontology:DOID:10534); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); colorectal cancer (Disease Ontology:DOID:9256); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:361618); (R-RNO-5578775); (R-RNO-983695)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "16208375;16766533;17224452;21454685;22673903;22992728;34173958;34685680;34995919;37711097;38514055;38843836", "class_list": "", "function": "Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels. Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry. Involved in enamel formation. Plays a role in regulating the type I interferon response by retaining the signaling adapter STING at the endoplasmic reticulum., [UniProtKB, PubMed, UniProtKB]; Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in activation of SOC channel in response to internal Ca2+ store depletion Erratum:[J Biol Chem. 2007 Sep 14;282(37):27556. Gill, Donald [corrected to Gill, Donald L]], [RefSeq, PubMed]; Genotypes of Stim1 and the proximal region on chromosome 1 exert opposite effects on stroke susceptibility in stroke-prone spontaneously hypertensive rat., [RefSeq, PubMed]; Mapping the Proximity Interaction Network of STIM1 Reveals New Mechanisms of Cytoskeletal Regulation. Publication Status: Online-Only, [RefSeq, PubMed]; Na(+)/Ca(2+) exchanger isoform 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) are recruited by STIM1 to mediate Store-Operated Calcium Entry in primary cortical neurons., [RefSeq, PubMed]; Proposal that STIM1 functions as the missing link between Ca2+ store depletion and store-operated calcium influx, serving as a Ca2+ sensor that translocates upon store depletion to the plasma membrane to activate CRAC channels, [RefSeq, PubMed]; STIM1, STIM2, and PDI Participate in Cellular Fate Decisions in Low Energy Availability Induced by 3-NP in Male Rats., [RefSeq, PubMed]; Suppression of store-operated channels function by Orai1 overexpression likely reflects a required stoichiometry between STIM1 and Orai1, [RefSeq, PubMed]; The Role and Mechanism of STIM1/Orai1-Regulated Ca[2+] Influx in Myocardial Hypertrophy in Type 2 Diabetes Mellitus., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0005246 calcium channel regulator activity;GO:0005509 calcium ion binding;GO:0051010 microtubule plus-end binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0030426 growth cone;GO:0044853 plasma membrane raft", "go_biological_process": "GO:0007207 phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway;GO:0006874 intracellular calcium ion homeostasis;GO:0045766 positive regulation of angiogenesis;GO:0051924 regulation of calcium ion transport;GO:0006812 monoatomic cation transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P84903-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5J3M4-1", "uniprot_id": [ { "id": "V1R94_RAT", "url": "https://www.uniprot.org/uniprot/Q5J3M4", "type": "external" } ], "mass": 37166.0, "length": 326, "protein_name": "Vomeronasal type-1 receptor 94", "gene_name": "Vom1r94", "organism": "Rat", "refseq_name": "vomeronasal type-1 receptor 94", "refseq_ac": [ { "id": "NP_001008915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008915", "type": "external" } ], "gene_names_uniprotkb": "Vom1r94; V1ra13", "gene_names_refseq": "V1ra13; V1ra2; Vom1r94", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 94; Vomeronasal type-1 receptor A13", "protein_names_refseq": "vomernasal 1 receptor Vom1r94; vomeronasal 1 receptor, A2; vomeronasal 1 receptor, a13; vomeronasal V1r-type receptor V1ra13; vomeronasal type-1 receptor 94; vomeronasal type-1 receptor A13", "tax_id": 10116, "disease": "", "pathway": " (rno:494265)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5J3M4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2P3-1", "uniprot_id": [ { "id": "ZFN2A_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2P3", "type": "external" } ], "mass": 19267.0, "length": 171, "protein_name": "AN1-type zinc finger protein 2A", "gene_name": "Zfand2a", "organism": "Rat", "refseq_name": "AN1-type zinc finger protein 2A", "refseq_ac": [ { "id": "NP_001008364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008364", "type": "external" } ], "gene_names_uniprotkb": "Zfand2a", "gene_names_refseq": "RGD1310991; Zfand2a", "protein_names_uniprotkb": "AN1-type zinc finger protein 2A", "protein_names_refseq": "AN1-type zinc finger protein 2A; zinc finger, AN1-type domain 2A", "tax_id": 10116, "disease": "", "pathway": " (rno:360772)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0000502 proteasome complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0045047 protein targeting to ER;GO:0071243 cellular response to arsenic-containing substance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2P3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI57-1", "uniprot_id": [ { "id": "TTL10_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI57", "type": "external" } ], "mass": 77081.0, "length": 679, "protein_name": "Protein polyglycylase TTLL10", "gene_name": "Ttll10", "organism": "Rat", "refseq_name": "protein polyglycylase TTLL10 isoform 2", "refseq_ac": [ { "id": "NP_001019929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019929", "type": "external" } ], "gene_names_uniprotkb": "Ttll10", "gene_names_refseq": "Ttll10", "protein_names_uniprotkb": "Protein polyglycylase TTLL10; 6.3.2.-; Tubulin--tyrosine ligase-like protein 10", "protein_names_refseq": "protein polyglycylase TTLL10 isoform 2; protein polyglycylase TTLL10; tubulin tyrosine ligase-like family, member 10; tubulin--tyrosine ligase-like protein 10", "tax_id": 10116, "disease": "", "pathway": " (rno:298692); (R-RNO-8955332)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Polyglycylase which modifies both tubulin and non-tubulin proteins, generating polyglycine side chains of variable lengths on the gamma-carboxyl groups of specific glutamate residues of target proteins. Involved in the elongation step rather than the initiation step of the polyglycylation reaction. Polyglycylates alpha-tubulin and beta-tubulin. Polyglycylates non-tubulin proteins such as nucleosome assembly protein NAP1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V8F2", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0070735 protein-glycine ligase activity;GO:0070737 protein-glycine ligase activity, elongating;GO:0016881 acid-amino acid ligase activity", "go_cellular_component": "GO:0005874 microtubule;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton;GO:0005930 axoneme", "go_biological_process": "GO:0018094 protein polyglycylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI57-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B725-1", "uniprot_id": [ { "id": "ZBT24_RAT", "url": "https://www.uniprot.org/uniprot/Q3B725", "type": "external" } ], "mass": 78207.0, "length": 705, "protein_name": "Zinc finger and BTB domain-containing protein 24", "gene_name": "Zbtb24", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zbtb24; Bif1; Znf450", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 24; Bone morphogenetic protein-induced factor 1; Zinc finger protein 450", "protein_names_refseq": "", "tax_id": 10116, "disease": "immunodeficiency-centromeric instability-facial anomalies syndrome (Disease Ontology:DOID:0090007); immunodeficiency-centromeric instability-facial anomalies syndrome 2 (Disease Ontology:DOID:0090009)", "pathway": " (rno:365590)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15526281", "class_list": "", "function": "May be involved in BMP2-induced transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0002682 regulation of immune system process;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3B725-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VGK2-1", "uniprot_id": [ { "id": "TT39C_RAT", "url": "https://www.uniprot.org/uniprot/Q0VGK2", "type": "external" } ], "mass": 58978.0, "length": 522, "protein_name": "Tetratricopeptide repeat protein 39C", "gene_name": "Ttc39c", "organism": "Rat", "refseq_name": "tetratricopeptide repeat protein 39C isoform 1", "refseq_ac": [ { "id": "NP_001070699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070699", "type": "external" } ], "gene_names_uniprotkb": "Ttc39c", "gene_names_refseq": "Ttc39c", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 39C; TPR repeat protein 39C", "protein_names_refseq": "TPR repeat protein 39C; tetratricopeptide repeat protein 39C isoform 1; tetratricopeptide repeat protein 39C", "tax_id": 10116, "disease": "", "pathway": " (rno:686179)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0032474 otolith morphogenesis;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VGK2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97615-1", "uniprot_id": [ { "id": "THIOM_RAT", "url": "https://www.uniprot.org/uniprot/P97615", "type": "external" } ], "mass": 18232.0, "length": 166, "protein_name": "Thioredoxin, mitochondrial", "gene_name": "Txn2", "organism": "Rat", "refseq_name": "thioredoxin, mitochondrial precursor", "refseq_ac": [ { "id": "NP_445783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445783", "type": "external" } ], "gene_names_uniprotkb": "Txn2; Trx2", "gene_names_refseq": "Txn2", "protein_names_uniprotkb": "Thioredoxin, mitochondrial; MTRX; Mt-Trx; Thioredoxin-2", "protein_names_refseq": "MTRX; mt-Trx; thioredoxin, mitochondrial precursor; thioredoxin, mitochondrial", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency 29 (Disease Ontology:DOID:0111501)", "pathway": " (rno:79462); (R-RNO-1614558); (R-RNO-3299685)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12577622;23949220;25996168;26975474;28529127;30236513;9006939", "class_list": "", "function": "Age-related changes in Trx2 and the TXNIP-Trx2-ASK1 signal pathway in the auditory cortex, [RefSeq, PubMed]; Cerebral ischemia/reperfusion mediates procaspase-3 denitrosylation and activation through GluR6-FasL-Trx2 pathway, which leads to neuronal apoptosis and cell death. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that the redox state of cyclophilin D was stimulated by thioredoxin 1 and 2 and peroxiredoxin 3 in heart mitochondria. Publication Status: Online-Only, [RefSeq, PubMed]; Estradiol-17beta upregulation of both PRX3 and TRX2 in the white adipose tissue, but not in the brown adipose tissue could play a key role in the sex dimorphism reported in the antioxidant defense of the white adipose tissue in order to alleviate the detrimental effect of the oxidative stress., [RefSeq, PubMed]; Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability (By similarity). Is involved in various redox reactions including the reduction of protein disulfide bonds, through the reversible oxidation of its active center dithiol to a disulfide (PubMed:9006939)., [UniProtKB, PubMed, UniProtKB]; Loss of TXN2 alters mitochondrial respiratory function and induces cardiomyocyte hypertrophy., [RefSeq, PubMed]; TRx2 has a role scavenging reactive oxygen species in mitochondria and is involved in regulating apoptotic cascades, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0015035 protein-disulfide reductase activity;GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor", "go_cellular_component": "GO:0005739 mitochondrion;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0001666 response to hypoxia;GO:0031669 cellular response to nutrient levels;GO:0009725 response to hormone;GO:0009749 response to glucose", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P97615-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q498S6-1", "uniprot_id": [ { "id": "ZCHC2_RAT", "url": "https://www.uniprot.org/uniprot/Q498S6", "type": "external" } ], "mass": 124732.0, "length": 1168, "protein_name": "Zinc finger CCHC domain-containing protein 2", "gene_name": "Zcchc2", "organism": "Rat", "refseq_name": "zinc finger CCHC domain-containing protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001257971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257971", "type": "external" } ], "gene_names_uniprotkb": "Zcchc2", "gene_names_refseq": "Tnfrsf11a; Zcchc2", "protein_names_uniprotkb": "Zinc finger CCHC domain-containing protein 2", "protein_names_refseq": "tumor necrosis factor receptor superfamily, member 11a; zinc finger CCHC domain-containing protein 2 isoform 2; zinc finger CCHC domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:304695)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q498S6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U1V9-1", "uniprot_id": [ { "id": "TSN31_RAT", "url": "https://www.uniprot.org/uniprot/Q5U1V9", "type": "external" } ], "mass": 22660.0, "length": 210, "protein_name": "Tetraspanin-31", "gene_name": "Tspan31", "organism": "Rat", "refseq_name": "tetraspanin-31", "refseq_ac": [ { "id": "NP_001008379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008379", "type": "external" } ], "gene_names_uniprotkb": "Tspan31; Sas", "gene_names_refseq": "Sas; Tspan31", "protein_names_uniprotkb": "Tetraspanin-31; Sarcoma-amplified sequence homolog; Tspan-31", "protein_names_refseq": "sarcoma amplified sequence; sarcoma-amplified sequence homolog; tetraspanin-31; tspan-31", "tax_id": 10116, "disease": "", "pathway": " (rno:362890)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U1V9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05474-1", "uniprot_id": [ { "id": "UBIM_RAT", "url": "https://www.uniprot.org/uniprot/Q05474", "type": "external" } ], "mass": 7742.0, "length": 74, "protein_name": "Ubiquitin-like protein FUBI", "gene_name": "Faul1; Fau; LOC102548890; LOC102550534", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Faul1; Fau; LOC102548890; LOC102550534; AABR07004876.1; AABR07005572.2; Faul1; Fau; LOC102548890; LOC102553078; LOC687780", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin-like protein FUBI", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:102548890); (rno:29752); (rno:687780); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 15, "publication_count": 1, "publication_id_list": "8394356", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0016567 protein ubiquitination;GO:0002227 innate immune response in mucosa;GO:0019941 modification-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q05474-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPH4-1", "uniprot_id": [ { "id": "ZN414_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPH4", "type": "external" } ], "mass": 31967.0, "length": 299, "protein_name": "Zinc finger protein 414", "gene_name": "Pram1; Zfp414; Znf414", "organism": "Rat", "refseq_name": "zinc finger protein 414 isoform 2", "refseq_ac": [ { "id": "NP_001009664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009664", "type": "external" } ], "gene_names_uniprotkb": "Pram1; Zfp414; Znf414; Pram1; Zfp414", "gene_names_refseq": "RGD1308123; Zfp414; Znf414", "protein_names_uniprotkb": "Zinc finger protein 414", "protein_names_refseq": "zinc finger protein 414 isoform 2", "tax_id": 10116, "disease": "", "pathway": " (rno:299647)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007229 integrin-mediated signaling pathway;GO:0043313 regulation of neutrophil degranulation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PPH4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63454-1", "uniprot_id": [ { "id": "MK04_RAT", "url": "https://www.uniprot.org/uniprot/Q63454", "type": "external" } ], "mass": 31162.0, "length": 274, "protein_name": "Mitogen-activated protein kinase 4", "gene_name": "Mapk4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mapk4; Prkm4", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitogen-activated protein kinase 4; 2.7.11.24; ERK-4; Extracellular signal-regulated kinase 4; MAP kinase 4; MAP kinase isoform p63; MAPK 4; MNK2; p63-MAPK", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:54268); (R-RNO-5687128)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;8875888", "class_list": "", "function": "Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0072584 caveolin-mediated endocytosis;GO:2000641 regulation of early endosome to late endosome transport;GO:0045727 positive regulation of translation;GO:0051493 regulation of cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63454-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U3Z3-1", "uniprot_id": [ { "id": "ISOC2_RAT", "url": "https://www.uniprot.org/uniprot/Q5U3Z3", "type": "external" } ], "mass": 23157.0, "length": 210, "protein_name": "Isochorismatase domain-containing protein 2", "gene_name": "Isoc2b; Isoc2", "organism": "Rat", "refseq_name": "isochorismatase domain-containing protein 2", "refseq_ac": [ { "id": "NP_001008368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008368", "type": "external" } ], "gene_names_uniprotkb": "Isoc2b; Isoc2; Isoc2b", "gene_names_refseq": "Isoc2b; Isoc2; RGD1309062", "protein_names_uniprotkb": "Isochorismatase domain-containing protein 2", "protein_names_refseq": "isochorismatase domain containing 2; isochorismatase domain-containing protein 2, mitochondrial; isochorismatase domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:361501)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0031648 protein destabilization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U3Z3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H70-1", "uniprot_id": [ { "id": "IL33_RAT", "url": "https://www.uniprot.org/uniprot/Q66H70", "type": "external" } ], "mass": 29486.0, "length": 264, "protein_name": "Interleukin-33", "gene_name": "Il33", "organism": "Rat", "refseq_name": "interleukin-33", "refseq_ac": [ { "id": "NP_001014188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014188", "type": "external" } ], "gene_names_uniprotkb": "Il33", "gene_names_refseq": "Il33; RGD1311155", "protein_names_uniprotkb": "Interleukin-33; IL-33", "protein_names_refseq": "IL-33; interleukin-33", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); obstructive sleep apnea (Disease Ontology:DOID:0050848); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); colitis (Disease Ontology:DOID:0060180); aortic atherosclerosis (Disease Ontology:DOID:10230); common cold (Disease Ontology:DOID:10459); pleural tuberculosis (Disease Ontology:DOID:106); Alzheimer's disease (Disease Ontology:DOID:10652); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); pulmonary edema (Disease Ontology:DOID:11396); paracoccidioidomycosis (Disease Ontology:DOID:12662); gout (Disease Ontology:DOID:13189); clonorchiasis (Disease Ontology:DOID:13767); candidiasis (Disease Ontology:DOID:1508); colon cancer (Disease Ontology:DOID:219); asthma (Disease Ontology:DOID:2841); tuberculosis (Disease Ontology:DOID:399); liver cirrhosis (Disease Ontology:DOID:5082); pulmonary hypertension (Disease Ontology:DOID:6432); peptic ulcer disease (Disease Ontology:DOID:750); herpes simplex (Disease Ontology:DOID:8566); ulcerative colitis (Disease Ontology:DOID:8577); diabetes mellitus (Disease Ontology:DOID:9351); acute myocardial infarction (Disease Ontology:DOID:9408); allergic asthma (Disease Ontology:DOID:9415); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (rno:361749); (R-RNO-1257604); (R-RNO-5689880); (R-RNO-6811558); (R-RNO-9014843)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "29393594;35452731;36110250;36768322;38142925;38724005", "class_list": "", "function": "Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity). Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Electroacupuncture prevents the development or establishment of chronic pain via IL-33/ST2 signaling in hyperalgesic priming model rats., [RefSeq, PubMed]; Exploration of potential mechanism of interleukin-33 up-regulation caused by 1,4-naphthoquinone black carbon in RAW264.7 cells., [RefSeq, PubMed]; IL-33 Participates in the Development of Esophageal Adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or pro-inflammatory activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence., [RefSeq, PubMed]; Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to Obesity in Zucker Fatty Rats. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0002112 interleukin-33 receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030133 transport vesicle", "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0032754 positive regulation of interleukin-5 production;GO:0043032 positive regulation of macrophage activation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q66H70-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7F0-1", "uniprot_id": [ { "id": "TTC23_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7F0", "type": "external" } ], "mass": 50271.0, "length": 446, "protein_name": "Tetratricopeptide repeat protein 23", "gene_name": "Ttc23", "organism": "Rat", "refseq_name": "tetratricopeptide repeat protein 23", "refseq_ac": [ { "id": "NP_001020852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020852", "type": "external" } ], "gene_names_uniprotkb": "Ttc23", "gene_names_refseq": "RGD1310409; Ttc23", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 23; TPR repeat protein 23", "protein_names_refseq": "TPR repeat protein 23; tetratricopeptide repeat protein 23", "tax_id": 10116, "disease": "", "pathway": " (rno:308708)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Participates positively in the ciliary Hedgehog (Hh) signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V7F0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZV2-1", "uniprot_id": [ { "id": "SFT2B_RAT", "url": "https://www.uniprot.org/uniprot/Q4FZV2", "type": "external" } ], "mass": 17511.0, "length": 157, "protein_name": "Vesicle transport protein SFT2B", "gene_name": "Sft2d2", "organism": "Rat", "refseq_name": "vesicle transport protein SFT2B", "refseq_ac": [ { "id": "NP_001029183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029183", "type": "external" } ], "gene_names_uniprotkb": "Sft2d2", "gene_names_refseq": "RGD1310623; Sft2d2", "protein_names_uniprotkb": "Vesicle transport protein SFT2B; SFT2 domain-containing protein 2", "protein_names_refseq": "SFT2 domain-containing protein 2; vesicle transport protein SFT2B", "tax_id": 10116, "disease": "", "pathway": " (rno:360868)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4FZV2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64686-1", "uniprot_id": [ { "id": "SIA7C_RAT", "url": "https://www.uniprot.org/uniprot/Q64686", "type": "external" } ], "mass": 35150.0, "length": 305, "protein_name": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3", "gene_name": "St6galnac3", "organism": "Rat", "refseq_name": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3", "refseq_ac": [ { "id": "NP_061996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061996", "type": "external" } ], "gene_names_uniprotkb": "St6galnac3; Siat7c", "gene_names_refseq": "Siat7c; St6galnac3", "protein_names_uniprotkb": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; 2.4.3.7; GalNAc alpha-2,6-sialyltransferase III; SIAT7-C; ST6GalNAc III; ST6GalNAcIII; STY; Sialyltransferase 7C", "protein_names_refseq": "((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C; SIAT7-C; ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6 GalNAc alpha-2,6-sialyltransferase 3; ST6GalNAc III; ST6GalNAcIII; STY; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; galNAc alpha-2,6-sialyltransferase III; sialyltransferase 7 ((alpha-N-acetylneuraminyl 23-betagalactosyl-13)-N-acetyl galactosaminide alpha-26-sialyltransferase) C; sialyltransferase 7c", "tax_id": 10116, "disease": "renal agenesis (Disease Ontology:DOID:14766)", "pathway": " (rno:29758); (R-RNO-4085001); (R-RNO-977068)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8631773", "class_list": "glycogene;glycosyltransferase", "function": "Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:8631773). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.7", "type": "external" }, { "id": "2.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.3", "type": "external" } ], "go_molecular_function": "GO:0008373 sialyltransferase activity;GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity;GO:0047290 alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006687 glycosphingolipid metabolic process;GO:0009311 oligosaccharide metabolic process;GO:0009100 glycoprotein metabolic process;GO:0006677 glycosylceramide metabolic process", "synthesized_glycan_count": 550, "hit_score": 0.2, "record_id": "Q64686-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQU6-1", "uniprot_id": [ { "id": "SPF30_RAT", "url": "https://www.uniprot.org/uniprot/Q4QQU6", "type": "external" } ], "mass": 26783.0, "length": 238, "protein_name": "Survival of motor neuron-related-splicing factor 30", "gene_name": "Smndc1", "organism": "Rat", "refseq_name": "survival of motor neuron-related-splicing factor 30", "refseq_ac": [ { "id": "NP_001020571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020571", "type": "external" } ], "gene_names_uniprotkb": "Smndc1; Spf30", "gene_names_refseq": "Smndc1", "protein_names_uniprotkb": "Survival of motor neuron-related-splicing factor 30; Survival motor neuron domain-containing protein 1", "protein_names_refseq": "survival motor neuron domain-containing protein 1; survival of motor neuron-related-splicing factor 30", "tax_id": 10116, "disease": "", "pathway": " (rno:287768); (R-RNO-72163); (R-RNO-9770562); (R-RNO-9943411)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in spliceosome assembly (By similarity)., [UniProtKB, UniProtKB]; Involved in spliceosome assembly., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KM88", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0006915 apoptotic process;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4QQU6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62916-1", "uniprot_id": [ { "id": "TF2B_RAT", "url": "https://www.uniprot.org/uniprot/P62916", "type": "external" } ], "mass": 34819.0, "length": 316, "protein_name": "Transcription initiation factor IIB", "gene_name": "Gtf2b", "organism": "Rat", "refseq_name": "transcription initiation factor IIB", "refseq_ac": [ { "id": "NP_112303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112303", "type": "external" } ], "gene_names_uniprotkb": "Gtf2b", "gene_names_refseq": "Gtf2b", "protein_names_uniprotkb": "Transcription initiation factor IIB; 2.3.1.48; General transcription factor TFIIB; RNA polymerase II alpha initiation factor", "protein_names_refseq": "RNA polymerase II alpha initiation factor; general transcription factor TFIIB; transcription initiation factor IIB", "tax_id": 10116, "disease": "", "pathway": " (rno:81673); (R-RNO-674695); (R-RNO-6807505); (R-RNO-73776); (R-RNO-73779); (R-RNO-75953); (R-RNO-76042)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "1620622;23264107", "class_list": "", "function": "General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter-specific regions. Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element. Modulates transcription start site selection. Also exhibits autoacetyltransferase activity that contributes to the activated transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Spatiotemporal changes of TFIIB expression suggest that this protein may play a role in the degenerative process of RGCs by light-induced damage in the retina., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P29053", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000793 condensed chromosome", "go_biological_process": "GO:0019083 viral transcription;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006473 protein acetylation;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P62916-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82450-1", "uniprot_id": [ { "id": "SIAE_RAT", "url": "https://www.uniprot.org/uniprot/P82450", "type": "external" } ], "mass": 60466.0, "length": 542, "protein_name": "Sialate O-acetylesterase", "gene_name": "Siae", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Siae; Ysg2", "gene_names_refseq": "", "protein_names_uniprotkb": "Sialate O-acetylesterase; 3.1.1.53; SIAE; Sialic acid-specific 9-O-acetylesterase; Yolk sac protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "autoimmune disease (Disease Ontology:DOID:417)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "2808434;8486688", "class_list": "", "function": "Catalyzes the removal of O-acetyl ester groups from position 9 of the free diacetylated sialate N-acetyl-9-O-acetylneuraminate (Neu5,9Ac2) in the cytosol and of the diacetylated sialate residues of sialylglycoconjugates in the lysosomes (Probable). Together with the sialate-O-acetyltransferase they regulate the balance of acetylated sialoglycoconjugates, key players in various processes such as cell-cell interactions, host-pathogen recognition, and tumor antigenicity (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.53", "type": "external" } ], "go_molecular_function": "GO:0001681 sialate O-acetylesterase activity;GO:0106330 sialate 9-O-acetylesterase activity", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0002682 regulation of immune system process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P82450-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXQ7-1", "uniprot_id": [ { "id": "DC11L_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXQ7", "type": "external" } ], "mass": 95625.0, "length": 822, "protein_name": "Dynein regulatory complex subunit 11-like", "gene_name": "Drc11l", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Drc11l; Iqca1l; Iqca1p1; LOC499971", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein regulatory complex subunit 11-like; IQ and AAA domain-containing protein 1-like; Protein IQCA1P1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:499971)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXQ7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97588-1", "uniprot_id": [ { "id": "SMAD1_RAT", "url": "https://www.uniprot.org/uniprot/P97588", "type": "external" } ], "mass": 52713.0, "length": 468, "protein_name": "SMAD family member 1", "gene_name": "Smad1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Smad1; Mad1; Madh1", "gene_names_refseq": "", "protein_names_uniprotkb": "SMAD family member 1; MAD homolog 1; Mothers against DPP homolog 1; Mothers against decapentaplegic homolog 1; SMAD 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); nephrotic syndrome (Disease Ontology:DOID:1184); male infertility (Disease Ontology:DOID:12336); glomerulonephritis (Disease Ontology:DOID:2921); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:25671); (R-RNO-201451); (R-RNO-5689880)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "8917532;9989785", "class_list": "", "function": "Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis. Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form an heteromeric complex which translocates into the nucleus acting as transcription factor. In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70520", "ec_number_list": [], "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002051 osteoblast fate commitment;GO:1903672 positive regulation of sprouting angiogenesis;GO:0001710 mesodermal cell fate commitment;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P97588-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03191-1", "uniprot_id": [ { "id": "TFF3_RAT", "url": "https://www.uniprot.org/uniprot/Q03191", "type": "external" } ], "mass": 8944.0, "length": 81, "protein_name": "Trefoil factor 3", "gene_name": "Tff3", "organism": "Rat", "refseq_name": "trefoil factor 3 precursor", "refseq_ac": [ { "id": "NP_037174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037174", "type": "external" } ], "gene_names_uniprotkb": "Tff3; Itf", "gene_names_refseq": "ITF; Tff3", "protein_names_uniprotkb": "Trefoil factor 3; Intestinal trefoil factor; Polypeptide P1.B; rITF; rP1.B", "protein_names_refseq": "intestinal trefoil factor; polypeptide P1.B; trefoil factor 3 precursor; trefoil factor 3, intestinal", "tax_id": 10116, "disease": "pre-malignant neoplasm (Disease Ontology:DOID:0060071); prostate cancer (Disease Ontology:DOID:10283); colon cancer (Disease Ontology:DOID:219)", "pathway": " (rno:25563)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "1439565;1637322;1763017;19076725;25504043;29453360;29723130;7721858;8454642;8750886;9299425", "class_list": "", "function": "ITF can improve cytomorphosis ability for promoting cell migration with limited effect on cell proliferation, which can be enhanced with addition of mucin. The main mechanism of ITF in maintaining intestinal mucosal barrier may be attributed to acceleration of cell migration. Erratum:[Sci Rep. 2020 Jul 24;10(1):12741. doi: 10.1038/s41598-020-69648-x. PMID: 32704055] Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The expression in activated microglial cells, which is demonstrated here for the first time, points towards a possible function for Tff3 in immune reactions in the CNS, [RefSeq, PubMed]; These results suggest that TFF3 may promote adhesion and spreading of cells to accelerate beta-cell maturation. This study indicates a functional role for TFF3 in pancreatic beta-cell maturation in the perinatal period, which is altered by low protein diet during gestation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q68FZ2", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0010906 regulation of glucose metabolic process;GO:0030277 maintenance of gastrointestinal epithelium;GO:0043434 response to peptide hormone", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q03191-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03626-1", "uniprot_id": [ { "id": "MUG1_RAT", "url": "https://www.uniprot.org/uniprot/Q03626", "type": "external" } ], "mass": 165326.0, "length": 1487, "protein_name": "Murinoglobulin-1", "gene_name": "Mug1; Mug2", "organism": "Rat", "refseq_name": "murinoglobulin-1 precursor", "refseq_ac": [ { "id": "NP_075591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075591", "type": "external" } ], "gene_names_uniprotkb": "Mug1; Mug2; A1i3", "gene_names_refseq": "A1i3; Mug1", "protein_names_uniprotkb": "Murinoglobulin-1; Alpha-1 inhibitor 3 variant I; Alpha-X protein", "protein_names_refseq": "Murinoglobulin 1 homolog; alpha x protein; alpha-X protein; murinoglobulin-1 precursor; murinoglobulin-1-like; plasma proteinase inhibitor alpha-1-inhibitor III", "tax_id": 10116, "disease": "", "pathway": " (rno:497794)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1709877;24090084;2511184;2831216;32325114;34502162", "class_list": "", "function": "A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective., [UniProtKB]; Differential levels of Alpha-1-inhibitor III, Immunoglobulin heavy chain variable region, and Hypertrophied skeletal muscle protein GTF3 in rat mammary tumorigenesis., [RefSeq, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q03310;Q63018;Q63020;Q63023;Q78DZ4;Q9JMK7", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0006953 acute-phase response;GO:0007566 embryo implantation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q03626-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVH7-1", "uniprot_id": [ { "id": "MEA1_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVH7", "type": "external" } ], "mass": 18584.0, "length": 174, "protein_name": "Male-enhanced antigen 1", "gene_name": "Mea1", "organism": "Rat", "refseq_name": "male-enhanced antigen 1", "refseq_ac": [ { "id": "NP_001037751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037751", "type": "external" } ], "gene_names_uniprotkb": "Mea1; Mea", "gene_names_refseq": "Mea1", "protein_names_uniprotkb": "Male-enhanced antigen 1; MEA-1", "protein_names_refseq": "MEA-1; male-enhanced antigen 1", "tax_id": 10116, "disease": "", "pathway": " (rno:685131)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May play an important role in spermatogenesis and/or testis development., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FVH7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00910-1", "uniprot_id": [ { "id": "SO2A1_RAT", "url": "https://www.uniprot.org/uniprot/Q00910", "type": "external" } ], "mass": 70387.0, "length": 644, "protein_name": "Solute carrier organic anion transporter family member 2A1", "gene_name": "Slco2a1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slco2a1; Matr1; Slc21a2", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 2A1; Matrin F/G 1; OATP2A1; PGT; PHOAR2; Prostaglandin transporter; SLC21A2; SLCO2A1; Solute carrier family 21 member 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "primary hypertrophic osteoarthropathy (Disease Ontology:DOID:14283)", "pathway": " (rno:24546); (R-RNO-879518)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10484490;11880322;11997327;15044627;15855165;20346915;2068100;7754369", "class_list": "", "function": "Mediates the transport of prostaglandins (PGs, mainly PGE2, PGE1, PGE3, PGF2alpha, PGD2, PGH2) and thromboxanes (thromboxane B2) across the cell membrane (PubMed:10484490, PubMed:11880322, PubMed:11997327, PubMed:15044627, PubMed:15855165, PubMed:20346915, PubMed:7754369). PGs and thromboxanes play fundamental roles in diverse functions such as intraocular pressure, gastric acid secretion, renal salt and water transport, vascular tone, and fever (PubMed:15044627). Plays a role in the clearance of PGs from the circulation through cellular uptake, which allows cytoplasmic oxidation and PG signal termination (PubMed:11997327, PubMed:15044627, PubMed:7754369). PG uptake is dependent upon membrane potential and involves exchange of a monovalent anionic substrate (PGs exist physiologically as an anionic monovalent form) with a stoichiometry of 1:1 for divalent anions or of 1:2 for monovalent anions (By similarity). Uses lactate, generated by glycolysis, as a counter-substrate to mediate PG influx and efflux (PubMed:11997327). Under nonglycolytic conditions, metabolites other than lactate might serve as counter-substrates (PubMed:11997327). Although the mechanism is not clear, this transporter can function in bidirectional mode (By similarity). When apically expressed in epithelial cells, it facilitates transcellular transport (also called vectorial release), extracting PG from the apical medium and facilitating transport across the cell toward the basolateral side, whereupon the PG exits the cell by simple diffusion (PubMed:11880322, PubMed:15044627, PubMed:15855165). In the renal collecting duct, regulates renal Na+ balance by removing PGE2 from apical medium (PGE2 EP4 receptor is likely localized to the luminal/apical membrane and stimulates Na+ resorption) and transporting it toward the basolateral membrane (where PGE2 EP1 and EP3 receptors inhibit Na+ resorption) (PubMed:15855165). Plays a role in endometrium during decidualization, increasing uptake of PGs by decidual cells (By similarity). Involved in critical events for ovulation (By similarity). Regulates extracellular PGE2 concentration for follicular development in the ovaries (By similarity). Expressed intracellularly, may contribute to vesicular uptake of newly synthesized intracellular PGs, thereby facilitating exocytotic secretion of PGs without being metabolized (By similarity). Essential core component of the major type of large-conductance anion channel, Maxi-Cl, which plays essential roles in inorganic anion transport, cell volume regulation and release of ATP and glutamate not only in physiological processes but also in pathological processes (By similarity). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015132 prostaglandin transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0005764 lysosome;GO:0009925 basal plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0043252 sodium-independent organic anion transport;GO:0015732 prostaglandin transport;GO:0006811 monoatomic ion transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q00910-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQT3-1", "uniprot_id": [ { "id": "GLYAT_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQT3", "type": "external" } ], "mass": 33899.0, "length": 296, "protein_name": "Glycine N-acyltransferase", "gene_name": "Glyat", "organism": "Rat", "refseq_name": "glycine N-acyltransferase", "refseq_ac": [ { "id": "NP_001009648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009648", "type": "external" } ], "gene_names_uniprotkb": "Glyat; Ab2-132", "gene_names_refseq": "Glyat", "protein_names_uniprotkb": "Glycine N-acyltransferase; 2.3.1.13; 2.3.1.71; AAc; Acyl-CoA:glycine N-acyltransferase; Aralkyl acyl-CoA N-acyltransferase; Aralkyl acyl-CoA:amino acid N-acyltransferase; Benzoyl-coenzyme A:glycine N-acyltransferase; Glycine N-benzoyltransferase; Liver regeneration-related protein LRRG067", "protein_names_refseq": "AAc; acyl-CoA:glycine N-acyltransferase; aralkyl acyl-CoA N-acyltransferase; aralkyl acyl-CoA:amino acid N-acyltransferase; benzoyl-coenzyme A:glycine N-acyltransferase; glycine N-acyltransferase; glycine N-benzoyltransferase; liver regeneration-related protein LRRG067", "tax_id": 10116, "disease": "", "pathway": " (rno:293779); (R-RNO-159424); (R-RNO-177128); (R-RNO-177135); (R-RNO-70895); (R-RNO-9749641)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "23230277", "class_list": "", "function": "Data indicate that the up-regulation of phase II detoxification in the DR group was confirmed by mRNA and protein expression levels of uridinediphospho-glucuronosyltransferase and glycine-N-acyltransferase in actual liver tissues., [RefSeq, PubMed]; Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TP56", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.13", "type": "external" }, { "id": "2.3.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.71", "type": "external" } ], "go_molecular_function": "GO:0047962 glycine N-benzoyltransferase activity;GO:0047961 glycine N-acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0009636 response to toxic substance;GO:0006544 glycine metabolic process;GO:0032787 monocarboxylic acid metabolic process;GO:1901787 benzoyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PQT3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62751-1", "uniprot_id": [ { "id": "IREB2_RAT", "url": "https://www.uniprot.org/uniprot/Q62751", "type": "external" } ], "mass": 104802.0, "length": 963, "protein_name": "Iron-responsive element-binding protein 2", "gene_name": "Ireb2", "organism": "Rat", "refseq_name": "iron-responsive element-binding protein 2", "refseq_ac": [ { "id": "NP_074054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_074054", "type": "external" } ], "gene_names_uniprotkb": "Ireb2; Irp2", "gene_names_refseq": "Ireb2; Irp2", "protein_names_uniprotkb": "Iron-responsive element-binding protein 2; IRE-BP 2; IRP2; Iron regulatory protein 2", "protein_names_refseq": "IRE-BP 2; iron regulatory protein 2; iron-responsive element-binding protein 2", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); iron deficiency anemia (Disease Ontology:DOID:11758); porphyria (Disease Ontology:DOID:13268); hyperinsulinism (Disease Ontology:DOID:2018); anemia (Disease Ontology:DOID:2355); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (rno:64831); (R-RNO-917937)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "22673903;35720183;7622457;7665579", "class_list": "", "function": "MiR-29a-3p in Exosomes from Heme Oxygenase-1 Modified Bone Marrow Mesenchymal Stem Cells Alleviates Steatotic Liver Ischemia-Reperfusion Injury in Rats by Suppressing Ferroptosis via Iron Responsive Element Binding Protein 2. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66HL4", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0001069 regulatory region RNA binding;GO:0003723 RNA binding;GO:0003994 aconitate hydratase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:1990910 response to hypobaric hypoxia;GO:0006417 regulation of translation;GO:0010043 response to zinc ion;GO:0071300 cellular response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62751-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641W7-1", "uniprot_id": [ { "id": "TTLL9_RAT", "url": "https://www.uniprot.org/uniprot/Q641W7", "type": "external" } ], "mass": 53963.0, "length": 461, "protein_name": "Probable tubulin polyglutamylase TTLL9", "gene_name": "Ttll9", "organism": "Rat", "refseq_name": "probable tubulin polyglutamylase TTLL9", "refseq_ac": [ { "id": "NP_001014073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014073", "type": "external" } ], "gene_names_uniprotkb": "Ttll9", "gene_names_refseq": "Ttll9", "protein_names_uniprotkb": "Probable tubulin polyglutamylase TTLL9; 6.3.2.-; Tubulin--tyrosine ligase-like protein 9", "protein_names_refseq": "probable tubulin polyglutamylase TTLL9; tubulin tyrosine ligase-like family, member 9; tubulin--tyrosine ligase-like protein 9", "tax_id": 10116, "disease": "", "pathway": " (rno:311548); (R-RNO-8955332)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins. Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity. Mediates tubulin polyglutamylation which induces establishment of microtubule heterogeneity in sperm flagella, thereby playing a role in normal motile flagella axoneme structure and sperm flagella beating pattern., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0070740 tubulin-glutamic acid ligase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0015631 tubulin binding;GO:0106438 protein-glutamic acid ligase activity, elongating", "go_cellular_component": "GO:0005874 microtubule;GO:0036064 ciliary basal body", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization;GO:0018095 protein polyglutamylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q641W7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM51-1", "uniprot_id": [ { "id": "TEFM_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM51", "type": "external" } ], "mass": 41538.0, "length": 365, "protein_name": "Transcription elongation factor, mitochondrial", "gene_name": "Tefm", "organism": "Rat", "refseq_name": "transcription elongation factor, mitochondrial", "refseq_ac": [ { "id": "NP_001020797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020797", "type": "external" } ], "gene_names_uniprotkb": "Tefm", "gene_names_refseq": "RGD1306595; Tefm", "protein_names_uniprotkb": "Transcription elongation factor, mitochondrial", "protein_names_refseq": "transcription elongation factor, mitochondrial", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency (Disease Ontology:DOID:0060286)", "pathway": " (rno:287554)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006392 transcription elongation by mitochondrial RNA polymerase;GO:0002082 regulation of oxidative phosphorylation;GO:1903109 positive regulation of mitochondrial transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KM51-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63046-1", "uniprot_id": [ { "id": "RUNX1_RAT", "url": "https://www.uniprot.org/uniprot/Q63046", "type": "external" } ], "mass": 48556.0, "length": 450, "protein_name": "Runt-related transcription factor 1", "gene_name": "Runx1", "organism": "Rat", "refseq_name": "runt-related transcription factor 1", "refseq_ac": [ { "id": "NP_059021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059021", "type": "external" } ], "gene_names_uniprotkb": "Runx1; Aml1; Cbfa2", "gene_names_refseq": "Aml1; CBF-alpha-2; Cbfa2; PEA2-alpha; PEBP2-alpha; Runx1", "protein_names_uniprotkb": "Runt-related transcription factor 1; Acute myeloid leukemia 1 protein; CBF-alpha-2; Core-binding factor subunit alpha-2; Oncogene AML-1; PEA2-alpha B; PEBP2-alpha B; Polyomavirus enhancer-binding protein 2 alpha B subunit", "protein_names_refseq": "PEA2-alpha B; PEBP2-alpha B; acute myeloid leukemia 1 protein; core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene); core-binding factor subunit alpha-2; oncogene AML-1; polyomavirus enhancer-binding protein 2 alpha B subunit; runt-related transcription factor 1", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); stomach cancer (Disease Ontology:DOID:10534); endometrial cancer (Disease Ontology:DOID:1380); endometriosis (Disease Ontology:DOID:289); colon signet ring adenocarcinoma (Disease Ontology:DOID:3033); middle cerebral artery infarction (Disease Ontology:DOID:3525); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:50662); (R-RNO-549127); (R-RNO-8877330); (R-RNO-8931987); (R-RNO-8934593); (R-RNO-8936459); (R-RNO-8939236); (R-RNO-8939243); (R-RNO-8939245); (R-RNO-8939246); (R-RNO-8939247); (R-RNO-9018519)", "pathway_count": 12, "publication_count": 8, "publication_id_list": "22673903;33785732;34348917;37201407;37936072;38040660;38267920;7969143", "class_list": "", "function": "Age-related promoter-switch regulates Runx1 expression in adult rat hearts. Publication Status: Online-Only, [RefSeq, PubMed]; CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (By similarity). Positively regulates the expression of RORC in T-helper 17 cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Endothelial progenitor cells-derived exosomal microRNA-21-5p alleviates sepsis-induced acute kidney injury by inhibiting RUNX1 expression. Publication Status: Online-Only, [RefSeq, PubMed]; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MiR-9 targeting RUNX1 improves LPS-induced alveolar hypercoagulation and fibrinolysis inhibition through NF-kappaB inactivation in ARDS., [RefSeq, PubMed]; RUNX1 targeting AKT3 promotes alveolar hypercoagulation and fibrinolytic inhibition in LPS induced ARDS. Publication Status: Online-Only, [RefSeq, PubMed]; Runx1 is upregulated by STAT3 and promotes proliferation of neonatal rat cardiomyocytes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0005604 basement membrane;GO:0016513 core-binding factor complex", "go_biological_process": "GO:0030854 positive regulation of granulocyte differentiation;GO:0002318 myeloid progenitor cell differentiation;GO:0002573 myeloid leukocyte differentiation;GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation;GO:0035162 embryonic hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q63046-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HC7-1", "uniprot_id": [ { "id": "SP20H_RAT", "url": "https://www.uniprot.org/uniprot/Q66HC7", "type": "external" } ], "mass": 59513.0, "length": 530, "protein_name": "Transcription factor SPT20 homolog", "gene_name": "Supt20h", "organism": "Rat", "refseq_name": "transcription factor SPT20 homolog isoform X25", "refseq_ac": [ { "id": "XP_063138167", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063138167", "type": "external" } ], "gene_names_uniprotkb": "Supt20h; Fam48a; Supt20", "gene_names_refseq": "Fam48a; RGD1307812; Supt20h; Supt20", "protein_names_uniprotkb": "Transcription factor SPT20 homolog", "protein_names_refseq": "transcription factor SPT20 homolog isoform X25", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0070461 SAGA-type complex;GO:0000124 SAGA complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007369 gastrulation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66HC7-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63945-1", "uniprot_id": [ { "id": "SET_RAT", "url": "https://www.uniprot.org/uniprot/Q63945", "type": "external" } ], "mass": 33406.0, "length": 289, "protein_name": "Protein SET", "gene_name": "Pkn3; Setl2; Setsip; Set", "organism": "Rat", "refseq_name": "protein SET", "refseq_ac": [ { "id": "NP_001012522", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012522", "type": "external" } ], "gene_names_uniprotkb": "Pkn3; Setl2; Setsip; Set; Ab1-115; SET; Set", "gene_names_refseq": "Ab1-115; Setsip; Set", "protein_names_uniprotkb": "Protein SET; I-2PP2A; Liver regeneration-related protein LRRGR00002; Phosphatase 2A inhibitor I2PP2A; TAF-I; Template-activating factor I", "protein_names_refseq": "I-2PP2A; SET nuclear oncogene; SET nuclear proto-oncogene; SET translocation; TAF-I; liver regeneration-related protein LRRGR00002; phosphatase 2A inhibitor I2PP2A; protein SET; template-activating factor I", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder 58 (Disease Ontology:DOID:0061032)", "pathway": " (rno:120101889); (rno:296619); (rno:307947); (R-RNO-2299718); (R-RNO-450520)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "11078917;20651003;23233674;7508204", "class_list": "", "function": "Contributes to invasiveness in malignant prostate cancer., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Induced expression of the C-terminal fragment (I(2CTF)) of I(2)(PP2A), also called SET, in rat brain, decrease in protein phosphatase 2A (PP2A) activity, abnormal hyperphosphorylation of tau, and neurodegeneration, [RefSeq, PubMed]; Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SET protein interacts with intracellular domains of the gonadotropin-releasing hormone receptor and differentially regulates receptor signaling to cAMP and calcium in gonadotrope cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPA3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0042393 histone binding;GO:0005524 ATP binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0043524 negative regulation of neuron apoptotic process;GO:0006334 nucleosome assembly;GO:0045446 endothelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63945-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T1H6-1", "uniprot_id": [ { "id": "UBE3D_RAT", "url": "https://www.uniprot.org/uniprot/Q3T1H6", "type": "external" } ], "mass": 41056.0, "length": 370, "protein_name": "E3 ubiquitin-protein ligase E3D", "gene_name": "Ube3d", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase E3D isoform 1", "refseq_ac": [ { "id": "NP_001034699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034699", "type": "external" } ], "gene_names_uniprotkb": "Ube3d; H10bh; Ube2cbp", "gene_names_refseq": "RGD1306773; Ube2cbp; Ube3d", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase E3D; 2.3.2.26; HECT-type E3 ubiquitin transferase E3D; UbcH10-binding protein with a HECT-like domain; Ubiquitin-conjugating enzyme E2C-binding protein", "protein_names_refseq": "E3 ubiquitin-protein ligase E3D isoform 1; E3 ubiquitin-protein ligase E3D; HECT-type E3 ubiquitin transferase E3D; UbcH10 binding protein with a hect-like domain; ubcH10-binding protein with a HECT-like domain; ubiquitin-conjugating enzyme E2C-binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:315863); (R-RNO-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0008428 ribonuclease inhibitor activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex;GO:0005874 microtubule", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0051865 protein autoubiquitination;GO:0006513 protein monoubiquitination;GO:0031110 regulation of microtubule polymerization or depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3T1H6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVQ9-1", "uniprot_id": [ { "id": "TBCE_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVQ9", "type": "external" } ], "mass": 59043.0, "length": 524, "protein_name": "Tubulin-specific chaperone E", "gene_name": "Tbce", "organism": "Rat", "refseq_name": "tubulin-specific chaperone E", "refseq_ac": [ { "id": "NP_001012161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012161", "type": "external" } ], "gene_names_uniprotkb": "Tbce", "gene_names_refseq": "Tbce", "protein_names_uniprotkb": "Tubulin-specific chaperone E; Tubulin-folding cofactor E", "protein_names_refseq": "tubulin-specific chaperone E", "tax_id": 10116, "disease": "hypoparathyroidism-retardation-dysmorphism syndrome (Disease Ontology:DOID:0060348); Kenny-Caffey syndrome type 1 (Disease Ontology:DOID:0080722); hypoparathyroidism (Disease Ontology:DOID:11199)", "pathway": " (rno:361255)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0048936 peripheral nervous system neuron axonogenesis;GO:0007409 axonogenesis;GO:0008344 adult locomotory behavior;GO:0009791 post-embryonic development;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVQ9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWT5-1", "uniprot_id": [ { "id": "S41A3_RAT", "url": "https://www.uniprot.org/uniprot/Q3SWT5", "type": "external" } ], "mass": 50526.0, "length": 462, "protein_name": "Solute carrier family 41 member 3", "gene_name": "Slc41a3", "organism": "Rat", "refseq_name": "solute carrier family 41 member 3 isoform 1", "refseq_ac": [ { "id": "NP_001032569", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032569", "type": "external" } ], "gene_names_uniprotkb": "Slc41a3", "gene_names_refseq": "Slc41a3", "protein_names_uniprotkb": "Solute carrier family 41 member 3", "protein_names_refseq": "solute carrier family 41 member 3 isoform 1", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:641603)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a magnesium transporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the mitochondrial inner membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061768 magnesium:sodium antiporter activity;GO:0008324 monoatomic cation transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0045016 mitochondrial magnesium ion transmembrane transport;GO:0015693 magnesium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SWT5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8G0-1", "uniprot_id": [ { "id": "LRC63_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8G0", "type": "external" } ], "mass": 69217.0, "length": 607, "protein_name": "Leucine-rich repeat-containing protein 63", "gene_name": "Lrrc63", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 63", "refseq_ac": [ { "id": "NP_001019974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019974", "type": "external" } ], "gene_names_uniprotkb": "Lrrc63", "gene_names_refseq": "Lrrc63", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 63", "protein_names_refseq": "leucine-rich repeat-containing protein 63", "tax_id": 10116, "disease": "", "pathway": " (rno:364427)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8G0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68G12-1", "uniprot_id": [ { "id": "SIAT9_RAT", "url": "https://www.uniprot.org/uniprot/Q68G12", "type": "external" } ], "mass": 44640.0, "length": 387, "protein_name": "Lactosylceramide alpha-2,3-sialyltransferase", "gene_name": "St3gal5", "organism": "Rat", "refseq_name": "lactosylceramide alpha-2,3-sialyltransferase isoform 2", "refseq_ac": [ { "id": "NP_112627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112627", "type": "external" } ], "gene_names_uniprotkb": "St3gal5; Siat9", "gene_names_refseq": "Siat9; St3gal5", "protein_names_uniprotkb": "Lactosylceramide alpha-2,3-sialyltransferase; 2.4.3.9; CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; Ganglioside GM3 synthase; ST3Gal V; ST3GalV; Sialyltransferase 9", "protein_names_refseq": "CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase); GM3 synthase; ST3Gal V; ST3GalV; ganglioside GM3 synthase; lactosylceramide alpha-2,3-sialyltransferase isoform 2; lactosylceramide alpha-2,3-sialyltransferase; sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase); sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase", "tax_id": 10116, "disease": "salt and pepper syndrome (Disease Ontology:DOID:0060470)", "pathway": " (rno:83505); (R-RNO-4085001); (R-RNO-9840309)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "38843836", "class_list": "glycogene;glycosyltransferase", "function": "Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer (LacCer)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O88830", "ec_number_list": [ { "id": "2.4.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.2", "type": "external" }, { "id": "2.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.4", "type": "external" }, { "id": "3.6.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.59", "type": "external" }, { "id": "2.4.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.6", "type": "external" }, { "id": "2.4.3.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.9", "type": "external" } ], "go_molecular_function": "GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 412, "hit_score": 0.4, "record_id": "Q68G12-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIH2-1", "uniprot_id": [ { "id": "SHSA5_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIH2", "type": "external" } ], "mass": 13881.0, "length": 130, "protein_name": "Protein shisa-5", "gene_name": "Shisa5", "organism": "Rat", "refseq_name": "protein shisa-5 isoform 4", "refseq_ac": [ { "id": "NP_001006990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006990", "type": "external" } ], "gene_names_uniprotkb": "Shisa5; Scotin", "gene_names_refseq": "Shisa5", "protein_names_uniprotkb": "Protein shisa-5; Scotin", "protein_names_refseq": "protein shisa-5 isoform 4; protein shisa-5; scotin; shisa homolog 5", "tax_id": 10116, "disease": "", "pathway": " (rno:301013)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050699 WW domain binding;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0060628 regulation of ER to Golgi vesicle-mediated transport;GO:1905898 positive regulation of response to endoplasmic reticulum stress;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator;GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIH2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI05-1", "uniprot_id": [ { "id": "SE1L2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI05", "type": "external" } ], "mass": 77831.0, "length": 688, "protein_name": "Protein sel-1 homolog 2", "gene_name": "Sel1l2", "organism": "Rat", "refseq_name": "protein sel-1 homolog 2 precursor", "refseq_ac": [ { "id": "NP_001014071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014071", "type": "external" } ], "gene_names_uniprotkb": "Sel1l2", "gene_names_refseq": "RGD1311278; Sel1l2", "protein_names_uniprotkb": "Protein sel-1 homolog 2; Sel-1L2; Suppressor of lin-12-like protein 2", "protein_names_refseq": "SEL1L2 ERAD E3 ligase adaptor subunit; SEL1L2 adaptor subunit of ERAD E3 ligase; SEL1L2 adaptor subunit of ERAD E3 ubiquitin ligase; protein sel-1 homolog 2 precursor; protein sel-1 homolog 2; sel-1 suppressor of lin-12-like 2; sel-1L2; suppressor of lin-12-like protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:311470)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0016607 nuclear speck;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI05-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01992-1", "uniprot_id": [ { "id": "MIPEP_RAT", "url": "https://www.uniprot.org/uniprot/Q01992", "type": "external" } ], "mass": 80674.0, "length": 710, "protein_name": "Mitochondrial intermediate peptidase", "gene_name": "Mipep", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mipep; Mip", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial intermediate peptidase; 3.4.24.59; MIP", "protein_names_refseq": "", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency 31 (Disease Ontology:DOID:0111488); lipodystrophy (Disease Ontology:DOID:811)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1322290;1518864", "class_list": "", "function": "Cleaves proteins, imported into the mitochondrion, to their mature size., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006627 protein processing involved in protein targeting to mitochondrion;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q01992-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KR73-1", "uniprot_id": [ { "id": "KANL3_RAT", "url": "https://www.uniprot.org/uniprot/Q3KR73", "type": "external" } ], "mass": 93035.0, "length": 877, "protein_name": "KAT8 regulatory NSL complex subunit 3", "gene_name": "Kansl3", "organism": "Rat", "refseq_name": "KAT8 regulatory NSL complex subunit 3", "refseq_ac": [ { "id": "NP_001030007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030007", "type": "external" } ], "gene_names_uniprotkb": "Kansl3; Nsl3", "gene_names_refseq": "Kansl3; RGD1309220", "protein_names_uniprotkb": "KAT8 regulatory NSL complex subunit 3; NSL complex protein NSL3; Non-specific lethal 3 homolog", "protein_names_refseq": "KAT8 regulatory NSL complex subunit 3; NSL complex protein NSL3; non-specific lethal 3 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:316328); (R-RNO-3214847); (R-RNO-9772755)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. The NSL complex also acts as a regulator of gene expression in mitochondria. Within the NSL complex, KANSL3 is required to promote KAT8 association with mitochondrial DNA. Required for transcription of intraciliary transport genes in both ciliated and non-ciliated cells. This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Also required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA. Plays an essential role in spindle assembly during mitosis. Acts as a microtubule minus-end binding protein which stabilizes microtubules and promotes their assembly. Indispensable during early embryonic development where it is required for proper lineage specification and maintenance during peri-implantation development and is essential for implantation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005874 microtubule;GO:0000123 histone acetyltransferase complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:1903108 regulation of mitochondrial transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3KR73-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQN6-1", "uniprot_id": [ { "id": "SPE39_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQN6", "type": "external" } ], "mass": 53305.0, "length": 460, "protein_name": "Spermatogenesis-defective protein 39 homolog", "gene_name": "Vipas39", "organism": "Rat", "refseq_name": "spermatogenesis-defective protein 39 homolog isoform 2", "refseq_ac": [ { "id": "NP_001094474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094474", "type": "external" } ], "gene_names_uniprotkb": "Vipas39; Spe39; Vipar", "gene_names_refseq": "Spe39; Vipar; Vipas39; hSPE-39", "protein_names_uniprotkb": "Spermatogenesis-defective protein 39 homolog; VPS33B-interacting protein in apical-basolateral polarity regulator; VPS33B-interacting protein in polarity and apical restriction; hSPE-39", "protein_names_refseq": "VPS33B-interacting protein in apical-basolateral polarity regulator; VPS33B-interacting protein in polarity and apical restriction; protein spe-39 homolog; spermatogenesis-defective protein 39 homolog isoform 2; spermatogenesis-defective protein 39 homolog", "tax_id": 10116, "disease": "ARC syndrome (Disease Ontology:DOID:0050763); arthrogryposis, renal dysfunction, and cholestasis 2 (Disease Ontology:DOID:0111354)", "pathway": " (rno:681989)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;22677173", "class_list": "", "function": "Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B. May play a role in vesicular trafficking during spermatogenesis. May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0055037 recycling endosome", "go_biological_process": "GO:0007034 vacuolar transport;GO:0006351 DNA-templated transcription;GO:0006886 intracellular protein transport;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5PQN6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4G009-1", "uniprot_id": [ { "id": "MCTS1_RAT", "url": "https://www.uniprot.org/uniprot/Q4G009", "type": "external" } ], "mass": 20550.0, "length": 182, "protein_name": "Malignant T-cell-amplified sequence 1", "gene_name": "Mcts1", "organism": "Rat", "refseq_name": "malignant T-cell-amplified sequence 1 isoform 2", "refseq_ac": [ { "id": "NP_001037702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037702", "type": "external" } ], "gene_names_uniprotkb": "Mcts1", "gene_names_refseq": "Mcts1", "protein_names_uniprotkb": "Malignant T-cell-amplified sequence 1; MCT-1", "protein_names_refseq": "MCT-1; malignant T-cell-amplified sequence 1 isoform 2; malignant T-cell-amplified sequence 1", "tax_id": 10116, "disease": "immunodeficiency 118 (Disease Ontology:DOID:0061084)", "pathway": " (rno:302500)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32160403", "class_list": "", "function": "Maresin Conjugates in Tissue Regeneration 1 improves alveolar fluid clearance by up-regulating alveolar ENaC, Na, K-ATPase in lipopolysaccharide-induced acute lung injury., [RefSeq, PubMed]; Translation regulator forming a complex with DENR to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent. Consequently, modulates various unrelated biological processes including cell cycle regulation and DNA damage signaling and repair. Notably, it positively regulates interferon gamma immunity to mycobacteria by enhancing the translation of JAK2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043024 ribosomal small subunit binding;GO:0003743 translation initiation factor activity;GO:0000339 RNA cap binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002188 translation reinitiation;GO:0032790 ribosome disassembly;GO:0075522 IRES-dependent viral translational initiation;GO:0006351 DNA-templated transcription;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4G009-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWT1-1", "uniprot_id": [ { "id": "SOSB1_RAT", "url": "https://www.uniprot.org/uniprot/Q3SWT1", "type": "external" } ], "mass": 22377.0, "length": 211, "protein_name": "SOSS complex subunit B1", "gene_name": "Nabp2", "organism": "Rat", "refseq_name": "SOSS complex subunit B1 isoform 1", "refseq_ac": [ { "id": "NP_001030111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030111", "type": "external" } ], "gene_names_uniprotkb": "Nabp2; Obfc2b; Ssb1", "gene_names_refseq": "Nabp2; Obfc2b; RGD1308158", "protein_names_uniprotkb": "SOSS complex subunit B1; Nucleic acid-binding protein 2; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; SOSS-B1; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; Single-stranded DNA-binding protein 1", "protein_names_refseq": "SOSS complex subunit B1 isoform 1; SOSS complex subunit B1; SOSS-B1; oligonucleotide/oligosaccharide-binding fold containing 2B; oligonucleotide/oligosaccharide-binding fold-containing protein 2B; sensor of single-strand DNA complex subunit B1; sensor of ssDNA subunit B1; single-stranded DNA-binding protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:362813); (R-RNO-6807505)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0098505 G-rich strand telomeric DNA binding;GO:0003677 DNA binding;GO:0070182 DNA polymerase binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break;GO:0000781 chromosome, telomeric region;GO:0070876 SOSS complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0070200 establishment of protein localization to telomere;GO:0010212 response to ionizing radiation;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3SWT1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62807-1", "uniprot_id": [ { "id": "SYT17_RAT", "url": "https://www.uniprot.org/uniprot/Q62807", "type": "external" } ], "mass": 53827.0, "length": 474, "protein_name": "Synaptotagmin-17", "gene_name": "Syt17", "organism": "Rat", "refseq_name": "synaptotagmin-17", "refseq_ac": [ { "id": "NP_620204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620204", "type": "external" } ], "gene_names_uniprotkb": "Syt17; Bk", "gene_names_refseq": "Bk; Syt17", "protein_names_uniprotkb": "Synaptotagmin-17; Protein B/K; Synaptotagmin XVII; SytXVII", "protein_names_refseq": "B/K protein; brain and kidney protein; protein B/K; synaptotagmin XVII; synaptotagmin-17; sytXVII", "tax_id": 10116, "disease": "", "pathway": " (rno:192189)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14759499;16896191;22673903;8549819", "class_list": "", "function": "B/K protein is closely associated with cell death in proximal tubules, which are vulnerable to ischemia-reperfusion injury in the kidney, [RefSeq, PubMed]; Induction of both B/K protein expression and ER stress response in hippocampus of a rat kainate seizure model and ER stress-induced expression of B/K strongly suggest the possible role of B/K protein in epileptogenesis or epilepsy-induced neuronal damage, [RefSeq, PubMed]; Plays a role in dendrite formation by melanocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005544 calcium-dependent phospholipid binding;GO:0000149 SNARE binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0098794 postsynapse;GO:0005802 trans-Golgi network;GO:0070382 exocytic vesicle", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0030154 cell differentiation;GO:0016192 vesicle-mediated transport;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62807-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EBA1-1", "uniprot_id": [ { "id": "SUV3_RAT", "url": "https://www.uniprot.org/uniprot/Q5EBA1", "type": "external" } ], "mass": 86706.0, "length": 776, "protein_name": "ATP-dependent RNA helicase SUPV3L1, mitochondrial", "gene_name": "Supv3l1", "organism": "Rat", "refseq_name": "ATP-dependent RNA helicase SUPV3L1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001012480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012480", "type": "external" } ], "gene_names_uniprotkb": "Supv3l1", "gene_names_refseq": "Supv3l1", "protein_names_uniprotkb": "ATP-dependent RNA helicase SUPV3L1, mitochondrial; 3.6.4.13; SUV3-like protein 1; Suppressor of var1 3-like protein 1", "protein_names_refseq": "ATP-dependent RNA helicase SUPV3L1, mitochondrial precursor; ATP-dependent RNA helicase SUPV3L1, mitochondrial; SUV3-like helicase; SUV3-like protein 1; suppressor of var1 3-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:294385)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:0045025 mitochondrial degradosome", "go_biological_process": "GO:0006310 DNA recombination;GO:0030307 positive regulation of cell growth;GO:0043066 negative regulation of apoptotic process;GO:0007005 mitochondrion organization;GO:0000957 mitochondrial RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5EBA1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05511-1", "uniprot_id": [ { "id": "HEPS_RAT", "url": "https://www.uniprot.org/uniprot/Q05511", "type": "external" } ], "mass": 44926.0, "length": 416, "protein_name": "Serine protease hepsin", "gene_name": "Hpn", "organism": "Rat", "refseq_name": "serine protease hepsin precursor", "refseq_ac": [ { "id": "NP_058808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058808", "type": "external" } ], "gene_names_uniprotkb": "Hpn", "gene_names_refseq": "Hpn", "protein_names_uniprotkb": "Serine protease hepsin; 3.4.21.106", "protein_names_refseq": "hepsin (transmembrane protease, serine 1); serine protease hepsin precursor; serine protease hepsin", "tax_id": 10116, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (rno:29135); (R-RNO-6806942); (R-RNO-8852405)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "17918732;21734266;8318546", "class_list": "", "function": "Results suggest that hepsin and PDIA3 undergo proteolysis by MMP2/9 in ovarian granulosa cells during ovulation and/or luteinization., [RefSeq, PubMed]; Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL. Plays a role in cell growth and maintenance of cell morphology. Plays a role in the proteolytic processing of ACE2. Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.106", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0008236 serine-type peptidase activity;GO:0070008 serine-type exopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:0060429 epithelium development;GO:0010756 positive regulation of plasminogen activation;GO:0006508 proteolysis;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q05511-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QR99-1", "uniprot_id": [ { "id": "TGT_RAT", "url": "https://www.uniprot.org/uniprot/Q4QR99", "type": "external" } ], "mass": 44187.0, "length": 403, "protein_name": "Queuine tRNA-ribosyltransferase catalytic subunit 1", "gene_name": "Qtrt1", "organism": "Rat", "refseq_name": "queuine tRNA-ribosyltransferase catalytic subunit 1", "refseq_ac": [ { "id": "NP_071586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071586", "type": "external" } ], "gene_names_uniprotkb": "Qtrt1; QTRT1", "gene_names_refseq": "Qtrt1; Tgt; Tgut", "protein_names_uniprotkb": "Queuine tRNA-ribosyltransferase catalytic subunit 1; 2.4.2.64; Guanine insertion enzyme; tRNA-guanine transglycosylase", "protein_names_refseq": "guanine insertion enzyme; queuine tRNA-ribosyltransferase 1; queuine tRNA-ribosyltransferase catalytic subunit 1; tRNA-guanine transglycosylase", "tax_id": 10116, "disease": "", "pathway": " (rno:64016)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26446791;6986171", "class_list": "", "function": "Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product., [UniProtKB, HAMAP, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JMA0", "ec_number_list": [ { "id": "2.4.2.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.64", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity", "go_cellular_component": "GO:1990234 transferase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0032991 protein-containing complex", "go_biological_process": "GO:0008616 tRNA queuosine(34) biosynthetic process;GO:0002099 tRNA wobble guanine modification", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4QR99-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FR3-1", "uniprot_id": [ { "id": "INT12_RAT", "url": "https://www.uniprot.org/uniprot/Q68FR3", "type": "external" } ], "mass": 48477.0, "length": 461, "protein_name": "Integrator complex subunit 12", "gene_name": "Ints12", "organism": "Rat", "refseq_name": "integrator complex subunit 12", "refseq_ac": [ { "id": "NP_001007641", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007641", "type": "external" } ], "gene_names_uniprotkb": "Ints12; Phf22", "gene_names_refseq": "Ints12; Phf22", "protein_names_uniprotkb": "Integrator complex subunit 12; Int12; PHD finger protein 22", "protein_names_refseq": "PHD finger protein 22; int12; integrator complex subunit 12", "tax_id": 10116, "disease": "", "pathway": " (rno:295448); (R-RNO-6807505)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0032039 integrator complex;GO:0160232 INTAC complex", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0016180 snRNA processing;GO:0034472 snRNA 3'-end processing;GO:0160240 RNA polymerase II transcription initiation surveillance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68FR3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJ95-1", "uniprot_id": [ { "id": "IL17F_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJ95", "type": "external" } ], "mass": 17712.0, "length": 161, "protein_name": "Interleukin-17F", "gene_name": "Il17f", "organism": "Rat", "refseq_name": "interleukin-17F precursor", "refseq_ac": [ { "id": "NP_001015011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015011", "type": "external" } ], "gene_names_uniprotkb": "Il17f", "gene_names_refseq": "IL-17F; Il17f", "protein_names_uniprotkb": "Interleukin-17F; IL-17F", "protein_names_refseq": "interleukin-17F precursor", "tax_id": 10116, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); leprosy (Disease Ontology:DOID:1024); pneumoconiosis (Disease Ontology:DOID:10316); silicosis (Disease Ontology:DOID:10325); diffuse scleroderma (Disease Ontology:DOID:1580); chronic mucocutaneous candidiasis (Disease Ontology:DOID:2058); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); allergic rhinitis (Disease Ontology:DOID:4481); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (rno:301291)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation. As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers. IL17F homodimer can signal via IL17RC homodimeric receptor complex, triggering downstream activation of TRAF6 and NF-kappa-B signaling pathway. Via IL17RC induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi. Likely via IL17RC, promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression. Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005125 cytokine activity;GO:0019955 cytokine binding;GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJ95-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJN4-1", "uniprot_id": [ { "id": "SHFL_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJN4", "type": "external" } ], "mass": 18865.0, "length": 163, "protein_name": "Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog", "gene_name": "Shfl", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Shfl; LOC500956; Ryden", "gene_names_refseq": "", "protein_names_uniprotkb": "Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog; Repressor of yield of DENV protein homolog; RyDEN; SHFL", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses and cellular genes. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site. May exhibit antiviral activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body", "go_biological_process": "GO:0006449 regulation of translational termination;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0034341 response to type II interferon;GO:0035456 response to interferon-beta", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RJN4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97708-1", "uniprot_id": [ { "id": "ZP3_RAT", "url": "https://www.uniprot.org/uniprot/P97708", "type": "external" } ], "mass": 45901.0, "length": 424, "protein_name": "Zona pellucida sperm-binding protein 3", "gene_name": "Zp3", "organism": "Rat", "refseq_name": "zona pellucida sperm-binding protein 3 precursor", "refseq_ac": [ { "id": "NP_446214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446214", "type": "external" } ], "gene_names_uniprotkb": "Zp3; Zp-3; Zpc", "gene_names_refseq": "Zp-3; Zp3", "protein_names_uniprotkb": "Zona pellucida sperm-binding protein 3; Zona pellucida glycoprotein 3; Zona pellucida protein C; Zp-3", "protein_names_refseq": "zona pellucida glycoprotein 3 (sperm receptor); zona pellucida glycoprotein ZP3; zona pellucida protein C; zona pellucida sperm-binding protein 3 precursor; zona pellucida sperm-binding protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:114639)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16342937;33624742;9820205", "class_list": "", "function": "Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the zona pellucida, resulting in zona absence and female infertility in ratsdagger., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 1, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "O55084", "ec_number_list": [], "go_molecular_function": "GO:0035804 structural constituent of egg coat;GO:0032190 acrosin binding;GO:0042802 identical protein binding;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0035805 egg coat", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:2000386 positive regulation of ovarian follicle development;GO:0035803 egg coat formation;GO:0007339 binding of sperm to zona pellucida;GO:0002455 humoral immune response mediated by circulating immunoglobulin", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P97708-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54275-1", "uniprot_id": [ { "id": "MSH2_RAT", "url": "https://www.uniprot.org/uniprot/P54275", "type": "external" } ], "mass": 104028.0, "length": 933, "protein_name": "DNA mismatch repair protein Msh2", "gene_name": "Msh2", "organism": "Rat", "refseq_name": "DNA mismatch repair protein Msh2", "refseq_ac": [ { "id": "NP_112320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112320", "type": "external" } ], "gene_names_uniprotkb": "Msh2", "gene_names_refseq": "Msh2", "protein_names_uniprotkb": "DNA mismatch repair protein Msh2; MutS protein homolog 2", "protein_names_refseq": "DNA mismatch repair protein Msh2; mismatch repair protein; mutS protein homolog 2", "tax_id": 10116, "disease": "Muir-Torre syndrome (Disease Ontology:DOID:0050465); colitis (Disease Ontology:DOID:0060180); hereditary nonpolyposis colorectal cancer type 8 (Disease Ontology:DOID:0070270); Lynch syndrome 1 (Disease Ontology:DOID:0070271); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); colon cancer (Disease Ontology:DOID:219); transitional cell carcinoma (Disease Ontology:DOID:2671); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); osteosarcoma (Disease Ontology:DOID:3347); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Lynch syndrome (Disease Ontology:DOID:3883); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); primary ovarian insufficiency (Disease Ontology:DOID:5426); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:81709); (R-RNO-5358565)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "35741815;9034308", "class_list": "", "function": "Component of the post-replicative DNA mismatch repair system (MMR)., [UniProtKB, UniProtKB, UniProtKB]; Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis., [UniProtKB, UniProtKB]; Potential Influence of Age and Diabetes Mellitus Type 1 on MSH2 (MutS homolog 2) Expression in a Rat Kidney Tissue. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0008047 enzyme activator activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0032301 MutSalpha complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005694 chromosome;GO:0032302 MutSbeta complex", "go_biological_process": "GO:0006312 mitotic recombination;GO:0001701 in utero embryonic development;GO:0006281 DNA repair;GO:0007283 spermatogenesis;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P54275-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62784-1", "uniprot_id": [ { "id": "INP4A_RAT", "url": "https://www.uniprot.org/uniprot/Q62784", "type": "external" } ], "mass": 105589.0, "length": 939, "protein_name": "Inositol polyphosphate-4-phosphatase type I A", "gene_name": "Inpp4a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Inpp4a", "gene_names_refseq": "", "protein_names_uniprotkb": "Inositol polyphosphate-4-phosphatase type I A; 3.1.3.66; Inositol polyphosphate 4-phosphatase type I; Type I inositol 3,4-bisphosphate 4-phosphatase", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:80849); (R-RNO-1660499); (R-RNO-1660516); (R-RNO-1855183)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "17496889;22673903;7608176", "class_list": "", "function": "Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PubMed:7608176). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (PubMed:7608176). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity)., [UniProtKB, PubMed, UniProtKB]; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate. Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.66", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.66", "type": "external" } ], "go_molecular_function": "GO:0017161 inositol-1,3,4-trisphosphate 4-phosphatase activity;GO:0052828 inositol-3,4-bisphosphate 4-phosphatase activity;GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0044281 small molecule metabolic process;GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q62784-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63416-1", "uniprot_id": [ { "id": "ITIH3_RAT", "url": "https://www.uniprot.org/uniprot/Q63416", "type": "external" } ], "mass": 99098.0, "length": 887, "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H3", "gene_name": "Itih3", "organism": "Rat", "refseq_name": "inter-alpha-trypsin inhibitor heavy chain H3 precursor", "refseq_ac": [ { "id": "NP_059047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059047", "type": "external" } ], "gene_names_uniprotkb": "Itih3", "gene_names_refseq": "Itih3; PAIHC3", "protein_names_uniprotkb": "Inter-alpha-trypsin inhibitor heavy chain H3; ITI heavy chain H3; ITI-HC3; Inter-alpha-inhibitor heavy chain 3", "protein_names_refseq": "ITI heavy chain H3; ITI-HC3; inter-alpha-inhibitor heavy chain 3; inter-alpha-trypsin inhibitor heavy chain H3 precursor; inter-alpha-trypsin inhibitor heavy chain H3; pre-alpha-inhibitor, heavy chain 3", "tax_id": 10116, "disease": "", "pathway": " (rno:50693); (R-RNO-114608)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11827976;21454685", "class_list": "", "function": "Intracellular coupling of the heavy chain of pre-alpha-inhibitor to chondroitin sulfate, [RefSeq, PubMed]; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0030212 hyaluronan metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63416-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZQU0-1", "uniprot_id": [ { "id": "SNED1_RAT", "url": "https://www.uniprot.org/uniprot/Q5ZQU0", "type": "external" } ], "mass": 151401.0, "length": 1403, "protein_name": "Sushi, nidogen and EGF-like domain-containing protein 1", "gene_name": "Sned1", "organism": "Rat", "refseq_name": "sushi, nidogen and EGF-like domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_001400770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001400770", "type": "external" } ], "gene_names_uniprotkb": "Sned1", "gene_names_refseq": "IRE-BP1; Sned1", "protein_names_uniprotkb": "Sushi, nidogen and EGF-like domain-containing protein 1; IRE-BP1; Insulin-responsive sequence DNA-binding protein 1", "protein_names_refseq": "insulin-responsive sequence DNA-binding protein 1; sushi, nidogen and EGF-like domain-containing protein 1 precursor; sushi, nidogen and EGF-like domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:316638)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15194686;15753094;18566119;19213832", "class_list": "", "function": "Identified a novel transcription factor,insulin-response element-binding protein 1, that binds and transactivates the insulin-response elements of the insulin-like growth factor-binding protein-3 and other insulin responsive genes, [RefSeq, PubMed]; Increased gene transcription mediated through IRE-BP1 may contribute to beta-cell dysfunction in insulin resistance, and allow for the hypothesis that IRE-BP1 plays a role in the pathophysiology of type 2 diabetes., [RefSeq, PubMed]; Stable constitutive expression of IRE-BP1 enhanced glucose transporter expression, glucose uptake, and glycogen accumulation, [RefSeq, PubMed]; Study supports the notion that IRE-BP1 may be relevant to the action of insulin in vivo and may play a role in the development of insulin resistance and diabetes, [RefSeq, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 11, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q336F3", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5ZQU0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06226-1", "uniprot_id": [ { "id": "SGK1_RAT", "url": "https://www.uniprot.org/uniprot/Q06226", "type": "external" } ], "mass": 48927.0, "length": 430, "protein_name": "Serine/threonine-protein kinase Sgk1", "gene_name": "Sgk1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sgk1; Sgk", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase Sgk1; 2.7.11.1; Serum/glucocorticoid-regulated kinase 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425); hypertension (Disease Ontology:DOID:10763); transient cerebral ischemia (Disease Ontology:DOID:224); granulosa cell tumor (Disease Ontology:DOID:2999); serous cystadenocarcinoma (Disease Ontology:DOID:3114); mucinous cystadenocarcinoma (Disease Ontology:DOID:3603)", "pathway": " (rno:29517); (R-RNO-1257604); (R-RNO-2672351); (R-RNO-6804757); (R-RNO-9031628)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10051674;10357815;15504348;16006511;16982696;19447520;7740159;7854047;8455596;8647846", "class_list": "", "function": "Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis (By similarity). Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. May also play an important role in the development of particular groups of neurons in the postnatal brain., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0015459 potassium channel regulator activity;GO:0048156 tau protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0008542 visual learning;GO:0030307 positive regulation of cell growth;GO:0032869 cellular response to insulin stimulus;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q06226-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83829-1", "uniprot_id": [ { "id": "IFT81_RAT", "url": "https://www.uniprot.org/uniprot/P83829", "type": "external" } ], "mass": 79029.0, "length": 675, "protein_name": "Intraflagellar transport protein 81 homolog", "gene_name": "Ift81", "organism": "Rat", "refseq_name": "intraflagellar transport protein 81 homolog", "refseq_ac": [ { "id": "NP_954551", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954551", "type": "external" } ], "gene_names_uniprotkb": "Ift81; Cdv1", "gene_names_refseq": "Cdv-1; Cdv1; Ift81", "protein_names_uniprotkb": "Intraflagellar transport protein 81 homolog; CDV-1; Carnitine deficiency-associated protein expressed in ventricle 1", "protein_names_refseq": "carnitine deficiency-associated gene expressed in ventricle 1; carnitine deficiency-associated protein expressed in ventricle 1; intraflagellar transport 81 homolog; intraflagellar transport protein 81 homolog", "tax_id": 10116, "disease": "short-rib thoracic dysplasia 19 with or without polydactyly (Disease Ontology:DOID:0080295)", "pathway": " (rno:373066); (R-RNO-5620924)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling (By similarity). Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005929 cilium;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007283 spermatogenesis;GO:0060271 cilium assembly;GO:0008589 regulation of smoothened signaling pathway;GO:0035735 intraciliary transport involved in cilium assembly;GO:0042073 intraciliary transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P83829-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02734-1", "uniprot_id": [ { "id": "SIAT6_RAT", "url": "https://www.uniprot.org/uniprot/Q02734", "type": "external" } ], "mass": 42082.0, "length": 374, "protein_name": "CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase", "gene_name": "St3gal3", "organism": "Rat", "refseq_name": "CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform 1", "refseq_ac": [ { "id": "NP_113885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113885", "type": "external" } ], "gene_names_uniprotkb": "St3gal3; Siat6", "gene_names_refseq": "ST3Gal III; ST3GalIII; ST3N; Siat6; St3gal3", "protein_names_uniprotkb": "CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase; 2.4.3.6; Alpha 2,3-ST 3; Beta-galactoside alpha-2,3-sialyltransferase 3; Gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase; N-acetyllactosaminide alpha-2,3-sialyltransferase; ST3Gal III; ST3GalIII; ST3N; Sialyltransferase 6", "protein_names_refseq": "CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform 1; CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase; N-acetyllacosaminide alpha 2,3-sialyltransferase; N-acetyllactosaminide alpha-2,3-sialyltransferase; beta-galactoside alpha-2,3-sialyltransferase 3; gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase; sialyltransferase (N-acetyllacosaminide alpha 23-sialyltransferase); sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase); sialyltransferase 6(N-acetyllacosaminide alpha 23-sialyltransferase)", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 15 (Disease Ontology:DOID:0080414); autosomal recessive intellectual developmental disorder 12 (Disease Ontology:DOID:0081180)", "pathway": " (rno:64445); (R-RNO-2022854); (R-RNO-4085001); (R-RNO-9037629); (R-RNO-977068); (R-RNO-9840309)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "1400416;20824144", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; St3gal3 modulates pancreatic cancer cell motility and adhesion and enhances metastatic potential. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.2", "type": "external" }, { "id": "2.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.4", "type": "external" }, { "id": "3.6.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.59", "type": "external" }, { "id": "2.4.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.6", "type": "external" }, { "id": "2.4.3.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.9", "type": "external" } ], "go_molecular_function": "GO:0008373 sialyltransferase activity;GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity;GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0001574 ganglioside biosynthetic process", "synthesized_glycan_count": 2417, "hit_score": 0.3, "record_id": "Q02734-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVL7-1", "uniprot_id": [ { "id": "KTU_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVL7", "type": "external" } ], "mass": 89349.0, "length": 817, "protein_name": "Protein kintoun", "gene_name": "Dnaaf2", "organism": "Rat", "refseq_name": "protein kintoun", "refseq_ac": [ { "id": "NP_001014219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014219", "type": "external" } ], "gene_names_uniprotkb": "Dnaaf2; DNAAF2; KTU; Ktu", "gene_names_refseq": "Dnaaf2; Ktu; RGD1310311", "protein_names_uniprotkb": "Protein kintoun; Dynein assembly factor 2, axonemal", "protein_names_refseq": "dynein assembly factor 2, axonemal; protein kintoun", "tax_id": 10116, "disease": "primary ciliary dyskinesia 10 (Disease Ontology:DOID:0110612)", "pathway": " (rno:362746)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0101031 protein folding chaperone complex;GO:0120293 dynein axonemal particle", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0032526 response to retinoic acid;GO:0036158 outer dynein arm assembly;GO:0036159 inner dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FVL7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q499M7-1", "uniprot_id": [ { "id": "LRIF1_RAT", "url": "https://www.uniprot.org/uniprot/Q499M7", "type": "external" } ], "mass": 82669.0, "length": 748, "protein_name": "Ligand-dependent nuclear receptor-interacting factor 1", "gene_name": "Lrif1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lrif1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ligand-dependent nuclear receptor-interacting factor 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "facioscapulohumeral muscular dystrophy 3 (Disease Ontology:DOID:0060917)", "pathway": " (rno:310775)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin. Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042974 nuclear retinoic acid receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016363 nuclear matrix;GO:0000781 chromosome, telomeric region;GO:0001740 Barr body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0009048 dosage compensation by inactivation of X chromosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q499M7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62674-1", "uniprot_id": [ { "id": "S28A1_RAT", "url": "https://www.uniprot.org/uniprot/Q62674", "type": "external" } ], "mass": 71001.0, "length": 648, "protein_name": "Sodium/nucleoside cotransporter 1", "gene_name": "Slc28a1", "organism": "Rat", "refseq_name": "sodium/nucleoside cotransporter 1", "refseq_ac": [ { "id": "NP_446315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446315", "type": "external" } ], "gene_names_uniprotkb": "Slc28a1; Cnt1", "gene_names_refseq": "Cnt1; Slc28a1", "protein_names_uniprotkb": "Sodium/nucleoside cotransporter 1; CNT 1; Concentrative nucleoside transporter 1; Na(+)/nucleoside cotransporter 1; Sodium-coupled nucleoside transporter 1; Solute carrier family 28 member 1", "protein_names_refseq": "CNT 1; Na(+)/nucleoside cotransporter 1; concentrative nucleoside transporter 1; sodium-coupled nucleoside transporter 1; sodium/nucleoside cotransporter 1; solute carrier family 28 (concentrative nucleoside transporter), member 1; solute carrier family 28 (sodium-coupled nucleoside transporter), member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:116642); (R-RNO-83936)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11375981;12176019;16014043;8027026;8967974", "class_list": "", "function": "Cell-cycle-dependent regulation of CNT1 protein levels in a rat hepatoma cell line., [RefSeq, PubMed]; Diabetes increased CNT1 and CNT3 expression in the glomerulus and insulin treatment decreased it, [RefSeq, PubMed]; Sodium and pyrimidine nucleoside symporter of the plasma membrane that imports uridine, thymidine and cytidine into cells by coupling their transport to the transmembrane sodium electrochemical gradient. Also transports adenosine, an atypical substrate transported with high apparent affinity, but low maximum velocity. Therefore, exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (PubMed:8027026, PubMed:8967974). Involved in renal nucleoside (re)absorption (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015213 uridine transmembrane transporter activity;GO:0005350 pyrimidine nucleobase transmembrane transporter activity;GO:0015389 pyrimidine- and adenosine-specific:sodium symporter activity;GO:1901474 azole transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0015861 cytidine transport;GO:0015862 uridine transmembrane transport;GO:0015855 pyrimidine nucleobase transport;GO:1901642 nucleoside transmembrane transport;GO:0072531 pyrimidine-containing compound transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62674-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000100000000.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63505-1", "uniprot_id": [ { "id": "TF3C1_RAT", "url": "https://www.uniprot.org/uniprot/Q63505", "type": "external" } ], "mass": 242306.0, "length": 2148, "protein_name": "General transcription factor 3C polypeptide 1", "gene_name": "Gtf3c1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gtf3c1", "gene_names_refseq": "", "protein_names_uniprotkb": "General transcription factor 3C polypeptide 1; TF3C-alpha; TFIIIC 220 kDa subunit; TFIIIC box B-binding subunit; TFIIIC220; Transcription factor IIIC 220 kDa subunit; Transcription factor IIIC subunit alpha", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:171063); (R-RNO-76061); (R-RNO-76066)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8164661", "class_list": "", "function": "Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000995 RNA polymerase III general transcription initiation factor activity", "go_cellular_component": "GO:0000127 transcription factor TFIIIC complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0042791 5S class rRNA transcription by RNA polymerase III;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63505-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64380-1", "uniprot_id": [ { "id": "SARDH_RAT", "url": "https://www.uniprot.org/uniprot/Q64380", "type": "external" } ], "mass": 101440.0, "length": 919, "protein_name": "Sarcosine dehydrogenase, mitochondrial", "gene_name": "Sardh", "organism": "Rat", "refseq_name": "sarcosine dehydrogenase, mitochondrial", "refseq_ac": [ { "id": "NP_446116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446116", "type": "external" } ], "gene_names_uniprotkb": "Sardh", "gene_names_refseq": "Sardh", "protein_names_uniprotkb": "Sarcosine dehydrogenase, mitochondrial; 1.5.8.3; SarDH", "protein_names_refseq": "sarcosine dehydrogenase, mitochondrial", "tax_id": 10116, "disease": "sarcosinemia (Disease Ontology:DOID:0112307); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:114123); (R-RNO-6798163)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "4055729;6163778;9839943", "class_list": "", "function": "Catalyzes the last step of the oxidative degradation of choline to glycine. Converts sarcosine into glycine., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88499", "ec_number_list": [ { "id": "1.5.8.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.8.3", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0016491 oxidoreductase activity;GO:0005542 folic acid binding;GO:0008480 sarcosine dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006545 glycine biosynthetic process;GO:0042426 choline catabolic process;GO:1901053 sarcosine catabolic process;GO:0035999 tetrahydrofolate interconversion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q64380-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61959-1", "uniprot_id": [ { "id": "SUMO2_RAT", "url": "https://www.uniprot.org/uniprot/P61959", "type": "external" } ], "mass": 10871.0, "length": 95, "protein_name": "Small ubiquitin-related modifier 2", "gene_name": "ENSRNOG00000063545; Jpt1; Sumo2", "organism": "Rat", "refseq_name": "small ubiquitin-related modifier 2", "refseq_ac": [ { "id": "NP_598278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598278", "type": "external" } ], "gene_names_uniprotkb": "ENSRNOG00000063545; Jpt1; Sumo2; Smt3a; Smt3h2; Sumo2; Sumo4", "gene_names_refseq": "Smt3A; Smt3h2; Sumo2", "protein_names_uniprotkb": "Small ubiquitin-related modifier 2; SMT3 homolog 2; SUMO-2; Sentrin-2; Smt3A; Ubiquitin-like protein SMT3A", "protein_names_refseq": "SMT3 homolog 2; SMT3 suppressor of mif two 3 homolog 2; SUMO-2; sentrin-2; small ubiquitin-related modifier 2; ubiquitin-like protein SMT3A; ubiquitin-like protein SMT3B", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:690244); (R-RNO-3065679); (R-RNO-3108214); (R-RNO-3232118); (R-RNO-3899300); (R-RNO-4090294); (R-RNO-4551638); (R-RNO-4615885); (R-RNO-4755510); (R-RNO-5696395)", "pathway_count": 10, "publication_count": 3, "publication_id_list": "22891650;24971350;37403456", "class_list": "", "function": "Exposure to moderate 30 degrees C hypothermia in rats is sufficient to markedly modify the pattern and subcellular localization of SUMO2/3 in neurons; hypothermia triggers nuclear translocation of the SUMO-conjugating enzyme Ubc9., [RefSeq, PubMed]; SENP5 deteriorates traumatic brain injury via SUMO2-dependent suppression of E2F1 SUMOylation., [RefSeq, PubMed]; These results suggest that high glucose may activate TGF- beta/Smad signaling through sumoylation of Samd4 by SUMO2/3 in mesangial cells., [RefSeq, PubMed]; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P55855", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0019789 SUMO transferase activity;GO:0046965 nuclear retinoid X receptor binding;GO:0044389 ubiquitin-like protein ligase binding;GO:0031386 protein tag activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0098794 postsynapse", "go_biological_process": "GO:0016925 protein sumoylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0008104 intracellular protein localization;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P61959-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q58FK9-1", "uniprot_id": [ { "id": "KAT3_RAT", "url": "https://www.uniprot.org/uniprot/Q58FK9", "type": "external" } ], "mass": 51044.0, "length": 454, "protein_name": "Kynurenine--oxoglutarate transaminase 3", "gene_name": "Kyat3", "organism": "Rat", "refseq_name": "kynurenine--oxoglutarate transaminase 3", "refseq_ac": [ { "id": "NP_001015037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015037", "type": "external" } ], "gene_names_uniprotkb": "Kyat3; Ccbl2; Kat3", "gene_names_refseq": "Ccbl2; Kat3; Kyat3", "protein_names_uniprotkb": "Kynurenine--oxoglutarate transaminase 3; 2.6.1.63; 2.6.1.7; 4.4.1.13; Cysteine-S-conjugate beta-lyase 2; KATIII; Kynurenine aminotransferase 3; Kynurenine aminotransferase III; Kynurenine--glyoxylate transaminase; Kynurenine--oxoglutarate transaminase III", "protein_names_refseq": "KATIII; cysteine conjugate-beta lyase 2; cysteine-S-conjugate beta-lyase 2; kynurenine aminotransferase III-like; kynurenine aminotransferase III; kynurenine--glyoxylate transaminase; kynurenine--oxoglutarate transaminase 3; kynurenine--oxoglutarate transaminase III", "tax_id": 10116, "disease": "", "pathway": " (rno:541589)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16376499", "class_list": "", "function": "Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.7", "type": "external" }, { "id": "2.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.1", "type": "external" }, { "id": "2.6.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.64", "type": "external" }, { "id": "4.4.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.13", "type": "external" }, { "id": "2.6.1.63", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.63", "type": "external" }, { "id": "2.6.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.39", "type": "external" }, { "id": "2.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.4", "type": "external" }, { "id": "2.6.1.73", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.73", "type": "external" } ], "go_molecular_function": "GO:0047315 kynurenine-glyoxylate transaminase activity;GO:0016212 kynurenine-oxoglutarate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0042803 protein homodimerization activity;GO:0047804 cysteine-S-conjugate beta-lyase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0097053 L-kynurenine catabolic process;GO:0006103 2-oxoglutarate metabolic process;GO:0070189 kynurenine metabolic process;GO:0006520 amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q58FK9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08013-1", "uniprot_id": [ { "id": "SSRG_RAT", "url": "https://www.uniprot.org/uniprot/Q08013", "type": "external" } ], "mass": 21064.0, "length": 185, "protein_name": "Translocon-associated protein subunit gamma", "gene_name": "Ssr3", "organism": "Rat", "refseq_name": "translocon-associated protein subunit gamma", "refseq_ac": [ { "id": "NP_112382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112382", "type": "external" } ], "gene_names_uniprotkb": "Ssr3", "gene_names_refseq": "Ssr3", "protein_names_uniprotkb": "Translocon-associated protein subunit gamma; SSR-gamma; Signal sequence receptor subunit gamma; TRAP-gamma", "protein_names_refseq": "SSR-gamma; TRAP-complex gamma subunit; TRAP-gamma; signal sequence receptor subunit gamma; signal sequence receptor, gamma; translocon-associated protein subunit gamma", "tax_id": 10116, "disease": "", "pathway": " (rno:81784)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;7916687", "class_list": "", "function": "TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6U5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005784 Sec61 translocon complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006614 SRP-dependent cotranslational protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q08013-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81377-1", "uniprot_id": [ { "id": "KAP1_RAT", "url": "https://www.uniprot.org/uniprot/P81377", "type": "external" } ], "mass": 43282.0, "length": 381, "protein_name": "cAMP-dependent protein kinase type I-beta regulatory subunit", "gene_name": "Prkar1b", "organism": "Rat", "refseq_name": "cAMP-dependent protein kinase type I-beta regulatory subunit isoform 1", "refseq_ac": [ { "id": "NP_001405604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001405604", "type": "external" } ], "gene_names_uniprotkb": "Prkar1b", "gene_names_refseq": "Prkar1b; RGD1563094; RIbeta", "protein_names_uniprotkb": "cAMP-dependent protein kinase type I-beta regulatory subunit", "protein_names_refseq": "cAMP dependent protein kinase, subunit type 1 beta; cAMP-dependent protein kinase type I-beta regulatory subunit isoform 1; cAMP-dependent protein kinase type I-beta regulatory subunit; protein kinase cAMP-dependent type 1 regulatory subunit beta; protein kinase, cAMP dependent regulatory, type I, beta; protein kinase, cAMP-dependent, regulatory subunit type I beta", "tax_id": 10116, "disease": "aortic dissection (Disease Ontology:DOID:0080685); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:25521); (R-RNO-163615); (R-RNO-164378); (R-RNO-180024); (R-RNO-432040); (R-RNO-442720); (R-RNO-5610787); (R-RNO-9634597); (R-RNO-983231); (R-RNO-9856530)", "pathway_count": 10, "publication_count": 2, "publication_id_list": "2372396;33479380", "class_list": "", "function": "Deficiency of the RIbeta subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats. Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0008603 cAMP-dependent protein kinase regulator activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007611 learning or memory;GO:1900273 positive regulation of long-term synaptic potentiation;GO:2000463 positive regulation of excitatory postsynaptic potential;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P81377-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55205-1", "uniprot_id": [ { "id": "GUC2G_RAT", "url": "https://www.uniprot.org/uniprot/P55205", "type": "external" } ], "mass": 122497.0, "length": 1100, "protein_name": "Guanylate cyclase 2G", "gene_name": "Gucy2g", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gucy2g; Ksgc", "gene_names_refseq": "", "protein_names_uniprotkb": "Guanylate cyclase 2G; 4.6.1.2; GC-G; Guanylyl cyclase receptor G; Kinase-like domain-containing soluble guanylyl cyclase; ksGC", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:245708)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8554626;9422765", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O54884", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0001653 peptide receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007168 receptor guanylyl cyclase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P55205-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T1I5-1", "uniprot_id": [ { "id": "SRBP2_RAT", "url": "https://www.uniprot.org/uniprot/Q3T1I5", "type": "external" } ], "mass": 122976.0, "length": 1133, "protein_name": "Sterol regulatory element-binding protein 2", "gene_name": "Srebf2", "organism": "Rat", "refseq_name": "sterol regulatory element-binding protein 2", "refseq_ac": [ { "id": "NP_001028866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028866", "type": "external" } ], "gene_names_uniprotkb": "Srebf2", "gene_names_refseq": "SREBP-2; SREBP2; Srebf2_retired; Srebf2", "protein_names_uniprotkb": "Sterol regulatory element-binding protein 2; SREBP-2; Sterol regulatory element-binding transcription factor 2; Transcription factor SREBF2", "protein_names_refseq": "sterol regulatory element binding factor 2; sterol regulatory element-binding protein 2", "tax_id": 10116, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); heart conduction disease (Disease Ontology:DOID:10273); prostate cancer (Disease Ontology:DOID:10283); sarcoma (Disease Ontology:DOID:1115); alcohol use disorder (Disease Ontology:DOID:1574); nephrosis (Disease Ontology:DOID:2527); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); kidney disease (Disease Ontology:DOID:557); end stage renal disease (Disease Ontology:DOID:783); vascular dementia (Disease Ontology:DOID:8725); type 2 diabetes mellitus (Disease Ontology:DOID:9352); lipid storage disease (Disease Ontology:DOID:9455); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:300095); (R-RNO-1655829); (R-RNO-6807062)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "29446047;30579780;37844755", "class_list": "", "function": "EGCG can alleviate liver injury and oxidative stress in hyperlipidemic rats. EGCG can activate SIRT1, activate FOXO1 protein, regulate SREBP-2 protein, and inhibit hepatic cholesterol synthesis., [RefSeq, PubMed]; High-salt diet induces dyslipidemia through the SREBP2/PCSK9 pathway in dahl salt-sensitive rats., [RefSeq, PubMed]; Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Regulates transcription of genes related to cholesterol synthesis pathway. Regulates hepatic lipogenesis., [UniProtKB, UniProtKB]; Mitochondrial AQP8 is involved in SREBP2-controlled hepatocyte cholesterol biosynthesis., [RefSeq, PubMed]; Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane. Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0008203 cholesterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3T1I5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97590-1", "uniprot_id": [ { "id": "LEG7_RAT", "url": "https://www.uniprot.org/uniprot/P97590", "type": "external" } ], "mass": 15285.0, "length": 136, "protein_name": "Galectin-7", "gene_name": "Lgals7", "organism": "Rat", "refseq_name": "galectin-7", "refseq_ac": [ { "id": "NP_072104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072104", "type": "external" } ], "gene_names_uniprotkb": "Lgals7", "gene_names_refseq": "Lgals7", "protein_names_uniprotkb": "Galectin-7; Gal-7", "protein_names_refseq": "gal-7; galectin-7; lectin, galactose binding, soluble 7; lectin, galactoside-binding, soluble, 7", "tax_id": 10116, "disease": "", "pathway": " (rno:29518)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21677144;33416139;9697310", "class_list": "", "function": "Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release (By similarity)., [UniProtKB]; Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells., [RefSeq, PubMed]; Ultrasoundtargeted microbubble destructionmediated Galectin7siRNA promotes the homing of bone marrow mesenchymal stem cells to alleviate acute myocardial infarction in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54958", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0001533 cornified envelope", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97590-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09030-1", "uniprot_id": [ { "id": "TFF2_RAT", "url": "https://www.uniprot.org/uniprot/Q09030", "type": "external" } ], "mass": 14077.0, "length": 129, "protein_name": "Trefoil factor 2", "gene_name": "Tff2", "organism": "Rat", "refseq_name": "trefoil factor 2 precursor", "refseq_ac": [ { "id": "NP_446296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446296", "type": "external" } ], "gene_names_uniprotkb": "Tff2; Sml1", "gene_names_refseq": "Tff2", "protein_names_uniprotkb": "Trefoil factor 2; SP; Spasmolytic polypeptide", "protein_names_refseq": "SP; spasmolytic polypeptide; trefoil factor 2 (spasmolytic protein 1); trefoil factor 2 precursor", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (rno:116592)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12388439;12918118;19741170;24588600;8299900", "class_list": "", "function": "INOS-derived NO associated with NSAID-induced gastric injury is implicated in mucosal restitution via the HIF-1-mediated induction of TFF2 genes., [RefSeq, PubMed]; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains., [UniProtKB, UniProtKB, UniProtKB]; Keratinocyte growth factor enhances TFF2 expression in proximal small bowel and increases goblet cell number and TFF3 protein content throughout the intestine independent of food intake, [RefSeq, PubMed]; Substantial amounts of TFF1 were detected only in the cytoplasm of epithelial cells in the submandibular glands granular convoluted tubules (GCT), while TFF2 and TFF3 were widely distributed in the cytoplasm of epithelial cells of intercalated ducts, [RefSeq, PubMed]; TFF may not only participate in the early phase of epithelial repair known as restitution (maked by increased cell migration), but also play an important role in the subsequent, protracted phase of glandular renewal(made by cell proliferation)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0008083 growth factor activity;GO:0031723 CXCR4 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0060455 negative regulation of gastric acid secretion;GO:0008284 positive regulation of cell population proliferation;GO:0019722 calcium-mediated signaling;GO:0070098 chemokine-mediated signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q09030-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I2P1-1", "uniprot_id": [ { "id": "TBX5_RAT", "url": "https://www.uniprot.org/uniprot/Q5I2P1", "type": "external" } ], "mass": 57745.0, "length": 517, "protein_name": "T-box transcription factor TBX5", "gene_name": "Tbx5", "organism": "Rat", "refseq_name": "T-box transcription factor TBX5", "refseq_ac": [ { "id": "NP_001009964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009964", "type": "external" } ], "gene_names_uniprotkb": "Tbx5", "gene_names_refseq": "Tbx5", "protein_names_uniprotkb": "T-box transcription factor TBX5; T-box protein 5", "protein_names_refseq": "T-box 5; T-box protein 5; T-box transcription factor TBX5", "tax_id": 10116, "disease": "Holt-Oram syndrome (Disease Ontology:DOID:0060468); myocardial infarction (Disease Ontology:DOID:5844); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:304514); (R-RNO-2032785)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "28100873;30720154;31265161", "class_list": "", "function": "DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. Binds to the core DNA motif of NPPA promoter., [UniProtKB, UniProtKB]; MiR-10a may inhibit cardiac hypertrophy via targeting Tbx5., [RefSeq, PubMed]; The MicroRNA-10-5p regulates BMSCs differentiation into cardiomyocytes by binding to TBX5., [RefSeq, PubMed]; Transcription factor Tbx5 promotes cardiomyogenic differentiation of cardiac fibroblasts treated with 5-azacytidine., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0001708 cell fate specification;GO:0003166 bundle of His development;GO:0060929 atrioventricular node cell fate commitment;GO:0051891 positive regulation of cardioblast differentiation;GO:0003167 atrioventricular bundle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5I2P1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63673-1", "uniprot_id": [ { "id": "SHH_RAT", "url": "https://www.uniprot.org/uniprot/Q63673", "type": "external" } ], "mass": 47630.0, "length": 437, "protein_name": "Sonic hedgehog protein", "gene_name": "Shh", "organism": "Rat", "refseq_name": "sonic hedgehog protein precursor", "refseq_ac": [ { "id": "NP_058917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058917", "type": "external" } ], "gene_names_uniprotkb": "Shh; Vhh-1", "gene_names_refseq": "ShhNC; Shh", "protein_names_uniprotkb": "Sonic hedgehog protein; 3.1.-.-; SHH; Shh N-terminal processed signaling domains; Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; ShhNC; ShhNp", "protein_names_refseq": "shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; sonic hedgehog homolog; sonic hedgehog protein precursor; sonic hedgehog protein", "tax_id": 10116, "disease": "primary bacterial infectious disease (Disease Ontology:DOID:0050338); primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); autism spectrum disorder (Disease Ontology:DOID:0060041); pre-malignant neoplasm (Disease Ontology:DOID:0060071); preaxial polydactyly II (Disease Ontology:DOID:0060986); esophageal atresia/tracheoesophageal fistula (Disease Ontology:DOID:0080171); Parkinsonism (Disease Ontology:DOID:0080855); hypogonadotropic hypogonadism 20 with or without anosmia (Disease Ontology:DOID:0090082); holoprosencephaly 3 (Disease Ontology:DOID:0110875); solitary median maxillary central incisor (Disease Ontology:DOID:0111380); hypoplastic or aplastic tibia with polydactyly (Disease Ontology:DOID:0111564); syndactyly type 4 (Disease Ontology:DOID:0111818); Hirschsprung's disease (Disease Ontology:DOID:10487); stomach cancer (Disease Ontology:DOID:10534); membranous glomerulonephritis (Disease Ontology:DOID:10976); polydactyly (Disease Ontology:DOID:1148); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); biliary atresia (Disease Ontology:DOID:13608); hypothyroidism (Disease Ontology:DOID:1459); VACTERL association (Disease Ontology:DOID:14679); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); nevoid basal cell carcinoma syndrome (Disease Ontology:DOID:2512); basal cell carcinoma (Disease Ontology:DOID:2513); IgA glomerulonephritis (Disease Ontology:DOID:2986); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); holoprosencephaly (Disease Ontology:DOID:4621); myocardial infarction (Disease Ontology:DOID:5844); chronic kidney disease (Disease Ontology:DOID:784); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); colorectal cancer (Disease Ontology:DOID:9256); ocular hypertension (Disease Ontology:DOID:9282)", "pathway": " (rno:29499); (R-RNO-5358346); (R-RNO-5362798); (R-RNO-5632681)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "11395778;32980902;33012205;35147838;36906487;37815888;8124714", "class_list": "", "function": "Impaired Hedgehog-Gli1 Pathway Activity Underlies the Vascular Phenotype of Polycystic Kidney Disease., [RefSeq, PubMed]; Overexpression of sonic hedgehog enhances the osteogenesis in rat ectomesenchymal stem cells., [RefSeq, PubMed]; Precursor of sonic hedgehog, a morphogen that activates the smoothened signaling pathway, and which is essential for a variety of patterning events during development (By similarity). The C-terminal part of the precursor displays an autoproteolysis and a cholesterol transferase activity, resulting (1) in the cleavage of the full-length protein into two parts, Sonic hedgehog protein N-product and C-product (ShhN and ShhC, respectively) and (2) covalent attachment of a cholesterol moiety to the C-terminus of the newly generated ShhN (By similarity). Both autoproteolysis and a cholesterol transferase activities occur in the endoplasmic reticulum (By similarity). Following additional lipidation, ShhN acts as a morphogen, while ShhC is degraded in the endoplasmic reticulum (By similarity)., [UniProtKB, UniProtKB]; Regulation of Shh/Bmp4 Signaling Pathway by DNA Methylation in Rectal Nervous System Development of Fetal Rats with Anorectal Malformation., [RefSeq, PubMed]; Shenkang VII Recipe Attenuates Unilateral Ureteral Obstruction-induced Renal Fibrosis via TGF-beta/Smad, NF-kappaB and SHH Signaling Pathway., [RefSeq, PubMed]; Sonic hedgehog signaling promotes angiogenesis of endothelial progenitor cells to improve pressure ulcers healing by PI3K/AKT/eNOS signaling. Erratum:[Aging (Albany NY). 2023 Dec 29;15(24):15703-15704. doi: 10.18632/aging.205458. PMID: 38157439], [RefSeq, PubMed]; The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product., [UniProtKB, UniProtKB]; The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development., [UniProtKB, UniProtKB]; The dually lipidated sonic hedgehog protein N-product (ShhN) is a morphogen that activates the smoothened signaling pathway, and which is essential for a variety of patterning events during development (By similarity). Acts by binding to the patched receptor (PTCH1 or PTCH2), relieving smoothened (SMO) inhibition by patched, activating the smoothened signaling pathway and transcription of target genes (By similarity). In the absence of SHH, patched represses the constitutive signaling activity of SMO (By similarity). ShhN is widely expressed and plays a key role in the patterning of the central nervous system and limb development (By similarity). Induces ventral cell fate in the neural tube and somites (By similarity). Involved in the patterning of the anterior-posterior axis of the developing limb bud (By similarity). Essential for axon guidance (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 33, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0008233 peptidase activity;GO:0005539 glycosaminoglycan binding;GO:0005113 patched binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0030878 thyroid gland development;GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment;GO:0001708 cell fate specification;GO:0045880 positive regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63673-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0M0-1", "uniprot_id": [ { "id": "SETMR_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0M0", "type": "external" } ], "mass": 35030.0, "length": 315, "protein_name": "Histone-lysine N-methyltransferase SETMAR", "gene_name": "Setmar", "organism": "Rat", "refseq_name": "histone-lysine N-methyltransferase SETMAR", "refseq_ac": [ { "id": "NP_001020219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020219", "type": "external" } ], "gene_names_uniprotkb": "Setmar", "gene_names_refseq": "Setmar", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SETMAR; 2.1.1.357; SET domain and mariner transposase fusion protein homolog", "protein_names_refseq": "SET domain and mariner transposase fusion gene-containing protein homolog; SET domain and mariner transposase fusion protein homolog; SET domain without mariner transposase fusion; histone-lysine N-methyltransferase SETMAR", "tax_id": 10116, "disease": "", "pathway": " (rno:500281)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a histone-lysine N-methyltransferase that may be involved in the methylation of histone H3. In anthropoid primates this gene is a fusion gene of a SET histone-lysine N-methyltransferase and a mariner (MAR) family transposase. In all other species this gene contains only the SET domain. [provided by RefSeq, Feb 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0003690 double-stranded DNA binding;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000793 condensed chromosome;GO:0035861 site of double-strand break;GO:0005694 chromosome", "go_biological_process": "GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity;GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0044774 mitotic DNA integrity checkpoint signaling;GO:2001251 negative regulation of chromosome organization;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0M0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLG3-1", "uniprot_id": [ { "id": "SVBP_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLG3", "type": "external" } ], "mass": 7836.0, "length": 66, "protein_name": "Small vasohibin-binding protein", "gene_name": "Svbp", "organism": "Rat", "refseq_name": "small vasohibin-binding protein isoform b", "refseq_ac": [ { "id": "NP_001034081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034081", "type": "external" } ], "gene_names_uniprotkb": "Svbp; Ccdc23", "gene_names_refseq": "Ccdc23; RGD1311232; Svbp", "protein_names_uniprotkb": "Small vasohibin-binding protein; Coiled coil domain-containing protein 23", "protein_names_refseq": "coiled-coil domain containing 23; coiled-coil domain-containing protein 23; small vasohibin-binding protein isoform b", "tax_id": 10116, "disease": "", "pathway": " (rno:362578)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30607023", "class_list": "", "function": "Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin. Also required to enhance the solubility and secretion of VASH1 and VASH2. Plays a role in axon and excitatory synapse formation (PubMed:30607023)., [UniProtKB, PubMed, UniProtKB]; Knocking down Svbp in rat primary hippocampal neurons led to a significant decrease in the number of excitatory synapses. SVBP is not only involved in angiogenesis, but also has vital functions in the central nervous system. Biallelic loss-of-function variants in SVBP lead to intellectual disability., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0016504 peptidase activator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0045177 apical part of cell", "go_biological_process": "GO:0006508 proteolysis;GO:0007420 brain development;GO:0010596 negative regulation of endothelial cell migration;GO:0009306 protein secretion;GO:0031397 negative regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KLG3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4L208-1", "uniprot_id": [ { "id": "SL9A8_RAT", "url": "https://www.uniprot.org/uniprot/Q4L208", "type": "external" } ], "mass": 64609.0, "length": 575, "protein_name": "Sodium/hydrogen exchanger 8", "gene_name": "Slc9a8", "organism": "Rat", "refseq_name": "sodium/hydrogen exchanger 8", "refseq_ac": [ { "id": "NP_001020452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020452", "type": "external" } ], "gene_names_uniprotkb": "Slc9a8; Nhe8", "gene_names_refseq": "Slc9a8", "protein_names_uniprotkb": "Sodium/hydrogen exchanger 8; NHE-8; Na(+)/H(+) exchanger 8; Solute carrier family 9 member 8", "protein_names_refseq": "NHE-8; Na(+)/H(+) exchanger 8; sodium/hydrogen exchanger 8; solute carrier family 9 (sodium/hydrogen exchanger), member 8; solute carrier family 9 member 8; solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8", "tax_id": 10116, "disease": "", "pathway": " (rno:311651); (R-RNO-425986)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12409279;15522984;15731506;17581925;18209477;19109523;20375273;22088432;31042050;34288721", "class_list": "", "function": "EGF inhibits intestinal NHE8 gene expression by reducing its basal transcription., [RefSeq, PubMed]; Functional characterization of the sodium/hydrogen exchanger 8 and its role in proliferation of colonic epithelial cells., [RefSeq, PubMed]; NHE-8 may play an important role in intestinal Na+ absorption during early life, [RefSeq, PubMed]; NHE8 protein is expressed in the apical membrane of NRK cells as demonstrated by immunoblots, confocal fluorescent immunocytochemistry, and immunoelectron microscopy., [RefSeq, PubMed]; NHE8 regulates Ca(2+) uptake into the proximal tubule epithelium., [RefSeq, PubMed]; Na(+)/H(+) antiporter. Mediates the electoneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry. Acts as an Na(+)/H(+) exchanger in the trans-Golgi. Contributes to the regulation of pH regulation of Golgi apparatus, and consequently, in protein trafficking and endosomal morphology (By similarity). In germ cells, plays a crucial role in acrosome biogenesis and sperm development, probably by playing a role in the fusion of the Golgi-derived vesicles that form the acrosomal cap (By similarity). Can also be active at the cell surface of specialized cells (PubMed:22088432). In the small intestine, at the cell membrane, plays a major physiological role in transepithelial absorption of Na(+) and regulates intracellular pH homeostasis of intestinal epithelial cells (PubMed:18209477, PubMed:34288721). Acts as an important regulator of mucosal integrity in the intestine and in the stomach, could mediate the pH fluctuation necessary for mucin exocytosis or assist membrane trafficking of other proteins. Plays a role in photoreceptor survival and in the maintenance of intracellular pH homeostasis in retinal pigment epithelium (RPE cells) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Tumor necrosis factor-alpha downregulates intestinal NHE8 expression by reducing basal promoter activity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015386 potassium:proton antiporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0032588 trans-Golgi network membrane;GO:0016324 apical plasma membrane;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006813 potassium ion transport;GO:0035725 sodium ion transmembrane transport;GO:0001675 acrosome assembly;GO:0006814 sodium ion transport;GO:0051453 regulation of intracellular pH", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q4L208-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63059-1", "uniprot_id": [ { "id": "THA_RAT", "url": "https://www.uniprot.org/uniprot/P63059", "type": "external" } ], "mass": 55072.0, "length": 492, "protein_name": "Thyroid hormone receptor alpha", "gene_name": "Thra", "organism": "Rat", "refseq_name": "thyroid hormone receptor alpha isoform TRalpha1", "refseq_ac": [ { "id": "NP_001017960", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017960", "type": "external" } ], "gene_names_uniprotkb": "Thra; C-erba-alpha; Nr1a1", "gene_names_refseq": "ERBA1; Thra1; Thra; c-erbA-1", "protein_names_uniprotkb": "Thyroid hormone receptor alpha; Nuclear receptor subfamily 1 group A member 1; c-erbA-1; c-erbA-alpha", "protein_names_refseq": "C-erbA-alpha; c-erb-A thyroid hormone receptor; c-erbA-alpha2; c-erbAalpha2; nuclear receptor subfamily 1 group A member 1; thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1); thyroid hormone receptor alpha isoform TRalpha1", "tax_id": 10116, "disease": "congenital nongoitrous hypothyroidism 6 (Disease Ontology:DOID:0070128); thyroid hormone resistance syndrome (Disease Ontology:DOID:11633); hypothyroidism (Disease Ontology:DOID:1459); breast cancer (Disease Ontology:DOID:1612); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (rno:81812); (R-RNO-383280); (R-RNO-4090294)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10866662;25156012;25726374;26861177;2841611;2903438;31534055;33255695;3387247;3629259;7501015", "class_list": "", "function": "Alteration of thyroid hormone signaling triggers the diabetes-induced pathological growth, remodeling, and dedifferentiation of podocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Down-regulated in hepatocellular carcinoma, [RefSeq, PubMed]; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine., [UniProtKB]; The roles of nitric oxide synthase and TRalph1 in hyperthyroid and hypothyroid rats are reported., [RefSeq, PubMed]; This study demonstrated that reduction of the thyroid hormone receptor alfa (Tralpha1)mRNA expression in hippocampus of thyroidectomized Wistar rats., [RefSeq, PubMed]; Thyroid Hormone Signaling in Embryonic Stem Cells: Crosstalk with the Retinoic Acid Pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P10685;P15827;P16416;P37241;Q63107;Q63195;Q63196;Q99146", "ec_number_list": [], "go_molecular_function": "GO:0002153 steroid receptor RNA activator RNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0030878 thyroid gland development;GO:0017055 negative regulation of RNA polymerase II transcription preinitiation complex assembly;GO:0033032 regulation of myeloid cell apoptotic process;GO:0002155 regulation of thyroid hormone receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P63059-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02253-1", "uniprot_id": [ { "id": "MMSA_RAT", "url": "https://www.uniprot.org/uniprot/Q02253", "type": "external" } ], "mass": 57808.0, "length": 535, "protein_name": "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial", "gene_name": "Aldh6a1", "organism": "Rat", "refseq_name": "methylmalonate-semialdehyde/malonate- semialdehyde dehydrogenase [acylating], mitochondrial precursor", "refseq_ac": [ { "id": "NP_112319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112319", "type": "external" } ], "gene_names_uniprotkb": "Aldh6a1; Mmsdh", "gene_names_refseq": "Aldh6a1; Mmsdh", "protein_names_uniprotkb": "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial; 1.2.1.27; Aldehyde dehydrogenase family 6 member A1; MMSDH", "protein_names_refseq": "aldehyde dehydrogenase family 6 member A1; aldehyde dehydrogenase family 6, subfamily A1; malonate-semialdehyde dehydrogenase; methylmalonate semialdehyde dehydrogenase; methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; methylmalonate-semialdehyde/malonate- semialdehyde dehydrogenase [acylating], mitochondrial precursor; methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:81708); (R-RNO-70895)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1527093;1898092;20966424;22207704;26446791;27213235;2768248;34502162", "class_list": "", "function": "Malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Suggest that MMSDH protein is present in the entire epididymis; its expression is regulated by androgen and the developmental status of the epididymis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.2.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.27", "type": "external" } ], "go_molecular_function": "GO:0016790 thiolester hydrolase activity;GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006210 thymine catabolic process;GO:0050873 brown fat cell differentiation;GO:0006574 L-valine catabolic process;GO:0006573 valine metabolic process;GO:0019859 thymine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q02253-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05702-1", "uniprot_id": [ { "id": "SG1C1_RAT", "url": "https://www.uniprot.org/uniprot/Q05702", "type": "external" } ], "mass": 10401.0, "length": 94, "protein_name": "Secretoglobin family 1C member 1", "gene_name": "Scgb1c1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Scgb1c1; Ryd5", "gene_names_refseq": "", "protein_names_uniprotkb": "Secretoglobin family 1C member 1; Secretoglobin RYD5", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:309100)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1915264", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q05702-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q11205-1", "uniprot_id": [ { "id": "SIA4B_RAT", "url": "https://www.uniprot.org/uniprot/Q11205", "type": "external" } ], "mass": 40166.0, "length": 350, "protein_name": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2", "gene_name": "St3gal2", "organism": "Rat", "refseq_name": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 2", "refseq_ac": [ { "id": "NP_113883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113883", "type": "external" } ], "gene_names_uniprotkb": "St3gal2; Siat4b; Siat5", "gene_names_refseq": "Siat4b; Siat5; St3gal2", "protein_names_uniprotkb": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2; 2.4.3.2; 2.4.3.4; Alpha 2,3-ST 2; Beta-galactoside alpha-2,3-sialyltransferase 2; Gal-NAc6S; Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; Monosialoganglioside sialyltransferase; SIAT4-B; ST3Gal II; ST3GalA.2; ST3GalII; Sialyltransferase 4B", "protein_names_refseq": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 2; SIAT4-B; ST3GALA.2; ST3Gal II; ST3GalII; alpha 2,3-ST 2; beta-galactoside alpha-2,3-sialyltransferase 2; gal-NAc6S; gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; monosialoganglioside sialyltransferase; sialyltransferase 4B (beta-galactoside alpha-2,3-sialyltransferase); sialyltransferase 5", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:64442); (R-RNO-2022854); (R-RNO-4085001); (R-RNO-977068); (R-RNO-9840309)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "21913655;8144500", "class_list": "glycogene;glycosyltransferase", "function": "A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8144500). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage. Sialylates GM1/GM1a, GA1/asialo-GM1 gangliosides to form GD1a and GM1b, respectively (PubMed:8144500). Together with ST3GAL3, primarily responsible for biosynthesis of brain gangliosides that function as ligand for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (By similarity). Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4 (By similarity). Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser (PubMed:8144500)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Use of sialyl mucin core 2 compounds shows how ST3Gal-II exchanges sialyl residues between CMP-NeuAc and the NeuAcalpha2,3Galbeta1,3GalNAc unit, while also radiolabeling sialyl residues in gangliosides GD1a and GT1b, but not GM1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.2", "type": "external" }, { "id": "2.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.4", "type": "external" }, { "id": "3.6.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.59", "type": "external" }, { "id": "2.4.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.6", "type": "external" }, { "id": "2.4.3.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.9", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0008373 sialyltransferase activity;GO:0047288 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase;GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0016020 membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0001576 globoside biosynthetic process;GO:0009101 glycoprotein biosynthetic process;GO:0009247 glycolipid biosynthetic process;GO:0009312 oligosaccharide biosynthetic process;GO:0097503 sialylation", "synthesized_glycan_count": 412, "hit_score": 0.3, "record_id": "Q11205-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q499W2-1", "uniprot_id": [ { "id": "SLD5_RAT", "url": "https://www.uniprot.org/uniprot/Q499W2", "type": "external" } ], "mass": 26062.0, "length": 223, "protein_name": "DNA replication complex GINS protein SLD5", "gene_name": "Gins4", "organism": "Rat", "refseq_name": "DNA replication complex GINS protein SLD5", "refseq_ac": [ { "id": "NP_001025198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025198", "type": "external" } ], "gene_names_uniprotkb": "Gins4; Sld5", "gene_names_refseq": "2810037c03rik; Gins4; RGD1307397", "protein_names_uniprotkb": "DNA replication complex GINS protein SLD5; GINS complex subunit 4", "protein_names_refseq": "DNA replication complex GINS protein SLD5; GINS complex subunit 4 (Sld5 homolog); SLD5", "tax_id": 10116, "disease": "", "pathway": " (rno:290842); (R-RNO-176974)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000811 GINS complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006260 DNA replication;GO:0000727 double-strand break repair via break-induced replication;GO:0006261 DNA-templated DNA replication;GO:0001833 inner cell mass cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q499W2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54100-1", "uniprot_id": [ { "id": "VAV_RAT", "url": "https://www.uniprot.org/uniprot/P54100", "type": "external" } ], "mass": 97954.0, "length": 843, "protein_name": "Proto-oncogene vav", "gene_name": "Vav1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Vav1; Vav", "gene_names_refseq": "", "protein_names_uniprotkb": "Proto-oncogene vav; p95", "protein_names_refseq": "", "tax_id": 10116, "disease": "Friedreich ataxia 1 (Disease Ontology:DOID:0111218); Friedreich ataxia (Disease Ontology:DOID:12705); cancer (Disease Ontology:DOID:162); iron metabolism disease (Disease Ontology:DOID:2351); endometriosis (Disease Ontology:DOID:289); glioblastoma (Disease Ontology:DOID:3068); lymphopenia (Disease Ontology:DOID:614); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:25156); (R-RNO-114604); (R-RNO-1257604); (R-RNO-1433557); (R-RNO-193648); (R-RNO-2029482); (R-RNO-2871796); (R-RNO-2871809); (R-RNO-389359); (R-RNO-416482); (R-RNO-4420097); (R-RNO-512988); (R-RNO-5218920); (R-RNO-6811558); (R-RNO-8980692); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013408); (R-RNO-9027284); (R-RNO-912631); (R-RNO-9748787); (R-RNO-983695)", "pathway_count": 22, "publication_count": 2, "publication_id_list": "10395673;29393594", "class_list": "", "function": "Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0140031 phosphorylation-dependent protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005911 cell-cell junction", "go_biological_process": "GO:0006955 immune response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P54100-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI01-1", "uniprot_id": [ { "id": "LARP7_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI01", "type": "external" } ], "mass": 64949.0, "length": 571, "protein_name": "La-related protein 7", "gene_name": "Larp7", "organism": "Rat", "refseq_name": "la-related protein 7", "refseq_ac": [ { "id": "NP_001037755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037755", "type": "external" } ], "gene_names_uniprotkb": "Larp7", "gene_names_refseq": "Larp7", "protein_names_uniprotkb": "La-related protein 7; La ribonucleoprotein domain family member 7", "protein_names_refseq": "La ribonucleoprotein domain family, member 7; la-related protein 7", "tax_id": 10116, "disease": "", "pathway": " (rno:686883)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function. Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II. The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex. LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing. Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes. U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity. Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (By similarity). U6 snRNA processing is required for spermatogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0097322 7SK snRNA binding;GO:0017070 U6 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:1990904 ribonucleoprotein complex;GO:0120259 7SK snRNP", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:1904871 positive regulation of protein localization to Cajal body;GO:1905382 positive regulation of snRNA transcription by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XI01-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63228-1", "uniprot_id": [ { "id": "GMFB_RAT", "url": "https://www.uniprot.org/uniprot/Q63228", "type": "external" } ], "mass": 16736.0, "length": 142, "protein_name": "Glia maturation factor beta", "gene_name": "Gmfb", "organism": "Rat", "refseq_name": "glia maturation factor beta", "refseq_ac": [ { "id": "NP_112294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112294", "type": "external" } ], "gene_names_uniprotkb": "Gmfb", "gene_names_refseq": "Gmfb", "protein_names_uniprotkb": "Glia maturation factor beta; GMF-beta", "protein_names_refseq": "DNA for thyroid hormone receptor binding site (276bp); GMF-beta; glia maturation factor beta", "tax_id": 10116, "disease": "", "pathway": " (rno:81661)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "30191459;37121966;37904673;8436977", "class_list": "", "function": "GMFB/AKT/TGF-beta3 in Muller cells mediated early retinal degeneration in a streptozotocin-induced rat diabetes model., [RefSeq, PubMed]; Glia maturation factor beta deficiency protects against diabetic osteoporosis by suppressing osteoclast hyperactivity., [RefSeq, PubMed]; This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This study demonstrated that GMFB is up-regulated in astrocytes after Acute Cerebral Ischemia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008083 growth factor activity;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0071846 actin filament debranching;GO:0007612 learning;GO:0007626 locomotory behavior;GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63228-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52953-1", "uniprot_id": [ { "id": "MSX2_RAT", "url": "https://www.uniprot.org/uniprot/P52953", "type": "external" } ], "mass": 15839.0, "length": 139, "protein_name": "Homeobox protein MSX-2", "gene_name": "Msx2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Msx2; Msx-2", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein MSX-2; Homeobox protein Hox-8-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "parietal foramina (Disease Ontology:DOID:0060285); craniosynostosis 2 (Disease Ontology:DOID:0061009); hypertension (Disease Ontology:DOID:10763); craniosynostosis (Disease Ontology:DOID:2340)", "pathway": " (rno:25483)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7877617", "class_list": "", "function": "Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0005667 transcription regulator complex;GO:0005634 nucleus", "go_biological_process": "GO:0060364 frontal suture morphogenesis;GO:0045617 negative regulation of keratinocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P52953-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55248-1", "uniprot_id": [ { "id": "SH_RAT", "url": "https://www.uniprot.org/uniprot/P55248", "type": "external" } ], "mass": 11792.0, "length": 106, "protein_name": "Putative protein SH", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative protein SH; SH-4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3547652", "class_list": "", "function": "May be involved with the regulation of GNRH gene expression. It is not known if this protein is transcribed., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005183 gonadotropin hormone-releasing hormone activity", "go_cellular_component": "GO:1990008 neurosecretory vesicle;GO:0005615 extracellular space;GO:0005798 Golgi-associated vesicle;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:1990637 response to prolactin;GO:0033087 negative regulation of immature T cell proliferation;GO:2000354 regulation of ovarian follicle development;GO:0032496 response to lipopolysaccharide;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P55248-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56499-1", "uniprot_id": [ { "id": "UCP3_RAT", "url": "https://www.uniprot.org/uniprot/P56499", "type": "external" } ], "mass": 34015.0, "length": 308, "protein_name": "Putative mitochondrial transporter UCP3", "gene_name": "Ucp3", "organism": "Rat", "refseq_name": "putative mitochondrial transporter UCP3", "refseq_ac": [ { "id": "NP_037299", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037299", "type": "external" } ], "gene_names_uniprotkb": "Ucp3; Slc25a9", "gene_names_refseq": "Ucp3", "protein_names_uniprotkb": "Putative mitochondrial transporter UCP3; Solute carrier family 25 member 9; UCP 3; Uncoupling protein-3", "protein_names_refseq": "UCP 3; Uncoupling protein 3, mitochondrial; mitochondrial uncoupling protein 3; putative mitochondrial transporter UCP3; solute carrier family 25 member 9; uncoupling protein 3 (mitochondrial, proton carrier)", "tax_id": 10116, "disease": "hypocholesteremia (Disease Ontology:DOID:0061212); hypertension (Disease Ontology:DOID:10763); prediabetes syndrome (Disease Ontology:DOID:11716); hypothyroidism (Disease Ontology:DOID:1459); coronary restenosis (Disease Ontology:DOID:4247); congestive heart failure (Disease Ontology:DOID:6000); hyperthyroidism (Disease Ontology:DOID:7998); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:25708); (R-RNO-167826)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "23084644;24950599;25944715;29393594;30374710;9414126;9506477;9725803", "class_list": "", "function": "Based on Ucp3 content, a decrease in oxidative capacity and proton leak in intermyofibrillar and subsarcolemmal mitochondria could induce a decline in energy expenditure and thus contribute to the reduced resting metabolic rate found in old rats. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that UCP3 expression, energy metabolism, and uptake/beta-oxidation of free fatty acids in skeletal muscle can be regulated by dietary components; here, ursolic acid, a dietary triterpenoid, has anti-obesity effects., [RefSeq, PubMed]; Endurance training blocked the high-sugar diet induced up-regulation of UCP1 expression in interscapular brown adipose tissue, whereas it up-regulated the expression of Ucp3 mRNA in muscle., [RefSeq, PubMed]; Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism. Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter from the mitochondrial intermembrane space into the matrix, causing proton leaks through the inner mitochondrial membrane, thereby uncoupling mitochondrial membrane potential generation from ATP synthesis. However, this function is controversial and uncoupling may not be the function, or at least not the main function, but rather a consequence of more conventional metabolite transporter activity., [UniProtKB, UniProtKB]; We demonstrated that normal cardiac UCP3 levels are essential to recovery of long-chain fatty acid oxidation, mitochondrial respiratory capacity, and contractile function following cardiac ischemia/reperfusion Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015078 proton transmembrane transporter activity;GO:0017077 oxidative phosphorylation uncoupler activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:1901373 lipid hydroperoxide transport;GO:0000303 response to superoxide;GO:0006631 fatty acid metabolic process;GO:0007584 response to nutrient;GO:0009409 response to cold", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P56499-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56500-1", "uniprot_id": [ { "id": "UCP2_RAT", "url": "https://www.uniprot.org/uniprot/P56500", "type": "external" } ], "mass": 33377.0, "length": 309, "protein_name": "Dicarboxylate carrier UCP2", "gene_name": "Ucp2", "organism": "Rat", "refseq_name": "dicarboxylate carrier UCP2", "refseq_ac": [ { "id": "NP_062227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062227", "type": "external" } ], "gene_names_uniprotkb": "Ucp2; Slc25a8", "gene_names_refseq": "Ucp2", "protein_names_uniprotkb": "Dicarboxylate carrier UCP2; Mitochondrial uncoupling protein 2; Solute carrier family 25 member 8; UCP 2", "protein_names_refseq": "UCP 2; Uncoupling protein 2, mitochondrial; dicarboxylate carrier SLC25A8; dicarboxylate carrier UCP2; mitochondrial uncoupling protein 2; solute carrier family 25 member 8; uncoupling protein 2 (mitochondrial, proton carrier)", "tax_id": 10116, "disease": "polycystic liver disease (Disease Ontology:DOID:0050770); stroke (Disease Ontology:DOID:0051061); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hypertension (Disease Ontology:DOID:10763); Huntington's disease (Disease Ontology:DOID:12858); obstructive jaundice (Disease Ontology:DOID:13603); hypothyroidism (Disease Ontology:DOID:1459); transient cerebral ischemia (Disease Ontology:DOID:224); carotid artery disease (Disease Ontology:DOID:3407); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:54315); (R-RNO-167826)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "34625529;35771638;38134189;38301949;39049639;9414126;9512646", "class_list": "", "function": "An interplay between UCP2 and ROS protects cells from high-salt-induced injury through autophagy stimulation. Publication Status: Online-Only, [RefSeq, PubMed]; Antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis, glutaminolysis and glutathione-dependent redox balance. Continuous export of oxaloacetate and related four-carbon dicarboxylates from mitochondrial matrix into the cytosol negatively regulates the oxidation of acetyl-CoA substrates via the Krebs cycle lowering the ATP/ADP ratio and reactive oxygen species (ROS) production (By similarity). May mediate inducible proton entry into the mitochondrial matrix affecting ATP turnover as a protection mechanism against oxidative stress. The proton currents are most likely associated with fatty acid flipping across the inner membrane of mitochondria in a metabolic process regulated by free fatty acids and purine nucleotides (By similarity). Regulates the use of glucose as a source of energy. Required for glucose-induced DRP1-dependent mitochondrial fission and neuron activation in the ventromedial nucleus of the hypothalamus (VMH). This mitochondrial adaptation mechanism modulates the VMH pool of glucose-excited neurons with an impact on systemic glucose homeostasis. Regulates ROS levels and metabolic reprogramming of macrophages during the resolution phase of inflammation. Attenuates ROS production in response to IL33 to preserve the integrity of the Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity). Can unidirectionally transport anions including L-malate, L-aspartate, phosphate and chloride ions (By similarity). Does not mediate adaptive thermogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; GPER activation attenuates cardiac dysfunction by upregulating the SIRT1/3-AMPK-UCP2 pathway in postmenopausal diabetic rats. Publication Status: Online-Only, [RefSeq, PubMed]; The role of uncoupling protein 2 in experimental periodontitis-associated renal injury in rats., [RefSeq, PubMed]; UCP2 modulates cardiomyocyte cell cycle activity, acetyl-CoA, and histone acetylation in response to moderate hypoxia. Publication Status: Online-Only, [RefSeq, PubMed]; UCP2 overexpression activates SIRT3 to regulate oxidative stress and mitochondrial dynamics induced by myocardial injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70178;O88183;Q6GST1", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0015297 antiporter activity;GO:0019003 GDP binding;GO:0015078 proton transmembrane transporter activity;GO:0015108 chloride transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0000303 response to superoxide;GO:0006839 mitochondrial transport;GO:0009409 response to cold;GO:0032869 cellular response to insulin stimulus;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P56500-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56572-1", "uniprot_id": [ { "id": "UH03_RAT", "url": "https://www.uniprot.org/uniprot/P56572", "type": "external" } ], "mass": 1255.0, "length": 12, "protein_name": "Unknown protein from spot P3 of 2D-PAGE of heart tissue", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Unknown protein from spot P3 of 2D-PAGE of heart tissue", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, 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"uniprot_id": [ { "id": "UH09_RAT", "url": "https://www.uniprot.org/uniprot/P56575", "type": "external" } ], "mass": 1029.0, "length": 8, "protein_name": "Unknown protein from spot P9 of 2D-PAGE of heart tissue", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Unknown protein from spot P9 of 2D-PAGE of heart tissue", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, 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"0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56576-1", "uniprot_id": [ { "id": "UH11_RAT", "url": "https://www.uniprot.org/uniprot/P56576", "type": "external" } ], "mass": 775.0, "length": 7, "protein_name": "Unknown protein from spot P11 of 2D-PAGE of heart tissue", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Unknown protein from spot P11 of 2D-PAGE of heart tissue", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P56576-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59692-1", "uniprot_id": [ { "id": "SIVA_RAT", "url": "https://www.uniprot.org/uniprot/P59692", "type": "external" } ], "mass": 18899.0, "length": 177, "protein_name": "Apoptosis regulatory protein Siva", "gene_name": "Siva1", "organism": "Rat", "refseq_name": "apoptosis regulatory protein Siva", "refseq_ac": [ { "id": "NP_001381466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001381466", "type": "external" } ], "gene_names_uniprotkb": "Siva1; Siva", "gene_names_refseq": "Siva1; Siva", "protein_names_uniprotkb": "Apoptosis regulatory protein Siva; CD27-binding protein; CD27BP", "protein_names_refseq": "CD27-binding protein; CD27BP; apoptosis regulatory protein Siva", "tax_id": 10116, "disease": "", "pathway": " (rno:362791)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19251341;9853261", "class_list": "", "function": "Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis (By similarity)., [UniProtKB]; This study demonistrated that AIF more abundantly expressed in striatum than in the other two brain regions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001618 virus receptor activity;GO:0005175 CD27 receptor binding;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0097191 extrinsic apoptotic signaling pathway;GO:0097193 intrinsic apoptotic signaling pathway;GO:0006924 activation-induced cell death of T cells", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P59692-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59926-1", "uniprot_id": [ { "id": "SYT15_RAT", "url": "https://www.uniprot.org/uniprot/P59926", "type": "external" } ], "mass": 47592.0, "length": 422, "protein_name": "Synaptotagmin-15", "gene_name": "Syt15", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Syt15; Sytxv", "gene_names_refseq": "", "protein_names_uniprotkb": "Synaptotagmin-15; Synaptotagmin XV; SytXV", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:306285)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12788067", "class_list": "", "function": "May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005544 calcium-dependent phospholipid binding;GO:0000149 SNARE binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0070382 exocytic vesicle", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0017158 regulation of calcium ion-dependent exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P59926-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61808-1", "uniprot_id": [ { "id": "SNN_RAT", "url": "https://www.uniprot.org/uniprot/P61808", "type": "external" } ], "mass": 9501.0, "length": 88, "protein_name": "Stannin", "gene_name": "Snn", "organism": "Rat", "refseq_name": "stannin", "refseq_ac": [ { "id": "NP_001029255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029255", "type": "external" } ], "gene_names_uniprotkb": "Snn", "gene_names_refseq": "Snn", "protein_names_uniprotkb": "Stannin", "protein_names_refseq": "stannin", "tax_id": 10116, "disease": "", "pathway": " (rno:29140)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15923056;1635553;22673903;9413842", "class_list": "", "function": "Plays a role in the toxic effects of organotins (PubMed:1635553). Plays a role in endosomal maturation (By similarity)., [UniProtKB, UniProtKB, PubMed]; Together, these findings indicate a role of Stannin in modulation of MAPK signaling pathways through its interactions with 14-3-3zeta, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88369;Q498Q9", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P61808-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61943-1", "uniprot_id": [ { "id": "SIA10_RAT", "url": "https://www.uniprot.org/uniprot/P61943", "type": "external" } ], "mass": 38145.0, "length": 331, "protein_name": "Type 2 lactosamine alpha-2,3-sialyltransferase", "gene_name": "St3gal6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "St3gal6; Siat10", "gene_names_refseq": "", "protein_names_uniprotkb": "Type 2 lactosamine alpha-2,3-sialyltransferase; 2.4.3.6; CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI; ST3Gal VI; ST3GalVI; Sialyltransferase 10", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:304023); (R-RNO-2022854); (R-RNO-4085001); (R-RNO-9037629)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Transfers the sialyl residue from CMP-N-acetyl-beta-neuraminate to the terminal galactose residue on sugar chains of glycoproteins and glycolipids. Its alpha-2,3-sialyltransferase activity is specific toward type II glycan chains (Galbeta1-4GlcNAc) on glycoproteins and glycolipids such as neolactosides nLc4Cer and nLc6Cer, whose sialyl-products serve as precursors for the Lewis X antigen. Critically involved in the synthesis of functional selectin ligands needed for neutrophil recruitment during inflammation and lymphocyte homing to the lymph nodes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.2", "type": "external" }, { "id": "2.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.4", "type": "external" }, { "id": "3.6.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.59", "type": "external" }, { "id": "2.4.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.6", "type": "external" }, { "id": "2.4.3.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.9", "type": "external" } ], "go_molecular_function": "GO:0008373 sialyltransferase activity;GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0009247 glycolipid biosynthetic process;GO:0071354 cellular response to interleukin-6", "synthesized_glycan_count": 2417, "hit_score": 0.1, "record_id": "P61943-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62819-1", "uniprot_id": [ { "id": "S10A3_RAT", "url": "https://www.uniprot.org/uniprot/P62819", "type": "external" } ], "mass": 11747.0, "length": 101, "protein_name": "Protein S100-A3", "gene_name": "S100a3", "organism": "Rat", "refseq_name": "protein S100-A3", "refseq_ac": [ { "id": "NP_446133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446133", "type": "external" } ], "gene_names_uniprotkb": "S100a3", "gene_names_refseq": "S100a3", "protein_names_uniprotkb": "Protein S100-A3; Protein S-100E; S100 calcium-binding protein A3", "protein_names_refseq": "protein S100-A3", "tax_id": 10116, "disease": "", "pathway": " (rno:114216)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P56566", "ec_number_list": [], "go_molecular_function": "GO:0046914 transition metal ion binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P62819-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63029-1", "uniprot_id": [ { "id": "TCTP_RAT", "url": "https://www.uniprot.org/uniprot/P63029", "type": "external" } ], "mass": 19462.0, "length": 172, "protein_name": "Translationally-controlled tumor protein", "gene_name": "Tpt1", "organism": "Rat", "refseq_name": "translationally-controlled tumor protein", "refseq_ac": [ { "id": "NP_446319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446319", "type": "external" } ], "gene_names_uniprotkb": "Tpt1; Trt", "gene_names_refseq": "Tpt1", "protein_names_uniprotkb": "Translationally-controlled tumor protein; Lens epithelial protein; TCTP", "protein_names_refseq": "TCTP; lens epithelial protein; translationally-controlled tumor protein", "tax_id": 10116, "disease": "", "pathway": " (rno:116646)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11156187;11368327;26266488;27783042;29676587;31320615;32174219", "class_list": "", "function": "After acute spinal cord injury, TCTP in astrocytes gradually increased, peaking at day 3 and returning to basal levels by day 14. TCTP knockdown reduced astrocyte migration and proliferation., [RefSeq, PubMed]; Downregulation of transcription factor TCTP elevates microRNA-200a expression to restrain Myt1L expression, thereby improving neurobehavior and oxidative stress injury in cerebral palsy rats., [RefSeq, PubMed]; Involved in calcium binding and microtubule stabilization (By similarity). Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (By similarity)., [UniProtKB, UniProtKB]; TCTP has a pivotal role in cardiomyocyte survival, at least in part through a Bnip3-dependent mechanism. Publication Status: Online-Only, [RefSeq, PubMed]; These data suggest an important role for TCTP in regulating the critical vascular cell phenotypes that have been implicated in the pathobiology of Pulmonary arterial hypertension., [RefSeq, PubMed]; Tumor protein translationally-controlled -induced dopamine release from neuronal PC12 cells was modulated by a Ca(2+)-independent mechanism that involved PLA in the process, suggesting the regulatory role of TCTP in the neuronal functions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P14701", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009615 response to virus;GO:0019827 stem cell population maintenance;GO:2000384 negative regulation of ectoderm development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P63029-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63249-1", "uniprot_id": [ { "id": "IPKA_RAT", "url": "https://www.uniprot.org/uniprot/P63249", "type": "external" } ], "mass": 7960.0, "length": 76, "protein_name": "cAMP-dependent protein kinase inhibitor alpha", "gene_name": "Pkia", "organism": "Rat", "refseq_name": "cAMP-dependent protein kinase inhibitor alpha", "refseq_ac": [ { "id": "NP_446224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446224", "type": "external" } ], "gene_names_uniprotkb": "Pkia", "gene_names_refseq": "Pkia", "protein_names_uniprotkb": "cAMP-dependent protein kinase inhibitor alpha; PKI-alpha; cAMP-dependent protein kinase inhibitor, muscle/brain isoform", "protein_names_refseq": "PKI-alpha; cAMP-dependent protein kinase inhibitor alpha; protein kinase (cAMP-dependent, catalytic) inhibitor alpha; protein kinase inhibitor, alpha", "tax_id": 10116, "disease": "", "pathway": " (rno:114906)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1491692", "class_list": "", "function": "Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P27776", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:2000480 negative regulation of cAMP-dependent protein kinase activity;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006469 negative regulation of protein kinase activity;GO:0010389 regulation of G2/M transition of mitotic cell cycle;GO:0043086 negative regulation of catalytic activity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P63249-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63301-1", "uniprot_id": [ { "id": "SELW_RAT", "url": "https://www.uniprot.org/uniprot/P63301", "type": "external" } ], "mass": 9687.0, "length": 88, "protein_name": "Selenoprotein W", "gene_name": "Selenow", "organism": "Rat", "refseq_name": "selenoprotein W", "refseq_ac": [ { "id": "NP_037159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037159", "type": "external" } ], "gene_names_uniprotkb": "Selenow; Selw; Sepw1", "gene_names_refseq": "SelW; Selenow; Sepw1", "protein_names_uniprotkb": "Selenoprotein W; SelW", "protein_names_refseq": "selenoprotein W, 1; selenoprotein W, muscle 1; selenoprotein W", "tax_id": 10116, "disease": "hereditary systemic amyloidosis 2 (Disease Ontology:DOID:0050636); brain small vessel disease (Disease Ontology:DOID:0112313); keratoconus (Disease Ontology:DOID:10126); disseminated intravascular coagulation (Disease Ontology:DOID:11247); thrombocytopenia (Disease Ontology:DOID:1588); congenital afibrinogenemia (Disease Ontology:DOID:2236); brain ischemia (Disease Ontology:DOID:2316); thrombophilia (Disease Ontology:DOID:2452); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); vascular hemostatic disease (Disease Ontology:DOID:484); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); pulmonary emphysema (Disease Ontology:DOID:9675); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:25545)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15055543;15337603;20956524;7568010;7896009;8349599;8576706", "class_list": "", "function": "Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Se-W plays an important role as an antioxidant in the developing brain and embryo, [RefSeq, PubMed]; SelW gene was activated by the binding of MyoD to a specific E-box during early skeletal muscle differentiation., [RefSeq, PubMed]; The SeW gene may be a target for Sp1 whose binding to various regulatory sequences of the SeW promoter may activate or repress the transcription of SeW, [RefSeq, PubMed]; This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A pseudogene of this locus has been identified on chromosome 10. [provided by RefSeq, Aug 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35965;P49904;Q9JIC2", "ec_number_list": [], "go_molecular_function": "GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0030218 erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P63301-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P69209-1", "uniprot_id": [ { "id": "MORN_RAT", "url": "https://www.uniprot.org/uniprot/P69209", "type": "external" } ], "mass": 1142.0, "length": 11, "protein_name": "Morphogenetic neuropeptide", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Morphogenetic neuropeptide; HA; Head activator", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "2583101;7290191;7297679", "class_list": "", "function": "Stimulates the proliferation of neural cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P01163", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity", "go_cellular_component": "", "go_biological_process": "GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P69209-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70502-1", "uniprot_id": [ { "id": "SO1A3_RAT", "url": "https://www.uniprot.org/uniprot/P70502", "type": "external" } ], "mass": 73817.0, "length": 670, "protein_name": "Solute carrier organic anion transporter family member 1A3", "gene_name": "Slco1a3", "organism": "Rat", "refseq_name": "solute carrier organic anion transporter family member 1A3", "refseq_ac": [ { "id": "NP_110464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110464", "type": "external" } ], "gene_names_uniprotkb": "Slco1a3; Oatp1a3; Slc21a4", "gene_names_refseq": "OAT-K1; OAT-K2; Slc21a4; Slco1a3; Slco1a8; rOAT-K11; rOAT-K13; rOAT-K14; rOAT-K1; rOAT-K2; rOAT-K3; rOAT-K5; rOAT-K6; rOAT-K7; rOAT-K8; rOAT-K9", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 1A3; OAT-K1; OAT-K2; Sodium-independent organic anion transporter K1; Solute carrier family 21 member 4; rOAT-K", "protein_names_refseq": "kidney specific organic anion transporter; rOAT-K; sodium-independent organic anion transporter K1; solute carrier family 21 member 4; solute carrier organic anion transporter family member 1A3", "tax_id": 10116, "disease": "", "pathway": " (rno:80899)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10101033;12180133;8702823", "class_list": "", "function": "Mediates the Na(+)-independent transport of organic anions such as methotrexate, taurocholate, folate and prostaglandin E2. May contribute to renal secretion and/or reabsorption of hydrophobic anionic compounds. Mediates renal clearance of methotrexate from the blood., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8R008;Q8R4J0;Q8R4J1;Q8R4J2;Q8R4J3;Q8R4J4;Q8R4J5;Q8R4J6;Q8R4J7;Q8R4J8;Q8R4J9;Q8R4K0;Q8R4K1;Q9WTM0", "ec_number_list": [], "go_molecular_function": "GO:0015125 bile acid transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0015721 bile acid and bile salt transport;GO:0043252 sodium-independent organic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P70502-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70545-1", "uniprot_id": [ { "id": "S13A2_RAT", "url": "https://www.uniprot.org/uniprot/P70545", "type": "external" } ], "mass": 64143.0, "length": 587, "protein_name": "Solute carrier family 13 member 2", "gene_name": "Slc13a2", "organism": "Rat", "refseq_name": "solute carrier family 13 member 2", "refseq_ac": [ { "id": "NP_113934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113934", "type": "external" } ], "gene_names_uniprotkb": "Slc13a2; Nadc1; Sdct1", "gene_names_refseq": "Nadc1; Slc13a2; mucin", "protein_names_uniprotkb": "Solute carrier family 13 member 2; Intestinal sodium/dicarboxylate cotransporter; Na(+)/dicarboxylate cotransporter 1; NaDC-1", "protein_names_refseq": "Na(+)/dicarboxylate cotransporter 1; intestinal sodium/dicarboxylate cotransporter; naDC-1; sodium-dependent dicarboxylate transporter; solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2; solute carrier family 13 member 2", "tax_id": 10116, "disease": "alcohol-related neurodevelopmental disorder (Disease Ontology:DOID:0050667); Kohlschutter-Tonz syndrome (Disease Ontology:DOID:0111668); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:65202); (R-RNO-9955298)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "20877231;24652587;25209509;26269671;29453360;30140954;8950177;9691021;9694847", "class_list": "", "function": "Cholestasis induced by common bile duct ligation in the rat induces upregulation of NaDC1 in kidneys., [RefSeq, PubMed]; ITF can improve cytomorphosis ability for promoting cell migration with limited effect on cell proliferation, which can be enhanced with addition of mucin. The main mechanism of ITF in maintaining intestinal mucosal barrier may be attributed to acceleration of cell migration. Erratum:[Sci Rep. 2020 Jul 24;10(1):12741. doi: 10.1038/s41598-020-69648-x. PMID: 32704055] Publication Status: Online-Only, [RefSeq, PubMed]; Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule (PubMed:9691021, PubMed:9694847). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:9691021, PubMed:9694847). Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood (PubMed:9694847). Has a critical role in renal dicarboxylate transport (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; NaDC1 was predominantly located in discrete apical membrane or subapical areas in proximal kidney tubules., [RefSeq, PubMed]; The renal expression of NaDC1 was decreased in the mouse model of obstructive nephropathy. The urinary excretion of NaDC1 increased after short times of ureteral obstruction., [RefSeq, PubMed]; These findings may explain the fructo-oligosaccharides-induced early elevation of IgA and mucin, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35055", "ec_number_list": [], "go_molecular_function": "GO:0015139 alpha-ketoglutarate transmembrane transporter activity;GO:0017153 sodium:dicarboxylate symporter activity;GO:0015141 succinate transmembrane transporter activity;GO:0015138 fumarate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0071285 cellular response to lithium ion;GO:0015742 alpha-ketoglutarate transport;GO:0071422 succinate transmembrane transport;GO:0015741 fumarate transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P70545-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000010000000.010.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70551-1", "uniprot_id": [ { "id": "IOD2_RAT", "url": "https://www.uniprot.org/uniprot/P70551", "type": "external" } ], "mass": 29871.0, "length": 266, "protein_name": "Type II iodothyronine deiodinase", "gene_name": "Dio2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dio2; Itdi2; Txdi2", "gene_names_refseq": "", "protein_names_uniprotkb": "Type II iodothyronine deiodinase; 1.21.99.4; 5DII; DIOII; Type 2 DI; Type-II 5'-deiodinase", "protein_names_refseq": "", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); hypothyroidism (Disease Ontology:DOID:1459); glucose metabolism disease (Disease Ontology:DOID:4194)", "pathway": " (rno:65162); (R-RNO-350864)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "19103603;8755651;9178860;9709916", "class_list": "", "function": "Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:9709916). Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD) (By similarity). Catalyzes the deiodination of 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) via ORD (PubMed:8755651). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine and 3',5'- diiodothyronamine (By similarity)., [UniProtKB, PubMed, UniProtKB]; Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70179", "ec_number_list": [ { "id": "1.21.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.21.99.3", "type": "external" }, { "id": "1.21.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.21.99.4", "type": "external" } ], "go_molecular_function": "GO:0033798 thyroxine 5-deiodinase activity;GO:0031625 ubiquitin protein ligase binding;GO:0004800 thyroxine 5'-deiodinase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0042404 thyroid hormone catabolic process;GO:0006629 lipid metabolic process;GO:0032496 response to lipopolysaccharide;GO:0050873 brown fat cell differentiation;GO:0042446 hormone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70551-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70628-1", "uniprot_id": [ { "id": "IMPG2_RAT", "url": "https://www.uniprot.org/uniprot/P70628", "type": "external" } ], "mass": 137547.0, "length": 1241, "protein_name": "Interphotoreceptor matrix proteoglycan 2", "gene_name": "Impg2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Impg2", "gene_names_refseq": "", "protein_names_uniprotkb": "Interphotoreceptor matrix proteoglycan 2; PG10.2; Sialoprotein associated with cones and rods proteoglycan; Spacrcan", "protein_names_refseq": "", "tax_id": 10116, "disease": "vitelliform macular dystrophy (Disease Ontology:DOID:0050661); retinitis pigmentosa 56 (Disease Ontology:DOID:0110371)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "11406817;8883960", "class_list": "", "function": "Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin., [UniProtKB, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 7, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0033165 interphotoreceptor matrix;GO:0043235 receptor complex", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0030198 extracellular matrix organization;GO:0007601 visual perception;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P70628-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70712-1", "uniprot_id": [ { "id": "KYNU_RAT", "url": "https://www.uniprot.org/uniprot/P70712", "type": "external" } ], "mass": 52470.0, "length": 464, "protein_name": "Kynureninase", "gene_name": "Kynu", "organism": "Rat", "refseq_name": "kynureninase", "refseq_ac": [ { "id": "NP_446354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446354", "type": "external" } ], "gene_names_uniprotkb": "Kynu; KYNU", "gene_names_refseq": "Kynu", "protein_names_uniprotkb": "Kynureninase; 3.7.1.3; L-kynurenine hydrolase", "protein_names_refseq": "L-kynurenine hydrolase; kynureninase", "tax_id": 10116, "disease": "hydroxykynureninuria (Disease Ontology:DOID:0112257); hypertension (Disease Ontology:DOID:10763)", "pathway": " (rno:116682); (R-RNO-71240)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12379607;22673903;29393594;7578221;8706755;9180257", "class_list": "", "function": "Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity., [UniProtKB, PubMed, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Kynurenine aminotransferase is expressed in the neurons of the transient subplate zone during prenatal development of the cerebral cortex and may play a role in regulating programmed neuronal cell death., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q68G25;Q7M0D0;Q9QW90", "ec_number_list": [ { "id": "3.7.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.7.1.3", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042803 protein homodimerization activity;GO:0030429 kynureninase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0097053 L-kynurenine catabolic process;GO:0006569 L-tryptophan catabolic process;GO:0019441 L-tryptophan catabolic process to kynurenine;GO:0009435 NAD+ biosynthetic process;GO:0019805 quinolinate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70712-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80968-1", "uniprot_id": [ { "id": "SMBP_RAT", "url": "https://www.uniprot.org/uniprot/P80968", "type": "external" } ], "mass": 3068.0, "length": 24, "protein_name": "SM-11044-binding protein", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "SM-11044-binding protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9261134", "class_list": "", "function": "May mediate relaxation of depolarized colon tonus. It binds iodocyanopindolol and SM-11044., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P80968-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81563-1", "uniprot_id": [ { "id": "MMP1_RAT", "url": "https://www.uniprot.org/uniprot/P81563", "type": "external" } ], "mass": 1787.0, "length": 15, "protein_name": "Interstitial collagenase", "gene_name": "Mmp1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mmp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Interstitial collagenase; 3.4.24.7; Fibroblast collagenase; MMP-1; Matrix metalloproteinase-1; Myocardial collagenase", "protein_names_refseq": "", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); glomerulosclerosis (Disease Ontology:DOID:0050851); renal fibrosis (Disease Ontology:DOID:0050855); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); scoliosis (Disease Ontology:DOID:0060249); thrombosis (Disease Ontology:DOID:0060903); COVID-19 (Disease Ontology:DOID:0080600); immunoglobulin light chain amyloidosis (Disease Ontology:DOID:0080933); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); carotid stenosis (Disease Ontology:DOID:13001); lung cancer (Disease Ontology:DOID:1324); thoracic aortic aneurysm (Disease Ontology:DOID:14004); breast cancer (Disease Ontology:DOID:1612); aortic valve stenosis (Disease Ontology:DOID:1712); atherosclerosis (Disease Ontology:DOID:1936); obstructive lung disease (Disease Ontology:DOID:2320); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); esophagus adenocarcinoma (Disease Ontology:DOID:4914); epidermolysis bullosa dystrophica (Disease Ontology:DOID:4959); liver cirrhosis (Disease Ontology:DOID:5082); stomach carcinoma (Disease Ontology:DOID:5517); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); varicose veins (Disease Ontology:DOID:799); periodontitis (Disease Ontology:DOID:824); osteoarthritis (Disease Ontology:DOID:8398); localized scleroderma (Disease Ontology:DOID:8472); ulcerative colitis (Disease Ontology:DOID:8577); intermediate coronary syndrome (Disease Ontology:DOID:8805); skin melanoma (Disease Ontology:DOID:8923); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); degenerative disc disease (Disease Ontology:DOID:90); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074); Barrett's esophagus (Disease Ontology:DOID:9206); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675); tendinitis (Disease Ontology:DOID:971)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8605638", "class_list": "", "function": "Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. May play a role in the deterioration of the heart wall extracellular matrix proteins during the onset of dilated cardiomyopathy., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 58, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0071680 response to indole-3-methanol;GO:0006508 proteolysis;GO:0071466 cellular response to xenobiotic stimulus;GO:0071222 cellular response to lipopolysaccharide;GO:0009612 response to mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P81563-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81795-1", "uniprot_id": [ { "id": "IF2G_RAT", "url": "https://www.uniprot.org/uniprot/P81795", "type": "external" } ], "mass": 51079.0, "length": 472, "protein_name": "Eukaryotic translation initiation factor 2 subunit 3, X-linked", "gene_name": "Eif2s3", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 2 subunit 3, X-linked", "refseq_ac": [ { "id": "NP_001094012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094012", "type": "external" } ], "gene_names_uniprotkb": "Eif2s3; Eif2g; Eif2s3x", "gene_names_refseq": "Eif2g; Eif2s3x; Eif2s3; PP42", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2 subunit 3, X-linked; 3.6.5.3; Eukaryotic translation initiation factor 2 subunit gamma, X-linked; PP42; eIF2-gamma X; eIF2-gamma", "protein_names_refseq": "eIF-2-gamma X; eIF2-gamma X; eIF2-gamma; eukaryotic translation initiation factor 2 subunit 3, X-linked; eukaryotic translation initiation factor 2 subunit gamma, X-linked; eukaryotic translation initiation factor 2, subunit 3 gamma; eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked", "tax_id": 10116, "disease": "MEHMO syndrome (Disease Ontology:DOID:0060801); leukodystrophy (Disease Ontology:DOID:10579); glucose metabolism disease (Disease Ontology:DOID:4194); hypopituitarism (Disease Ontology:DOID:9406)", "pathway": " (rno:299027); (R-RNO-156827); (R-RNO-381042); (R-RNO-382556); (R-RNO-72649); (R-RNO-72695); (R-RNO-72702); (R-RNO-72731); (R-RNO-9840373)", "pathway_count": 9, "publication_count": 4, "publication_id_list": "25548914;38843836;8780732;9736774", "class_list": "", "function": "Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0BN96;B2RYH8;Q5BJX8", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008135 translation factor activity, RNA binding;GO:0003743 translation initiation factor activity;GO:1990856 methionyl-initiator methionine tRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0005850 eukaryotic translation initiation factor 2 complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0006413 translational initiation;GO:0001731 formation of translation preinitiation complex", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P81795-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81828-1", "uniprot_id": [ { "id": "UP2_RAT", "url": "https://www.uniprot.org/uniprot/P81828", "type": "external" } ], "mass": 11068.0, "length": 101, "protein_name": "Urinary protein 2", "gene_name": "", "organism": "Rat", "refseq_name": "urinary protein 2 precursor", "refseq_ac": [ { "id": "NP_001395991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001395991", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "Rup-3; Rup2l1; Rup2l2; UP-2; rUP-2", "protein_names_uniprotkb": "Urinary protein 2; UP-2; rUP-2", "protein_names_refseq": "urinary protein 2 like 1; urinary protein 2 precursor; urinary protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:103693047)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11565799;11840564", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001848 complement binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0001971 negative regulation of activation of membrane attack complex", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P81828-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83888-1", "uniprot_id": [ { "id": "TBG1_RAT", "url": "https://www.uniprot.org/uniprot/P83888", "type": "external" } ], "mass": 51101.0, "length": 451, "protein_name": "Tubulin gamma-1 chain", "gene_name": "Tubg1", "organism": "Rat", "refseq_name": "tubulin gamma-1 chain", "refseq_ac": [ { "id": "NP_665721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665721", "type": "external" } ], "gene_names_uniprotkb": "Tubg1; Tubg", "gene_names_refseq": "Tubg1", "protein_names_uniprotkb": "Tubulin gamma-1 chain; GCP-1; Gamma-1-tubulin; Gamma-tubulin complex component 1", "protein_names_refseq": "GCP-1; gamma-1-tubulin; gamma-tubulin complex component 1; tubulin gamma-1 chain", "tax_id": 10116, "disease": "muscular disease (Disease Ontology:DOID:0080000); complex cortical dysplasia with other brain malformations 4 (Disease Ontology:DOID:0090138); inclusion body myositis (Disease Ontology:DOID:3429)", "pathway": " (rno:252921); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-8854518)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "10470852;12672672;12672673;15048127;29393594", "class_list": "", "function": "Gamma-tubulin overexpression caused redistribution of Sertoli cell microtubule networks, and a gamma-tubulin-enhanced green fluorescent protein fusion protein localized to the site of elongate spermatid head attachment to the seminiferous epithelium., [RefSeq, PubMed]; Gamma-tubulin overexpression disrupts the Sertoli cell microtubule network,leads to gross disorganization of the seminiferous epithelium, inducing retention of spermatids and residual bodies; and causes germ cell apoptosis., [RefSeq, PubMed]; Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (By similarity). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (By similarity). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (By similarity). Plays a role in sperm morphological development during late stage spermiogenesis, particularly the anchoring of the sperm head to the tail (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z310", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0140490 microtubule nucleator activity", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007020 microtubule nucleation;GO:0007052 mitotic spindle organization;GO:0000070 mitotic sister chromatid segregation;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P83888-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84551-1", "uniprot_id": [ { "id": "SKOR1_RAT", "url": "https://www.uniprot.org/uniprot/P84551", "type": "external" } ], "mass": 100234.0, "length": 964, "protein_name": "SKI family transcriptional corepressor 1", "gene_name": "Skor1", "organism": "Rat", "refseq_name": "SKI family transcriptional corepressor 1 isoform 1", "refseq_ac": [ { "id": "NP_001363881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001363881", "type": "external" } ], "gene_names_uniprotkb": "Skor1; Lbxcor1", "gene_names_refseq": "Lbxcor1; RGD1307687; Skor1", "protein_names_uniprotkb": "SKI family transcriptional corepressor 1; Ladybird homeobox corepressor 1", "protein_names_refseq": "SKI family transcriptional corepressor 1 isoform 1; ladybird homeobox 1 homolog corepressor 1; ladybird homeobox corepressor 1", "tax_id": 10116, "disease": "nervous system disease (Disease Ontology:DOID:863)", "pathway": " (rno:315748)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits BMP signaling. Acts as a transcriptional corepressor of LBX1 (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046332 SMAD binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0030514 negative regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P84551-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84587-1", "uniprot_id": [ { "id": "ZN326_RAT", "url": "https://www.uniprot.org/uniprot/P84587", "type": "external" } ], "mass": 2439.0, "length": 22, "protein_name": "Zinc finger protein 326", "gene_name": "Znf326", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Znf326; Zfp326", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 326", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "16128803", "class_list": "", "function": "Probable transcriptional activator which may play a role in neuronal differentiation. Able to bind DNA and activate expression in vitro (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0016363 nuclear matrix", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P84587-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85107-1", "uniprot_id": [ { "id": "TGS1_RAT", "url": "https://www.uniprot.org/uniprot/P85107", "type": "external" } ], "mass": 96045.0, "length": 850, "protein_name": "Trimethylguanosine synthase", "gene_name": "Tgs1", "organism": "Rat", "refseq_name": "trimethylguanosine synthase", "refseq_ac": [ { "id": "NP_001101374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101374", "type": "external" } ], "gene_names_uniprotkb": "Tgs1; Ncoa6ip; Pimt", "gene_names_refseq": "Ncoa6ip; Tgs1", "protein_names_uniprotkb": "Trimethylguanosine synthase; 2.1.1.-; Cap-specific guanine-N(2) methyltransferase; Nuclear receptor coactivator 6-interacting protein; PIMT; PIPMT; PRIP-interacting protein with methyltransferase motif", "protein_names_refseq": "PIMT; PIPMT; PRIP-interacting protein with methyltransferase motif; cap-specific guanine-N(2) methyltransferase; nuclear receptor coactivator 6 interacting protein; trimethylguanosine synthase homolog; trimethylguanosine synthase", "tax_id": 10116, "disease": "", "pathway": " (rno:312947); (R-RNO-191859); (R-RNO-400206); (R-RNO-9707564)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "12943661;22673903;37175791", "class_list": "", "function": "Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PIMT Controls Insulin Synthesis and Secretion through PDX1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" } ], "go_molecular_function": "GO:0071164 RNA cap trimethylguanosine synthase activity;GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015030 Cajal body", "go_biological_process": "GO:0036261 7-methylguanosine cap hypermethylation;GO:0006351 DNA-templated transcription;GO:0071333 cellular response to glucose stimulus;GO:0042308 negative regulation of protein import into nucleus;GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P85107-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85844-1", "uniprot_id": [ { "id": "MUP2_RAT", "url": "https://www.uniprot.org/uniprot/P85844", "type": "external" } ], "mass": 1174.0, "length": 10, "protein_name": "Major urinary protein 2", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Major urinary protein 2; MUP 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P85844-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97532-1", "uniprot_id": [ { "id": "THTM_RAT", "url": "https://www.uniprot.org/uniprot/P97532", "type": "external" } ], "mass": 32940.0, "length": 297, "protein_name": "3-mercaptopyruvate sulfurtransferase", "gene_name": "Mpst", "organism": "Rat", "refseq_name": "3-mercaptopyruvate sulfurtransferase", "refseq_ac": [ { "id": "NP_620198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620198", "type": "external" } ], "gene_names_uniprotkb": "Mpst", "gene_names_refseq": "Mpst; Mst", "protein_names_uniprotkb": "3-mercaptopyruvate sulfurtransferase; 2.8.1.2; MST", "protein_names_refseq": "3-mercaptopyruvate sulfurtransferase", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:192172); (R-RNO-1614558)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "16107337;17130129;19605461;26519030;29331374;29393594;31893496;32813542;7608189;8910318;9749958", "class_list": "", "function": "3-Mercaptopyruvate sulfurtransferase/hydrogen sulfide protects cerebral endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury via mitoprotection and inhibition of the RhoA/ROCK pathway., [RefSeq, PubMed]; 3-Mercaptopyruvate sulphurtransferase and not cystathionine gamma-lyase is the primary regulator of coronary artery hydrogen sulfide production and function., [RefSeq, PubMed]; Presented is alternative pathway of production of hydrogen sulfide and/or polysulfides from (poly)sulfurated catalytic-site cysteine of reaction intermediates of MST via thioredoxin reduction., [RefSeq, PubMed]; The study revealed a significant role of MPST in hydrogen sulfide metabolism in the pancreas in experimental model of acute pancreatitis., [RefSeq, PubMed]; Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.2", "type": "external" } ], "go_molecular_function": "GO:0016784 3-mercaptopyruvate sulfurtransferase activity;GO:0042802 identical protein binding;GO:0004792 thiosulfate-cyanide sulfurtransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation;GO:0001889 liver development;GO:0021510 spinal cord development;GO:0001822 kidney development;GO:0019346 transsulfuration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P97532-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97580-1", "uniprot_id": [ { "id": "MSMB_RAT", "url": "https://www.uniprot.org/uniprot/P97580", "type": "external" } ], "mass": 12750.0, "length": 113, "protein_name": "Beta-microseminoprotein", "gene_name": "Msmb", "organism": "Rat", "refseq_name": "beta-microseminoprotein precursor", "refseq_ac": [ { "id": "NP_062061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062061", "type": "external" } ], "gene_names_uniprotkb": "Msmb; Psp94", "gene_names_refseq": "Msmb; PSP94", "protein_names_uniprotkb": "Beta-microseminoprotein; PSP-94; PSP94; Prostate secreted seminal plasma protein; Prostate secretory protein of 94 amino acids", "protein_names_refseq": "PSP-94; beta-microseminoprotein precursor; beta-microseminoprotein; prostate secreted seminal plasma protein; prostate secretory protein PSP94; prostate secretory protein of 94 amino acids", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); Huntington's disease (Disease Ontology:DOID:12858); Sjogren's syndrome (Disease Ontology:DOID:12894); dementia (Disease Ontology:DOID:1307); pancreatic cancer (Disease Ontology:DOID:1793); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); osteosarcoma (Disease Ontology:DOID:3347); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); lung small cell carcinoma (Disease Ontology:DOID:5409); viral encephalitis (Disease Ontology:DOID:646); chronic myeloid leukemia (Disease Ontology:DOID:8552); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:29311)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29250809;8837741", "class_list": "", "function": "Aggressive prostate tumors suppress MSMB synthesis in the benign prostate and this could explain why serum levels of MSMB are decreased in prostate cancer patients., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P97580-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97639-1", "uniprot_id": [ { "id": "MCHR1_RAT", "url": "https://www.uniprot.org/uniprot/P97639", "type": "external" } ], "mass": 39063.0, "length": 353, "protein_name": "Melanin-concentrating hormone receptor 1", "gene_name": "Mchr1", "organism": "Rat", "refseq_name": "melanin-concentrating hormone receptor 1", "refseq_ac": [ { "id": "NP_113946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113946", "type": "external" } ], "gene_names_uniprotkb": "Mchr1; Gpr24; Slc1", "gene_names_refseq": "Gpr24; Mch-1r; Mchr1; Slc1", "protein_names_uniprotkb": "Melanin-concentrating hormone receptor 1; G protein-coupled receptor 24; MCH receptor 1; MCH-1R; MCH-R1; MCH1R; MCHR-1; MCHR; SLC-1; Somatostatin receptor-like protein", "protein_names_refseq": "G-protein coupled receptor 24; MCH receptor 1; MCH-R1; MCH1R; MCHR-1; MCHR; SLC-1; melanin-concentrating hormone receptor 1; somatostatin receptor-like protein", "tax_id": 10116, "disease": "morbid obesity (Disease Ontology:DOID:11981); Parkinson's disease (Disease Ontology:DOID:14330); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:83567); (R-RNO-375276); (R-RNO-416476); (R-RNO-418594); (R-RNO-5620922)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10421367;10421368;10559938;12505154;27579857;32530066;33197527;36565982;8977118;9531978", "class_list": "", "function": "Acute intrahippocampal administration of melanin-concentrating hormone impairs memory consolidation and decreases the expression of MCHR-1 and TrkB receptors., [RefSeq, PubMed]; Ciliary melanin-concentrating hormone receptor 1 (MCHR1) is widely distributed in the murine CNS in a sex-independent manner., [RefSeq, PubMed]; Data suggest a dual role of MCH and the MCH1-R in regulation of alcohol intake, possibly through mechanisms involving caloric intake and reward motivation., [RefSeq, PubMed]; G protein-coupled receptor for melanin-concentrating hormone (MCH) that signals primarily through G(i/o) to inhibit adenylyl cyclase, and can additionally couple to G(q/11) to stimulate phospholipase C and mobilize intracellular calcium (PubMed:10421368, PubMed:10559938). Predominantly localized within the central nervous system where it regulates various physiological processes including feeding behavior, energy homeostasis, stress/anxiety-related behaviors and sleep (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Properties of primary cilia in melanin-concentrating hormone receptor 1-bearing hippocampal neurons in vivo and in vitro., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 3, "mined_n_glycosites": 3, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A140TAD3", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005102 signaling receptor binding;GO:0042562 hormone binding;GO:0042923 neuropeptide binding;GO:0030273 melanin-concentrating hormone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0043005 neuron projection;GO:0097730 non-motile cilium;GO:0060170 ciliary membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0051928 positive regulation of calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P97639-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000100000000.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97826-1", "uniprot_id": [ { "id": "STAR_RAT", "url": "https://www.uniprot.org/uniprot/P97826", "type": "external" } ], "mass": 31501.0, "length": 284, "protein_name": "Steroidogenic acute regulatory protein, mitochondrial", "gene_name": "Star", "organism": "Rat", "refseq_name": "steroidogenic acute regulatory protein, mitochondrial precursor", "refseq_ac": [ { "id": "NP_113746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113746", "type": "external" } ], "gene_names_uniprotkb": "Star", "gene_names_refseq": "Star", "protein_names_uniprotkb": "Steroidogenic acute regulatory protein, mitochondrial; START domain-containing protein 1; StARD1; StAR", "protein_names_refseq": "START domain-containing protein 1; stARD1; steroidogenic acute regulatory protein, mitochondrial precursor; steroidogenic acute regulatory protein, mitochondrial", "tax_id": 10116, "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); chromosome 1q21.1 deletion syndrome (Disease Ontology:DOID:0060411); polycystic ovary syndrome (Disease Ontology:DOID:11612); hypothyroidism (Disease Ontology:DOID:1459); hypogonadism (Disease Ontology:DOID:1924); nephrosis (Disease Ontology:DOID:2527); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25557); (R-RNO-196108); (R-RNO-9837999)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "12768544;33670702;35871495;38517482;39094930;7626524;9015355;9328229;9516465;9832120", "class_list": "", "function": "DNA methylation of Ad4BP/SF-1 suppresses Cyp11a1 and StAR transcripts in C2C12 myoblasts., [RefSeq, PubMed]; Identification of a mechanism promoting mitochondrial sterol accumulation during myocardial ischemia-reperfusion: role of TSPO and STAR., [RefSeq, PubMed]; Interplay between polycystic ovary syndrome and hypothyroidism on serum testosterone, oxidative stress and StAR gene expression in female rats., [RefSeq, PubMed]; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity)., [UniProtKB, UniProtKB]; Role of Constitutive STAR in Leydig Cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97628", "ec_number_list": [], "go_molecular_function": "GO:0015485 cholesterol binding;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005759 mitochondrial matrix;GO:0043025 neuronal cell body;GO:0030061 mitochondrial crista", "go_biological_process": "GO:0070859 positive regulation of bile acid biosynthetic process;GO:0035457 cellular response to interferon-alpha;GO:0071378 cellular response to growth hormone stimulus;GO:0006629 lipid metabolic process;GO:0006699 bile acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P97826-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97849-1", "uniprot_id": [ { "id": "S27A1_RAT", "url": "https://www.uniprot.org/uniprot/P97849", "type": "external" } ], "mass": 71283.0, "length": 646, "protein_name": "Long-chain fatty acid transport protein 1", "gene_name": "Slc27a1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc27a1; Fatp1; Fatp", "gene_names_refseq": "", "protein_names_uniprotkb": "Long-chain fatty acid transport protein 1; 6.2.1.-; 6.2.1.15; 6.2.1.3; Arachidonate--CoA ligase; FATP-1; Fatty acid transport protein 1; Fatty acid transport protein; Long-chain-fatty-acid--CoA ligase; Solute carrier family 27 member 1; Very long-chain acyl-CoA synthetase", "protein_names_refseq": "", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); glucose intolerance (Disease Ontology:DOID:10603); familial hyperlipidemia (Disease Ontology:DOID:1168); hyperinsulinism (Disease Ontology:DOID:2018); myocardial infarction (Disease Ontology:DOID:5844); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:94172); (R-RNO-804914)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15848183;19380575;29393594;38843836;9375787", "class_list": "", "function": "Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (PubMed:19380575). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Probably involved in fatty acid transport across the blood barrier (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.76", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0015245 fatty acid transmembrane transporter activity;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0004467 long-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005901 caveola", "go_biological_process": "GO:1990379 lipid transport across blood-brain barrier;GO:0015878 biotin transport;GO:0001676 long-chain fatty acid metabolic process;GO:0009409 response to cold;GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P97849-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00788-1", "uniprot_id": [ { "id": "V2R_RAT", "url": "https://www.uniprot.org/uniprot/Q00788", "type": "external" } ], "mass": 40749.0, "length": 371, "protein_name": "Vasopressin V2 receptor", "gene_name": "Avpr2", "organism": "Rat", "refseq_name": "vasopressin V2 receptor", "refseq_ac": [ { "id": "NP_062009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062009", "type": "external" } ], "gene_names_uniprotkb": "Avpr2", "gene_names_refseq": "Avpr2", "protein_names_uniprotkb": "Vasopressin V2 receptor; AVPR V2; Antidiuretic hormone receptor; Renal-type arginine vasopressin receptor; V2R", "protein_names_refseq": "AVPR V2; V2R; Vasopressin receptor V2; antidiuretic hormone receptor; renal-type arginine vasopressin receptor; vasopressin V2 receptor", "tax_id": 10116, "disease": "autosomal dominant nonsyndromic deafness 37 (Disease Ontology:DOID:0070601); Stickler syndrome (Disease Ontology:DOID:0080046); fibrochondrogenesis 1 (Disease Ontology:DOID:0080672); Stickler syndrome 2 (Disease Ontology:DOID:0080675); X-linked nephrogenic diabetes insipidus (Disease Ontology:DOID:0081060); Marshall syndrome (Disease Ontology:DOID:0111510); nephrogenic syndrome of inappropriate antidiuresis (Disease Ontology:DOID:0112121); hypertension (Disease Ontology:DOID:10763); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); ureteral obstruction (Disease Ontology:DOID:5199); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (rno:25108); (R-RNO-388479); (R-RNO-432040); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "1534150;26924211;30944256;31691500;32165443;33000260;7708485", "class_list": "", "function": "Chronic vasopressin V2R antagonism may contribute to the worsening of PAH and the development of RV remodeling., [RefSeq, PubMed]; G protein-coupled receptor for arginine vasopressin, an antidiuretic that promotes renal water reabsorption (PubMed:1534150). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (By similarity). AVPR2 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (By similarity)., [UniProtKB, PubMed, UniProtKB]; Hypoxia in utero increases the risk of pulmonary hypertension in rat offspring and is associated with vasopressin type2 receptor upregulation., [RefSeq, PubMed]; Inner Ear Arginine Vasopressin-Vasopressin Receptor 2-Aquaporin 2 Signaling Pathway Is Involved in the Induction of Motion Sickness., [RefSeq, PubMed]; Periconceptional ethanol exposure induces a sex specific diuresis and increase in AQP2 and AVPR2 in the kidneys of aged rat offspring., [RefSeq, PubMed]; Site-1 protease-derived (S1P-derived) soluble (pro)renin receptor (sPRR) participates in regulation of fluid homeostasis via targeting V2R. In cultured rat inner medullary collecting duct (IMCD) cells, AVP-induced V2R expression was blunted by a PRR antagonist, PRO20; a PRR-neutralizing antibody; or a S1P inhibitor, PF-429242. In parallel, sPRR release was increased by AVP and reduced by PF-429242. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q53ZC4", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0038023 signaling receptor activity;GO:0005000 vasopressin receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q00788-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03346-1", "uniprot_id": [ { "id": "MPPB_RAT", "url": "https://www.uniprot.org/uniprot/Q03346", "type": "external" } ], "mass": 54265.0, "length": 489, "protein_name": "Mitochondrial-processing peptidase subunit beta", "gene_name": "Pmpcb", "organism": "Rat", "refseq_name": "mitochondrial-processing peptidase subunit beta precursor", "refseq_ac": [ { "id": "NP_071790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071790", "type": "external" } ], "gene_names_uniprotkb": "Pmpcb; Mppb", "gene_names_refseq": "Mppb; Pmpcb", "protein_names_uniprotkb": "Mitochondrial-processing peptidase subunit beta; 3.4.24.64; Beta-MPP; P-52", "protein_names_refseq": "P-52; beta-MPP; mitochondrial processing peptidase beta subunit; mitochondrial-processing peptidase subunit beta precursor; mitochondrial-processing peptidase subunit beta; peptidase (mitochondrial processing) beta; peptidase, mitochondrial processing beta subunit", "tax_id": 10116, "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); multiple mitochondrial dysfunctions syndrome 6 (Disease Ontology:DOID:0070332)", "pathway": " (rno:64198); (R-RNO-8949664)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12433926;22354088;8422255;8506385", "class_list": "", "function": "Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable) (PubMed:12433926). Preferentially, cleaves after an arginine at position P2 (PubMed:12433926). Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis (PubMed:22354088)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q68G08", "ec_number_list": [ { "id": "3.4.24.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.64", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0009003 signal peptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0017087 mitochondrial processing peptidase complex;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016485 protein processing;GO:0006627 protein processing involved in protein targeting to mitochondrion;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q03346-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05310-1", "uniprot_id": [ { "id": "L10K_RAT", "url": "https://www.uniprot.org/uniprot/Q05310", "type": "external" } ], "mass": 9984.0, "length": 93, "protein_name": "Leydig cell tumor 10 kDa protein", "gene_name": "", "organism": "Rat", "refseq_name": "leydig cell tumor 10 kDa protein", "refseq_ac": [ { "id": "NP_942023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942023", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "C19h19orf53", "protein_names_uniprotkb": "Leydig cell tumor 10 kDa protein", "protein_names_refseq": "leydig cell tumor 10 kDa protein", "tax_id": 10116, "disease": "", "pathway": " (rno:288913)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1482688", "class_list": "", "function": "May have a potential role in hypercalcemia of malignancy., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q05310-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07205-1", "uniprot_id": [ { "id": "IF5_RAT", "url": "https://www.uniprot.org/uniprot/Q07205", "type": "external" } ], "mass": 48954.0, "length": 429, "protein_name": "Eukaryotic translation initiation factor 5", "gene_name": "Eif5", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 5", "refseq_ac": [ { "id": "NP_001316808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001316808", "type": "external" } ], "gene_names_uniprotkb": "Eif5", "gene_names_refseq": "Eif5; eIF-5", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 5; eIF-5", "protein_names_refseq": "eukaryotic initiation factor 5 (eIF-5); eukaryotic initiation factor 5; eukaryotic translation initiation factor 5", "tax_id": 10116, "disease": "", "pathway": " (rno:108348073); (R-RNO-72702)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11861906;22673903;8464924", "class_list": "", "function": "Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC. When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP. Start codon recognition also induces a conformational change of the PIC to a closed state. This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC. Finally, EIF5 stabilizes the PIC in its closed conformation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071074 eukaryotic initiation factor eIF2 binding;GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0003743 translation initiation factor activity;GO:0005092 GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0090630 activation of GTPase activity;GO:0006446 regulation of translational initiation;GO:0001731 formation of translation preinitiation complex;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0042255 ribosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q07205-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07977-1", "uniprot_id": [ { "id": "SIA8B_RAT", "url": "https://www.uniprot.org/uniprot/Q07977", "type": "external" } ], "mass": 42400.0, "length": 375, "protein_name": "Alpha-2,8-sialyltransferase 8B", "gene_name": "St8sia2", "organism": "Rat", "refseq_name": "alpha-2,8-sialyltransferase 8B precursor", "refseq_ac": [ { "id": "NP_476497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476497", "type": "external" } ], "gene_names_uniprotkb": "St8sia2; Siat8b; Stx", "gene_names_refseq": "SIAT8-B; STX; Siat8b; St8sia2", "protein_names_uniprotkb": "Alpha-2,8-sialyltransferase 8B; 2.4.3.-; SIAT8-B; ST8SiaII; STX; Sialyltransferase 8B; Sialyltransferase St8Sia II; Sialyltransferase X", "protein_names_refseq": "ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 2; ST8Sia II; ST8SiaII; alpha-2,8-sialyltransferase 8B precursor; alpha-2,8-sialyltransferase 8B; sialyltransferase 8 (alpha-2, 8-sialyltransferase) B; sialyltransferase 8 (alpha-2, 8-sialytransferase) B; sialyltransferase St8Sia II; sialyltransferase X; sialytransferase St8Sia II", "tax_id": 10116, "disease": "", "pathway": " (rno:117523); (R-RNO-4085001); (R-RNO-419037); (R-RNO-975577)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "16887122;24753009;26844880;7685014", "class_list": "glycogene;glycosyltransferase", "function": "After learning an olfactory discrimination task, no changes in STX gene expression level were observed in the olfactory bulb., [RefSeq, PubMed]; Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan acceptor through alpha-2,8-linkages. Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides (alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid), including NCAM1, NCAM1 N-glycans, FETUB N-glycans, and to a lesser extent sialylparagloboside (SPG) and AHSG, which does not require the initial addition of an alpha 2,8-sialic acid (By similarity). However, does not exhibit sialic acid-polymerase activity (By similarity). Catalyzes polysialic acid synthesis in the hippocampal on NCAM1 and supports neurite outgrowth (By similarity). ST8SIA2-mediated polysialylation influences on oligodendrocyte differentiation and may promote the integrity of myelin and axons (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results suggest that sialyltransferase-X is probably involved in the proliferation of neural progenitor cells; polysialyltransferase may play a key role in synaptic plasticity of mature neural networks, [RefSeq, PubMed]; ST8SiaII/STX expression is essential to allow a correct neuritic development at initial stages of hippocampus ontogeny, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q64688", "ec_number_list": [ { "id": "2.4.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.8", "type": "external" }, { "id": "2.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.-", "type": "external" }, { "id": "2.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.-", "type": "external" } ], "go_molecular_function": "GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;GO:0000166 nucleotide binding;GO:0008373 sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0030182 neuron differentiation;GO:0042220 response to cocaine;GO:0051965 positive regulation of synapse assembly;GO:0043525 positive regulation of neuron apoptotic process", "synthesized_glycan_count": 21, "hit_score": 0.5, "record_id": "Q07977-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08415-2", "uniprot_id": [ { "id": "KAT1_RAT", "url": "https://www.uniprot.org/uniprot/Q08415", "type": "external" } ], "mass": 47873.0, "length": 423, "protein_name": "Kynurenine--oxoglutarate transaminase 1", "gene_name": "Kyat1", "organism": "Rat", "refseq_name": "kynurenine--oxoglutarate transaminase 1 isoform a", "refseq_ac": [ { "id": "NP_001013182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013182", "type": "external" } ], "gene_names_uniprotkb": "Kyat1; Ccbl1; Kat", "gene_names_refseq": "Ccbl1; Gtk; Kat1; KatI; Kyat1", "protein_names_uniprotkb": "Kynurenine--oxoglutarate transaminase 1; 2.6.1.64; 2.6.1.7; 4.4.1.13; Cysteine-S-conjugate beta-lyase; GTK; Glutamine transaminase K; Glutamine--phenylpyruvate transaminase; KATI; Kynurenine aminotransferase 1; Kynurenine aminotransferase I; Kynurenine--oxoglutarate transaminase I", "protein_names_refseq": "cysteine conjugate-beta lyase 1; cysteine conjugate-beta lyase, cytoplasmic; cysteine-S-conjugate beta-lyase; glutamine transaminase K; glutamine--phenylpyruvate transaminase; kynurenine aminotransferase I; kynurenine aminotransferase/glutamine transaminase K; kynurenine--oxoglutarate transaminase 1 isoform a; kynurenine--oxoglutarate transaminase 1, mitochondrial; kynurenine--oxoglutarate transaminase I", "tax_id": 10116, "disease": "", "pathway": " (rno:311844); (R-RNO-71240); (R-RNO-8964208); (R-RNO-8964539)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "12850267;2072101;6783036;7796908;7926014;8502223", "class_list": "", "function": "Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others (PubMed:2072101, PubMed:6783036, PubMed:7796908). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:8502223)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R096", "ec_number_list": [ { "id": "2.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.7", "type": "external" }, { "id": "2.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.1", "type": "external" }, { "id": "2.6.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.64", "type": "external" }, { "id": "4.4.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.13", "type": "external" }, { "id": "2.6.1.63", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.63", "type": "external" }, { "id": "2.6.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.39", "type": "external" }, { "id": "2.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.4", "type": "external" }, { "id": "2.6.1.73", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.73", "type": "external" } ], "go_molecular_function": "GO:0047316 glutamine-phenylpyruvate transaminase activity;GO:0016212 kynurenine-oxoglutarate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0042803 protein homodimerization activity;GO:0047804 cysteine-S-conjugate beta-lyase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0097053 L-kynurenine catabolic process;GO:0070189 kynurenine metabolic process;GO:0009617 response to bacterium;GO:0042867 pyruvate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q08415-2", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08469-1", "uniprot_id": [ { "id": "S6A15_RAT", "url": "https://www.uniprot.org/uniprot/Q08469", "type": "external" } ], "mass": 81596.0, "length": 729, "protein_name": "Sodium-dependent neutral amino acid transporter B(0)AT2", "gene_name": "Slc6a15", "organism": "Rat", "refseq_name": "sodium-dependent neutral amino acid transporter B(0)AT2", "refseq_ac": [ { "id": "NP_758824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758824", "type": "external" } ], "gene_names_uniprotkb": "Slc6a15; Ntt73", "gene_names_refseq": "Ntt73; Slc6a15", "protein_names_uniprotkb": "Sodium-dependent neutral amino acid transporter B(0)AT2; Solute carrier family 6 member 15; Transporter v7-3; sodium- and chloride-dependent neurotransmitter transporter NTT73", "protein_names_refseq": "orphan sodium- and chloride-dependent neurotransmitter transporter NTT73; orphan transporter v7-3; sodium-dependent neutral amino acid transporter B(0)AT2; solute carrier family 6 (neurotransmitter transporter), member 15; solute carrier family 6 (neutral amino acid transporter), member 15; transporter v7-3", "tax_id": 10116, "disease": "", "pathway": " (rno:282712); (R-RNO-352230); (R-RNO-442660)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "1363329;19147495;22673903;8738154", "class_list": "", "function": "Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent., [UniProtKB, UniProtKB]; The substrate profile of the NTT4/XT1-dependent activity is similar to that of the closely related B(0)AT2/SBAT1 (SLC6A15), including a submillimolar apparent affinity for proline and leucine and a low millimolar apparent affinity for glutamine., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q63838", "ec_number_list": [], "go_molecular_function": "GO:0005298 proline:sodium symporter activity;GO:0005295 neutral L-amino acid:sodium symporter activity;GO:0015657 branched-chain amino acid:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0015820 L-leucine transport;GO:0015824 proline transport;GO:0015804 neutral amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0006836 neurotransmitter transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q08469-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09167-1", "uniprot_id": [ { "id": "SRSF5_RAT", "url": "https://www.uniprot.org/uniprot/Q09167", "type": "external" } ], "mass": 30891.0, "length": 269, "protein_name": "Serine/arginine-rich splicing factor 5", "gene_name": "Srsf5", "organism": "Rat", "refseq_name": "serine/arginine-rich splicing factor 5", "refseq_ac": [ { "id": "NP_001182434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182434", "type": "external" } ], "gene_names_uniprotkb": "Srsf5; Cl-4; Hrs; Sfrs5", "gene_names_refseq": "HRS; SRp40; Sfrs5; Srsf5", "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 5; Delayed-early protein HRS; Insulin-induced growth response protein CL-4; Pre-mRNA-splicing factor SRP40; Splicing factor, arginine/serine-rich 5", "protein_names_refseq": "delayed-early protein HRS; insulin-induced growth response protein CL-4; pre-mRNA-splicing factor SRP40; serine/arginine-rich splicing factor 5; splicing factor, arginine/serine-rich 5 (SRp40, HRS)", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease type 4H (Disease Ontology:DOID:0110192); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); breast cancer (Disease Ontology:DOID:1612); colon adenocarcinoma (Disease Ontology:DOID:234); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); X-linked Aarskog syndrome (Disease Ontology:DOID:6683)", "pathway": " (rno:29667); (R-RNO-159236); (R-RNO-72163); (R-RNO-72203); (R-RNO-9770562)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "22673903;7686911;8161377;9434190", "class_list": "", "function": "May be required for progression through G1 and entry into S phase of cell growth. May play a regulatory role in pre-mRNA splicing. Autoregulates its own expression. Plays a role in constitutive splicing and can modulate the selection of alternative splice sites (By similarity). Could play an important role in development and differentiation in the spleen and thymus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35335", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0043422 protein kinase B binding;GO:0050733 RS domain binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q09167-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0D2L3-1", "uniprot_id": [ { "id": "GDAH_RAT", "url": "https://www.uniprot.org/uniprot/Q0D2L3", "type": "external" } ], "mass": 37987.0, "length": 353, "protein_name": "Guanidino acid hydrolase, mitochondrial", "gene_name": "Agmat", "organism": "Rat", "refseq_name": "guanidino acid hydrolase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001041650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041650", "type": "external" } ], "gene_names_uniprotkb": "Agmat; Gdah", "gene_names_refseq": "Agmat", "protein_names_uniprotkb": "Guanidino acid hydrolase, mitochondrial; 3.5.3.-; 3.5.3.17; 3.5.3.1; 3.5.3.7; Arginase, mitochondrial; Guanidinobutyrase, mitochondrial; Guanidinopropionase, mitochondrial", "protein_names_refseq": "AUH; agmatinase, mitochondrial; agmatine ureohydrolase (agmatinase); arginase, mitochondrial; guanidino acid hydrolase, mitochondrial precursor; guanidino acid hydrolase, mitochondrial; guanidinobutyrase, mitochondrial; guanidinopropionase, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:298607); (R-RNO-351143)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17291445;20563878;22160263;36849038", "class_list": "", "function": "Agmatinase activity is adscribed to a novel protein with an active site that promiscuously catalyzes a reaction other than the one it evolved to catalyze., [RefSeq, PubMed]; Agmatinase activity was predominantly detected in neurons of rat and human brain., [RefSeq, PubMed]; Hydrolyzes linear guanidino acids to form urea and the corresponding amines. Displays specificity for substrates having a negatively charged head group and short chains including taurocyamine, guanidino propanoic and butanoic acids. May protect cells by detoxifying potentially harmful amounts of guanidino acids. Metabolizes L-arginine with low efficiency., [UniProtKB, UniProtKB]; Pre- and postsynaptic expression of agmatinase in rats supports a proposed role in the modulation of the neurotransmitter agmatin., [RefSeq, PubMed]; The expression of agmatinase manipulates the affective state of rats subjected to chronic restraint stress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BK25", "ec_number_list": [ { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.5.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.-", "type": "external" }, { "id": "3.5.3.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.17", "type": "external" }, { "id": "3.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.7", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004053 arginase activity;GO:0008783 agmatinase activity;GO:0047971 guanidinobutyrase activity;GO:0047972 guanidinopropionase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0000050 urea cycle;GO:0033389 putrescine biosynthetic process from arginine, via agmatine", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q0D2L3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0PGW2-1", "uniprot_id": [ { "id": "DEN11_RAT", "url": "https://www.uniprot.org/uniprot/Q0PGW2", "type": "external" } ], "mass": 51370.0, "length": 455, "protein_name": "DENN domain-containing protein 11", "gene_name": "Dennd11", "organism": "Rat", "refseq_name": "DENN domain-containing protein 11", "refseq_ac": [ { "id": "NP_001038166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038166", "type": "external" } ], "gene_names_uniprotkb": "Dennd11; Lchn", "gene_names_refseq": "Dennd11; LCHN; RGD1563986", "protein_names_uniprotkb": "DENN domain-containing protein 11; DENND11; Protein LCHN", "protein_names_refseq": "DENN domain-containing protein 11; protein LCHN", "tax_id": 10116, "disease": "", "pathway": " (rno:312270)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17394467", "class_list": "", "function": "Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia., [UniProtKB, PubMed]; Taken together, these data suggest that LCHN could play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0PGW2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2LAP6-1", "uniprot_id": [ { "id": "TES_RAT", "url": "https://www.uniprot.org/uniprot/Q2LAP6", "type": "external" } ], "mass": 47632.0, "length": 419, "protein_name": "Testin", "gene_name": "Tes", "organism": "Rat", "refseq_name": "testin", "refseq_ac": [ { "id": "NP_001034433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034433", "type": "external" } ], "gene_names_uniprotkb": "Tes", "gene_names_refseq": "Tes", "protein_names_uniprotkb": "Testin", "protein_names_refseq": "testin; testis derived transcript", "tax_id": 10116, "disease": "childhood acute lymphocytic leukemia (Disease Ontology:DOID:0080144); stomach cancer (Disease Ontology:DOID:10534); breast cancer (Disease Ontology:DOID:1612); endometrial carcinoma (Disease Ontology:DOID:2871); high grade glioma (Disease Ontology:DOID:3070); lung non-small cell carcinoma (Disease Ontology:DOID:3908); uterine corpus sarcoma (Disease Ontology:DOID:5165); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:500040)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12917688;21278383", "class_list": "", "function": "Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0032991 protein-containing complex", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2LAP6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TGI5-1", "uniprot_id": [ { "id": "ZDH24_RAT", "url": "https://www.uniprot.org/uniprot/Q2TGI5", "type": "external" } ], "mass": 30696.0, "length": 284, "protein_name": "Probable palmitoyltransferase ZDHHC24", "gene_name": "Zdhhc24", "organism": "Rat", "refseq_name": "probable palmitoyltransferase ZDHHC24", "refseq_ac": [ { "id": "NP_001034189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034189", "type": "external" } ], "gene_names_uniprotkb": "Zdhhc24", "gene_names_refseq": "Zdhhc24", "protein_names_uniprotkb": "Probable palmitoyltransferase ZDHHC24; 2.3.1.225; DHHC-24; Membrane-associated zinc finger protein DHHC25; Zinc finger DHHC domain-containing protein 24", "protein_names_refseq": "DHHC-24; membrane-associated DHHC25 zinc finger protein; membrane-associated zinc finger protein DHHC25; probable palmitoyltransferase ZDHHC24; zinc finger DHHC domain-containing protein 24; zinc finger, DHHC domain containing 24; zinc finger, DHHC-type containing 24", "tax_id": 10116, "disease": "", "pathway": " (rno:293665)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0006612 protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TGI5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TGI8-1", "uniprot_id": [ { "id": "ZDH22_RAT", "url": "https://www.uniprot.org/uniprot/Q2TGI8", "type": "external" } ], "mass": 29249.0, "length": 263, "protein_name": "Palmitoyltransferase ZDHHC22", "gene_name": "Zdhhc22", "organism": "Rat", "refseq_name": "palmitoyltransferase ZDHHC22", "refseq_ac": [ { "id": "NP_001034414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034414", "type": "external" } ], "gene_names_uniprotkb": "Zdhhc22", "gene_names_refseq": "Zdhhc22", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC22; 2.3.1.225; DHHC-22; Zinc finger DHHC domain-containing protein 22; zDHHC22", "protein_names_refseq": "DHHC-22; membrane-associated DHHC22 zinc finger protein; palmitoyltransferase ZDHHC22; putative palmitoyltransferase ZDHHC22; zinc finger DHHC domain-containing protein 22; zinc finger DHHC-type palmitoyltransferase 22; zinc finger, DHHC domain containing 22; zinc finger, DHHC-type containing 22", "tax_id": 10116, "disease": "", "pathway": " (rno:299211)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (By similarity). Catalyzes the palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane (By similarity). Might also mediate palmitoylation of CNN3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006612 protein targeting to membrane;GO:0018345 protein palmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TGI8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TGJ4-1", "uniprot_id": [ { "id": "ZDH15_RAT", "url": "https://www.uniprot.org/uniprot/Q2TGJ4", "type": "external" } ], "mass": 39308.0, "length": 337, "protein_name": "Palmitoyltransferase ZDHHC15", "gene_name": "Zdhhc15", "organism": "Rat", "refseq_name": "palmitoyltransferase ZDHHC15", "refseq_ac": [ { "id": "NP_001034190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034190", "type": "external" } ], "gene_names_uniprotkb": "Zdhhc15", "gene_names_refseq": "Zdhhc15", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC15; 2.3.1.-; 2.3.1.225; Acyltransferase ZDHHC15; DHHC-15; Zinc finger DHHC domain-containing protein 15", "protein_names_refseq": "DHHC-15; acyltransferase ZDHHC15; membrane-associated DHHC15 zinc finger protein; palmitoyltransferase ZDHHC15; zinc finger DHHC domain-containing protein 15; zinc finger DHHC-type palmitoyltransferase 15; zinc finger, DHHC domain containing 15; zinc finger, DHHC-type containing 15", "tax_id": 10116, "disease": "syndrome (Disease Ontology:DOID:225)", "pathway": " (rno:317235)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31189538", "class_list": "", "function": "Knocking down zDHHC15 in primary rat hippocampal cultures reduces dendritic outgrowth and arborization, as well as spine maturation. Publication Status: Online-Only, [RefSeq, PubMed]; Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (By similarity). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoylates IGF2R and SORT1, promoting their partitioning to an endosomal membrane subdomain where they can interact with the retromer cargo-selective complex (By similarity). Thereby, regulates retrograde transport from endosomes to the Golgi apparatus of these lysosomal sorting receptors and plays a role in trafficking of lysosomal proteins (By similarity). In the nervous system, catalyzes the palmitoylation of DLG4/PSD95 and regulates its synaptic clustering and function in synaptogenesis (PubMed:31189538). Could be involved in the differentiation of dopaminergic neurons and the development of the diencephalon (By similarity). Could also catalyze the palmitoylation of GAP43 (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Could also palmitoylate FYN as shown in vitro (By similarity). May palmitoylate CALHM3 subunit of gustatory voltage-gated ion channels and modulate channel gating and kinetics., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity;GO:0019705 protein-cysteine S-myristoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0014069 postsynaptic density;GO:0098794 postsynapse", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0045184 establishment of protein localization;GO:0072657 protein localization to membrane;GO:0061001 regulation of dendritic spine morphogenesis;GO:1900006 positive regulation of dendrite development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2TGJ4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2THW7-1", "uniprot_id": [ { "id": "ZDHC5_RAT", "url": "https://www.uniprot.org/uniprot/Q2THW7", "type": "external" } ], "mass": 77430.0, "length": 715, "protein_name": "Palmitoyltransferase ZDHHC5", "gene_name": "Zdhhc5", "organism": "Rat", "refseq_name": "palmitoyltransferase ZDHHC5", "refseq_ac": [ { "id": "NP_001034427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034427", "type": "external" } ], "gene_names_uniprotkb": "Zdhhc5", "gene_names_refseq": "DHHC-5; Zdhhc5", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC5; 2.3.1.225; DHHC-5; Zinc finger DHHC domain-containing protein 5", "protein_names_refseq": "membrane-associated DHHC5 zinc finger protein; palmitoyltransferase ZDHHC5; probable palmitoyltransferase ZDHHC5; zinc finger DHHC domain-containing protein 5; zinc finger DHHC-type palmitoyltransferase 5; zinc finger, DHHC domain containing 5; zinc finger, DHHC-type containing 5", "tax_id": 10116, "disease": "", "pathway": " (rno:362156)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21820437;22325201;22673903;26334723;31547976;32958558", "class_list": "", "function": "DHHC5, to palmitoylate substrates in an activity-dependent manner is dependent on changes in its subcellular localization. Publication Status: Online-Only, [RefSeq, PubMed]; Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:31547976). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (By similarity). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (By similarity). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (By similarity). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (By similarity). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (By similarity). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (By similarity). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (By similarity). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (By similarity). Palmitoylates NLRP3 to promote inflammasome assembly and activation (By similarity). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (By similarity). Palmitoylates IFT81 and may contribute to maintaining its protein stability during spermatogenesis thereby supporting proper sperm tail assembly (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; The palmitoyl acyltransferases ZDHHC5 and ZDHHC8 are uniquely present in DRG axons and control retrograde signaling via the Gp130/JAK/STAT3 pathway., [RefSeq, PubMed]; This study identified the first neuronal DHHC5/8 substrate, define novel mechanisms controlling palmitoylation specificity, and suggest further links between dysregulated palmitoylation and neuropathological conditions., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0006869 lipid transport;GO:0007283 spermatogenesis;GO:0045087 innate immune response;GO:0072659 protein localization to plasma membrane;GO:1903078 positive regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q2THW7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B8Q3-1", "uniprot_id": [ { "id": "S38A9_RAT", "url": "https://www.uniprot.org/uniprot/Q3B8Q3", "type": "external" } ], "mass": 63418.0, "length": 559, "protein_name": "Neutral amino acid transporter 9", "gene_name": "Slc38a9", "organism": "Rat", "refseq_name": "neutral amino acid transporter 9", "refseq_ac": [ { "id": "NP_001030328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030328", "type": "external" } ], "gene_names_uniprotkb": "Slc38a9", "gene_names_refseq": "RGD1311881; Slc38a9", "protein_names_uniprotkb": "Neutral amino acid transporter 9; Solute carrier family 38 member 9", "protein_names_refseq": "neutral amino acid transporter 9; putative sodium-coupled neutral amino acid transporter 9", "tax_id": 10116, "disease": "", "pathway": " (rno:310091); (R-RNO-1632852); (R-RNO-165159); (R-RNO-166208); (R-RNO-380972); (R-RNO-5628897); (R-RNO-8943724); (R-RNO-9639288)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids. Acts as an arginine sensor. Following activation by arginine binding, mediates transport of L-glutamine, leucine and tyrosine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation. However, the transport mechanism is not well defined and the role of sodium is not clear. Can disassemble the lysosomal folliculin complex (LFC), and thereby triggers GAP activity of FLCN:FNIP2 toward RRAGC. Acts as an cholesterol sensor that conveys increases in lysosomal cholesterol, leading to lysosomal recruitment and activation of mTORC1 via the Rag GTPases. Guanine exchange factor (GEF) that, upon arginine binding, stimulates GDP release from RRAGA and therefore activates the Rag GTPase heterodimer and the mTORC1 pathway in response to nutrient sufficiency., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q561Z8;R9PXU2", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0008324 monoatomic cation transmembrane transporter activity;GO:0046872 metal ion binding;GO:0015485 cholesterol binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0005770 late endosome;GO:0071986 Ragulator complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006868 glutamine transport;GO:0032008 positive regulation of TOR signaling;GO:0071230 cellular response to amino acid stimulus;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3B8Q3-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KR99-1", "uniprot_id": [ { "id": "SPDLY_RAT", "url": "https://www.uniprot.org/uniprot/Q3KR99", "type": "external" } ], "mass": 69112.0, "length": 597, "protein_name": "Protein Spindly", "gene_name": "Spdl1", "organism": "Rat", "refseq_name": "protein Spindly", "refseq_ac": [ { "id": "NP_001029310", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029310", "type": "external" } ], "gene_names_uniprotkb": "Spdl1; CCDC99; Ccdc99; SPDL1", "gene_names_refseq": "Ccdc99; RGD1306908; Spdl1", "protein_names_uniprotkb": "Protein Spindly; Coiled-coil domain-containing protein 99; Spindle apparatus coiled-coil domain-containing protein 1", "protein_names_refseq": "coiled-coil domain containing 99; coiled-coil domain-containing protein 99; protein Spindly; spindle apparatus coiled-coil domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:303037); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the localization of dynein and dynactin to the mitotic kinetochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Plays a role in cell migration (By similarity)., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0043515 kinetochore binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0000940 outer kinetochore", "go_biological_process": "GO:0016477 cell migration;GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0007080 mitotic metaphase chromosome alignment;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3KR99-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KRF1-1", "uniprot_id": [ { "id": "SP110_RAT", "url": "https://www.uniprot.org/uniprot/Q3KRF1", "type": "external" } ], "mass": 53205.0, "length": 478, "protein_name": "Sp110 nuclear body protein", "gene_name": "Sp110", "organism": "Rat", "refseq_name": "sp110 nuclear body protein isoform 1", "refseq_ac": [ { "id": "NP_001029309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029309", "type": "external" } ], "gene_names_uniprotkb": "Sp110; Ipr1", "gene_names_refseq": "Sp110", "protein_names_uniprotkb": "Sp110 nuclear body protein; Intracellular pathogen resistance protein 1", "protein_names_refseq": "intracellular pathogen resistance protein 1; sp110 nuclear body protein isoform 1", "tax_id": 10116, "disease": "hepatic venoocclusive disease with immunodeficiency (Disease Ontology:DOID:0112254); tuberculosis (Disease Ontology:DOID:399)", "pathway": " (rno:301570)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "May act as a transcription factor. Plays a role in the innate immunity against intracellular pathogens. Required for resistance to M.tuberculosis and L.monocytogenes. Promotes apoptosis of infected cells (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043065 positive regulation of apoptotic process;GO:0045087 innate immune response;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3KRF1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHS2-1", "uniprot_id": [ { "id": "ZN830_RAT", "url": "https://www.uniprot.org/uniprot/Q3MHS2", "type": "external" } ], "mass": 41616.0, "length": 370, "protein_name": "Zinc finger protein 830", "gene_name": "Znf830", "organism": "Rat", "refseq_name": "zinc finger protein 830", "refseq_ac": [ { "id": "NP_001032437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032437", "type": "external" } ], "gene_names_uniprotkb": "Znf830; Ccdc16; Zfp830", "gene_names_refseq": "Ccdc16; Zfp830; Znf830", "protein_names_uniprotkb": "Zinc finger protein 830; Coiled-coil domain-containing protein 16", "protein_names_refseq": "coiled-coil domain containing 16; coiled-coil domain-containing protein 16; zinc finger protein 830", "tax_id": 10116, "disease": "", "pathway": " (rno:497967); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-72163)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May play a role in pre-mRNA splicing as component of the spliceosome (By similarity). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0005694 chromosome", "go_biological_process": "GO:0044773 mitotic DNA damage checkpoint signaling;GO:0006396 RNA processing;GO:0043066 negative regulation of apoptotic process;GO:0051301 cell division;GO:0001541 ovarian follicle development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3MHS2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHT3-1", "uniprot_id": [ { "id": "SOLH2_RAT", "url": "https://www.uniprot.org/uniprot/Q3MHT3", "type": "external" } ], "mass": 50669.0, "length": 462, "protein_name": "Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2", "gene_name": "Sohlh2", "organism": "Rat", "refseq_name": "spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2", "refseq_ac": [ { "id": "NP_001030133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030133", "type": "external" } ], "gene_names_uniprotkb": "Sohlh2", "gene_names_refseq": "RGD1304752; Sohlh2", "protein_names_uniprotkb": "Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2", "protein_names_refseq": "spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:619575)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable transcription factor, which may be involved in spermatogenesis and oogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0009994 oocyte differentiation;GO:0001545 primary ovarian follicle growth;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MHT3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MIB4-1", "uniprot_id": [ { "id": "LONP2_RAT", "url": "https://www.uniprot.org/uniprot/Q3MIB4", "type": "external" } ], "mass": 94393.0, "length": 852, "protein_name": "Lon protease homolog 2, peroxisomal", "gene_name": "Lonp2", "organism": "Rat", "refseq_name": "lon protease homolog 2, peroxisomal", "refseq_ac": [ { "id": "NP_001386125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386125", "type": "external" } ], "gene_names_uniprotkb": "Lonp2; LONP2", "gene_names_refseq": "LRRGT00016; Lonp2; RGD1305466", "protein_names_uniprotkb": "Lon protease homolog 2, peroxisomal; 3.4.21.53; Lon protease 2; Lon protease-like protein 2; Peroxisomal Lon protease", "protein_names_refseq": "lon protease 2; lon protease homolog 2, peroxisomal; lon protease-like protein 2; peroxisomal Lon protease homolog 2", "tax_id": 10116, "disease": "", "pathway": " (rno:291922); (R-RNO-9033241)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14561759;38843836", "class_list": "", "function": "ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0002020 protease binding;GO:0004252 serine-type endopeptidase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0016485 protein processing;GO:0006625 protein targeting to peroxisome;GO:0016558 protein import into peroxisome matrix;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins;GO:0031998 regulation of fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3MIB4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ZBA0-1", "uniprot_id": [ { "id": "TCPR1_RAT", "url": "https://www.uniprot.org/uniprot/Q3ZBA0", "type": "external" } ], "mass": 130187.0, "length": 1166, "protein_name": "Tectonin beta-propeller repeat-containing protein 1", "gene_name": "Tecpr1", "organism": "Rat", "refseq_name": "tectonin beta-propeller repeat-containing protein 1", "refseq_ac": [ { "id": "NP_001032268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032268", "type": "external" } ], "gene_names_uniprotkb": "Tecpr1", "gene_names_refseq": "RGD1306873; Tecpr1", "protein_names_uniprotkb": "Tectonin beta-propeller repeat-containing protein 1", "protein_names_refseq": "tectonin beta-propeller repeat-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:304285)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005765 lysosomal membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0016236 macroautophagy;GO:0006914 autophagy;GO:1901096 regulation of autophagosome maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3ZBA0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q45GW3-1", "uniprot_id": [ { "id": "IQUB_RAT", "url": "https://www.uniprot.org/uniprot/Q45GW3", "type": "external" } ], "mass": 91823.0, "length": 790, "protein_name": "IQ motif and ubiquitin-like domain-containing protein", "gene_name": "Iqub", "organism": "Rat", "refseq_name": "IQ motif and ubiquitin-like domain-containing protein", "refseq_ac": [ { "id": "NP_001029302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029302", "type": "external" } ], "gene_names_uniprotkb": "Iqub", "gene_names_refseq": "Iqub; RGD1562359; Trs4", "protein_names_uniprotkb": "IQ motif and ubiquitin-like domain-containing protein; Protein TRS4", "protein_names_refseq": "IQ and ubiquitin-like domain-containing protein; IQ motif and ubiquitin-like domain-containing protein", "tax_id": 10116, "disease": "", "pathway": " (rno:296936)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17635999;17681954;19706271", "class_list": "", "function": "Adapter protein that anchors the radial spoke 1 (RS1) complex to the A microtubule of outer doublet microtubules in axonemes. The triple radial spokes (RS1, RS2 and RS3) are required to modulate beating of the sperm flagellum. May play a role in inhibiting signaling via MAPK1/ERK2 and MAPK3/ERK1. Additionally, may play a role in the functioning of cilia. Not required for the functioning of tracheal or ependymal cilia., [UniProtKB, UniProtKB]; Findings confirm that the Exo70-TC10 complex mainly targets the NGF-induced Cdc42-dependent activation of N-WASP, [RefSeq, PubMed]; SNX9 interacts with dynamin-1 and N-WASP in presynaptic terminals, where it links actin dynamics and synaptic vesicle endocytosis., [RefSeq, PubMed]; These results suggested that Trs4 might be involved in diverse processes of spermiogenesis and/or fertilization through interactions with its multiple binding partners., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZV4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001534 radial spoke;GO:0031514 motile cilium;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum;GO:0097729 9+2 motile cilium", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway;GO:0007618 mating", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q45GW3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q45R42-1", "uniprot_id": [ { "id": "LRRC4_RAT", "url": "https://www.uniprot.org/uniprot/Q45R42", "type": "external" } ], "mass": 72609.0, "length": 652, "protein_name": "Leucine-rich repeat-containing protein 4", "gene_name": "Lrrc4", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 4 precursor", "refseq_ac": [ { "id": "NP_001032413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032413", "type": "external" } ], "gene_names_uniprotkb": "Lrrc4", "gene_names_refseq": "Lrrc4", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 4; NGL-2; Netrin-G2 ligand", "protein_names_refseq": "leucine rich repeat containing 4 protein; leucine-rich repeat-containing protein 4 precursor; leucine-rich repeat-containing protein 4; netrin-G2 ligand; protein NGL-2", "tax_id": 10116, "disease": "", "pathway": " (rno:641521)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1039/D0MO00044B;16980967;20577133;25948265;30782076;34106099", "class_list": "", "function": "Axotomized motoneurons decrease their NGL-2 expression and that the restoration of NGL-2 expression mirrors the restoration of synaptic inputs., [RefSeq, PubMed]; NGL-2 plays a critical role in regulating axon differentiation in hippocampal neurons., [RefSeq, PubMed]; Study shows that locomotor training increases synaptic structure with high NGL-2 expression after spinal cord hemisection. Study identified Lrrc4 (coding NGL-2) as the most highly expressed synapse-related gene in trained compared with nontrained rats after hemisection injury., [RefSeq, PubMed]; Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0045202 synapse", "go_biological_process": "GO:1904861 excitatory synapse assembly;GO:0050808 synapse organization;GO:0050804 modulation of chemical synaptic transmission;GO:0099560 synaptic membrane adhesion;GO:0097119 postsynaptic density protein 95 clustering", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q45R42-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q498C7-1", "uniprot_id": [ { "id": "SIM14_RAT", "url": "https://www.uniprot.org/uniprot/Q498C7", "type": "external" } ], "mass": 10684.0, "length": 99, "protein_name": "Small integral membrane protein 14", "gene_name": "Smim14", "organism": "Rat", "refseq_name": "small integral membrane protein 14", "refseq_ac": [ { "id": "NP_001032881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032881", "type": "external" } ], "gene_names_uniprotkb": "Smim14", "gene_names_refseq": "RGD1311122; Smim14", "protein_names_uniprotkb": "Small integral membrane protein 14", "protein_names_refseq": "small integral membrane protein 14; uncharacterized protein C4orf34 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:364154)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q498C7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q498R1-1", "uniprot_id": [ { "id": "MTRR_RAT", "url": "https://www.uniprot.org/uniprot/Q498R1", "type": "external" } ], "mass": 78025.0, "length": 700, "protein_name": "Methionine synthase reductase", "gene_name": "Mtrr", "organism": "Rat", "refseq_name": "methionine synthase reductase isoform 4", "refseq_ac": [ { "id": "NP_001034092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034092", "type": "external" } ], "gene_names_uniprotkb": "Mtrr", "gene_names_refseq": "MSR; Mtrr", "protein_names_uniprotkb": "Methionine synthase reductase; 1.16.1.8; AqCbl reductase; Aquacobalamin reductase; MSR", "protein_names_refseq": "aqCbl reductase; aquacobalamin reductase; methionine synthase reductase isoform 4; methionine synthase reductase", "tax_id": 10116, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); anencephaly (Disease Ontology:DOID:0060668); spina bifida (Disease Ontology:DOID:0080016); homocystinuria-megaloblastic anemia cblE type (Disease Ontology:DOID:0112255); heart disease (Disease Ontology:DOID:114); Parkinson's disease (Disease Ontology:DOID:14330); heart septal defect (Disease Ontology:DOID:1681); pancreatic cancer (Disease Ontology:DOID:1793); meningioma (Disease Ontology:DOID:3565); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); ulcerative colitis (Disease Ontology:DOID:8577); acute myeloid leukemia (Disease Ontology:DOID:9119); homocystinuria (Disease Ontology:DOID:9263); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:290947); (R-RNO-156581); (R-RNO-1614635); (R-RNO-9759218)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin. Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (By similarity). Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance (By similarity). Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme. Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin; this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZDG8", "ec_number_list": [ { "id": "1.16.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.6", "type": "external" }, { "id": "2.5.1.151", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.151", "type": "external" }, { "id": "1.16.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.8", "type": "external" }, { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0070402 NADPH binding;GO:0010181 FMN binding;GO:0003958 NADPH-hemoprotein reductase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009235 cobalamin metabolic process;GO:0046655 folic acid metabolic process;GO:0043418 homocysteine catabolic process;GO:0009086 methionine biosynthetic process;GO:0050667 homocysteine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q498R1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q499R0-1", "uniprot_id": [ { "id": "Z518A_RAT", "url": "https://www.uniprot.org/uniprot/Q499R0", "type": "external" } ], "mass": 165539.0, "length": 1478, "protein_name": "Zinc finger protein 518A", "gene_name": "Znf518a", "organism": "Rat", "refseq_name": "zinc finger protein 518A", "refseq_ac": [ { "id": "NP_001025209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025209", "type": "external" } ], "gene_names_uniprotkb": "Znf518a; Zfp518a; Zfp518; Znf518", "gene_names_refseq": "RGD1305314; Zfp518a; Znf518a; Znf518", "protein_names_uniprotkb": "Zinc finger protein 518A", "protein_names_refseq": "zinc finger protein 518A; zinc finger protein 518", "tax_id": 10116, "disease": "", "pathway": " (rno:309478)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Through its association with the EHMT1-EHMT2/G9A and PRC2/EED-EZH2 histone methyltransferase complexes may function in gene silencing, regulating repressive post-translational methylation of histone tails at promoters of target genes., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q499R0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZT0-1", "uniprot_id": [ { "id": "STML2_RAT", "url": "https://www.uniprot.org/uniprot/Q4FZT0", "type": "external" } ], "mass": 38414.0, "length": 353, "protein_name": "Stomatin-like protein 2, mitochondrial", "gene_name": "Stoml2", "organism": "Rat", "refseq_name": "stomatin-like protein 2, mitochondrial", "refseq_ac": [ { "id": "NP_001026816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026816", "type": "external" } ], "gene_names_uniprotkb": "Stoml2", "gene_names_refseq": "Stoml2", "protein_names_uniprotkb": "Stomatin-like protein 2, mitochondrial; SLP-2", "protein_names_refseq": "SLP-2; stomatin (Epb7.2)-like 2; stomatin-like protein 2, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:298203); (R-RNO-8949664); (R-RNO-9840373)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "28100784", "class_list": "", "function": "Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051020 GTPase binding;GO:0042608 T cell receptor binding;GO:1901612 cardiolipin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0035710 CD4-positive, alpha-beta T cell activation;GO:0010876 lipid localization;GO:1990046 stress-induced mitochondrial fusion;GO:0051259 protein complex oligomerization;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4FZT0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZX7-1", "uniprot_id": [ { "id": "SRPRB_RAT", "url": "https://www.uniprot.org/uniprot/Q4FZX7", "type": "external" } ], "mass": 29569.0, "length": 269, "protein_name": "Signal recognition particle receptor subunit beta", "gene_name": "Srprb", "organism": "Rat", "refseq_name": "signal recognition particle receptor subunit beta", "refseq_ac": [ { "id": "NP_001013270", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013270", "type": "external" } ], "gene_names_uniprotkb": "Srprb", "gene_names_refseq": "Ab2-417; Ba1-667; Cc1-8; Srprb", "protein_names_uniprotkb": "Signal recognition particle receptor subunit beta; SR-beta", "protein_names_refseq": "SR-beta; SRP receptor beta subunit; signal recognition particle receptor subunit beta; signal recognition particle receptor, B subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:300965)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18683930", "class_list": "", "function": "Component of the signal recognition particle (SRP) complex receptor (SR) (By similarity). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). May mediate the membrane association of SR (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005785 signal recognition particle receptor complex;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0045047 protein targeting to ER", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4FZX7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLN0-1", "uniprot_id": [ { "id": "SDCB2_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLN0", "type": "external" } ], "mass": 31965.0, "length": 296, "protein_name": "Syntenin-2", "gene_name": "Sdcbp2", "organism": "Rat", "refseq_name": "syntenin-2", "refseq_ac": [ { "id": "NP_001020863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020863", "type": "external" } ], "gene_names_uniprotkb": "Sdcbp2", "gene_names_refseq": "Sdcbp2", "protein_names_uniprotkb": "Syntenin-2; Syndecan-binding protein 2", "protein_names_refseq": "syndecan binding protein (syntenin) 2; syntenin-2", "tax_id": 10116, "disease": "", "pathway": " (rno:311532)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11152476", "class_list": "", "function": "Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KLN0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLY8-1", "uniprot_id": [ { "id": "STPG1_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLY8", "type": "external" } ], "mass": 37534.0, "length": 341, "protein_name": "O(6)-methylguanine-induced apoptosis 2", "gene_name": "Stpg1", "organism": "Rat", "refseq_name": "O(6)-methylguanine-induced apoptosis 2", "refseq_ac": [ { "id": "NP_001020943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020943", "type": "external" } ], "gene_names_uniprotkb": "Stpg1", "gene_names_refseq": "Mapo2; Stpg1", "protein_names_uniprotkb": "O(6)-methylguanine-induced apoptosis 2; MAPO2; Sperm-tail PG-rich repeat-containing protein 1", "protein_names_refseq": "O(6)-methylguanine-induced apoptosis 2; O6-methylguanine-induced apoptosis 2; UPF0490 protein C1orf201 homolog; sperm-tail PG-rich repeat-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:500566)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005737 cytoplasm", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KLY8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM92-1", "uniprot_id": [ { "id": "PUS1_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM92", "type": "external" } ], "mass": 47515.0, "length": 423, "protein_name": "Pseudouridylate synthase 1 homolog", "gene_name": "Pus1", "organism": "Rat", "refseq_name": "pseudouridylate synthase 1 homolog", "refseq_ac": [ { "id": "NP_001020734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020734", "type": "external" } ], "gene_names_uniprotkb": "Pus1", "gene_names_refseq": "Pus1", "protein_names_uniprotkb": "Pseudouridylate synthase 1 homolog; 5.4.99.-; 5.4.99.12; tRNA pseudouridine synthase 1; tRNA pseudouridine(38-40) synthase; tRNA pseudouridylate synthase I; tRNA-uridine isomerase I", "protein_names_refseq": "pseudouridylate synthase 1 homolog; pseudouridylate synthase 1; tRNA pseudouridine synthase 1; tRNA pseudouridine synthase A, mitochondrial; tRNA pseudouridine(38-40) synthase; tRNA pseudouridylate synthase I; tRNA-uridine isomerase I", "tax_id": 10116, "disease": "myopathy, lactic acidosis, and sideroblastic anemia (Disease Ontology:DOID:0080099); myopathy, lactic acidosis, and sideroblastic anemia 1 (Disease Ontology:DOID:0111185)", "pathway": " (rno:304567)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.4.99.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.12", "type": "external" }, { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" }, { "id": "5.4.99.25", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.25", "type": "external" } ], "go_molecular_function": "GO:0002153 steroid receptor RNA activator RNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0000049 tRNA binding;GO:0009982 pseudouridine synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0031119 tRNA pseudouridine synthesis;GO:0006397 mRNA processing;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008380 RNA splicing;GO:1990481 mRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KM92-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KSH7-1", "uniprot_id": [ { "id": "MP2K7_RAT", "url": "https://www.uniprot.org/uniprot/Q4KSH7", "type": "external" } ], "mass": 47536.0, "length": 419, "protein_name": "Dual specificity mitogen-activated protein kinase kinase 7", "gene_name": "Map2k7", "organism": "Rat", "refseq_name": "dual specificity mitogen-activated protein kinase kinase 7 isoform 1", "refseq_ac": [ { "id": "NP_001020596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020596", "type": "external" } ], "gene_names_uniprotkb": "Map2k7", "gene_names_refseq": "JNKK; Jnkk2; Map2k7; Mapkk7; Mek7; Mkk7", "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase 7; 2.7.12.2; JNK kinase 2; JNK-activating kinase 2; JNKK 2; MAP kinase kinase 7; MAPK/ERK kinase 7; MAPKK 7; MEK 7; c-Jun N-terminal kinase kinase 2", "protein_names_refseq": "JNK kinase 2; JNK-activating kinase 2; JNKK 2; MAP kinase kinase 7; MAPK/ERK kinase 7; MAPKK 7; MEK 7; c-Jun N-terminal kinase kinase 2; dual specificity mitogen-activated protein kinase kinase 7 isoform 1; dual specificity mitogen-activated protein kinase kinase 7", "tax_id": 10116, "disease": "heart disease (Disease Ontology:DOID:114); colon adenocarcinoma (Disease Ontology:DOID:234); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); schizophrenia (Disease Ontology:DOID:5419); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (rno:363855); (R-RNO-2559580); (R-RNO-2871796); (R-RNO-450321)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10051439;14575811;17496909;20801953;21333379", "class_list": "", "function": "Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0008545 JUN kinase kinase activity;GO:0000287 magnesium ion binding;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:2000671 regulation of motor neuron apoptotic process;GO:0072709 cellular response to sorbitol;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0006970 response to osmotic stress", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q4KSH7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QR80-1", "uniprot_id": [ { "id": "RT25_RAT", "url": "https://www.uniprot.org/uniprot/Q4QR80", "type": "external" } ], "mass": 19775.0, "length": 171, "protein_name": "Small ribosomal subunit protein mS25", "gene_name": "Mrps25", "organism": "Rat", "refseq_name": "small ribosomal subunit protein mS25", "refseq_ac": [ { "id": "NP_001020579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020579", "type": "external" } ], "gene_names_uniprotkb": "Mrps25", "gene_names_refseq": "Mrps25; Shd10", "protein_names_uniprotkb": "Small ribosomal subunit protein mS25; 28S ribosomal protein S25, mitochondrial; MRP-S25; S25mt", "protein_names_refseq": "28S ribosomal protein S25, mitochondrial; MRP-S25; S25mt; small ribosomal subunit protein mS25", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency 50 (Disease Ontology:DOID:0112111)", "pathway": " (rno:297459); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "12161272", "class_list": "", "function": "Sequencing analyses showed that SHD10 shared a 94% (547/581) homology with mouse EST BI687817, but its biological function has not been reported. SHD11 shared a 91% (512/562) homology with mouse EST BG172336., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4QR80-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QRB2-1", "uniprot_id": [ { "id": "SYF2_RAT", "url": "https://www.uniprot.org/uniprot/Q4QRB2", "type": "external" } ], "mass": 28712.0, "length": 242, "protein_name": "Pre-mRNA-splicing factor SYF2", "gene_name": "Syf2", "organism": "Rat", "refseq_name": "pre-mRNA-splicing factor SYF2", "refseq_ac": [ { "id": "NP_596908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596908", "type": "external" } ], "gene_names_uniprotkb": "Syf2", "gene_names_refseq": "Gcipip; P29; Syf2", "protein_names_uniprotkb": "Pre-mRNA-splicing factor SYF2", "protein_names_refseq": "GCIP-interacting protein p29; SYF2 homolog, RNA splicing factor; pre-mRNA-splicing factor SYF2", "tax_id": 10116, "disease": "encephalitis (Disease Ontology:DOID:9588)", "pathway": " (rno:170933); (R-RNO-72163)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12473062;24301298;24962097;25944718", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the spliceosome., [UniProtKB, UniProtKB]; SYF2 protein expression was dramatically upregulated after retinal damage., [RefSeq, PubMed]; The upregulation of SYF2 was associated with Schwann cell differentiation and migration following sciatic nerve crush., [RefSeq, PubMed]; This study shows that SYF2 was significantly increased in the rat cerebral cortex after LPS injection, suggesting that SYF2 might be involved in the pathological processes of astrocyte proliferation and neuronal apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91Y33", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071014 post-mRNA release spliceosomal complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0008284 positive regulation of cell population proliferation;GO:0007369 gastrulation;GO:0000398 mRNA splicing, via spliceosome;GO:0048568 embryonic organ development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4QRB2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V887-1", "uniprot_id": [ { "id": "S39A6_RAT", "url": "https://www.uniprot.org/uniprot/Q4V887", "type": "external" } ], "mass": 83231.0, "length": 741, "protein_name": "Zinc transporter ZIP6", "gene_name": "Slc39a6", "organism": "Rat", "refseq_name": "zinc transporter ZIP6 precursor", "refseq_ac": [ { "id": "NP_001019916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019916", "type": "external" } ], "gene_names_uniprotkb": "Slc39a6; Zip6", "gene_names_refseq": "Slc39a6", "protein_names_uniprotkb": "Zinc transporter ZIP6; Solute carrier family 39 member 6; ZIP-6; Zrt- and Irt-like protein 6", "protein_names_refseq": "ZIP-6; solute carrier family 39 (metal ion transporter), member 6; solute carrier family 39 (zinc transporter), member 6; zinc transporter ZIP6 precursor; zinc transporter ZIP6; zrt- and Irt-like protein 6", "tax_id": 10116, "disease": "", "pathway": " (rno:291733); (R-RNO-442380)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15867272;22673903;29393594;38843836", "class_list": "", "function": "Liv-1 (SLC39A6)is localized to the plasma membrane in neurons, suggesting that it plays a role in Zn uptake into neurons, [RefSeq, PubMed]; Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT) (By similarity). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (By similarity). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essential role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis. Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes. Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0140410 monoatomic cation:bicarbonate symporter activity;GO:0046873 metal ion transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0016324 apical plasma membrane;GO:0031258 lamellipodium membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0046649 lymphocyte activation;GO:0050852 T cell receptor signaling pathway;GO:0001837 epithelial to mesenchymal transition;GO:0006882 intracellular zinc ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q4V887-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V892-1", "uniprot_id": [ { "id": "SIGIR_RAT", "url": "https://www.uniprot.org/uniprot/Q4V892", "type": "external" } ], "mass": 46171.0, "length": 409, "protein_name": "Single Ig IL-1-related receptor", "gene_name": "Ano9; Sigirr", "organism": "Rat", "refseq_name": "single Ig IL-1-related receptor isoform 1", "refseq_ac": [ { "id": "NP_001020058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020058", "type": "external" } ], "gene_names_uniprotkb": "Ano9; Sigirr; RGD1560565; Sigirr", "gene_names_refseq": "RGD1306732; Sigirr", "protein_names_uniprotkb": "Single Ig IL-1-related receptor; Single Ig IL-1R-related molecule; Single immunoglobulin domain-containing IL1R-related protein; TIR8; Toll/interleukin-1 receptor 8", "protein_names_refseq": "TIR8; single Ig IL-1-related receptor isoform 1; single Ig IL-1-related receptor; single Ig IL-1R-related molecule; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; single immunoglobulin domain-containing IL1R-related protein; toll/interleukin-1 receptor 8", "tax_id": 10116, "disease": "", "pathway": " (rno:309106); (rno:499287); (R-RNO-2672351)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "22673903;28056921", "class_list": "", "function": "Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This study demonstrated B. adolescentis prevents NEC in preterm neonatal rats and that the mechanism for this action might be associated with the alteration of TLR4, TOLLIP, and SIGIRR expression. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019869 chloride channel inhibitor activity;GO:0005262 calcium channel activity;GO:0015267 channel activity;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:2000660 negative regulation of interleukin-1-mediated signaling pathway;GO:0007166 cell surface receptor signaling pathway;GO:0006953 acute-phase response;GO:0032682 negative regulation of chemokine production", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4V892-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V896-1", "uniprot_id": [ { "id": "SNX15_RAT", "url": "https://www.uniprot.org/uniprot/Q4V896", "type": "external" } ], "mass": 37905.0, "length": 338, "protein_name": "Sorting nexin-15", "gene_name": "Snx15", "organism": "Rat", "refseq_name": "sorting nexin-15", "refseq_ac": [ { "id": "NP_001019923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019923", "type": "external" } ], "gene_names_uniprotkb": "Snx15", "gene_names_refseq": "Snx15", "protein_names_uniprotkb": "Sorting nexin-15", "protein_names_refseq": "sorting nexin-15", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:293691)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V896-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8A9-1", "uniprot_id": [ { "id": "SG196_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8A9", "type": "external" } ], "mass": 40054.0, "length": 349, "protein_name": "Protein O-mannose kinase", "gene_name": "Pomk", "organism": "Rat", "refseq_name": "protein O-mannose kinase", "refseq_ac": [ { "id": "NP_001020054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020054", "type": "external" } ], "gene_names_uniprotkb": "Pomk; Sgk196", "gene_names_refseq": "Pomk; RGD1310810; Sgk196", "protein_names_uniprotkb": "Protein O-mannose kinase; 2.7.1.183; POMK; Protein kinase-like protein SgK196; Sugen kinase 196", "protein_names_refseq": "probable inactive protein kinase-like protein SgK196; protein O-mannose kinase; sugen kinase 196", "tax_id": 10116, "disease": "congenital muscular dystrophy-dystroglycanopathy type A12 (Disease Ontology:DOID:0111235); muscular dystrophy-dystroglycanopathy type C12 (Disease Ontology:DOID:0112381); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (rno:306549); (R-RNO-8932505)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycan-modifying enzyme;glycogene", "function": "Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.183", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.183", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0019200 carbohydrate kinase activity;GO:0016773 phosphotransferase activity, alcohol group as acceptor", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007611 learning or memory;GO:0050905 neuromuscular process;GO:0006493 protein O-linked glycosylation;GO:0019233 sensory perception of pain;GO:0007420 brain development", "synthesized_glycan_count": 17, "hit_score": 0.1, "record_id": "Q4V8A9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010000.001.10010", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8B8-1", "uniprot_id": [ { "id": "TYW2_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8B8", "type": "external" } ], "mass": 49387.0, "length": 437, "protein_name": "tRNA wybutosine-synthesizing protein 2 homolog", "gene_name": "Tyw2", "organism": "Rat", "refseq_name": "tRNA wybutosine-synthesizing protein 2 homolog", "refseq_ac": [ { "id": "NP_001116448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116448", "type": "external" } ], "gene_names_uniprotkb": "Tyw2; Trmt12", "gene_names_refseq": "RGD1307127; Trmt12; Tyw2", "protein_names_uniprotkb": "tRNA wybutosine-synthesizing protein 2 homolog; 2.5.1.114; tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase; tRNA-yW-synthesizing protein 2", "protein_names_refseq": "alpha-amino-alpha-carboxypropyl transferase TYW2; tRNA methyltransferase 12; tRNA wybutosine-synthesizing protein 2 homolog; tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase; tRNA-yW-synthesizing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:314999)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AXV3", "ec_number_list": [ { "id": "2.5.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.114", "type": "external" } ], "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:0102522 tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0030488 tRNA methylation;GO:0031591 wybutosine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8B8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8C2-1", "uniprot_id": [ { "id": "ZW10_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8C2", "type": "external" } ], "mass": 87967.0, "length": 777, "protein_name": "Centromere/kinetochore protein zw10 homolog", "gene_name": "Zw10", "organism": "Rat", "refseq_name": "centromere/kinetochore protein zw10 homolog isoform 1", "refseq_ac": [ { "id": "NP_001019972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019972", "type": "external" } ], "gene_names_uniprotkb": "Zw10", "gene_names_refseq": "Zw10", "protein_names_uniprotkb": "Centromere/kinetochore protein zw10 homolog", "protein_names_refseq": "ZW10 homolog, centromere/kinetochore protein; ZW10, kinetochore associated, homolog; centromere/kinetochore protein zw10 homolog isoform 1; centromere/kinetochore protein zw10 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:363059); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-6811434); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "17560939", "class_list": "", "function": "Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (By similarity)., [UniProtKB, UniProtKB]; Targeting of ZW10 to the perinuclear Golgi region was found to depend on the perinuclear accumulation of dynactin, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005828 kinetochore microtubule;GO:1990423 RZZ complex;GO:0070939 Dsl1/NZR complex;GO:0000922 spindle pole;GO:0005634 nucleus", "go_biological_process": "GO:0015031 protein transport;GO:0051301 cell division;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0007080 mitotic metaphase chromosome alignment", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8C2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8F9-1", "uniprot_id": [ { "id": "HSDL2_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8F9", "type": "external" } ], "mass": 58344.0, "length": 524, "protein_name": "Hydroxysteroid dehydrogenase-like protein 2", "gene_name": "Hsdl2", "organism": "Rat", "refseq_name": "hydroxysteroid dehydrogenase-like protein 2", "refseq_ac": [ { "id": "NP_001020868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020868", "type": "external" } ], "gene_names_uniprotkb": "Hsdl2", "gene_names_refseq": "Hsdl2; RGD1305387", "protein_names_uniprotkb": "Hydroxysteroid dehydrogenase-like protein 2; 1.-.-.-", "protein_names_refseq": "hydroxysteroid dehydrogenase-like protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:313200)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "28100784;29393594", "class_list": "", "function": "Has apparently no steroid dehydrogenase activity. Controls bile acid (BA) and lipid metabolism in response to nutritional cues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome", "go_biological_process": "GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4V8F9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8G8-1", "uniprot_id": [ { "id": "TEKT3_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8G8", "type": "external" } ], "mass": 56416.0, "length": 490, "protein_name": "Tektin-3", "gene_name": "Tekt3", "organism": "Rat", "refseq_name": "tektin-3", "refseq_ac": [ { "id": "NP_001019910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019910", "type": "external" } ], "gene_names_uniprotkb": "Tekt3", "gene_names_refseq": "Tekt3", "protein_names_uniprotkb": "Tektin-3", "protein_names_refseq": "tektin-3", "tax_id": 10116, "disease": "spermatogenic failure 81 (Disease Ontology:DOID:0070580)", "pathway": " (rno:287392)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19423663;21744413", "class_list": "", "function": "Immunomicroscopy revealed that TEKT3 was predominantly associated with the surface of mitochondria and outer dense fibers in the middle piece. In addition, TEKT3 was found at the equatorial segment region of the acrosome membrane in sperm heads., [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). Required for normal sperm mobility (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005737 cytoplasm;GO:0015630 microtubule cytoskeleton;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0060378 regulation of brood size;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4V8G8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8K4-1", "uniprot_id": [ { "id": "S2539_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8K4", "type": "external" } ], "mass": 39235.0, "length": 359, "protein_name": "Mitochondrial glutathione transporter SLC25A39", "gene_name": "Slc25a39", "organism": "Rat", "refseq_name": "mitochondrial glutathione transporter SLC25A39", "refseq_ac": [ { "id": "NP_001019963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019963", "type": "external" } ], "gene_names_uniprotkb": "Slc25a39", "gene_names_refseq": "RGD1306193; Slc25a39", "protein_names_uniprotkb": "Mitochondrial glutathione transporter SLC25A39; Solute carrier family 25 member 39", "protein_names_refseq": "mitochondrial glutathione transporter SLC25A39; probable mitochondrial glutathione transporter SLC25A39", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:360636)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0034634 glutathione transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0071281 cellular response to iron ion;GO:0006783 heme biosynthetic process;GO:1990542 mitochondrial transmembrane transport;GO:0160007 glutathione import into mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8K4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q504L7-1", "uniprot_id": [ { "id": "ZN574_RAT", "url": "https://www.uniprot.org/uniprot/Q504L7", "type": "external" } ], "mass": 99355.0, "length": 898, "protein_name": "Zinc finger protein 574", "gene_name": "Znf574", "organism": "Rat", "refseq_name": "zinc finger protein 574", "refseq_ac": [ { "id": "NP_001019429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019429", "type": "external" } ], "gene_names_uniprotkb": "Znf574; Zfp574", "gene_names_refseq": "Zfp574; Znf574", "protein_names_uniprotkb": "Zinc finger protein 574", "protein_names_refseq": "zinc finger protein 574", "tax_id": 10116, "disease": "", "pathway": " (rno:308434)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of a ribosome quality control that mediates surveillance of ribosome assembly and promotes degradation of ribosomes with assembly defects., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0032502 developmental process;GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process;GO:0042256 cytosolic ribosome assembly;GO:0090069 regulation of ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q504L7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q561Q8-1", "uniprot_id": [ { "id": "MED4_RAT", "url": "https://www.uniprot.org/uniprot/Q561Q8", "type": "external" } ], "mass": 29826.0, "length": 270, "protein_name": "Mediator of RNA polymerase II transcription subunit 4", "gene_name": "Med4", "organism": "Rat", "refseq_name": "mediator of RNA polymerase II transcription subunit 4", "refseq_ac": [ { "id": "NP_001019427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019427", "type": "external" } ], "gene_names_uniprotkb": "Med4; MED4", "gene_names_refseq": "Med4; Vdrip", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 4; Mediator complex subunit 4", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 4; mediator of RNA polymerase II transcription, subunit 4 homolog; vitamin D receptor interacting protein", "tax_id": 10116, "disease": "cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (rno:306030); (R-RNO-9841922)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046966 nuclear thyroid hormone receptor binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q561Q8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q568Z4-1", "uniprot_id": [ { "id": "SPCS3_RAT", "url": "https://www.uniprot.org/uniprot/Q568Z4", "type": "external" } ], "mass": 20160.0, "length": 180, "protein_name": "Signal peptidase complex subunit 3", "gene_name": "Spcs3", "organism": "Rat", "refseq_name": "signal peptidase complex subunit 3", "refseq_ac": [ { "id": "NP_001019438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019438", "type": "external" } ], "gene_names_uniprotkb": "Spcs3", "gene_names_refseq": "Arxes1; Spcs3", "protein_names_uniprotkb": "Signal peptidase complex subunit 3; Microsomal signal peptidase 22/23 kDa subunit; SPC22/23; SPase 22/23 kDa subunit", "protein_names_refseq": "SPC22/23; SPase 22 kDa subunit; SPase 22/23 kDa subunit; microsomal signal peptidase 22/23 kDa subunit; microsomal signal peptidase 23 kDa subunit; signal peptidase complex subunit 3", "tax_id": 10116, "disease": "", "pathway": " (rno:317409)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005787 signal peptidase complex", "go_biological_process": "GO:0045444 fat cell differentiation;GO:0045047 protein targeting to ER;GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q568Z4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q568Z6-1", "uniprot_id": [ { "id": "IST1_RAT", "url": "https://www.uniprot.org/uniprot/Q568Z6", "type": "external" } ], "mass": 39942.0, "length": 366, "protein_name": "IST1 homolog", "gene_name": "Ist1", "organism": "Rat", "refseq_name": "IST1 homolog", "refseq_ac": [ { "id": "NP_001017454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017454", "type": "external" } ], "gene_names_uniprotkb": "Ist1", "gene_names_refseq": "CHMP8; Ist1; RGD1307799", "protein_names_uniprotkb": "IST1 homolog; CHMP8; Charged multivesicular body protein 8", "protein_names_refseq": "IST1 homolog; IST1, ESCRT-III associated factor; MAPK activating protein PM28; charged multivesicular body protein 8; increased sodium tolerance 1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:307833); (R-RNO-6798695); (R-RNO-9668328)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (By similarity). Is required for efficient abscission during cytokinesis (By similarity). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (By similarity). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (By similarity). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (By similarity). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0090541 MIT domain binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005813 centrosome;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0051301 cell division;GO:0045184 establishment of protein localization;GO:0008104 intracellular protein localization;GO:0045862 positive regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q568Z6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q569C3-1", "uniprot_id": [ { "id": "UBP1_RAT", "url": "https://www.uniprot.org/uniprot/Q569C3", "type": "external" } ], "mass": 87329.0, "length": 784, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 1", "gene_name": "Usp1", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 1", "refseq_ac": [ { "id": "NP_001015015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015015", "type": "external" } ], "gene_names_uniprotkb": "Usp1", "gene_names_refseq": "Usp1", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 1; 3.4.19.12; Deubiquitinating enzyme 1; Ubiquitin thioesterase 1; Ubiquitin-specific-processing protease 1", "protein_names_refseq": "deubiquitinating enzyme 1; ubiquitin carboxyl-terminal hydrolase 1; ubiquitin specific protease 1; ubiquitin thioesterase 1; ubiquitin thiolesterase 1; ubiquitin-specific-processing protease 1", "tax_id": 10116, "disease": "Fanconi anemia (Disease Ontology:DOID:13636)", "pathway": " (rno:313387); (R-RNO-110314); (R-RNO-6783310)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "22673903;36859264", "class_list": "", "function": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB]; Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity., [UniProtKB, UniProtKB]; The promotive role of USP1 inhibition in coordinating osteogenic differentiation and fracture healing during nonunion. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008233 peptidase activity;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:1905368 peptidase complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0001501 skeletal system development;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q569C3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q587K4-1", "uniprot_id": [ { "id": "LRC73_RAT", "url": "https://www.uniprot.org/uniprot/Q587K4", "type": "external" } ], "mass": 33377.0, "length": 316, "protein_name": "Leucine-rich repeat-containing protein 73", "gene_name": "Lrrc73", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 73", "refseq_ac": [ { "id": "NP_001019531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019531", "type": "external" } ], "gene_names_uniprotkb": "Lrrc73; Nod3l", "gene_names_refseq": "Lrrc73; nod3l", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 73; NOD3-like protein", "protein_names_refseq": "NOD3-like protein; leucine-rich repeat-containing protein 73; uncharacterized protein C6orf154 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:501101)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19103603", "class_list": "", "function": "Expression of Nod3l in the rat pineal gland exhibits a robust daily rhythm, with ~20-fold higher values at night. Expression is controlled by an adrenergic cyclic AMP mechanism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1A5L6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q587K4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJM8-1", "uniprot_id": [ { "id": "ZNT7_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJM8", "type": "external" } ], "mass": 41774.0, "length": 378, "protein_name": "Zinc transporter 7", "gene_name": "Slc30a7", "organism": "Rat", "refseq_name": "zinc transporter 7", "refseq_ac": [ { "id": "NP_001178644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178644", "type": "external" } ], "gene_names_uniprotkb": "Slc30a7; Znt7", "gene_names_refseq": "Slc30a7", "protein_names_uniprotkb": "Zinc transporter 7; Solute carrier family 30 member 7", "protein_names_refseq": "solute carrier family 30 (zinc transporter), member 7; zinc transporter 7; znT-7", "tax_id": 10116, "disease": "carcinoma (Disease Ontology:DOID:305)", "pathway": " (rno:310801)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "23104082;27147436;28232492;29307859;29627824;37196548", "class_list": "", "function": "Data suggest that the ZnT7 (Slc30A7) may account for the inhibition of high glucose (HG)-induced epithelial-to-mesenchymal transition (EMT) in peritoneal mesothelial cells (PMCs)., [RefSeq, PubMed]; Evidence that ZnT7 has a protective effect over epithelial-to-mesenchymal transition (EMT) of renal tubular epithelial cells in diabetic nephropathy and suggests that the inhibition of HG-induced EMT may be achieved through the MAPK/ERK and TGF-beta/Smad pathways., [RefSeq, PubMed]; Markedly increased mRNA and protein levels of ZIP7 were observed in ventricular cardiomyocytes from diabetic rats or high-glucose-treated H9c2 cells while ZnT7 expression was low., [RefSeq, PubMed]; Overall, this study provides an important description about the role of ZIP7 and ZnT7, localized to both mitochondria and sarco(endo)plasmic reticulum and contribute to cellular Zn(2+)-muffling between cellular-compartments in hyperglycemia or hypertrophic cardiomyocytes via affecting sarco(endo)plasmic reticulum-mitochondria coupling., [RefSeq, PubMed]; Overexpression of Slc30a7/ZnT7 increases the mitochondrial matrix levels of labile Zn[2+] and modifies histone modification in hyperinsulinemic cardiomyoblasts., [RefSeq, PubMed]; The recurrent seizures plus normal diet group showed worse performances in neurological reflex tests and reduced latencies to myoclonic seizures induced by penicillin compared with the control, which was concomitant with altered expressions of ZnT-7, MT-1, MT-2, and ZIP7., [RefSeq, PubMed]; Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:1990674 Golgi cis cisterna membrane;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006829 zinc ion transport;GO:0006882 intracellular zinc ion homeostasis;GO:1904257 zinc ion import into Golgi lumen", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5BJM8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJP3-1", "uniprot_id": [ { "id": "UFM1_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJP3", "type": "external" } ], "mass": 9118.0, "length": 85, "protein_name": "Ubiquitin-fold modifier 1", "gene_name": "Ufm1", "organism": "Rat", "refseq_name": "ubiquitin-fold modifier 1", "refseq_ac": [ { "id": "NP_001119552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119552", "type": "external" } ], "gene_names_uniprotkb": "Ufm1", "gene_names_refseq": "RGD1304890; Ufm1", "protein_names_uniprotkb": "Ubiquitin-fold modifier 1", "protein_names_refseq": "ubiquitin-fold modifier 1", "tax_id": 10116, "disease": "autosomal recessive cerebellar ataxia (Disease Ontology:DOID:0050950); hypomyelinating leukodystrophy 14 (Disease Ontology:DOID:0080296)", "pathway": " (rno:365797)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. Ufmylation is involved in various processes, such as ribosome recycling, response to DNA damage, transcription or reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007420 brain development;GO:0042308 negative regulation of protein import into nucleus;GO:0034976 response to endoplasmic reticulum stress;GO:0071569 protein ufmylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJP3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJS9-1", "uniprot_id": [ { "id": "MORN4_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJS9", "type": "external" } ], "mass": 16238.0, "length": 146, "protein_name": "MORN repeat-containing protein 4", "gene_name": "Morn4", "organism": "Rat", "refseq_name": "MORN repeat-containing protein 4", "refseq_ac": [ { "id": "NP_001020146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020146", "type": "external" } ], "gene_names_uniprotkb": "Morn4", "gene_names_refseq": "Morn4; RGD1307336", "protein_names_uniprotkb": "MORN repeat-containing protein 4", "protein_names_refseq": "MORN repeat-containing protein 4; neuroprotective protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:293950)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0042995 cell projection;GO:0032433 filopodium tip;GO:0032426 stereocilium tip;GO:0032420 stereocilium", "go_biological_process": "GO:0048678 response to axon injury", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJS9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJY4-1", "uniprot_id": [ { "id": "JOS1_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJY4", "type": "external" } ], "mass": 23178.0, "length": 202, "protein_name": "Josephin-1", "gene_name": "Josd1", "organism": "Rat", "refseq_name": "josephin-1", "refseq_ac": [ { "id": "NP_001020180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020180", "type": "external" } ], "gene_names_uniprotkb": "Josd1", "gene_names_refseq": "Josd1; RGD1305388", "protein_names_uniprotkb": "Josephin-1; 3.4.19.12; Josephin domain-containing protein 1", "protein_names_refseq": "josephin domain-containing protein 1; josephin-1", "tax_id": 10116, "disease": "", "pathway": " (rno:315134); (R-RNO-5689877)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006897 endocytosis;GO:0016579 protein deubiquitination;GO:0061024 membrane organization;GO:0048870 cell motility", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJY4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK67-1", "uniprot_id": [ { "id": "TIFAB_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK67", "type": "external" } ], "mass": 16666.0, "length": 147, "protein_name": "TRAF-interacting protein with FHA domain-containing protein B", "gene_name": "Tifab", "organism": "Rat", "refseq_name": "TRAF-interacting protein with FHA domain-containing protein B", "refseq_ac": [ { "id": "NP_001020200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020200", "type": "external" } ], "gene_names_uniprotkb": "Tifab", "gene_names_refseq": "RGD1311681; Tifab", "protein_names_uniprotkb": "TRAF-interacting protein with FHA domain-containing protein B; TIFA-like protein", "protein_names_refseq": "TIFA inhibitor B; TIFA-like protein; TRAF-interacting protein with FHA domain-containing protein B; TRAF-interacting protein with forkhead-associated domain, family member B", "tax_id": 10116, "disease": "", "pathway": " (rno:364674)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990381 ubiquitin-specific protease binding;GO:0035800 deubiquitinase activator activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0048806 genitalia development;GO:0030432 peristalsis;GO:0031223 auditory behavior;GO:0048634 regulation of muscle organ development;GO:0071626 mastication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK67-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK68-1", "uniprot_id": [ { "id": "SNPC3_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK68", "type": "external" } ], "mass": 46230.0, "length": 407, "protein_name": "snRNA-activating protein complex subunit 3", "gene_name": "Snapc3", "organism": "Rat", "refseq_name": "snRNA-activating protein complex subunit 3", "refseq_ac": [ { "id": "NP_001013230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013230", "type": "external" } ], "gene_names_uniprotkb": "Snapc3", "gene_names_refseq": "Snapc3", "protein_names_uniprotkb": "snRNA-activating protein complex subunit 3; SNAPc subunit 3; Small nuclear RNA-activating complex polypeptide 3", "protein_names_refseq": "SNAPc subunit 3; snRNA-activating protein complex subunit 3", "tax_id": 10116, "disease": "", "pathway": " (rno:362537); (R-RNO-6807505); (R-RNO-76071)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003681 bent DNA binding;GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0019185 snRNA-activating protein complex", "go_biological_process": "GO:0042795 snRNA transcription by RNA polymerase II;GO:0042796 snRNA transcription by RNA polymerase III;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK68-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EB68-1", "uniprot_id": [ { "id": "KAD6_RAT", "url": "https://www.uniprot.org/uniprot/Q5EB68", "type": "external" } ], "mass": 19944.0, "length": 172, "protein_name": "Adenylate kinase isoenzyme 6", "gene_name": "Ak6", "organism": "Rat", "refseq_name": "adenylate kinase isoenzyme 6", "refseq_ac": [ { "id": "NP_001012481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012481", "type": "external" } ], "gene_names_uniprotkb": "Ak6; Cinap", "gene_names_refseq": "AK/ATPase; Ak6", "protein_names_uniprotkb": "Adenylate kinase isoenzyme 6; 2.7.4.3; AK/ATPase; AK6; Coilin-interacting nuclear ATPase protein; Dual activity adenylate kinase/ATPase", "protein_names_refseq": "ATP-AMP transphosphorylase 6; adenylate kinase isoenzyme 6; coilin-interacting nuclear ATPase protein; dual activity adenylate kinase/ATPase", "tax_id": 10116, "disease": "", "pathway": " (rno:102238592); (R-RNO-499943)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Also has ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis. May be involved in regulation of Cajal body (CB) formation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6XB81", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" } ], "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0015030 Cajal body", "go_biological_process": "GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5EB68-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EB76-1", "uniprot_id": [ { "id": "VA0E2_RAT", "url": "https://www.uniprot.org/uniprot/Q5EB76", "type": "external" } ], "mass": 9198.0, "length": 81, "protein_name": "V-type proton ATPase subunit e 2", "gene_name": "Atp6v0e2", "organism": "Rat", "refseq_name": "V-type proton ATPase subunit e 2", "refseq_ac": [ { "id": "NP_001002253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002253", "type": "external" } ], "gene_names_uniprotkb": "Atp6v0e2", "gene_names_refseq": "Atp6v0e2; NM9.2", "protein_names_uniprotkb": "V-type proton ATPase subunit e 2; V-ATPase subunit e 2; Vacuolar proton pump subunit e 2", "protein_names_refseq": "ATPase, H+ transporting, V0 subunit E; ATPase, H+ transporting, lysosomal V0 subunit E2; V-ATPase subunit e 2; V-type proton ATPase subunit e 2; vacuolar proton pump subunit e 2", "tax_id": 10116, "disease": "", "pathway": " (rno:436582); (R-RNO-1222556); (R-RNO-77387); (R-RNO-917977); (R-RNO-9639288); (R-RNO-983712)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "12544825;24090084;32165585", "class_list": "", "function": "A cDNA encoding a novel putative neuron-specific isoform of vacuolar proton-translocating ATPase (V-ATPase), NM9.2, was isolated from rat and mouse., [RefSeq, PubMed]; Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32165585). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32165585)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0030665 clathrin-coated vesicle membrane;GO:0030672 synaptic vesicle membrane;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain", "go_biological_process": "GO:0097401 synaptic vesicle lumen acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5EB76-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EB96-1", "uniprot_id": [ { "id": "SEPT1_RAT", "url": "https://www.uniprot.org/uniprot/Q5EB96", "type": "external" } ], "mass": 42058.0, "length": 366, "protein_name": "Septin-1", "gene_name": "Septin1", "organism": "Rat", "refseq_name": "septin-1", "refseq_ac": [ { "id": "NP_001012478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012478", "type": "external" } ], "gene_names_uniprotkb": "Septin1; Sept1", "gene_names_refseq": "Sept1; Septin1", "protein_names_uniprotkb": "Septin-1", "protein_names_refseq": "septin-1", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:293507)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)., [UniProtKB]; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005940 septin ring;GO:0005813 centrosome;GO:0015630 microtubule cytoskeleton;GO:0030496 midbody;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis;GO:0017157 regulation of exocytosis;GO:0007056 spindle assembly involved in female meiosis;GO:0051311 meiotic metaphase chromosome alignment", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5EB96-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EB97-1", "uniprot_id": [ { "id": "ZCH10_RAT", "url": "https://www.uniprot.org/uniprot/Q5EB97", "type": "external" } ], "mass": 18715.0, "length": 173, "protein_name": "Zinc finger CCHC domain-containing protein 10", "gene_name": "AABR07072108.1; Zcchc10", "organism": "Rat", "refseq_name": "zinc finger CCHC domain-containing protein 10", "refseq_ac": [ { "id": "NP_001257955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257955", "type": "external" } ], "gene_names_uniprotkb": "AABR07072108.1; Zcchc10; Zcchc10", "gene_names_refseq": "Zcchc10", "protein_names_uniprotkb": "Zinc finger CCHC domain-containing protein 10", "protein_names_refseq": "zinc finger CCHC domain-containing protein 10; zinc finger, CCHC domain containing 10", "tax_id": 10116, "disease": "", "pathway": " (rno:360524)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5EB97-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVG1-1", "uniprot_id": [ { "id": "GP157_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVG1", "type": "external" } ], "mass": 36687.0, "length": 330, "protein_name": "G protein-coupled receptor 157", "gene_name": "Gpr157", "organism": "Rat", "refseq_name": "G-protein coupled receptor 157", "refseq_ac": [ { "id": "NP_001012107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012107", "type": "external" } ], "gene_names_uniprotkb": "Gpr157", "gene_names_refseq": "Gpr157", "protein_names_uniprotkb": "G protein-coupled receptor 157", "protein_names_refseq": "G-protein coupled receptor 157; probable G-protein coupled receptor 157", "tax_id": 10116, "disease": "", "pathway": " (rno:313725)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0060170 ciliary membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0048512 circadian behavior;GO:0060019 radial glial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVG1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVJ8-1", "uniprot_id": [ { "id": "SENP8_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVJ8", "type": "external" } ], "mass": 24728.0, "length": 217, "protein_name": "Sentrin-specific protease 8", "gene_name": "Senp8", "organism": "Rat", "refseq_name": "sentrin-specific protease 8", "refseq_ac": [ { "id": "NP_001012355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012355", "type": "external" } ], "gene_names_uniprotkb": "Senp8", "gene_names_refseq": "Senp8", "protein_names_uniprotkb": "Sentrin-specific protease 8; 3.4.22.-; Deneddylase-1; NEDD8-specific protease 1; Sentrin/SUMO-specific protease SENP8", "protein_names_refseq": "NEDD8-specific protease 1; SUMO/sentrin peptidase family member, NEDD8 specific; SUMO/sentrin specific peptidase 8; SUMO/sentrin specific peptidase family member 8; SUMO/sentrin specific protease family member 8; Sumo1/sentrin/SMT3 specific peptidase 8; deneddylase-1; sentrin-specific protease 8; sentrin/SUMO-specific protease SENP8", "tax_id": 10116, "disease": "", "pathway": " (rno:315723); (R-RNO-5689603); (R-RNO-8951664)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "36847487", "class_list": "", "function": "Deneddylating enzyme SENP8 regulates neuronal development., [RefSeq, PubMed]; Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0019784 deNEDDylase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0000338 protein deneddylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FVJ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVL0-1", "uniprot_id": [ { "id": "VA0D2_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVL0", "type": "external" } ], "mass": 40520.0, "length": 350, "protein_name": "V-type proton ATPase subunit d 2", "gene_name": "Atp6v0d2", "organism": "Rat", "refseq_name": "V-type proton ATPase subunit d 2", "refseq_ac": [ { "id": "NP_001011972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011972", "type": "external" } ], "gene_names_uniprotkb": "Atp6v0d2", "gene_names_refseq": "Atp6v0d2", "protein_names_uniprotkb": "V-type proton ATPase subunit d 2; V-ATPase subunit d 2; Vacuolar proton pump subunit d 2", "protein_names_refseq": "ATPase, H+ transporting, V0 subunit D; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2; ATPase, H+ transporting, lysosomal V0 subunit D2; V-ATPase subunit d 2; V-type proton ATPase subunit d 2; vacuolar proton pump subunit d 2", "tax_id": 10116, "disease": "", "pathway": " (rno:297932); (R-RNO-1222556); (R-RNO-77387); (R-RNO-917977); (R-RNO-9639288); (R-RNO-983712)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "16192400", "class_list": "", "function": "Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). Regulator of osteoclast fusion and bone formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex", "go_biological_process": "GO:0007034 vacuolar transport;GO:0007035 vacuolar acidification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FVL0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVN0-1", "uniprot_id": [ { "id": "MBOA5_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVN0", "type": "external" } ], "mass": 56018.0, "length": 487, "protein_name": "Lysophospholipid acyltransferase 5", "gene_name": "Lpcat3", "organism": "Rat", "refseq_name": "lysophospholipid acyltransferase 5", "refseq_ac": [ { "id": "NP_001012189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012189", "type": "external" } ], "gene_names_uniprotkb": "Lpcat3; Grcc3f; Mboat5; Oact5", "gene_names_refseq": "Grcc3f; Lpcat3; Mboat5; Oact5", "protein_names_uniprotkb": "Lysophospholipid acyltransferase 5; 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase; 1-acylglycerophosphoserine O-acyltransferase; 2.3.1.-; 2.3.1.23; 2.3.1.n6; 2.3.1.n7; LPLAT 5; Lyso-PC acyltransferase 3; Lysophosphatidylcholine acyltransferase 3; Membrane-bound O-acyltransferase domain-containing protein 5; O-acyltransferase domain-containing protein 5", "protein_names_refseq": "1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase; 1-acylglycerophosphoserine O-acyltransferase; LPLAT 5; O-acyltransferase (membrane bound) domain containing 5; O-acyltransferase domain-containing protein 5; gene rich cluster, C3f; lyso-PC acyltransferase 3; lysophospholipid acyltransferase 5; membrane bound O-acyltransferase domain containing 5; membrane-bound O-acyltransferase domain-containing protein 5", "tax_id": 10116, "disease": "", "pathway": " (rno:362434); (R-RNO-1482788); (R-RNO-1482801); (R-RNO-1482839)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "15322104;38484924", "class_list": "", "function": "LPCAT3 exacerbates early brain injury and ferroptosis after subarachnoid hemorrhage in rats., [RefSeq, PubMed]; Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle. Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs (By similarity). Has higher activity for LPC acyl acceptors compared to LPEs and LPSs. Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency. Acts as a major LPC O-acyltransferase in liver and intestine. As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus. Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation. Down-regulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins. In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly. In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; PTG has a role in phosphorylase kinase inactivation and glycogen synthase translocation, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" } ], "go_molecular_function": "GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0071617 lysophospholipid acyltransferase activity;GO:0106262 1-acylglycerophosphoethanolamine O-acyltransferase activity;GO:0106263 1-acylglycerophosphoserine O-acyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0097006 regulation of plasma lipoprotein particle levels;GO:0090158 endoplasmic reticulum membrane organization;GO:0045540 regulation of cholesterol biosynthetic process;GO:0050728 negative regulation of inflammatory response;GO:0006656 phosphatidylcholine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5FVN0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVP2-1", "uniprot_id": [ { "id": "SOSB2_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVP2", "type": "external" } ], "mass": 21855.0, "length": 198, "protein_name": "SOSS complex subunit B2", "gene_name": "Nabp1", "organism": "Rat", "refseq_name": "SOSS complex subunit B2", "refseq_ac": [ { "id": "NP_001014238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014238", "type": "external" } ], "gene_names_uniprotkb": "Nabp1; Obfc2a; Ssb2", "gene_names_refseq": "Nabp1; Obfc2a; RGD1306658", "protein_names_uniprotkb": "SOSS complex subunit B2; Nucleic acid-binding protein 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; SOSS-B2; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; Single-stranded DNA-binding protein 2", "protein_names_refseq": "SOSS complex subunit B2; SOSS-B2; oligonucleotide/oligosaccharide-binding fold containing 2A; oligonucleotide/oligosaccharide-binding fold-containing protein 2A; sensor of single-strand DNA complex subunit B2; sensor of ssDNA subunit B2; single-stranded DNA-binding protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:363227); (R-RNO-6807505)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0035861 site of double-strand break;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0010212 response to ionizing radiation;GO:0000724 double-strand break repair via homologous recombination;GO:0044818 mitotic G2/M transition checkpoint", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVP2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVQ0-1", "uniprot_id": [ { "id": "S39A8_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVQ0", "type": "external" } ], "mass": 50171.0, "length": 462, "protein_name": "Metal cation symporter ZIP8", "gene_name": "Slc39a8", "organism": "Rat", "refseq_name": "metal cation symporter ZIP8 precursor", "refseq_ac": [ { "id": "NP_001011952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011952", "type": "external" } ], "gene_names_uniprotkb": "Slc39a8; Zip8", "gene_names_refseq": "Slc39a8", "protein_names_uniprotkb": "Metal cation symporter ZIP8; Solute carrier family 39 member 8; ZIP-8; Zrt- and Irt-like protein 8", "protein_names_refseq": "ZIP-8; metal cation symporter ZIP8 precursor; metal cation symporter ZIP8; solute carrier family 39 (metal ion transporter), member 8; solute carrier family 39 (zinc transporter), member 8; zinc transporter ZIP8; zrt- and Irt-like protein 8", "tax_id": 10116, "disease": "idiopathic scoliosis (Disease Ontology:DOID:0060250); left ventricular noncompaction (Disease Ontology:DOID:0060480); congenital disorder of glycosylation type IIn (Disease Ontology:DOID:0070266)", "pathway": " (rno:295455); (R-RNO-442380)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22898811;33677133", "class_list": "", "function": "Electroneutral divalent metal cation:bicarbonate symporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis and immunity (PubMed:22898811). Transports an electroneutral complex composed of a divalent metal cation and two bicarbonate anions or alternatively a bicarbonate and a selenite anion (PubMed:22898811). Thereby, it also contributes to the cellular uptake of selenium, an essential trace metal and micronutrient (PubMed:22898811). Also imports cadmium a non-essential metal which is cytotoxic and carcinogenic (PubMed:22898811). May also transport iron and cobalt through membranes (PubMed:22898811). Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development. Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization. Indirectly controls innate immune function and inflammatory response by regulating zinc cellular uptake which in turn modulates the expression of genes specific of these processes. Protects, for instance, cells from injury and death at the onset of inflammation (By similarity). By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries (By similarity). Reclaims manganese from the bile at the apical membrane of hepatocytes, thereby regulating the activity of the manganese-dependent enzymes through the systemic levels of the nutrient. Also participates in manganese reabsorption in the proximal tubule of the kidney. By mediating the extracellular uptake of manganese by cells of the blood-brain barrier, may also play a role in the transport of the micronutrient to the brain. With manganese cellular uptake also participates in mitochondrial proper function (By similarity). Finally, also probably functions intracellularly, translocating zinc from lysosome to cytosol to indirectly enhance the expression of specific genes during TCR-mediated T cell activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; ZIP8 mediates the extracellular matrix degradation of nucleus pulposus cells via NF-kappaB signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0140412 zinc:bicarbonate symporter activity;GO:0140410 monoatomic cation:bicarbonate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane;GO:0031090 organelle membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0006351 DNA-templated transcription;GO:0030198 extracellular matrix organization;GO:0042391 regulation of membrane potential", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5FVQ0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FWU5-1", "uniprot_id": [ { "id": "ZN513_RAT", "url": "https://www.uniprot.org/uniprot/Q5FWU5", "type": "external" } ], "mass": 58091.0, "length": 541, "protein_name": "Zinc finger protein 513", "gene_name": "Znf513", "organism": "Rat", "refseq_name": "zinc finger protein 513", "refseq_ac": [ { "id": "NP_001012110", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012110", "type": "external" } ], "gene_names_uniprotkb": "Znf513; Zfp513", "gene_names_refseq": "Zfp513; Znf513", "protein_names_uniprotkb": "Zinc finger protein 513", "protein_names_refseq": "zinc finger protein 513", "tax_id": 10116, "disease": "retinitis pigmentosa 58 (Disease Ontology:DOID:0110362)", "pathway": " (rno:313913)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Transcriptional regulator that plays a role in retinal development and maintenance., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FWU5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5HZA3-1", "uniprot_id": [ { "id": "ZCH12_RAT", "url": "https://www.uniprot.org/uniprot/Q5HZA3", "type": "external" } ], "mass": 45154.0, "length": 401, "protein_name": "Zinc finger CCHC domain-containing protein 12", "gene_name": "Zcchc12", "organism": "Rat", "refseq_name": "zinc finger CCHC domain-containing protein 12", "refseq_ac": [ { "id": "NP_001014087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014087", "type": "external" } ], "gene_names_uniprotkb": "Zcchc12", "gene_names_refseq": "Zcchc12", "protein_names_uniprotkb": "Zinc finger CCHC domain-containing protein 12", "protein_names_refseq": "zinc finger CCHC domain-containing protein 12; zinc finger, CCHC domain containing 12", "tax_id": 10116, "disease": "", "pathway": " (rno:313436)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0032183 SUMO binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0016605 PML body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030509 BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5HZA3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0E8-1", "uniprot_id": [ { "id": "KIF22_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0E8", "type": "external" } ], "mass": 73056.0, "length": 657, "protein_name": "Kinesin-like protein KIF22", "gene_name": "Kif22", "organism": "Rat", "refseq_name": "kinesin-like protein KIF22", "refseq_ac": [ { "id": "NP_001009645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009645", "type": "external" } ], "gene_names_uniprotkb": "Kif22", "gene_names_refseq": "Kif22", "protein_names_uniprotkb": "Kinesin-like protein KIF22", "protein_names_refseq": "kinesin-like protein KIF22-like; kinesin-like protein KIF22", "tax_id": 10116, "disease": "spondyloepimetaphyseal dysplasia with joint laxity type 2 (Disease Ontology:DOID:0112199)", "pathway": " (rno:293502); (R-RNO-2132295); (R-RNO-6811434); (R-RNO-983189)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005874 microtubule;GO:0016607 nuclear speck;GO:0005871 kinesin complex", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0006281 DNA repair;GO:0007018 microtubule-based movement;GO:0007080 mitotic metaphase chromosome alignment;GO:0007062 sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0E8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0J4-1", "uniprot_id": [ { "id": "SKA2_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0J4", "type": "external" } ], "mass": 16517.0, "length": 144, "protein_name": "SKA complex subunit 2", "gene_name": "Ska2", "organism": "Rat", "refseq_name": "SKA complex subunit 2", "refseq_ac": [ { "id": "NP_001009624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009624", "type": "external" } ], "gene_names_uniprotkb": "Ska2; Fam33a", "gene_names_refseq": "Fam33a; RGD1307084; Ska2", "protein_names_uniprotkb": "SKA complex subunit 2; Protein FAM33A; Spindle and kinetochore-associated protein 2", "protein_names_refseq": "SKA complex subunit 2; family with sequence similarity 33, member A; spindle and kinetochore-associated protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:287598); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle. The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules together with MAPRE1, and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces. The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules. The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase. Binds directly to microtubules; but with a much lower affinity than SKA1 (By similarity). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6HHS9", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0000776 kinetochore;GO:0005876 spindle microtubule;GO:0072687 meiotic spindle;GO:0000940 outer kinetochore", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0J4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5J3E5-1", "uniprot_id": [ { "id": "V1R98_RAT", "url": "https://www.uniprot.org/uniprot/Q5J3E5", "type": "external" } ], "mass": 35893.0, "length": 314, "protein_name": "Vomeronasal type-1 receptor 98", "gene_name": "Vom1r98", "organism": "Rat", "refseq_name": "vomeronasal type-1 receptor 98", "refseq_ac": [ { "id": "NP_001008948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008948", "type": "external" } ], "gene_names_uniprotkb": "Vom1r98; V1ra8", "gene_names_refseq": "V1ra8; Vom1r98", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 98; Vomeronasal type-1 receptor A8", "protein_names_refseq": "vomernasal 1 receptor Vom1r98; vomeronasal 1 receptor, A8; vomeronasal V1r-type receptor V1ra8; vomeronasal type-1 receptor 98; vomeronasal type-1 receptor A8", "tax_id": 10116, "disease": "", "pathway": " (rno:494294)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5J3E5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5J3F6-1", "uniprot_id": [ { "id": "V1R90_RAT", "url": "https://www.uniprot.org/uniprot/Q5J3F6", "type": "external" } ], "mass": 35324.0, "length": 310, "protein_name": "Vomeronasal type-1 receptor 90", "gene_name": "Vom1r90", "organism": "Rat", "refseq_name": "vomeronasal type-1 receptor 90", "refseq_ac": [ { "id": "NP_714951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_714951", "type": "external" } ], "gene_names_uniprotkb": "Vom1r90; V1ra16", "gene_names_refseq": "V1ra16; Vom1r90", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 90; Pheromone receptor VN6; Vomeronasal receptor 6; Vomeronasal type-1 receptor A16", "protein_names_refseq": "pheromone receptor VN6; putative pheromone receptor VN6; vomernasal 1 receptor Vom1r90; vomeronasal 1 receptor, A16; vomeronasal V1r-type receptor V1ra16; vomeronasal receptor 6; vomeronasal type-1 receptor 90; vomeronasal type-1 receptor A16", "tax_id": 10116, "disease": "", "pathway": " (rno:266771)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7585937", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62855", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5J3F6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5J3G9-1", "uniprot_id": [ { "id": "V1R95_RAT", "url": "https://www.uniprot.org/uniprot/Q5J3G9", "type": "external" } ], "mass": 35674.0, "length": 314, "protein_name": "Vomeronasal type-1 receptor 95", "gene_name": "Vom1r95", "organism": "Rat", "refseq_name": "vomeronasal type-1 receptor 95", "refseq_ac": [ { "id": "NP_001406647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001406647", "type": "external" } ], "gene_names_uniprotkb": "Vom1r95; 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Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May also be involved in the biogenesis of lysosome-related organelles such as melanosomes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0099078 BORC complex;GO:0031083 BLOC-1 complex", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0032418 lysosome localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M853-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M934-1", "uniprot_id": [ { "id": "TRUB1_RAT", "url": "https://www.uniprot.org/uniprot/Q5M934", "type": "external" } ], "mass": 36404.0, "length": 341, "protein_name": "Pseudouridylate synthase TRUB1", "gene_name": "Trub1", "organism": "Rat", "refseq_name": "pseudouridylate synthase TRUB1", "refseq_ac": [ { "id": "NP_001012173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012173", "type": "external" } ], "gene_names_uniprotkb": "Trub1", "gene_names_refseq": "Trub1", "protein_names_uniprotkb": "Pseudouridylate synthase TRUB1; 5.4.99.-; 5.4.99.25; Psi55 synthase TRUB1; TruB pseudouridine synthase homolog 1; tRNA pseudouridine 55 synthase TRUB1", "protein_names_refseq": "TruB pseudouridine (psi) synthase family member 1; TruB pseudouridine (psi) synthase homolog 1; probable tRNA pseudouridine synthase 1; pseudouridylate synthase TRUB1; psi55 synthase TRUB1; tRNA pseudouridine 55 synthase TRUB1; truB pseudouridine synthase homolog 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361775)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs. Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure. Constitutes the major pseudouridine synthase acting on mRNAs. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs. Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity. Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.4.99.25", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.25", "type": "external" }, { "id": "5.4.99.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.12", "type": "external" }, { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" } ], "go_molecular_function": "GO:0009982 pseudouridine synthase activity;GO:0070883 pre-miRNA binding;GO:0160148 tRNA pseudouridine(55) synthase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0031119 tRNA pseudouridine synthesis;GO:0006397 mRNA processing;GO:0006400 tRNA modification;GO:1990481 mRNA pseudouridine synthesis;GO:2000633 positive regulation of pre-miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M934-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M954-1", "uniprot_id": [ { "id": "SEN2_RAT", "url": "https://www.uniprot.org/uniprot/Q5M954", "type": "external" } ], "mass": 52952.0, "length": 463, "protein_name": "tRNA-splicing endonuclease subunit Sen2", "gene_name": "Tsen2", "organism": "Rat", "refseq_name": "tRNA-splicing endonuclease subunit Sen2", "refseq_ac": [ { "id": "NP_001014079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014079", "type": "external" } ], "gene_names_uniprotkb": "Tsen2", "gene_names_refseq": "RGD1309946; Tsen2", "protein_names_uniprotkb": "tRNA-splicing endonuclease subunit Sen2; 4.6.1.16; tRNA-intron endonuclease Sen2", "protein_names_refseq": "TSEN2 tRNA splicing endonuclease subunit; tRNA-intron endonuclease Sen2; tRNA-intron nuclease 2; tRNA-splicing endonuclease subunit Sen2", "tax_id": 10116, "disease": "pontocerebellar hypoplasia type 2B (Disease Ontology:DOID:0060268)", "pathway": " (rno:312649)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0000213 tRNA-intron lyase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000214 tRNA-intron endonuclease complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008033 tRNA processing;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0000379 tRNA-type intron splice site recognition and cleavage", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M954-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M9F8-1", "uniprot_id": [ { "id": "SCYL1_RAT", "url": "https://www.uniprot.org/uniprot/Q5M9F8", "type": "external" } ], "mass": 89126.0, "length": 807, "protein_name": "N-terminal kinase-like protein", "gene_name": "Scyl1", "organism": "Rat", "refseq_name": "N-terminal kinase-like protein", "refseq_ac": [ { "id": "NP_001011938", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011938", "type": "external" } ], "gene_names_uniprotkb": "Scyl1", "gene_names_refseq": "Scyl1", "protein_names_uniprotkb": "N-terminal kinase-like protein; SCY1-like protein 1", "protein_names_refseq": "N-terminal kinase-like protein; SCY1-like protein 1; SCY1-like, kinase-like 1", "tax_id": 10116, "disease": "hereditary ataxia (Disease Ontology:DOID:0050951); autosomal recessive spinocerebellar ataxia 21 (Disease Ontology:DOID:0111155)", "pathway": " (rno:293684)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18556652", "class_list": "", "function": "Data demonstrate a function for Scyl1 as an accessory factor in COPI trafficking and suggest that alterations in the COPI pathway result in neurodegenerative disease., [RefSeq, PubMed]; Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0006954 inflammatory response;GO:0021522 spinal cord motor neuron differentiation;GO:0008104 intracellular protein localization;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M9F8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M9G1-1", "uniprot_id": [ { "id": "HEXI1_RAT", "url": "https://www.uniprot.org/uniprot/Q5M9G1", "type": "external" } ], "mass": 40317.0, "length": 356, "protein_name": "Protein HEXIM1", "gene_name": "Hexim1", "organism": "Rat", "refseq_name": "protein HEXIM1", "refseq_ac": [ { "id": "NP_001020307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020307", "type": "external" } ], "gene_names_uniprotkb": "Hexim1; Clp1", "gene_names_refseq": "Clp-1; Clp1; Hexim1", "protein_names_uniprotkb": "Protein HEXIM1; Cardiac lineage protein 1", "protein_names_refseq": "cardiac lineage protein 1; hexamethylene bis-acetamide inducible 1; protein HEXIM1", "tax_id": 10116, "disease": "", "pathway": " (rno:498008)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12119119;22673903;29393594", "class_list": "", "function": "Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004860 protein kinase inhibitor activity;GO:0017069 snRNA binding;GO:0097322 7SK snRNA binding;GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0120259 7SK snRNP", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5M9G1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPF5-1", "uniprot_id": [ { "id": "ZGPAT_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPF5", "type": "external" } ], "mass": 56172.0, "length": 507, "protein_name": "Zinc finger CCCH-type with G patch domain-containing protein", "gene_name": "Zgpat", "organism": "Rat", "refseq_name": "zinc finger CCCH-type with G patch domain-containing protein", "refseq_ac": [ { "id": "NP_001009656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009656", "type": "external" } ], "gene_names_uniprotkb": "Zgpat", "gene_names_refseq": "RGD1310801; Zgpat", "protein_names_uniprotkb": "Zinc finger CCCH-type with G patch domain-containing protein", "protein_names_refseq": "zinc finger CCCH-type with G patch domain-containing protein; zinc finger, CCCH-type with G patch domain", "tax_id": 10116, "disease": "", "pathway": " (rno:296478)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0007175 negative regulation of epidermal growth factor-activated receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PPF5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPI9-1", "uniprot_id": [ { "id": "TTLL1_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPI9", "type": "external" } ], "mass": 49140.0, "length": 423, "protein_name": "Polyglutamylase complex subunit TTLL1", "gene_name": "Ttll1", "organism": "Rat", "refseq_name": "polyglutamylase complex subunit TTLL1", "refseq_ac": [ { "id": "NP_001012200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012200", "type": "external" } ], "gene_names_uniprotkb": "Ttll1", "gene_names_refseq": "PGs3; Ttll1", "protein_names_uniprotkb": "Polyglutamylase complex subunit TTLL1; 6.3.2.-; PGs3; Tubulin polyglutamylase TTLL1; Tubulin polyglutamylase complex subunit 3; Tubulin--tyrosine ligase-like protein 1", "protein_names_refseq": "polyglutamylase complex subunit TTLL1; probable tubulin polyglutamylase TTLL1; tubulin polyglutamylase complex subunit 3; tubulin tyrosine ligase like 1; tubulin tyrosine ligase-like family, member 1; tubulin--tyrosine ligase-like protein 1", "tax_id": 10116, "disease": "primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (rno:362969)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic subunit of a polyglutamylase complex which modifies tubulin, generating side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Probably involved in the side-chain elongation step of the polyglutamylation reaction rather than the initiation step. Modifies both alpha- and beta-tubulins with a preference for the alpha-tail. Unlike most polyglutamylases of the tubulin--tyrosine ligase family, only displays a catalytic activity when in complex with other proteins as it is most likely lacking domains important for autonomous activity. Part of the neuronal tubulin polyglutamylase complex. Mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility. Involved in respiratory motile cilia function through the regulation of beating asymmetry. Essential for sperm flagella biogenesis, motility and male fertility. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0070740 tubulin-glutamic acid ligase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0015631 tubulin binding;GO:0106438 protein-glutamic acid ligase activity, elongating", "go_cellular_component": "GO:0005576 extracellular region;GO:0005874 microtubule;GO:0031514 motile cilium;GO:0005930 axoneme;GO:0036064 ciliary basal body", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:0000226 microtubule cytoskeleton organization;GO:0021702 cerebellar Purkinje cell differentiation;GO:0002395 immune response in nasopharyngeal-associated lymphoid tissue", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PPI9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPP3-1", "uniprot_id": [ { "id": "TCAL1_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPP3", "type": "external" } ], "mass": 19262.0, "length": 165, "protein_name": "Transcription elongation factor A protein-like 1", "gene_name": "Tceal1", "organism": "Rat", "refseq_name": "transcription elongation factor A protein-like 1", "refseq_ac": [ { "id": "NP_001009675", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009675", "type": "external" } ], "gene_names_uniprotkb": "Tceal1", "gene_names_refseq": "Tceal1", "protein_names_uniprotkb": "Transcription elongation factor A protein-like 1; TCEA-like protein 1; Transcription elongation factor S-II protein-like 1", "protein_names_refseq": "TCEA-like protein 1; transcription elongation factor A (SII)-like 1; transcription elongation factor A protein-like 1; transcription elongation factor S-II protein-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:302593)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. Does not bind DNA directly (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PPP3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQK8-1", "uniprot_id": [ { "id": "TBRG1_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQK8", "type": "external" } ], "mass": 44785.0, "length": 406, "protein_name": "Transforming growth factor beta regulator 1", "gene_name": "Tbrg1", "organism": "Rat", "refseq_name": "transforming growth factor beta regulator 1", "refseq_ac": [ { "id": "NP_001009344", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009344", "type": "external" } ], "gene_names_uniprotkb": "Tbrg1", "gene_names_refseq": "Tbrg1", "protein_names_uniprotkb": "Transforming growth factor beta regulator 1", "protein_names_refseq": "transforming growth factor beta regulated gene 1; transforming growth factor beta regulator 1", "tax_id": 10116, "disease": "", "pathway": " (rno:300521)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:1990173 protein localization to nucleoplasm;GO:0008285 negative regulation of cell population proliferation;GO:0006260 DNA replication;GO:0050821 protein stabilization;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PQK8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQM9-1", "uniprot_id": [ { "id": "KMCP1_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQM9", "type": "external" } ], "mass": 32365.0, "length": 291, "protein_name": "Kidney mitochondrial carrier protein 1", "gene_name": "Slc25a30", "organism": "Rat", "refseq_name": "kidney mitochondrial carrier protein 1", "refseq_ac": [ { "id": "NP_001013205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013205", "type": "external" } ], "gene_names_uniprotkb": "Slc25a30; Kmcp1", "gene_names_refseq": "Slc25a30", "protein_names_uniprotkb": "Kidney mitochondrial carrier protein 1; Solute carrier family 25 member 30", "protein_names_refseq": "kidney mitochondrial carrier protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361074)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Antiporter that transports inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate. The sulfate/sulfate exchange is much higher than the phosphate/phosphate and malate/malate exchanges. The transport affinities is higher for sulfate and thiosulfate than for any other substrate. May catalyze the export of sulfite and thiosulfate (the hydrogen sulfide degradation products) from the mitochondria, thereby modulating the level of the hydrogen sulfide. Also may mediate a very low unidirectional transport of sulfate, phosphate and (S)-malate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0005452 solute:inorganic anion antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015698 inorganic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQM9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQP5-1", "uniprot_id": [ { "id": "SLX1_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQP5", "type": "external" } ], "mass": 30746.0, "length": 271, "protein_name": "Structure-specific endonuclease subunit SLX1", "gene_name": "Slx1b", "organism": "Rat", "refseq_name": "structure-specific endonuclease subunit SLX1", "refseq_ac": [ { "id": "NP_001009292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009292", "type": "external" } ], "gene_names_uniprotkb": "Slx1b; Giyd1; Giyd2; Slx1", "gene_names_refseq": "Giyd1; Giyd2; LRRGT00058; RGD1311568; Slx1b", "protein_names_uniprotkb": "Structure-specific endonuclease subunit SLX1; 3.1.-.-; GIY-YIG domain-containing protein 1", "protein_names_refseq": "GIY-YIG domain containing 2; GIY-YIG domain-containing protein 1; structure-specific endonuclease subunit SLX1", "tax_id": 10116, "disease": "Fanconi-like syndrome (Disease Ontology:DOID:0090066)", "pathway": " (rno:293489); (R-RNO-5693568); (R-RNO-6783310)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008821 crossover junction DNA endonuclease activity;GO:0017108 5'-flap endonuclease activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000228 nuclear chromosome;GO:0033557 Slx1-Slx4 complex", "go_biological_process": "GO:1904431 positive regulation of t-circle formation;GO:0010833 telomere maintenance via telomere lengthening;GO:0006281 DNA repair;GO:0000724 double-strand break repair via homologous recombination;GO:0061820 telomeric D-loop disassembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQP5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQS6-1", "uniprot_id": [ { "id": "SMG9_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQS6", "type": "external" } ], "mass": 57633.0, "length": 520, "protein_name": "Nonsense-mediated mRNA decay factor SMG9", "gene_name": "Smg9", "organism": "Rat", "refseq_name": "nonsense-mediated mRNA decay factor SMG9", "refseq_ac": [ { "id": "NP_001014265", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014265", "type": "external" } ], "gene_names_uniprotkb": "Smg9", "gene_names_refseq": "RGD1309888; Smg9", "protein_names_uniprotkb": "Nonsense-mediated mRNA decay factor SMG9", "protein_names_refseq": "nonsense-mediated mRNA decay factor SMG9; protein SMG9; protein smg-9 homolog", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:365215); (R-RNO-975957)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (By similarity). Plays a role in brain, heart, and eye development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007507 heart development;GO:0043066 negative regulation of apoptotic process;GO:0007420 brain development;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5PQS6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJL6-1", "uniprot_id": [ { "id": "METRL_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJL6", "type": "external" } ], "mass": 34468.0, "length": 311, "protein_name": "Meteorin-like protein", "gene_name": "Metrnl", "organism": "Rat", "refseq_name": "meteorin-like protein precursor", "refseq_ac": [ { "id": "NP_001014126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014126", "type": "external" } ], "gene_names_uniprotkb": "Metrnl", "gene_names_refseq": "Metrnl", "protein_names_uniprotkb": "Meteorin-like protein; Subfatin", "protein_names_refseq": "meteorin, glial cell differentiation regulator-like; meteorin-like protein precursor; meteorin-like protein; subfatin", "tax_id": 10116, "disease": "", "pathway": " (rno:316842)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22344266;24393292;32594095;32812347;36334887", "class_list": "", "function": "Effects of electrical stimulation-induced resistance exercise training on white and brown adipose tissues and plasma meteorin-like concentration in rats., [RefSeq, PubMed]; Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity)., [UniProtKB]; Meteorin-Like (METRNL) Attenuates Myocardial Ischemia/Reperfusion Injury-Induced Cardiomyocytes Apoptosis by Alleviating Endoplasmic Reticulum Stress via Activation of AMPK-PAK2 Signaling in H9C2 Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy., [RefSeq, PubMed]; Metrnl, Dclk1 and Serpinb1a have been identified as genes that are induced during the latent process (LP) for cell differentiation with distinct temporal expression profiles and are required for subsequent neurite extension., [RefSeq, PubMed]; Results show that Subfatin is a novel adipokine regulated by adipogenesis and obesity, with tissue distribution different from its homologue Meteorin, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0009409 response to cold;GO:0050873 brown fat cell differentiation;GO:0050728 negative regulation of inflammatory response;GO:0097009 energy homeostasis;GO:0045444 fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5RJL6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJQ7-1", "uniprot_id": [ { "id": "SDHF2_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJQ7", "type": "external" } ], "mass": 19524.0, "length": 164, "protein_name": "Succinate dehydrogenase assembly factor 2, mitochondrial", "gene_name": "Sdhaf2", "organism": "Rat", "refseq_name": "succinate dehydrogenase assembly factor 2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001008372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008372", "type": "external" } ], "gene_names_uniprotkb": "Sdhaf2; PGL2; Pgl2; SDH5; SDHAF2; Sdh5", "gene_names_refseq": "RGD1309216; Sdhaf2", "protein_names_uniprotkb": "Succinate dehydrogenase assembly factor 2, mitochondrial; SDH assembly factor 2; SDHAF2", "protein_names_refseq": "SDH assembly factor 2; succinate dehydrogenase assembly factor 2, mitochondrial precursor; succinate dehydrogenase assembly factor 2, mitochondrial; succinate dehydrogenase subunit 5, mitochondrial", "tax_id": 10116, "disease": "pheochromocytoma/paraganglioma syndrome 2 (Disease Ontology:DOID:0061217)", "pathway": " (rno:361726); (R-RNO-9854311)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "29393594;36326104", "class_list": "", "function": "Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]; SDH5 down-regulation mitigates the damage of osteoporosis via inhibiting the MyD88/NF-kappaB signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006470 protein dephosphorylation;GO:0006121 mitochondrial electron transport, succinate to ubiquinone;GO:0010719 negative regulation of epithelial to mesenchymal transition", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5RJQ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJR4-1", "uniprot_id": [ { "id": "ZN467_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJR4", "type": "external" } ], "mass": 65753.0, "length": 594, "protein_name": "Zinc finger protein 467", "gene_name": "Znf467", "organism": "Rat", "refseq_name": "zinc finger protein 467", "refseq_ac": [ { "id": "NP_001019498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019498", "type": "external" } ], "gene_names_uniprotkb": "Znf467; Zfp467", "gene_names_refseq": "Zfp467; Znf467", "protein_names_uniprotkb": "Zinc finger protein 467", "protein_names_refseq": "zinc finger protein 467", "tax_id": 10116, "disease": "", "pathway": " (rno:500110)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RJR4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJZ6-1", "uniprot_id": [ { "id": "SCOC_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJZ6", "type": "external" } ], "mass": 13689.0, "length": 122, "protein_name": "Short coiled-coil protein", "gene_name": "Scoc", "organism": "Rat", "refseq_name": "short coiled-coil protein isoform 1", "refseq_ac": [ { "id": "NP_001013253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013253", "type": "external" } ], "gene_names_uniprotkb": "Scoc; Scoco", "gene_names_refseq": "Scoc", "protein_names_uniprotkb": "Short coiled-coil protein", "protein_names_refseq": "short coiled-coil protein A; short coiled-coil protein isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:364981); (R-RNO-6811440)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Positive regulator of amino acid starvation-induced autophagy., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0D2M9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0016239 positive regulation of macroautophagy;GO:0061635 regulation of protein complex stability", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RJZ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKJ1-1", "uniprot_id": [ { "id": "MAEA_RAT", "url": "https://www.uniprot.org/uniprot/Q5RKJ1", "type": "external" } ], "mass": 45336.0, "length": 396, "protein_name": "E3 ubiquitin-protein transferase MAEA", "gene_name": "Maea", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein transferase MAEA", "refseq_ac": [ { "id": "NP_001008320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008320", "type": "external" } ], "gene_names_uniprotkb": "Maea", "gene_names_refseq": "Maea", "protein_names_uniprotkb": "E3 ubiquitin-protein transferase MAEA; 2.3.2.27; Macrophage erythroblast attacher", "protein_names_refseq": "E3 ubiquitin-protein transferase MAEA", "tax_id": 10116, "disease": "", "pathway": " (rno:298982); (R-RNO-9861718)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.27", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005856 cytoskeleton", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0007155 cell adhesion;GO:0051301 cell division;GO:0007010 cytoskeleton organization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RKJ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U1W4-1", "uniprot_id": [ { "id": "LAP4B_RAT", "url": "https://www.uniprot.org/uniprot/Q5U1W4", "type": "external" } ], "mass": 25404.0, "length": 227, "protein_name": "Lysosomal-associated transmembrane protein 4B", "gene_name": "Laptm4b", "organism": "Rat", "refseq_name": "lysosomal-associated transmembrane protein 4B", "refseq_ac": [ { "id": "NP_001013192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013192", "type": "external" } ], "gene_names_uniprotkb": "Laptm4b", "gene_names_refseq": "Laptm4b", "protein_names_uniprotkb": "Lysosomal-associated transmembrane protein 4B", "protein_names_refseq": "lysosomal-associated protein transmembrane 4B; lysosomal-associated transmembrane protein 4B", "tax_id": 10116, "disease": "", "pathway": " (rno:315047)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32693673", "class_list": "", "function": "Downregulation of LAPTM4B Contributes to the Impairment of the Autophagic Flux via Unopposed Activation of mTORC1 Signaling During Myocardial Ischemia/Reperfusion Injury. Erratum:[Circ Res. 2023 Mar 3;132(5):e94. doi: 10.1161/RES.0000000000000597. PMID: 36862816], [RefSeq, PubMed]; Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0031625 ubiquitin protein ligase binding;GO:0019900 kinase binding;GO:0097001 ceramide binding", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0007032 endosome organization;GO:1905166 negative regulation of lysosomal protein catabolic process;GO:0032911 negative regulation of transforming growth factor beta1 production;GO:0032509 endosome transport via multivesicular body sorting pathway;GO:0097213 regulation of lysosomal membrane permeability", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U1W4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2S3-1", "uniprot_id": [ { "id": "ZUP1_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2S3", "type": "external" } ], "mass": 65722.0, "length": 577, "protein_name": "Zinc finger-containing ubiquitin peptidase 1", "gene_name": "Zup1", "organism": "Rat", "refseq_name": "zinc finger-containing ubiquitin peptidase 1", "refseq_ac": [ { "id": "NP_001008309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008309", "type": "external" } ], "gene_names_uniprotkb": "Zup1; Zufsp", "gene_names_refseq": "DUB; RGD1307672; Zufsp; Zup1", "protein_names_uniprotkb": "Zinc finger-containing ubiquitin peptidase 1; 3.4.19.12; DUB; Lys-63-specific deubiquitinase ZUFSP; Zinc finger with UFM1-specific peptidase domain protein", "protein_names_refseq": "lys-63-specific deubiquitinase ZUFSP; ubiquitin carboxyl-terminal hydrolase ZUFSP; zinc finger with UFM1-specific peptidase domain protein; zinc finger-containing ubiquitin peptidase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:294390)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2S3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2W5-1", "uniprot_id": [ { "id": "TBL3_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2W5", "type": "external" } ], "mass": 88372.0, "length": 800, "protein_name": "Transducin beta-like protein 3", "gene_name": "Tbl3", "organism": "Rat", "refseq_name": "transducin beta-like protein 3", "refseq_ac": [ { "id": "NP_001008278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008278", "type": "external" } ], "gene_names_uniprotkb": "Tbl3", "gene_names_refseq": "Tbl3", "protein_names_uniprotkb": "Transducin beta-like protein 3", "protein_names_refseq": "transducin beta-like protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:287120); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034511 U3 snoRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0030686 90S preribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2W5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2Y3-1", "uniprot_id": [ { "id": "MPP7_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2Y3", "type": "external" } ], "mass": 65623.0, "length": 576, "protein_name": "MAGUK p55 subfamily member 7", "gene_name": "Mpp7", "organism": "Rat", "refseq_name": "MAGUK p55 subfamily member 7", "refseq_ac": [ { "id": "NP_001094045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094045", "type": "external" } ], "gene_names_uniprotkb": "Mpp7", "gene_names_refseq": "Mpp7", "protein_names_uniprotkb": "MAGUK p55 subfamily member 7", "protein_names_refseq": "MAGUK p55 subfamily member 7; membrane palmitoylated protein 7; membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)", "tax_id": 10116, "disease": "", "pathway": " (rno:307035); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013406); (R-RNO-9013408); (R-RNO-9013423)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0005923 bicellular tight junction;GO:0005938 cell cortex", "go_biological_process": "GO:0031334 positive regulation of protein-containing complex assembly;GO:0070830 bicellular tight junction assembly;GO:0071896 protein localization to adherens junction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2Y3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2Z0-1", "uniprot_id": [ { "id": "ZN367_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2Z0", "type": "external" } ], "mass": 37472.0, "length": 340, "protein_name": "Zinc finger protein 367", "gene_name": "Znf367", "organism": "Rat", "refseq_name": "zinc finger protein 367", "refseq_ac": [ { "id": "NP_001012051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012051", "type": "external" } ], "gene_names_uniprotkb": "Znf367; Zfp367", "gene_names_refseq": "Zfp367; Znf367", "protein_names_uniprotkb": "Zinc finger protein 367", "protein_names_refseq": "zinc finger protein 367", "tax_id": 10116, "disease": "", "pathway": " (rno:306695)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional activator. May be involved in transcriptional activation of erythroid genes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2Z0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U3Y0-1", "uniprot_id": [ { "id": "KLD10_RAT", "url": "https://www.uniprot.org/uniprot/Q5U3Y0", "type": "external" } ], "mass": 45380.0, "length": 410, "protein_name": "Kelch domain-containing protein 10", "gene_name": "Klhdc10", "organism": "Rat", "refseq_name": "kelch domain-containing protein 10", "refseq_ac": [ { "id": "NP_001017456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017456", "type": "external" } ], "gene_names_uniprotkb": "Klhdc10", "gene_names_refseq": "Klhdc10; RGD1309792", "protein_names_uniprotkb": "Kelch domain-containing protein 10", "protein_names_refseq": "kelch domain-containing protein 10", "tax_id": 10116, "disease": "", "pathway": " (rno:312199); (R-RNO-9954709)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C-terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(KLHDC10) complex specifically recognizes proteins with a proline-glycine (Pro-Gly) or an alanine tail (CAT tail) at the C-terminus, leading to their ubiquitination and degradation (By similarity). The CRL2(KLHDC10) complex is involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: CRL2(KLHDC10) acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (By similarity). Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5 (By similarity). Acts as a regulator of necroptosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0016567 protein ubiquitination;GO:0032874 positive regulation of stress-activated MAPK cascade;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U3Y0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U3Y7-1", "uniprot_id": [ { "id": "SGMR2_RAT", "url": "https://www.uniprot.org/uniprot/Q5U3Y7", "type": "external" } ], "mass": 20946.0, "length": 176, "protein_name": "Sigma intracellular receptor 2", "gene_name": "Tmem97", "organism": "Rat", "refseq_name": "sigma intracellular receptor 2", "refseq_ac": [ { "id": "NP_001008335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008335", "type": "external" } ], "gene_names_uniprotkb": "Tmem97; S2r", "gene_names_refseq": "RGD1307423; Tmem97", "protein_names_uniprotkb": "Sigma intracellular receptor 2; Sigma-2 receptor; Sigma2 receptor; Transmembrane protein 97", "protein_names_refseq": "sigma intracellular receptor 2; sigma-2 receptor; sigma2 receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:303330)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sigma-2 receptor implicated in the regulation of multiple cellular processes, including cholesterol biosynthesis and trafficking, membrane trafficking, autophagy, lipid membrane-associated protein trafficking, and stabilization of receptors at the cell surface, thereby contributing to the maintenance of cellular homeostasis. Forms a ternary complex with PGRMC1 and LDLR at the plasma membrane, promoting LDLR-mediated internalization of LDL cholesterol. Reduces the availability of the lysosomal sterol transporter NPC1, likely through direct interaction, thereby regulating lipid transport, including cholesterol and LBPA, outside of late endosome/lysosome. Binds the regio- and stereoselective oxysterol 20(S)-hydroxycholesterol (20(S)-OHC). Ligand binding enhances association with NPC1 and modulates TMEM97-containing protein complexes involving PGRMC1 and TSPO, consistent with a role in cholesterol homeostasis (By similarity). Also able to bind cholesterol (By similarity). Interacts with the salivary peptide histatin 1 (Hst 1/HTN1) at the ER membrane, which is critical for increasing mitochondria-ER contacts and stimulating Hst 1 wound healing properties. May alter the activity of some cytochrome P450 proteins. Although sharing homology with sterol isomerases through the EXPERA domain, lacks sterol isomerase activity; instead, may function as a sterol or oxysterol sensor (By similarity). Acts as an ER quality control factor by promoting proteolytic degradation of nonproductive and extramitochondrial precursor proteins in the ER membrane, thereby removing them from the ER surface (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008142 oxysterol binding;GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005791 rough endoplasmic reticulum;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0005764 lysosome", "go_biological_process": "GO:0032383 regulation of intracellular cholesterol transport;GO:0042632 cholesterol homeostasis;GO:0090303 positive regulation of wound healing;GO:0140077 positive regulation of lipoprotein transport;GO:0032377 regulation of intracellular lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U3Y7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XFW8-1", "uniprot_id": [ { "id": "SEC13_RAT", "url": "https://www.uniprot.org/uniprot/Q5XFW8", "type": "external" } ], "mass": 35548.0, "length": 322, "protein_name": "Protein SEC13 homolog", "gene_name": "Sec13", "organism": "Rat", "refseq_name": "protein SEC13 homolog", "refseq_ac": [ { "id": "NP_001006979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006979", "type": "external" } ], "gene_names_uniprotkb": "Sec13; Sec13l1", "gene_names_refseq": "Sec13l1; Sec13", "protein_names_uniprotkb": "Protein SEC13 homolog; GATOR2 complex protein SEC13; SEC13-like protein 1", "protein_names_refseq": "GATOR complex protein SEC13; GATOR2 complex protein SEC13; SEC13 homolog, nuclear pore and COPII coat complex component; SEC13 homolog, nuclear pore and COPII coating complex component; SEC13-like protein 1; protein SEC13 homolog", "tax_id": 10116, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (rno:297522); (R-RNO-141430); (R-RNO-141444); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-170822); (R-RNO-1855170); (R-RNO-1855196); (R-RNO-1855229); (R-RNO-191859); (R-RNO-204005); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-3108214); (R-RNO-3232142); (R-RNO-3301854); (R-RNO-3371453); (R-RNO-4085377); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9615933); (R-RNO-9639288); (R-RNO-9648025); (R-RNO-983170)", "pathway_count": 29, "publication_count": 1, "publication_id_list": "10788476", "class_list": "", "function": "As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005765 lysosomal membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0090110 COPII-coated vesicle cargo loading;GO:0072659 protein localization to plasma membrane;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0031669 cellular response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XFW8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XHZ2-1", "uniprot_id": [ { "id": "SYCE1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XHZ2", "type": "external" } ], "mass": 38157.0, "length": 329, "protein_name": "Synaptonemal complex central element protein 1", "gene_name": "Syce1", "organism": "Rat", "refseq_name": "synaptonemal complex central element protein 1", "refseq_ac": [ { "id": "NP_001020229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020229", "type": "external" } ], "gene_names_uniprotkb": "Syce1", "gene_names_refseq": "Syce1", "protein_names_uniprotkb": "Synaptonemal complex central element protein 1", "protein_names_refseq": "synaptonemal complex central element protein 1; telomeric protein", "tax_id": 10116, "disease": "spermatogenic failure 15 (Disease Ontology:DOID:0070172); primary ovarian insufficiency 12 (Disease Ontology:DOID:0080869)", "pathway": " (rno:502372)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000801 central element;GO:0005694 chromosome;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0051301 cell division;GO:0007130 synaptonemal complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XHZ2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI50-1", "uniprot_id": [ { "id": "MARH7_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI50", "type": "external" } ], "mass": 76351.0, "length": 692, "protein_name": "E3 ubiquitin-protein ligase MARCHF7", "gene_name": "Marchf7", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase MARCHF7", "refseq_ac": [ { "id": "NP_001012087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012087", "type": "external" } ], "gene_names_uniprotkb": "Marchf7; March7", "gene_names_refseq": "Axot; March7; Marchf7", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF7; 2.3.2.27; MARCH-VII; Membrane-associated RING finger protein 7; Membrane-associated RING-CH protein VII; RING-type E3 ubiquitin transferase MARCHF7", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH7; E3 ubiquitin-protein ligase MARCHF7; MARCH-VII; RING-type E3 ubiquitin transferase MARCH7; RING-type E3 ubiquitin transferase MARCHF7; axotrophin; membrane-associated RING finger protein 7; membrane-associated RING-CH protein VII; membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase", "tax_id": 10116, "disease": "", "pathway": " (rno:311059)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23104140", "class_list": "", "function": "E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis. Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7. Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its ubiquitination and subsequent degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The results suggest that MARCH7 is involved in spermiogenesis by regulating the structural and functional integrity of the head and tail of developing spermatids., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0002643 regulation of tolerance induction;GO:1902018 negative regulation of cilium assembly;GO:0008284 positive regulation of cell population proliferation;GO:0042130 negative regulation of T cell proliferation;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XI50-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIB4-1", "uniprot_id": [ { "id": "UFSP2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIB4", "type": "external" } ], "mass": 52307.0, "length": 461, "protein_name": "Ufm1-specific protease 2", "gene_name": "Ufsp2", "organism": "Rat", "refseq_name": "ufm1-specific protease 2", "refseq_ac": [ { "id": "NP_001014164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014164", "type": "external" } ], "gene_names_uniprotkb": "Ufsp2", "gene_names_refseq": "RGD1311161; Ufsp2", "protein_names_uniprotkb": "Ufm1-specific protease 2; 3.4.22.-; UfSP2", "protein_names_refseq": "ufm1-specific protease 2", "tax_id": 10116, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); developmental and epileptic encephalopathy 106 (Disease Ontology:DOID:0070392); Beukes hip dysplasia (Disease Ontology:DOID:0111367)", "pathway": " (rno:361151)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Thiol-dependent isopeptidase that specifically cleaves UFM1, a ubiquitin-like modifier protein, from conjugated proteins, such as CD274/PD-L1, CYB5R3, DDRGK1, MRE11, RPL26/uL24, TRIP4 and RPL26/uL24. While it is also able to mediate the processing of UFM1 precursors, a prerequisite for conjugation reactions, UFSP2 mainly acts as a protein deUFMylase that mediates deconjugation of UFM1 from target proteins. Mediates deUFMylation of RPL26/uL24, a critical step to release the UFM1 ribosome E3 ligase (UREL) complex during the recycling of 60S ribosome subunits from the endoplasmic reticulum. Catalyzes deUFMylation of TRIP4, regulating intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071567 deUFMylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0006508 proteolysis;GO:1903051 negative regulation of proteolysis involved in protein catabolic process;GO:0033146 regulation of intracellular estrogen receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIB4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIC7-1", "uniprot_id": [ { "id": "TEAN2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIC7", "type": "external" } ], "mass": 24299.0, "length": 207, "protein_name": "Transcription elongation factor A N-terminal and central domain-containing protein 2", "gene_name": "Tceanc2", "organism": "Rat", "refseq_name": "transcription elongation factor A N-terminal and central domain-containing protein 2", "refseq_ac": [ { "id": "NP_001014282", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014282", "type": "external" } ], "gene_names_uniprotkb": "Tceanc2", "gene_names_refseq": "Tceanc2", "protein_names_uniprotkb": "Transcription elongation factor A N-terminal and central domain-containing protein 2", "protein_names_refseq": "transcription elongation factor A (SII) N-terminal and central domain containing 2; transcription elongation factor A N-terminal and central domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:366431)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIC7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIE2-1", "uniprot_id": [ { "id": "MTEF2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIE2", "type": "external" } ], "mass": 43344.0, "length": 385, "protein_name": "Transcription termination factor 2, mitochondrial", "gene_name": "Mterf2", "organism": "Rat", "refseq_name": "transcription termination factor 2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001014287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014287", "type": "external" } ], "gene_names_uniprotkb": "Mterf2; Mterfd3", "gene_names_refseq": "Mterf2; Mterfd3; RGD1311836", "protein_names_uniprotkb": "Transcription termination factor 2, mitochondrial; Mitochondrial transcription termination factor 2; mTERF domain-containing protein 3, mitochondrial; mTERF2", "protein_names_refseq": "MTERF domain containing 3; mTERF domain-containing protein 3, mitochondrial; transcription termination factor 2, mitochondrial precursor; transcription termination factor 2, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:366856)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds mitochondrial DNA and plays a role in the regulation of transcription of mitochondrial mRNA and rRNA species., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0006393 termination of mitochondrial transcription;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIE2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIE8-1", "uniprot_id": [ { "id": "ITM2B_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIE8", "type": "external" } ], "mass": 30314.0, "length": 266, "protein_name": "Integral membrane protein 2B", "gene_name": "Itm2b", "organism": "Rat", "refseq_name": "integral membrane protein 2B", "refseq_ac": [ { "id": "NP_001006964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006964", "type": "external" } ], "gene_names_uniprotkb": "Itm2b", "gene_names_refseq": "Bri; Itm2b; imBRI2", "protein_names_uniprotkb": "Integral membrane protein 2B; ABri23; Bri; C-terminal peptide; Immature BRI2; Mature BRI2; P23 peptide; Transmembrane protein BRI; imBRI2; mBRI2", "protein_names_refseq": "immature BRI2; integral membrane protein 2B; transmembrane protein BRI", "tax_id": 10116, "disease": "ITM2B-related cerebral amyloid angiopathy 1 (Disease Ontology:DOID:0070029); ITM2B-related cerebral amyloid angiopathy 2 (Disease Ontology:DOID:0070030); cerebral amyloid angiopathy (Disease Ontology:DOID:9246)", "pathway": " (rno:290364)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21454685;26515131;28176357;29393594;29476059;34416235", "class_list": "", "function": "A familial Danish dementia rat shows impaired presynaptic and postsynaptic glutamatergic transmission., [RefSeq, PubMed]; Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers., [UniProtKB, UniProtKB, UniProtKB]; By modulating BRI2 processing using an ADAM10 inhibitor, a dual role for BRI2 in neurite outgrowth is suggested: phosphorylated full-length BRI2 appears to be important for the formation of neuritic processes, and BRI2 NTF promotes neurite elongation., [RefSeq, PubMed]; Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42., [UniProtKB, UniProtKB, UniProtKB]; Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The resulting BRI2 brain interactome, associates this protein with neurite outgrowth and neuronal differentiation, as well as synaptic signalling and plasticity. It follows that further studies should address BRI2 particularly given its relevance to neuropathological conditions. Publication Status: Online-Only, [RefSeq, PubMed]; When BRI2 is phosphorylated a significant increase in neuronal outgrowth and differentiation is evident, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0042985 negative regulation of amyloid precursor protein biosynthetic process;GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5XIE8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIF1-1", "uniprot_id": [ { "id": "TCTA_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIF1", "type": "external" } ], "mass": 11686.0, "length": 106, "protein_name": "T-cell leukemia translocation-altered gene protein homolog", "gene_name": "Tcta", "organism": "Rat", "refseq_name": "T-cell leukemia translocation-altered gene protein homolog isoform 2", "refseq_ac": [ { "id": "NP_001014027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014027", "type": "external" } ], "gene_names_uniprotkb": "Tcta", "gene_names_refseq": "Tcta", "protein_names_uniprotkb": "T-cell leukemia translocation-altered gene protein homolog", "protein_names_refseq": "T-cell leukemia translocation-altered gene protein homolog isoform 2; T-cell leukemia translocation-altered gene protein homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:306587)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be required for cellular fusion during osteoclastogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0072675 osteoclast fusion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIF1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIM9-1", "uniprot_id": [ { "id": "TCPB_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIM9", "type": "external" } ], "mass": 57458.0, "length": 535, "protein_name": "T-complex protein 1 subunit beta", "gene_name": "Cct2", "organism": "Rat", "refseq_name": "T-complex protein 1 subunit beta", "refseq_ac": [ { "id": "NP_001005905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005905", "type": "external" } ], "gene_names_uniprotkb": "Cct2; Cctb", "gene_names_refseq": "Cct2", "protein_names_uniprotkb": "T-complex protein 1 subunit beta; 3.6.1.-; CCT-beta; TCP-1-beta", "protein_names_refseq": "CCT-beta; T-complex protein 1 subunit beta; TCP-1-beta; chaperonin containing TCP1, subunit 2 (beta)", "tax_id": 10116, "disease": "Leber congenital amaurosis (Disease Ontology:DOID:14791); candidiasis (Disease Ontology:DOID:1508)", "pathway": " (rno:299809); (R-RNO-390471); (R-RNO-5620922); (R-RNO-6798695); (R-RNO-6814122); (R-RNO-9013418); (R-RNO-9013422)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "18683930", "class_list": "", "function": "Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005874 microtubule;GO:0044297 cell body;GO:0005832 chaperonin-containing T-complex;GO:0002199 zona pellucida receptor complex", "go_biological_process": "GO:0090666 scaRNA localization to Cajal body;GO:0007339 binding of sperm to zona pellucida;GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0050821 protein stabilization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5XIM9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIP4-1", "uniprot_id": [ { "id": "UBQLN_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIP4", "type": "external" } ], "mass": 67794.0, "length": 612, "protein_name": "Ubiquilin-like protein", "gene_name": "Ubqlnl", "organism": "Rat", "refseq_name": "ubiquilin-like protein", "refseq_ac": [ { "id": "NP_001013921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013921", "type": "external" } ], "gene_names_uniprotkb": "Ubqlnl", "gene_names_refseq": "RGD1307202; Ubqlnl", "protein_names_uniprotkb": "Ubiquilin-like protein", "protein_names_refseq": "ubiquilin-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:293287)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIP4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIQ5-1", "uniprot_id": [ { "id": "SDA1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIQ5", "type": "external" } ], "mass": 79633.0, "length": 686, "protein_name": "Protein SDA1 homolog", "gene_name": "Sdad1", "organism": "Rat", "refseq_name": "protein SDA1 homolog", "refseq_ac": [ { "id": "NP_001006959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006959", "type": "external" } ], "gene_names_uniprotkb": "Sdad1", "gene_names_refseq": "Sdad1", "protein_names_uniprotkb": "Protein SDA1 homolog; SDA1 domain-containing protein 1", "protein_names_refseq": "SDA1 domain-containing protein 1; protein SDA1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:289504)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;31026094", "class_list": "", "function": "Long non-coding RNA small nucleolar RNA host gene 7 facilitates cardiac hypertrophy via stabilization of SDA1 domain containing 1 mRNA., [RefSeq, PubMed]; Required for 60S pre-ribosomal subunits export to the cytoplasm., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0015031 protein transport;GO:0042273 ribosomal large subunit biogenesis;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XIQ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIS9-1", "uniprot_id": [ { "id": "KPCD2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIS9", "type": "external" } ], "mass": 96497.0, "length": 875, "protein_name": "Serine/threonine-protein kinase D2", "gene_name": "Prkd2", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase D2", "refseq_ac": [ { "id": "NP_001013917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013917", "type": "external" } ], "gene_names_uniprotkb": "Prkd2", "gene_names_refseq": "Prkd2; RGD1308054", "protein_names_uniprotkb": "Serine/threonine-protein kinase D2; 2.7.11.13; nPKC-D2", "protein_names_refseq": "nPKC-D2; serine/threonine-protein kinase D2", "tax_id": 10116, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (rno:292658)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;27369082", "class_list": "", "function": "Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-718 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B. In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77. Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation. During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens. In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway. During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane. Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis. In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN. Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells., [UniProtKB]; SiRNA-mediated knockdown of PKD1, PKD2, and PKD3 markedly attenuated YAP nuclear-cytoplasmic shuttling, phosphorylation at Ser(127), and induction of Ctgf and Areg expression in response to GPCR activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0070232 regulation of T cell apoptotic process;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0001525 angiogenesis;GO:0006468 protein phosphorylation;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XIS9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIV0-1", "uniprot_id": [ { "id": "TET5C_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIV0", "type": "external" } ], "mass": 44799.0, "length": 391, "protein_name": "Terminal nucleotidyltransferase 5C", "gene_name": "Tent5c", "organism": "Rat", "refseq_name": "terminal nucleotidyltransferase 5C", "refseq_ac": [ { "id": "NP_001014063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014063", "type": "external" } ], "gene_names_uniprotkb": "Tent5c; Fam46c", "gene_names_refseq": "Fam46c; Tent5c", "protein_names_uniprotkb": "Terminal nucleotidyltransferase 5C; 2.7.7.19", "protein_names_refseq": "family with sequence similarity 46, member C; protein FAM46C; putative nucleotidyltransferase FAM46C; terminal nucleotidyltransferase 5C", "tax_id": 10116, "disease": "", "pathway": " (rno:310721)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression. Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0048255 mRNA stabilization;GO:0045596 negative regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIV0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIW8-1", "uniprot_id": [ { "id": "SNUT1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIW8", "type": "external" } ], "mass": 91011.0, "length": 806, "protein_name": "U4/U6.U5 tri-snRNP-associated protein 1", "gene_name": "Sart1", "organism": "Rat", "refseq_name": "U4/U6.U5 tri-snRNP-associated protein 1", "refseq_ac": [ { "id": "NP_113784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113784", "type": "external" } ], "gene_names_uniprotkb": "Sart1", "gene_names_refseq": "Sart1", "protein_names_uniprotkb": "U4/U6.U5 tri-snRNP-associated protein 1; SART-1; Squamous cell carcinoma antigen recognized by T-cells 1; rSART-1", "protein_names_refseq": "SART-1; SART1, U4/U6.U5 tri-snRNP-associated protein 1; U4/U6.U5 tri-snRNP-associated protein 1; rSART-1; squamous cell carcinoma antigen recognized by T cells 1", "tax_id": 10116, "disease": "", "pathway": " (rno:29678)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;9765622", "class_list": "", "function": "Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z314", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000481 maturation of 5S rRNA;GO:0045585 positive regulation of cytotoxic T cell differentiation;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XIW8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62666-1", "uniprot_id": [ { "id": "VACHT_RAT", "url": "https://www.uniprot.org/uniprot/Q62666", "type": "external" } ], "mass": 56537.0, "length": 530, "protein_name": "Vesicular acetylcholine transporter", "gene_name": "Slc18a3", "organism": "Rat", "refseq_name": "vesicular acetylcholine transporter", "refseq_ac": [ { "id": "NP_113851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113851", "type": "external" } ], "gene_names_uniprotkb": "Slc18a3; Vacht; Vat", "gene_names_refseq": "Slc18a3; VACht; rVAT", "protein_names_uniprotkb": "Vesicular acetylcholine transporter; Solute carrier family 18 member 3; VAChT; rVAT", "protein_names_refseq": "solute carrier family 18 (vesicular acetylcholine transporter), member 3; solute carrier family 18 (vesicular acetylcholine), member 3; solute carrier family 18 (vesicular monoamine) member 3; solute carrier family 18, member 3; vesicular acetylcholine transporter", "tax_id": 10116, "disease": "congenital myasthenic syndrome 21 (Disease Ontology:DOID:0110672); Alzheimer's disease (Disease Ontology:DOID:10652); Huntington's disease (Disease Ontology:DOID:12858); asthma (Disease Ontology:DOID:2841); bladder disease (Disease Ontology:DOID:365)", "pathway": " (rno:60422); (R-RNO-264642); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10769030;15366926;15485505;21557989;34071104;7938002;8071310;8071313;9182805", "class_list": "", "function": "Electrogenic antiporter that exchanges one cholinergic neurotransmitter, acetylcholine or choline, with two intravesicular protons across the membrane of synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to store neurotransmitters inside the vesicles prior to their release via exocytosis (PubMed:15485505, PubMed:8071310). Determines cholinergic vesicular quantal size at presynaptic nerve terminals in developing neuro-muscular junctions with an impact on motor neuron differentiation and innervation pattern (PubMed:9182805). Part of forebrain cholinergic system, regulates hippocampal synapse transmissions that underlie spatial memory formation (By similarity). Can transport serotonin., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]; Expression of Cholinergic Markers and Characterization of Splice Variants during Ontogenesis of Rat Dorsal Root Ganglia Neurons. Publication Status: Online-Only, [RefSeq, PubMed]; VACHT is inserted into the presynaptic membrane during synaptic vesicles' exocytosis, removed during their endocytotic recycling, and plays a role in non-quantal secretion of acetylcholine. Erratum:[Neuroscience. 2011 Sep 29;192:806], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 1, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 1, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q64351", "ec_number_list": [], "go_molecular_function": "GO:0005277 acetylcholine transmembrane transporter activity;GO:0015311 monoamine:proton antiporter activity;GO:0005278 acetylcholine:proton antiporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0031594 neuromuscular junction;GO:0043195 terminal bouton;GO:0043204 perikaryon", "go_biological_process": "GO:0015870 acetylcholine transport;GO:0045471 response to ethanol;GO:1900273 positive regulation of long-term synaptic potentiation;GO:0007268 chemical synaptic transmission;GO:0014057 positive regulation of acetylcholine secretion, neurotransmission", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q62666-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000001010001.011.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62720-1", "uniprot_id": [ { "id": "ZNT1_RAT", "url": "https://www.uniprot.org/uniprot/Q62720", "type": "external" } ], "mass": 55143.0, "length": 507, "protein_name": "Proton-coupled zinc antiporter SLC30A1", "gene_name": "Slc30a1", "organism": "Rat", "refseq_name": "proton-coupled zinc antiporter SLC30A1", "refseq_ac": [ { "id": "NP_074044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_074044", "type": "external" } ], "gene_names_uniprotkb": "Slc30a1; Znt1", "gene_names_refseq": "Slc30a1", "protein_names_uniprotkb": "Proton-coupled zinc antiporter SLC30A1; Solute carrier family 30 member 1; Zinc transporter 1; ZnT-1", "protein_names_refseq": "proton-coupled zinc antiporter SLC30A1; solute carrier family 30 (zinc transporter), member 1; zinc transporter 1; znT-1", "tax_id": 10116, "disease": "", "pathway": " (rno:58976); (R-RNO-435368)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "15378655;15451416;16741752;19095042;19767393;21454685;24807795;24951051;25319628;26463958;28091657;7882967;9560190", "class_list": "", "function": "Hypoxia/reoxygenation dramatically decreased ZnT-1 expression in rat astrocytes., [RefSeq, PubMed]; Our findings therefore indicate that ZnT-1 modulates the permeation of cations through LTCC, thereby, regulating cation homeostasis through this pathway., [RefSeq, PubMed]; The elevated ZnT-1 expression following zinc priming or after heterologous expression of ZnT-1 may explain the reduced zinc accumulation and the subsequent reduction in sensitivity toward toxic zinc levels. [ZnT-1] Erratum:[Glia. 2004 Dec;48(4):346], [RefSeq, PubMed]; These data indicate that maternal zinc deficiency resulted in an elevated incidence of fetal heart malformations, which was associated with significant decreases in placental MT-1 and ZnT-1 mRNA expressions, [RefSeq, PubMed]; ZNT-1 interacts with GluN2A-containing NMDA receptors at the glutamatergic synapse. This complex is regulated by synaptic plasticity induction. ZNT-1 expression modulation in hippocampal neurons shrank dendritic spines and reduced GluN2A surface levels., [RefSeq, PubMed]; Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:19095042, PubMed:24951051, PubMed:7882967, PubMed:28091657). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (PubMed:15378655, PubMed:16741752, PubMed:19767393, PubMed:28091657). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (By similarity). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (By similarity). Down-regulates the activity of transcription factors induced by zinc and cytokines (By similarity). Also functions as a copper transporter, facilitating the entry of copper into cells, which is crucial for copper-induced cell death (cuproptosis) (By similarity). Acts as a Zn(2+)/Ca(2+) exchanger, exporting zinc in exchange for calcium influx (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0046872 metal ion binding;GO:0019855 calcium channel inhibitor activity;GO:0015368 calcium:monoatomic cation antiporter activity;GO:0140826 zinc:proton antiporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0010312 detoxification of zinc ion;GO:0071577 zinc ion transmembrane transport;GO:0090281 negative regulation of calcium ion import;GO:0006829 zinc ion transport;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q62720-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62733-1", "uniprot_id": [ { "id": "LAP2_RAT", "url": "https://www.uniprot.org/uniprot/Q62733", "type": "external" } ], "mass": 50278.0, "length": 452, "protein_name": "Lamina-associated polypeptide 2, isoform beta", "gene_name": "Tmpo", "organism": "Rat", "refseq_name": "lamina-associated polypeptide 2, isoform beta isoform 2", "refseq_ac": [ { "id": "NP_037019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037019", "type": "external" } ], "gene_names_uniprotkb": "Tmpo; Lap2", "gene_names_refseq": "LAP2; Tmpo", "protein_names_uniprotkb": "Lamina-associated polypeptide 2, isoform beta; TP beta; Thymopoietin isoform beta", "protein_names_refseq": "TP beta; Thymopoietin (lamina associated polypeptide 2); lamina-associated polypeptide 2, isoform beta isoform 2; lamina-associated polypeptide 2", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "15546916;16760672;22673903;29393594;7737115", "class_list": "", "function": "Binds directly to lamin B1 and chromosomes in a mitotic phosphorylation-regulated manner. May play an important role in nuclear envelope reassembly at the end of mitosis and/or anchoring of the nuclear lamina and interphase chromosomes to the nuclear envelope., [UniProtKB]; In agreement with its regulation by E2F, LAP2alpha over expression in primary tumors was found to be correlated with tumor proliferation rate, [RefSeq, PubMed]; LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0005521 lamin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0031965 nuclear membrane;GO:0000785 chromatin;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62733-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62789-1", "uniprot_id": [ { "id": "UD2B7_RAT", "url": "https://www.uniprot.org/uniprot/Q62789", "type": "external" } ], "mass": 60089.0, "length": 530, "protein_name": "UDP-glucuronosyltransferase 2B7", "gene_name": "Ugt2b7", "organism": "Rat", "refseq_name": "UDP-glucuronosyltransferase 2B7 precursor", "refseq_ac": [ { "id": "NP_775445", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775445", "type": "external" } ], "gene_names_uniprotkb": "Ugt2b7; Ugt2b8", "gene_names_refseq": "UDPGT 2B7; Ugt2b7; Ugt2b8", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 2B7; 2.4.1.17; UDPGT 2B7; UGT2B-RH4; UGT2B7", "protein_names_refseq": "UDP glucuronosyltransferase 2 family, polypeptide B7; UDP-glucuronosyltransferase 2B7 precursor; UDP-glucuronosyltransferase 2B7; UDP-glucuronosyltransferase 2B8; UDPGT 2B8; UGT2B-RH4", "tax_id": 10116, "disease": "", "pathway": " (rno:286989); (R-RNO-156588); (R-RNO-9749641); (R-RNO-9757110)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "22028316;28770824;30347696", "class_list": "glycogene;glycosyltransferase", "function": "Acute liver failure significantly increases the oral plasma exposure of zidovudine in rats, a result partly attributed to the impaired function and expression of hepatic UGT2B7 and intestinal P-gp., [RefSeq, PubMed]; Data suggest that UGT2B7 is the predominant activity in liver microsomes for haloperidol O-glucuronidation (in both rat and human)., [RefSeq, PubMed]; Meanwhile, only mitragynine and zerumbone inhibited ZDV(probe substrate to determine UGT2B7 activity) glucuronidation in RLM with IC50 values of 51.20 +/- 5.95 muM and 8.14 +/- 2.12 microM, respectively, indicating a difference between the human and rat microsomal model so caution must be exercised when extrapolating inhibitory metabolic data from rats to humans. Publication Status: Online-Only, [RefSeq, PubMed]; UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens). Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, 20-HETE, PGE2, PGB1 and F2-isoprostanes (8-iso-PGF2alpha and 5-epi-5-F2t-IsoP). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II. Also metabolizes mycophenolate, an immunosuppressive agent., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" } ], "go_molecular_function": "GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:1902494 catalytic complex", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0006805 xenobiotic metabolic process;GO:0008209 androgen metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62789-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62862-1", "uniprot_id": [ { "id": "MP2K5_RAT", "url": "https://www.uniprot.org/uniprot/Q62862", "type": "external" } ], "mass": 50198.0, "length": 448, "protein_name": "Dual specificity mitogen-activated protein kinase kinase 5", "gene_name": "Map2k5", "organism": "Rat", "refseq_name": "dual specificity mitogen-activated protein kinase kinase 5 isoform a", "refseq_ac": [ { "id": "NP_001029159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029159", "type": "external" } ], "gene_names_uniprotkb": "Map2k5; Mek5; Mkk5; Prkmk5", "gene_names_refseq": "Map2k5; Mek5", "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase 5; 2.7.12.2; MAP kinase kinase 5; MAPK/ERK kinase 5; MAPKK 5; MEK 5", "protein_names_refseq": "MAP kinase kinase 5; MAPK/ERK kinase 5; MAPKK 5; MEK 5; dual specificity mitogen-activated protein kinase kinase 5 isoform a; dual specificity mitogen-activated protein kinase kinase 5", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (rno:29568)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19484198;20607863;20724525;25666619;7499418", "class_list": "", "function": "Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (PubMed:20724525)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Data indicate that NSC23766-mediated Rac inhibition induces cerebellar granule neurons (CGNs) apoptosis through deactivation of prosurvival MAP Kinase Kinase 5 MEK5/ERK5 kinase signaling., [RefSeq, PubMed]; Several binding motifs for heat shock factor are dispersed in the mouse and rat promoter, and temperature shock transiently enhanced the MAP-kinase-activated kinase 5 transcript levels., [RefSeq, PubMed]; The p38-mitogen-activated protein kinase activated protein kinase 2 (MK2) pathway is a component of the signaling cascade regulating oligodendrocyte differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62863;Q62864", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004707 MAP kinase activity", "go_cellular_component": "GO:0005819 spindle;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production;GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0070375 ERK5 cascade;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62862-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62875-1", "uniprot_id": [ { "id": "MILR1_RAT", "url": "https://www.uniprot.org/uniprot/Q62875", "type": "external" } ], "mass": 27459.0, "length": 248, "protein_name": "Allergin-1", "gene_name": "Milr1", "organism": "Rat", "refseq_name": "allergin-1 isoform 1", "refseq_ac": [ { "id": "NP_067596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067596", "type": "external" } ], "gene_names_uniprotkb": "Milr1; Mca32", "gene_names_refseq": "Mca32; Milr1", "protein_names_uniprotkb": "Allergin-1; Allergy inhibitory receptor 1; MCA-32; Mast cell Ag-32; Mast cell antigen 32; Mast cell immunoglobulin-like receptor 1", "protein_names_refseq": "MCA-32; allergin-1 isoform 1; allergin-1; allergy inhibitory receptor 1; mast cell Ag-32; mast cell antigen 32; surface protein MCA-32", "tax_id": 10116, "disease": "", "pathway": " (rno:59105)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7499870", "class_list": "", "function": "Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0043303 mast cell degranulation;GO:0033004 negative regulation of mast cell activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62875-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62975-1", "uniprot_id": [ { "id": "ZPI_RAT", "url": "https://www.uniprot.org/uniprot/Q62975", "type": "external" } ], "mass": 50244.0, "length": 436, "protein_name": "Protein Z-dependent protease inhibitor", "gene_name": "Serpina10", "organism": "Rat", "refseq_name": "protein Z-dependent protease inhibitor precursor", "refseq_ac": [ { "id": "NP_598301", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598301", "type": "external" } ], "gene_names_uniprotkb": "Serpina10; Rasp1; Zpi", "gene_names_refseq": "Rasp1; Serpina10", "protein_names_uniprotkb": "Protein Z-dependent protease inhibitor; PZ-dependent protease inhibitor; PZI; RASP-1; Regeneration-associated serpin 1; Serpin A10", "protein_names_refseq": "PZ-dependent protease inhibitor; PZI; RASP-1; plasma protein associated with liver regeneration; protein Z-dependent protease inhibitor precursor; protein Z-dependent protease inhibitor-like; protein Z-dependent protease inhibitor; regeneration-associated serpin 1; serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10; serpin A10; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10; serpin peptidase inhibitor, clade A, member 10", "tax_id": 10116, "disease": "small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); thrombophilia (Disease Ontology:DOID:2452)", "pathway": " (rno:171154); (R-RNO-381426); (R-RNO-8957275); (R-RNO-9769739)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "21454685;8670294", "class_list": "", "function": "Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors (By similarity)., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q5M8C2", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007596 blood coagulation;GO:0097421 liver regeneration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62975-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62981-1", "uniprot_id": [ { "id": "ZN260_RAT", "url": "https://www.uniprot.org/uniprot/Q62981", "type": "external" } ], "mass": 46584.0, "length": 407, "protein_name": "Zinc finger protein 260", "gene_name": "Znf260", "organism": "Rat", "refseq_name": "zinc finger protein 260", "refseq_ac": [ { "id": "NP_059060", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059060", "type": "external" } ], "gene_names_uniprotkb": "Znf260; Pex1; Zfp260", "gene_names_refseq": "OZF; POZF-1; Zfp260; Znf146; Znf260", "protein_names_uniprotkb": "Zinc finger protein 260; POZF-1; Pancreas-only zinc finger protein 1; Zfp-260", "protein_names_refseq": "pancreas-only zinc finger protein 1; zinc finger protein 146; zinc finger protein 260", "tax_id": 10116, "disease": "", "pathway": " (rno:53982)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16166646", "class_list": "", "function": "Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator., [UniProtKB, PubMed]; Zfp260 is a novel transcriptional regulator in normal and pathological heart development and a nuclear effector of alpha1-adrenergic signaling, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q499Q6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62981-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63257-1", "uniprot_id": [ { "id": "IL4RA_RAT", "url": "https://www.uniprot.org/uniprot/Q63257", "type": "external" } ], "mass": 86719.0, "length": 801, "protein_name": "Interleukin-4 receptor subunit alpha", "gene_name": "Il4r", "organism": "Rat", "refseq_name": "interleukin-4 receptor subunit alpha precursor", "refseq_ac": [ { "id": "NP_596871", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596871", "type": "external" } ], "gene_names_uniprotkb": "Il4r; Il4ra", "gene_names_refseq": "Il4ra; Il4r", "protein_names_uniprotkb": "Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA", "protein_names_refseq": "IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; interleukin 4 receptor, alpha; interleukin-4 receptor alpha chain; interleukin-4 receptor subunit alpha precursor; interleukin-4 receptor subunit alpha", "tax_id": 10116, "disease": "primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); stroke (Disease Ontology:DOID:0051061); allergic conjunctivitis (Disease Ontology:DOID:11204); esophagitis (Disease Ontology:DOID:11963); pancreatic cancer (Disease Ontology:DOID:1793); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); interstitial lung disease (Disease Ontology:DOID:3082); atopic dermatitis (Disease Ontology:DOID:3310); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); cholangiocarcinoma (Disease Ontology:DOID:4947); myocardial infarction (Disease Ontology:DOID:5844); acne (Disease Ontology:DOID:6543); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); renal tuberculosis (Disease Ontology:DOID:9733)", "pathway": " (rno:25084); (R-RNO-6785807)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10525162;17675186;25411311;7640343", "class_list": "", "function": "Isoform 2 (soluble form) inhibits IL4-induced spleen cell proliferation., [UniProtKB]; Our results suggest that oxidative stress may up-regulate IL-4 gene expression in mast cells via a decrease in HDAC activity., [RefSeq, PubMed]; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 5, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1W8;Q9WTM8", "ec_number_list": [], "go_molecular_function": "GO:0004913 interleukin-4 receptor activity;GO:0044877 protein-containing complex binding;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0005898 interleukin-13 receptor complex", "go_biological_process": "GO:0035771 interleukin-4-mediated signaling pathway;GO:0043032 positive regulation of macrophage activation;GO:0006955 immune response;GO:0042127 regulation of cell population proliferation;GO:0032722 positive regulation of chemokine production", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63257-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63302-1", "uniprot_id": [ { "id": "TFEC_RAT", "url": "https://www.uniprot.org/uniprot/Q63302", "type": "external" } ], "mass": 35175.0, "length": 317, "protein_name": "Transcription factor EC", "gene_name": "Tfec", "organism": "Rat", "refseq_name": "transcription factor EC", "refseq_ac": [ { "id": "NP_071774", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071774", "type": "external" } ], "gene_names_uniprotkb": "Tfec; Tcfec", "gene_names_refseq": "Tcfec; Tfec", "protein_names_uniprotkb": "Transcription factor EC; TFE-C; rTFEC", "protein_names_refseq": "TFE-C; rTFEC; transcription factor EC", "tax_id": 10116, "disease": "lysosomal storage disease (Disease Ontology:DOID:3211)", "pathway": " (rno:26296)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8336698", "class_list": "", "function": "Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence. Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63302-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63341-1", "uniprot_id": [ { "id": "MMP12_RAT", "url": "https://www.uniprot.org/uniprot/Q63341", "type": "external" } ], "mass": 53738.0, "length": 465, "protein_name": "Macrophage metalloelastase", "gene_name": "Mmp12", "organism": "Rat", "refseq_name": "macrophage metalloelastase preproprotein", "refseq_ac": [ { "id": "NP_446415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446415", "type": "external" } ], "gene_names_uniprotkb": "Mmp12; Mmel", "gene_names_refseq": "Mme; Mmp12", "protein_names_uniprotkb": "Macrophage metalloelastase; 3.4.24.65; MME; MMP-12; Matrix metalloproteinase-12", "protein_names_refseq": "MMP-12; macrophage metalloelastase preproprotein; macrophage metalloelastase; matrix metalloproteinase-12", "tax_id": 10116, "disease": "crescentic glomerulonephritis (Disease Ontology:DOID:13139); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Marfan syndrome (Disease Ontology:DOID:14323); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); coronary aneurysm (Disease Ontology:DOID:3362); coronary artery disease (Disease Ontology:DOID:3393); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); esophagus adenocarcinoma (Disease Ontology:DOID:4914); abdominal aortic aneurysm (Disease Ontology:DOID:7693); Barrett's esophagus (Disease Ontology:DOID:9206)", "pathway": " (rno:117033); (R-RNO-1442490); (R-RNO-1474228)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "27807143;29428638;36283468", "class_list": "", "function": "Elevated 20-hydroxyeicosatetraeonic acid in metabolic syndrome increases matrix metalloproteinase 12 (MMP12) activation leading to increased degradation of elastin, increased large artery stiffness and increased systolic blood pressure. Erratum:[J Mol Cell Cardiol. 2018 Aug;121:308. doi: 10.1016/j.yjmcc.2018.03.015. PMID: 29625729], [RefSeq, PubMed]; In the present report, hypoxia is shown to activate a HIF-KDM3A-MMP12 signaling cascade that promotes trophoblast invasion and trophoblast-directed uterine spiral artery remodeling., [RefSeq, PubMed]; May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity)., [UniProtKB]; The interplay between MMP-12 and t-PA in the brain after ischemic stroke., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5I0P0", "ec_number_list": [ { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.24.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0005518 collagen binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031012 extracellular matrix", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0050691 regulation of defense response to virus by host;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006508 proteolysis;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63341-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63344-1", "uniprot_id": [ { "id": "MOT2_RAT", "url": "https://www.uniprot.org/uniprot/Q63344", "type": "external" } ], "mass": 53043.0, "length": 489, "protein_name": "Monocarboxylate transporter 2", "gene_name": "Slc16a7", "organism": "Rat", "refseq_name": "monocarboxylate transporter 2", "refseq_ac": [ { "id": "NP_058998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058998", "type": "external" } ], "gene_names_uniprotkb": "Slc16a7; Mct2", "gene_names_refseq": "Mct2; Slc16a7", "protein_names_uniprotkb": "Monocarboxylate transporter 2; MCT 2; Solute carrier family 16 member 7", "protein_names_refseq": "MCT 2; monocarboxylate transporter 2; solute carrier family 16 (monocarboxylate transporter), member 7; solute carrier family 16 (monocarboxylic acid transporters), member 7; solute carrier family 16, member 7 (monocarboxylic acid transporter 2)", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); bone disease (Disease Ontology:DOID:0080001); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); colon cancer (Disease Ontology:DOID:219); high grade glioma (Disease Ontology:DOID:3070); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); liver cirrhosis (Disease Ontology:DOID:5082); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (rno:29735); (R-RNO-433692)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10417314;12966567;15917240;20695846;22673903;24610532;25827488;26831515;28388627;30143583;9182702;9482213", "class_list": "", "function": "Data not only demonstrate that glucose-derived lactate is locally produced following neuronal activation but also suggest that its use by neurons via MCT2 is probably essential to maintain synaptic activity within the barrel cortex Publication Status: Online-Only, [RefSeq, PubMed]; MCT2 increased in the hippocampus immediately after exercise and in the cortex and hypothalamus 5-24 h postexercise., [RefSeq, PubMed]; MPC inhibition is the most sensitive anti-tumour target for LND, with additional inhibitory effects on MCT-mediated L-lactic acid efflux and glutamine/glutamate oxidation., [RefSeq, PubMed]; Monocarboxylate transporter Slc16a7/MCT2-like immunoreactivity is expressed along the medial and ventral border of the ventricle in the medial septum and habenula before birth., [RefSeq, PubMed]; Monocarboxylate transporter-2-knockout, which blocked the lactate shuttle in neurons, showed a remarkable decrease in the length of axons and dendrites. We further demonstrated that Akt activity was decreased while glycogen synthase kinase 3beta (GSK3beta) activity was increased after astrocytic glycogen phosphorylase blockade. Additionally, GSK3betaSer9 mutation reversed neurite growth failure caused by DAB and isofag... Publication Status: Online-Only, [RefSeq, PubMed]; Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:10417314, PubMed:20695846). Dimerization is functionally required and both subunits work cooperatively in transporting substrate (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Resistance to oxygen- and glucose-deprivation injury in astrocyte-neuron co-cultures occurs via an MCT-dependent mechanism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63649;Q66HS9", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0015293 symporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity;GO:0050833 pyruvate transmembrane transporter activity;GO:0015129 lactate transmembrane transporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0035873 lactate transmembrane transport;GO:1901475 pyruvate transmembrane transport;GO:0035879 plasma membrane lactate transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q63344-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63396-1", "uniprot_id": [ { "id": "TCP4_RAT", "url": "https://www.uniprot.org/uniprot/Q63396", "type": "external" } ], "mass": 14441.0, "length": 127, "protein_name": "Activated RNA polymerase II transcriptional coactivator p15", "gene_name": "Sub1", "organism": "Rat", "refseq_name": "activated RNA polymerase II transcriptional coactivator p15", "refseq_ac": [ { "id": "NP_001009618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009618", "type": "external" } ], "gene_names_uniprotkb": "Sub1; Pc4; Rpo2tc1", "gene_names_refseq": "Rpo2tc1; Sub1", "protein_names_uniprotkb": "Activated RNA polymerase II transcriptional coactivator p15; PC4; Positive cofactor 4; SUB1 homolog; p14", "protein_names_refseq": "PC4; RNA polymerase II transcriptional coactivator; SUB1 homolog, transcriptional regulator; activated RNA polymerase II transcriptional coactivator p15; p14; pR-ET2 encoded oncodevelopmental protein; positive cofactor 4", "tax_id": 10116, "disease": "", "pathway": " (rno:192269)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;29393594;6208900", "class_list": "", "function": "General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M805", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding;GO:0003690 double-stranded DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0051053 negative regulation of DNA metabolic process;GO:0001111 RNA polymerase II promoter clearance", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63396-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63548-1", "uniprot_id": [ { "id": "SEM3A_RAT", "url": "https://www.uniprot.org/uniprot/Q63548", "type": "external" } ], "mass": 88808.0, "length": 772, "protein_name": "Semaphorin-3A", "gene_name": "Sema3a", "organism": "Rat", "refseq_name": "semaphorin-3A precursor", "refseq_ac": [ { "id": "NP_059006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059006", "type": "external" } ], "gene_names_uniprotkb": "Sema3a", "gene_names_refseq": "Sema3a", "protein_names_uniprotkb": "Semaphorin-3A; Sema III; Semaphorin III", "protein_names_refseq": "sema III; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; sema domain, immunoglobulin domain (Ig), short basic domain, sec; semaphorin III; semaphorin-3A precursor", "tax_id": 10116, "disease": "hypogonadotropic hypogonadism 16 with or without anosmia (Disease Ontology:DOID:0090080); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:29751); (R-RNO-399954); (R-RNO-399955); (R-RNO-399956)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "28270793;32242249;33566267;37128697;37864189;38430015;8915837", "class_list": "", "function": "May be involved in guiding growing axons towards their targets by forming a molecular boundary that instructs axons to engage in the formation of specific nerve tracts. Binds to neuropilin. Involved in the development of the olfactory system and in neuronal control of puberty (By similarity)., [UniProtKB]; Neuropilin-1 receptor in the rapid and selective estrogen-induced neurovascular remodeling of rat uterus. Erratum:[Cell Tissue Res. 2020 Aug;381(2):379. doi: 10.1007/s00441-020-03230-9. PMID: 32542406], [RefSeq, PubMed]; Pure platelet-rich plasma promotes semaphorin-3A expression: a novel insight to ameliorate intervertebral disk degeneration in vitro. Publication Status: Online-Only, [RefSeq, PubMed]; Sema3A ameliorates the pathological progression of osteoarthritis by modulating mitochondrial damage in chondrocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Sema3A inactivates the ERK/JNK signalling pathways to alleviate inflammation and oxidative stress in lipopolysaccharide-stimulated rat endothelial cells and lung tissues., [RefSeq, PubMed]; Semaphorin 3A promotes the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells in inflammatory environments by suppressing the Wnt/beta-catenin signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:2000020 positive regulation of male gonad development;GO:0010633 negative regulation of epithelial cell migration;GO:0097490 sympathetic neuron projection extension;GO:0097491 sympathetic neuron projection guidance;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63548-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63556-1", "uniprot_id": [ { "id": "SPA3M_RAT", "url": "https://www.uniprot.org/uniprot/Q63556", "type": "external" } ], "mass": 46095.0, "length": 412, "protein_name": "Serine protease inhibitor A3M", "gene_name": "Serpina3m", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Serpina3m", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine protease inhibitor A3M; SPI-2.4; Serine protease inhibitor 2.4; Serpin A3M", "protein_names_refseq": "", "tax_id": 10116, "disease": "adult respiratory distress syndrome (Disease Ontology:DOID:11394); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); cystic fibrosis (Disease Ontology:DOID:1485); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung adenocarcinoma (Disease Ontology:DOID:3910); vasculitis (Disease Ontology:DOID:865)", "pathway": " (rno:299276)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15638460", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0034097 response to cytokine", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63556-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63624-1", "uniprot_id": [ { "id": "SFR19_RAT", "url": "https://www.uniprot.org/uniprot/Q63624", "type": "external" } ], "mass": 133856.0, "length": 1258, "protein_name": "Splicing factor, arginine/serine-rich 19", "gene_name": "Scaf1", "organism": "Rat", "refseq_name": "splicing factor, arginine/serine-rich 19", "refseq_ac": [ { "id": "NP_001387752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001387752", "type": "external" } ], "gene_names_uniprotkb": "Scaf1; Sfrs19", "gene_names_refseq": "Scaf1; Sr-a1", "protein_names_uniprotkb": "Splicing factor, arginine/serine-rich 19; CTD-binding SR-like protein rA1; SR-related and CTD-associated factor 1", "protein_names_refseq": "CTD-binding SR-like protein rA1; CTD-binding SR-like rA1; SR-related and CTD-associated factor 1; serine arginine-rich pre-mRNA splicing factor SR-A1; splicing factor, arginine/serine-rich 19", "tax_id": 10116, "disease": "end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:56081)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;8692929", "class_list": "", "function": "May function in pre-mRNA splicing., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0019904 protein domain specific binding;GO:0099122 RNA polymerase II C-terminal domain binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63624-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63627-1", "uniprot_id": [ { "id": "SCAF4_RAT", "url": "https://www.uniprot.org/uniprot/Q63627", "type": "external" } ], "mass": 130953.0, "length": 1200, "protein_name": "SR-related and CTD-associated factor 4", "gene_name": "Scaf4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Scaf4; Sfrs15", "gene_names_refseq": "", "protein_names_uniprotkb": "SR-related and CTD-associated factor 4; CTD-binding SR-like protein RA4; Splicing factor, arginine/serine-rich 15", "protein_names_refseq": "", "tax_id": 10116, "disease": "Fliedner-Zweier syndrome (Disease Ontology:DOID:0070653); syndrome (Disease Ontology:DOID:225)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "22673903;8692929", "class_list": "", "function": "Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF8, also acts as a suppressor of transcriptional readthrough., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "F1LSM7", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:2000805 negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63627-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63769-1", "uniprot_id": [ { "id": "SRPX_RAT", "url": "https://www.uniprot.org/uniprot/Q63769", "type": "external" } ], "mass": 51560.0, "length": 464, "protein_name": "Sushi repeat-containing protein SRPX", "gene_name": "Rpgr; Srpx", "organism": "Rat", "refseq_name": "sushi repeat-containing protein SRPX precursor", "refseq_ac": [ { "id": "NP_071969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071969", "type": "external" } ], "gene_names_uniprotkb": "Rpgr; Srpx; Drs; LOC134484130; Srpx", "gene_names_refseq": "Drs; Srpx", "protein_names_uniprotkb": "Sushi repeat-containing protein SRPX; DRS; Down-regulated by v-SRC", "protein_names_refseq": "down-regulated by v-src; sushi repeat-containing protein SRPX precursor; sushi repeat-containing protein SRPX; sushi-repeat-containing protein, X chromosome", "tax_id": 10116, "disease": "retinitis pigmentosa 3 (Disease Ontology:DOID:0110414); X-linked cone-rod dystrophy 1 (Disease Ontology:DOID:0111008); X-linked retinitis pigmentosa and sinorespiratory infections (Disease Ontology:DOID:0112124); X-linked atrophic macular degeneration (Disease Ontology:DOID:0112157); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (rno:64316)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8612783", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5PPK5", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005776 autophagosome;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0060244 negative regulation of cell proliferation involved in contact inhibition;GO:0006914 autophagy;GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0034976 response to endoplasmic reticulum stress;GO:0001845 phagolysosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63769-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63799-1", "uniprot_id": [ { "id": "TCEA2_RAT", "url": "https://www.uniprot.org/uniprot/Q63799", "type": "external" } ], "mass": 33528.0, "length": 299, "protein_name": "Transcription elongation factor A protein 2", "gene_name": "Tcea2", "organism": "Rat", "refseq_name": "transcription elongation factor A protein 2", "refseq_ac": [ { "id": "NP_476439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476439", "type": "external" } ], "gene_names_uniprotkb": "Tcea2; Siit1", "gene_names_refseq": "Tcea2", "protein_names_uniprotkb": "Transcription elongation factor A protein 2; Protein S-II-T1; Testis-specific S-II; Transcription elongation factor S-II protein 2; Transcription elongation factor TFIIS.l", "protein_names_refseq": "testis-specific S-II; transcription elongation factor A (SII), 2; transcription elongation factor A protein 2; transcription elongation factor S-II protein 2; transcription elongation factor TFIIS.l", "tax_id": 10116, "disease": "", "pathway": " (rno:29575)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8300645", "class_list": "", "function": "Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63799-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63965-1", "uniprot_id": [ { "id": "SFXN1_RAT", "url": "https://www.uniprot.org/uniprot/Q63965", "type": "external" } ], "mass": 35546.0, "length": 322, "protein_name": "Sideroflexin-1", "gene_name": "Sfxn1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sfxn1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sideroflexin-1; TCC; Tricarboxylate carrier protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:364678)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "38843836;8132491", "class_list": "", "function": "Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. May also transport other amino acids including alanine and cysteine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015180 L-alanine transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015194 L-serine transmembrane transporter activity;GO:0015075 monoatomic ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0015825 L-serine transport;GO:0030218 erythrocyte differentiation;GO:0006730 one-carbon metabolic process;GO:0006826 iron ion transport;GO:0015808 L-alanine transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63965-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63ZV7-1", "uniprot_id": [ { "id": "SWI5_RAT", "url": "https://www.uniprot.org/uniprot/Q63ZV7", "type": "external" } ], "mass": 10279.0, "length": 89, "protein_name": "DNA repair protein SWI5 homolog", "gene_name": "Swi5", "organism": "Rat", "refseq_name": "DNA repair protein SWI5 homolog", "refseq_ac": [ { "id": "NP_001233590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001233590", "type": "external" } ], "gene_names_uniprotkb": "Swi5; Sae3", "gene_names_refseq": "Swi5", "protein_names_uniprotkb": "DNA repair protein SWI5 homolog; Protein SAE3 homolog", "protein_names_refseq": "DNA repair protein SWI5 homolog; protein SAE3 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:499779)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032798 Swi5-Sfr1 complex", "go_biological_process": "GO:0000724 double-strand break repair via homologous recombination;GO:0071479 cellular response to ionizing radiation;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q63ZV7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63ZY7-1", "uniprot_id": [ { "id": "UXT_RAT", "url": "https://www.uniprot.org/uniprot/Q63ZY7", "type": "external" } ], "mass": 18166.0, "length": 157, "protein_name": "Protein UXT", "gene_name": "Uxt", "organism": "Rat", "refseq_name": "protein UXT", "refseq_ac": [ { "id": "NP_001006983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006983", "type": "external" } ], "gene_names_uniprotkb": "Uxt", "gene_names_refseq": "Uxt", "protein_names_uniprotkb": "Protein UXT; Ubiquitously expressed transcript protein", "protein_names_refseq": "protein UXT; ubiquitously expressed transcript protein", "tax_id": 10116, "disease": "", "pathway": " (rno:299313)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription. Together with URI1, associates with chromatin to the NKX3-1 promoter region. Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm. May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005856 cytoskeleton", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0000226 microtubule cytoskeleton organization;GO:0007098 centrosome cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q63ZY7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64017-1", "uniprot_id": [ { "id": "GP176_RAT", "url": "https://www.uniprot.org/uniprot/Q64017", "type": "external" } ], "mass": 56785.0, "length": 513, "protein_name": "Probable G protein-coupled receptor 176", "gene_name": "Gpr176", "organism": "Rat", "refseq_name": "probable G-protein coupled receptor 176", "refseq_ac": [ { "id": "NP_001257915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257915", "type": "external" } ], "gene_names_uniprotkb": "Gpr176; Agr9; Gm1012", "gene_names_refseq": "Gm1012; Gpr176; Gpr; RBU-15", "protein_names_uniprotkb": "Probable G protein-coupled receptor 176; G protein-coupled receptor AGR9; RBU-15", "protein_names_refseq": "G-protein coupled receptor AGR9; probable G-protein coupled receptor 176; putative G protein coupled receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:117257)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7893747;8018717", "class_list": "", "function": "Orphan receptor involved in normal circadian rhythm behavior. Acts through the G protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q63231", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0048512 circadian behavior", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64017-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641X3-1", "uniprot_id": [ { "id": "HEXA_RAT", "url": "https://www.uniprot.org/uniprot/Q641X3", "type": "external" } ], "mass": 60538.0, "length": 528, "protein_name": "Beta-hexosaminidase subunit alpha", "gene_name": "Hexa", "organism": "Rat", "refseq_name": "beta-hexosaminidase subunit alpha precursor", "refseq_ac": [ { "id": "NP_001004443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004443", "type": "external" } ], "gene_names_uniprotkb": "Hexa", "gene_names_refseq": "Hexa", "protein_names_uniprotkb": "Beta-hexosaminidase subunit alpha; 3.2.1.52; Beta-N-acetylhexosaminidase subunit alpha; Hexosaminidase subunit A; N-acetyl-beta-glucosaminidase subunit alpha", "protein_names_refseq": "Hexose aminidase A (alpha polypeptide); N-acetyl-beta-glucosaminidase subunit alpha; beta-N-acetylhexosaminidase subunit alpha; beta-hexosaminidase subunit alpha precursor; beta-hexosaminidase subunit alpha; hexosaminidase A; hexosaminidase subunit A", "tax_id": 10116, "disease": "Tay-Sachs disease (Disease Ontology:DOID:3320)", "pathway": " (rno:300757); (R-RNO-2022857); (R-RNO-2024101); (R-RNO-2160916); (R-RNO-9840310)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosylhydrolase", "function": "Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" } ], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0008375 acetylglucosaminyltransferase activity;GO:0004563 beta-N-acetylhexosaminidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005764 lysosome;GO:0042582 azurophil granule;GO:1905379 beta-N-acetylhexosaminidase complex", "go_biological_process": "GO:0006689 ganglioside catabolic process;GO:0030209 dermatan sulfate proteoglycan catabolic process;GO:0007626 locomotory behavior;GO:0050885 neuromuscular process controlling balance;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q641X3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64259-1", "uniprot_id": [ { "id": "VHL_RAT", "url": "https://www.uniprot.org/uniprot/Q64259", "type": "external" } ], "mass": 21215.0, "length": 185, "protein_name": "von Hippel-Lindau disease tumor suppressor", "gene_name": "Vhl", "organism": "Rat", "refseq_name": "von Hippel-Lindau disease tumor suppressor", "refseq_ac": [ { "id": "NP_434688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_434688", "type": "external" } ], "gene_names_uniprotkb": "Vhl", "gene_names_refseq": "Vhlh; Vhl", "protein_names_uniprotkb": "von Hippel-Lindau disease tumor suppressor; pVHL", "protein_names_refseq": "pVHL; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau protein; von Hippel-Lindau syndrome homolog; von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase", "tax_id": 10116, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); familial erythrocytosis 2 (Disease Ontology:DOID:0060474); Parkinsonism (Disease Ontology:DOID:0080855); retinitis pigmentosa 30 (Disease Ontology:DOID:0110406); retinitis pigmentosa (Disease Ontology:DOID:10584); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); von Hippel-Lindau disease (Disease Ontology:DOID:14175); pancreatic cancer (Disease Ontology:DOID:1793); nephroblastoma (Disease Ontology:DOID:2154); auditory system disease (Disease Ontology:DOID:2742); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); hepatocellular carcinoma (Disease Ontology:DOID:684); polycythemia (Disease Ontology:DOID:8432); retinal degeneration (Disease Ontology:DOID:8466); sudden infant death syndrome (Disease Ontology:DOID:9007); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24874); (R-RNO-1234176); (R-RNO-3232142); (R-RNO-8951664); (R-RNO-9706019); (R-RNO-983168)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "17936701;27324785;29401731;33309718;34531382;7493907;7604013;8599582", "class_list": "", "function": "Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR., [UniProtKB, UniProtKB]; That the change of VHL protein expression was related to neuronal apoptosis after spinal cord injury, [RefSeq, PubMed]; VHL functions to induce neuronal differentiation of neural stem/progenitor cells and skin-derived precursors. Publication Status: Online-Only, [RefSeq, PubMed]; VHL gene methylation contributes to excessive erythrocytosis in chronic mountain sickness rat model by upregulating the HIF-2alpha/EPO pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64197;Q80WY8", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019899 enzyme binding;GO:0003714 transcription corepressor activity;GO:0044877 protein-containing complex binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030891 VCB complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0042069 regulation of catecholamine metabolic process;GO:0048877 homeostasis of number of retina cells;GO:1902072 negative regulation of hypoxia-inducible factor-1alpha signaling pathway;GO:2001233 regulation of apoptotic signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q64259-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q642B2-1", "uniprot_id": [ { "id": "ZN672_RAT", "url": "https://www.uniprot.org/uniprot/Q642B2", "type": "external" } ], "mass": 52164.0, "length": 468, "protein_name": "Zinc finger protein 672", "gene_name": "Znf672", "organism": "Rat", "refseq_name": "zinc finger protein 672", "refseq_ac": [ { "id": "NP_001007670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007670", "type": "external" } ], "gene_names_uniprotkb": "Znf672; Zfp672", "gene_names_refseq": "Zfp672; Znf672", "protein_names_uniprotkb": "Zinc finger protein 672", "protein_names_refseq": "zinc finger protein 672", "tax_id": 10116, "disease": "", "pathway": " (rno:303165)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q642B2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q642G2-1", "uniprot_id": [ { "id": "SOSD1_RAT", "url": "https://www.uniprot.org/uniprot/Q642G2", "type": "external" } ], "mass": 23136.0, "length": 206, "protein_name": "Sclerostin domain-containing protein 1", "gene_name": "Sostdc1", "organism": "Rat", "refseq_name": "sclerostin domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_714959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_714959", "type": "external" } ], "gene_names_uniprotkb": "Sostdc1; Usag1; Wise", "gene_names_refseq": "Sostdc1; Usag-1; Usag1; Wise", "protein_names_uniprotkb": "Sclerostin domain-containing protein 1; USAG-1; Uterine sensitization-associated gene 1 protein; Wnt-signaling modulator", "protein_names_refseq": "context-dependent activator and inhibitor of Wnt signalling protein Wise; sclerostin domain-containing protein 1 precursor; sclerostin domain-containing protein 1; uterine sensitization-associated gene 1 protein; wnt-signaling modulator", "tax_id": 10116, "disease": "", "pathway": " (rno:266803)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12390898;15373764;23184054;26865179;31313025;31391487;38152045", "class_list": "", "function": "Art is able to improve the renal function decline and renal fibrosis induced by UUO, which may be associated with the up-regulation of BMP-7 and down-regulation of USAG-1., [RefSeq, PubMed]; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner (By similarity). May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling., [UniProtKB, PubMed, PubMed]; Downregulation of Sostdc1 in Testicular Sertoli Cells is Prerequisite for Onset of Robust Spermatogenesis at Puberty. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-22-3p facilitates bone marrow mesenchymal stem cell osteogenesis and fracture healing through the SOSTDC1-PI3K/AKT pathway., [RefSeq, PubMed]; MiR-26a promoted fracture healing of rats with nonunion in vivo and osteogenic differentiation of mesenchymal stem cells in vitro, possibly by targeting SOSTDC1., [RefSeq, PubMed]; Rat homologue of the Xenopus-secreted WNT modulator Wise is expressed in the dermal papilla and not in the non-inductive dermal sheath and was additionally expressed at high levels in the precortex and in the putative bulge region [WISE]., [RefSeq, PubMed]; WISE contributes to renal dysfunction by promoting tubular atrophy and interstitial fibrosis., [RefSeq, PubMed]; We report the isolation, cloning, and characterization of a novel gene, uterine sensitization-associated gene-1 (UASG-1), that is preferentially expressed within the maximally sensitized/receptive rat endometrium, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CJA4", "ec_number_list": [], "go_molecular_function": "GO:0098821 BMP receptor activity;GO:0036122 BMP binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060648 mammary gland bud morphogenesis;GO:0010454 negative regulation of cell fate commitment;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0030514 negative regulation of BMP signaling pathway;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q642G2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64335-1", "uniprot_id": [ { "id": "KLRG1_RAT", "url": "https://www.uniprot.org/uniprot/Q64335", "type": "external" } ], "mass": 21356.0, "length": 188, "protein_name": "Killer cell lectin-like receptor subfamily G member 1", "gene_name": "Klrg1", "organism": "Rat", "refseq_name": "killer cell lectin-like receptor subfamily G member 1", "refseq_ac": [ { "id": "NP_113837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113837", "type": "external" } ], "gene_names_uniprotkb": "Klrg1; Mafa", "gene_names_refseq": "Klrg1; MAFA", "protein_names_uniprotkb": "Killer cell lectin-like receptor subfamily G member 1; Mast cell function-associated antigen", "protein_names_refseq": "killer cell lectin-like receptor subfamily G member 1; killer cell lectin-like receptor subfamily G, member 1; mast cell function-associated antigen", "tax_id": 10116, "disease": "", "pathway": " (rno:58975)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12008030;12217400;12217401;16407976;16797115;16934222;17149590;23424659;7568140;9120279", "class_list": "", "function": "(MAFA), selectively regulates the Fc-epsilon-RI stimulus-response coupling network and the subsequent de novo production and secretion of inflammatory mediators. Erratum:[EMBO J. 2019 Feb 1;38(3):e101419. doi: 10.15252/embj.2018101419. PMID: 30709914], [RefSeq, PubMed]; A key role of PPARgamma in regulating pancreatic beta-cell function by improving the stability of Pdx1 and Mafa proteins, [RefSeq, PubMed]; Clustering the mast cell function-associated antigen (MAFA) leads to tyrosine phosphorylation of p62Dok and SHIP and affects RBL-2H3 cell cycle., [RefSeq, PubMed]; Interactions of the mast cell function-associated antigen with the type I Fcepsilon receptor (mast cell function-associated antigen), [RefSeq, PubMed]; Overexpression in the intestine induces intestinal epithelial cells newly to produce and release insulin, [RefSeq, PubMed]; Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Regulates beta-cell-specific gene expression and function., [RefSeq, PubMed]; The functional activities of an inhibitory receptor-the mast cell function-associated antigen [review] (mast cell function-associated antigen) Review article, [RefSeq, PubMed]; This provides additional indication of constitutive interactions between Fc epsilon RI and MAFA., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q64335-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64361-1", "uniprot_id": [ { "id": "LXN_RAT", "url": "https://www.uniprot.org/uniprot/Q64361", "type": "external" } ], "mass": 25580.0, "length": 223, "protein_name": "Latexin", "gene_name": "Lxn", "organism": "Rat", "refseq_name": "latexin", "refseq_ac": [ { "id": "NP_113843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113843", "type": "external" } ], "gene_names_uniprotkb": "Lxn", "gene_names_refseq": "Lxn", "protein_names_uniprotkb": "Latexin; ECI; Endogenous carboxypeptidase inhibitor; TCI; Tissue carboxypeptidase inhibitor", "protein_names_refseq": "ECI; TCI; endogenous carboxypeptidase inhibitor; latexin; tissue carboxypeptidase inhibitor", "tax_id": 10116, "disease": "", "pathway": " (rno:59073)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10350638;21572518;31313823;7524963;8618874", "class_list": "", "function": "Data show that latexin protein expression was reduced after SNI, and the decrease of latexin was associated with an increase of the activity of carboxypeptidase A. Publication Status: Online-Only, [RefSeq, PubMed]; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation (By similarity)., [UniProtKB, PubMed]; Latexin expression correlated with mineralization of articular cartilage during progression of post-traumatic osteoarthritis in a rat model., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0050965 detection of temperature stimulus involved in sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q64361-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64633-1", "uniprot_id": [ { "id": "UD17_RAT", "url": "https://www.uniprot.org/uniprot/Q64633", "type": "external" } ], "mass": 59627.0, "length": 531, "protein_name": "UDP-glucuronosyltransferase 1A7", "gene_name": "Ugt1a7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ugt1a7; Ugt1a7c; Ugt1", "gene_names_refseq": "", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 1A7; 2.4.1.17; A2; UDP-glucuronosyltransferase 1-7; UDP-glucuronosyltransferase 1A7C; UDPGT 1-7; UGT1*7; UGT1-07; UGT1.7; UGT1A7", "protein_names_refseq": "", "tax_id": 10116, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); cholangiocarcinoma (Disease Ontology:DOID:4947); alcoholic pancreatitis (Disease Ontology:DOID:4988); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (R-RNO-156588); (R-RNO-9749641); (R-RNO-9753281)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "2112380;7608130", "class_list": "glycogene;glycosyltransferase", "function": "UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormone epiestradiol. Involved in the glucuronidation of F2-isoprostane (5-epi-5-F2t-IsoP). Involved in the glucuronidation of the phytochemical ferulic acid at the carboxylic acid group. Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan. Also metabolizes mycophenolate, an immunosuppressive agent., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" } ], "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:1904010 response to Aroclor 1254;GO:1904681 response to 3-methylcholanthrene;GO:0006711 estrogen catabolic process;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64633-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64634-1", "uniprot_id": [ { "id": "UD18_RAT", "url": "https://www.uniprot.org/uniprot/Q64634", "type": "external" } ], "mass": 60060.0, "length": 530, "protein_name": "UDP-glucuronosyltransferase 1A8", "gene_name": "Ugt1a8", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ugt1a8; Ugt1", "gene_names_refseq": "", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 1A8; 2.4.1.17; A3; UDP-glucuronosyltransferase 1-8; UDPGT 1-8; UGT1*8; UGT1-08; UGT1.8; UGT1A8", "protein_names_refseq": "", "tax_id": 10116, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); cholangiocarcinoma (Disease Ontology:DOID:4947); alcoholic pancreatitis (Disease Ontology:DOID:4988)", "pathway": " (R-RNO-156588); (R-RNO-9749641); (R-RNO-9753281)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "2112380;7608130", "class_list": "glycogene;glycosyltransferase", "function": "UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens and estrogens. Produces dihydrotestosterone (DHT) diglucuronide from the DHT after two subsequent glucoronidation steps. Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group. Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II. Also metabolizes mycophenolate, an immunosuppressive agent., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" } ], "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0001889 liver development;GO:0016125 sterol metabolic process;GO:0008202 steroid metabolic process;GO:0071385 cellular response to glucocorticoid stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64634-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64637-1", "uniprot_id": [ { "id": "UD13_RAT", "url": "https://www.uniprot.org/uniprot/Q64637", "type": "external" } ], "mass": 60140.0, "length": 531, "protein_name": "UDP-glucuronosyltransferase 1A3", "gene_name": "Ugt1a3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ugt1a3; Ugt1", "gene_names_refseq": "", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 1A3; 2.4.1.17; B3; UDP-glucuronosyltransferase 1-3; UDPGT 1-3; UGT1*3; UGT1-03; UGT1.3; UGT1A3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-156588); (R-RNO-189483); (R-RNO-9749641); (R-RNO-9754706); (R-RNO-9757110)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "2112380;7608130", "class_list": "glycogene;glycosyltransferase", "function": "UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3, essential for the regulation of calcium and phosphate homeostasis. Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonists losartan, candesartan and zolarsartan, which can inhibit the effect of angiotensin II., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" } ], "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0001889 liver development;GO:0016125 sterol metabolic process;GO:0031100 animal organ regeneration;GO:0071385 cellular response to glucocorticoid stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64637-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64666-1", "uniprot_id": [ { "id": "SNAT_RAT", "url": "https://www.uniprot.org/uniprot/Q64666", "type": "external" } ], "mass": 23142.0, "length": 205, "protein_name": "Serotonin N-acetyltransferase", "gene_name": "Aanat", "organism": "Rat", "refseq_name": "serotonin N-acetyltransferase", "refseq_ac": [ { "id": "NP_036950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036950", "type": "external" } ], "gene_names_uniprotkb": "Aanat; Snat", "gene_names_refseq": "AA-NAT; Aanat; Nat4", "protein_names_uniprotkb": "Serotonin N-acetyltransferase; 2.3.1.87; AA-NAT; Aralkylamine N-acetyltransferase; Serotonin acetylase", "protein_names_refseq": "Arylalkylamine N - acetyltransferase (Serotonin N - acetyltransferase); Seretonin N-acetyltransferase; arylakylamine N-acetyltransferase; arylalkylamine N-acetyltransferase; serotonin N-acetyltransferase; serotonin acetylase", "tax_id": 10116, "disease": "advanced sleep phase syndrome (Disease Ontology:DOID:0050628); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25120); (R-RNO-209931)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11427721;15228600;16099857;19103603;20210853;28473754;28502584;30890428;31124080;37256589;39149125;7502081;8524412;8770929", "class_list": "", "function": "Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin., [UniProtKB, UniProtKB]; Effects of acute hypothyroidism on plasma melatonin and Aanat and Asmt expression in the pineal gland and gonads of rats. Publication Status: Online-Only, [RefSeq, PubMed]; Evaluation of hippocampal arylalkylamine N-acetyltransferase activity in amyloid-beta neurotoxicity. Publication Status: Online-Only, [RefSeq, PubMed]; Identified one microRNA, miR-325-3p, as a potential candidate responsible for the down regulation of Aanat after survivors of hypoxic-ischemic brain damage, [RefSeq, PubMed]; Melatonin decreases biliary hyperplasia and liver fibrosis during cholestasis-induced biliary injury via melatonin-dependent autocrine signaling through increased biliary AANAT expression and melatonin secretion, downregulation of miR-200b and specific circadian clock genes., [RefSeq, PubMed]; The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. [provided by RefSeq, Feb 2014]., [RefSeq]; The testes of control animals express the Tph1, Aanat, and Asmt and Per2 genes with 24-h rhythms in mRNA, reaching the maximal values during the dark phase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4JL74;Q64553", "ec_number_list": [ { "id": "2.3.1.87", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.87", "type": "external" } ], "go_molecular_function": "GO:0071889 14-3-3 protein binding;GO:0004060 arylamine N-acetyltransferase activity;GO:0004059 aralkylamine N-acetyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0010043 response to zinc ion;GO:0051592 response to calcium ion;GO:0071320 cellular response to cAMP;GO:0007623 circadian rhythm;GO:0032868 response to insulin", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q64666-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64716-1", "uniprot_id": [ { "id": "INSRR_RAT", "url": "https://www.uniprot.org/uniprot/Q64716", "type": "external" } ], "mass": 144846.0, "length": 1300, "protein_name": "Insulin receptor-related protein", "gene_name": "Insrr", "organism": "Rat", "refseq_name": "insulin receptor-related protein precursor", "refseq_ac": [ { "id": "NP_071548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071548", "type": "external" } ], "gene_names_uniprotkb": "Insrr", "gene_names_refseq": "Insrr; Sirr", "protein_names_uniprotkb": "Insulin receptor-related protein; 2.7.10.1; IR-related receptor; IRR", "protein_names_refseq": "IR-related receptor; IRR; insulin receptor-related protein precursor; insulin receptor-related protein", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162); high grade glioma (Disease Ontology:DOID:3070); glucose metabolism disease (Disease Ontology:DOID:4194); sleep disorder (Disease Ontology:DOID:535); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (rno:60663)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1530648;1603082;20536329;21641549", "class_list": "", "function": "Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB., [UniProtKB, PubMed]; The influence of a stimulatable IRR-tyrosine kinase on major IR/IGF1R signaling pathways and on proliferation and apoptosis of INS-1E beta-cells, [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q63146", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0005009 insulin receptor activity;GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0043560 insulin receptor substrate binding;GO:0043548 phosphatidylinositol 3-kinase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043235 receptor complex;GO:0005899 insulin receptor complex", "go_biological_process": "GO:0071469 cellular response to alkaline pH;GO:0030036 actin cytoskeleton organization;GO:0046777 protein autophosphorylation;GO:0008286 insulin receptor signaling pathway;GO:0030238 male sex determination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q64716-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H45-1", "uniprot_id": [ { "id": "TTC36_RAT", "url": "https://www.uniprot.org/uniprot/Q66H45", "type": "external" } ], "mass": 20151.0, "length": 186, "protein_name": "Tetratricopeptide repeat protein 36", "gene_name": "Ttc36", "organism": "Rat", "refseq_name": "tetratricopeptide repeat protein 36", "refseq_ac": [ { "id": "NP_001005546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005546", "type": "external" } ], "gene_names_uniprotkb": "Ttc36", "gene_names_refseq": "Ttc36", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 36; TPR repeat protein 36", "protein_names_refseq": "TPR repeat protein 36; tetratricopeptide repeat protein 36", "tax_id": 10116, "disease": "", "pathway": " (rno:300676)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007613 memory;GO:0008542 visual learning;GO:0021954 central nervous system neuron development;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0010801 negative regulation of peptidyl-threonine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66H45-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H52-1", "uniprot_id": [ { "id": "IPIL1_RAT", "url": "https://www.uniprot.org/uniprot/Q66H52", "type": "external" } ], "mass": 62548.0, "length": 547, "protein_name": "Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1", "gene_name": "Itpripl1", "organism": "Rat", "refseq_name": "inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 precursor", "refseq_ac": [ { "id": "NP_001020214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020214", "type": "external" } ], "gene_names_uniprotkb": "Itpripl1", "gene_names_refseq": "Itpripl1", "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1", "protein_names_refseq": "inositol 1,4,5-triphosphate receptor-interacting protein-like 1; inositol 1,4,5-trisphosphate receptor interacting protein-like 1; inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:499885)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a ligand of CD3E, inhibiting TCR-CD3 complex signaling to regulate T cell activation. Induces stable CD3E-NCK1 binding, thereby preventing the CD3E-ZAP70 interaction and subsequently inhibiting the activation of the downstream ERK-NFkB signaling cascade and calcium influx., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0042110 T cell activation;GO:0050860 negative regulation of T cell receptor signaling pathway;GO:0070509 calcium ion import;GO:0030217 T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H52-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HA1-1", "uniprot_id": [ { "id": "M3K11_RAT", "url": "https://www.uniprot.org/uniprot/Q66HA1", "type": "external" } ], "mass": 93109.0, "length": 850, "protein_name": "Mitogen-activated protein kinase kinase kinase 11", "gene_name": "Map3k11", "organism": "Rat", "refseq_name": "mitogen-activated protein kinase kinase kinase 11", "refseq_ac": [ { "id": "NP_001013168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013168", "type": "external" } ], "gene_names_uniprotkb": "Map3k11; Mlk3", "gene_names_refseq": "Map3k11; Mlk-3; Mlk3; RHOE", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 11; 2.7.11.25; Mixed lineage kinase 3", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase 11; mixed lineage kinase 3", "tax_id": 10116, "disease": "", "pathway": " (rno:309168); (R-RNO-5673000); (R-RNO-9013408); (R-RNO-9013424)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "14575811;14690535;21726169;22123824;22673903;27280801;29864954", "class_list": "", "function": "Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle (By similarity)., [UniProtKB]; Data suggest that K252a induced neuroprotection against ischemia/reperfusion in rat hippocampal CA1 subregion via inhibiting the mitochondrial Bax apoptosis pathway induced by JNK/MLK3 activation., [RefSeq, PubMed]; Data suggest that the up-regulation of miR-199b-5p enhances proliferation of beta-cells at least in part through down-regulation of Mixed lineage kinase-3., [RefSeq, PubMed]; MiR-140-5p aggravated hypoxia-induced cell injury partially through up-regulation of MLK3., [RefSeq, PubMed]; The activation of MLK3 during the early stages of ischemia/reperfusion is modulated by S-nitrosylation and provides a potential new approach for stroke therapy whereby the post-translational modification machinery is targeted., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80YF1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0031434 mitogen-activated protein kinase kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0034451 centriolar satellite", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0043065 positive regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0000165 MAPK cascade;GO:0007254 JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q66HA1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HG9-1", "uniprot_id": [ { "id": "MAVS_RAT", "url": "https://www.uniprot.org/uniprot/Q66HG9", "type": "external" } ], "mass": 53805.0, "length": 507, "protein_name": "Mitochondrial antiviral-signaling protein", "gene_name": "Mavs", "organism": "Rat", "refseq_name": "mitochondrial antiviral-signaling protein", "refseq_ac": [ { "id": "NP_001005556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005556", "type": "external" } ], "gene_names_uniprotkb": "Mavs; Ips1; Visa", "gene_names_refseq": "Mavs; Visa", "protein_names_uniprotkb": "Mitochondrial antiviral-signaling protein; IPS-1; Interferon beta promoter stimulator protein 1; MAVS; VISA; Virus-induced-signaling adapter", "protein_names_refseq": "IPS-1; interferon beta promoter stimulator protein 1; mitochondrial antiviral-signaling protein; virus-induced signaling adaptor; virus-induced-signaling adapter", "tax_id": 10116, "disease": "", "pathway": " (rno:311430); (R-RNO-168928); (R-RNO-936440); (R-RNO-9833482)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "18683930;22673903;29393594;34502162", "class_list": "", "function": "Adapter required for innate immune defense against viruses. Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0071360 cellular response to exogenous dsRNA;GO:0032727 positive regulation of interferon-alpha production;GO:0060760 positive regulation of response to cytokine stimulus;GO:0070585 protein localization to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q66HG9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HH4-1", "uniprot_id": [ { "id": "HERP2_RAT", "url": "https://www.uniprot.org/uniprot/Q66HH4", "type": "external" } ], "mass": 44151.0, "length": 401, "protein_name": "Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein", "gene_name": "Herpud2", "organism": "Rat", "refseq_name": "homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein", "refseq_ac": [ { "id": "NP_001020159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020159", "type": "external" } ], "gene_names_uniprotkb": "Herpud2", "gene_names_refseq": "Herpud2; RGD1307343", "protein_names_uniprotkb": "Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein", "protein_names_refseq": "homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:300463)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Could be involved in the unfolded protein response (UPR) pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HH4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FQ0-1", "uniprot_id": [ { "id": "TCPE_RAT", "url": "https://www.uniprot.org/uniprot/Q68FQ0", "type": "external" } ], "mass": 59537.0, "length": 541, "protein_name": "T-complex protein 1 subunit epsilon", "gene_name": "Cct5", "organism": "Rat", "refseq_name": "T-complex protein 1 subunit epsilon", "refseq_ac": [ { "id": "NP_001004078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004078", "type": "external" } ], "gene_names_uniprotkb": "Cct5", "gene_names_refseq": "Cct5", "protein_names_uniprotkb": "T-complex protein 1 subunit epsilon; 3.6.1.-; CCT-epsilon; TCP-1-epsilon", "protein_names_refseq": "CCT-epsilon; T-complex protein 1 subunit epsilon; TCP-1-epsilon; chaperonin containing Tcp1, subunit 5 (epsilon); chaperonin subunit 5 (epsilon)", "tax_id": 10116, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); autosomal recessive sensory neuropathy with spastic paraplegia (Disease Ontology:DOID:0061188); Bardet-Biedl syndrome 10 (Disease Ontology:DOID:0110132); sensory peripheral neuropathy (Disease Ontology:DOID:2491)", "pathway": " (rno:294864); (R-RNO-390471); (R-RNO-5620922); (R-RNO-6814122)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "18047804", "class_list": "", "function": "Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PCT4", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005874 microtubule;GO:0044297 cell body;GO:0005832 chaperonin-containing T-complex", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0009615 response to virus;GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0050821 protein stabilization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q68FQ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FT9-1", "uniprot_id": [ { "id": "SCLY_RAT", "url": "https://www.uniprot.org/uniprot/Q68FT9", "type": "external" } ], "mass": 47256.0, "length": 432, "protein_name": "Selenocysteine lyase", "gene_name": "Scly", "organism": "Rat", "refseq_name": "selenocysteine lyase", "refseq_ac": [ { "id": "NP_001007756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007756", "type": "external" } ], "gene_names_uniprotkb": "Scly", "gene_names_refseq": "Scly", "protein_names_uniprotkb": "Selenocysteine lyase; 4.4.1.16", "protein_names_refseq": "selenocysteine lyase", "tax_id": 10116, "disease": "", "pathway": " (rno:363285); (R-RNO-2408508)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16874457;20164179", "class_list": "", "function": "An enhancer element between bp -152 and -298 of the SCL 5'-regulatory region was identified, with protein binding to an AP-1 binding site that may be involved in the regulation of SCL-RNA in vivo in an endogenous feedback mechanism., [RefSeq, PubMed]; Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; ESI-MS analysis of wild-type and C375A mutant SCL revealed that the catalytic reaction proceeds via the formation of an enzyme-bound selenopersulfide intermediate on the catalytically essential Cys-375 residue., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.4.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.16", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0016597 amino acid binding;GO:0016740 transferase activity;GO:0009000 selenocysteine lyase activity;GO:0070279 vitamin B6 binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:1902494 catalytic complex", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0032868 response to insulin;GO:0016261 selenocysteine catabolic process;GO:1900408 negative regulation of cellular response to oxidative stress;GO:0001887 selenium compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q68FT9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FU4-1", "uniprot_id": [ { "id": "SUCHY_RAT", "url": "https://www.uniprot.org/uniprot/Q68FU4", "type": "external" } ], "mass": 47549.0, "length": 436, "protein_name": "Succinyl-CoA:glutarate CoA-transferase", "gene_name": "Sugct", "organism": "Rat", "refseq_name": "succinyl-CoA:glutarate CoA-transferase", "refseq_ac": [ { "id": "NP_001014168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014168", "type": "external" } ], "gene_names_uniprotkb": "Sugct", "gene_names_refseq": "RGD1308114; Sugct", "protein_names_uniprotkb": "Succinyl-CoA:glutarate CoA-transferase; 2.8.3.-; 2.8.3.13; Dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase SUGCT; Succinate--hydroxymethylglutarate CoA-transferase", "protein_names_refseq": "caiB/baiF CoA-transferase family protein C7orf10 homolog; dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase SUGCT; succinate--hydroxymethylglutarate CoA-transferase; succinyl-CoA:glutarate CoA-transferase", "tax_id": 10116, "disease": "glutaric acidemia type 3 (Disease Ontology:DOID:0112246)", "pathway": " (rno:361253)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Coenzyme A (CoA) transferase that reversibly catalyzes the transfer of a CoA moiety from a dicarboxyl-CoA to a dicarboxylate in a metabolite recycling process. Displays preference for succinyl-CoA and glutarate-CoA as dicarboxyl-CoA donors and glutarate, succinate, adipate/hexanedioate, itaconate and 3-hydroxy-3-methylglutarate as dicarboxylate acceptors (By similarity). Acts on intermediates or end products of lysine and tryptophan degradation pathway, in particular catalyzes succinyl-CoA-dependent reesterification of free glutarate into glutaryl-CoA to prevent renal excretion of glutarate (By similarity). Upon inflammation, may convert macrophage-derived itaconate to itaconyl-CoA in erythroid precursors where it negatively regulates the TCA cycle and heme synthesis to limit erythroid differentiation in the context of stress erythropoiesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LXJ6", "ec_number_list": [ { "id": "2.8.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.13", "type": "external" }, { "id": "2.8.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.-", "type": "external" } ], "go_molecular_function": "GO:0047369 succinate-hydroxymethylglutarate CoA-transferase activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68FU4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FX5-1", "uniprot_id": [ { "id": "SNPC2_RAT", "url": "https://www.uniprot.org/uniprot/Q68FX5", "type": "external" } ], "mass": 38569.0, "length": 359, "protein_name": "snRNA-activating protein complex subunit 2", "gene_name": "Snapc2", "organism": "Rat", "refseq_name": "snRNA-activating protein complex subunit 2 isoform 1", "refseq_ac": [ { "id": "NP_001013139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013139", "type": "external" } ], "gene_names_uniprotkb": "Snapc2", "gene_names_refseq": "Snapc2", "protein_names_uniprotkb": "snRNA-activating protein complex subunit 2; SNAPc 45 kDa subunit; SNAPc subunit 2; Small nuclear RNA-activating complex polypeptide 2; snRNA-activating protein complex 45 kDa subunit", "protein_names_refseq": "SNAPc 45 kDa subunit; SNAPc subunit 2; snRNA-activating protein complex 45 kDa subunit; snRNA-activating protein complex subunit 2 isoform 1; snRNA-activating protein complex subunit 2", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-6807505); (R-RNO-76071)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0019185 snRNA-activating protein complex", "go_biological_process": "GO:0009301 snRNA transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FX5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FX7-1", "uniprot_id": [ { "id": "THOC5_RAT", "url": "https://www.uniprot.org/uniprot/Q68FX7", "type": "external" } ], "mass": 78660.0, "length": 682, "protein_name": "THO complex subunit 5 homolog", "gene_name": "Thoc5", "organism": "Rat", "refseq_name": "THO complex subunit 5 homolog isoform 1", "refseq_ac": [ { "id": "NP_001012153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012153", "type": "external" } ], "gene_names_uniprotkb": "Thoc5; Fmip", "gene_names_refseq": "Fmip; Thoc5", "protein_names_uniprotkb": "THO complex subunit 5 homolog; Fms-interacting protein", "protein_names_refseq": "Fms interacting protein; THO complex 5; THO complex subunit 5 homolog isoform 1; THO complex subunit 5 homolog; fms-interacting protein", "tax_id": 10116, "disease": "breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (rno:360972); (R-RNO-159236)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes., [UniProtKB, UniProtKB]; Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0000347 THO complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000445 THO complex part of transcription export complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0000902 cell morphogenesis;GO:0008380 RNA splicing;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FX7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FX9-1", "uniprot_id": [ { "id": "SIR5_RAT", "url": "https://www.uniprot.org/uniprot/Q68FX9", "type": "external" } ], "mass": 34098.0, "length": 310, "protein_name": "NAD-dependent protein deacylase sirtuin-5, mitochondrial", "gene_name": "Sirt5", "organism": "Rat", "refseq_name": "NAD-dependent protein deacylase sirtuin-5, mitochondrial", "refseq_ac": [ { "id": "NP_001004256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004256", "type": "external" } ], "gene_names_uniprotkb": "Sirt5", "gene_names_refseq": "Sirt5", "protein_names_uniprotkb": "NAD-dependent protein deacylase sirtuin-5, mitochondrial; 2.3.1.-; Regulatory protein SIR2 homolog 5; SIR2-like protein 5", "protein_names_refseq": "NAD-dependent deacetylase sirtuin-5; NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial; NAD-dependent protein deacylase sirtuin-5, mitochondrial; SIR2-like protein 5; regulatory protein SIR2 homolog 5", "tax_id": 10116, "disease": "", "pathway": " (rno:306840); (R-RNO-2151201); (R-RNO-70635)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "18555008;30098330;32099074;33191606;36653443;38170384;38843836", "class_list": "", "function": "Alcohol decreases mitochondrial SIRT5 level., [RefSeq, PubMed]; Both diabetic rats and mice demonstrated significantly weakened SIRT5 expression in the pancreas, compared to wild-type animals, implying a possible correlation between SIRT5 and pancreatic beta cell function., [RefSeq, PubMed]; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX., [UniProtKB, HAMAP]; SIRT5 Regulates Ferroptosis through the Nrf2/HO-1 Signaling Axis to Participate in Ischemia-Reperfusion Injury in Ischemic Stroke., [RefSeq, PubMed]; SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis., [RefSeq, PubMed]; Sirtuin 5 deficiency increases disease severity in rats with adjuvant-induced arthritis., [RefSeq, PubMed]; The possible role of sirtuin 5 in the pathogenesis of apical periodontitis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "6.3.4.16", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.16", "type": "external" } ], "go_molecular_function": "GO:0036054 protein-malonyllysine demalonylase activity;GO:0036055 protein-succinyllysine desuccinylase activity;GO:0061697 protein-glutaryllysine deglutarylase activity;GO:0008270 zinc ion binding;GO:0070403 NAD+ binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0010566 regulation of ketone biosynthetic process;GO:0036046 protein demalonylation;GO:0036047 peptidyl-lysine demalonylation;GO:0036048 protein desuccinylation;GO:0036049 peptidyl-lysine desuccinylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q68FX9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68G38-1", "uniprot_id": [ { "id": "TOR1A_RAT", "url": "https://www.uniprot.org/uniprot/Q68G38", "type": "external" } ], "mass": 37949.0, "length": 333, "protein_name": "Torsin-1A", "gene_name": "Tor1a", "organism": "Rat", "refseq_name": "torsin-1A precursor", "refseq_ac": [ { "id": "NP_695215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_695215", "type": "external" } ], "gene_names_uniprotkb": "Tor1a; Dyt1", "gene_names_refseq": "Dyt1; Tor1a", "protein_names_uniprotkb": "Torsin-1A; 3.6.4.-; Dystonia 1 protein; Torsin ATPase 1", "protein_names_refseq": "dystonia 1 protein; dystonia 1, torsion (autosomal dominant; torsin A); torsin ATPase 1; torsin A; torsin-1A precursor; torsin-1A", "tax_id": 10116, "disease": "focal dystonia (Disease Ontology:DOID:0050836); torsion dystonia 1 (Disease Ontology:DOID:0060730); arthrogryposis multiplex congenita-5 (Disease Ontology:DOID:0080981); Parkinson's disease (Disease Ontology:DOID:14330); dystonia (Disease Ontology:DOID:543)", "pathway": " (rno:266606); (R-RNO-8856825)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12007841;12671990;14970196;18167355;21102408;22472189;29289717;29393594", "class_list": "", "function": "Developed transgenic rat models for DYT1 dystonia harboring the full length human mutant and wildtype Tor1A gene., [RefSeq, PubMed]; Mutant torsinA may interfere with and/or compromise ER functions, especially in dopaminergic neurons, which have high levels of torsinA and are intrinsically vulnerable to oxidative stress., [RefSeq, PubMed]; Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues (By similarity)., [UniProtKB, UniProtKB]; TorsinA was post-transcriptionally upregulated upon acute ER stress, suggesting a role in this response. Increased basal phosphorylation of eIF2alpha in DYT1 transgenic rats was associated with abnormal response to acute ER stress. Unbiased RNA-Seq-based transcriptomic analysis of embryonic brain tissue in heterozygous and homozygous DYT1 knockin mice confirmed presence of eIF2alpha dysregulation in the DYT1 brain., [RefSeq, PubMed]; Wild-type torsinA undergoes anterograde transport along microtubules mediated by kinesin and may act as a molecular chaperone regulating kinesin activity and/or cargo binding, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3L8", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0008092 cytoskeletal protein binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0051584 regulation of dopamine uptake involved in synaptic transmission;GO:1900244 positive regulation of synaptic vesicle endocytosis;GO:0006979 response to oxidative stress;GO:0007155 cell adhesion;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q68G38-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69FB3-1", "uniprot_id": [ { "id": "JPH4_RAT", "url": "https://www.uniprot.org/uniprot/Q69FB3", "type": "external" } ], "mass": 66441.0, "length": 630, "protein_name": "Junctophilin-4", "gene_name": "Jph4", "organism": "Rat", "refseq_name": "junctophilin-4", "refseq_ac": [ { "id": "NP_001003711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003711", "type": "external" } ], "gene_names_uniprotkb": "Jph4; Ap1g2; Jphl1", "gene_names_refseq": "Jph4", "protein_names_uniprotkb": "Junctophilin-4; JP-4; Junctophilin-like 1 protein", "protein_names_refseq": "JP-4; junctophilin-4; junctophilin-like 1 protein", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700)", "pathway": " (rno:445271)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005790 smooth endoplasmic reticulum;GO:0005886 plasma membrane;GO:0043198 dendritic shaft;GO:0005789 endoplasmic reticulum membrane;GO:0030314 junctional membrane complex", "go_biological_process": "GO:0007612 learning;GO:0050885 neuromuscular process controlling balance;GO:0048167 regulation of synaptic plasticity;GO:0001817 regulation of cytokine production;GO:2001256 regulation of store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q69FB3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXN6-1", "uniprot_id": [ { "id": "SKAP_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXN6", "type": "external" } ], "mass": 34885.0, "length": 312, "protein_name": "Small kinetochore-associated protein", "gene_name": "Knstrn", "organism": "Rat", "refseq_name": "small kinetochore-associated protein", "refseq_ac": [ { "id": "NP_001004264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004264", "type": "external" } ], "gene_names_uniprotkb": "Knstrn; Skap; Traf4af1", "gene_names_refseq": "C15orf23; Knstrn; SKAP; Traf4af1", "protein_names_uniprotkb": "Small kinetochore-associated protein; Kinastrin; Kinetochore-localized astrin-binding protein; Kinetochore-localized astrin/SPAG5-binding protein; SKAP; TRAF4-associated factor 1", "protein_names_refseq": "kinastrin; kinetochore-localized astrin-binding protein; putative TRAF4-associated factor 1; small kinetochore-associated protein", "tax_id": 10116, "disease": "skin squamous cell carcinoma (Disease Ontology:DOID:3151); actinic keratosis (Disease Ontology:DOID:8866)", "pathway": " (rno:311325)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "28351621", "class_list": "", "function": "Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division., [UniProtKB, UniProtKB]; These results indicate that Astrin is required for normal mitotic progression in immature Sertoli cells and that the most severe type of testicullar dysplasia in hgn/hgn rats is caused by mitotic cell death of immature Sertoli cells due to lack of Astrin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051010 microtubule plus-end binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005815 microtubule organizing center;GO:0000776 kinetochore;GO:0001726 ruffle", "go_biological_process": "GO:0007059 chromosome segregation;GO:0016477 cell migration;GO:0051301 cell division;GO:0051988 regulation of attachment of spindle microtubules to kinetochore;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXN6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXQ0-1", "uniprot_id": [ { "id": "SAE1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXQ0", "type": "external" } ], "mass": 38513.0, "length": 349, "protein_name": "SUMO-activating enzyme subunit 1", "gene_name": "Sae1", "organism": "Rat", "refseq_name": "SUMO-activating enzyme subunit 1", "refseq_ac": [ { "id": "NP_001012063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012063", "type": "external" } ], "gene_names_uniprotkb": "Sae1; Uble1a", "gene_names_refseq": "Sae1; Uble1a", "protein_names_uniprotkb": "SUMO-activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A", "protein_names_refseq": "SUMO-activating enzyme subunit 1; ubiquitin-like 1 (sentrin) activating enzyme E1A; ubiquitin-like 1-activating enzyme E1A", "tax_id": 10116, "disease": "hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (rno:308384); (R-RNO-3065676); (R-RNO-3065678)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019948 SUMO activating enzyme activity;GO:0046982 protein heterodimerization activity;GO:0043008 ATP-dependent protein binding;GO:0044388 small protein activating enzyme binding;GO:0008641 ubiquitin-like modifier activating enzyme activity", "go_cellular_component": "GO:0031510 SUMO activating enzyme complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016925 protein sumoylation;GO:0033235 positive regulation of protein sumoylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXQ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2A6-1", "uniprot_id": [ { "id": "MK15_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2A6", "type": "external" } ], "mass": 60724.0, "length": 547, "protein_name": "Mitogen-activated protein kinase 15", "gene_name": "Mapk15", "organism": "Rat", "refseq_name": "mitogen-activated protein kinase 15", "refseq_ac": [ { "id": "NP_775453", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775453", "type": "external" } ], "gene_names_uniprotkb": "Mapk15; Erk7; Erk8", "gene_names_refseq": "ERK-8; Erk7; Mapk15", "protein_names_uniprotkb": "Mitogen-activated protein kinase 15; 2.7.11.24; ERK-7; ERK-8; Extracellular signal-regulated kinase 7; Extracellular signal-regulated kinase 8; MAP kinase 15; MAPK 15", "protein_names_refseq": "ERK-7; MAP kinase 15; MAPK 15; extracellular signal-regulated kinase 7; extracellular signal-regulated kinase 8; mitogen-activated protein kinase 15", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (rno:286997)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11287416;11875070;15033983;9880541;9891064", "class_list": "", "function": "Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner. Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation. Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling. Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins. Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion. Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA. Regulates DA transporter (DAT) activity and protein expression via activation of RhoA. In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (By similarity). Also functions in a kinase activity-independent manner as a negative regulator of growth (PubMed:9891064). Phosphorylates in vitro FOS and MBP (PubMed:11875070). During oocyte maturation, plays a key role in the microtubule organization and mei- otic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:1905832 positive regulation of spindle assembly;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z2A6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P719-1", "uniprot_id": [ { "id": "MMGT2_RAT", "url": "https://www.uniprot.org/uniprot/Q6P719", "type": "external" } ], "mass": 13796.0, "length": 124, "protein_name": "Membrane magnesium transporter 2", "gene_name": "Mmgt2", "organism": "Rat", "refseq_name": "membrane magnesium transporter 2", "refseq_ac": [ { "id": "NP_001013989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013989", "type": "external" } ], "gene_names_uniprotkb": "Mmgt2", "gene_names_refseq": "Mmgt2; RGD1311260", "protein_names_uniprotkb": "Membrane magnesium transporter 2", "protein_names_refseq": "membrane magnesium transporter 2", "tax_id": 10116, "disease": "", "pathway": " (rno:303211)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates Mg(2+) transport., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0072546 EMC complex;GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0015693 magnesium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P719-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P4Z6-1", "uniprot_id": [ { "id": "LCMT1_RAT", "url": "https://www.uniprot.org/uniprot/Q6P4Z6", "type": "external" } ], "mass": 38330.0, "length": 332, "protein_name": "Leucine carboxyl methyltransferase 1", "gene_name": "Lcmt1", "organism": "Rat", "refseq_name": "leucine carboxyl methyltransferase 1", "refseq_ac": [ { "id": "NP_955437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955437", "type": "external" } ], "gene_names_uniprotkb": "Lcmt1", "gene_names_refseq": "Lcmt1", "protein_names_uniprotkb": "Leucine carboxyl methyltransferase 1; 2.1.1.233; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1", "protein_names_refseq": "[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1; leucine carboxyl methyltransferase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361643); (R-RNO-69273)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21292165;36555780", "class_list": "", "function": "A dominant-negative LCMT-1 mutant attenuates the cell cycle without causing cell death, likely by inhibiting uncontrolled phosphatase activity, [RefSeq, PubMed]; HIF-1alpha Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia. Publication Status: Online-Only, [RefSeq, PubMed]; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.1.1.233", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.233", "type": "external" } ], "go_molecular_function": "GO:0008276 protein methyltransferase activity;GO:0003880 protein C-terminal carboxyl O-methyltransferase activity;GO:0018423 protein C-terminal leucine carboxyl O-methyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0010906 regulation of glucose metabolic process;GO:0031333 negative regulation of protein-containing complex assembly;GO:0042981 regulation of apoptotic process;GO:0006479 protein methylation;GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P4Z6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPH2-1", "uniprot_id": [ { "id": "MRP_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPH2", "type": "external" } ], "mass": 19847.0, "length": 199, "protein_name": "MARCKS-related protein", "gene_name": "Marcksl1", "organism": "Rat", "refseq_name": "MARCKS-related protein", "refseq_ac": [ { "id": "NP_110489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110489", "type": "external" } ], "gene_names_uniprotkb": "Marcksl1; Mlp", "gene_names_refseq": "F52; Marcksl1; Mlp", "protein_names_uniprotkb": "MARCKS-related protein; Brain protein F52; MARCKS-like protein 1; Mac-MARCKS; MacMARCKS; Macrophage myristoylated alanine-rich C kinase substrate", "protein_names_refseq": "MARCKS-like protein 1; MARCKS-related protein-like; MARCKS-related protein; brain protein F52; mac-MARCKS; macMARCKS; macrophage myristoylated alanine-rich C kinase substrate", "tax_id": 10116, "disease": "", "pathway": " (rno:81520)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11882609;22751924", "class_list": "", "function": "C-Jun N-terminal kinase phosphorylation of MARCKSL1 enables it to bundle and stabilize F-actin, increase filopodium numbers and dynamics, and retard migration in neurons., [RefSeq, PubMed]; Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems., [UniProtKB, UniProtKB, UniProtKB]; PKCbeta-MARCKS signaling may be a general mechanism for the stimulation of vesicular trafficking in brain neurons., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0008284 positive regulation of cell population proliferation;GO:0007417 central nervous system development;GO:0099509 regulation of presynaptic cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9EPH2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV57-1", "uniprot_id": [ { "id": "MPEG1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WV57", "type": "external" } ], "mass": 78527.0, "length": 714, "protein_name": "Macrophage-expressed gene 1 protein", "gene_name": "Mpeg1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mpeg1", "gene_names_refseq": "", "protein_names_uniprotkb": "Macrophage-expressed gene 1 protein; Macrophage gene 1 protein; Mpg-1; P-2; Perforin-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "primary immunodeficiency disease (Disease Ontology:DOID:612)", "pathway": " (rno:64552)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Pore-forming protein involved in both innate and adaptive immunity. Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation. Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Pore-forming protein that plays a central role in antigen cross-presentation in dendritic cells by mediating delivery of antigens for cross-presentation. Dendritic cells bridge innate and adaptive immunity by capturing exogenous antigens on MHC class-I molecules and presenting them to naive CD8(+) T-cells. Acts by forming a pore in antigen-containing compartments, promoting the release of antigens into the cytosol, enabling generation of MHCI:peptide complexes and T-cell priming., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022829 wide pore channel activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0031410 cytoplasmic vesicle;GO:0030670 phagocytic vesicle membrane;GO:0045335 phagocytic vesicle;GO:0061474 phagolysosome membrane;GO:0036019 endolysosome", "go_biological_process": "GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0002468 dendritic cell antigen processing and presentation;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9WV57-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TN39-1", "uniprot_id": [ { "id": "MRGRG_RAT", "url": "https://www.uniprot.org/uniprot/Q7TN39", "type": "external" } ], "mass": 32212.0, "length": 289, "protein_name": "Mas-related G protein-coupled receptor member G", "gene_name": "Mrgprg", "organism": "Rat", "refseq_name": "mas-related G-protein coupled receptor member G", "refseq_ac": [ { "id": "NP_982296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_982296", "type": "external" } ], "gene_names_uniprotkb": "Mrgprg; Mrgg", "gene_names_refseq": "Mrgg; Mrgprg", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member G", "protein_names_refseq": "G protein-coupled receptor Mrgg; MAS-related G-protein coupled receptor, member G; MAS-related GPR, member G; MAS-related gene G; mas-related G-protein coupled receptor member G", "tax_id": 10116, "disease": "", "pathway": " (rno:309133)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12909716", "class_list": "", "function": "Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TN39-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3P4-1", "uniprot_id": [ { "id": "MSI1H_RAT", "url": "https://www.uniprot.org/uniprot/Q8K3P4", "type": "external" } ], "mass": 39134.0, "length": 362, "protein_name": "RNA-binding protein Musashi homolog 1", "gene_name": "Msi1", "organism": "Rat", "refseq_name": "RNA-binding protein Musashi homolog 1", "refseq_ac": [ { "id": "NP_683688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_683688", "type": "external" } ], "gene_names_uniprotkb": "Msi1; Msi1h", "gene_names_refseq": "Msi1h; Msi1", "protein_names_uniprotkb": "RNA-binding protein Musashi homolog 1; Musashi-1", "protein_names_refseq": "Musashi homolog 1(Drosophila); RNA-binding protein Musashi homolog 1; musashi-1", "tax_id": 10116, "disease": "autosomal dominant limb-girdle muscular dystrophy type 3 (Disease Ontology:DOID:0110306); brain ischemia (Disease Ontology:DOID:2316); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (rno:259272)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12205668;16554442;25888190;33810326;33843023", "class_list": "", "function": "Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone., [RefSeq, PubMed]; Data suggest that in response to environmental cues that oppose cell cycle progression, regulation of Musashi function is required to promote target mRNA translation and cell fate transition Publication Status: Online-Only, [RefSeq, PubMed]; Expression of Musashi-1 Increases in Bone Healing. Publication Status: Online-Only, [RefSeq, PubMed]; Neuronal progenitor cells in the SGZ expressed Msi1 but not nestin., [RefSeq, PubMed]; RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0003727 single-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006417 regulation of translation;GO:0030855 epithelial cell differentiation;GO:0007417 central nervous system development;GO:0009725 response to hormone", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K3P4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY40-1", "uniprot_id": [ { "id": "JMJD8_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY40", "type": "external" } ], "mass": 30507.0, "length": 269, "protein_name": "JmjC domain-containing protein 8", "gene_name": "Jmjd8", "organism": "Rat", "refseq_name": "jmjC domain-containing protein 8 precursor", "refseq_ac": [ { "id": "NP_001014138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014138", "type": "external" } ], "gene_names_uniprotkb": "Jmjd8", "gene_names_refseq": "Jmjd8; RGD1307381", "protein_names_uniprotkb": "JmjC domain-containing protein 8; Jumonji domain-containing protein 8", "protein_names_refseq": "jmjC domain-containing protein 8 precursor; jmjC domain-containing protein 8; jumonji domain-containing protein 8", "tax_id": 10116, "disease": "", "pathway": " (rno:360498)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a positive regulator of TNF-induced NF-kappaB signaling. Regulates angiogenesis and cellular metabolism through interaction with PKM., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0006110 regulation of glycolytic process;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0002040 sprouting angiogenesis;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY40-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TN45-1", "uniprot_id": [ { "id": "MRGB4_RAT", "url": "https://www.uniprot.org/uniprot/Q7TN45", "type": "external" } ], "mass": 36787.0, "length": 323, "protein_name": "Mas-related G protein-coupled receptor member B4", "gene_name": "Mrgprb4", "organism": "Rat", "refseq_name": "mas-related G-protein coupled receptor member B4", "refseq_ac": [ { "id": "NP_001002287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002287", "type": "external" } ], "gene_names_uniprotkb": "Mrgprb4; Mrgb4", "gene_names_refseq": "MrgB4; Mrgprb4", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member B4", "protein_names_refseq": "MAS-related G protein-coupled receptor, member B4; MAS-related gene B4; mas-related G-protein coupled receptor member B4", "tax_id": 10116, "disease": "", "pathway": " (rno:404658)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12909716", "class_list": "", "function": "Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TN45-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZ48-1", "uniprot_id": [ { "id": "ZBT7A_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZ48", "type": "external" } ], "mass": 60543.0, "length": 569, "protein_name": "Zinc finger and BTB domain-containing protein 7A", "gene_name": "Zbtb7a", "organism": "Rat", "refseq_name": "zinc finger and BTB domain-containing protein 7A", "refseq_ac": [ { "id": "NP_446454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446454", "type": "external" } ], "gene_names_uniprotkb": "Zbtb7a; Lrf; Oczf; Zbtb7", "gene_names_refseq": "Lrf; OCZF; Zbtb7a; Zbtb7", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 7A; Leukemia/lymphoma-related factor; Osteoclast-derived zinc finger protein", "protein_names_refseq": "leukemia/lymphoma-related factor; osteoclast-derived zinc finger protein; zinc finger and BTB domain-containing protein 7A", "tax_id": 10116, "disease": "", "pathway": " (rno:117107)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10477728;15337766;22673903;35474350", "class_list": "", "function": "LRF is the first transcription factor found to bind directly to the COMP gene promoter, to recruit HDAC1, and to regulate both COMP gene expression and chondrogenic differentiation, [RefSeq, PubMed]; Leukemia/lymphoma-related factor (LRF) or osteoclast zinc finger protein (OCZF) overexpression promotes osteoclast survival by increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by the RNA binding protein SAM68., [RefSeq, PubMed]; Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (By similarity) (PubMed:10477728). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (By similarity) (PubMed:10477728). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms. That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (By similarity). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA. Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes. Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Involved in the switch between fetal and adult globin expression during erythroid cells maturation. Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (By similarity). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation. Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis. Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (By similarity). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages. Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity). Also regulates osteoclast differentiation (PubMed:10477728). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ. Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0035861 site of double-strand break;GO:0070418 DNA-dependent protein kinase complex", "go_biological_process": "GO:0097680 double-strand break repair via classical nonhomologous end joining;GO:2000677 regulation of transcription regulatory region DNA binding;GO:0043249 erythrocyte maturation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006110 regulation of glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QZ48-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYV1-1", "uniprot_id": [ { "id": "TEFF1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYV1", "type": "external" } ], "mass": 40143.0, "length": 373, "protein_name": "Tomoregulin-1", "gene_name": "Tmeff1", "organism": "Rat", "refseq_name": "tomoregulin-1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_075409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075409", "type": "external" } ], "gene_names_uniprotkb": "Tmeff1; Nc1", "gene_names_refseq": "Tmeff1", "protein_names_uniprotkb": "Tomoregulin-1; Protein NC1; TR-1; Transmembrane protein with EGF-like and one follistatin-like domain", "protein_names_refseq": "TR-1; tomoregulin-1 isoform 1 precursor; tomoregulin-1; transmembrane protein with EGF-like and one follistatin-like domain", "tax_id": 10116, "disease": "", "pathway": " (rno:63845)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Neuron-specific restriction factor that prevents herpes simplex virus 1 (HHV-1) infection in the brain by blocking viral entry. Also able to restrict herpes simplex virus 2 (HHV-2) infection, although to a lesser extent. Acts by preventing the association between the viral glycoprotein D (gD) and its cell surface receptor NECTIN1, thereby inhibiting fusion of the virus and the cell membrane. Also able to prevent the association between the viral glycoprotein B (gB) and MYH9/NMMHC-IIA and MYH10/NMMHC-IIB receptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0141069 receptor ligand inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0046597 host-mediated suppression of symbiont invasion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9QYV1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY87-1", "uniprot_id": [ { "id": "THOC6_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY87", "type": "external" } ], "mass": 37423.0, "length": 341, "protein_name": "THO complex subunit 6 homolog", "gene_name": "Thoc6", "organism": "Rat", "refseq_name": "THO complex subunit 6 homolog", "refseq_ac": [ { "id": "NP_077360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077360", "type": "external" } ], "gene_names_uniprotkb": "Thoc6; Pdrp; wdr58", "gene_names_refseq": "Pdrp; Thoc6", "protein_names_uniprotkb": "THO complex subunit 6 homolog; WD repeat-containing protein 58", "protein_names_refseq": "THO complex 6 homolog; THO complex subunit 6 homolog; WD repeat-containing protein 58", "tax_id": 10116, "disease": "", "pathway": " (rno:79227); (R-RNO-159236)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Plays a role in apoptosis negative control involved in brain development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0000347 THO complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0000445 THO complex part of transcription export complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0006915 apoptotic process;GO:0007417 central nervous system development;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY87-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMD2-1", "uniprot_id": [ { "id": "SMBT1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JMD2", "type": "external" } ], "mass": 97506.0, "length": 863, "protein_name": "Scm-like with four MBT domains protein 1", "gene_name": "Sfmbt1", "organism": "Rat", "refseq_name": "scm-like with four MBT domains protein 1", "refseq_ac": [ { "id": "NP_113835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113835", "type": "external" } ], "gene_names_uniprotkb": "Sfmbt1", "gene_names_refseq": "Sfmbt1; Sfmbt", "protein_names_uniprotkb": "Scm-like with four MBT domains protein 1", "protein_names_refseq": "Scm-related gene containing four mbt domains; scm-like with four MBT domains protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:58967)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10806358;22673903", "class_list": "", "function": "Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q66HN3", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0048635 negative regulation of muscle organ development;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JMD2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXU2-1", "uniprot_id": [ { "id": "SURF1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QXU2", "type": "external" } ], "mass": 34683.0, "length": 306, "protein_name": "Surfeit locus protein 1", "gene_name": "Surf1; Surf4", "organism": "Rat", "refseq_name": "surfeit locus protein 1", "refseq_ac": [ { "id": "NP_742065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742065", "type": "external" } ], "gene_names_uniprotkb": "Surf1; Surf4; Surf-1; Surf1", "gene_names_refseq": "Ab1-205; Surf1", "protein_names_uniprotkb": "Surfeit locus protein 1", "protein_names_refseq": "surfeit 1; surfeit locus protein 1", "tax_id": 10116, "disease": "mitochondrial complex IV deficiency nuclear type 1 (Disease Ontology:DOID:0070491); Charcot-Marie-Tooth disease type 4K (Disease Ontology:DOID:0110187); Leigh disease (Disease Ontology:DOID:3652)", "pathway": " (rno:64463)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10622737", "class_list": "", "function": "Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004129 cytochrome-c oxidase activity;GO:0038024 cargo receptor activity;GO:0097020 COPII receptor activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0032368 regulation of lipid transport;GO:0090110 COPII-coated vesicle cargo loading;GO:0042953 lipoprotein transport;GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QXU2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PJ7-1", "uniprot_id": [ { "id": "ZN689_RAT", "url": "https://www.uniprot.org/uniprot/Q99PJ7", "type": "external" } ], "mass": 57282.0, "length": 500, "protein_name": "Zinc finger protein 689", "gene_name": "Zfp629; Zfp689; Znf689", "organism": "Rat", "refseq_name": "zinc finger protein 689", "refseq_ac": [ { "id": "NP_775452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775452", "type": "external" } ], "gene_names_uniprotkb": "Zfp629; Zfp689; Znf689; Hit39; Zfp689", "gene_names_refseq": "Hit39; Zfp689; Znf689", "protein_names_uniprotkb": "Zinc finger protein 689; Transcription factor HIT-39", "protein_names_refseq": "transcription factor HIT-39; zinc finger protein 689; zinc finger protein HIT-39", "tax_id": 10116, "disease": "", "pathway": " (rno:286996); (rno:308998); (R-RNO-212436)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0042393 histone binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q99PJ7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924U5-1", "uniprot_id": [ { "id": "TESK2_RAT", "url": "https://www.uniprot.org/uniprot/Q924U5", "type": "external" } ], "mass": 63559.0, "length": 570, "protein_name": "Dual specificity testis-specific protein kinase 2", "gene_name": "Tesk2", "organism": "Rat", "refseq_name": "dual specificity testis-specific protein kinase 2", "refseq_ac": [ { "id": "NP_596887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596887", "type": "external" } ], "gene_names_uniprotkb": "Tesk2", "gene_names_refseq": "Tesk2", "protein_names_uniprotkb": "Dual specificity testis-specific protein kinase 2; 2.7.12.1; Testicular protein kinase 2", "protein_names_refseq": "dual specificity testis-specific protein kinase 2; testicular protein kinase 2; testis-specific kinase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:170908)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11418599", "class_list": "", "function": "Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1A5M5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007283 spermatogenesis;GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q924U5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVC1-1", "uniprot_id": [ { "id": "SLIT2_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVC1", "type": "external" } ], "mass": 86049.0, "length": 766, "protein_name": "Slit homolog 2 protein", "gene_name": "Slit2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slit2", "gene_names_refseq": "", "protein_names_uniprotkb": "Slit homolog 2 protein; Slit-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); atrial fibrillation (Disease Ontology:DOID:0060224); polymyositis (Disease Ontology:DOID:0080745); dermatomyositis (Disease Ontology:DOID:10223); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); transient cerebral ischemia (Disease Ontology:DOID:224); cystic kidney disease (Disease Ontology:DOID:2975); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); diabetic retinopathy (Disease Ontology:DOID:8947); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (rno:360272)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10364234;11754167;15528323;38843836", "class_list": "", "function": "Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal cord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal cord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. Seems to be involved in regulating leukocyte migration (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004963 follicle-stimulating hormone receptor activity;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0043395 heparan sulfate proteoglycan binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0060603 mammary gland duct morphogenesis;GO:0090260 negative regulation of retinal ganglion cell axon guidance;GO:0002689 negative regulation of leukocyte chemotaxis;GO:0090027 negative regulation of monocyte chemotaxis;GO:0070100 negative regulation of chemokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WVC1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DGF4-1", "uniprot_id": [ { "id": "ZFAN6_RAT", "url": "https://www.uniprot.org/uniprot/Q6DGF4", "type": "external" } ], "mass": 24001.0, "length": 223, "protein_name": "AN1-type zinc finger protein 6", "gene_name": "Zfand6", "organism": "Rat", "refseq_name": "AN1-type zinc finger protein 6", "refseq_ac": [ { "id": "NP_001007631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007631", "type": "external" } ], "gene_names_uniprotkb": "Zfand6; Za20d3", "gene_names_refseq": "Za20d3; Zfand6; zgc:101121", "protein_names_uniprotkb": "AN1-type zinc finger protein 6; Zinc finger A20 domain-containing protein 3", "protein_names_refseq": "AN1-type zinc finger protein 6; protein associated with PRK1; zinc finger A20 domain-containing protein 3; zinc finger, A20 domain containing 3; zinc finger, AN1-type domain 6", "tax_id": 10116, "disease": "", "pathway": " (rno:293067); (R-RNO-9033241)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "18813897;21980954;23336395;23481562;27716383", "class_list": "", "function": "A20 is expressed in astrocytes after brain damage, and its overexpression is neurotoxic for cortical neurons in basal mixed neuron-glia culture conditions and exacerbates postnatal brain excitotoxic damage., [RefSeq, PubMed]; Involved in regulation of TNF induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity)., [UniProtKB]; It was observed that A20 was induced in rat kidneys exposed to ischaemia/reperfusion., [RefSeq, PubMed]; This study demonstrated that the Ischemia/reperfusion cortical neurons in MCAO rats are the main cell types that express A20, and there is a correlation between A20 expression and the suppression of neuroinflammation and the resulting neuroprotective effects. Publication Status: Online-Only, [RefSeq, PubMed]; Zinc finger protein A20 inhibits maturation of dendritic cells resident in rat liver allograft., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0015031 protein transport;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0071356 cellular response to tumor necrosis factor;GO:0043122 regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6DGF4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESZ0-1", "uniprot_id": [ { "id": "XRCC1_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESZ0", "type": "external" } ], "mass": 68836.0, "length": 631, "protein_name": "DNA repair protein XRCC1", "gene_name": "Xrcc1", "organism": "Rat", "refseq_name": "DNA repair protein XRCC1", "refseq_ac": [ { "id": "NP_445887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445887", "type": "external" } ], "gene_names_uniprotkb": "Xrcc1; Xrcc-1", "gene_names_refseq": "Xrcc1", "protein_names_uniprotkb": "DNA repair protein XRCC1; X-ray repair cross-complementing protein 1", "protein_names_refseq": "DNA repair protein XRCC1; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross-complementing protein 1; x-ray repair cross-complementing group 1 protein", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); myelodysplastic syndrome (Disease Ontology:DOID:0050908); brain glioma (Disease Ontology:DOID:0060108); colorectal carcinoma (Disease Ontology:DOID:0080199); autosomal recessive spinocerebellar ataxia 26 (Disease Ontology:DOID:0080260); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); asphyxia neonatorum (Disease Ontology:DOID:11088); hepatitis A (Disease Ontology:DOID:12549); leiomyoma (Disease Ontology:DOID:127); lung cancer (Disease Ontology:DOID:1324); malignant mesothelioma (Disease Ontology:DOID:1790); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); hepatitis B (Disease Ontology:DOID:2043); transient cerebral ischemia (Disease Ontology:DOID:224); laryngeal carcinoma (Disease Ontology:DOID:2600); transitional cell carcinoma (Disease Ontology:DOID:2671); contact dermatitis (Disease Ontology:DOID:2773); invasive ductal carcinoma (Disease Ontology:DOID:3008); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); gallbladder cancer (Disease Ontology:DOID:3121); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); meningioma (Disease Ontology:DOID:3565); liver cancer (Disease Ontology:DOID:3571); central nervous system cancer (Disease Ontology:DOID:3620); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); cervical cancer (Disease Ontology:DOID:4362); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); esophageal cancer (Disease Ontology:DOID:5041); liver cirrhosis (Disease Ontology:DOID:5082); stomach carcinoma (Disease Ontology:DOID:5517); gastric cardia carcinoma (Disease Ontology:DOID:6270); gastric cardia adenocarcinoma (Disease Ontology:DOID:6271); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic myeloid leukemia (Disease Ontology:DOID:8552); in situ carcinoma (Disease Ontology:DOID:8719); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease Ontology:DOID:9669); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:84495); (R-RNO-110381); (R-RNO-5649702); (R-RNO-5685939); (R-RNO-6782210)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity. Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 52, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6IRJ9", "ec_number_list": [], "go_molecular_function": "GO:0072572 poly-ADP-D-ribose binding;GO:0019899 enzyme binding;GO:0032356 oxidized DNA binding;GO:0160002 ADP-D-ribose modification-dependent protein binding;GO:1990165 single-strand break-containing DNA binding", "go_cellular_component": "GO:0070522 ERCC4-ERCC1 complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin", "go_biological_process": "GO:0061819 telomeric DNA-containing double minutes formation;GO:1905765 negative regulation of protection from non-homologous end joining at telomere;GO:0006281 DNA repair;GO:0001666 response to hypoxia;GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9ESZ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P5P3-1", "uniprot_id": [ { "id": "TTC9C_RAT", "url": "https://www.uniprot.org/uniprot/Q6P5P3", "type": "external" } ], "mass": 20067.0, "length": 171, "protein_name": "Tetratricopeptide repeat protein 9C", "gene_name": "Ttc9c", "organism": "Rat", "refseq_name": "tetratricopeptide repeat protein 9C", "refseq_ac": [ { "id": "NP_001007694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007694", "type": "external" } ], "gene_names_uniprotkb": "Ttc9c", "gene_names_refseq": "RGD1359253; Ttc9c", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 9C; TPR repeat protein 9C", "protein_names_refseq": "TPR domain containing protein RGD1359253; TPR repeat protein 9C; tetratricopeptide repeat protein 9C", "tax_id": 10116, "disease": "", "pathway": " (rno:309196)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P5P3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PEC1-1", "uniprot_id": [ { "id": "TBCA_RAT", "url": "https://www.uniprot.org/uniprot/Q6PEC1", "type": "external" } ], "mass": 12744.0, "length": 108, "protein_name": "Tubulin-specific chaperone A", "gene_name": "Tbca", "organism": "Rat", "refseq_name": "tubulin-specific chaperone A", "refseq_ac": [ { "id": "NP_001013263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013263", "type": "external" } ], "gene_names_uniprotkb": "Tbca", "gene_names_refseq": "Tbca", "protein_names_uniprotkb": "Tubulin-specific chaperone A; CFA; TCP1-chaperonin cofactor A; Tubulin-folding cofactor A", "protein_names_refseq": "CFA; TCP1-chaperonin cofactor A; tubulin cofactor a; tubulin-specific chaperone A", "tax_id": 10116, "disease": "", "pathway": " (rno:366995)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Tubulin-folding protein; involved in the early step of the tubulin folding pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015631 tubulin binding;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006457 protein folding;GO:0007021 tubulin complex assembly;GO:0007023 post-chaperonin tubulin folding pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PEC1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PCU2-1", "uniprot_id": [ { "id": "VATE1_RAT", "url": "https://www.uniprot.org/uniprot/Q6PCU2", "type": "external" } ], "mass": 26128.0, "length": 226, "protein_name": "V-type proton ATPase subunit E 1", "gene_name": "Atp6v1e1", "organism": "Rat", "refseq_name": "V-type proton ATPase subunit E 1", "refseq_ac": [ { "id": "NP_942040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942040", "type": "external" } ], "gene_names_uniprotkb": "Atp6v1e1", "gene_names_refseq": "Atp6e2; Atp6e; Atp6v1e1; P31; Vma4", "protein_names_uniprotkb": "V-type proton ATPase subunit E 1; V-ATPase subunit E 1; Vacuolar proton pump subunit E 1", "protein_names_refseq": "ATPase, H+ transporting, V1 subunit E; ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E; ATPase, H+ transporting, lysosomal V1 subunit E1; V-ATPase subunit E 1; V-type proton ATPase subunit E 1; VATPase, H+ transporting, lysosomal V1 subunit E1; vacuolar H(+)-ATPase, E subunit; vacuolar H+ ATPase E1; vacuolar proton pump subunit E 1", "tax_id": 10116, "disease": "autosomal recessive cutis laxa type IIC (Disease Ontology:DOID:0070140)", "pathway": " (rno:297566); (R-RNO-1222556); (R-RNO-77387); (R-RNO-917977); (R-RNO-9639288); (R-RNO-983712)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "32165585", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0097401 synaptic vesicle lumen acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PCU2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYH2-1", "uniprot_id": [ { "id": "IN80E_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYH2", "type": "external" } ], "mass": 26358.0, "length": 244, "protein_name": "INO80 complex subunit E", "gene_name": "Ino80e", "organism": "Rat", "refseq_name": "INO80 complex subunit E", "refseq_ac": [ { "id": "NP_001013922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013922", "type": "external" } ], "gene_names_uniprotkb": "Ino80e; Ccdc95", "gene_names_refseq": "Ccdc95; Ino80e", "protein_names_uniprotkb": "INO80 complex subunit E; Coiled-coil domain-containing protein 95", "protein_names_refseq": "INO80 complex subunit E; coiled-coil domain containing 95; coiled-coil domain-containing protein 95", "tax_id": 10116, "disease": "", "pathway": " (rno:293494); (R-RNO-5689603); (R-RNO-5696394)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0031011 Ino80 complex", "go_biological_process": "GO:0060382 regulation of DNA strand elongation;GO:0033044 regulation of chromosome organization;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYH2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ET20-1", "uniprot_id": [ { "id": "SCAM4_RAT", "url": "https://www.uniprot.org/uniprot/Q9ET20", "type": "external" } ], "mass": 25512.0, "length": 230, "protein_name": "Secretory carrier-associated membrane protein 4", "gene_name": "Scamp4", "organism": "Rat", "refseq_name": "secretory carrier-associated membrane protein 4", "refseq_ac": [ { "id": "NP_113913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113913", "type": "external" } ], "gene_names_uniprotkb": "Scamp4", "gene_names_refseq": "Scamp4", "protein_names_uniprotkb": "Secretory carrier-associated membrane protein 4; SCAMP-4; Secretory carrier membrane protein 4", "protein_names_refseq": "SCAMP-4; secretory carrier-associated membrane protein 4", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (rno:65170)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11295240", "class_list": "", "function": "Probably involved in membrane protein trafficking., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0032588 trans-Golgi network membrane;GO:0055038 recycling endosome membrane;GO:0016020 membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006887 exocytosis;GO:0019098 reproductive behavior", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9ET20-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXT8-1", "uniprot_id": [ { "id": "SF3A2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXT8", "type": "external" } ], "mass": 49890.0, "length": 471, "protein_name": "Splicing factor 3A subunit 2", "gene_name": "Sf3a2", "organism": "Rat", "refseq_name": "splicing factor 3A subunit 2", "refseq_ac": [ { "id": "NP_001011986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011986", "type": "external" } ], "gene_names_uniprotkb": "Sf3a2", "gene_names_refseq": "Sf3a2", "protein_names_uniprotkb": "Splicing factor 3A subunit 2", "protein_names_refseq": "splicing factor 3A subunit 2; splicing factor 3a, subunit 2, 66kDa", "tax_id": 10116, "disease": "", "pathway": " (rno:299620); (R-RNO-72163); (R-RNO-9770562); (R-RNO-9943411)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0010976 positive regulation of neuron projection development;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:1903241 U2-type prespliceosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXT8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z200-1", "uniprot_id": [ { "id": "SH2B2_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z200", "type": "external" } ], "mass": 66708.0, "length": 621, "protein_name": "SH2B adapter protein 2", "gene_name": "Sh2b2", "organism": "Rat", "refseq_name": "SH2B adapter protein 2", "refseq_ac": [ { "id": "NP_446121", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446121", "type": "external" } ], "gene_names_uniprotkb": "Sh2b2; Aps", "gene_names_refseq": "Aps; Sh2b2", "protein_names_uniprotkb": "SH2B adapter protein 2; Adapter protein with pleckstrin homology and Src homology 2 domains; SH2 and PH domain-containing adapter protein APS", "protein_names_refseq": "SH2 and PH domain-containing adapter protein APS; SH2B adapter protein 2; adapter protein with pleckstrin homology and Src homology 2 domains; adaptor protein with pleckstrin homology and src homology 2 domains", "tax_id": 10116, "disease": "chromosome 16p11.2 deletion syndrome, 220-kb (Disease Ontology:DOID:0060398)", "pathway": " (rno:114203); (R-RNO-1433559); (R-RNO-983231)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10854852;11997497;14690593;15031295;15231829;16141217;22673903;9856458", "class_list": "", "function": "APS was identified as a novel substrate for protein kinase B/Akt., [RefSeq, PubMed]; Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis (By similarity). Involved in stimulation of glucose uptake by insulin. Involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Induces cytoskeletal reorganization and neurite outgrowth in cultured neurons., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042169 SH2 domain binding;GO:0035591 signaling adaptor activity;GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0001725 stress fiber;GO:0001726 ruffle", "go_biological_process": "GO:0007399 nervous system development;GO:0035556 intracellular signal transduction;GO:0050873 brown fat cell differentiation;GO:0030036 actin cytoskeleton organization;GO:0050776 regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z200-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z144-1", "uniprot_id": [ { "id": "LEG2_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z144", "type": "external" } ], "mass": 14733.0, "length": 130, "protein_name": "Galectin-2", "gene_name": "Lgals2", "organism": "Rat", "refseq_name": "galectin-2", "refseq_ac": [ { "id": "NP_598283", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598283", "type": "external" } ], "gene_names_uniprotkb": "Lgals2", "gene_names_refseq": "Lgals2", "protein_names_uniprotkb": "Galectin-2; Gal-2", "protein_names_refseq": "gal-2; galectin-2; lectin, galactoside-binding, soluble, 2 (galectin 2)", "tax_id": 10116, "disease": "myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:171134)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18064431;9882446", "class_list": "", "function": "Galectin-2 treatment induced apoptosis of mucosal T cells and thus ameliorated acute and chronic dextran-sodium-sulfate-induced colitis and in a T-helper-cell 1-driven model of antigen-specific transfer colitis., [RefSeq, PubMed]; This protein binds beta-galactoside. Its physiological function is not yet known., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0016936 galactoside binding", "go_cellular_component": "GO:1990724 galectin complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0098609 cell-cell adhesion;GO:0050729 positive regulation of inflammatory response;GO:0043029 T cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z144-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1S9-1", "uniprot_id": [ { "id": "MK_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1S9", "type": "external" } ], "mass": 15406.0, "length": 140, "protein_name": "Midkine", "gene_name": "Mdk", "organism": "Rat", "refseq_name": "midkine precursor", "refseq_ac": [ { "id": "NP_110486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110486", "type": "external" } ], "gene_names_uniprotkb": "Mdk", "gene_names_refseq": "Mdk", "protein_names_uniprotkb": "Midkine; MK", "protein_names_refseq": "MK; midkine precursor", "tax_id": 10116, "disease": "brain ischemia (Disease Ontology:DOID:2316); endometriosis (Disease Ontology:DOID:289); brain infarction (Disease Ontology:DOID:3454); coronary stenosis (Disease Ontology:DOID:4248); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:81517); (R-RNO-201556); (R-RNO-9851151)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10683378;11136554;1768439;28392548;31972179;36731809", "class_list": "", "function": "Dahuang Zhechong pill attenuates hepatic sinusoidal capillarization in liver cirrhosis and hepatocellular carcinoma rat model via the MK/integrin signaling pathway., [RefSeq, PubMed]; Data suggest that retinoic acid up-regulates Mdk gene expression via Rar signaling in neurons of anterior pituitary which also express Raldh1. (Mdk = midkine; Rar = retinoic acid receptor; Raldh1= retinaldehyde dehydrogenase 1), [RefSeq, PubMed]; Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity)., [UniProtKB, PubMed, PubMed]; MiR-326 targets MDK to regulate the progression of cardiac hypertrophy through blocking JAK/STAT and MAPK signaling pathways., [RefSeq, PubMed]; Secreted protein that functions as a cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups. Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration. Participates in inflammatory processes by exerting two different activities (By similarity). Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression (PubMed:10683378). This inflammation can be accompanied by epithelial cell survival and smooth muscle cell migration after renal and vessel damage, respectively. Secondly, suppresses the development of tolerogenic dendric cells thereby inhibiting the differentiation of regulatory T cells and also promote T cell expansion through NFAT signaling and Th1 cell differentiation (By similarity). Promotes tissue regeneration after injury or trauma. After heart damage negatively regulates the recruitment of inflammatory cells and mediates cell survival through activation of anti-apoptotic signaling pathways via MAPKs and AKT pathways through the activation of angiogenesis. Also facilitates liver regeneration as well as bone repair by recruiting macrophage at trauma site and by promoting cartilage development by facilitating chondrocyte differentiation. Plays a role in brain by promoting neural precursor cells survival and growth through interaction with heparan sulfate proteoglycans (By similarity). Binds PTPRZ1 and promotes neuronal migration and embryonic neurons survival. Binds SDC3 or GPC2 and mediates neurite outgrowth and cell adhesion. Binds chondroitin sulfate E and heparin leading to inhibition of neuronal cell adhesion induced by binding with GPC2 (By similarity). Binds CSPG5 and promotes elongation of oligodendroglial precursor-like cells (By similarity). Also binds ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth. Binds LRP1; promotes neuronal survival. Binds ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Promotes epithelial to mesenchymal transition through interaction with NOTCH2 (By similarity). During arteriogenesis, plays a role in vascular endothelial cell proliferation by inducing VEGFA expression and release which in turn induces nitric oxide synthase expression. Moreover activates vasodilation through nitric oxide synthase activation. Negatively regulates bone formation in response to mechanical load by inhibiting Wnt/beta-catenin signaling in osteoblasts (By similarity). In addition plays a role in hippocampal development, working memory, auditory response, early fetal adrenal gland development and the female reproductive system (By similarity) (PubMed:11136554)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:1904399 heparan sulfate binding;GO:0008083 growth factor activity;GO:0035374 chondroitin sulfate binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0042995 cell projection", "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell;GO:1904036 negative regulation of epithelial cell apoptotic process;GO:0021681 cerebellar granular layer development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9R1S9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDA5-1", "uniprot_id": [ { "id": "ZBP1_RAT", "url": "https://www.uniprot.org/uniprot/Q8VDA5", "type": "external" } ], "mass": 43918.0, "length": 409, "protein_name": "Z-DNA-binding protein 1", "gene_name": "Zbp1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zbp1; Dlm1", "gene_names_refseq": "", "protein_names_uniprotkb": "Z-DNA-binding protein 1; Tumor stroma and activated macrophage protein DLM-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:171091)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11842111", "class_list": "", "function": "Key innate sensor that recognizes and binds Z-RNA structures, which are produced by a number of viruses, such as herpesvirus, orthomyxovirus or flavivirus, and triggers different forms of cell death. ZBP1 acts as an essential mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, by activating RIPK3, caspase-8 (CASP8), and the NLRP3 inflammasome. Key activator of necroptosis, a programmed cell death process in response to death-inducing TNF family members, via its ability to bind Z-RNA: once activated upon Z-RNA-binding, ZBP1 interacts and stimulates RIPK3 kinase, which phosphorylates and activates MLKL, triggering execution of programmed necrosis. In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: ZBP1 recognizes and binds Z-RNA structures that are produced in infected nuclei by orthomyxoviruses, such as the influenza A virus (IAV), leading to ZBP1 activation, RIPK3 stimulation and subsequent MLKL phosphorylation, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol. ZBP1-dependent cell death in response to IAV infection promotes interleukin-1 alpha (IL1A) induction in an NLRP3-inflammasome-independent manner: IL1A expression is required for the optimal interleukin-1 beta (IL1B) production, and together, these cytokines promote infiltration of inflammatory neutrophils to the lung, leading to the formation of neutrophil extracellular traps. In addition to its direct role in driving necroptosis via its ability to sense Z-RNAs, also involved in PANoptosis triggered in response to bacterial infection: component of the AIM2 PANoptosome complex, a multiprotein complex that triggers PANoptosis. Also acts as the apical sensor of fungal infection responsible for activating PANoptosis. Involved in CASP8-mediated cell death via its interaction with RIPK1 but independently of its ability to sense Z-RNAs. In some cell types, also able to restrict viral replication by promoting cell death-independent responses. In response to flavivirus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with RIPK3, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate. Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003692 left-handed Z-DNA binding;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:2000659 regulation of interleukin-1-mediated signaling pathway;GO:0043065 positive regulation of apoptotic process;GO:0051607 defense response to virus;GO:0006915 apoptotic process;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VDA5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQJ4-1", "uniprot_id": [ { "id": "ZN384_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQJ4", "type": "external" } ], "mass": 63139.0, "length": 579, "protein_name": "Zinc finger protein 384", "gene_name": "Zfp384; Znf384", "organism": "Rat", "refseq_name": "zinc finger protein 384 isoform 1", "refseq_ac": [ { "id": "NP_001030002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030002", "type": "external" } ], "gene_names_uniprotkb": "Zfp384; Znf384; Ciz; Nmp4; Zfp384", "gene_names_refseq": "Ciz; Nmp4; Zfp384; Znf384", "protein_names_uniprotkb": "Zinc finger protein 384; Cas-associated zinc finger protein; Nuclear matrix protein 4; Nuclear matrix transcription factor 4", "protein_names_refseq": "Cas-associated zinc finger protein; nuclear matrix protein 4; nuclear matrix transcription factor 4; zinc finger protein 384 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:171018)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10669742;11149472;12052465;15026307;18211825", "class_list": "", "function": "Localization in the cytoplasm of osteoblasts[Nmp4 - nuclear matrix protein 4], [RefSeq, PubMed]; Nmp4/CIZ is a component of a multiprotein assemblage or enhanceosome within the MMP-13 parathyroid hormone response region and that, within this context, Nmp4/CIZ promotes both basal expression and hormonal synergy., [RefSeq, PubMed]; These results revealed that Ciz interacts with C-propeptides of type I collagen and this association takes place in nuclei., [RefSeq, PubMed]; Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQJ2;Q9EQJ3;Q9JMJ5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005925 focal adhesion", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006913 nucleocytoplasmic transport;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050714 positive regulation of protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9EQJ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1V3-1", "uniprot_id": [ { "id": "SMAD5_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1V3", "type": "external" } ], "mass": 52215.0, "length": 465, "protein_name": "SMAD family member 5", "gene_name": "Smad5", "organism": "Rat", "refseq_name": "SMAD family member 5", "refseq_ac": [ { "id": "NP_067724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067724", "type": "external" } ], "gene_names_uniprotkb": "Smad5; Madh5", "gene_names_refseq": "Madh5; Smad5", "protein_names_uniprotkb": "SMAD family member 5; MAD homolog 5; Mothers against DPP homolog 5; Mothers against decapentaplegic homolog 5; SMAD 5", "protein_names_refseq": "MAD homolog 5; SMAD 5; SMAD family member 5; SMAD, mothers against DPP homolog 5; mothers against DPP homolog 5; mothers against decapentaplegic homolog 5", "tax_id": 10116, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787)", "pathway": " (rno:59328); (R-RNO-201451)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11527422;22673903;26687945;27035233;28202235;35170385", "class_list": "", "function": "Cpd 861 markedly upregulated the gene expression of BMP7 and Smad5, as well as the protein expression of BMP7 and Smad1/5. In addition, p-Smad1/5/8 protein expression was markedly increased by Cpd 861 in the liver fibrosis model., [RefSeq, PubMed]; MiR-122-5p promotes peritoneal fibrosis in a rat model of peritoneal dialysis by targeting Smad5 to activate Wnt/beta-catenin pathway., [RefSeq, PubMed]; Taken together, these results indicated that FSTL1 protects the SNP-induced injury in cardiac H9c2 cells through, at least in part, the activation of Akt and inhibition of Smad1/5/9 signaling., [RefSeq, PubMed]; The activation and regulation of STX12, miR-148a and SMAD5 in pancreatic stellate cells may serve as a new gene therapy strategy for the treatment of chronic pancreatitis and reversal of pancreatic fibrosis., [RefSeq, PubMed]; Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis. Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor. In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network. Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes. Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0002051 osteoblast fate commitment;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9R1V3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R512-1", "uniprot_id": [ { "id": "UBX11_RAT", "url": "https://www.uniprot.org/uniprot/Q8R512", "type": "external" } ], "mass": 54721.0, "length": 485, "protein_name": "UBX domain-containing protein 11", "gene_name": "Ubxn11", "organism": "Rat", "refseq_name": "UBX domain-containing protein 11", "refseq_ac": [ { "id": "NP_620208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620208", "type": "external" } ], "gene_names_uniprotkb": "Ubxn11; Soc; Ubxd5", "gene_names_refseq": "Soc; Ubxd5; Ubxn11", "protein_names_uniprotkb": "UBX domain-containing protein 11; Socius; UBX domain-containing protein 5", "protein_names_refseq": "UBX domain containing 5; UBX domain-containing protein 11; UBX domain-containing protein 5; socius", "tax_id": 10116, "disease": "", "pathway": " (rno:192207); (R-RNO-9696264); (R-RNO-9696270); (R-RNO-9696273)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11940653;16202387", "class_list": "", "function": "May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R512-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYK2-1", "uniprot_id": [ { "id": "JMJD6_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYK2", "type": "external" } ], "mass": 46540.0, "length": 403, "protein_name": "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6", "gene_name": "Jmjd6", "organism": "Rat", "refseq_name": "bifunctional arginine demethylase and lysyl-hydroxylase JMJD6", "refseq_ac": [ { "id": "NP_001012143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012143", "type": "external" } ], "gene_names_uniprotkb": "Jmjd6; Ptdsr", "gene_names_refseq": "Jmjd6; Ptdsr", "protein_names_uniprotkb": "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; 1.14.11.-; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-dioxygenase JMJD6; Phosphatidylserine receptor; Protein PTDSR", "protein_names_refseq": "arginine demethylase and lysine hydroxylase; bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; histone arginine demethylase JMJD6; jmjC domain-containing protein 6; jumonji domain-containing protein 6; lysyl-hydroxylase JMJD6; peptide-lysine 5-dioxygenase JMJD6; phosphatidylserine receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:360665); (R-RNO-3214842); (R-RNO-9629569)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "29620141", "class_list": "", "function": "Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization (By similarity). Plays a role in the regulation of nucleolar liquid-liquid phase separation (LLPS) by post-translationally modifying LIAT1 at its lysine-rich domain which inhibits LIAT1 nucleolar targeting (By similarity). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation. Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation. Demethylates other arginine methylated-proteins such as ESR1. Has no histone lysine demethylase activity (By similarity). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; JMJD6 may exert its therapeutic function in neuropathic pain by regulating NFkappaB following chronic constriction injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" } ], "go_molecular_function": "GO:0033746 histone H3R2 demethylase activity;GO:0033749 histone H4R3 demethylase activity;GO:0070815 peptidyl-lysine 5-dioxygenase activity;GO:0003723 RNA binding;GO:0005506 iron ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0018395 peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYK2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6X782-1", "uniprot_id": [ { "id": "ZPBP2_RAT", "url": "https://www.uniprot.org/uniprot/Q6X782", "type": "external" } ], "mass": 36795.0, "length": 326, "protein_name": "Zona pellucida-binding protein 2", "gene_name": "Zpbp2", "organism": "Rat", "refseq_name": "zona pellucida-binding protein 2 precursor", "refseq_ac": [ { "id": "NP_001007012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007012", "type": "external" } ], "gene_names_uniprotkb": "Zpbp2", "gene_names_refseq": "Zpbp2", "protein_names_uniprotkb": "Zona pellucida-binding protein 2", "protein_names_refseq": "zona pellucida-binding protein 2 precursor", "tax_id": 10116, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); asthma (Disease Ontology:DOID:2841); lung squamous cell carcinoma (Disease Ontology:DOID:3907); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:363676)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Is implicated in sperm-oocyte interaction during fertilization., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6X781", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane;GO:0001669 acrosomal vesicle;GO:0044297 cell body;GO:0002199 zona pellucida receptor complex", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0006665 sphingolipid metabolic process;GO:0001675 acrosome assembly;GO:0032922 circadian regulation of gene expression;GO:0046466 membrane lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6X782-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1A5-1", "uniprot_id": [ { "id": "ULA1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1A5", "type": "external" } ], "mass": 60383.0, "length": 534, "protein_name": "NEDD8-activating enzyme E1 regulatory subunit", "gene_name": "Nae1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nae1; Appbp1", "gene_names_refseq": "", "protein_names_uniprotkb": "NEDD8-activating enzyme E1 regulatory subunit; APP-BP1; Amyloid beta precursor protein-binding protein 1, 59 kDa; Amyloid protein-binding protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (rno:84019)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14557245;8626687", "class_list": "", "function": "Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation (PubMed:14557245). The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0019781 NEDD8 activating enzyme activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0051402 neuron apoptotic process;GO:0042981 regulation of apoptotic process;GO:0043523 regulation of neuron apoptotic process;GO:0045116 protein neddylation;GO:0033314 mitotic DNA replication checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z1A5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZR6-1", "uniprot_id": [ { "id": "SEPT9_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZR6", "type": "external" } ], "mass": 63792.0, "length": 564, "protein_name": "Septin-9", "gene_name": "Septin9", "organism": "Rat", "refseq_name": "septin-9 isoform 3", "refseq_ac": [ { "id": "NP_001106969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106969", "type": "external" } ], "gene_names_uniprotkb": "Septin9; Sept9", "gene_names_refseq": "Eseptin; Msf; Sept9; Septin9l1; Septin9; Slpa", "protein_names_uniprotkb": "Septin-9; Eighth septin; Eseptin; SLP; Septin-like protein", "protein_names_refseq": "E-septin; MLL septin-like fusion; SLP; eighth septin; septin 9-like 1; septin-9 isoform 3; septin-9-like; septin-like protein", "tax_id": 10116, "disease": "brachial plexus neuritis (Disease Ontology:DOID:3689); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:83788)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10371165;10944462;12388755;15485874;16641100;17546647;17922164;22673903;26823018;36012625", "class_list": "", "function": "Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)., [UniProtKB]; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SEPT9 Upregulation in Satellite Glial Cells Associated with Diabetic Polyneuropathy in a Type 2 Diabetes-like Rat Model. Publication Status: Online-Only, [RefSeq, PubMed]; Sept7/9b/11 form a complex that has effects on filament elongation, bundling, or disruption, [RefSeq, PubMed]; The first evidence of an interaction between septins and a nonmitotic kinesin is provided and it is suggested that SEPT9 modulates the interactions of KIF17 with membrane cargo., [RefSeq, PubMed]; These results reveal that MSF is required for the completion of cytokinesis and suggest a role that is distinct from that of Nedd5., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZJ7;Q9QZJ8;Q9QZP9", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005940 septin ring;GO:0005874 microtubule;GO:0005929 cilium;GO:0015629 actin cytoskeleton;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization;GO:0008104 intracellular protein localization;GO:0032185 septin cytoskeleton organization;GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QZR6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXX3-1", "uniprot_id": [ { "id": "Z385D_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXX3", "type": "external" } ], "mass": 42480.0, "length": 395, "protein_name": "Zinc finger protein 385D", "gene_name": "Zfp385d; Znf385d", "organism": "Rat", "refseq_name": "zinc finger protein 385D", "refseq_ac": [ { "id": "NP_001014014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014014", "type": "external" } ], "gene_names_uniprotkb": "Zfp385d; Znf385d; Znf659", "gene_names_refseq": "Zfp385d; Znf385d", "protein_names_uniprotkb": "Zinc finger protein 385D; Zinc finger protein 659", "protein_names_refseq": "zinc finger protein 385D; zinc finger protein 659", "tax_id": 10116, "disease": "", "pathway": " (rno:305691)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXX3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXZ5-1", "uniprot_id": [ { "id": "ZMY10_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXZ5", "type": "external" } ], "mass": 50675.0, "length": 440, "protein_name": "Zinc finger MYND domain-containing protein 10", "gene_name": "Zmynd10", "organism": "Rat", "refseq_name": "zinc finger MYND domain-containing protein 10", "refseq_ac": [ { "id": "NP_001004284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004284", "type": "external" } ], "gene_names_uniprotkb": "Zmynd10", "gene_names_refseq": "Zmynd10", "protein_names_uniprotkb": "Zinc finger MYND domain-containing protein 10", "protein_names_refseq": "zinc finger MYND domain-containing protein 10; zinc finger, MYND domain-containing 10", "tax_id": 10116, "disease": "idiopathic scoliosis (Disease Ontology:DOID:0060250); primary ciliary dyskinesia 22 (Disease Ontology:DOID:0110597); sensorineural hearing loss (Disease Ontology:DOID:10003); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (rno:363139)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23891469", "class_list": "", "function": "Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity). May act by indirectly regulating transcription of dynein proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016324 apical plasma membrane;GO:0034451 centriolar satellite;GO:0120293 dynein axonemal particle", "go_biological_process": "GO:0006457 protein folding;GO:0044458 motile cilium assembly;GO:0061512 protein localization to cilium;GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXZ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TEK4-1", "uniprot_id": [ { "id": "VKOR1_RAT", "url": "https://www.uniprot.org/uniprot/Q6TEK4", "type": "external" } ], "mass": 17783.0, "length": 161, "protein_name": "Vitamin K epoxide reductase complex subunit 1", "gene_name": "Prss53; Vkorc1", "organism": "Rat", "refseq_name": "vitamin K epoxide reductase complex subunit 1", "refseq_ac": [ { "id": "NP_976080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_976080", "type": "external" } ], "gene_names_uniprotkb": "Prss53; Vkorc1", "gene_names_refseq": "Vkorc1", "protein_names_uniprotkb": "Vitamin K epoxide reductase complex subunit 1; 1.17.4.4; Vitamin K1 2,3-epoxide reductase subunit 1", "protein_names_refseq": "Warfarin resistance; phylloquinone epoxide reductase; vitamin K epoxide reductase complex subunit 1; vitamin K1 2,3-epoxide reductase subunit 1; vitamin K1 epoxide reductase (warfarin-sensitive)", "tax_id": 10116, "disease": "warfarin resistance (Disease Ontology:DOID:0080665); warfarin sensitivity (Disease Ontology:DOID:0080666); combined deficiency of vitamin K-dependent clotting factors 2 (Disease Ontology:DOID:0112174)", "pathway": " (rno:309004); (R-RNO-6806664)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14765194;14765195;15640149;15879509;23772386;23928358;35296766;35430058;35970209;36309944;37151288", "class_list": "", "function": "Distribution of non-synonymous Vkorc1 mutations in roof rats (Rattus rattus) in France and in Spain - consequences for management., [RefSeq, PubMed]; Identified, by using linkage information from three species the gene VKORC1 which encodes a small transmembrane protein of the endoplasmic reticulum; VKORC1 contains missense mutations in both human disorders and in a warfarin-resistant rat strain, [RefSeq, PubMed]; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator., [UniProtKB, UniProtKB, UniProtKB]; Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Large-scale identification of rodenticide resistance in Rattus norvegicus and Mus musculus in the Netherlands based on Vkorc1 codon 139 mutations., [RefSeq, PubMed]; VKORC1 mutations in rodent populations of a tropical city-state as an indicator of anticoagulant rodenticide resistance. Publication Status: Online-Only, [RefSeq, PubMed]; VKORC1 single nucleotide polymorphisms in rodents in Spain., [RefSeq, PubMed]; Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. [provided by RefSeq, Jul 2008]., [RefSeq]; Vkorc1 gene polymorphisms confer resistance to anticoagulant rodenticide in Turkish rats. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.17.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.17.4.4", "type": "external" } ], "go_molecular_function": "GO:0047057 vitamin-K-epoxide reductase (warfarin-sensitive) activity;GO:0047058 vitamin-K-epoxide reductase (warfarin-insensitive) activity;GO:0048038 quinone binding;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0007596 blood coagulation;GO:0006805 xenobiotic metabolic process;GO:0060348 bone development;GO:0030193 regulation of blood coagulation;GO:0017187 peptidyl-glutamic acid carboxylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6TEK4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZI7-1", "uniprot_id": [ { "id": "TSAP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZI7", "type": "external" } ], "mass": 32454.0, "length": 287, "protein_name": "tRNA selenocysteine 1-associated protein 1", "gene_name": "Trnau1ap", "organism": "Rat", "refseq_name": "tRNA selenocysteine 1-associated protein 1 isoform 1", "refseq_ac": [ { "id": "NP_075416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075416", "type": "external" } ], "gene_names_uniprotkb": "Trnau1ap; Secp43; Trspap1", "gene_names_refseq": "Secp43; Trnau1ap; Trspap1", "protein_names_uniprotkb": "tRNA selenocysteine 1-associated protein 1; SECp43; tRNA selenocysteine-associated protein 1", "protein_names_refseq": "tRNA selenocysteine 1-associated protein 1 isoform 1; tRNA selenocysteine 1-associated protein 1-like; tRNA selenocysteine associated protein; tRNA selenocysteine-associated protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:65241)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10606267;28101579", "class_list": "", "function": "Downregulation of Trnau1ap inhibits the proliferation of cardiomyocytelike H9c2 cells. Downregulation of Trnau1ap induces apoptosis., [RefSeq, PubMed]; Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0001514 selenocysteine incorporation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QZI7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99ND9-1", "uniprot_id": [ { "id": "RWDD1_RAT", "url": "https://www.uniprot.org/uniprot/Q99ND9", "type": "external" } ], "mass": 27782.0, "length": 243, "protein_name": "RWD domain-containing protein 1", "gene_name": "Rwdd1", "organism": "Rat", "refseq_name": "RWD domain-containing protein 1", "refseq_ac": [ { "id": "NP_671487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_671487", "type": "external" } ], "gene_names_uniprotkb": "Rwdd1; Sarip", "gene_names_refseq": "Rwdd1; sarip", "protein_names_uniprotkb": "RWD domain-containing protein 1; Small androgen receptor-interacting protein", "protein_names_refseq": "RWD domain-containing protein 1; small androgen receptor-interacting protein", "tax_id": 10116, "disease": "", "pathway": " (rno:259218)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protects DRG2 from proteolytic degradation (By similarity). May function as a coactivator of the AR/androgen receptor transcription factor during development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Protects DRG2 from proteolytic degradation. May function as a coactivator of the AR/androgen receptor transcription factor during development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6K3S3", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0030521 androgen receptor signaling pathway;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q99ND9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZT1-1", "uniprot_id": [ { "id": "VGFR3_RAT", "url": "https://www.uniprot.org/uniprot/Q91ZT1", "type": "external" } ], "mass": 153317.0, "length": 1363, "protein_name": "Vascular endothelial growth factor receptor 3", "gene_name": "Flt4", "organism": "Rat", "refseq_name": "vascular endothelial growth factor receptor 3 precursor", "refseq_ac": [ { "id": "NP_446104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446104", "type": "external" } ], "gene_names_uniprotkb": "Flt4; Flt-4; Vegfr3", "gene_names_refseq": "Flt4; Vegfr3", "protein_names_uniprotkb": "Vascular endothelial growth factor receptor 3; 2.7.10.1; FLT-4; Fms-like tyrosine kinase 4; Tyrosine-protein kinase receptor FLT4; VEGFR-3", "protein_names_refseq": "FLT-4; FMS-like tyrosine kinase 4; VEGFR-3; fms-related tyrosine kinase 4; tyrosine-protein kinase receptor FLT4; vascular endothelial growth factor receptor 3 precursor; vascular endothelial growth factor receptor 3", "tax_id": 10116, "disease": "hereditary lymphedema (Disease Ontology:DOID:0050580); hereditary lymphedema IA (Disease Ontology:DOID:0070210); lymphangioma (Disease Ontology:DOID:1475); cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); thyroid gland carcinoma (Disease Ontology:DOID:3963); systemic scleroderma (Disease Ontology:DOID:418); nephrolithiasis (Disease Ontology:DOID:585)", "pathway": " (rno:114110); (R-RNO-195399)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10878616;25943477;31757960;38728943", "class_list": "", "function": "MiR-455-3p regulates lymphangiogenesis in silicosis by regulating VEGF-C/VEGFR3., [RefSeq, PubMed]; The findings of this study suggest an important role for VEGFC/VEGFR3 signaling in neuronal proliferation in early forebrain development, and ongoing functions with niche neurogenesis, glial and ependymal function in the maturing postnatal brain., [RefSeq, PubMed]; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473' (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; VEGF-C/VEGFR3 signaling activates lymphatic endothelium in cervical lymph nodes after ischemic stroke. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 12, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "O35755;Q91ZT0", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0042803 protein homodimerization activity;GO:0019903 protein phosphatase binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0005829 cytosol", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0003016 respiratory system process;GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration;GO:0018108 peptidyl-tyrosine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91ZT1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFM6-1", "uniprot_id": [ { "id": "STAB2_RAT", "url": "https://www.uniprot.org/uniprot/Q8CFM6", "type": "external" } ], "mass": 155914.0, "length": 1431, "protein_name": "Stabilin-2", "gene_name": "Stab2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Stab2; Feel2; Hare", "gene_names_refseq": "", "protein_names_uniprotkb": "Stabilin-2; 175 kDa hyaluronan receptor for endocytosis; FEEL-2; Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2; Hyaluronan receptor for endocytosis", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "12181351;15572036;17450384;19359419;21454685;9061360", "class_list": "", "function": "Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Also acts, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 175 kDa form also functions as an endocytosis receptor for heparin internalization as well as HA and CS., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 16, "predicted_n_glycosites": 15, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0005509 calcium ion binding;GO:0005041 low-density lipoprotein particle receptor activity;GO:0030169 low-density lipoprotein particle binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007155 cell adhesion;GO:0050830 defense response to Gram-positive bacterium;GO:0006898 receptor-mediated endocytosis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CFM6-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6U6G5-1", "uniprot_id": [ { "id": "ZC3HF_RAT", "url": "https://www.uniprot.org/uniprot/Q6U6G5", "type": "external" } ], "mass": 48299.0, "length": 426, "protein_name": "Zinc finger CCCH domain-containing protein 15", "gene_name": "Zc3h15", "organism": "Rat", "refseq_name": "zinc finger CCCH domain-containing protein 15", "refseq_ac": [ { "id": "NP_001010963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010963", "type": "external" } ], "gene_names_uniprotkb": "Zc3h15", "gene_names_refseq": "Zc3h15", "protein_names_uniprotkb": "Zinc finger CCCH domain-containing protein 15; p48ZnF", "protein_names_refseq": "brain zinc finger protein; p48ZnF; zinc finger CCCH domain-containing protein 15", "tax_id": 10116, "disease": "", "pathway": " (rno:362154); (R-RNO-9629569)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15150441;22673903;23470633", "class_list": "", "function": "P48ZnF is up-regulated in rat neuronal PC12 cells upon stimulation with the neurotrophic factor NGF, [RefSeq, PubMed]; P48ZnF' cellular location of action depends on the cell's differentiation status: nuclear in proliferating cells and cytoplasmic in differentiated neurons., [RefSeq, PubMed]; Protects DRG1 from proteolytic degradation. Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0043547 positive regulation of GTPase activity;GO:0019221 cytokine-mediated signaling pathway;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6U6G5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPZ7-1", "uniprot_id": [ { "id": "SO1C1_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPZ7", "type": "external" } ], "mass": 78627.0, "length": 716, "protein_name": "Solute carrier organic anion transporter family member 1C1", "gene_name": "Slco1c1", "organism": "Rat", "refseq_name": "solute carrier organic anion transporter family member 1C1", "refseq_ac": [ { "id": "NP_445893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445893", "type": "external" } ], "gene_names_uniprotkb": "Slco1c1; Bsat1; Oatp1c1; Oatpf; Slc21a14", "gene_names_refseq": "BAST1; Bsat1; OATP-14; OATP1C1; Oatp14; Slc21a14; Slco1c1", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 1C1; BAST1; BBB-specific anion transporter type 1; Blood-brain barrier-specific anion transporter 1; OATP-14; OATP1C1; Organic anion transporter 1C1; Organic anion-transporting polypeptide 14; Solute carrier family 21 member 14; Thyroxine transporter", "protein_names_refseq": "BBB-specific anion transporter type 1; blood-brain barrier specific anion transporter; blood-brain barrier-specific anion transporter 1; organic anion transporter 1C1; organic anion-transporting polypeptide 14; solute carrier family 21 (organic anion transporter), member 14; solute carrier family 21 member 14; solute carrier organic anion transporter family member 1C1; thyroxine transporter", "tax_id": 10116, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236)", "pathway": " (rno:84511); (R-RNO-879518)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11149669;12923172;17667996;18687783;19819953;24090084;25594699;26861177;28688524;31561916;32636400;38843836", "class_list": "", "function": "CRISRP/Cas9-mediated knockout of Mct8 reveals a functional involvement of Mct8 in testis and sperm development in a rat. Erratum:[Sci Rep. 2020 Nov 11;10(1):19967. doi: 10.1038/s41598-020-76579-0. PMID: 33177632] Publication Status: Online-Only, [RefSeq, PubMed]; Differential expression and immunoreactivity of thyroid hormone transporters MCT8 and OATP1C1 in rat ovary., [RefSeq, PubMed]; Mediates the Na(+)-independent high affinity transport of thyroid hormones at the plasma membrane of brain capillary endothelial cells (PubMed:12923172, PubMed:17667996, PubMed:19819953). The transport activity of substrates L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) is much greater than that of 3,3',5-triiodo-L-thyronine (T3) (PubMed:12923172, PubMed:17667996, PubMed:19819953). The prehormone, T4, is the major form in the circulating blood and is converted to the active form, T3, by the iodothyronine-deiodinase in peripheral organs (PubMed:12923172). T3 plays an essential role in brain development via binding to specific nuclear receptors (thyroid hormone receptor) (PubMed:12923172). Also transports organic anions such as the conjugated steroid 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)) (PubMed:12923172, PubMed:17667996, PubMed:19819953). Transports T4 and estrone-3-sulfate in a pH-insensitive manner (By similarity). May serve as a drug efflux system at the blood brain barrier (PubMed:12923172, PubMed:17667996)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Prenatal exposure to monoclonal antibody brain-specific anion transporter-1 blocks brain-specific anion transporter-1 and limits T4 influx to the brain. This impairs the cognitive function in exposed progeny in the post-natal life., [RefSeq, PubMed]; The data demonstrate that OATP1c1 and MCT8 expression are regulated in a parallel manner during inflammation at the blood-brain barrier of rodents., [RefSeq, PubMed]; This study demonstrated that reduction of the Mct8 mRNA expression in hippocampus of thyroidectomized Wistar rats., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015125 bile acid transmembrane transporter activity;GO:0015349 thyroid hormone transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0055085 transmembrane transport;GO:0015721 bile acid and bile salt transport;GO:0043252 sodium-independent organic anion transport;GO:2000611 positive regulation of thyroid hormone generation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9EPZ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY94-1", "uniprot_id": [ { "id": "TIDC1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY94", "type": "external" } ], "mass": 32050.0, "length": 285, "protein_name": "Complex I assembly factor TIMMDC1, mitochondrial", "gene_name": "Timmdc1", "organism": "Rat", "refseq_name": "complex I assembly factor TIMMDC1, mitochondrial", "refseq_ac": [ { "id": "NP_001007677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007677", "type": "external" } ], "gene_names_uniprotkb": "Timmdc1", "gene_names_refseq": "RGD1359380; Timmdc1", "protein_names_uniprotkb": "Complex I assembly factor TIMMDC1, mitochondrial; TIMM domain containing protein 1; Translocase of inner mitochondrial membrane domain-containing protein 1", "protein_names_refseq": "TIMM domain containing-protein 1; complex I assembly factor TIMMDC1, mitochondrial; translocase of inner mitochondrial membrane domain-containing protein 1; transmembrane protein C3orf1 homolog-like; transmembrane protein C3orf1 homolog", "tax_id": 10116, "disease": "nuclear type mitochondrial complex I deficiency 31 (Disease Ontology:DOID:0112071)", "pathway": " (rno:303922); (R-RNO-6799198)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0016020 membrane", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY94-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXX1-1", "uniprot_id": [ { "id": "SLNL1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXX1", "type": "external" } ], "mass": 45960.0, "length": 414, "protein_name": "Schlafen-like protein 1", "gene_name": "Slfnl1", "organism": "Rat", "refseq_name": "schlafen-like protein 1", "refseq_ac": [ { "id": "NP_001019518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019518", "type": "external" } ], "gene_names_uniprotkb": "Slfnl1", "gene_names_refseq": "Slfnl1", "protein_names_uniprotkb": "Schlafen-like protein 1", "protein_names_refseq": "schlafen-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:500540)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25329797", "class_list": "", "function": "A key role for Slfn1 in the regulation of EPC biological behavior Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXX1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z136-1", "uniprot_id": [ { "id": "TSC1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z136", "type": "external" } ], "mass": 129022.0, "length": 1163, "protein_name": "Hamartin", "gene_name": "Tsc1", "organism": "Rat", "refseq_name": "hamartin", "refseq_ac": [ { "id": "NP_068626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068626", "type": "external" } ], "gene_names_uniprotkb": "Tsc1", "gene_names_refseq": "Tsc1", "protein_names_uniprotkb": "Hamartin; Tuberous sclerosis 1 protein homolog", "protein_names_refseq": "hamartin; tuberous sclerosis 1 protein homolog", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); spinal disease (Disease Ontology:DOID:0060564); anterior segment dysgenesis (Disease Ontology:DOID:0060648); tuberous sclerosis 1 (Disease Ontology:DOID:0080324); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); intellectual disability (Disease Ontology:DOID:1059); tuberous sclerosis (Disease Ontology:DOID:13515); breast cancer (Disease Ontology:DOID:1612); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); pleomorphic xanthoastrocytoma (Disease Ontology:DOID:4852); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:60445); (R-RNO-1632852); (R-RNO-165181); (R-RNO-380972); (R-RNO-5628897); (R-RNO-8854214)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "10029074;16707451;32739207;37020385;39169069;9809973", "class_list": "", "function": "MiR-27a-3p promotes inflammatory response in infectious endophthalmitis via targeting TSC1. Publication Status: Online-Only, [RefSeq, PubMed]; Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (By similarity). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (By similarity). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (By similarity). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (By similarity). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:16707451). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (PubMed:16707451). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (By similarity). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (By similarity). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (By similarity)., [UniProtKB, UniProtKB, PubMed]; Tuberous sclerosis 1 (Tsc1) mediated mTORC1 activation promotes glycolysis in tubular epithelial cells in kidney fibrosis., [RefSeq, PubMed]; Tuberous sclerosis complex-1 (TSC1) contributes to selective neuronal vulnerability in Alzheimer's disease., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0051879 Hsp90 protein binding;GO:0030544 Hsp70 protein binding;GO:0042030 ATPase inhibitor activity;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0033596 TSC1-TSC2 complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0036294 cellular response to decreased oxygen levels;GO:0007399 nervous system development;GO:0008285 negative regulation of cell population proliferation;GO:0008306 associative learning", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9Z136-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKR5-1", "uniprot_id": [ { "id": "ZDHC2_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKR5", "type": "external" } ], "mass": 42086.0, "length": 366, "protein_name": "Palmitoyltransferase ZDHHC2", "gene_name": "Zdhhc2", "organism": "Rat", "refseq_name": "palmitoyltransferase ZDHHC2", "refseq_ac": [ { "id": "NP_659564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659564", "type": "external" } ], "gene_names_uniprotkb": "Zdhhc2; Srec", "gene_names_refseq": "DHHC2; Zdhhc2; srec", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC2; 2.3.1.-; 2.3.1.225; Acyltransferase ZDHHC2; DHHC-2; Zinc finger DHHC domain-containing protein 2", "protein_names_refseq": "DHHC-2; acyltransferase ZDHHC2; membrane-associated DHHC2 zinc finger protein; palmitoyltransferase ZDHHC2; rec; small rec; zinc finger DHHC domain-containing protein 2; zinc finger DHHC-type palmitoyltransferase 2; zinc finger, DHHC domain containing 2; zinc finger, DHHC-type containing 2", "tax_id": 10116, "disease": "syndrome (Disease Ontology:DOID:225)", "pathway": " (rno:246326); (R-RNO-5683826)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19596852;21343290;25589740", "class_list": "", "function": "Knockdown of DHHC2 in rat hippocampal neurons disrupted exocytosis from recycling endosomes, enlargement of dendritic spines, AKAP recruitment to spines, and potentiation of AMPAR-mediated synaptic currents., [RefSeq, PubMed]; Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:19596852, PubMed:21343290, PubMed:25589740). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (PubMed:25589740). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (PubMed:19596852). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (PubMed:21343290). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function. Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane. Could also palmitoylate LCK and regulate its localization to the plasma membrane (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0P8F1", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity;GO:0019705 protein-cysteine S-myristoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098837 postsynaptic recycling endosome;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:1903539 protein localization to postsynaptic membrane;GO:0072659 protein localization to plasma membrane;GO:1900273 positive regulation of long-term synaptic potentiation;GO:0006612 protein targeting to membrane;GO:0022407 regulation of cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JKR5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DGF5-1", "uniprot_id": [ { "id": "ZDH12_RAT", "url": "https://www.uniprot.org/uniprot/Q6DGF5", "type": "external" } ], "mass": 31029.0, "length": 267, "protein_name": "Palmitoyltransferase ZDHHC12", "gene_name": "Zdhhc12", "organism": "Rat", "refseq_name": "palmitoyltransferase ZDHHC12", "refseq_ac": [ { "id": "NP_001013257", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013257", "type": "external" } ], "gene_names_uniprotkb": "Zdhhc12", "gene_names_refseq": "Zdhhc12", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC12; 2.3.1.225; DHHC domain-containing cysteine-rich protein 12; DHHC-12; Zinc finger DHHC domain-containing protein 12", "protein_names_refseq": "DHHC domain-containing cysteine-rich protein 12; DHHC-12; membrane-associated DHHC12 zinc finger protein; palmitoyltransferase ZDHHC12; probable palmitoyltransferase ZDHHC12; zinc finger DHHC domain-containing protein 12; zinc finger DHHC-type palmitoyltransferase 12; zinc finger, DHHC domain containing 12; zinc finger, DHHC-type containing 12", "tax_id": 10116, "disease": "", "pathway": " (rno:366014)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (By similarity). Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering. Thereby, indirectly regulates GABAergic synaptic transmission (By similarity). Negatively regulates NLRP3-driven inflammation. Catalyzes NLRP3 palmitoylation, leading to its degradation via the chaperone-mediated autophagy (CMA) process (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2TGJ7", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0043197 dendritic spine;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0097116 gephyrin clustering involved in postsynaptic density assembly;GO:0006612 protein targeting to membrane;GO:0032230 positive regulation of synaptic transmission, GABAergic;GO:0018230 peptidyl-L-cysteine S-palmitoylation;GO:1900226 negative regulation of NLRP3 inflammasome complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6DGF5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1R4-1", "uniprot_id": [ { "id": "TDRD7_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1R4", "type": "external" } ], "mass": 125310.0, "length": 1113, "protein_name": "Tudor domain-containing protein 7", "gene_name": "Tdrd7", "organism": "Rat", "refseq_name": "tudor domain-containing protein 7 isoform 1", "refseq_ac": [ { "id": "NP_620226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620226", "type": "external" } ], "gene_names_uniprotkb": "Tdrd7; Pctaire2bp", "gene_names_refseq": "Pctaire2bp; Tdrd7", "protein_names_uniprotkb": "Tudor domain-containing protein 7; PCTAIRE2-binding protein; Trap; Tudor repeat associator with PCTAIRE-2", "protein_names_refseq": "PCTAIRE2-binding protein; trap; tudor domain-containing protein 7 isoform 1; tudor domain-containing protein 7; tudor repeat associator with PCTAIRE-2", "tax_id": 10116, "disease": "cataract 36 (Disease Ontology:DOID:0110247)", "pathway": " (rno:85425)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10727952;22673903", "class_list": "", "function": "Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FVD0", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:1990904 ribonucleoprotein complex;GO:0033391 chromatoid body;GO:0035770 ribonucleoprotein granule", "go_biological_process": "GO:0030719 P granule organization;GO:0007283 spermatogenesis;GO:0010608 post-transcriptional regulation of gene expression;GO:0007281 germ cell development;GO:0034587 piRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9R1R4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1M3-1", "uniprot_id": [ { "id": "TSPY1_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1M3", "type": "external" } ], "mass": 37998.0, "length": 334, "protein_name": "Testis-specific Y-encoded protein 1", "gene_name": "Tspy1", "organism": "Rat", "refseq_name": "testis-specific Y-encoded protein 1", "refseq_ac": [ { "id": "NP_075212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075212", "type": "external" } ], "gene_names_uniprotkb": "Tspy1; Tspy", "gene_names_refseq": "Tspy1; Tspy", "protein_names_uniprotkb": "Testis-specific Y-encoded protein 1; rTSPY", "protein_names_refseq": "Testis specific protein on Y; rTSPY; testis-specific Y-encoded protein 1; testis-specific protein TSPY", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); seminoma (Disease Ontology:DOID:4440); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:25223)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10072602;16996029;22673903;9467017", "class_list": "", "function": "May be involved in sperm differentiation and proliferation., [UniProtKB, UniProtKB]; Rat Tspy may play critical roles as a histone chaperone during maturation of the elongating spermatids in the rat testis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70602;Q9R1M4", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006334 nucleosome assembly;GO:0007506 gonadal mesoderm development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9R1M3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYR9-1", "uniprot_id": [ { "id": "TSN1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYR9", "type": "external" } ], "mass": 26453.0, "length": 241, "protein_name": "Tetraspanin-1", "gene_name": "Tspan1", "organism": "Rat", "refseq_name": "tetraspanin-1", "refseq_ac": [ { "id": "NP_001004236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004236", "type": "external" } ], "gene_names_uniprotkb": "Tspan1", "gene_names_refseq": "Tspan1", "protein_names_uniprotkb": "Tetraspanin-1; Tspan-1", "protein_names_refseq": "tetraspan 1; tetraspanin-1; tspan-1", "tax_id": 10116, "disease": "", "pathway": " (rno:298436)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31440771", "class_list": "", "function": "Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (By similarity). Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways (PubMed:31440771). Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK. Also promotes the stability of the thiamine transporter 1/SLC19A2 in intestinal epithelial cells leading to an increase of thiamine uptake process (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; This study identified Tetraspanin 1 (Tspan1) as a critical regulator of TrkA signaling and neuronal differentiation induced by nerve growth factor., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYR9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76IC6-1", "uniprot_id": [ { "id": "ZDH23_RAT", "url": "https://www.uniprot.org/uniprot/Q76IC6", "type": "external" } ], "mass": 48473.0, "length": 429, "protein_name": "Palmitoyltransferase ZDHHC23", "gene_name": "Zdhhc23", "organism": "Rat", "refseq_name": "palmitoyltransferase ZDHHC23", "refseq_ac": [ { "id": "NP_998792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998792", "type": "external" } ], "gene_names_uniprotkb": "Zdhhc23; Nidd", "gene_names_refseq": "DHHC23; Zdhhc23; nidd", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC23; 2.3.1.225; DHHC-23; NNOS-interacting DHHC domain-containing protein with dendritic mRNA; Zinc finger DHHC domain-containing protein 23; zDHHC23", "protein_names_refseq": "DHHC-23; NNOS-interacting DHHC domain-containing protein with dendritic mRNA; membrane-associated DHHC23 zinc finger protein; nNOS-intereacting DHHC-containing Dem protein-L; palmitoyltransferase ZDHHC23; probable palmitoyltransferase ZDHHC23; zinc finger DHHC domain-containing protein 23; zinc finger DHHC-type palmitoyltransferase 23; zinc finger, DHHC domain containing 23; zinc finger, DHHC-type containing 23", "tax_id": 10116, "disease": "", "pathway": " (rno:363783)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15105416;17873365;17899403", "class_list": "", "function": "NIDD gene expression may be involved in the different pathological conditions including nerve regeneration, neuron loss or survival, and even pain processes., [RefSeq, PubMed]; NIDD mRNA was predominantly expressed in nociceptive neurons and in neurons of the spinal dorsal horn and the number of NIDD-positive neurons in the corresponding dorsal root ganglia or spinal cord increased following induction of chronic hyperalgesia., [RefSeq, PubMed]; Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (Probable). Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane (By similarity). May be involved in NOS1 regulation and targeting to the synaptic membrane (PubMed:15105416)., [UniProtKB, UniProtKB, PubMed]; These results suggest that NIDD plays an important role in the regulation of the nitric oxide signaling pathway at postsynaptic sites through targeting of nueronal nitric oxide synthase to the postsynaptic membrane., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2TGI7", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006612 protein targeting to membrane;GO:0018345 protein palmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q76IC6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JSN6-1", "uniprot_id": [ { "id": "A0A0G2JSN6_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JSN6", "type": "external" } ], "mass": 60855.0, "length": 547, "protein_name": "Adhesion G protein-coupled receptor G3", "gene_name": "Adgrg3", "organism": "Rat", "refseq_name": "probable G-protein coupled receptor 97 precursor", "refseq_ac": [ { "id": "NP_001417145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001417145", "type": "external" } ], "gene_names_uniprotkb": "Adgrg3", "gene_names_refseq": "Adgrg3; Gpr97", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor G3; G-protein coupled receptor 97", "protein_names_refseq": "G protein-coupled receptor 97; probable G-protein coupled receptor 97 precursor; probable G-protein coupled receptor 97", "tax_id": 10116, "disease": "", "pathway": " (rno:291854); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0030183 B cell differentiation;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JSN6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JU91-1", "uniprot_id": [ { "id": "A0A0G2JU91_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JU91", "type": "external" } ], "mass": 277616.0, "length": 2546, "protein_name": "Nuclear receptor corepressor 2", "gene_name": "Ncor2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ncor2", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear receptor corepressor 2; Silencing mediator of retinoic acid and thyroid hormone receptor; T3 receptor-associating factor; Thyroid-, retinoic-acid-receptor-associated corepressor", "protein_names_refseq": "", "tax_id": 10116, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); breast cancer (Disease Ontology:DOID:1612); endometrial carcinoma (Disease Ontology:DOID:2871); myelofibrosis (Disease Ontology:DOID:4971); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (R-RNO-2173795); (R-RNO-3214815); (R-RNO-350054); (R-RNO-381340); (R-RNO-383280); (R-RNO-400206); (R-RNO-9029569); (R-RNO-9623433); (R-RNO-9707564); (R-RNO-9841922)", "pathway_count": 10, "publication_count": 2, "publication_id_list": "16641100;22673903", "class_list": "", "function": "Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3. Required to activate the histone deacetylase activity of HDAC3. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008047 enzyme activator activity;GO:0003714 transcription corepressor activity;GO:0035259 nuclear glucocorticoid receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0032991 protein-containing complex;GO:0005634 nucleus;GO:0017053 transcription repressor complex;GO:0016604 nuclear body", "go_biological_process": "GO:0010565 regulation of ketone metabolic process;GO:0060816 random inactivation of X chromosome;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0G2JU91-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JU15-1", "uniprot_id": [ { "id": "A0A0G2JU15_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JU15", "type": "external" } ], "mass": 78334.0, "length": 690, "protein_name": "Small ribosomal subunit protein mS39", "gene_name": "Ptcd3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ptcd3", "gene_names_refseq": "", "protein_names_uniprotkb": "Small ribosomal subunit protein mS39; 28S ribosomal protein S39, mitochondrial; Pentatricopeptide repeat domain-containing protein 3, mitochondrial", "protein_names_refseq": "", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency 51 (Disease Ontology:DOID:0112137)", "pathway": " (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial RNA-binding protein that has a role in mitochondrial translation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043024 ribosomal small subunit binding;GO:0019843 rRNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006417 regulation of translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JU15-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JUC9-1", "uniprot_id": [ { "id": "A0A0G2JUC9_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JUC9", "type": "external" } ], "mass": 527477.0, "length": 4836, "protein_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "Herc2", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": [ { "id": "XP_006229362", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006229362", "type": "external" } ], "gene_names_uniprotkb": "Herc2", "gene_names_refseq": "Herc2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HERC2; 2.3.2.26; HECT domain and RCC1-like domain-containing protein 2; HECT-type E3 ubiquitin transferase HERC2", "protein_names_refseq": "E3 ubiquitin-protein ligase HERC2; hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2; hect domain and RLD 2; probable E3 ubiquitin-protein ligase HERC2", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 38 (Disease Ontology:DOID:0081203); pigmentation disease (Disease Ontology:DOID:10123)", "pathway": " (R-RNO-3108214); (R-RNO-5693565); (R-RNO-5693571); (R-RNO-5693607); (R-RNO-69473); (R-RNO-983168)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Also modulates iron metabolism by regulating the basal turnover of FBXL5., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031625 ubiquitin protein ligase binding;GO:0032183 SUMO binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005814 centriole;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006281 DNA repair;GO:0016567 protein ubiquitination;GO:0007283 spermatogenesis;GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JUC9-1", "record_type": "protein", "filter_code": "0000000.0000111.000100.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JXY3-1", "uniprot_id": [ { "id": "A0A0G2JXY3_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JXY3", "type": "external" } ], "mass": 45145.0, "length": 414, "protein_name": "Apolipoprotein L 7a like 1", "gene_name": "Apol7al1; Apol7a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Apol7al1; Apol7a; Apol7a-Apol9; Apol7a; Apol7b; Apol9a-Apol7a; LOC133667826", "gene_names_refseq": "", "protein_names_uniprotkb": "Apolipoprotein L 7a like 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "substance abuse (Disease Ontology:DOID:302); schizophrenia (Disease Ontology:DOID:5419); kidney disease (Disease Ontology:DOID:557)", "pathway": " (R-RNO-2168880); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006869 lipid transport;GO:0042157 lipoprotein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JXY3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JXL5-1", "uniprot_id": [ { "id": "A0A0G2JXL5_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JXL5", "type": "external" } ], "mass": 726599.0, "length": 7415, "protein_name": "Mucin 19, oligomeric", "gene_name": "Muc19; Smgc", "organism": "Rat", "refseq_name": "mucin-19 precursor", "refseq_ac": [ { "id": "NP_001296418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296418", "type": "external" } ], "gene_names_uniprotkb": "Muc19; Smgc; AC096792.1; Muc19; Smgc", "gene_names_refseq": "Muc19l1; Muc19; RGD1624205; SMGC", "protein_names_uniprotkb": "Mucin 19, oligomeric", "protein_names_refseq": "mucin 19-like 1; mucin apoprotein; mucin-19 precursor; mucin-19", "tax_id": 10116, "disease": "Sjogren's syndrome (Disease Ontology:DOID:12894)", "pathway": " (rno:446171); (R-RNO-913709); (R-RNO-977068)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 10, "predicted_n_glycosites": 0, "predicted_o_glycosites": 10, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046848 hydroxyapatite binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0045087 innate immune response;GO:0070098 chemokine-mediated signaling pathway;GO:0030324 lung development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JXL5-1", "record_type": "protein", "filter_code": "0000000.1000011.000100.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JV05-1", "uniprot_id": [ { "id": "A0A0G2JV05_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JV05", "type": "external" } ], "mass": 182042.0, "length": 1641, "protein_name": "Maestro heat-like repeat family member 1", "gene_name": "Mroh1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mroh1", "gene_names_refseq": "", "protein_names_uniprotkb": "Maestro heat-like repeat family member 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:100125385)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, 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"GO:0170064 lysosome fission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JV05-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JW34-1", "uniprot_id": [ { "id": "A0A0G2JW34_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JW34", "type": "external" } ], "mass": 14379.0, "length": 127, "protein_name": "CDGSH iron sulfur domain 3", "gene_name": "Cisd3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cisd3", "gene_names_refseq": "", "protein_names_uniprotkb": "CDGSH iron sulfur domain 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:287661)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, 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"ec_number_list": [], "go_molecular_function": "GO:0051537 2 iron, 2 sulfur cluster binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005737 cytoplasm", "go_biological_process": "GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JW34-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924U1-1", "uniprot_id": [ { "id": "KISSR_RAT", "url": "https://www.uniprot.org/uniprot/Q924U1", "type": "external" } ], "mass": 42889.0, "length": 396, "protein_name": "KiSS-1 receptor", "gene_name": "Kiss1r", "organism": "Rat", "refseq_name": "kiSS-1 receptor isoform 1", "refseq_ac": [ { "id": "NP_076482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076482", "type": "external" } ], "gene_names_uniprotkb": "Kiss1r; Gpr54", "gene_names_refseq": "Gpr54; Kiss1r", "protein_names_uniprotkb": "KiSS-1 receptor; G protein-coupled receptor 54; G protein-coupled receptor OT7T175; KiSS-1R; Kisspeptins receptor; Metastin receptor; rOT7T175", "protein_names_refseq": "G protein-coupled receptor 54; G-protein coupled receptor OT7T175; kiSS-1 receptor isoform 1; kiSS-1 receptor; kiSS-1R; kisspeptins receptor; metastin receptor; orphan G protein-coupled receptor GPR54; rOT7T175", "tax_id": 10116, "disease": "hypogonadotropic hypogonadism 8 with or without anosmia (Disease Ontology:DOID:0090074); central precocious puberty 1 (Disease Ontology:DOID:0112310); breast cancer (Disease Ontology:DOID:1612); hypogonadism (Disease Ontology:DOID:1924); transitional cell carcinoma (Disease Ontology:DOID:2671); papillary carcinoma (Disease Ontology:DOID:3113)", "pathway": " (rno:78976); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10100623;11385580;11457843;15157736;15219839;15242985;15375028;15486019;15500545;15593369;15637288;15665556;31724927;35180577;35718292;36094166;37614139", "class_list": "", "function": "DNA hypermethylation of Kiss1r promoter and reduction of hepatic Kiss1r in female rats with type 2 diabetes., [RefSeq, PubMed]; Effects of Ovarian Transplant on Anti-Mullerian Hormone, Kisspeptin-1, and Kisspeptin-1 Receptor Levels in Rats., [RefSeq, PubMed]; Maternal hypothyroidism reduces the expression of the kisspeptin/Kiss1r system in the maternal-fetal interface of rats., [RefSeq, PubMed]; Receptor for kisspeptins (kisspeptin-10, kisspeptin-13, kisspeptin-14 and metastin/kisspeptin-54) (PubMed:11457843). The hypothalamic KISS1/KISS1R signaling system plays a central role in the regulation of the hypothalamic-pituitary-gonadal reproductive axis by modulating the secretion of gonadotropin-releasing hormone (GnRH) from GnRH neurons (PubMed:15219839, PubMed:15242985, PubMed:15375028, PubMed:15486019, PubMed:15500545, PubMed:15637288, PubMed:15665556). In these neurons, kisspeptin binding to its receptor activates G(q)-dependent signaling, leading to phospholipase C (PLC) activation, and hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2). The subsequent rise in intracellular calcium levels results in the inhibition of inward rectifier potassium channels and activation of TRPC-like cation channels, leading to GnRH neurons depolarization and stimulation (By similarity). In addition to this pathway, kisspeptin also triggers G(q)-independent signaling via beta-arrestin, leading to MAPK cascade activation and ERK1/ERK2 phosphorylation (By similarity). In bone tissue, activation of KISS1R by kisspeptin-10 recruits phosphatase DUSP18 and SRC to the KISS1R C-terminus through a G(q)-dependent signaling pathway. This leads to DUSP18-mediated dephosphorylation of SRC, down-regulation of osteoclast differentiation and activity, and consequently suppression of bone resorption (By similarity). KISS1R is also involved in the regulation of other processes, including cell proliferation and cell migration (PubMed:11457843)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Sex-specific hypothalamic expression of kisspeptin, gonadotropin releasing hormone, and kisspeptin receptor in progressive demyelination model., [RefSeq, PubMed]; [Effects of electroacupuncture on the secretion function of ovarian cells and kisspeptin/kiss1r system in rats with polycystic ovarian syndrome]., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, 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membrane;GO:0005929 cilium;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q924U1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNL4-1", "uniprot_id": [ { "id": "STK40_RAT", "url": "https://www.uniprot.org/uniprot/Q7TNL4", "type": "external" } ], "mass": 48960.0, "length": 435, "protein_name": "Serine/threonine-protein kinase 40", "gene_name": "Stk40", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase 40", "refseq_ac": [ { "id": "NP_898879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898879", "type": "external" } ], "gene_names_uniprotkb": "Stk40; Lyk4", "gene_names_refseq": "Lyk4; RGD1307310; Stk40", "protein_names_uniprotkb": "Serine/threonine-protein kinase 40; 2.7.11.1; Serine/threonine-protein kinase lyk4", "protein_names_refseq": "Ser/Thr-like protein kinase lyk4; serine/threonine-protein kinase 40; serine/threonine-protein kinase lyk4", "tax_id": 10116, "disease": "", "pathway": " (rno:360230)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be a negative regulator of NF-kappa-B and p53-mediated gene transcription., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, 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"https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0003016 respiratory system process;GO:0043066 negative regulation of apoptotic process;GO:0048286 lung alveolus development;GO:0005977 glycogen metabolic process;GO:0030324 lung development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7TNL4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGV7-1", "uniprot_id": [ { "id": "THTPA_RAT", "url": "https://www.uniprot.org/uniprot/Q8CGV7", "type": "external" } ], "mass": 24544.0, "length": 224, "protein_name": "Thiamine-triphosphatase", "gene_name": "Thtpa", "organism": "Rat", "refseq_name": "thiamine-triphosphatase", "refseq_ac": [ { "id": "NP_001007683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007683", "type": "external" } ], "gene_names_uniprotkb": "Thtpa", "gene_names_refseq": "Thtpa", "protein_names_uniprotkb": "Thiamine-triphosphatase; 3.6.1.28; ThTPase", "protein_names_refseq": "thTPase; thiamine-triphosphatase", "tax_id": 10116, "disease": "", "pathway": " (rno:305889); (R-RNO-196819)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolase highly specific for thiamine triphosphate (ThTP)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.28", "type": "external" } ], "go_molecular_function": "GO:0050333 thiamine triphosphate phosphatase activity;GO:0000287 magnesium ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0016311 dephosphorylation;GO:0042357 thiamine diphosphate metabolic process;GO:0009229 thiamine diphosphate biosynthetic process;GO:0006772 thiamine metabolic process;GO:0006796 phosphate-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CGV7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHF0-1", "uniprot_id": [ { "id": "MARK3_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHF0", "type": "external" } ], "mass": 88751.0, "length": 797, "protein_name": "MAP/microtubule affinity-regulating kinase 3", "gene_name": "Mark3", "organism": "Rat", "refseq_name": "MAP/microtubule affinity-regulating kinase 3", "refseq_ac": [ { "id": "NP_570105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570105", "type": "external" } ], "gene_names_uniprotkb": "Mark3", "gene_names_refseq": "Mark3", "protein_names_uniprotkb": "MAP/microtubule affinity-regulating kinase 3; 2.7.11.1", "protein_names_refseq": "MAP/microtubule affinity-regulating kinase 3", "tax_id": 10116, "disease": "visual impairment and progressive phthisis bulbi (Disease Ontology:DOID:0070356); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:170577); (R-RNO-5673000); (R-RNO-5674135); (R-RNO-5675221); (R-RNO-9856649)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "22673903;38843836", "class_list": "", "function": "May play a role in sperm motility, especially in the regulation of flagellar function., [UniProtKB, UniProtKB, UniProtKB]; Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity;GO:0019903 protein phosphatase binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0042995 cell projection", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:1900181 negative regulation of protein localization to nucleus;GO:0001764 neuron migration;GO:0010389 regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VHF0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Y53-1", "uniprot_id": [ { "id": "TDIF1_RAT", "url": "https://www.uniprot.org/uniprot/Q91Y53", "type": "external" } ], "mass": 36692.0, "length": 327, "protein_name": "Deoxynucleotidyltransferase terminal-interacting protein 1", "gene_name": "Dnttip1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dnttip1; Tdif1", "gene_names_refseq": "", "protein_names_uniprotkb": "Deoxynucleotidyltransferase terminal-interacting protein 1; TdIF1; TdT-interacting factor 1; Terminal deoxynucleotidyltransferase-interacting factor 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-9764725)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042803 protein homodimerization activity;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005694 chromosome;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q91Y53-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQN5-1", "uniprot_id": [ { "id": "SMBP2_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQN5", "type": "external" } ], "mass": 108440.0, "length": 988, "protein_name": "DNA-binding protein SMUBP-2", "gene_name": "Ighmbp2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighmbp2; Smbp2", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA-binding protein SMUBP-2; 5.6.2.3; 5.6.2.5; AEP; ATP-dependent helicase IGHMBP2; Antifreeze enhancer-binding protein ortholog; DNA and RNA 5'-3' helicase IGHMBP2", "protein_names_refseq": "", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease axonal type 2S (Disease Ontology:DOID:0110171); autosomal recessive distal hereditary motor neuronopathy 1 (Disease Ontology:DOID:0111064)", "pathway": " (rno:29532)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11106437", "class_list": "", "function": "5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction (By similarity). Specific to 5'-phosphorylated single-stranded guanine-rich sequences (By similarity). May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (By similarity). May play a role in regulation of transcription (PubMed:11106437). Interacts with tRNA-Tyr (By similarity)., [UniProtKB, PubMed, UniProtKB]; 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction. Specific to 5'-phosphorylated single-stranded guanine-rich sequences. May play a role in RNA metabolism, ribosome biogenesis or initiation of translation. May play a role in regulation of transcription. Interacts with tRNA-Tyr., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:1990955 G-rich single-stranded DNA binding;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0050905 neuromuscular process;GO:0006974 DNA damage response;GO:0021522 spinal cord motor neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9EQN5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R095-1", "uniprot_id": [ { "id": "SPEF2_RAT", "url": "https://www.uniprot.org/uniprot/Q9R095", "type": "external" } ], "mass": 208159.0, "length": 1801, "protein_name": "Sperm flagella and cilia-associated protein 2", "gene_name": "Spef2", "organism": "Rat", "refseq_name": "sperm flagellar protein 2 isoform 3", "refseq_ac": [ { "id": "NP_001401938", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401938", "type": "external" } ], "gene_names_uniprotkb": "Spef2; Kpl2", "gene_names_refseq": "Kpl2; Spef2", "protein_names_uniprotkb": "Sperm flagella and cilia-associated protein 2; Protein KPL2; Sperm flagellar protein 2", "protein_names_refseq": "sperm flagellar 2; sperm flagellar protein 2 isoform 3; sperm flagellar protein 2-like; sperm flagellar protein 2", "tax_id": 10116, "disease": "spermatogenic failure 43 (Disease Ontology:DOID:0111917); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (rno:64555)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10100999;22673903", "class_list": "", "function": "Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Plays a role in bone growth where it seems to be required for normal osteoblast differentiation. Required for normal beat frequency of tracheal epithelial cilia and oviduct cilia., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q4V8M1", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005929 cilium;GO:0036126 sperm flagellum", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0007283 spermatogenesis;GO:0048705 skeletal system morphogenesis;GO:0044458 motile cilium assembly;GO:0048854 brain morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9R095-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYS6-1", "uniprot_id": [ { "id": "SNX17_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYS6", "type": "external" } ], "mass": 52882.0, "length": 470, "protein_name": "Sorting nexin-17", "gene_name": "Snx17", "organism": "Rat", "refseq_name": "sorting nexin-17", "refseq_ac": [ { "id": "NP_001011981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011981", "type": "external" } ], "gene_names_uniprotkb": "Snx17", "gene_names_refseq": "Snx17", "protein_names_uniprotkb": "Sorting nexin-17", "protein_names_refseq": "sorting nexin-17", "tax_id": 10116, "disease": "", "pathway": " (rno:298836)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;29393594;30025651", "class_list": "", "function": "Abnormal down-regulation of SNX17 contributes to ischemic damages of cardiac electrophysiology and contractile function., [RefSeq, PubMed]; Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P))., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050750 low-density lipoprotein particle receptor binding;GO:0035091 phosphatidylinositol binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007165 signal transduction;GO:0001822 kidney development;GO:0006898 receptor-mediated endocytosis;GO:0035904 aorta development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6AYS6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTY8-1", "uniprot_id": [ { "id": "ZBT10_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTY8", "type": "external" } ], "mass": 91698.0, "length": 836, "protein_name": "Zinc finger and BTB domain-containing protein 10", "gene_name": "Zbtb10", "organism": "Rat", "refseq_name": "zinc finger and BTB domain-containing protein 10", "refseq_ac": [ { "id": "NP_077815", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077815", "type": "external" } ], "gene_names_uniprotkb": "Zbtb10; Rinzf", "gene_names_refseq": "Rinzf; Zbtb10; ania-11", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 10; Zinc finger protein RIN ZF", "protein_names_refseq": "zinc finger and BTB domain-containing protein 10; zinc finger protein RIN ZF", "tax_id": 10116, "disease": "", "pathway": " (rno:80338)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10075714", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042162 telomeric DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9WTY8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925B3-1", "uniprot_id": [ { "id": "TRPM7_RAT", "url": "https://www.uniprot.org/uniprot/Q925B3", "type": "external" } ], "mass": 212422.0, "length": 1862, "protein_name": "Transient receptor potential cation channel subfamily M member 7", "gene_name": "Trpm7", "organism": "Rat", "refseq_name": "transient receptor potential cation channel subfamily M member 7", "refseq_ac": [ { "id": "NP_446157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446157", "type": "external" } ], "gene_names_uniprotkb": "Trpm7", "gene_names_refseq": "Chak; LTrpC-7; Ltrpc7; Trp-plik; Trpm7", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily M member 7; 2.7.11.1; LTrpC-7; LTrpC7; Long transient receptor potential channel 7; TRP-PLIK; Transient receptor potential-phospholipase C-interacting kinase", "protein_names_refseq": "long transient receptor potential channel 7; transient receptor potential cation channel subfamily M member 7; transient receptor potential-phospholipase C-interacting kinase", "tax_id": 10116, "disease": "sinoatrial node disease (Disease Ontology:DOID:0050824); MASA syndrome (Disease Ontology:DOID:0060246); chromosome 15q13.3 microdeletion syndrome (Disease Ontology:DOID:0060394); amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (Disease Ontology:DOID:0111246)", "pathway": " (rno:679906); (R-RNO-3295583)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11161216;11941371;12904301;15591230;18782578;36794562;36869357;37653221;38180616;38581988", "class_list": "", "function": "Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx. Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation. The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7. TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways (By similarity). In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Conditional knockout of transient receptor potential melastatin 7 in the enamel epithelium: Effects on enamel formation., [RefSeq, PubMed]; Data show that receptor-mediated activation of phospholipase C results in the hydrolysis of localized PIP(2), leading to inactivation of the TRPM7 channel., [RefSeq, PubMed]; Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis. Erratum:[Biol Res. 2023 May 11;56(1):24. doi: 10.1186/s40659-023-00433-6. PMID: 37165417] Publication Status: Online-Only, [RefSeq, PubMed]; TRPM7 Mediates BSCB Disruption After Spinal Cord Injury by Regulating the mTOR/JMJD3 Axis in Rats., [RefSeq, PubMed]; TRPM7 Mediates Neuropathic Pain by Activating mTOR Signaling in Astrocytes after Spinal Cord Injury in Rats., [RefSeq, PubMed]; TRPM7 currents were identified in the rat brain microglia, [RefSeq, PubMed]; TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCalpha-HuR axis in rheumatoid arthritis., [RefSeq, PubMed]; TRPM7 is a functionally important regulator of Mg2+ homeostasis and growth in vascular smooth muscle cells., [RefSeq, PubMed]; The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development., [UniProtKB, UniProtKB]; The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 43, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8I6AVX9;A6HPZ2;A7L642", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0003779 actin binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005262 calcium channel activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0031410 cytoplasmic vesicle;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0015693 magnesium ion transport;GO:0006829 zinc ion transport;GO:1903830 magnesium ion transmembrane transport;GO:0006468 protein phosphorylation;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q925B3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYE4-1", "uniprot_id": [ { "id": "VATC2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYE4", "type": "external" } ], "mass": 48243.0, "length": 425, "protein_name": "V-type proton ATPase subunit C 2", "gene_name": "Atp6v1c2", "organism": "Rat", "refseq_name": "V-type proton ATPase subunit C 2", "refseq_ac": [ { "id": "NP_001014221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014221", "type": "external" } ], "gene_names_uniprotkb": "Atp6v1c2", "gene_names_refseq": "Atp6v1c2", "protein_names_uniprotkb": "V-type proton ATPase subunit C 2; V-ATPase subunit C 2; Vacuolar proton pump subunit C 2", "protein_names_refseq": "ATPase, H+ transporting, V1 subunit C; ATPase, H+ transporting, lysosomal V1 subunit C2; V-ATPase subunit C 2; V-type proton ATPase subunit C 2; vacuolar H+ ATPase C2; vacuolar proton pump subunit C 2", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:362802); (R-RNO-1222556); (R-RNO-77387); (R-RNO-917977); (R-RNO-9639288); (R-RNO-983712)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "16283434", "class_list": "", "function": "Analysis of V-type ATPase C subunit gene, Atp6v1c2, during culture of rat lung type II pneumocytes, [RefSeq, PubMed]; Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53B80", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0033180 proton-transporting V-type ATPase, V1 domain", "go_biological_process": "GO:0030177 positive regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYE4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVC0-1", "uniprot_id": [ { "id": "SEPT7_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVC0", "type": "external" } ], "mass": 50508.0, "length": 436, "protein_name": "Septin-7", "gene_name": "Septin7", "organism": "Rat", "refseq_name": "septin-7 isoform a", "refseq_ac": [ { "id": "NP_072138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072138", "type": "external" } ], "gene_names_uniprotkb": "Septin7; Cdc10; Sept7", "gene_names_refseq": "Cdc10; Sept7; Septin7", "protein_names_uniprotkb": "Septin-7; CDC10 protein homolog", "protein_names_refseq": "CDC10 (cell division cycle 10, S.cerevisiae, homolog); CDC10 protein homolog; septin-7 isoform a", "tax_id": 10116, "disease": "", "pathway": " (rno:64551); (R-RNO-5687128)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15485874;18683930;22673903;25494357", "class_list": "", "function": "Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Sept7/9b/11 form a complex that has effects on filament elongation, bundling, or disruption., [RefSeq, PubMed]; Show that diffusion of receptors and bulk membrane, but not cytoplasmic proteins, is slower in spines bearing Sept7 at their neck. Finally, when Sept7 expression was suppressed by RNA interference, membrane molecules explored larger membrane areas. Our findings indicate that Sept7 regulates membrane protein access to spines Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0099186 structural constituent of postsynapse", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0097227 sperm annulus;GO:0032156 septin cytoskeleton;GO:0005940 septin ring;GO:0005634 nucleus", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007010 cytoskeleton organization;GO:0048668 collateral sprouting;GO:0060271 cilium assembly;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WVC0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSP2-1", "uniprot_id": [ { "id": "KIF15_RAT", "url": "https://www.uniprot.org/uniprot/Q7TSP2", "type": "external" } ], "mass": 159540.0, "length": 1385, "protein_name": "Kinesin-like protein KIF15", "gene_name": "Kif15", "organism": "Rat", "refseq_name": "kinesin-like protein KIF15", "refseq_ac": [ { "id": "NP_853666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_853666", "type": "external" } ], "gene_names_uniprotkb": "Kif15; Klp2", "gene_names_refseq": "Kif15; Knsl7", "protein_names_uniprotkb": "Kinesin-like protein KIF15; Kinesin-like protein 2", "protein_names_refseq": "kinesin-like 7; kinesin-like protein 2; kinesin-like protein KIF15", "tax_id": 10116, "disease": "", "pathway": " (rno:353302); (R-RNO-2132295); (R-RNO-6811434); (R-RNO-983189)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "14618103;21048148;27170353;33453102", "class_list": "", "function": "KIF15 supports spermatogenesis via its effects on Sertoli cell microtubule, actin, vimentin, and septin cytoskeletons., [RefSeq, PubMed]; Kinesin-12 depletion from cultured rat cortical astrocytes decreases cell proliferation but increases migration., [RefSeq, PubMed]; Kinesin-12 shares functions with kinesin-5 related to microtubule-microtubule interactions, but kinesin-12 has other functions not shared by kinesin-5 that are related to the ability of kinesin-12 to interact with actin., [RefSeq, PubMed]; Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TN17", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity;GO:0008574 plus-end-directed microtubule motor activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0090307 mitotic spindle assembly;GO:0007018 microtubule-based movement;GO:0051299 centrosome separation;GO:0000278 mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TSP2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYP3-1", "uniprot_id": [ { "id": "TTC29_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYP3", "type": "external" } ], "mass": 54476.0, "length": 471, "protein_name": "Tetratricopeptide repeat protein 29", "gene_name": "Ttc29", "organism": "Rat", "refseq_name": "tetratricopeptide repeat protein 29", "refseq_ac": [ { "id": "NP_001013912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013912", "type": "external" } ], "gene_names_uniprotkb": "Ttc29", "gene_names_refseq": "Ttc29", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 29; TPR repeat protein 29", "protein_names_refseq": "TPR repeat protein 29; tetratricopeptide repeat protein 29", "tax_id": 10116, "disease": "spermatogenic failure 42 (Disease Ontology:DOID:0111923)", "pathway": " (rno:291944)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Axonemal protein which is implicated in axonemal and/or peri-axonemal structure assembly and regulates flagellum assembly and beating and therefore sperm motility., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0097228 sperm principal piece;GO:0005737 cytoplasm", "go_biological_process": "GO:0003341 cilium movement;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYP3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6W3-1", "uniprot_id": [ { "id": "HDAC3_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6W3", "type": "external" } ], "mass": 48821.0, "length": 428, "protein_name": "Histone deacetylase 3", "gene_name": "Hdac3", "organism": "Rat", "refseq_name": "histone deacetylase 3", "refseq_ac": [ { "id": "NP_445900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445900", "type": "external" } ], "gene_names_uniprotkb": "Hdac3", "gene_names_refseq": "Hdac3", "protein_names_uniprotkb": "Histone deacetylase 3; 3.5.1.-; 3.5.1.98; HD3; Protein deacetylase HDAC3; Protein deacylase HDAC3", "protein_names_refseq": "HD3; histone deacetylase 3; histone deacetylase subfamily 1; protein deacetylase HDAC3; protein deacylase HDAC3", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); intrahepatic cholestasis of pregnancy (Disease Ontology:DOID:0070227); prostate carcinoma (Disease Ontology:DOID:10286); impotence (Disease Ontology:DOID:1875); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); endometriosis (Disease Ontology:DOID:289); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:84578); (R-RNO-3214815); (R-RNO-350054); (R-RNO-381340); (R-RNO-400206); (R-RNO-9029569); (R-RNO-9701898); (R-RNO-9707564); (R-RNO-9841922)", "pathway_count": 9, "publication_count": 6, "publication_id_list": "16033423;22673903;33932446;34971719;35025700;36201274", "class_list": "", "function": "Depleted HDAC3 attenuates hyperuricemia-induced renal interstitial fibrosis via miR-19b-3p/SF3B3 axis., [RefSeq, PubMed]; Depleted histone deacetylase 3 or restored microRNA-19b-1-5p facilitates recovery of spinal cord injury via inactivating JAK2/STAT3 signaling pathway., [RefSeq, PubMed]; HDAC3 Impairs Cardiac Function in Chronic Heart Failure Rats via Mediating MicroRNA-26b-3p to Target High Mobility Group AT-Hook 2., [RefSeq, PubMed]; Histone deacetylase 3 suppresses the expression of SHP-1 via deacetylation of DNMT1 to promote heart failure., [RefSeq, PubMed]; Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99PA0", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "3.5.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.48", "type": "external" }, { "id": "3.5.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.62", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0060816 random inactivation of X chromosome;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0001934 positive regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6P6W3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKU6-1", "uniprot_id": [ { "id": "STRBP_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKU6", "type": "external" } ], "mass": 74005.0, "length": 671, "protein_name": "Spermatid perinuclear RNA-binding protein", "gene_name": "Strbp", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Strbp", "gene_names_refseq": "", "protein_names_uniprotkb": "Spermatid perinuclear RNA-binding protein; 74 kDa double-stranded RNA-binding protein; p74", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:84476)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10684936", "class_list": "", "function": "Involved in spermatogenesis and sperm function (By similarity). Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Also binds to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity)., [UniProtKB, PubMed]; Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Also binds to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008017 microtubule binding;GO:0003725 double-stranded RNA binding;GO:0003727 single-stranded RNA binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0015630 microtubule cytoskeleton;GO:0002177 manchette", "go_biological_process": "GO:0007638 mechanosensory behavior;GO:0007286 spermatid development;GO:0048870 cell motility;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JKU6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Z36-1", "uniprot_id": [ { "id": "ZHX3_RAT", "url": "https://www.uniprot.org/uniprot/Q80Z36", "type": "external" } ], "mass": 103783.0, "length": 951, "protein_name": "Zinc fingers and homeoboxes protein 3", "gene_name": "Zhx3", "organism": "Rat", "refseq_name": "zinc fingers and homeoboxes protein 3", "refseq_ac": [ { "id": "NP_001040562", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040562", "type": "external" } ], "gene_names_uniprotkb": "Zhx3", "gene_names_refseq": "Tix1; Zhx3", "protein_names_uniprotkb": "Zinc fingers and homeoboxes protein 3; Zinc finger and homeodomain protein 3", "protein_names_refseq": "triple homeobox 1; zinc finger and homeodomain protein 3; zinc fingers and homeoboxes protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:311604)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12659632;17056598;29393594", "class_list": "", "function": "Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA., [UniProtKB, PubMed, UniProtKB, UniProtKB]; ZHX proteins 1, 2 and 3 are major transcriptional mediators of podocyte disease Erratum:[J Biol Chem. 2007 Apr 27;282(17):13140], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1I1B1", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80Z36-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYK5-1", "uniprot_id": [ { "id": "LYAR_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYK5", "type": "external" } ], "mass": 43680.0, "length": 386, "protein_name": "Cell growth-regulating nucleolar protein", "gene_name": "Lyar", "organism": "Rat", "refseq_name": "cell growth-regulating nucleolar protein isoform 1", "refseq_ac": [ { "id": "NP_001011911", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011911", "type": "external" } ], "gene_names_uniprotkb": "Lyar", "gene_names_refseq": "Lyar", "protein_names_uniprotkb": "Cell growth-regulating nucleolar protein", "protein_names_refseq": "Ly1 antibody reactive clone; Ly1 antibody reactive homolog; cell growth-regulating nucleolar protein isoform 1; cell growth-regulating nucleolar protein", "tax_id": 10116, "disease": "", "pathway": " (rno:289707)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24990247", "class_list": "", "function": "Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs. Also acts at the level of transcription regulation. Along with PRMT5, binds embryonic globin promoter (By similarity). Represses the expression of embryonic globin Hbb-y gene (By similarity). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and that encoding the small nucleolar RNA SNORD41. Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (By similarity). Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (By similarity). In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines (By similarity). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells. Prevents NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0140416 transcription regulator inhibitor activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045087 innate immune response;GO:0050766 positive regulation of phagocytosis;GO:0006364 rRNA processing;GO:0048821 erythrocyte development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYK5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG06-1", "uniprot_id": [ { "id": "GNL1_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG06", "type": "external" } ], "mass": 68707.0, "length": 607, "protein_name": "Guanine nucleotide-binding protein-like 1", "gene_name": "Gnl1", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein-like 1", "refseq_ac": [ { "id": "NP_997665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997665", "type": "external" } ], "gene_names_uniprotkb": "Gnl1", "gene_names_refseq": "Gnl1", "protein_names_uniprotkb": "Guanine nucleotide-binding protein-like 1", "protein_names_refseq": "guanine nucleotide-binding protein-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:309593)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15060004;22673903", "class_list": "", "function": "Possible regulatory or functional link with the histocompatibility cluster., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "", "go_biological_process": "GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6MG06-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXX0-1", "uniprot_id": [ { "id": "IQCF3_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXX0", "type": "external" } ], "mass": 25011.0, "length": 220, "protein_name": "IQ domain-containing protein F3", "gene_name": "Iqcf3", "organism": "Rat", "refseq_name": "IQ domain-containing protein F3", "refseq_ac": [ { "id": "NP_001020324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020324", "type": "external" } ], "gene_names_uniprotkb": "Iqcf3", "gene_names_refseq": "Iqcf3", "protein_names_uniprotkb": "IQ domain-containing protein F3", "protein_names_refseq": "IQ domain-containing protein F3", "tax_id": 10116, "disease": "", "pathway": " (rno:501050)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXX0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3P7-1", "uniprot_id": [ { "id": "HINT3_RAT", "url": "https://www.uniprot.org/uniprot/Q8K3P7", "type": "external" } ], "mass": 19694.0, "length": 175, "protein_name": "Adenosine 5'-monophosphoramidase HINT3", "gene_name": "Hint3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hint3; Hint4", "gene_names_refseq": "", "protein_names_uniprotkb": "Adenosine 5'-monophosphoramidase HINT3; 3.9.1.-; HINT-3; HINT-4; Histidine triad nucleotide-binding protein 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:246769)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15277470", "class_list": "", "function": "Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.9.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.-", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "2.7.7.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.51", "type": "external" }, { "id": "3.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0043530 adenosine 5'-monophosphoramidase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K3P7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TST9-1", "uniprot_id": [ { "id": "TBX3_RAT", "url": "https://www.uniprot.org/uniprot/Q7TST9", "type": "external" } ], "mass": 79335.0, "length": 743, "protein_name": "T-box transcription factor TBX3", "gene_name": "Tbx3", "organism": "Rat", "refseq_name": "T-box transcription factor TBX3", "refseq_ac": [ { "id": "NP_853669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_853669", "type": "external" } ], "gene_names_uniprotkb": "Tbx3", "gene_names_refseq": "Tbx3", "protein_names_uniprotkb": "T-box transcription factor TBX3; T-box protein 3", "protein_names_refseq": "T-box 3 (ulnar mammary syndrome); T-box protein 3; T-box transcription factor TBX3", "tax_id": 10116, "disease": "ulnar-mammary syndrome (Disease Ontology:DOID:0060614); stomach cancer (Disease Ontology:DOID:10534); depressive disorder (Disease Ontology:DOID:1596); cancer (Disease Ontology:DOID:162); ovarian cancer (Disease Ontology:DOID:2394); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:353305); (R-RNO-9856649)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Transcriptional repressor involved in developmental processes (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (By similarity). Probably plays a role in limb pattern formation (By similarity). Required for mammary placode induction, involved in maintenance of the mammary buds during development and branching morphogenesis in embryonic and adult glands; partially redundant with TBX2 (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005929 cilium;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0032275 luteinizing hormone secretion;GO:0046884 follicle-stimulating hormone secretion;GO:0030540 female genitalia development;GO:0036302 atrioventricular canal development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TST9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTQ1-1", "uniprot_id": [ { "id": "KPCD1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTQ1", "type": "external" } ], "mass": 102043.0, "length": 918, "protein_name": "Serine/threonine-protein kinase D1", "gene_name": "Prkd1", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase D1 isoform 1", "refseq_ac": [ { "id": "NP_001263644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263644", "type": "external" } ], "gene_names_uniprotkb": "Prkd1; Pkcm; Pkd; Prkcm", "gene_names_refseq": "Pkcm; Prkcm; Prkd1; nPKC-D1; nPKC-mu", "protein_names_uniprotkb": "Serine/threonine-protein kinase D1; 2.7.11.13; Protein kinase C mu type; Protein kinase D; nPKC-D1; nPKC-mu", "protein_names_refseq": "protein kinase C mu type; serine/threonine-protein kinase D1 isoform 1; serine/threonine-protein kinase D1", "tax_id": 10116, "disease": "candidiasis (Disease Ontology:DOID:1508); congenital heart disease (Disease Ontology:DOID:1682); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:85421)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10412981;12057008;15145937;15367659;15514163;17306383;18784310;18845574;21041300;22595992;22673903;24039875;31759056;36525926;37963515", "class_list": "", "function": "P2X7 receptor activation of PKCM in rat parotid acinar cells, [RefSeq, PubMed]; Protein kinase D1 promotes the survival of random-pattern skin flaps in rats., [RefSeq, PubMed]; Role of protein kinase D1 in vasoconstriction and haemodynamics in rats., [RefSeq, PubMed]; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10412981, PubMed:15367659, PubMed:15514163). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-469 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1. Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2. In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells (PubMed:18784310). May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:15367659). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation. In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents. In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor. Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (By similarity). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). Acts as a regulator of social behavior by mediating phosphorylation of OXTR, enhancing G(q)-dependent G protein-coupled receptor signaling (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; The results suggest that PKD participates in the development of cardiac hypertrophy by regulating autophagy via AKT/mTOR/S6K pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:1904385 cellular response to angiotensin;GO:1990859 cellular response to endothelin;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9WTQ1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHV8-1", "uniprot_id": [ { "id": "SELS_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHV8", "type": "external" } ], "mass": 21385.0, "length": 190, "protein_name": "Selenoprotein S", "gene_name": "Selenos", "organism": "Rat", "refseq_name": "selenoprotein S", "refseq_ac": [ { "id": "NP_775143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775143", "type": "external" } ], "gene_names_uniprotkb": "Selenos; Vimp", "gene_names_refseq": "Selenos; Sels; Vimp; sg2", "protein_names_uniprotkb": "Selenoprotein S; SelS; Sg2", "protein_names_refseq": "Tanis; VCP-interacting membrane protein; VCP-interacting membrane selenoprotein; selenoprotein S", "tax_id": 10116, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal carcinoma (Disease Ontology:DOID:0080199)", "pathway": " (rno:286900)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26058460", "class_list": "", "function": "Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination., [UniProtKB, UniProtKB, UniProtKB]; Selenoprotein S Is Highly Expressed in the Blood Vessels and Prevents Vascular Smooth Muscle Cells From Apoptosis, [RefSeq, PubMed]; This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion (PMID:23614019). [provided by RefSeq, Jul 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PCV8", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0051117 ATPase binding;GO:0016209 antioxidant activity;GO:1990381 ubiquitin-specific protease binding", "go_cellular_component": "GO:0036502 Derlin-1-VIMP complex;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0034361 very-low-density lipoprotein particle;GO:0034362 low-density lipoprotein particle", "go_biological_process": "GO:0051775 response to redox state;GO:0032715 negative regulation of interleukin-6 production;GO:0032720 negative regulation of tumor necrosis factor production;GO:0071222 cellular response to lipopolysaccharide;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VHV8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PW6-1", "uniprot_id": [ { "id": "MMP24_RAT", "url": "https://www.uniprot.org/uniprot/Q99PW6", "type": "external" } ], "mass": 70465.0, "length": 618, "protein_name": "Matrix metalloproteinase-24", "gene_name": "Mmp24", "organism": "Rat", "refseq_name": "matrix metalloproteinase-24 precursor", "refseq_ac": [ { "id": "NP_113945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113945", "type": "external" } ], "gene_names_uniprotkb": "Mmp24; Mt5mmp", "gene_names_refseq": "MT5MMP; MTMMP5; Mmp24; Mt5-mmp", "protein_names_uniprotkb": "Matrix metalloproteinase-24; 3.4.24.-; MMP-24; MT-MMP 5; MT5-MMP; MT5MMP; MTMMP5; Membrane-type matrix metalloproteinase 5; Membrane-type-5 matrix metalloproteinase", "protein_names_refseq": "MMP-24; MT-MMP 5; matrix metalloproteinase 24 (membrane-inserted); matrix metalloproteinase-24 precursor; matrix metalloproteinase-24; membrane-type matrix metalloproteinase 5; membrane-type-5 matrix metalloproteinase", "tax_id": 10116, "disease": "", "pathway": " (rno:83513); (R-RNO-1592389)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10727639;16495457;22489706", "class_list": "", "function": "Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin., [UniProtKB, PubMed]; These results suggest that ABP directs MT5-MMP proteolytic activity to growth cones and synaptic sites in neurons, where it may regulate axon pathfinding or synapse remodeling through proteolysis of cadherins or other ECM or cell adhesion molecules., [RefSeq, PubMed]; Time- and injury-dependent expression of MT5-MMP, ADAM-10, and N-cadherin are confirmed during reactive synaptogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.24.80", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.80", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0045296 cadherin binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0050965 detection of temperature stimulus involved in sensory perception of pain;GO:0098609 cell-cell adhesion;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99PW6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923V8-1", "uniprot_id": [ { "id": "SEP15_RAT", "url": "https://www.uniprot.org/uniprot/Q923V8", "type": "external" } ], "mass": 17822.0, "length": 162, "protein_name": "Selenoprotein F", "gene_name": "Selenof", "organism": "Rat", "refseq_name": "selenoprotein F precursor", "refseq_ac": [ { "id": "NP_579831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579831", "type": "external" } ], "gene_names_uniprotkb": "Selenof; Sep15", "gene_names_refseq": "Selenof; Sep15", "protein_names_uniprotkb": "Selenoprotein F; 15 kDa selenoprotein", "protein_names_refseq": "15 kDa selenoprotein-like; selenoprotein 15; selenoprotein F precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:113922)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11278576;11898406;15659830;27752786", "class_list": "", "function": "Data show that 15kD selenoprotein (SEP15) protein and selenoprotein R (SELR) protein expression was decreased in the lenses of galactose induced cataract., [RefSeq, PubMed]; Genetic and functional analysis of mammalian Sep15 selenoprotein., [RefSeq, PubMed]; May be involved in redox reactions associated with the formation of disulfide bonds (PubMed:15659830). May contribute to the quality control of protein folding in the endoplasmic reticulum (PubMed:11278576). May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum. May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2., [UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. Knockout studies in mice also suggest a role for this gene in cataract formation and colon carcinogenesis. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Nov 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0008379 thioredoxin peroxidase activity;GO:0008430 selenium binding", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0051084 'de novo' post-translational protein folding;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q923V8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6V7V2-1", "uniprot_id": [ { "id": "RTKN_RAT", "url": "https://www.uniprot.org/uniprot/Q6V7V2", "type": "external" } ], "mass": 61154.0, "length": 548, "protein_name": "Rhotekin", "gene_name": "Rtkn", "organism": "Rat", "refseq_name": "rhotekin isoform 1", "refseq_ac": [ { "id": "NP_908935", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_908935", "type": "external" } ], "gene_names_uniprotkb": "Rtkn", "gene_names_refseq": "Rtkn", "protein_names_uniprotkb": "Rhotekin", "protein_names_refseq": "rhotekin isoform 1", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:297383); (R-RNO-5666185); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "17546647;22411704;22673903", "class_list": "", "function": "Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures (By similarity)., [UniProtKB]; Rhotekin is required for maintenance and survival of neurons and positively regulates differentiation and neurite outgrowth., [RefSeq, PubMed]; SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6V7V1", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0005095 GTPase inhibitor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005826 actomyosin contractile ring", "go_biological_process": "GO:0007165 signal transduction;GO:0006915 apoptotic process;GO:0007266 Rho protein signal transduction;GO:0042981 regulation of apoptotic process;GO:0000281 mitotic cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6V7V2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TXG9-1", "uniprot_id": [ { "id": "SFR1_RAT", "url": "https://www.uniprot.org/uniprot/Q6TXG9", "type": "external" } ], "mass": 28729.0, "length": 251, "protein_name": "Swi5-dependent recombination DNA repair protein 1 homolog", "gene_name": "Sfr1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sfr1; Mei5; Meir5", "gene_names_refseq": "", "protein_names_uniprotkb": "Swi5-dependent recombination DNA repair protein 1 homolog; Liver regeneration-related protein LRRGT00030; Meiosis protein 5 homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:294030)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. Acts as a transcriptional modulator for ESR1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0032798 Swi5-Sfr1 complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0000724 double-strand break repair via homologous recombination;GO:0071391 cellular response to estrogen stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6TXG9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG62-1", "uniprot_id": [ { "id": "MSH5_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG62", "type": "external" } ], "mass": 92452.0, "length": 831, "protein_name": "MutS protein homolog 5", "gene_name": "Msh5", "organism": "Rat", "refseq_name": "mutS protein homolog 5", "refseq_ac": [ { "id": "NP_997701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997701", "type": "external" } ], "gene_names_uniprotkb": "Msh5", "gene_names_refseq": "Msh5", "protein_names_uniprotkb": "MutS protein homolog 5", "protein_names_refseq": "mutS protein homolog 5", "tax_id": 10116, "disease": "spermatogenic failure 74 (Disease Ontology:DOID:0070573); primary ovarian insufficiency 13 (Disease Ontology:DOID:0080870); lung non-small cell carcinoma (Disease Ontology:DOID:3908); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (rno:294252)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15060004", "class_list": "", "function": "Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5XHZ5", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003690 double-stranded DNA binding;GO:0030983 mismatched DNA binding;GO:0140664 ATP-dependent DNA damage sensor activity", "go_cellular_component": "GO:0005634 nucleus;GO:1990391 DNA repair complex;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0006298 mismatch repair;GO:0007129 homologous chromosome pairing at meiosis;GO:0007292 female gamete generation;GO:0051026 chiasma assembly;GO:0007127 meiosis I", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6MG62-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVR3-1", "uniprot_id": [ { "id": "SHIP2_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVR3", "type": "external" } ], "mass": 139143.0, "length": 1257, "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2", "gene_name": "Inppl1", "organism": "Rat", "refseq_name": "phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform 2", "refseq_ac": [ { "id": "NP_001257772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257772", "type": "external" } ], "gene_names_uniprotkb": "Inppl1; Ship2", "gene_names_refseq": "Inppl1; Ship2", "protein_names_uniprotkb": "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; 3.1.3.86; INPPL-1; Inositol polyphosphate phosphatase-like protein 1; Protein 51C; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SHIP-2", "protein_names_refseq": "INPPL-1; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SH2-containing inositol phosphatase 2; SHIP-2; inositol polyphosphate phosphatase-like protein 1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform 2; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; protein 51C", "tax_id": 10116, "disease": "scoliosis (Disease Ontology:DOID:0060249); hypertension (Disease Ontology:DOID:10763); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:65038); (R-RNO-1660499); (R-RNO-1855204); (R-RNO-912526)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10381377;10648902;11238900;12086927;12351701;17535963;17893321;22247557;22673903", "class_list": "", "function": "Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:11238900, PubMed:17535963). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:11238900). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (PubMed:10381377, PubMed:12351701). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (By similarity). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (By similarity). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (By similarity). Regulates cell adhesion and cell spreading (By similarity). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (By similarity). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (By similarity). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (PubMed:17535963). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (By similarity). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (By similarity). Involved in EGF signaling pathway (By similarity). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (By similarity). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (By similarity). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP)., [RefSeq, PubMed]; SHIP2-mediated negative feedback on PIP(3) coordinately works with the PI3-kinase-mediated positive feedback to maintain proper neurite outgrowth., [RefSeq, PubMed]; These results reveal the existence of two distinct pools of PI3K lipids in myoblasts: a pool dephosphorylated by PTEN, capable of activating Akt and promoting myoblast differentiation and a stable pool dephosphorylated by Ship2 and unable to activate Akt., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1V2", "ec_number_list": [ { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0017124 SH3 domain binding;GO:0042169 SH2 domain binding;GO:0004445 inositol-polyphosphate 5-phosphatase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0006629 lipid metabolic process;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WVR3-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K415-1", "uniprot_id": [ { "id": "S36A2_RAT", "url": "https://www.uniprot.org/uniprot/Q8K415", "type": "external" } ], "mass": 52278.0, "length": 481, "protein_name": "Proton-coupled amino acid transporter 2", "gene_name": "Slc36a2", "organism": "Rat", "refseq_name": "proton-coupled amino acid transporter 2", "refseq_ac": [ { "id": "NP_647555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647555", "type": "external" } ], "gene_names_uniprotkb": "Slc36a2; Pat2; Tramd1", "gene_names_refseq": "Pat2; Slc36a2; Tramd1", "protein_names_uniprotkb": "Proton-coupled amino acid transporter 2; Proton/amino acid transporter 2; Solute carrier family 36 member 2; Tramdorin-1; Transmembrane domain rich protein 1; rPAT2", "protein_names_refseq": "proton-coupled amino acid transporter 2; proton/amino acid transporter 2; rPAT2; solute carrier family 36 (proton/amino acid symporter), member 2; tramdorin-1; transmembrane domain rich protein 1", "tax_id": 10116, "disease": "iminoglycinuria (Disease Ontology:DOID:0112265)", "pathway": " (rno:246235); (R-RNO-352230); (R-RNO-428559)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12451123;12727219;15644866;20691150", "class_list": "", "function": "Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2), [RefSeq, PubMed]; Electrogenic proton/amino acid symporter with a high selectivity for the small side chains amino acids glycine, alanine and proline, where both L- and D-enantiomers are transported. Extension of the backbone length, as in beta-alanine and 4-aminobutanoate or methylation of the amino group, as in sarcosine and N,N-dimethylglycine, are also tolerated but decrease transport efficiency. A free carboxyl group is preferred., [UniProtKB, PubMed, PubMed]; Isolation of PAT2 from a rat lung cDNA library; PAT2 has a limited tissue distribution, higher affinity, and distinct substrate specificity compared to PAT1, [RefSeq, PubMed]; Subtrate specificity and functional characterization of Pat2 were studied., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015180 L-alanine transmembrane transporter activity;GO:0015187 glycine transmembrane transporter activity;GO:0015193 L-proline transmembrane transporter activity;GO:0005280 amino acid:proton symporter activity;GO:0005297 proline:proton symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0055038 recycling endosome membrane;GO:0005774 vacuolar membrane;GO:0016020 membrane", "go_biological_process": "GO:0015816 glycine transport;GO:0010155 regulation of proton transport;GO:0015824 proline transport;GO:0035524 proline transmembrane transport;GO:0015808 L-alanine transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K415-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJM9-1", "uniprot_id": [ { "id": "SEPT5_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJM9", "type": "external" } ], "mass": 42852.0, "length": 369, "protein_name": "Septin-5", "gene_name": "Septin5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Septin5; Pnutl1; Sept5", "gene_names_refseq": "", "protein_names_uniprotkb": "Septin-5; CDCrel-1; Cell division control-related protein 1; Peanut-like protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:116728)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10873671;18683930;18938227;22673903", "class_list": "", "function": "Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity)., [UniProtKB]; Filament-forming cytoskeletal GTPase., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R2F7;Q9JJM8", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005940 septin ring;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0043195 terminal bouton", "go_biological_process": "GO:0030534 adult behavior;GO:0035176 social behavior;GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis;GO:0017157 regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JJM9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Y306-1", "uniprot_id": [ { "id": "MRP9_RAT", "url": "https://www.uniprot.org/uniprot/Q6Y306", "type": "external" } ], "mass": 152965.0, "length": 1366, "protein_name": "ATP-binding cassette sub-family C member 12", "gene_name": "Abcc12", "organism": "Rat", "refseq_name": "ATP-binding cassette sub-family C member 12", "refseq_ac": [ { "id": "NP_955409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955409", "type": "external" } ], "gene_names_uniprotkb": "Abcc12; Mrp9", "gene_names_refseq": "Abcc12", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 12; Multidrug resistance-associated protein 9", "protein_names_refseq": "ATP-binding cassette sub-family C member 12; ATP-binding cassette transporter sub-family C member 12; ATP-binding cassette, sub-family C (CFTR/MRP), member 12; ATP-binding cassette, subfamily C (CFTR/MRP), member 12; multidrug resistance-associated protein 9", "tax_id": 10116, "disease": "cystic fibrosis (Disease Ontology:DOID:1485)", "pathway": " (rno:291923)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17472575", "class_list": "", "function": "Probable transporter, its substrate specificity is unknown., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6Y305", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system;GO:0005886 plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6Y306-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6V7-1", "uniprot_id": [ { "id": "TCAF3_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6V7", "type": "external" } ], "mass": 102094.0, "length": 914, "protein_name": "TRPM8 channel-associated factor 3", "gene_name": "Fam115e; Tcaf3", "organism": "Rat", "refseq_name": "TRPM8 channel-associated factor 3", "refseq_ac": [ { "id": "NP_001009534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009534", "type": "external" } ], "gene_names_uniprotkb": "Fam115e; Tcaf3; Eapa2; Fam115e", "gene_names_refseq": "Eapa2; Fam115e; Tcaf3", "protein_names_uniprotkb": "TRPM8 channel-associated factor 3; Experimental autoimmune prostatitis antigen 2 homolog", "protein_names_refseq": "TRPM8 channel-associated factor 3; experimental autoimmune prostatitis antigen 2 homolog; protein FAM115E", "tax_id": 10116, "disease": "", "pathway": " (rno:494321)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in the regulation of the cation channel TRPM8 activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0090314 positive regulation of protein targeting to membrane;GO:0010360 negative regulation of anion channel activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P6V7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Q3F5-1", "uniprot_id": [ { "id": "SIDT1_RAT", "url": "https://www.uniprot.org/uniprot/Q6Q3F5", "type": "external" } ], "mass": 94145.0, "length": 831, "protein_name": "SID1 transmembrane family member 1", "gene_name": "Sidt1", "organism": "Rat", "refseq_name": "SID1 transmembrane family member 1 precursor", "refseq_ac": [ { "id": "NP_001094123", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094123", "type": "external" } ], "gene_names_uniprotkb": "Sidt1", "gene_names_refseq": "Sidt1", "protein_names_uniprotkb": "SID1 transmembrane family member 1", "protein_names_refseq": "Msid2; SID1 transmembrane family member 1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:288109)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24090084", "class_list": "", "function": "In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015485 cholesterol binding;GO:0003725 double-stranded RNA binding;GO:0051033 RNA transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0016020 membrane", "go_biological_process": "GO:0050658 RNA transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6Q3F5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTQ0-1", "uniprot_id": [ { "id": "KPCT_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTQ0", "type": "external" } ], "mass": 81750.0, "length": 707, "protein_name": "Protein kinase C theta type", "gene_name": "Prkcq", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prkcq; Pkcq", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein kinase C theta type; 2.7.11.13; nPKC-theta", "protein_names_refseq": "", "tax_id": 10116, "disease": "hyperinsulinism (Disease Ontology:DOID:2018); prostate adenocarcinoma (Disease Ontology:DOID:2526); retinal detachment (Disease Ontology:DOID:5327)", "pathway": " (rno:85420); (R-RNO-111465); (R-RNO-114508); (R-RNO-202424); (R-RNO-2871837); (R-RNO-373752); (R-RNO-9648002)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "11220785;18295358;18479680;22673903;9516463", "class_list": "", "function": "Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" } ], "go_molecular_function": "GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031594 neuromuscular junction;GO:0042383 sarcolemma;GO:0034451 centriolar satellite", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0032740 positive regulation of interleukin-17 production;GO:2000570 positive regulation of T-helper 2 cell activation;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WTQ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CH34-1", "uniprot_id": [ { "id": "ZP4_RAT", "url": "https://www.uniprot.org/uniprot/Q8CH34", "type": "external" } ], "mass": 59874.0, "length": 545, "protein_name": "Zona pellucida sperm-binding protein 4", "gene_name": "Zp4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zp4; Zpb", "gene_names_refseq": "", "protein_names_uniprotkb": "Zona pellucida sperm-binding protein 4; Zona pellucida glycoprotein 4; Zona pellucida protein B; Zp-4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:282833)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 5, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035804 structural constituent of egg coat;GO:0032190 acrosin binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0035805 egg coat", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0007339 binding of sperm to zona pellucida;GO:0042102 positive regulation of T cell proliferation;GO:0060468 prevention of polyspermy;GO:2000360 negative regulation of binding of sperm to zona pellucida", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CH34-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0A3-1", "uniprot_id": [ { "id": "SPAT7_RAT", "url": "https://www.uniprot.org/uniprot/Q9R0A3", "type": "external" } ], "mass": 59983.0, "length": 526, "protein_name": "Spermatogenesis-associated protein 7 homolog", "gene_name": "Spata7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Spata7; Rsd3", "gene_names_refseq": "", "protein_names_uniprotkb": "Spermatogenesis-associated protein 7 homolog; Fertility-related protein WMP1; RSD-3; Rat sperm DNA no.3", "protein_names_refseq": "", "tax_id": 10116, "disease": "Leber congenital amaurosis 3 (Disease Ontology:DOID:0110331)", "pathway": " (rno:192225)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12736779", "class_list": "", "function": "Involved in the maintenance of both rod and cone photoreceptor cells (By similarity). Required for photoreceptor-specific localization of proximal connecting cilium (CC) proteins RPGR, AHI1, NPHP1, NPHP4, and RPGRIP1 at the distal CC, a photoreceptor-specific extension of the primary cilium transition zone (By similarity). Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0015630 microtubule cytoskeleton;GO:0005930 axoneme;GO:0036064 ciliary basal body;GO:0032391 photoreceptor connecting cilium;GO:0097225 sperm midpiece", "go_biological_process": "GO:1903621 protein localization to photoreceptor connecting cilium;GO:0007283 spermatogenesis;GO:0045494 photoreceptor cell maintenance;GO:0000226 microtubule cytoskeleton organization;GO:1903546 protein localization to photoreceptor outer segment", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9R0A3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76M68-1", "uniprot_id": [ { "id": "IQEC3_RAT", "url": "https://www.uniprot.org/uniprot/Q76M68", "type": "external" } ], "mass": 129018.0, "length": 1194, "protein_name": "IQ motif and SEC7 domain-containing protein 3", "gene_name": "Iqsec3", "organism": "Rat", "refseq_name": "IQ motif and SEC7 domain-containing protein 3", "refseq_ac": [ { "id": "NP_997500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997500", "type": "external" } ], "gene_names_uniprotkb": "Iqsec3; Sag", "gene_names_refseq": "Iqsec3; sag", "protein_names_uniprotkb": "IQ motif and SEC7 domain-containing protein 3; Potential synaptic guanine nucleotide exchange factor for Arf; SynArfGEF-Po", "protein_names_refseq": "IQ motif and SEC7 domain-containing protein 3; IQ motif and Sec7 domain 3; potential synaptic guanine nucleotide exchange factor for Arf; synArfGEF-Po; synArfGEF", "tax_id": 10116, "disease": "", "pathway": " (rno:404781)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15189337;22673903;27002143;30142695", "class_list": "", "function": "Acts as a guanine nucleotide exchange factor (GEF) for ARF1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Cloned from a rat brain cDNA library; both the mRNA and the protein were localized in the postsynaptic compartments; results suggest a postsynaptic role of synArfGEF in the brain, [RefSeq, PubMed]; These data reveal that IQSEC3 acts together with gephyrin to regulate inhibitory synapse development., [RefSeq, PubMed]; We provide biochemical evidence to confirm gephyrin/IQSEC3 interaction near the IQSEC3 IQ motif, which in turn binds calmodulin at low Ca(2+) concentrations, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0045211 postsynaptic membrane;GO:0060077 inhibitory synapse", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0016192 vesicle-mediated transport;GO:0090630 activation of GTPase activity;GO:0032012 regulation of ARF protein signal transduction;GO:0099173 postsynapse organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q76M68-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99P55-1", "uniprot_id": [ { "id": "SGPP1_RAT", "url": "https://www.uniprot.org/uniprot/Q99P55", "type": "external" } ], "mass": 47649.0, "length": 430, "protein_name": "Sphingosine-1-phosphate phosphatase 1", "gene_name": "Sgpp1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sgpp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sphingosine-1-phosphate phosphatase 1; 3.1.3.-; SPPase1; Sphingosine-1-phosphatase 1; Spp1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:81536); (R-RNO-9845614)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid. Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway. Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (By similarity). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity). Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic reticulum to the Golgi apparatus (By similarity). The modulation of intracellular ceramide levels in turn regulates apoptosis (By similarity). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries. Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (By similarity). Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "3.6.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75", "type": "external" } ], "go_molecular_function": "GO:0070780 dihydrosphingosine-1-phosphate phosphatase activity;GO:0042392 sphingosine-1-phosphate phosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006670 sphingosine metabolic process;GO:0006665 sphingolipid metabolic process;GO:0097191 extrinsic apoptotic signaling pathway;GO:0097193 intrinsic apoptotic signaling pathway;GO:0045616 regulation of keratinocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99P55-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QX72-1", "uniprot_id": [ { "id": "SEBP2_RAT", "url": "https://www.uniprot.org/uniprot/Q9QX72", "type": "external" } ], "mass": 93300.0, "length": 846, "protein_name": "Selenocysteine insertion sequence-binding protein 2", "gene_name": "Secisbp2", "organism": "Rat", "refseq_name": "selenocysteine insertion sequence-binding protein 2", "refseq_ac": [ { "id": "NP_076492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076492", "type": "external" } ], "gene_names_uniprotkb": "Secisbp2; Sbp2", "gene_names_refseq": "Sbp2; Secisbp2", "protein_names_uniprotkb": "Selenocysteine insertion sequence-binding protein 2; SECIS-binding protein 2", "protein_names_refseq": "selenocysteine insertion sequence-binding protein 2", "tax_id": 10116, "disease": "thyroid gland disease (Disease Ontology:DOID:50)", "pathway": " (rno:79049)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10464275;10637234;22673903;22992746;23777426;25692238", "class_list": "", "function": "Data show that a purified recombinant protein encompassing amino acids 517-777 of SECIS-binding protein 2 (SBP2) binds to SECIS elements with high affinity and selectivity., [RefSeq, PubMed]; L30 and SBP2 bind to overlapping but non-identical sites on the SECIS. Publication Status: Online-Only, [RefSeq, PubMed]; SBP2/SECIS complex activates eEFSec by directing functional interactions between Domain IV and the ribosome to promote Sec-tRNA(Sec) binding and accommodation into the ribosomal A-site, [RefSeq, PubMed]; mRNA-binding protein that binds to the SECIS (selenocysteine insertion sequence) element present in the 3'-UTR of mRNAs encoding selenoproteins and facilitates the incorporation of the rare amino acid selenocysteine (PubMed:10464275, PubMed:10637234). Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling (By similarity). (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation (By similarity). (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035368 selenocysteine insertion sequence binding;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0043021 ribonucleoprotein complex binding;GO:0008135 translation factor activity, RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0001514 selenocysteine incorporation;GO:0048255 mRNA stabilization;GO:0006412 translation;GO:0048666 neuron development;GO:0021756 striatum development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QX72-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ET62-1", "uniprot_id": [ { "id": "IMPG1_RAT", "url": "https://www.uniprot.org/uniprot/Q9ET62", "type": "external" } ], "mass": 89950.0, "length": 798, "protein_name": "Interphotoreceptor matrix proteoglycan 1", "gene_name": "Impg1", "organism": "Rat", "refseq_name": "interphotoreceptor matrix proteoglycan 1 precursor", "refseq_ac": [ { "id": "NP_076448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076448", "type": "external" } ], "gene_names_uniprotkb": "Impg1; Mlgapc", "gene_names_refseq": "Impg1; Mlgapc", "protein_names_uniprotkb": "Interphotoreceptor matrix proteoglycan 1; Mucin-like glycoprotein associated with photoreceptor cells; Sialoprotein associated with cones and rods", "protein_names_refseq": "interphotoreceptor matrix proteoglycan 1 precursor; mucin-like glycoprotein associated with photoreceptor cells; sialoprotein associated with cones and rods", "tax_id": 10116, "disease": "vitelliform macular dystrophy (Disease Ontology:DOID:0050661); retinitis pigmentosa 91 (Disease Ontology:DOID:0061106)", "pathway": " (rno:66014)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11914607", "class_list": "", "function": "Chondroitin sulfate-, heparin- and hyaluronan-binding protein (By similarity). May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Chondroitin sulfate-, heparin- and hyaluronan-binding protein. May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 5, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0035374 chondroitin sulfate binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0033165 interphotoreceptor matrix;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9ET62-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Z70-1", "uniprot_id": [ { "id": "SE1L1_RAT", "url": "https://www.uniprot.org/uniprot/Q80Z70", "type": "external" } ], "mass": 88683.0, "length": 794, "protein_name": "Protein sel-1 homolog 1", "gene_name": "Sel1l", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sel1l; Sel1h", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein sel-1 homolog 1; Sel-1L; Suppressor of lin-12-like protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (rno:314352); (R-RNO-382556); (R-RNO-5358346); (R-RNO-9931269)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "11401526;24090084;38843836", "class_list": "", "function": "Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells (By similarity). May play a role in Notch signaling (PubMed:11401526)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0036513 Derlin-1 retrotranslocation complex;GO:0000836 Hrd1p ubiquitin ligase complex;GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0007219 Notch signaling pathway;GO:0009306 protein secretion;GO:0036503 ERAD pathway;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q80Z70-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6R7-1", "uniprot_id": [ { "id": "SGSM3_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6R7", "type": "external" } ], "mass": 85188.0, "length": 749, "protein_name": "Small G protein signaling modulator 3", "gene_name": "Sgsm3", "organism": "Rat", "refseq_name": "small G protein signaling modulator 3", "refseq_ac": [ { "id": "NP_942082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942082", "type": "external" } ], "gene_names_uniprotkb": "Sgsm3; Bdif1; Rutbc3", "gene_names_refseq": "Rutbc3; Sgsm3; bdif-1", "protein_names_uniprotkb": "Small G protein signaling modulator 3; BDIF-1; RUN and TBC1 domain-containing protein 3", "protein_names_refseq": "RUN and TBC1 domain containing 3; RUN and TBC1 domain-containing protein 3; small G protein signaling modulator 3", "tax_id": 10116, "disease": "", "pathway": " (rno:362963)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21453730;22673903;28716730", "class_list": "", "function": "BDIF1 potentially functions in molecular trafficking of astrocytes., [RefSeq, PubMed]; GTPase-activating protein (GAP) specific for Rab5 small GTPase for which it accelerates the intrinsic GTP hydrolysis rate, thereby controlling trafficking through the early endocytic pathway. May play a cooperative role in NF2-mediated growth suppression of cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; High levels of SGSM3 appeared to induce the turnover of Cx43 through lysosomal degradation in myocardial infarcted rat hearts., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q76KK4", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005921 gap junction", "go_biological_process": "GO:0032483 regulation of Rab protein signal transduction;GO:0032486 Rap protein signal transduction;GO:0030100 regulation of endocytosis;GO:0043547 positive regulation of GTPase activity;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6P6R7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P3V7-1", "uniprot_id": [ { "id": "TTC41_RAT", "url": "https://www.uniprot.org/uniprot/Q6P3V7", "type": "external" } ], "mass": 150287.0, "length": 1309, "protein_name": "Tetratricopeptide repeat protein 41", "gene_name": "Ttc41", "organism": "Rat", "refseq_name": "tetratricopeptide repeat protein 41 isoform X3", "refseq_ac": [ { "id": "XP_063119832", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063119832", "type": "external" } ], "gene_names_uniprotkb": "Ttc41; Gnn", "gene_names_refseq": "Gnn; Ttc41", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 41; Grp94-neighboring nucleotidase; TPR repeat protein 41", "protein_names_refseq": "tetratricopeptide repeat protein 41 isoform X3", "tax_id": 10116, "disease": "", "pathway": " (rno:362863)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P3V7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923M1-1", "uniprot_id": [ { "id": "MSRA_RAT", "url": "https://www.uniprot.org/uniprot/Q923M1", "type": "external" } ], "mass": 25851.0, "length": 233, "protein_name": "Mitochondrial peptide methionine sulfoxide reductase", "gene_name": "Msra", "organism": "Rat", "refseq_name": "mitochondrial peptide methionine sulfoxide reductase", "refseq_ac": [ { "id": "NP_445759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445759", "type": "external" } ], "gene_names_uniprotkb": "Msra", "gene_names_refseq": "Msra", "protein_names_uniprotkb": "Mitochondrial peptide methionine sulfoxide reductase; 1.8.4.11; PMSR; Peptide Met(O) reductase; Peptide-methionine (S)-S-oxide reductase; Protein-methionine-S-oxide reductase", "protein_names_refseq": "PMSR; mitochondrial peptide methionine sulfoxide reductase; peptide Met(O) reductase; peptide methionine sulfoxide reductase; peptide-methionine (S)-S-oxide reductase; protein-methionine-S-oxide reductase", "tax_id": 10116, "disease": "", "pathway": " (rno:29447); (R-RNO-5676934)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11311146;12693988;14745014;17907003;23036869;24120970;24315642;25602783;30717164", "class_list": "", "function": "Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Has an important function as a repair enzyme for proteins that have been inactivated by oxidation (PubMed:12693988). Plays a crucial role in repairing oxidized methionine residues in key lens proteins, such as alpha-crystallin (CRYAA/CRYAB) and cytochrome c (CYCS), thereby restoring their function and maintaining lens transparency., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Methionine sulfoxide reductase A plays a protective role against hypoxia/reoxygenation-induced cell injury., [RefSeq, PubMed]; Msr play important roles in pancreatic stellate cell function. Publication Status: Online-Only, [RefSeq, PubMed]; MsrA overexpression in MsrA-depleted cells led to the reduction of increased HO-1 expression, and suppressed nuclear accumulation of Nrf2., [RefSeq, PubMed]; MsrA probably enhances ATP synthesis by increasing complex IV activity., [RefSeq, PubMed]; Multiple MSRA variants participate in the repair of oxidized proteins in vascular smooth muscle cells mitochondria., [RefSeq, PubMed]; Specific colorimetric microplate assay for testing MsrA activity quickly, based on the fact that MsrA can catalyze the reduction of methyl sulfoxides and simultaneously oxidize dithiothreitol, whose color can be produced by reacting with Ellman's reagent., [RefSeq, PubMed]; The study provides the first direct evidence for the biological significance of MsrA in microglia-mediated neuroinflammation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A9LAT3;A9LAT4", "ec_number_list": [ { "id": "1.8.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.11", "type": "external" } ], "go_molecular_function": "GO:0008113 peptide-methionine (S)-S-oxide reductase activity;GO:0033744 L-methionine:thioredoxin-disulfide S-oxidoreductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q923M1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1M9-1", "uniprot_id": [ { "id": "SMC1A_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1M9", "type": "external" } ], "mass": 143205.0, "length": 1233, "protein_name": "Structural maintenance of chromosomes protein 1A", "gene_name": "Smc1a", "organism": "Rat", "refseq_name": "structural maintenance of chromosomes protein 1A", "refseq_ac": [ { "id": "NP_113871", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113871", "type": "external" } ], "gene_names_uniprotkb": "Smc1a; Smc1l1; Smc1", "gene_names_refseq": "SB1.8; SMC-1A; Smc1a; Smc1l1", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 1A; SMC protein 1A; SMC-1A", "protein_names_refseq": "DXhXs423e; SMC (segregation of mitotic chromosomes 1)-like 1; SMC protein 1A; SMC-like 1; SMC-protein; segregation of mitotic chromosomes-like 1; structural maintenance of chromosomes 1 like 1; structural maintenance of chromosomes protein 1A", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 85 (Disease Ontology:DOID:0070380); Cornelia de Lange syndrome 2 (Disease Ontology:DOID:0080506); Cornelia de Lange syndrome (Disease Ontology:DOID:11725); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:63996); (R-RNO-2467813); (R-RNO-2468052); (R-RNO-2470946); (R-RNO-2500257); (R-RNO-3108214)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "10652260;22673903;23638217", "class_list": "", "function": "Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint., [UniProtKB]; These results suggest that SMC1A upregulation is involved in the pathogenesis of glioma. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0046982 protein heterodimerization activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0030892 mitotic cohesin complex;GO:0030893 meiotic cohesin complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006281 DNA repair;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0019827 stem cell population maintenance;GO:0009314 response to radiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z1M9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV63-1", "uniprot_id": [ { "id": "KIF2A_RAT", "url": "https://www.uniprot.org/uniprot/Q9WV63", "type": "external" } ], "mass": 79792.0, "length": 705, "protein_name": "Kinesin-like protein KIF2A", "gene_name": "Kif2a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kif2a; Kif2", "gene_names_refseq": "", "protein_names_uniprotkb": "Kinesin-like protein KIF2A; Kinesin-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "complex cortical dysplasia with other brain malformations 3 (Disease Ontology:DOID:0090134)", "pathway": " (rno:84391); (R-RNO-141430); (R-RNO-141444); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-6811434); (R-RNO-68877); (R-RNO-9648025); (R-RNO-983189)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "22673903;38843836", "class_list": "", "function": "Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5BJW1", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WV63-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P7A2-1", "uniprot_id": [ { "id": "UBE4A_RAT", "url": "https://www.uniprot.org/uniprot/Q6P7A2", "type": "external" } ], "mass": 122379.0, "length": 1066, "protein_name": "Ubiquitin conjugation factor E4 A", "gene_name": "Ube4a", "organism": "Rat", "refseq_name": "ubiquitin conjugation factor E4 A", "refseq_ac": [ { "id": "NP_997493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997493", "type": "external" } ], "gene_names_uniprotkb": "Ube4a", "gene_names_refseq": "Ab2-232; Ube4a", "protein_names_uniprotkb": "Ubiquitin conjugation factor E4 A; 2.3.2.27; RING-type E3 ubiquitin transferase E4 A", "protein_names_refseq": "RING-type E3 ubiquitin transferase E4 A; ubiquitin conjugation factor E4 A; ubiquitination factor E4A (UFD2 homolog, yeast); ubiquitination factor E4A, UFD2 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:315608); (R-RNO-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0034450 ubiquitin-ubiquitin ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P7A2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSY4-1", "uniprot_id": [ { "id": "ZP3R_RAT", "url": "https://www.uniprot.org/uniprot/Q7TSY4", "type": "external" } ], "mass": 64373.0, "length": 577, "protein_name": "Zona pellucida sperm-binding protein 3 receptor", "gene_name": "Zp3r", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zp3r; Sp56", "gene_names_refseq": "", "protein_names_uniprotkb": "Zona pellucida sperm-binding protein 3 receptor; Sperm fertilization protein 56; sp56", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:289010)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12737520", "class_list": "", "function": "Binds to ZP3 glycoprotein in egg zona pellucida. Probably involved in interactions between sperm acrosome and egg zona pellucida during and immediately following the acrosome reaction (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSY3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0043159 acrosomal matrix;GO:0043160 acrosomal lumen", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0045959 negative regulation of complement activation, classical pathway;GO:0002456 T cell mediated immunity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TSY4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3K4-1", "uniprot_id": [ { "id": "SPB10_RAT", "url": "https://www.uniprot.org/uniprot/Q8K3K4", "type": "external" } ], "mass": 45387.0, "length": 397, "protein_name": "Serpin B10", "gene_name": "Serpinb10", "organism": "Rat", "refseq_name": "serpin B10", "refseq_ac": [ { "id": "NP_714955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_714955", "type": "external" } ], "gene_names_uniprotkb": "Serpinb10", "gene_names_refseq": "Serpinb10; Trespin", "protein_names_uniprotkb": "Serpin B10; TGF-beta-repressible serine proteinase inhibitor; Transforming growth factor beta repressible serpin; Trespin", "protein_names_refseq": "TGF-beta-repressible serine proteinase inhibitor; serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 10; serpin B10; serpin peptidase inhibitor, clade B (ovalbumin), member 10; transforming growth factor beta repressible serpin", "tax_id": 10116, "disease": "", "pathway": " (rno:266775); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11986314;12651162", "class_list": "", "function": "Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus (By similarity). Inhibits plasmin., [UniProtKB, PubMed]; Trespin decreases after differentiation of NRP-152 cells to a luminal variant, suggesting Trespin is specific for basal prostatic epithelial cells. Trespin is up-regulated by dexamethasone and IGF-I., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7C1", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045861 negative regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K3K4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K451-1", "uniprot_id": [ { "id": "GP156_RAT", "url": "https://www.uniprot.org/uniprot/Q8K451", "type": "external" } ], "mass": 86426.0, "length": 792, "protein_name": "Probable G protein-coupled receptor 156", "gene_name": "Gpr156", "organism": "Rat", "refseq_name": "probable G-protein coupled receptor 156", "refseq_ac": [ { "id": "NP_695207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_695207", "type": "external" } ], "gene_names_uniprotkb": "Gpr156; Gababl", "gene_names_refseq": "Gababl; Gpr156", "protein_names_uniprotkb": "Probable G protein-coupled receptor 156; GABAB-related G protein-coupled receptor", "protein_names_refseq": "GABAB-related G-protein coupled receptor; probable G-protein coupled receptor 156", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness (Disease Ontology:DOID:0050565)", "pathway": " (rno:260430)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12591167;14707142", "class_list": "", "function": "GABAB receptor cell surface stability is modulated by phosphorylation and chronic agonist treatment, [RefSeq, PubMed]; Orphan G protein-coupled receptor involved in the regulation of hair cell orientation in mechanosensory organs of the inner ear. It is required to trigger a 180 degree reversal in hair cell orientation, creating a virtual line of polarity reversal (LPR) across which stereociliary bundles are arranged in opposite orientations., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004965 G protein-coupled GABA receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0038039 G protein-coupled receptor heterodimeric complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0160194 stereocilium bundle organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K451-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4K5-1", "uniprot_id": [ { "id": "L2GL1_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4K5", "type": "external" } ], "mass": 112495.0, "length": 1036, "protein_name": "Lethal(2) giant larvae protein homolog 1", "gene_name": "Llgl1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Llgl1; Rgl1", "gene_names_refseq": "", "protein_names_uniprotkb": "Lethal(2) giant larvae protein homolog 1; LLGL; Rgl-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "brain cancer (Disease Ontology:DOID:1319); dihydropyrimidine dehydrogenase deficiency (Disease Ontology:DOID:14218); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); kidney cancer (Disease Ontology:DOID:263); carcinoma (Disease Ontology:DOID:305); gallbladder cancer (Disease Ontology:DOID:3121); liver disease (Disease Ontology:DOID:409); neuroblastoma (Disease Ontology:DOID:769); colorectal cancer (Disease Ontology:DOID:9256); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:54265)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12012002;21856246;22673903;38843836", "class_list": "", "function": "Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045159 myosin II binding;GO:0005096 GTPase activator activity;GO:0019901 protein kinase binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0035748 myelin sheath abaxonal region;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0051294 establishment of spindle orientation;GO:0032878 regulation of establishment or maintenance of cell polarity;GO:0007409 axonogenesis;GO:0030866 cortical actin cytoskeleton organization;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K4K5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0D6-1", "uniprot_id": [ { "id": "TCO2_RAT", "url": "https://www.uniprot.org/uniprot/Q9R0D6", "type": "external" } ], "mass": 47420.0, "length": 427, "protein_name": "Transcobalamin-2", "gene_name": "Tcn2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tcn2", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcobalamin-2; TC II; TC-2; TCII; Transcobalamin II", "protein_names_refseq": "", "tax_id": 10116, "disease": "transcobalamin II deficiency (Disease Ontology:DOID:0050818); megaloblastic anemia (Disease Ontology:DOID:13382); Parkinson's disease (Disease Ontology:DOID:14330); cryoglobulinemia (Disease Ontology:DOID:2917); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:64365); (R-RNO-9758890)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15488467", "class_list": "", "function": "Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0031419 cobalamin binding;GO:0140355 cargo receptor ligand activity;GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0015889 cobalamin transport;GO:0006824 cobalt ion transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9R0D6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R515-1", "uniprot_id": [ { "id": "ZHX1_RAT", "url": "https://www.uniprot.org/uniprot/Q8R515", "type": "external" } ], "mass": 97570.0, "length": 873, "protein_name": "Zinc fingers and homeoboxes protein 1", "gene_name": "Zhx1", "organism": "Rat", "refseq_name": "zinc fingers and homeoboxes protein 1", "refseq_ac": [ { "id": "NP_598304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598304", "type": "external" } ], "gene_names_uniprotkb": "Zhx1", "gene_names_refseq": "Zhx1", "protein_names_uniprotkb": "Zinc fingers and homeoboxes protein 1", "protein_names_refseq": "zinc finger and homeodomain protein 1; zinc fingers and homeoboxes protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:171159)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12062805;17056598;17457373;22673903", "class_list": "", "function": "Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Upregulation of B7.1 with the downregulation of GLEPP1, Wilms' tumor gene (WT1), megalin, and vascular endothelial growth factor started early and persisted through the course of primary glomerular disease., [RefSeq, PubMed]; ZHX proteins 1, 2 and 3 are major transcriptional mediators of podocyte disease Erratum:[J Biol Chem. 2007 Apr 27;282(17):13140], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0046982 protein heterodimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R515-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPI8-1", "uniprot_id": [ { "id": "MTEF1_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPI8", "type": "external" } ], "mass": 42937.0, "length": 374, "protein_name": "Transcription termination factor 1, mitochondrial", "gene_name": "Mterf1", "organism": "Rat", "refseq_name": "transcription termination factor 1, mitochondrial", "refseq_ac": [ { "id": "NP_445951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445951", "type": "external" } ], "gene_names_uniprotkb": "Mterf1; Mterf", "gene_names_refseq": "Mterf1; Mterf", "protein_names_uniprotkb": "Transcription termination factor 1, mitochondrial; Mitochondrial transcription termination factor 1; mTERF", "protein_names_refseq": "transcription termination factor 1, mitochondrial; transcription termination factor, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:85261); (R-RNO-163316)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15087485", "class_list": "", "function": "The DNA-binding activity of mTERF is unaffected by the phosphorylation or dephosphorylation state, however, only the phosphorylated form of the protein is active for termination activity. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0003690 double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0006393 termination of mitochondrial transcription;GO:0006353 DNA-templated transcription termination;GO:0032392 DNA geometric change", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9EPI8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R189-1", "uniprot_id": [ { "id": "UN13D_RAT", "url": "https://www.uniprot.org/uniprot/Q9R189", "type": "external" } ], "mass": 123454.0, "length": 1088, "protein_name": "Protein unc-13 homolog D", "gene_name": "Unc13d", "organism": "Rat", "refseq_name": "protein unc-13 homolog D", "refseq_ac": [ { "id": "NP_620199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620199", "type": "external" } ], "gene_names_uniprotkb": "Unc13d; Unc13h4", "gene_names_refseq": "Munc13-4; Unc13d; Unc13h4", "protein_names_uniprotkb": "Protein unc-13 homolog D; Munc13-4", "protein_names_refseq": "contains two C2 domains; protein unc-13 homolog D", "tax_id": 10116, "disease": "familial hemophagocytic lymphohistiocytosis 3 (Disease Ontology:DOID:0110923)", "pathway": " (rno:192177); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10861235;15548590;21755595;22673903;26931073", "class_list": "", "function": "Munc13-4 is a direct partner of rab27a. The complex of the two proteins is an essential regulator of secretory granule fusion with the plasma membrane in hematopoietic cells. Mutations in either of the two genes prevent formation of this complex., [RefSeq, PubMed]; Novel Dutch founder mutation leads to severe early onset of FHL3 due to misfolding and degradation of munc13-4(1-899)., [RefSeq, PubMed]; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results suggest that Rab37 is a Munc13-4-binding protein that inhibits mast cell degranulation through its effector protein, by counteracting the vesicle-priming activity of the Rab27-Munc13-4 system Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0055037 recycling endosome;GO:0005764 lysosome;GO:0005770 late endosome", "go_biological_process": "GO:0002432 granuloma formation;GO:1903307 positive regulation of regulated secretory pathway;GO:0051607 defense response to virus;GO:0006909 phagocytosis;GO:1900026 positive regulation of substrate adhesion-dependent cell spreading", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9R189-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R103-1", "uniprot_id": [ { "id": "IL12A_RAT", "url": "https://www.uniprot.org/uniprot/Q9R103", "type": "external" } ], "mass": 24246.0, "length": 215, "protein_name": "Interleukin-12 subunit alpha", "gene_name": "Il12a", "organism": "Rat", "refseq_name": "interleukin-12 subunit alpha precursor", "refseq_ac": [ { "id": "NP_445842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445842", "type": "external" } ], "gene_names_uniprotkb": "Il12a; IL12A", "gene_names_refseq": "Il12a", "protein_names_uniprotkb": "Interleukin-12 subunit alpha; CLMF p35; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL-12 subunit p35; IL-12A", "protein_names_refseq": "CLMF p35; IL-12 subunit p35; IL-12A; cytotoxic lymphocyte maturation factor 35 kDa subunit; interleukin 12 p35 subunit; interleukin-12 subunit alpha precursor; interleukin-12 subunit alpha", "tax_id": 10116, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); hepatitis C (Disease Ontology:DOID:1883); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:84405); (R-RNO-8984722); (R-RNO-9020591)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "26994309", "class_list": "", "function": "Data show that endogenous interleukins IL-27 and IL-35 (Ebi3 and Il-12p35 subunits) had inflammatory roles and insulin like growth factor -1 (IGF-1) had no effect., [RefSeq, PubMed]; Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005143 interleukin-12 receptor binding;GO:0042163 interleukin-12 beta subunit binding;GO:0045513 interleukin-27 binding;GO:0046982 protein heterodimerization activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0043514 interleukin-12 complex;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0042022 interleukin-12 receptor complex", "go_biological_process": "GO:0032946 positive regulation of mononuclear cell proliferation;GO:0051142 positive regulation of NK T cell proliferation;GO:0035711 T-helper 1 cell activation;GO:0050709 negative regulation of protein secretion;GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9R103-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIM0-1", "uniprot_id": [ { "id": "MRE11_RAT", "url": "https://www.uniprot.org/uniprot/Q9JIM0", "type": "external" } ], "mass": 80122.0, "length": 706, "protein_name": "Double-strand break repair protein MRE11", "gene_name": "Mre11", "organism": "Rat", "refseq_name": "double-strand break repair protein MRE11", "refseq_ac": [ { "id": "NP_071615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071615", "type": "external" } ], "gene_names_uniprotkb": "Mre11; Mre11a", "gene_names_refseq": "Mre11a; Mre11", "protein_names_uniprotkb": "Double-strand break repair protein MRE11; 3.1.-.-; Double-strand break repair protein MRE11A; MRE11 homolog 1; MRE11 homolog A; Meiotic recombination 11 homolog 1; Meiotic recombination 11 homolog A", "protein_names_refseq": "MRE11 homolog 1; MRE11 homolog A, double strand break repair nuclease; MRE11 homolog, double strand break repair nuclease A; MRE11 meiotic recombination 11 homolog A; double-strand break repair protein MRE11A; double-strand break repair protein MRE11; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A", "tax_id": 10116, "disease": "ataxia-telangiectasia-like disorder 1 (Disease Ontology:DOID:0081384); intestinal cancer (Disease Ontology:DOID:10155); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); rectum cancer (Disease Ontology:DOID:1993); colon cancer (Disease Ontology:DOID:219); ovarian cancer (Disease Ontology:DOID:2394); malignant astrocytoma (Disease Ontology:DOID:3069); breast carcinoma (Disease Ontology:DOID:3459); liver cancer (Disease Ontology:DOID:3571); Lynch syndrome (Disease Ontology:DOID:3883); skin cancer (Disease Ontology:DOID:4159); stomach carcinoma (Disease Ontology:DOID:5517)", "pathway": " (rno:64046); (R-RNO-1834949); (R-RNO-2559586); (R-RNO-5685938); (R-RNO-5685939); (R-RNO-5685942); (R-RNO-5693537); (R-RNO-5693548); (R-RNO-5693565); (R-RNO-5693568); (R-RNO-5693571); (R-RNO-5693579); (R-RNO-5693607); (R-RNO-5693616); (R-RNO-6804756); (R-RNO-69473)", "pathway_count": 16, "publication_count": 2, "publication_id_list": "10908350;22673903", "class_list": "", "function": "Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation to create entry sites for EXO1- and DNA2-mediated 5' to 3' long-range resection, which is required for single-strand invasion and recombination. RBBP8/CtIP specifically promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends. MRE11 endonuclease activity is also enhanced by AGER/RAGE. The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR. The MRN complex is also required for the processing of R-loops (By similarity). The MRN complex is involved in the activation of the cGAS-STING pathway induced by DNA damage during tumorigenesis: the MRN complex acts by displacing CGAS from nucleosome sequestration, thereby activating it (By similarity). In telomeres the MRN complex may modulate t-loop formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0030145 manganese ion binding;GO:0042802 identical protein binding;GO:0004520 DNA endonuclease activity;GO:0008408 3'-5' exonuclease activity", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0016605 PML body", "go_biological_process": "GO:0007507 heart development;GO:0043066 negative regulation of apoptotic process;GO:0000723 telomere maintenance;GO:0006974 DNA damage response;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JIM0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4Z1-1", "uniprot_id": [ { "id": "SPA12_RAT", "url": "https://www.uniprot.org/uniprot/Q8R4Z1", "type": "external" } ], "mass": 47527.0, "length": 411, "protein_name": "Serpin A12", "gene_name": "Serpina12", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Serpina12", "gene_names_refseq": "", "protein_names_uniprotkb": "Serpin A12; Vaspin; Visceral adipose tissue-derived serine protease inhibitor; Visceral adipose-specific serpin", "protein_names_refseq": "", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:191570)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16030142", "class_list": "", "function": "Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0090181 regulation of cholesterol metabolic process;GO:0006006 glucose metabolic process;GO:0045721 negative regulation of gluconeogenesis;GO:0046628 positive regulation of insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R4Z1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESE2-1", "uniprot_id": [ { "id": "TNF11_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESE2", "type": "external" } ], "mass": 35370.0, "length": 318, "protein_name": "Tumor necrosis factor ligand superfamily member 11", "gene_name": "Tnfsf11", "organism": "Rat", "refseq_name": "tumor necrosis factor ligand superfamily member 11", "refseq_ac": [ { "id": "NP_476490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476490", "type": "external" } ], "gene_names_uniprotkb": "Tnfsf11; Opgl; Rankl; Trance", "gene_names_refseq": "ODF; OPGL; RANKL; TRANCE; Tnfsf11", "protein_names_uniprotkb": "Tumor necrosis factor ligand superfamily member 11; ODF; OPGL; Osteoclast differentiation factor; Osteoprotegerin ligand; RANKL; Receptor activator of nuclear factor kappa-B ligand; TNF-related activation-induced cytokine; TRANCE", "protein_names_refseq": "TNF-related activation-induced cytokine; osteoclast differentiation factor; osteoprotegerin ligand; receptor activator of nuclear factor kappa-B ligand; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand superfamily member 11; tumor necrosis factor superfamily member 11", "tax_id": 10116, "disease": "autosomal recessive osteopetrosis 2 (Disease Ontology:DOID:0110943); osteoporosis (Disease Ontology:DOID:11476); mucopolysaccharidosis VI (Disease Ontology:DOID:12800); myocardial infarction (Disease Ontology:DOID:5844); myocarditis (Disease Ontology:DOID:820); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:117516); (R-RNO-5668541); (R-RNO-5669034); (R-RNO-5676594); (R-RNO-9856649)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "11092398;11804028;34946658;34948030;35842599;36054965;38923421", "class_list": "", "function": "Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an experimental rat apical periodontitis model., [RefSeq, PubMed]; Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation., [UniProtKB, UniProtKB, UniProtKB]; Mechanical force regulates root resorption in rats through RANKL and OPG. Publication Status: Online-Only, [RefSeq, PubMed]; RANKL down-regulates the mast cell proliferation through inducing senescence., [RefSeq, PubMed]; The Influence of Prenatal Fumonisin Exposure on Bone Properties, as well as OPG and RANKL Expression and Immunolocalization, in Newborn Offspring Is Sex and Dose Dependent. Publication Status: Online-Only, [RefSeq, PubMed]; The toothless (tl) osteopetrotic rat mutation is not in the TNFSF11 locus, [RefSeq, PubMed]; Yukmijihwang-Tang Suppresses Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL)-Induced Osteoclast Differentiation and Prevents Ovariectomy (OVX)-Mediated Bone Loss. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91ZI9", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity;GO:0032813 tumor necrosis factor receptor superfamily binding;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:2001206 positive regulation of osteoclast development;GO:0071812 positive regulation of fever generation by positive regulation of prostaglandin secretion;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ESE2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERS8-1", "uniprot_id": [ { "id": "SEBOX_RAT", "url": "https://www.uniprot.org/uniprot/Q9ERS8", "type": "external" } ], "mass": 20196.0, "length": 188, "protein_name": "Homeobox protein SEBOX", "gene_name": "Sebox", "organism": "Rat", "refseq_name": "homeobox protein SEBOX", "refseq_ac": [ { "id": "NP_076441", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076441", "type": "external" } ], "gene_names_uniprotkb": "Sebox; Og9x", "gene_names_refseq": "Og9x; Sebox", "protein_names_uniprotkb": "Homeobox protein SEBOX; Homeobox OG-9; Skin-, embryo-, brain- and oocyte-specific homeobox", "protein_names_refseq": "OG9 homeobox; homeobox OG-9; homeobox protein SEBOX; skin-, embryo-, brain- and oocyte-specific homeobox", "tax_id": 10116, "disease": "", "pathway": " (rno:58922)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10922053", "class_list": "", "function": "Probable transcription factor involved in the control of specification of mesoderm and endoderm., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0006351 DNA-templated transcription;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9ERS8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQM4-1", "uniprot_id": [ { "id": "SOAT2_RAT", "url": "https://www.uniprot.org/uniprot/Q7TQM4", "type": "external" } ], "mass": 60498.0, "length": 524, "protein_name": "Sterol O-acyltransferase 2", "gene_name": "Soat2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Soat2; Acat2", "gene_names_refseq": "", "protein_names_uniprotkb": "Sterol O-acyltransferase 2; 2.3.1.26; ACAT-2; Acyl-coenzyme A:cholesterol acyltransferase 2; Cholesterol acyltransferase 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "nephrotic syndrome (Disease Ontology:DOID:1184); coronary artery disease (Disease Ontology:DOID:3393); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:266770); (R-RNO-8964038)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.26", "type": "external" } ], "go_molecular_function": "GO:0015485 cholesterol binding;GO:0000062 fatty-acyl-CoA binding;GO:0004772 sterol O-acyltransferase activity;GO:0034736 cholesterol O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005903 brush border;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007584 response to nutrient;GO:0008203 cholesterol metabolic process;GO:0033344 cholesterol efflux;GO:0034379 very-low-density lipoprotein particle assembly;GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7TQM4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLZ9-1", "uniprot_id": [ { "id": "VAX2_RAT", "url": "https://www.uniprot.org/uniprot/Q9JLZ9", "type": "external" } ], "mass": 31706.0, "length": 292, "protein_name": "Ventral anterior homeobox 2", "gene_name": "Vax2", "organism": "Rat", "refseq_name": "ventral anterior homeobox 2", "refseq_ac": [ { "id": "NP_072159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072159", "type": "external" } ], "gene_names_uniprotkb": "Vax2", "gene_names_refseq": "Vax2", "protein_names_uniprotkb": "Ventral anterior homeobox 2", "protein_names_refseq": "ventral anterior homeobox 2; ventral anterior homeobox containing gene 2", "tax_id": 10116, "disease": "", "pathway": " (rno:64572)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0031490 chromatin DNA binding;GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007409 axonogenesis;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9JLZ9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI12-1", "uniprot_id": [ { "id": "VGLU2_RAT", "url": "https://www.uniprot.org/uniprot/Q9JI12", "type": "external" } ], "mass": 64576.0, "length": 582, "protein_name": "Vesicular glutamate transporter 2", "gene_name": "Slc17a6", "organism": "Rat", "refseq_name": "vesicular glutamate transporter 2", "refseq_ac": [ { "id": "NP_445879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445879", "type": "external" } ], "gene_names_uniprotkb": "Slc17a6; Dnpi; Vglut2", "gene_names_refseq": "Dnpi; Slc17a6; Vglut2", "protein_names_uniprotkb": "Vesicular glutamate transporter 2; Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6; VGluT2", "protein_names_refseq": "differentation-associated Na-dependent inorganic phosphate cotransporter; differentiation-associated BNPI; differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; solute carrier family 17 (vesicular glutamate transporter), member 6; vesicular glutamate transporter 2", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (rno:84487); (R-RNO-442660)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "11502256;11551935;11698619;11698620;17046815;17110340;18080752;25433636;27133463;29642010;32439795;33550485;34321562;35933616;36085433;38194067", "class_list": "", "function": "Changes in vesicular glutamate transporter 2 (Vglut2) and vesicular GABA transporter 1 (Vgat1) in the orofacial pain and temperature perception pathway under low estrogen conditions., [RefSeq, PubMed]; DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study. Publication Status: Online-Only, [RefSeq, PubMed]; Developmental light deprivation transiently reduces the expression of vGluT2 and GluN2B in the rat ventral suprachiasmatic nucleus., [RefSeq, PubMed]; Expression of GAD65/67 and VGLUT2 in Mediobasal Nuclei of Rat Hypothalamus during Aging., [RefSeq, PubMed]; GluN2A- and GluN2B-immunoreactive type I cells attached to vesicular glutamate transporter 2-immunoreactive afferent nerve terminals of the rat carotid body., [RefSeq, PubMed]; Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:11502256, PubMed:11551935, PubMed:11698619, PubMed:17046815, PubMed:18080752, PubMed:25433636, PubMed:27133463, PubMed:29642010, PubMed:32439795). At the synaptic vesicle membrane, mainly functions as a uniporter which transports preferentially L-glutamate but also, phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:11502256, PubMed:11551935, PubMed:11698619, PubMed:17046815, PubMed:18080752, PubMed:27133463, PubMed:29642010, PubMed:32439795). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed:11502256, PubMed:11551935, PubMed:11698619, PubMed:17046815, PubMed:29642010, PubMed:32439795). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane therefore affects the proton electrochemical gradient and promotes synaptic vesicles acidification (PubMed:27133463). Moreover, functions as a vesicular K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular L-glutamate uptake (PubMed:25433636). The vesicular H(+)/H(+) antiport activity is electroneutral (PubMed:25433636). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (PubMed:17046815, PubMed:29642010). The symporter activity is driven by an inside negative membrane potential and is electrogenic (PubMed:17046815, PubMed:29642010). Also involved in the regulation of retinal hyaloid vessel regression during postnatal development (By similarity). May also play a role in the endocrine L-glutamatergic system of other tissues such as pineal gland and pancreas (PubMed:11551935)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015386 potassium:proton antiporter activity;GO:0005254 chloride channel activity;GO:0005313 L-glutamate transmembrane transporter activity;GO:0005436 sodium:phosphate symporter activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0030672 synaptic vesicle membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:1990384 hyaloid vascular plexus regression;GO:0003407 neural retina development;GO:0050803 regulation of synapse structure or activity;GO:0021766 hippocampus development;GO:0035249 synaptic transmission, glutamatergic", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9JI12-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJS5-1", "uniprot_id": [ { "id": "SH3B4_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJS5", "type": "external" } ], "mass": 107513.0, "length": 961, "protein_name": "SH3 domain-binding protein 4", "gene_name": "Sh3bp4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sh3bp4", "gene_names_refseq": "", "protein_names_uniprotkb": "SH3 domain-binding protein 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:64634); (R-RNO-9639288)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031267 small GTPase binding;GO:0005092 GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005905 clathrin-coated pit;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0006897 endocytosis;GO:0008285 negative regulation of cell population proliferation;GO:0050790 regulation of catalytic activity;GO:0030308 negative regulation of cell growth;GO:0010508 positive regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JJS5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4V4-1", "uniprot_id": [ { "id": "SNX27_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4V4", "type": "external" } ], "mass": 61015.0, "length": 539, "protein_name": "Sorting nexin-27", "gene_name": "Snx27", "organism": "Rat", "refseq_name": "sorting nexin-27 isoform a", "refseq_ac": [ { "id": "NP_001103621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103621", "type": "external" } ], "gene_names_uniprotkb": "Snx27; Mrt1", "gene_names_refseq": "Mrt1; Snx27", "protein_names_uniprotkb": "Sorting nexin-27; MAP-responsive gene protein; Methamphetamine-responsive transcript 1 protein; PDZ-protein Mrt1", "protein_names_refseq": "MAP-responsive gene protein; PDZ-protein Mrt1; methamphetamine (MAP) responsive transcript 1; methamphetamine-responsive transcript 1 protein; sorting nexin family member 27; sorting nexin-27 isoform a", "tax_id": 10116, "disease": "", "pathway": " (rno:260323)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12740601;12774298;17351151;17828261;18690037;21422294;22673903;26538661;30602588;31775031;32413996", "class_list": "", "function": "Gene is developmentally regulated and stimulated by methamphetamine in the neocortex., [RefSeq, PubMed]; Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SNX27 promotes the endosomal movement of Kir3 (GIRK) channels, leading to reduced surface expression, increased degradation and smaller Kir3 potassium currents., [RefSeq, PubMed]; SNX27-Mediated Recycling of Neuroligin-2 Regulates Inhibitory Signaling., [RefSeq, PubMed]; Sorting Nexin 27 Regulates the Lysosomal Degradation of Aquaporin-2 Protein in the Kidney Collecting Duct. Publication Status: Online-Only, [RefSeq, PubMed]; The regulation of the VPS26A-SNX27 interaction modifies mGluR5 trafficking which mediates neuropathic pain., [RefSeq, PubMed]; These data indicate that NLGs are SNX27-retromer cargoes and suggest that SNX27-retromer controls inhibitory synapse number, at least in part through trafficking of NLG2. Publication Status: Online-Only, [RefSeq, PubMed]; These findings suggest the differential regulation by stimulant of neocortical mrt1 expression and supports the view that stimulant induction of mrt1 may be involved in the early molecular signalings for stimulant sensitization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4T6", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0035091 phosphatidylinositol binding;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098837 postsynaptic recycling endosome;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:1903609 negative regulation of inward rectifier potassium channel activity;GO:0006886 intracellular protein transport;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:1990090 cellular response to nerve growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8K4V4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNZ6-1", "uniprot_id": [ { "id": "STRAA_RAT", "url": "https://www.uniprot.org/uniprot/Q7TNZ6", "type": "external" } ], "mass": 43553.0, "length": 393, "protein_name": "STE20-related kinase adapter protein alpha", "gene_name": "Strada", "organism": "Rat", "refseq_name": "STE20-related kinase adapter protein alpha isoform 2", "refseq_ac": [ { "id": "NP_877972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_877972", "type": "external" } ], "gene_names_uniprotkb": "Strada; Lyk5; Strad", "gene_names_refseq": "Lyk5; Strada", "protein_names_uniprotkb": "STE20-related kinase adapter protein alpha; STE20-related adapter protein; STRAD alpha", "protein_names_refseq": "STE20-related adapter protein; STE20-related kinase adapter protein alpha isoform 2; STE20-related kinase adapter protein alpha; STE20-related kinase adaptor alpha; STRAD alpha; protein kinase LYK5", "tax_id": 10116, "disease": "polyhydramnios, megalencephaly, and symptomatic epilepsy (Disease Ontology:DOID:0070511); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:303605); (R-RNO-380972)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "14511394;17482549;18687677", "class_list": "", "function": "LKB1 deacetylation is regulated by SIRT1 and that this in turn influences its intracellular localization, association with STRAD, kinase activity, and ability to activate AMPK., [RefSeq, PubMed]; Local LKB1/STRAD accumulation and PKA-dependent LKB1 phosphorylation represents an early signal for axon initiation [STRAD protein], [RefSeq, PubMed]; Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66HD4", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0030295 protein kinase activator activity;GO:0019900 kinase binding;GO:0044877 protein-containing complex binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0032147 activation of protein kinase activity;GO:0006611 protein export from nucleus;GO:0070314 G1 to G0 transition", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TNZ6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6YAT4-1", "uniprot_id": [ { "id": "SGCE_RAT", "url": "https://www.uniprot.org/uniprot/Q6YAT4", "type": "external" } ], "mass": 49840.0, "length": 437, "protein_name": "Epsilon-sarcoglycan", "gene_name": "Sgce", "organism": "Rat", "refseq_name": "epsilon-sarcoglycan", "refseq_ac": [ { "id": "NP_001002023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002023", "type": "external" } ], "gene_names_uniprotkb": "Sgce", "gene_names_refseq": "Sgce", "protein_names_uniprotkb": "Epsilon-sarcoglycan; Epsilon-SG", "protein_names_refseq": "epsilon-SG; epsilon-sarcoglycan", "tax_id": 10116, "disease": "myoclonic dystonia 11 (Disease Ontology:DOID:0090034); stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (rno:432360); (R-RNO-9913351)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14625080;22894000", "class_list": "", "function": "Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In cerebellar neurons and glial cells alpha-, beta-, gamma-, delta-, and epsilon-sarcoglycans are all expressed., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0001822 kidney development;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6YAT4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4V0-1", "uniprot_id": [ { "id": "SGK3_RAT", "url": "https://www.uniprot.org/uniprot/Q8R4V0", "type": "external" } ], "mass": 57171.0, "length": 496, "protein_name": "Serine/threonine-protein kinase Sgk3", "gene_name": "Sgk3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sgk3; Cisk; Sgkl", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase Sgk3; 2.7.11.1; Cytokine-independent survival kinase; Serum/glucocorticoid-regulated kinase 3; Serum/glucocorticoid-regulated kinase-like", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:171498); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15504348", "class_list": "", "function": "Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0015459 potassium channel regulator activity;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005769 early endosome;GO:0055037 recycling endosome;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R4V0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHM9-1", "uniprot_id": [ { "id": "TEDM1_RAT", "url": "https://www.uniprot.org/uniprot/Q8CHM9", "type": "external" } ], "mass": 34865.0, "length": 305, "protein_name": "Transmembrane epididymal protein 1", "gene_name": "Teddm1a; Teddm1", "organism": "Rat", "refseq_name": "transmembrane epididymal protein 1", "refseq_ac": [ { "id": "NP_001035004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035004", "type": "external" } ], "gene_names_uniprotkb": "Teddm1a; Teddm1; Teddm1", "gene_names_refseq": "Teddm1a; Teddm1", "protein_names_uniprotkb": "Transmembrane epididymal protein 1", "protein_names_refseq": "transmembrane epididymal protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:664710)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CHM9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N01-1", "uniprot_id": [ { "id": "SO4A1_RAT", "url": "https://www.uniprot.org/uniprot/Q99N01", "type": "external" } ], "mass": 77634.0, "length": 723, "protein_name": "Solute carrier organic anion transporter family member 4A1", "gene_name": "Slco4a1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slco4a1; Oatp4a1; Oatpe; Slc21a12", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 4A1; OATP-E; Organic anion-transporting polypeptide E; Sodium-independent organic anion transporter E; Solute carrier family 21 member 12", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:171144); (R-RNO-879518)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11316767", "class_list": "", "function": "Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner (By similarity) (PubMed:11316767). May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (By similarity). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015349 thyroid hormone transmembrane transporter activity;GO:0015132 prostaglandin transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0030054 cell junction;GO:0005886 plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0043252 sodium-independent organic anion transport;GO:0042403 thyroid hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99N01-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXR5-1", "uniprot_id": [ { "id": "S35A3_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXR5", "type": "external" } ], "mass": 36079.0, "length": 326, "protein_name": "UDP-N-acetylglucosamine transporter", "gene_name": "Slc35a3; Slc71a1", "organism": "Rat", "refseq_name": "UDP-N-acetylglucosamine transporter", "refseq_ac": [ { "id": "NP_001012082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012082", "type": "external" } ], "gene_names_uniprotkb": "Slc35a3; Slc71a1; Mfsd14a; NEWGENE_1305281", "gene_names_refseq": "Slc35a3", "protein_names_uniprotkb": "UDP-N-acetylglucosamine transporter; Golgi UDP-GlcNAc transporter; Solute carrier family 35 member A3", "protein_names_refseq": "UDP-N-acetylglucosamine transporter; golgi UDP-GlcNAc transporter; solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3", "tax_id": 10116, "disease": "", "pathway": " (rno:310808); (R-RNO-727802)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable membrane-bound transporter. May play a role in neuronal nutrient sensing and energy homeostasis. Required for the final stages of spermatogenesis., [UniProtKB, UniProtKB]; Transports diphosphate-N-acetylglucosamine (UDP-GlcNAc) from the cytosol into the lumen of the Golgi apparatus, functioning as an antiporter that exchanges UDP-N-acetyl-alpha-D-glucosamine for UMP. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate highly branched, multiantennary complex N-glycans and keratan sulfate. However, the exact role of SLC35A3 still needs to be elucidated, it could be a member of a catalytically more efficient multiprotein complex rather than function independently as a single transporter., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0005459 UDP-galactose transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0055085 transmembrane transport;GO:1990569 UDP-N-acetylglucosamine transmembrane transport;GO:0030382 sperm mitochondrion organization;GO:0007283 spermatogenesis;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXR5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXU7-1", "uniprot_id": [ { "id": "MI4GD_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXU7", "type": "external" } ], "mass": 25471.0, "length": 222, "protein_name": "MIF4G domain-containing protein", "gene_name": "Mif4gd", "organism": "Rat", "refseq_name": "MIF4G domain-containing protein", "refseq_ac": [ { "id": "NP_001014144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014144", "type": "external" } ], "gene_names_uniprotkb": "Mif4gd", "gene_names_refseq": "Mif4gd; RGD1309685", "protein_names_uniprotkb": "MIF4G domain-containing protein", "protein_names_refseq": "MIF4G domain-containing protein", "tax_id": 10116, "disease": "", "pathway": " (rno:360659)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21157122", "class_list": "", "function": "Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation (By similarity)., [UniProtKB]; May function as a translational regulator in spermiogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0008494 translation activator activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0062073 histone mRNA stem-loop binding complex", "go_biological_process": "GO:0006446 regulation of translational initiation;GO:0002191 cap-dependent translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXU7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXX4-1", "uniprot_id": [ { "id": "SAS10_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXX4", "type": "external" } ], "mass": 53924.0, "length": 470, "protein_name": "Something about silencing protein 10", "gene_name": "Mgst3l1; Mgst3; Utp3", "organism": "Rat", "refseq_name": "something about silencing protein 10", "refseq_ac": [ { "id": "NP_001012036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012036", "type": "external" } ], "gene_names_uniprotkb": "Mgst3l1; Mgst3; Utp3; Crlz1; Mgst3l1; RGD1561381; Sas10; Utp3", "gene_names_refseq": "Crlz1; Utp3", "protein_names_uniprotkb": "Something about silencing protein 10; Charged amino acid-rich leucine zipper 1; Disrupter of silencing SAS10; UTP3 homolog", "protein_names_refseq": "UTP3 homolog; UTP3, small subunit processome component homolog; charged amino acid-rich leucine zipper 1; disrupter of silencing SAS10; something about silencing protein 10", "tax_id": 10116, "disease": "", "pathway": " (rno:289197); (rno:305258); (rno:498340); (R-RNO-156590); (R-RNO-5423646); (R-RNO-6791226)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "22673903;29393594;38843836", "class_list": "", "function": "Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.11.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0004464 leukotriene-C4 synthase activity;GO:0042802 identical protein binding;GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0032040 small-subunit processome;GO:0005635 nuclear envelope;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0007420 brain development;GO:0006325 chromatin organization;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6AXX4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY22-1", "uniprot_id": [ { "id": "SPAT1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY22", "type": "external" } ], "mass": 51099.0, "length": 444, "protein_name": "Spermatogenesis-associated protein 1", "gene_name": "Spata1", "organism": "Rat", "refseq_name": "spermatogenesis-associated protein 1", "refseq_ac": [ { "id": "NP_001014199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014199", "type": "external" } ], "gene_names_uniprotkb": "Spata1", "gene_names_refseq": "Spata1", "protein_names_uniprotkb": "Spermatogenesis-associated protein 1", "protein_names_refseq": "spermatogenesis-associated protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:362056)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031410 cytoplasmic vesicle;GO:0001669 acrosomal vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY22-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY59-1", "uniprot_id": [ { "id": "MOC2B_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY59", "type": "external" } ], "mass": 22233.0, "length": 200, "protein_name": "Molybdopterin synthase catalytic subunit", "gene_name": "Mocs2", "organism": "Rat", "refseq_name": "molybdopterin synthase catalytic subunit isoform Mocs2B-1", "refseq_ac": [ { "id": "NP_001007634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007634", "type": "external" } ], "gene_names_uniprotkb": "Mocs2; MOCS2", "gene_names_refseq": "Mocs2", "protein_names_uniprotkb": "Molybdopterin synthase catalytic subunit; 2.8.1.12; MOCS2B; Molybdenum cofactor synthesis protein 2 large subunit; Molybdenum cofactor synthesis protein 2B", "protein_names_refseq": "MOCS2B; molybdenum cofactor synthesis protein 2 large subunit; molybdenum cofactor synthesis protein 2B; molybdopterin synthase catalytic subunit isoform Mocs2B-1; molybdopterin synthase catalytic subunit; molybdopterin synthase sulfur carrier subunit", "tax_id": 10116, "disease": "molybdenum cofactor deficiency type B (Disease Ontology:DOID:0111163)", "pathway": " (rno:294753)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group (By similarity). Together with MBIP, inhibits the activity of stress kinase EIF2AK2/PKR; this may suppress JNK activation and subsequent stress-responsive transcription, or suppress eIF2a phosphorylation to favor translation (By similarity)., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.12", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030366 molybdopterin synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:1990140 molybdopterin synthase complex", "go_biological_process": "GO:0006777 Mo-molybdopterin cofactor biosynthetic process;GO:0032324 molybdopterin cofactor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY59-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYB3-1", "uniprot_id": [ { "id": "ISY1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYB3", "type": "external" } ], "mass": 32861.0, "length": 284, "protein_name": "Pre-mRNA-splicing factor ISY1 homolog", "gene_name": "Isy1", "organism": "Rat", "refseq_name": "pre-mRNA-splicing factor ISY1 homolog", "refseq_ac": [ { "id": "NP_001014210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014210", "type": "external" } ], "gene_names_uniprotkb": "Isy1", "gene_names_refseq": "Isy1-rab43; Isy1; RGD1307688", "protein_names_uniprotkb": "Pre-mRNA-splicing factor ISY1 homolog", "protein_names_refseq": "ISY1 splicing factor homolog; ISY1-RAB43 readthrough; pre-mRNA-splicing factor ISY1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:362394); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-72163)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (By similarity). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity). Required during the transition of embryonic stem cells (ESCs) from the naive to primed state (By similarity). By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes transition to the primed state (By similarity). Involved in pre-mRNA splicing as component of the spliceosome., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071014 post-mRNA release spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000350 generation of catalytic spliceosome for second transesterification step;GO:0000389 mRNA 3'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYB3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYC2-1", "uniprot_id": [ { "id": "IRGM_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYC2", "type": "external" } ], "mass": 46338.0, "length": 411, "protein_name": "Immunity-related GTPase family M protein", "gene_name": "Irgm", "organism": "Rat", "refseq_name": "immunity-related GTPase family M protein", "refseq_ac": [ { "id": "NP_001012007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012007", "type": "external" } ], "gene_names_uniprotkb": "Irgm", "gene_names_refseq": "Ifggd3; Ifi1; Irgm", "protein_names_uniprotkb": "Immunity-related GTPase family M protein; 3.6.5.-", "protein_names_refseq": "immunity-related GTPase family M protein; immunity-related GTPase family, M; interferon inducible protein 1; interferon-gamma-inducible GTPase Ifggd3 protein", "tax_id": 10116, "disease": "inflammatory bowel disease 19 (Disease Ontology:DOID:0110890); tuberculosis (Disease Ontology:DOID:399)", "pathway": " (rno:303090)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Immunity-related GTPase that plays important roles in innate immunity and inflammatory response (By similarity). Acts as a dynamin-like protein that binds to intracellular membranes and promotes remodeling and trafficking of those membranes (By similarity). Required for clearance of acute protozoan and bacterial infections by interacting with autophagy and lysosome regulatory proteins, thereby promoting the fusion of phagosomes with lysosomes for efficient degradation of cargo including microbes (By similarity). Regulates selective autophagy, including xenophagy and mitophagy, both directly and indirectly (By similarity). Directly regulates autophagy by acting as a molecular adapter that promotes the coassembly of the core autophagy machinery to mediate antimicrobial defense: Irgm (1) activates AMPK, which in turn phosphorylates ULK1 and BECN1 to induce autophagy, (2) promotes the coassembly of ULK1 and BECN1, enhancing BECN1-interacting partners and (3) influences the composition of the BECN1 complex, by competing with the negative regulators BCL2 and RUBCN, to trigger autophagy (By similarity). Also activates autophagy by promoting recruitment of STX17 to autophagosomes (By similarity). In collaboration with ATG8 proteins, regulate lysosomal biogenesis, a fundamental process for any autophagic pathway, by promoting TFEB dephosphorylation (By similarity). Also modulates autophagy by assisting with autophagosome formation and preventing lysosomal deacidification (By similarity). Regulates autophagy by affecting mitochondrial fusion and fission (By similarity). Also involved in M1 macrophage activation for the production of proinflammatory cytokines (By similarity). While activating autophagy, acts as a key negative regulator of the inflammatory and interferon responses both by (1) promoting mitophagy and (2) mediating autophagy-dependent degradation of effectors of the inflammatory response (By similarity). Promotes degradation of damaged and IFNG/IFN-gamma-stressed mitochondria via mitophagy, preventing cytosolic release of ligands that activate inflammation (By similarity). Negatively regulates interferon-signaling in hematopoietic stem cells, preserving hematopoietic stem cell number and function (By similarity). Promotes expansion of activated CD4(+) T-cells by inhibiting IFNG/IFN-gamma signaling, thereby preventing Ifng-mediated cell death of CD4(+) T-cells (By similarity). Acts as a suppressor of inflammation by promoting recruitment of inflammation effectors, such as CGAS, RIGI/RIG-I and NLRP3, to autophagosome membranes, leading to their SQSTM1/p62-dependent autophagic degradation (By similarity). Also directly inhibits assembly of the NLRP3 inflammasome by preventing the association between NLRP3 and PYCARD (By similarity). Acts as a negative regulator of antiviral innate immune response by suppressing the RIPK2-dependent pro-inflammatory response: mediates recruitment of RIPosomes, composed of RIPK2 and NOD1 or NOD2, to autophagosome membranes, promoting their SQSTM1/p62-dependent autophagic degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0001891 phagocytic cup;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0043032 positive regulation of macrophage activation;GO:0090140 regulation of mitochondrial fission;GO:1901526 positive regulation of mitophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYC2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYC8-1", "uniprot_id": [ { "id": "SH24A_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYC8", "type": "external" } ], "mass": 48522.0, "length": 422, "protein_name": "SH2 domain-containing protein 4A", "gene_name": "Sh2d4a", "organism": "Rat", "refseq_name": "SH2 domain-containing protein 4A", "refseq_ac": [ { "id": "NP_001012048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012048", "type": "external" } ], "gene_names_uniprotkb": "Sh2d4a", "gene_names_refseq": "Sh2d4a", "protein_names_uniprotkb": "SH2 domain-containing protein 4A", "protein_names_refseq": "SH2 domain-containing protein 4A", "tax_id": 10116, "disease": "", "pathway": " (rno:306376)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYC8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYF1-1", "uniprot_id": [ { "id": "SIN1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYF1", "type": "external" } ], "mass": 59043.0, "length": 522, "protein_name": "Target of rapamycin complex 2 subunit MAPKAP1", "gene_name": "Mapkap1", "organism": "Rat", "refseq_name": "target of rapamycin complex 2 subunit MAPKAP1", "refseq_ac": [ { "id": "NP_001011964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011964", "type": "external" } ], "gene_names_uniprotkb": "Mapkap1; Sin1", "gene_names_refseq": "Mapkap1", "protein_names_uniprotkb": "Target of rapamycin complex 2 subunit MAPKAP1; SAPK-interacting protein 1; Stress-activated map kinase-interacting protein 1; TORC2 subunit MAPKAP1", "protein_names_refseq": "SAPK-interacting protein 1; TORC2 subunit MAPKAP1; mitogen-activated protein kinase 2-associated protein 1; mitogen-activated protein kinase associated protein 1; stress-activated map kinase-interacting protein 1; target of rapamycin complex 2 subunit MAPKAP1-like; target of rapamycin complex 2 subunit MAPKAP1", "tax_id": 10116, "disease": "", "pathway": " (rno:296648); (R-RNO-1257604); (R-RNO-389357); (R-RNO-5218920); (R-RNO-6804757); (R-RNO-9856530)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (By similarity). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (By similarity). In contrast to mTORC1, mTORC2 is nutrient-insensitive (By similarity). Within the mTORC2 complex, MAPKAP1/SIN1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by MTOR (By similarity). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (By similarity). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (By similarity). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (By similarity). MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation (By similarity). Inhibits HRAS and KRAS independently of mTORC2 complex (By similarity). Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription (By similarity). Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0019901 protein kinase binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0032869 cellular response to insulin stimulus;GO:0033138 positive regulation of peptidyl-serine phosphorylation;GO:1900407 regulation of cellular response to oxidative stress;GO:0038203 TORC2 signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYF1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYH0-1", "uniprot_id": [ { "id": "MIIP_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYH0", "type": "external" } ], "mass": 43339.0, "length": 389, "protein_name": "Migration and invasion-inhibitory protein", "gene_name": "Miip", "organism": "Rat", "refseq_name": "migration and invasion-inhibitory protein", "refseq_ac": [ { "id": "NP_001017450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017450", "type": "external" } ], "gene_names_uniprotkb": "Miip; Iip45", "gene_names_refseq": "Iip45; Miip", "protein_names_uniprotkb": "Migration and invasion-inhibitory protein; IIp45; Invasion-inhibitory protein 45", "protein_names_refseq": "IGFBP-2-Binding Protein, IIp45; invasion-inhibitory protein 45; migration and invasion-inhibitory protein-like; migration and invasion-inhibitory protein", "tax_id": 10116, "disease": "", "pathway": " (rno:298643)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0030336 negative regulation of cell migration;GO:0010972 negative regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYH0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYI5-1", "uniprot_id": [ { "id": "SHOC2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYI5", "type": "external" } ], "mass": 64921.0, "length": 582, "protein_name": "Leucine-rich repeat protein SHOC-2", "gene_name": "Shoc2", "organism": "Rat", "refseq_name": "leucine-rich repeat protein SHOC-2", "refseq_ac": [ { "id": "NP_001013173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013173", "type": "external" } ], "gene_names_uniprotkb": "Shoc2", "gene_names_refseq": "Shoc2", "protein_names_uniprotkb": "Leucine-rich repeat protein SHOC-2; Protein soc-2 homolog; Protein sur-8 homolog", "protein_names_refseq": "leucine-rich repeat protein SHOC-2; protein soc-2 homolog; protein sur-8 homolog; soc-2 (suppressor of clear) homolog", "tax_id": 10116, "disease": "RASopathy (Disease Ontology:DOID:0080690); Noonan syndrome-like disorder with loose anagen hair (Disease Ontology:DOID:0080691); Noonan syndrome-like disorder with loose anagen hair 1 (Disease Ontology:DOID:0080692); atopic dermatitis (Disease Ontology:DOID:3310)", "pathway": " (rno:309548); (R-RNO-5673000)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21732489", "class_list": "", "function": "Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway (By similarity). Acts as a scaffolding protein in the SMP complex (By similarity). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (By similarity). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (By similarity). Acts as an inhibitor of keratinocyte differentiation via interaction with RAS protein complexes that promote ERK activation (By similarity)., [UniProtKB, UniProtKB]; Sur8 is an antidifferentiation factor that stimulates proliferation for maintenance of self-renewal in NPCs via modulation of the Ras-ERK pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008157 protein phosphatase 1 binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0071378 cellular response to growth hormone stimulus;GO:0010976 positive regulation of neuron projection development;GO:0035556 intracellular signal transduction;GO:0045665 negative regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYI5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYK3-1", "uniprot_id": [ { "id": "INO1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYK3", "type": "external" } ], "mass": 60884.0, "length": 557, "protein_name": "Inositol-3-phosphate synthase 1", "gene_name": "Isyna1", "organism": "Rat", "refseq_name": "inositol-3-phosphate synthase 1", "refseq_ac": [ { "id": "NP_001013902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013902", "type": "external" } ], "gene_names_uniprotkb": "Isyna1; Ino1", "gene_names_refseq": "Isyna1", "protein_names_uniprotkb": "Inositol-3-phosphate synthase 1; 5.5.1.4; IPS 1; MI-1-P synthase; MIP synthase; Myo-inositol 1-phosphate synthase", "protein_names_refseq": "IPS 1; MI-1-P synthase; MIP synthase; inositol-3-phosphate synthase 1; myo-inositol 1-phosphate synthase A1; myo-inositol-1-phosphate synthase", "tax_id": 10116, "disease": "acquired metabolic disease (Disease Ontology:DOID:0060158); azoospermia (Disease Ontology:DOID:14227)", "pathway": " (rno:290651); (R-RNO-1855183)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "19188364;21841945;23504145;29393594;6773943;885873", "class_list": "", "function": "Competitively inhibits the function of isoform 1, presumably by competing for NAD cofactor., [UniProtKB, PubMed]; Differential phosphorylation of IPS isoforms in brain, intestine and testis suggests novel functions in these tissues., [RefSeq, PubMed]; Isyna1 is regulated, in part, by DNA methylation and that significant alterations in methylation patterns during development could have a major impact on inositol phosphate synthase expression in later life., [RefSeq, PubMed]; Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.5.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.5.1.4", "type": "external" } ], "go_molecular_function": "GO:0004512 inositol-3-phosphate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006021 inositol biosynthetic process;GO:0008654 phospholipid biosynthetic process;GO:1900089 negative regulation of inositol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6AYK3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYL5-1", "uniprot_id": [ { "id": "SF3B4_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYL5", "type": "external" } ], "mass": 44356.0, "length": 424, "protein_name": "Splicing factor 3B subunit 4", "gene_name": "Sf3b4", "organism": "Rat", "refseq_name": "splicing factor 3B subunit 4", "refseq_ac": [ { "id": "NP_001011951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011951", "type": "external" } ], "gene_names_uniprotkb": "Sf3b4", "gene_names_refseq": "Sf3b4", "protein_names_uniprotkb": "Splicing factor 3B subunit 4", "protein_names_refseq": "splicing factor 3B subunit 4", "tax_id": 10116, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); cervical cancer (Disease Ontology:DOID:4362); Nager acrofacial dysostosis (Disease Ontology:DOID:5768); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:295270); (R-RNO-72163); (R-RNO-72165); (R-RNO-9770562); (R-RNO-9943411)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B4 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:1990935 splicing factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005681 spliceosomal complex;GO:0005686 U2 snRNP;GO:0071011 precatalytic spliceosome;GO:0071006 U2-type catalytic step 1 spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYL5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYP4-1", "uniprot_id": [ { "id": "ZC21C_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYP4", "type": "external" } ], "mass": 59450.0, "length": 525, "protein_name": "Zinc finger C2HC domain-containing protein 1C", "gene_name": "Zc2hc1c", "organism": "Rat", "refseq_name": "zinc finger C2HC domain-containing protein 1C", "refseq_ac": [ { "id": "NP_001014101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014101", "type": "external" } ], "gene_names_uniprotkb": "Zc2hc1c; Fam164c", "gene_names_refseq": "Fam164c; RGD1307122; Zc2hc1c", "protein_names_uniprotkb": "Zinc finger C2HC domain-containing protein 1C", "protein_names_refseq": "family with sequence similarity 164, member C; protein FAM164C; zinc finger C2HC domain-containing protein 1C", "tax_id": 10116, "disease": "", "pathway": " (rno:314321)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYP4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYR4-1", "uniprot_id": [ { "id": "TOR2A_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYR4", "type": "external" } ], "mass": 35871.0, "length": 321, "protein_name": "Torsin-2A", "gene_name": "Tor2a", "organism": "Rat", "refseq_name": "torsin-2A precursor", "refseq_ac": [ { "id": "NP_001007745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007745", "type": "external" } ], "gene_names_uniprotkb": "Tor2a", "gene_names_refseq": "Tor2a", "protein_names_uniprotkb": "Torsin-2A; Torsin family 2 member A", "protein_names_refseq": "prosalusin; torsin-2A precursor; torsin-2A", "tax_id": 10116, "disease": "torsion dystonia 1 (Disease Ontology:DOID:0060730); dystonia (Disease Ontology:DOID:543)", "pathway": " (rno:362112)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18047553;18344632;23400761;26952533;28230187;30552345;33300078;37183727", "class_list": "", "function": "Antiinflammatory effect of salusinbeta knockdown on LPSactivated alveolar macrophages via NFkappaB inhibition and HO1 activation., [RefSeq, PubMed]; Here, the authors show that the beta-chain of ATP synthase is a cell surface receptor for salusin-beta Publication Status: Online-Only, [RefSeq, PubMed]; Rat salusin is immunologically similar to human salusin-beta and widely expressed, especially in the immune, gastrointestinal, and central nervous systems and mainly in endocrine- and hematopoietic-derived cells, [RefSeq, PubMed]; Salusin may be a endocrine and/or paracrine factor able to increase intracellular calcium concentrations and induce cell mitogenesis. Salusin may also be a potent hypotensive peptide (By similarity)., [UniProtKB]; Salusin-beta in the paraventricular nucleus increases blood pressure, heart rate, and sympathetic outflow via both circulating AVP and AVP in the rostral ventrolateral medulla in hypertensive rats., [RefSeq, PubMed]; Salusin-beta may be important in the vascular smooth muscle cell migration and neointima of some vascular diseases., [RefSeq, PubMed]; Salusin-beta may be involved in the regulation of body fluid balance by stimulating neurohypophyseal hormone release from nerve endings by an autocrine/paracrine mechanism., [RefSeq, PubMed]; These results indicate that silencing salusin-beta attenuates hypertension and cardiovascular remodeling in spontaneously hypertensive rats. Publication Status: Online-Only, [RefSeq, PubMed]; Upregulated expression of a TOR2A gene product-salusin-beta in the paraventricular nucleus enhances sympathetic activity and cardiac sympathetic afferent reflex in rats with chronic heart failure induced by coronary artery ligation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005635 nuclear envelope;GO:0005788 endoplasmic reticulum lumen;GO:0005737 cytoplasm;GO:0012505 endomembrane system", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0030103 vasopressin secretion;GO:1904427 positive regulation of calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6AYR4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYR6-1", "uniprot_id": [ { "id": "HDHD2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYR6", "type": "external" } ], "mass": 28779.0, "length": 259, "protein_name": "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "gene_name": "Hdhd2", "organism": "Rat", "refseq_name": "haloacid dehalogenase-like hydrolase domain-containing protein 2", "refseq_ac": [ { "id": "NP_001399426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001399426", "type": "external" } ], "gene_names_uniprotkb": "Hdhd2", "gene_names_refseq": "Hdhd2; Ier3ip1; LRRG00122; RGD1308579", "protein_names_uniprotkb": "Haloacid dehalogenase-like hydrolase domain-containing protein 2", "protein_names_refseq": "haloacid dehalogenase-like hydrolase domain-containing protein 2; immediate early response 3-interacting protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361351)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26103128", "class_list": "", "function": "Hdhd2 appears to act from upstream in a pathway by regulating Tcof1/treacle possibly at the level of post-translation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYR6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYU1-1", "uniprot_id": [ { "id": "MO4L1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYU1", "type": "external" } ], "mass": 37201.0, "length": 323, "protein_name": "Mortality factor 4-like protein 1", "gene_name": "Morf4l1", "organism": "Rat", "refseq_name": "mortality factor 4-like protein 1 isoform 5", "refseq_ac": [ { "id": "NP_001011999", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011999", "type": "external" } ], "gene_names_uniprotkb": "Morf4l1", "gene_names_refseq": "Morf4l1", "protein_names_uniprotkb": "Mortality factor 4-like protein 1; MORF-related gene 15 protein; Transcription factor-like protein MRG15", "protein_names_refseq": "MORF-related gene 15 protein; mortality factor 4-like protein 1 isoform 5; mortality factor 4-like protein 1; transcription factor-like protein MRG15", "tax_id": 10116, "disease": "", "pathway": " (rno:300891)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2. SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0035267 NuA4 histone acetyltransferase complex;GO:0070822 Sin3-type complex;GO:0000786 nucleosome;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008283 cell population proliferation;GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYU1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6BBI8-1", "uniprot_id": [ { "id": "UFC1_RAT", "url": "https://www.uniprot.org/uniprot/Q6BBI8", "type": "external" } ], "mass": 19492.0, "length": 167, "protein_name": "Ubiquitin-fold modifier-conjugating enzyme 1", "gene_name": "Ufc1", "organism": "Rat", "refseq_name": "ubiquitin-fold modifier-conjugating enzyme 1 isoform 1", "refseq_ac": [ { "id": "NP_001003709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003709", "type": "external" } ], "gene_names_uniprotkb": "Ufc1", "gene_names_refseq": "Ufc1; ufc1-s", "protein_names_uniprotkb": "Ubiquitin-fold modifier-conjugating enzyme 1; Ufm1-conjugating enzyme 1", "protein_names_refseq": "Ufm1-conjugating enzyme 1-; ubiquitin-fold modifier-conjugating enzyme 1 isoform 1; ufm1-conjugating enzyme 1", "tax_id": 10116, "disease": "neurodevelopmental disorder with spasticity and poor growth (Disease Ontology:DOID:0070421)", "pathway": " (rno:445268)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E2-like enzyme which specifically catalyzes the second step in ufmylation. Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage. Ufmylation is involved in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071568 UFM1 transferase activity;GO:0061657 UFM1 conjugating enzyme activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007420 brain development;GO:0034976 response to endoplasmic reticulum stress;GO:0071569 protein ufmylation;GO:0061709 reticulophagy;GO:1990592 protein K69-linked ufmylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6BBI8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DG50-1", "uniprot_id": [ { "id": "TBKB1_RAT", "url": "https://www.uniprot.org/uniprot/Q6DG50", "type": "external" } ], "mass": 67155.0, "length": 613, "protein_name": "TANK-binding kinase 1-binding protein 1", "gene_name": "Tbkbp1", "organism": "Rat", "refseq_name": "TANK-binding kinase 1-binding protein 1", "refseq_ac": [ { "id": "NP_742018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742018", "type": "external" } ], "gene_names_uniprotkb": "Tbkbp1", "gene_names_refseq": "Prosapip2; Tbkbp1", "protein_names_uniprotkb": "TANK-binding kinase 1-binding protein 1; Protein ProSAPiP2; TBK1-binding protein 1", "protein_names_refseq": "TANK-binding kinase 1-binding protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:266764)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19481056", "class_list": "", "function": "A novel interaction partner of ProSAP2/Shank3, named ProSAP interacting protein 2 (ProSAPiP2) that does not show any close homology to other known proteins, was characterized, [RefSeq, PubMed]; Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1Q5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DG50-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6E0V2-1", "uniprot_id": [ { "id": "KTNA1_RAT", "url": "https://www.uniprot.org/uniprot/Q6E0V2", "type": "external" } ], "mass": 55844.0, "length": 491, "protein_name": "Katanin p60 ATPase-containing subunit A1", "gene_name": "Katna1", "organism": "Rat", "refseq_name": "katanin p60 ATPase-containing subunit A1", "refseq_ac": [ { "id": "NP_001004217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004217", "type": "external" } ], "gene_names_uniprotkb": "Katna1; KATNA1", "gene_names_refseq": "Katna1", "protein_names_uniprotkb": "Katanin p60 ATPase-containing subunit A1; 5.6.1.1; Katanin p60 subunit A1; p60 katanin", "protein_names_refseq": "katanin p60 ATPase-containing subunit A1; katanin p60 subunit A 1; katanin p60 subunit A1; microtubule severing protein; p60 katanin", "tax_id": 10116, "disease": "", "pathway": " (rno:292464)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10209026;15215300;15944385;24303010;29393594;31963385;34260930", "class_list": "", "function": "Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth., [UniProtKB, HAMAP, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Katanin p60 contributes to microtubule instability around the midbody and facilitates cytokinesis in rat cells. Publication Status: Online-Only, [RefSeq, PubMed]; RhoA-GTPase Modulates Neurite Outgrowth by Regulating the Expression of Spastin and p60-Katanin. Publication Status: Online-Only, [RefSeq, PubMed]; The ratio of P60 to P80 varies markedly in different tissues, at different phases of development, and regionally within the neuron. Suggested that the effects on neuronal morphology are dependent on the degree of microtubule severing and loss of polymer, [RefSeq, PubMed]; WDR47 protects neuronal microtubule minus ends from katanin-mediated severing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V7G3", "ec_number_list": [], "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0046982 protein heterodimerization activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0008352 katanin complex;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet", "go_biological_process": "GO:0051013 microtubule severing;GO:0051301 cell division;GO:0001764 neuron migration;GO:0010977 negative regulation of neuron projection development;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6E0V2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6I7R5-1", "uniprot_id": [ { "id": "TCAL8_RAT", "url": "https://www.uniprot.org/uniprot/Q6I7R5", "type": "external" } ], "mass": 13447.0, "length": 117, "protein_name": "Transcription elongation factor A protein-like 8", "gene_name": "Tceal8", "organism": "Rat", "refseq_name": "transcription elongation factor A protein-like 8", "refseq_ac": [ { "id": "NP_001014297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014297", "type": "external" } ], "gene_names_uniprotkb": "Tceal8; UR-NR#1", "gene_names_refseq": "Tceal8; UR-NR#1", "protein_names_uniprotkb": "Transcription elongation factor A protein-like 8; TCEA-like protein 8; Transcription elongation factor S-II protein-like 8; Up-regulated in nephrectomized rat kidney #1", "protein_names_refseq": "TCEA-like protein 8; transcription elongation factor A (SII)-like 8; transcription elongation factor A protein-like 8; transcription elongation factor S-II protein-like 8; up-regulated in nephrectomized rat kidney #1", "tax_id": 10116, "disease": "", "pathway": " (rno:367909)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15200410;29393594", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6I7R5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IE46-1", "uniprot_id": [ { "id": "ISK14_RAT", "url": "https://www.uniprot.org/uniprot/Q6IE46", "type": "external" } ], "mass": 11237.0, "length": 98, "protein_name": "Serine protease inhibitor Kazal-type 14", "gene_name": "Spink14", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Spink14; Spink5l2", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 14", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15060002", "class_list": "", "function": "May be a serine protease inhibitor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045861 negative regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IE46-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IE49-1", "uniprot_id": [ { "id": "ISK2_RAT", "url": "https://www.uniprot.org/uniprot/Q6IE49", "type": "external" } ], "mass": 9697.0, "length": 86, "protein_name": "Serine protease inhibitor Kazal-type 2", "gene_name": "Spink2", "organism": "Rat", "refseq_name": "serine protease inhibitor Kazal-type 2 precursor", "refseq_ac": [ { "id": "NP_001008870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008870", "type": "external" } ], "gene_names_uniprotkb": "Spink2", "gene_names_refseq": "Spink2", "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 2", "protein_names_refseq": "Kazal type serine protease inhibitor 2; serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor); serine protease inhibitor Kazal-type 2 precursor; serine protease inhibitor Kazal-type 2-like; serine protease inhibitor Kazal-type 2; serine protease inhibitor Kazal-type2", "tax_id": 10116, "disease": "spermatogenic failure 29 (Disease Ontology:DOID:0111930)", "pathway": " (rno:408234)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15060002;36462395", "class_list": "", "function": "As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects. May be involved in the regulation of serine protease-dependent germ cell apoptosis. It also inhibits trypsin., [UniProtKB, UniProtKB]; Characterization of SPINK2, SPACA7 and PDCL2: Effect of immunization on fecundity, sperm function and testicular transcriptome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0001669 acrosomal vesicle;GO:0043005 neuron projection", "go_biological_process": "GO:0007283 spermatogenesis;GO:0009566 fertilization;GO:0043065 positive regulation of apoptotic process;GO:0007286 spermatid development;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6IE49-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IE52-1", "uniprot_id": [ { "id": "MUG2_RAT", "url": "https://www.uniprot.org/uniprot/Q6IE52", "type": "external" } ], "mass": 161589.0, "length": 1448, "protein_name": "Murinoglobulin-2", "gene_name": "Mug2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mug2", "gene_names_refseq": "", "protein_names_uniprotkb": "Murinoglobulin-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15060002", "class_list": "", "function": "A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective., [UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IE52-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG22-1", "uniprot_id": [ { "id": "MUCL3_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG22", "type": "external" } ], "mass": 51393.0, "length": 470, "protein_name": "Mucin-like protein 3", "gene_name": "Mucl3", "organism": "Rat", "refseq_name": "mucin-like protein 3 precursor", "refseq_ac": [ { "id": "NP_001003965", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003965", "type": "external" } ], "gene_names_uniprotkb": "Mucl3; Dpcr1", "gene_names_refseq": "Dpcr1; Mucl3", "protein_names_uniprotkb": "Mucin-like protein 3; Diffuse panbronchiolitis critical region protein 1 homolog", "protein_names_refseq": "diffuse panbronchiolitis critical region 1; diffuse panbronchiolitis critical region protein 1 homolog; mucin-like protein 3 precursor; mucin-like protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:406199)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15060004", "class_list": "", "function": "May modulate NF-kappaB signaling and play a role in cell growth., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6MG22-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG53-1", "uniprot_id": [ { "id": "LY65B_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG53", "type": "external" } ], "mass": 21588.0, "length": 194, "protein_name": "Lymphocyte antigen 6 complex locus protein G5b", "gene_name": "Ly6g5b", "organism": "Rat", "refseq_name": "lymphocyte antigen 6 complex locus protein G5b precursor", "refseq_ac": [ { "id": "NP_001001934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001934", "type": "external" } ], "gene_names_uniprotkb": "Ly6g5b", "gene_names_refseq": "Ly6g5b", "protein_names_uniprotkb": "Lymphocyte antigen 6 complex locus protein G5b", "protein_names_refseq": "lymphocyte antigen 6 complex G5B; lymphocyte antigen 6 complex locus protein G5b precursor; lymphocyte antigen 6 complex locus protein G5b; lymphocyte antigen 6 complex, locus G5B", "tax_id": 10116, "disease": "", "pathway": " (rno:406867)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15060004", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009897 external side of plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6MG53-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P502-1", "uniprot_id": [ { "id": "TCPG_RAT", "url": "https://www.uniprot.org/uniprot/Q6P502", "type": "external" } ], "mass": 60647.0, "length": 545, "protein_name": "T-complex protein 1 subunit gamma", "gene_name": "Cct3", "organism": "Rat", "refseq_name": "T-complex protein 1 subunit gamma", "refseq_ac": [ { "id": "NP_954522", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954522", "type": "external" } ], "gene_names_uniprotkb": "Cct3", "gene_names_refseq": "Cct3", "protein_names_uniprotkb": "T-complex protein 1 subunit gamma; 3.6.1.-; CCT-gamma; TCP-1-gamma", "protein_names_refseq": "CCT-gamma; T-complex protein 1 subunit gamma; TCP-1-gamma; chaperonin containing Tcp1, subunit 3 (gamma); chaperonin subunit 3 (gamma)", "tax_id": 10116, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (rno:295230); (R-RNO-390471); (R-RNO-5620922); (R-RNO-6814122)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "22673903;29393594;38843836", "class_list": "", "function": "Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005874 microtubule;GO:0044297 cell body;GO:0005832 chaperonin-containing T-complex;GO:0002199 zona pellucida receptor complex", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0050821 protein stabilization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6P502-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6S4-1", "uniprot_id": [ { "id": "SIL1_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6S4", "type": "external" } ], "mass": 52350.0, "length": 465, "protein_name": "Nucleotide exchange factor SIL1", "gene_name": "Sil1", "organism": "Rat", "refseq_name": "nucleotide exchange factor SIL1 precursor", "refseq_ac": [ { "id": "NP_955408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955408", "type": "external" } ], "gene_names_uniprotkb": "Sil1", "gene_names_refseq": "Sil1", "protein_names_uniprotkb": "Nucleotide exchange factor SIL1", "protein_names_refseq": "SIL1 homolog, endoplasmic reticulum chaperone; nucleotide exchange factor SIL1 precursor; nucleotide exchange factor SIL1", "tax_id": 10116, "disease": "Marinesco-Sjogren syndrome (Disease Ontology:DOID:0080195); primary cerebellar degeneration (Disease Ontology:DOID:9277)", "pathway": " (rno:291673)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P6S4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P7C4-1", "uniprot_id": [ { "id": "LRC26_RAT", "url": "https://www.uniprot.org/uniprot/Q6P7C4", "type": "external" } ], "mass": 36073.0, "length": 334, "protein_name": "Leucine-rich repeat-containing protein 26", "gene_name": "Lrrc26", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 26 precursor", "refseq_ac": [ { "id": "NP_001014075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014075", "type": "external" } ], "gene_names_uniprotkb": "Lrrc26", "gene_names_refseq": "Lrrc26; RGD1308398", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 26; BK channel auxiliary gamma subunit LRRC26", "protein_names_refseq": "BK channel auxiliary gamma subunit LRRC26; BK channel auxilliary gamma subunit LRRC26; leucine-rich repeat-containing protein 26 precursor; leucine-rich repeat-containing protein 26", "tax_id": 10116, "disease": "", "pathway": " (rno:311803)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24906643", "class_list": "", "function": "Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium (By similarity)., [UniProtKB]; Study indicates that arterial myocytes express LRRC26 which functions as BK channel gamma subunit., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0005249 voltage-gated potassium channel activity;GO:0099104 potassium channel activator activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1903818 positive regulation of voltage-gated potassium channel activity;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P7C4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDU1-1", "uniprot_id": [ { "id": "SRSF2_RAT", "url": "https://www.uniprot.org/uniprot/Q6PDU1", "type": "external" } ], "mass": 25476.0, "length": 221, "protein_name": "Serine/arginine-rich splicing factor 2", "gene_name": "Srsf2", "organism": "Rat", "refseq_name": "serine/arginine-rich splicing factor 2", "refseq_ac": [ { "id": "NP_001009720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009720", "type": "external" } ], "gene_names_uniprotkb": "Srsf2; Sfrs2", "gene_names_refseq": "Sfrs2; Srsf2", "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 2; SC-35; Splicing component, 35 kDa; Splicing factor SC35; Splicing factor, arginine/serine-rich 2", "protein_names_refseq": "SC-35; serine/arginine-rich splicing factor 2; splicing component, 35 kDa; splicing factor SC35; splicing factor, arginine/serine-rich 2", "tax_id": 10116, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); pulmonary neuroendocrine tumor (Disease Ontology:DOID:5410); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:494445); (R-RNO-159236); (R-RNO-72163); (R-RNO-72165); (R-RNO-72203); (R-RNO-9770562)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "11683997;22673903", "class_list": "", "function": "Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003729 mRNA binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005726 perichromatin fibrils;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0033197 response to vitamin E;GO:0008380 RNA splicing;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PDU1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QI89-1", "uniprot_id": [ { "id": "MO4L2_RAT", "url": "https://www.uniprot.org/uniprot/Q6QI89", "type": "external" } ], "mass": 32214.0, "length": 288, "protein_name": "Mortality factor 4-like protein 2", "gene_name": "Morf4l2", "organism": "Rat", "refseq_name": "mortality factor 4-like protein 2", "refseq_ac": [ { "id": "NP_001007715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007715", "type": "external" } ], "gene_names_uniprotkb": "Morf4l2", "gene_names_refseq": "LRRG00119; Morf4l2", "protein_names_uniprotkb": "Mortality factor 4-like protein 2; Liver regeneration-related protein LRRG00119; MORF-related gene X protein; Transcription factor-like protein MRGX", "protein_names_refseq": "MORF-related gene X protein; liver regeneration-related protein LRRG00119; mortality factor 4-like protein 2; transcription factor-like protein MRGX", "tax_id": 10116, "disease": "", "pathway": " (rno:317413)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000786 nucleosome", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6QI89-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QMY6-1", "uniprot_id": [ { "id": "TSK_RAT", "url": "https://www.uniprot.org/uniprot/Q6QMY6", "type": "external" } ], "mass": 38091.0, "length": 353, "protein_name": "Tsukushi", "gene_name": "Tsku", "organism": "Rat", "refseq_name": "tsukushi precursor", "refseq_ac": [ { "id": "NP_001009965", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009965", "type": "external" } ], "gene_names_uniprotkb": "Tsku; Eiih; Lrrc54; Tsk", "gene_names_refseq": "Eiih; Tsku", "protein_names_uniprotkb": "Tsukushi; EIIH; Early insulin-induced hepatic gene protein; Leucine-rich repeat-containing protein 54", "protein_names_refseq": "early insulin-induced hepatic gene protein; hepatic protein EIIH; leucine-rich repeat-containing protein 54; tsukushi precursor; tsukushin", "tax_id": 10116, "disease": "", "pathway": " (rno:308843)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15344907;22880013", "class_list": "", "function": "Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways. Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye. Plays a role in regulating the hair cycle by controlling TGFB1 signaling. Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth. Essential for terminal differentiation of hippocampal neural stem cells. Plays a role in regulating bone elongation and bone mass by modulating growth plate chondrocyte function and overall body size. Required for development of the inner ear through its involvement in stereocilia formation in inner hair cells. Facilitates wound healing by inhibiting secretion of TGFB1 from macrophages which prevents myofibroblast differentiation, maintaining inflammatory cell quiescence. Plays a role in cholesterol homeostasis by reducing circulating high-density lipoprotein cholesterol, lowering cholesterol efflux capacity and decreasing cholesterol-to-bile acid conversion in the liver. In one study, shown to negatively regulate sympathetic innervation in brown fat, leading to reduced energy expenditure. In another study, shown not to affect brown fat thermogenic capacity, body weight gain or glucose homeostasis., [UniProtKB, UniProtKB]; The spatio-temporal expression of Decorin, Semaphorin6D, SPARC, Spry-1 and Tsukushi in developing prostate is described and observed similar mesenchymal expression patterns in rat and human., [RefSeq, PubMed]; Tissue distribution of EIIH in adult rats revealed a pattern of expression mainly in the liver, intestine and islets of Langerhans, closely following that of the Glut2 (glucose transporter 2), suggesting that it may play a role in carbohydrate metabolism, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050431 transforming growth factor beta binding;GO:0038023 signaling receptor activity;GO:0019955 cytokine binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005576 extracellular region", "go_biological_process": "GO:1904761 negative regulation of myofibroblast differentiation;GO:0008203 cholesterol metabolic process;GO:0021766 hippocampus development;GO:0097009 energy homeostasis;GO:0010977 negative regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6QMY6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TA48-1", "uniprot_id": [ { "id": "MPTX_RAT", "url": "https://www.uniprot.org/uniprot/Q6TA48", "type": "external" } ], "mass": 24332.0, "length": 219, "protein_name": "Mucosal pentraxin", "gene_name": "Mptx1", "organism": "Rat", "refseq_name": "mucosal pentraxin precursor", "refseq_ac": [ { "id": "NP_001032731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032731", "type": "external" } ], "gene_names_uniprotkb": "Mptx1; Mptx", "gene_names_refseq": "Mptx1; Mptx", "protein_names_uniprotkb": "Mucosal pentraxin", "protein_names_refseq": "mucosal pentraxin precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:289243)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12832292;15539406;16978845;18850182", "class_list": "", "function": "Mptx expression is restricted to the intestine, related to colonic cell turnover, and that Mptx might be a marker for diet-modulated mucosal integrity, [RefSeq, PubMed]; Mucosal pentraxin (Mptx) is down-regulated in colon by dietary heme (Mptx)., [RefSeq, PubMed]; This study demonstrates that consideration of regional differences in Mptx gene expression and micro-anatomical location is necessary in the interpretation and deciphering of its regulation in colon., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0001849 complement component C1q complex binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0006953 acute-phase response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6TA48-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TEK3-1", "uniprot_id": [ { "id": "VKORL_RAT", "url": "https://www.uniprot.org/uniprot/Q6TEK3", "type": "external" } ], "mass": 19779.0, "length": 176, "protein_name": "Vitamin K epoxide reductase complex subunit 1-like protein 1", "gene_name": "Vkorc1l1", "organism": "Rat", "refseq_name": "vitamin K epoxide reductase complex subunit 1-like protein 1", "refseq_ac": [ { "id": "NP_976083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_976083", "type": "external" } ], "gene_names_uniprotkb": "Vkorc1l1", "gene_names_refseq": "Vkorc1l1", "protein_names_uniprotkb": "Vitamin K epoxide reductase complex subunit 1-like protein 1; 1.17.4.4; VKORC1-like protein 1", "protein_names_refseq": "VKORC1-like protein 1; vitamin K epoxide reductase complex subunit 1-like protein 1; vitamin K epoxide reductase complex, subunit 1-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:399684); (R-RNO-6806664)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14765194;23928358", "class_list": "", "function": "Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K, and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins., [UniProtKB, PubMed]; Molecular cloning, [RefSeq, PubMed]; The involvement of VKORC1L1 in VKOR activity partly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.17.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.17.4.4", "type": "external" } ], "go_molecular_function": "GO:0047057 vitamin-K-epoxide reductase (warfarin-sensitive) activity;GO:0048038 quinone binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0017187 peptidyl-glutamic acid carboxylation;GO:0042373 vitamin K metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6TEK3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TUF2-1", "uniprot_id": [ { "id": "SDHF3_RAT", "url": "https://www.uniprot.org/uniprot/Q6TUF2", "type": "external" } ], "mass": 14525.0, "length": 125, "protein_name": "Succinate dehydrogenase assembly factor 3, mitochondrial", "gene_name": "Sdhaf3", "organism": "Rat", "refseq_name": "succinate dehydrogenase assembly factor 3, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001399494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001399494", "type": "external" } ], "gene_names_uniprotkb": "Sdhaf3; Acn9", "gene_names_refseq": "Acn9; LRRGT00092; Sdhaf3", "protein_names_uniprotkb": "Succinate dehydrogenase assembly factor 3, mitochondrial; Liver regeneration-related protein LRRGT00092; SDH assembly factor 3; SDHAF3", "protein_names_refseq": "SDH assembly factor 3; liver regeneration-related protein LRRGT00092; protein ACN9 homolog, mitochondrial; succinate dehydrogenase assembly factor 3, mitochondrial precursor; succinate dehydrogenase assembly factor 3, mitochondrial", "tax_id": 10116, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); paraganglioma (Disease Ontology:DOID:0050773); mitochondrial complex II deficiency (Disease Ontology:DOID:0060537)", "pathway": " (rno:362323); (R-RNO-9854311)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit Sdhb of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0034553 mitochondrial respiratory chain complex II assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6TUF2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6X9T7-1", "uniprot_id": [ { "id": "TYOBP_RAT", "url": "https://www.uniprot.org/uniprot/Q6X9T7", "type": "external" } ], "mass": 12361.0, "length": 114, "protein_name": "TYRO protein tyrosine kinase-binding protein", "gene_name": "Tyrobp", "organism": "Rat", "refseq_name": "TYRO protein tyrosine kinase-binding protein precursor", "refseq_ac": [ { "id": "NP_997690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997690", "type": "external" } ], "gene_names_uniprotkb": "Tyrobp; Dap12", "gene_names_refseq": "Karap; Tyrobp", "protein_names_uniprotkb": "TYRO protein tyrosine kinase-binding protein; DNAX-activation protein 12", "protein_names_refseq": "DAP12; DNAX-activation protein 12; TYRO protein tyrosine kinase-binding protein precursor; TYRO protein tyrosine kinase-binding protein; Tyro protein tyrosine kinase binding protein; killer cell activating receptor-associated protein", "tax_id": 10116, "disease": "Nasu-Hakola disease (Disease Ontology:DOID:0090112); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (rno:361537); (R-RNO-2172127); (R-RNO-2424491); (R-RNO-391160); (R-RNO-416700); (R-RNO-6798695)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "38639190", "class_list": "", "function": "Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors of the CD300 family to mediate cell activation (By similarity). Also mediates cell activation through association with activating receptors of the CD200R family (By similarity). Required for neutrophil activation mediated by integrin (By similarity). Required for the activation of myeloid cells mediated by the CLEC5A/MDL1 receptor (By similarity). Associates with natural killer (NK) cell receptors such as the KLRD1/KLRC2 heterodimer to mediate NK cell activation (By similarity). Associates with TREM1 to mediate activation of neutrophils and monocytes (By similarity). Associates with TREM2 on monocyte-derived dendritic cells to mediate up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (By similarity). PAssociation with TREM2 mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity). Stabilizes the TREM2 C-terminal fragment (TREM2-CTF) produced by TREM2 ectodomain shedding which suppresses the release of pro-inflammatory cytokines (By similarity). In microglia, required with TREM2 for phagocytosis of apoptotic neurons (By similarity). Required with ITGAM/CD11B in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). Promotes pro-inflammatory responses in microglia following nerve injury which accelerates degeneration of injured neurons (By similarity). ositively regulates the expression of the IRAK3/IRAK-M kinase and IL10 production by liver dendritic cells and inhibits their T cell allosimulatory ability (By similarity). Negatively regulates B cell proliferation (By similarity). Required for CSF1-mediated osteoclast cytoskeletal organization (By similarity). Positively regulates multinucleation during osteoclast development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Deciphering microglial activation and neuronal apoptosis post-traumatic brain injury: The role of TYROBP in inflammation regulation networks., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005102 signaling receptor binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:2001206 positive regulation of osteoclast development;GO:0032693 negative regulation of interleukin-10 production;GO:0002228 natural killer cell mediated immunity;GO:0002283 neutrophil activation involved in immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6X9T7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6XFR6-1", "uniprot_id": [ { "id": "GLPC_RAT", "url": "https://www.uniprot.org/uniprot/Q6XFR6", "type": "external" } ], "mass": 10443.0, "length": 95, "protein_name": "Glycophorin-C", "gene_name": "Gypc", "organism": "Rat", "refseq_name": "glycophorin-C", "refseq_ac": [ { "id": "NP_001013251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013251", "type": "external" } ], "gene_names_uniprotkb": "Gypc", "gene_names_refseq": "GPC; Gypc", "protein_names_uniprotkb": "Glycophorin-C", "protein_names_refseq": "glycophorin C (Gerbich blood group); glycophorin-C", "tax_id": 10116, "disease": "malaria (Disease Ontology:DOID:12365)", "pathway": " (rno:364837)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030863 cortical cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6XFR6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q700K0-1", "uniprot_id": [ { "id": "SSPO_RAT", "url": "https://www.uniprot.org/uniprot/Q700K0", "type": "external" } ], "mass": 550649.0, "length": 5141, "protein_name": "SCO-spondin", "gene_name": "Sspo", "organism": "Rat", "refseq_name": "SCO-spondin precursor", "refseq_ac": [ { "id": "NP_001007017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007017", "type": "external" } ], "gene_names_uniprotkb": "Sspo", "gene_names_refseq": "Scospondin; Sspo", "protein_names_uniprotkb": "SCO-spondin", "protein_names_refseq": "SCO-spondin precursor; subcommissural organ spondin", "tax_id": 10116, "disease": "scoliosis (Disease Ontology:DOID:0060249); idiopathic scoliosis (Disease Ontology:DOID:0060250)", "pathway": " (rno:474348); (R-RNO-5173214)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15469891", "class_list": "", "function": "Involved in the modulation of neuronal aggregation (By similarity). May be involved in developmental events during the formation of the central nervous system (By similarity)., [UniProtKB, UniProtKB]; Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system., [UniProtKB, UniProtKB]; Results indicate that 5HT down-regulates SCO-spondin biosynthesis but apparently not its release, and suggest that 5HT may exert the effect on the SCO via the cerebrospinal fluid., [RefSeq, PubMed]", "predicted_glycosites": 46, "predicted_n_glycosites": 43, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 46, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q700K0-1", "record_type": "protein", "filter_code": "0000000.1000111.000100.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q701R3-1", "uniprot_id": [ { "id": "SIAT2_RAT", "url": "https://www.uniprot.org/uniprot/Q701R3", "type": "external" } ], "mass": 59917.0, "length": 525, "protein_name": "Beta-galactoside alpha-2,6-sialyltransferase 2", "gene_name": "St6gal2", "organism": "Rat", "refseq_name": "beta-galactoside alpha-2,6-sialyltransferase 2", "refseq_ac": [ { "id": "NP_001094358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094358", "type": "external" } ], "gene_names_uniprotkb": "St6gal2", "gene_names_refseq": "ST6Gal-II; ST6GalII; St6gal2", "protein_names_uniprotkb": "Beta-galactoside alpha-2,6-sialyltransferase 2; 2.4.3.1; Alpha 2,6-ST 2; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2; ST6Gal II; ST6GalII; Sialyltransferase 2", "protein_names_refseq": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 6-sialyltransferase 2; ST6 beta-galactosamide alpha-2,6-sialyltranferase 2; ST6Gal II; alpha 2,6-ST 2; beta-galactoside alpha-2,6-sialyltransferase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:301155); (R-RNO-4085001)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15843597", "class_list": "glycogene;glycosyltransferase", "function": "Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.1", "type": "external" } ], "go_molecular_function": "GO:0008373 sialyltransferase activity;GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0009311 oligosaccharide metabolic process;GO:0097503 sialylation", "synthesized_glycan_count": 1722, "hit_score": 0.2, "record_id": "Q701R3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q71F54-1", "uniprot_id": [ { "id": "SH3R1_RAT", "url": "https://www.uniprot.org/uniprot/Q71F54", "type": "external" } ], "mass": 93879.0, "length": 894, "protein_name": "E3 ubiquitin-protein ligase SH3RF1", "gene_name": "Sh3rf1", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase SH3RF1", "refseq_ac": [ { "id": "NP_942059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942059", "type": "external" } ], "gene_names_uniprotkb": "Sh3rf1; Posh1; Posh; Sh3md2", "gene_names_refseq": "Posh; Sh3md2; Sh3rf1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase SH3RF1; 2.3.2.27; Plenty of SH3s; Protein POSH; RING-type E3 ubiquitin transferase SH3RF1; SH3 domain-containing RING finger protein 1; SH3 multiple domains protein 2", "protein_names_refseq": "E3 ubiquitin-protein ligase SH3RF1; RING-type E3 ubiquitin transferase SH3RF1; SH3 domain-containing RING finger protein 1; SH3 multiple domains protein 2; plenty of SH3s; putative E3 ubiquitin-protein ligase SH3RF1; putative scaffolding protein POSH", "tax_id": 10116, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:306417); (R-RNO-9013424); (R-RNO-983168)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "12514131;16230351;16248889;16571722;17095503;19710010;22128169;22673903", "class_list": "", "function": "A model in which Sh3rf2 promotes proteasomal degradation of pro-apoptotic POSH in healthy cells and in which apoptotic stimuli lead to rapid loss of Sh3rf2 expression, and consequently to stabilization of POSH and JNK activation and cell death, [RefSeq, PubMed]; Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing its dynamin-dependent and clathrin-independent endocytosis (By similarity). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway (PubMed:12514131). Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Nix promotes cell death via interaction with POSH and activation of the JNK/c-Jun pathway and that Nix protein is induced and contributes to cell death in a cellular model of Parkinson disease, [RefSeq, PubMed]; POSH inhibits ROMK channels by enhancing dynamin-dependent and clathrin-independent endocytosis and by stimulating ubiquitination of ROMK channels., [RefSeq, PubMed]; POSH might serve as a scaffold mediating JNK signalling activation in the hippocampal CA1 region following cerebral ischaemia, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0005078 MAP-kinase scaffold activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:2000564 regulation of CD8-positive, alpha-beta T cell proliferation;GO:0043066 negative regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0001764 neuron migration;GO:2001237 negative regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q71F54-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true } ]